• 1719 Citations
  • 23 h-Index
20002020

Research output per year

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Research Output

  • 1719 Citations
  • 23 h-Index
  • 41 Article
  • 1 Comment/debate
  • 1 Review article
2020

The role of the bacterial protease Prc in the uropathogenesis of extraintestinal pathogenic Escherichia coli

Huang, W. C., Lin, C. Y., Hashimoto, M., Wu, J. J., Wang, M. C., Lin, W. H., Chen, C. S. & Teng, C. H., 2020 Jan 3, In : Journal of biomedical science. 27, 1, 1 p.

Research output: Contribution to journalArticle

Open Access
2018

A multi-omic analysis reveals the role of fumarate in regulating the virulence of enterohemorrhagic Escherichia coli

Kuo, C. J., Wang, S. T., Lin, C. M., Chiu, H. C., Huang, C. R., Lee, D. Y., Chang, G. D., Chou, T. C., Chen, J. W. & Chen, C. S., 2018 Mar 1, In : Cell Death and Disease. 9, 3, 381.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Design and synthesis of malonamide derivatives as antibiotics against methicillin-resistant staphylococcus aureus

Su, J. C., Huang, Y. T., Chen, C. S., Chiu, H. C. & Shiau, C. W., 2018 Jan 1, In : Molecules. 23, 1, 27.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Evaluating virulence and pathogenesis of Aeromonas Infection in a Caenorhabditis elegans model

Chen, Y. W., Ko, W. C., Chen, C. S. & Chen, P. L., 2018 Dec, In : Journal of Visualized Experiments. 2018, 142, e58768.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Rationally designed divalent caffeic amides inhibit amyloid-β fibrillization, induce fibril dissociation, and ameliorate cytotoxicity

Tu, L. H., Tseng, N. H., Tsai, Y. R., Lin, T. W., Lo, Y. W., Charng, J. L., Hsu, H. T., Chen, Y. S., Chen, R. J., Wu, Y. T., Chan, Y. T., Chen, C. S., Fang, J. M. & Chen, Y. R., 2018 Oct 5, In : European Journal of Medicinal Chemistry. 158, p. 393-404 12 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

RIOK-1 is a suppressor of the p38 MAPK innate immune pathway in Caenorhabditis elegans

Chen, Y. W., Ko, W. C., Chen, C. S. & Chen, P. L., 2018 Apr 17, In : Frontiers in Immunology. 9, APR, 774.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2017

A disease model of muscle necrosis caused by aeromonas dhakensis infection in caenorhabditis elegans

Chen, P. L., Chen, Y. W., Ou, C. C., Lee, T. M., Wu, C. J., Ko, W. C. & Chen, C. S., 2017 Jan 4, In : Frontiers in Microbiology. 7, JAN, 2058.

Research output: Contribution to journalArticle

7 Citations (Scopus)

HLH-30/TFEB-mediated autophagy functions in a cell-autonomous manner for epithelium intrinsic cellular defense against bacterial pore-forming toxin in C. elegans

Chen, H. D., Kao, C. Y., Liu, B. Y., Huang, S. W., Kuo, C. J., Ruan, J. W., Lin, Y. H., Huang, C. R., Chen, Y. H., Wang, H. D., Aroian, R. V. & Chen, C. S., 2017 Feb 1, In : Autophagy. 13, 2, p. 371-385 15 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Neuroprotective Effects of Betulin in Pharmacological and Transgenic Caenorhabditis elegans Models of Parkinson’s Disease

Tsai, C. W., Tsai, R. T., Liu, S. P., Chen, C. S., Tsai, M. C., Chien, S. H., Hung, H. S., Lin, S. Z., Shyu, W. C. & Fu, R. H., 2017 Dec 1, In : Cell Transplantation. 26, 12, p. 1903-1918 16 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

TGFβ promotes mesenchymal phenotype of pancreatic cancer cells, in part, through epigenetic activation of VAV1

Huang, P. H., Lu, P. J., Ding, L. Y., Chu, P. C., Hsu, W. Y., Chen, C. S., Tsao, C. C., Chen, B. H., Lee, C. T., Shan, Y. S. & Chen, C. S., 2017 Apr 20, In : Oncogene. 36, 16, p. 2202-2214 13 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)
2016

Exercise in an electrotactic flow chamber ameliorates age-related degeneration in Caenorhabditis elegans

Chuang, H. S., Kuo, W. J., Lee, C. L., Chu, I. H. & Chen, C. S., 2016 Jun 16, In : Scientific reports. 6, 28064.

