Projects per year
Personal profile
Education
- 1996 PhD. Institute of Immunolgy, Harvard University, USA
Experience
- 1996.07~1997.01 Postdoctoral Research/Brigham and Women’s Hospital/Harvard University
- 1997.02~Present Attending Physician/Divisionof Pediatric Allergy and Immunology/National Cheng Kung University Hospital
- 1998.08~2002.07 Assistant Professor/Department of Microbiology and Immunology, NCKU
- 2002.03~2004.07 Head of Pediatric Allergy and Immunology Division/National Cheng Kung University Hospital
- 2002.08~2007.07 Associate Professor/Department of Microbiology and Immunology, NCKU
- 2007.08~2010.07 Professor/Department of Microbiology and Immunology, NCKU
- 2010.08~present Editor/ Journal of Microbiology, Immunology and Infection
- 2011.08~2017.07 Professor Director/ Graduate institute of clinical medicine & clinical medicine researcher center, NCKU
- 2011.08~Present Professor
- 2016.08~ Distinguished Professor
Research Interests
The research in Prof. Chi-Chang Shieh’s laboratory focuses on the immune mechanisms underlying the tissue inflammation of human diseases including allergic asthma, immune mediated arthritis and autoimmune reactions in immunodeficiency diseases.
His recent laboratory research took advantage of the resources in the campuses of National Cheng Kung University and Southern Facility of National Laboratory Animal Center, both located in Tainan City, to elucidate the molecular and cellular mechanism leading to tissue inflammation in patients with low production of reactive oxygen species (ROS). Moreover, he devised methods aimed to correct the low production of ROS by leukocytes, which is the cause of the primary immunodeficiency disease chronic granulomatous disease (CGD), using state-of-the-art technologies and cutting-edge knowledge in leukocyte biology.
The main accomplishments of his research are concisely described as follows:
1. To establish a clinic of human primary immunodeficiency for diagnosis, treatment and research for this group of difficult diseases.
2. To develop the research for secondary immunodeficiency 3. To unravel the mechanisms underlying redox regulation of immune responses 4. Development of organelle-specific treatment for immunological diseases
His recent laboratory research took advantage of the resources in the campuses of National Cheng Kung University and Southern Facility of National Laboratory Animal Center, both located in Tainan City, to elucidate the molecular and cellular mechanism leading to tissue inflammation in patients with low production of reactive oxygen species (ROS). Moreover, he devised methods aimed to correct the low production of ROS by leukocytes, which is the cause of the primary immunodeficiency disease chronic granulomatous disease (CGD), using state-of-the-art technologies and cutting-edge knowledge in leukocyte biology.
The main accomplishments of his research are concisely described as follows:
1. To establish a clinic of human primary immunodeficiency for diagnosis, treatment and research for this group of difficult diseases.
2. To develop the research for secondary immunodeficiency 3. To unravel the mechanisms underlying redox regulation of immune responses 4. Development of organelle-specific treatment for immunological diseases
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
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Projects
- 24 Finished
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Deletion of NADPH oxidase 2 attenuates cisplatin-induced acute kidney injury through reducing ROS-induced proximal tubular cell injury and inflammation
Chen, H. C., Hou, H. Y., Sung, J. M. & Shieh, C. C., 2023, In: Frontiers in Medicine. 10, 1097671.Research output: Contribution to journal › Article › peer-review
Open Access -
Postnatal corticosteroid treatment as a risk factor for false positivity in severe combined immunodeficiency newborn screening
Chen, P. S., Lee, J., Pan, H. P., Lin, Y. J., Lin, Y. C., Chang, Y. S., Chen, Y. J., Yen, C. L., Lin, C. W., Chen, C. A. & Shieh, C. C., 2023 Aug, In: Journal of Microbiology, Immunology and Infection. 56, 4, p. 871-874 4 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Pre-existing humoral immunity and CD4+ T cell response correlate with cross-reactivity against SARS-CoV-2 Omicron subvariants after heterologous prime-boost vaccination
Shen, C. F., Fu, Y. C., Ho, T. S., Chen, P. L., Lee, N. Y., Tsai, B. Y., Tsai, P. J., Ko, W. C., Liu, C. C., Cheng, C. M. & Shieh, C. C., 2023 Jun, In: Clinical Immunology. 251, 109342.Research output: Contribution to journal › Article › peer-review
Open Access -
Body-Weight Gain in Women During Smoking Cessation Is a Sex-Specific Predictor of 6-Month Abstinence: A Retrospective Cohort Study
Kuo, C. W., Lin, C. F., Chen, C. Y., Wang, R. H., Chou, C. Y., Cheng, H. J., Wu, J. S., Chen, C. W., Shieh, C. C. & Yu, T., 2022 May 13, In: Frontiers in Public Health. 10, 872220.Research output: Contribution to journal › Article › peer-review
Open Access2 Citations (Scopus) -
Erratum: Bidirectional Relationship Between Primary Sjögren Syndrome and Non-Hodgkin Lymphoma: A Nationwide Taiwanese Population-based Study (J Rheumatol (2020) DOI: 10.3899/jrheum.191027)
Wang, L. H., Wang, W. M., Lin, C. Y., Lin, S. H. & Shieh, C. C., 2022 Oct 1, In: Journal of Rheumatology. 49, 10, p. 1182 1 p.Research output: Contribution to journal › Comment/debate › peer-review
Open Access