• 4469 Citations
  • 37 h-Index
1978 …2019
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Research Output 1978 2019

  • 4469 Citations
  • 37 h-Index
  • 143 Article
  • 7 Patent
  • 1 Conference contribution
  • 1 Comment/debate
2019
1 Citation (Scopus)

Amelioration of experimentally induced arthritis by reducing reactive oxygen species production through the intra-articular injection of water-soluble fullerenol

Kuo, W. S., Weng, C-T., Chen, J. H., Wu, C-L., Shiau, A-L., Hsieh, J. L., So, E. C., Wu, P-T. & Chen, S. Y., 2019 Jun, In : Nanomaterials. 9, 6, 909.

Research output: Contribution to journalArticle

Open Access
Reactive Oxygen Species
Oxygen
Water
Nitric oxide
Cartilage

Expression of prothymosin α in lung cancer is associated with squamous cell carcinoma and smoking

Kuo, Y. H., Shiau, A. L., Tung, C. L., Su, Y. C., Li, C. F., Su, B. H., Tsao, C. J., Wu, C. L., Feng, Y. H. & Wu, P., 2019 Jun, In : Oncology Letters. 17, 6, p. 5740-5746 7 p.

Research output: Contribution to journalArticle

Open Access
Squamous Cell Carcinoma
Lung Neoplasms
Smoking
Non-Small Cell Lung Carcinoma
Neoplasms

Inhibition of cd44 induces apoptosis, inflammation, and matrix metalloproteinase expression in tendinopathy

Wu, P. T., Su, W. R., Li, C. L., Hsieh, J. L., Ma, C. H., Wu, C. L., Kuo, L. C., Jou, I. M. & Chen, S. Y., 2019 Jan 1, In : Journal of Biological Chemistry. 294, 52, p. 20177-20184 8 p.

Research output: Contribution to journalArticle

Tendinopathy
Matrix Metalloproteinases
Apoptosis
Inflammation
Tendons

Oct4 upregulates osteopontin via Egr1 and is associated with poor outcome in human lung cancer

Feng, Y. H., Su, Y. C., Lin, S. F., Lin, P. R., Wu, C. L., Tung, C. L., Li, C. F., Shieh, G. S. & Shiau, A. L., 2019 Aug 9, In : BMC cancer. 19, 1, 791.

Research output: Contribution to journalArticle

Open Access
Osteopontin
Lung Neoplasms
Up-Regulation
Growth
Genes
Open Access
Phosphoric Monoester Hydrolases
Urinary Bladder Neoplasms
Nuclear Localization Signals
Proteins
Ubiquitination

Prothymosin α promotes STAT3 acetylation to induce cystogenesis in Pkd1-deficient mice

Chen, Y. C., Su, Y. C., Shieh, G. S., Su, B. H., Su, W. C., Huang, P. H., Jiang, S. T., Shiau, A. L. & Wu, C. L., 2019 Nov 1, In : FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33, 11, p. 13051-13061 11 p.

Research output: Contribution to journalArticle

Acetylation
Polycystic Kidney Diseases
STAT3 Transcription Factor
Kidney
Cysts
2018
4 Citations (Scopus)

Elovl6 is a negative clinical predictor for liver cancer and knockdown of Elovl6 reduces murine liver cancer progression

Su, Y. C., Feng, Y. H., Wu, H. T., Huang, Y. S., Tung, C. L., Wu, P., Chang, C. J., Shiau, A. L. & Wu, C. L., 2018 Dec 1, In : Scientific reports. 8, 1, 6586.

Research output: Contribution to journalArticle

Liver Neoplasms
Hepatocellular Carcinoma
Neoplasms
Fatty Acids
Monounsaturated Fatty Acids
1 Citation (Scopus)

Estrogen and mechanical loading-related regulation of estrogen receptor-β and apoptosis in tendinopathy

Hsieh, J. L., Jou, I. M., Wu, C. L., Wu, P. T., Shiau, A. L., Chong, H. E., Lo, Y. T., Shen, P. C. & Chen, S. Y., 2018 Oct, In : PloS one. 13, 10, e0204603.