Research output: Contribution to journalArticle

19 Citations (Scopus)

In vitro and in vivo activity of a novel sorafenib derivative SC5005 against MRSA

Chang, H. C., Huang, Y. T., Chen, C. S., Chen, Y. W., Huang, Y. T., Su, J. C., Teng, L. J., Shiau, C. W. & Chiu, H. C., 2016 Feb 1, In : Journal of Antimicrobial Chemotherapy. 71, 2, p. 449-459 11 p., dkv367.

Research output: Contribution to journalArticle

4 Citations (Scopus)
6 Citations (Scopus)
2015
15 Citations (Scopus)

Loss of DNase II function in the gonad is associated with a higher expression of antimicrobial genes in Caenorhabditis elegans

Yu, H., Lai, H. J., Lin, T. W., Chen, C-S. & Lo, S. J., 2015 Aug 15, In : Biochemical Journal. 470, 1, p. 145-154 10 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
2014

Acetylcorynoline attenuates dopaminergic neuron degeneration and α-synuclein aggregation in animal models of Parkinson's disease

Fu, R. H., Wang, Y. C., Chen, C. S., Tsai, R. T., Liu, S. P., Chang, W. L., Lin, H. L., Lu, C. H., Wei, J. R., Wang, Z. W., Shyu, W. C. & Lin, S. Z., 2014 Jul, In : Neuropharmacology. 82, p. 108-120 13 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)
30 Citations (Scopus)

N-Butylidenephthalide protects against dopaminergic neuron degeneration and α-synuclein accumulation in Caenorhabditis elegans models of Parkinson's disease

Fu, R. H., Harn, H. J., Liu, S. P., Chen, C. S., Chang, W. L., Chen, Y. M., Huang, J. E., Li, R. J., Tsai, S. Y., Hung, H. S., Shyu, W. C., Lin, S. Z. & Wang, Y. C., 2014 Jan 8, In : PloS one. 9, 1, e85305.

Research output: Contribution to journalArticle

40 Citations (Scopus)

Virulence diversity among bacteremic aeromonas isolates: Ex Vivo, animal, and clinical evidences

Po-Lin, C., Chi-Jung, W., Pei-Jane, T., Hung-Jen, T., Yin-Ching, C., Nan-Yao, L., Ching-Chi, L., Chia-Wen, L., Ming-Chi, L., Chi-Chung, C. H. W. T., Chun-Chun, O., Chang-Shi, C. & Wen-Chien, K., 2014 Nov 6, In : PloS one. 9, 11, e111213.

Research output: Contribution to journalArticle

23 Citations (Scopus)
2013
29 Citations (Scopus)

Histone deacetylase inhibitor AR42 regulates telomerase activity in human glioma cells via an Akt-dependent mechanism

Yang, Y. L., Huang, P. H., Chiu, H. C., Kulp, S. K., Chen, C. S., Kuo, C. J., Chen, H. D. & Chen, C. S., 2013 May 24, In : Biochemical and Biophysical Research Communications. 435, 1, p. 107-112 6 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Immobilization of the nematode caenorhabditis elegans with addressable light-induced heat knockdown (ALINK)

Chuang, H. S., Chen, H. Y., Chen, C. S. & Chiu, W. T., 2013 Aug 7, In : Lab on a Chip. 13, 15, p. 2980-2989 10 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

