• 1754 Citations
  • 20 h-Index
1986 …2020

Research output per year

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Personal profile


  • 1996 PhD. Institute of Immunolgy, Harvard University, USA


  • 1996.07~1997.01 Postdoctoral Research/Brigham and Women’s Hospital/Harvard University
  • 1997.02~Present Attending Physician/Divisionof Pediatric Allergy and Immunology/National Cheng Kung University Hospital
  • 1998.08~2002.07 Assistant Professor/Department of Microbiology and Immunology, NCKU
  • 2002.03~2004.07 Head of Pediatric Allergy and Immunology Division/National Cheng Kung University Hospital
  • 2002.08~2007.07 Associate Professor/Department of Microbiology and Immunology, NCKU
  • 2007.08~2010.07 Professor/Department of Microbiology and Immunology, NCKU
  • 2010.08~present Editor/ Journal of Microbiology, Immunology and Infection
  • 2011.08~2017.07 Professor Director/ Graduate institute of clinical medicine & clinical medicine researcher center, NCKU
  • 2011.08~Present Professor
  • 2016.08~ Distinguished Professor

Research Interests

The research in Prof. Chi-Chang Shieh’s laboratory focuses on the immune mechanisms underlying the tissue inflammation of human diseases including allergic asthma, immune mediated arthritis and autoimmune reactions in immunodeficiency diseases.

His recent laboratory research took advantage of the resources in the campuses of National Cheng Kung University and Southern Facility of National Laboratory Animal Center, both located in Tainan City, to elucidate the molecular and cellular mechanism leading to tissue inflammation in patients with low production of reactive oxygen species (ROS). Moreover, he devised methods aimed to correct the low production of ROS by leukocytes, which is the cause of the primary immunodeficiency disease chronic granulomatous disease (CGD), using state-of-the-art technologies and cutting-edge knowledge in leukocyte biology.

The main accomplishments of his research are concisely described as follows:

1. To establish a clinic of human primary immunodeficiency for diagnosis, treatment and research for this group of difficult diseases.

2. To develop the research for secondary immunodeficiency 3. To unravel the mechanisms underlying redox regulation of immune responses 4. Development of organelle-specific treatment for immunological diseases

Fingerprint Dive into the research topics where Chi-Chang Shieh is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

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Research Output

  • 1754 Citations
  • 20 h-Index
  • 74 Article
  • 3 Comment/debate
  • 2 Review article
  • 2 Patent
  • 4 Citations (Scopus)

    How mycobacteria take advantage of the weakness in human immune system in the modern world

    Chao, W. C., Yen, C. L., Wu, C. H. & Shieh, C. C., 2020 Apr, In : Journal of Microbiology, Immunology and Infection. 53, 2, p. 209-215 7 p.

    Research output: Contribution to journalReview article

    Open Access
  • Bidirectional relationship between systemic lupus erythematosus and non-Hodgkin's lymphoma: A nationwide population-based study

    Wang, L. H., Wang, W. M., Lin, S. H. & Shieh, C. C., 2019 Jul 1, In : Rheumatology (United Kingdom). 58, 7, p. 1245-1249 5 p.

    Research output: Contribution to journalArticle

  • 1 Citation (Scopus)

    Bronchoscopy-guided bronchial epithelium sampling as a tool for selecting the optimal biologic treatment in a patient with severe asthma: A case report

    Kuo, C. W., Liao, X. M., Huang, Y. C., Chang, H. Y. & Shieh, C. C., 2019 Nov 27, In : Allergy, Asthma and Clinical Immunology. 15, 1, 76.

    Research output: Contribution to journalArticle

    Open Access
  • Increased ILC3s associated with higher levels of IL‐1β aggravates inflammatory arthritis in mice lacking phagocytic NADPH oxidase

    Chan, T., Yen, C., Huang, Y., Lo, P., Nigrovic, P. A., Cheng, C., Wang, W., Wu, S. & Shieh, C-C., 2019 Jul 26, In : European Journal of Immunology.

    Research output: Contribution to journalArticle

    1 Citation (Scopus)


    Redox Regulation of Neutrophil Extracellular Traps Formation and IL-1β Processing in Serum-induced Arthritis

    Author: 正綱, 許., 2018 Jul 18

    Supervisor: Shieh, C. (Supervisor)

    Student thesis: Master's Thesis

    The immunopathogensis underlying the higher severity and mortality in dengue virus infection in diabetes mellitus

    Author: 松林, 劉., 2018 Aug 8

    Supervisor: Shieh, C. (Supervisor)

    Student thesis: Master's Thesis

    The Role of Leukocyte Signal Transduction on the Pathogenesis of Secondary Immunodeficiency in Obesity

    Author: 嘉良, 顏., 2014 Aug 15

    Supervisor: Shieh, C. (Supervisor)

    Student thesis: Doctoral Thesis