Research output: Contribution to journalArticle

Tendinopathy
Estrogen Receptors
estrogens
Tendons
Estrogens
2017
13 Citations (Scopus)

Chemotherapeutics-induced Oct4 expression contributes to drug resistance and tumor recurrence in bladder cancer

Lu, C. S., Shieh, G. S., Wang, C. T., Su, B. H., Su, Y. C., Chen, Y. C., Su, W. C., Wu, P., Yang, W. H., Shiau, A. L. & Wu, C. L., 2017 Jan 1, In : Oncotarget. 8, 19, p. 30844-30858 15 p.

Research output: Contribution to journalArticle

Drug Resistance
Urinary Bladder Neoplasms
Cisplatin
Recurrence
Neoplasms
Manuscripts
Gastroenterology
Serum
corrigendum
Non-alcoholic Fatty Liver Disease
6 Citations (Scopus)
Neuroprotective Agents
Stroke
Tumor Necrosis Factor-alpha
Middle Cerebral Artery Infarction
Interleukin-10
1 Citation (Scopus)
Tendinopathy
Weight-Bearing
Hindlimb
Collagenases
Achilles Tendon
10 Citations (Scopus)
Hepatocellular Carcinoma
cancer
mice
Bearings (structural)
Catenins
14 Citations (Scopus)

IL-6 ameliorates acute lung injury in influenza virus infection

Yang, M. L., Wang, C. T., Yang, S. J., Leu, C. H., Chen, S. H., Wu, C. L. & Shiau, A. L., 2017 Mar 6, In : Scientific reports. 7, 43829.

Research output: Contribution to journalArticle

Acute Lung Injury
Virus Diseases
Orthomyxoviridae
Interleukin-6
Lung
4 Citations (Scopus)

Knockdown of toll-like receptor 4 signaling pathways ameliorate bone graft rejection in a mouse model of allograft transplantation

Hsieh, J. L., Shen, P. C., Wu, P-T., Jou, I. M., Wu, C-L., Shiau, A-L., Wang, C-R., Chong, H. E., Chuang, S. H., Peng, J. S. & Chen, S. Y., 2017 Apr 10, In : Scientific reports. 7, 46050.

Research output: Contribution to journalArticle

Toll-Like Receptor 4
Graft Rejection
Allografts
Transplantation
Bone and Bones
9 Citations (Scopus)

One-dimensional poly(L-lysine)-block-poly(L-threonine) assemblies exhibit potent anticancer activity by enhancing membranolysis

Chen, Y. F., Shiau, A. L., Chang, S-J., Fan, N. S., Wang, C. T., Wu, C. L. & Jan, J. S., 2017 Jun 1, In : Acta Biomaterialia. 55, p. 283-295 13 p.

Research output: Contribution to journalArticle

Threonine
Lysine
Neoplasms
Membranes
Mitochondrial Membranes

P53-derived hybrid peptides induce apoptosis of synovial fibroblasts in the rheumatoid joint

Chen, S. Y., Shiau, A. L., Wu, C. L. & Wang, C. R., 2017 Jan 1, In : Oncotarget. 8, 70, p. 115413-115419 7 p.

Research output: Contribution to journalArticle

Fibroblasts
Joints
Apoptosis
Peptides
Rheumatoid Arthritis
2016
32 Citations (Scopus)

Amelioration of Experimental Autoimmune Arthritis Through Targeting of Synovial Fibroblasts by Intraarticular Delivery of MicroRNAs 140-3p and 140-5p

Peng, J. S., Chen, S. Y., Wu, C. L., Chong, H. E., Ding, Y. C., Shiau, A. L. & Wang, C. R., 2016 Feb 1, In : Arthritis and Rheumatology. 68, 2, p. 370-381 12 p.

Research output: Contribution to journalArticle

Experimental Arthritis
MicroRNAs
Fibroblasts
Arthritis
Rheumatoid Arthritis
16 Citations (Scopus)

A novel hepatokine, HFREP1, plays a crucial role in the development of insulin resistance and type 2 diabetes

Wu, H. T., Ou, H. Y., Hung, H. C., Su, Y. C., Lu, F. H., Wu, J. S., Yang, Y. C., Wu, C. L. & Chang, C. J., 2016 Aug 1, In : Diabetologia. 59, 8, p. 1732-1742 11 p.