SESN-1 is a positive regulator of lifespan in Caenorhabditis elegans

Yang, Y. L., Loh, K. S., Liou, B. Y., Chu, I. H., Kuo, C. J., Chen, H. D. & Chen, C. S., 2013 Mar 1, In : Experimental Gerontology. 48, 3, p. 371-379 9 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)
2012

Genome sequence of a novel human pathogen, Aeromonas aquariorum

Wu, C. J., Wang, H. C., Chen, C. S., Shu, H. Y., Kao, A. W., Chen, P. L. & Ko, W. C., 2012 Aug 1, In : Journal of Bacteriology. 194, 15, p. 4114-4115 2 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)
2010

WWP-1 is a novel modulator of the DAF-2 insulin-like signaling network involved in pore-forming toxin cellular defenses in Caenorhabditis elegans

Chen, C. S., Bellier, A., Kao, C. Y., Yang, Y. L., Chen, H. D., Los, F. C. O. & Aroian, R. V., 2010 Mar 2, In : PloS one. 5, 3, e9494.

Research output: Contribution to journalArticle

33 Citations (Scopus)
2009

Hypoxia and the hypoxic response pathway protect against pore-forming toxins in C. elegans

Bellier, A., Chen, C. S., Kao, C. Y., Cinar, H. N. & Aroian, R. V., 2009 Dec 1, In : PLoS pathogens. 5, 12, e1000689.

Research output: Contribution to journalArticle

65 Citations (Scopus)
2008

Expression of Cry5B protein from Bacillus thuringiensis in plant roots confers resistance to root-knot nematode

Li, X. Q., Tan, A., Voegtline, M., Bekele, S., Chen, C-S. & Aroian, R. V., 2008 Oct 1, In : Biological Control. 47, 1, p. 97-102 6 p.

Research output: Contribution to journalArticle

43 Citations (Scopus)
2007

Histone deacetylase inhibitors sensitize prostate cancer cells to agents that produce DNA double-strand breaks by targeting Ku70 acetylation

Chen, C. S., Wang, Y. C., Yang, H. C., Huang, P. H., Kulp, S. K., Yang, C. C., Lu, Y. S., Matsuyama, S., Chen, C. Y. & Chen, C. S., 2007 Jun 1, In : Cancer Research. 67, 11, p. 5318-5327 10 p.

Research output: Contribution to journalArticle

141 Citations (Scopus)

Peroxisome proliferator-activated receptor γ-independent suppression of androgen receptor expression by troglitazone mechanism and pharmacologic exploitation

Yang, C. C., Wang, Y. C., Wei, S., Lin, L. F., Chen, C. S., Lee, C. C., Lin, C. C. & Chen, C. S., 2007 Apr 1, In : Cancer Research. 67, 7, p. 3229-3238 10 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)
2006

Antitumor effects of a novel phenylbutyrate-based histone deacetylase inhibitor, (S)-HDAC-42, in prostate cancer

Kulp, S. K., Chen, C. S., Wang, D. S., Chen, C. Y. & Chen, C. S., 2006 Sep 1, In : Clinical Cancer Research. 12, 17, p. 5199-5206 8 p.

Research output: Contribution to journalArticle

79 Citations (Scopus)
Open Access

Overcoming trastuzumab resistance in HER2-overexpressing breast cancer cells by using a novel celecoxib-derived phosphoinositide-dependent kinase-1 inhibitor

Tseng, P. H., Wang, Y. C., Weng, S. C., Weng, J. R., Chen, C. S., Brueggemeier, R. W., Shapiro, C. L., Chen, C. Y., Dunn, S. E., Pollak, M. & Chen, C. S., 2006 Nov 24, In : Molecular Pharmacology. 70, 5, p. 1534-1541 8 p.

Research output: Contribution to journalArticle

61 Citations (Scopus)

Peroxisome proliferator-activated receptor γ-independent repression of prostate-specific antigen expression by thiazolidinediones in prostate cancer cells

Yang, C. C., Ku, C. Y., Wei, S., Shiau, C. W., Chen, C-S., Pinzone, J. J., Ringel, M. D. & Chen, C. S., 2006 May 1, In : Molecular Pharmacology. 69, 5, p. 1564-1570 7 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Targeting histone deacetylase in cancer therapy

Lin, H. Y., Chen, C. S., Lin, S. P., Weng, J. R. & Chen, C. S., 2006 Jul 1, In : Medicinal Research Reviews. 26, 4, p. 397-413 17 p.

