Projects per year
Personal profile
Education
- 1996 PhD. Institute of Immunolgy, Harvard University, USA
Experience
- 1996.07~1997.01 Postdoctoral Research/Brigham and Women’s Hospital/Harvard University
- 1997.02~Present Attending Physician/Divisionof Pediatric Allergy and Immunology/National Cheng Kung University Hospital
- 1998.08~2002.07 Assistant Professor/Department of Microbiology and Immunology, NCKU
- 2002.03~2004.07 Head of Pediatric Allergy and Immunology Division/National Cheng Kung University Hospital
- 2002.08~2007.07 Associate Professor/Department of Microbiology and Immunology, NCKU
- 2007.08~2010.07 Professor/Department of Microbiology and Immunology, NCKU
- 2010.08~present Editor/ Journal of Microbiology, Immunology and Infection
- 2011.08~2017.07 Professor Director/ Graduate institute of clinical medicine & clinical medicine researcher center, NCKU
- 2011.08~Present Professor
- 2016.08~ Distinguished Professor
Research Interests
The research in Prof. Chi-Chang Shieh’s laboratory focuses on the immune mechanisms underlying the tissue inflammation of human diseases including allergic asthma, immune mediated arthritis and autoimmune reactions in immunodeficiency diseases.
His recent laboratory research took advantage of the resources in the campuses of National Cheng Kung University and Southern Facility of National Laboratory Animal Center, both located in Tainan City, to elucidate the molecular and cellular mechanism leading to tissue inflammation in patients with low production of reactive oxygen species (ROS). Moreover, he devised methods aimed to correct the low production of ROS by leukocytes, which is the cause of the primary immunodeficiency disease chronic granulomatous disease (CGD), using state-of-the-art technologies and cutting-edge knowledge in leukocyte biology.
The main accomplishments of his research are concisely described as follows:
1. To establish a clinic of human primary immunodeficiency for diagnosis, treatment and research for this group of difficult diseases.
2. To develop the research for secondary immunodeficiency 3. To unravel the mechanisms underlying redox regulation of immune responses 4. Development of organelle-specific treatment for immunological diseases
His recent laboratory research took advantage of the resources in the campuses of National Cheng Kung University and Southern Facility of National Laboratory Animal Center, both located in Tainan City, to elucidate the molecular and cellular mechanism leading to tissue inflammation in patients with low production of reactive oxygen species (ROS). Moreover, he devised methods aimed to correct the low production of ROS by leukocytes, which is the cause of the primary immunodeficiency disease chronic granulomatous disease (CGD), using state-of-the-art technologies and cutting-edge knowledge in leukocyte biology.
The main accomplishments of his research are concisely described as follows:
1. To establish a clinic of human primary immunodeficiency for diagnosis, treatment and research for this group of difficult diseases.
2. To develop the research for secondary immunodeficiency 3. To unravel the mechanisms underlying redox regulation of immune responses 4. Development of organelle-specific treatment for immunological diseases
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Network
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Projects
- 20 Finished
Research Output
A novel pathogenic mutation on Interleukin-7 receptor leading to severe combined immunodeficiency identified with newborn screening and whole exome sequencing
Liao, C. Y., Yu, H. W., Cheng, C. N., Chen, J. S., Lin, C. W., Chen, P. C. & Shieh, C. C., 2020 Feb, In : Journal of Microbiology, Immunology and Infection. 53, 1, p. 99-105 7 p.Research output: Contribution to journal › Article
4
Citations
(Scopus)
How mycobacteria take advantage of the weakness in human immune system in the modern world
Chao, W. C., Yen, C. L., Wu, C. H. & Shieh, C. C., 2020 Apr, In : Journal of Microbiology, Immunology and Infection. 53, 2, p. 209-215 7 p.Research output: Contribution to journal › Review article
Open Access
Bidirectional relationship between systemic lupus erythematosus and non-Hodgkin's lymphoma: A nationwide population-based study
Wang, L. H., Wang, W. M., Lin, S. H. & Shieh, C. C., 2019 Jul 1, In : Rheumatology (United Kingdom). 58, 7, p. 1245-1249 5 p.Research output: Contribution to journal › Article
1
Citation
(Scopus)
Bronchoscopy-guided bronchial epithelium sampling as a tool for selecting the optimal biologic treatment in a patient with severe asthma: A case report
Kuo, C. W., Liao, X. M., Huang, Y. C., Chang, H. Y. & Shieh, C. C., 2019 Nov 27, In : Allergy, Asthma and Clinical Immunology. 15, 1, 76.Research output: Contribution to journal › Article
Open Access
Increased ILC3s associated with higher levels of IL‐1β aggravates inflammatory arthritis in mice lacking phagocytic NADPH oxidase
Chan, T., Yen, C., Huang, Y., Lo, P., Nigrovic, P. A., Cheng, C., Wang, W., Wu, S. & Shieh, C-C., 2019 Jul 26, In : European Journal of Immunology.Research output: Contribution to journal › Article
1
Citation
(Scopus)
Thesis
Development of novel immune mechanism-based therapies for autoimmune uveitis using a mouse model of experimental autoimmune uveitis
Author: 聖民, 許., 2014 Aug 29Supervisor: Shieh, C. (Supervisor)
Student thesis: Doctoral Thesis
Redox Regulation of Neutrophil Extracellular Traps Formation and IL-1β Processing in Serum-induced Arthritis
Author: 正綱, 許., 2018 Jul 18Supervisor: Shieh, C. (Supervisor)
Student thesis: Master's Thesis
The immunopathogensis underlying the higher severity and mortality in dengue virus infection in diabetes mellitus
Author: 松林, 劉., 2018 Aug 8Supervisor: Shieh, C. (Supervisor)
Student thesis: Master's Thesis
The role of leukocyte NADPH oxidase in the regulation of IL-1 family cytokines and innate lymphoid cells in serum-induced arthritis
Author: 子頤, 詹., 2017 Jul 20Supervisor: Shieh, C. (Supervisor)
Student thesis: Master's Thesis
The Role of Leukocyte Signal Transduction on the Pathogenesis of Secondary Immunodeficiency in Obesity
Author: 嘉良, 顏., 2014 Aug 15Supervisor: Shieh, C. (Supervisor)
Student thesis: Doctoral Thesis