Research output: Contribution to journalArticle

Fibrinogen
Type 2 Diabetes Mellitus
Insulin Resistance
Hepatocytes
Glucose Intolerance
12 Citations (Scopus)

Elovl6 is a poor prognostic predictor in breast cancer

Feng, Y. H., Chen, W. Y., Kuo, Y. H., Tung, C. L., Tsao, C. J., Shiau, A. L. & Wu, C. L., 2016 Jul, In : Oncology Letters. 12, 1, p. 207-212 6 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Obesity
Lymph Nodes
Lipogenesis
Mastectomy
4 Citations (Scopus)

Intraarticular overexpression of Smad7 ameliorates experimental arthritis

Chen, S. Y., Shiau, A. L., Wu, C. L. & Wang, C. R., 2016 Oct 12, In : Scientific reports. 6, 35163.

Research output: Contribution to journalArticle

Experimental Arthritis
Joints
Crohn Disease
Rheumatoid Arthritis
Arthritis
8 Citations (Scopus)

Over-expression of prothymosin-α antagonizes TGFβ signalling to promote the development of emphysema

Su, B. H., Tseng, Y. L., Shieh, G. S., Chen, Y. C., Wu, P., Shiau, A. L. & Wu, C. L., 2016 Feb 1, In : Journal of Pathology. 238, 3, p. 412-422 11 p.

Research output: Contribution to journalArticle

Emphysema
Transforming Growth Factors
Tissue Inhibitor of Metalloproteinase-3
Matrix Metalloproteinase 3
Histone Deacetylases
2015
5 Citations (Scopus)

Acarbose Decreases the Rheumatoid Arthritis Risk of Diabetic Patients and Attenuates the Incidence and Severity of Collagen-induced Arthritis in Mice

Chen, H. H., Chen, D. Y., Chao, Y. H., Chen, Y. M., Wu, C. L., Lai, K. L., Lin, C. H. & Lin, C. C., 2015 Dec 18, In : Scientific reports. 5, 18288.

Research output: Contribution to journalArticle

Acarbose
Experimental Arthritis
Rheumatoid Arthritis
Incidence
Diabetes Mellitus
4 Citations (Scopus)
Intra-Articular Injections
Experimental Arthritis
Epidermal Growth Factor Receptor
Protein-Tyrosine Kinases
Joints
3 Citations (Scopus)

Etoposide enhances antitumor efficacy of MDR1-driven oncolytic adenovirus through autoupregulation of the MDR1 promoter activity

Su, B. H., Shieh, G. S., Tseng, Y. L., Shiau, A. L. & Wu, C. L., 2015 Jan 1, In : Oncotarget. 6, 35, p. 38308-38326 19 p.

Research output: Contribution to journalArticle

Multiple Drug Resistance
Etoposide
Adenoviridae
Neoplasms
Combination Drug Therapy
8 Citations (Scopus)

Kallistatin ameliorates influenza virus pathogenesis by inhibition of kallikrein-related peptidase 1-mediated cleavage of viral hemagglutinin

Leu, C. H., Yang, M. L., Chung, N. H., Huang, Y. J., Su, Y. C., Chen, Y. C., Lin, C. C., Shieh, G. S., Chang, M. Y., Wang, S. W., Chang, Y., Chao, J., Chao, L., Wu, C. L. & Shiau, A. L., 2015 Sep 1, In : Antimicrobial agents and chemotherapy. 59, 9, p. 5619-5630 12 p.

Research output: Contribution to journalArticle

Viral Hemagglutinins
Kallikreins
Orthomyxoviridae
Peptide Hydrolases
Hemagglutinins
17 Citations (Scopus)

Naringenin inhibits dendritic cell maturation and has therapeutic effects in a murine model of collagen-induced arthritis

Li, Y. R., Chen, D. Y., Chu, C. L., Li, S., Chen, Y. K., Wu, C-L. & Lin, C. C., 2015 Dec 1, In : Journal of Nutritional Biochemistry. 26, 12, p. 1467-1478 12 p.