Research output: Contribution to journalReview article

199 Citations (Scopus)
2005

Histone acetylation-independent effect of histone deacetylase inhibitors on Akt through the reshuffling of protein phosphatase 1 complexes

Chen, C. S., Weng, S. C., Tseng, P. H., Lin, H. P. & Chen, C. S., 2005 Dec 1, In : Journal of Biological Chemistry. 280, 46, p. 38879-38887 9 p.

Research output: Contribution to journalArticle

199 Citations (Scopus)

Structure-based optimization of phenylbutyrate-derived histone deacetylase inhibitors

Lu, Q., Wang, D. S., Chen, C-S., Hu, Y. D. & Chen, C. S., 2005 Aug 25, In : Journal of Medicinal Chemistry. 48, 17, p. 5530-5535 6 p.

Research output: Contribution to journalArticle

70 Citations (Scopus)

Thiazolidenediones mediate apoptosis in prostate cancer cells in part through inhibition of Bcl-xL/Bcl-2 functions independently of PPARγ

Shiau, C. W., Yang, C. C., Kulp, S. K., Chen, K. F., Chen, C. S., Huang, J. W. & Chen, C. S., 2005 Feb 15, In : Cancer Research. 65, 4, p. 1561-1569 9 p.

Research output: Contribution to journalArticle

178 Citations (Scopus)
2004

Growth inhibitory effects of celecoxib in human umbilical vein endothelial cells are mediated through G 1 arrest via multiple signaling mechanisms

Lin, H. P., Kulp, S. K., Tseng, P. H., Yang, Y. T., Yang, C. C., Chen, C-S. & Chen, C. S., 2004 Dec 1, In : Molecular Cancer Therapeutics. 3, 12, p. 1671-1680 10 p.

Research output: Contribution to journalArticle

56 Citations (Scopus)

Selective efficacy of depsipeptide in a xenograft model of Epstein-Barr virus-positive lymphoproliferative disorder

Roychowdhury, S., Baiocchi, R. A., Vourganti, S., Bhatt, D., Blaser, B. W., Freud, A. G., Chou, J., Chen, C. S., Xiao, J. J., Parthun, M., Chan, K. K., Eisenbeis, C. F., Ferketich, A. K., Grever, M. R., Chen, C. S. & Caligiuri, M. A., 2004 Oct 6, In : Journal of the National Cancer Institute. 96, 19, p. 1447-1457 11 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Zn2+-Chelating Motif-Tethered Short-Chain Fatty Acids as a Novel Class of Histone Deacetylase Inhibitors

Lu, Q., Yang, Y. T., Chen, C-S., Davis, M., Byrd, J. C., Etherton, M. R., Umar, A. & Chen, C. S., 2004 Jan 15, In : Journal of Medicinal Chemistry. 47, 2, p. 467-474 8 p.

Research output: Contribution to journalArticle

90 Citations (Scopus)
2003

Bcl-xL mediates a survival mechanism independent of the phosphoinositide 3-kinase/Akt pathway in prostate cancer cells

Yang, C. C., Lin, H. P., Chen, C. S., Yang, Y. T., Tseng, P. H., Rangnekar, V. M. & Chen, C. S., 2003 Jul 11, In : Journal of Biological Chemistry. 278, 28, p. 25872-25878 7 p.

Research output: Contribution to journalArticle

53 Citations (Scopus)
2000

Characterization of the distal tail fiber locus and determination of the receptor for phage AR1, which specifically infects Escherichia coli O157:H7

Yu, S. L., Ko, K. L., Chen, C-S., Chang, Y. C. & Syu, W. J., 2000 Nov 20, In : Journal of Bacteriology. 182, 21, p. 5962-5968 7 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)