Research output: Contribution to journalArticle

Experimental Arthritis
Therapeutic Uses
Dendritic Cells
Collagen
T-cells
8 Citations (Scopus)

Potent antitumor activity of Oct4 and hypoxia dual-regulated oncolytic adenovirus against bladder cancer

Lu, C. S., Hsieh, J. L., Lin, C. Y., Tsai, H. W., Su, B. H., Shieh, G. S., Su, Y. C., Lee, C. H., Chang, M. Y., Wu, C. L. & Shiau, A. L., 2015 Apr 4, In : Gene Therapy. 22, 4, p. 305-315 11 p.

Research output: Contribution to journalArticle

Urinary Bladder Neoplasms
Adenoviridae
Response Elements
Neoplastic Stem Cells
Cell Hypoxia
4 Citations (Scopus)

Prothymosin-α overexpression contributes to the development of insulin resistance

Su, Y. C., Ou, H. Y., Wu, H. T., Wu, P., Chen, Y. C., Su, B. H., Shiau, A. L., Chang, C. J. & Wu, C. L., 2015 Nov, In : Journal of Clinical Endocrinology and Metabolism. 100, 11, p. 4114-4123 10 p.

Research output: Contribution to journalArticle

Insulin Resistance
Insulin
Medical problems
Toll-Like Receptor 4
High Fat Diet
16 Citations (Scopus)

Transcription factor snail regulates tumor necrosis factor α-mediated synovial fibroblast activation in the rheumatoid joint

Chen, S. Y., Shiau, A. L., Li, Y. T., Lin, C. C., Jou, I. M., Liu, M. F., Wu, C. L. & Wang, C. R., 2015 Jan 1, In : Arthritis and Rheumatology. 67, 1, p. 39-50 12 p.

Research output: Contribution to journalArticle

Experimental Arthritis
Tumor Necrosis Factor-alpha
Fibroblasts
Joints
Synovial Membrane
2014
6 Citations (Scopus)
Nonesterified Fatty Acids
Liver
Hep G2 Cells
High Fat Diet
Sterol Regulatory Element Binding Protein 1
4 Citations (Scopus)

Adenovirus-mediated prothymosin α gene transfer inhibits the development of atherosclerosis in apoe-deficient mice

Chang, M. Y., Yang, Y. S., Tsai, M. L., Lee, C. H., Chang, C. J., Shiau, A. L. & Wu, C. L., 2014 Mar 15, In : International Journal of Biological Sciences. 10, 4, p. 358-366 9 p.

Research output: Contribution to journalArticle

gene transfer
Apolipoproteins E
Adenoviridae
atherosclerosis
antioxidant
8 Citations (Scopus)

High-level β1-integrin expression in a subpopulation of highly tumorigenic oral cancer cells

Lin, H. C., Wu, C. L., Chen, Y. L., Huang, J. S., Wong, T. Y. & Yuan, K., 2014 Jan 1, In : Clinical Oral Investigations. 18, 4, p. 1277-1284 8 p.

Research output: Contribution to journalArticle

Mouth Neoplasms
Integrins
Squamous Cell Carcinoma
Neoplasms
Cell Migration Assays
4 Citations (Scopus)

Loss of nuclear prothymosin-α expression is associated with disease progression in human superficial bladder cancer

Tsai, Y. S., Jou, Y. C., Tung, C. L., Lin, C. T., Shen, C. H., Chen, S. Y., Tsai, H. T., Lai, C. L., Wu, C. L. & Tzai, T. S., 2014 Jun, In : Virchows Archiv. 464, 6, p. 717-724 8 p.

Research output: Contribution to journalArticle

Urinary Bladder Neoplasms
Disease Progression
Multivariate Analysis
Chi-Square Distribution
Proportional Hazards Models
28 Citations (Scopus)

Scutellaria barbata inhibits angiogenesis through downregulation of HIF-1 α in lung tumor

Shiau, A. L., Shen, Y. T., Hsieh, J. L., Wu, C. L. & Lee, C. H., 2014 Apr, In : Environmental Toxicology. 29, 4, p. 363-370 8 p.

Research output: Contribution to journalArticle

Scutellaria
Hypoxia-Inducible Factor 1
hypoxia
tumor
Tumors
7 Citations (Scopus)

Zhankuic acid A as a novel JAK2 inhibitor for the treatment of concanavalin A-induced hepatitis

Chen, Y. F., Wang, S. H., Chang, S-J., Shiau, A. L., Her, L. S., Shieh, G. S., Chen, C. F., Chang, C. C., Su, Y. C., Wu, C. L. & Wu, T-S., 2014 Sep 15, In : Biochemical Pharmacology. 91, 2, p. 217-230 14 p.

Research output: Contribution to journalArticle

Janus Kinase 2
Concanavalin A
Hepatitis
Therapeutics
Liver
17 Citations (Scopus)

Zhankuic acid a isolated from taiwanofungus camphoratus is a novel selective TLR4/MD-2 antagonist with anti-inflammatory properties

Chen, Y. F., Shiau, A. L., Wang, S. H., Yang, J. S., Chang, S-J., Wu, C. L. & Wu, T-S., 2014 Mar 15, In : Journal of Immunology. 192, 6, p. 2778-2786 9 p.

Research output: Contribution to journalArticle

Anti-Inflammatory Agents
Acids
Gram-Negative Bacterial Infections
Inflammation
zhankuic acid A
12 Citations (Scopus)

α-Melanocyte-stimulating hormone inhibits angiogenesis through attenuation of VEGF/VEGFR2 signaling pathway

Weng, W. T., Huang, S. C., Ma, Y. L., Chan, H. H., Lin, S. W., Wu, J. C., Wu, C. Y., Wen, Z. H., Wang, E. M., Wu, C. L. & Tai, M. H., 2014 Jun, In : Biochimica et Biophysica Acta - General Subjects. 1840, 6, p. 1850-1860 11 p.

Research output: Contribution to journalArticle

Melanocyte-Stimulating Hormones
Vascular Endothelial Growth Factor Receptor-2
Vascular Endothelial Growth Factor Receptor
Vascular Endothelial Growth Factor A
Endothelial cells
2013
19 Citations (Scopus)

CD8+ T cell-induced expression of tissue inhibitor of metalloproteinses-1 exacerbated osteoarthritis

Hsieh, J. L., Shiau, A. L., Lee, C. H., Yang, S. J., Lee, B. O., Jou, I. M., Wu, C. L., Chen, S. H. & Shen, P. C., 2013 Oct 8, In : International journal of molecular sciences. 14, 10, p. 19951-19970 20 p.

Research output: Contribution to journalArticle

T-cells
Tissue Inhibitor of Metalloproteinase-1
Osteoarthritis
inhibitors
Tissue
49 Citations (Scopus)

Focused-ion-beam-fabricated Au/Ag multilayered nanorod array as SERS-active substrate for virus strain detection

Sivashanmugan, K., Liao, J-D., You, J. W. & Wu, C-L., 2013 Mar 25, In : Sensors and Actuators, B: Chemical. 181, p. 361-367 7 p.

Research output: Contribution to journalArticle

Focused ion beams
viruses
Nanorods
Viruses
nanorods
6 Citations (Scopus)

Plasma thymosin-α1 level as a potential biomarker in urothelial and renal cell carcinoma

Jou, Y. C., Tsai, Y. S., Hsieh, H. Y., Chen, S. Y., Tsai, H. T., Chen, K. J., Wang, S. T., Shiau, A. L., Wu, C. L. & Tzai, T. S., 2013 Nov 1, In : Urologic Oncology: Seminars and Original Investigations. 31, 8, p. 1806-1811 6 p.

Research output: Contribution to journalArticle

Thymosin
Renal Cell Carcinoma
Biomarkers
Carcinoma
Urinary Bladder Neoplasms
16 Citations (Scopus)

Prothymosin α overexpression contributes to the development of pulmonary emphysema

Su, B. H., Tseng, Y. L., Shieh, G. S., Chen, Y. C., Shiang, Y. C., Wu, P., Li, K. J., Yen, T. H., Shiau, A. L. & Wu, C. L., 2013 Jun 12, In : Nature communications. 4, 1906.

Research output: Contribution to journalArticle

emphysema
Pulmonary Emphysema
Emphysema
Smoke
Tobacco Products
22 Citations (Scopus)

TGF-β1 conjugated to gold nanoparticles results in protein conformational changes and attenuates the biological function

Tsai, Y-S., Chen, Y-H., Cheng, P. C., Tsai, H. T., Shiau, A-L., Tzai, T. S. & Wu, C-L., 2013 Jun 24, In : Small. 9, 12, p. 2119-2128 10 p.

Research output: Contribution to journalArticle

Gold
Transforming Growth Factor beta
Nanoparticles
Proteins
Tumors
21 Citations (Scopus)

The role of Hepassocin in the development of non-alcoholic fatty liver disease

Wu, H. T., Lu, F-H., Ou, H-Y., Su, Y. C., Hung, H-C., Wu, J-S., Yang, Y-C., Wu, C-L. & Chang, C-J., 2013 Nov 1, In : Journal of Hepatology. 59, 5, p. 1065-1072 8 p.

Research output: Contribution to journalArticle

Lipids
Mitogen-Activated Protein Kinase 3
Liver
Mitogen-Activated Protein Kinase 1
Hep G2 Cells
2012
11 Citations (Scopus)

Acquisition of an enhanced aggressive phenotype in human lung cancer cells selected by suboptimal doses of cisplatin following cell deattachment and reattachment

Hsieh, J. L., Lu, C. S., Huang, C. L., Shieh, G. S., Su, B. H., Su, Y. C., Lee, C. H., Chang, M. Y., Wu, C. L. & Shiau, A. L., 2012 Aug 1, In : Cancer Letters. 321, 1, p. 36-44 9 p.

Research output: Contribution to journalArticle

Cisplatin
Lung Neoplasms
Phenotype
Aptitude
gemcitabine
79 Citations (Scopus)

Amelioration of collagen-induced arthritis in mice by lentivirus-mediated silencing of microRNA-223

Li, Y. T., Chen, S. Y., Wang, C. R., Liu, M. F., Lin, C. C., Jou, I. M., Shiau, A. L. & Wu, C. L., 2012 Oct 1, In : Arthritis and Rheumatism. 64, 10, p. 3240-3245 6 p.

Research output: Contribution to journalArticle

Lentivirus
Experimental Arthritis
MicroRNAs
Rheumatoid Arthritis
Macrophage Colony-Stimulating Factor Receptors
44 Citations (Scopus)

MicroRNA-21-mediated regulation of Sprouty2 protein expression enhances the cytotoxic effect of 5-fluorouracil and metformin in colon cancer cells

Feng, Y. H., Wu, C. L., Shiau, A. L., Lee, J. C., Chang, J. G., Lu, P. J., Tung, C. L., Feng, L. Y., Huang, W. T. & Tsao, C. J., 2012 May 1, In : International journal of molecular medicine. 29, 5, p. 920-926 7 p.

Research output: Contribution to journalArticle

Metformin
MicroRNAs
Fluorouracil
Colonic Neoplasms
Proteins
29 Citations (Scopus)

Multivalent structure of galectin-1-nanogold complex serves as potential therapeutics for rheumatoid arthritis by enhancing receptor clustering

Huang, Y. J., Shiau, A. L., Chen, S. Y., Chen, Y. L., Wang, C. R., Tsai, C. Y., Chang, M. Y., Li, Y. T., Leu, C. H. & Wu, C. L., 2012 Jan, In : European Cells and Materials. 23, p. 170-181 12 p.

Research output: Contribution to journalArticle

Galectin 1
Nanoparticles
Cluster Analysis
Rheumatoid Arthritis
Ligands
25 Citations (Scopus)

Suppression of collagen-induced arthritis by intra-articular lentiviral vector-mediated delivery of Toll-like receptor 7 short hairpin RNA gene

Chen, S. Y., Shiau, A-L., Li, Y. T., Lin, Y-S., Lee, C. H., Wu, C-L. & Wang, C-R., 2012 Jul 1, In : Gene Therapy. 19, 7, p. 752-760 9 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 7
Experimental Arthritis
Vascular Endothelial Growth Factor A
Small Interfering RNA
Joints
12 Citations (Scopus)
Orthomyxoviridae
Viruses
Encephalomyocarditis virus
Raman Spectrum Analysis
Influenza A virus