• 1613 Citations
  • 19 h-Index
1986 …2019
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Personal profile

Education

  • 1996 PhD. Institute of Immunolgy, Harvard University, USA

Experience

  • 1996.07~1997.01 Postdoctoral Research/Brigham and Women’s Hospital/Harvard University
  • 1997.02~Present Attending Physician/Divisionof Pediatric Allergy and Immunology/National Cheng Kung University Hospital
  • 1998.08~2002.07 Assistant Professor/Department of Microbiology and Immunology, NCKU
  • 2002.03~2004.07 Head of Pediatric Allergy and Immunology Division/National Cheng Kung University Hospital
  • 2002.08~2007.07 Associate Professor/Department of Microbiology and Immunology, NCKU
  • 2007.08~2010.07 Professor/Department of Microbiology and Immunology, NCKU
  • 2010.08~present Editor/ Journal of Microbiology, Immunology and Infection
  • 2011.08~2017.07 Professor Director/ Graduate institute of clinical medicine & clinical medicine researcher center, NCKU
  • 2011.08~Present Professor
  • 2016.08~ Distinguished Professor

Research Interests

The research in Prof. Chi-Chang Shieh’s laboratory focuses on the immune mechanisms underlying the tissue inflammation of human diseases including allergic asthma, immune mediated arthritis and autoimmune reactions in immunodeficiency diseases.

His recent laboratory research took advantage of the resources in the campuses of National Cheng Kung University and Southern Facility of National Laboratory Animal Center, both located in Tainan City, to elucidate the molecular and cellular mechanism leading to tissue inflammation in patients with low production of reactive oxygen species (ROS). Moreover, he devised methods aimed to correct the low production of ROS by leukocytes, which is the cause of the primary immunodeficiency disease chronic granulomatous disease (CGD), using state-of-the-art technologies and cutting-edge knowledge in leukocyte biology.

The main accomplishments of his research are concisely described as follows:

1. To establish a clinic of human primary immunodeficiency for diagnosis, treatment and research for this group of difficult diseases.

2. To develop the research for secondary immunodeficiency 3. To unravel the mechanisms underlying redox regulation of immune responses 4. Development of organelle-specific treatment for immunological diseases

Fingerprint Dive into the research topics where Chi-Chang Shieh is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 18 Similar Profiles
Taiwan Medicine & Life Sciences
Leukocytes Medicine & Life Sciences
Allergens Medicine & Life Sciences
Reactive Oxygen Species Medicine & Life Sciences
Chronic Granulomatous Disease Medicine & Life Sciences
Asthma Medicine & Life Sciences
Pulmonary Surfactant-Associated Protein D Medicine & Life Sciences
Cytokines Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2001 2018

Research Output 1986 2019

  • 1613 Citations
  • 19 h-Index
  • 73 Article
  • 3 Comment/debate
  • 2 Patent
  • 1 Review article
1 Citation (Scopus)

Bidirectional relationship between systemic lupus erythematosus and non-Hodgkin's lymphoma: A nationwide population-based study

Wang, L. H., Wang, W. M., Lin, S-H. & Shieh, C-C., 2019 Jul 1, In : Rheumatology (United Kingdom). 58, 7, p. 1245-1249 5 p.

Research output: Contribution to journalArticle

Systemic Lupus Erythematosus
Non-Hodgkin's Lymphoma
Population
Incidence
Taiwan

Increased ILC3s associated with higher levels of IL‐1β aggravates inflammatory arthritis in mice lacking phagocytic NADPH oxidase

Chan, T., Yen, C., Huang, Y., Lo, P., Nigrovic, P. A., Cheng, C., Wang, W., Wu, S. & Shieh, C-C., 2019 Jul 26, In : European Journal of Immunology.

Research output: Contribution to journalArticle

Targeted delivery of curcumin rescues endoplasmic reticulum-retained mutant Nox2 protein and avoids leukocyte apoptosis

Yen, C. L., Liao, Y. C., Chen, R. F., Huang, Y. F., Chung, W. C., Lo, P. C., Chang, C-F., Wu, P-C., Shieh, D-B., Jiang, S. T. & Shieh, C-C., 2019 Jun 15, In : Journal of Immunology. 202, 12, p. 3394-3403 10 p.

Research output: Contribution to journalArticle

Curcumin
Mutant Proteins
Endoplasmic Reticulum
Leukocytes
Apoptosis
1 Citation (Scopus)
Interleukin-7 Receptors
Exome
Severe Combined Immunodeficiency
Newborn Infant
Mutation
Peritoneal Dialysis
Peritonitis
Staphylococcus
Taiwan
Staphylococcal Infections

Thesis

Redox Regulation of Neutrophil Extracellular Traps Formation and IL-1β Processing in Serum-induced Arthritis

Author: 正綱, 許., 2018 Jul 18

Supervisor: Shieh, C. (Supervisor)

Student thesis: Master's Thesis

The immunopathogensis underlying the higher severity and mortality in dengue virus infection in diabetes mellitus

Author: 松林, 劉., 2018 Aug 8

Supervisor: Shieh, C. (Supervisor)

Student thesis: Master's Thesis

The Role of Leukocyte Signal Transduction on the Pathogenesis of Secondary Immunodeficiency in Obesity

Author: 嘉良, 顏., 2014 Aug 15

Supervisor: Shieh, C. (Supervisor)

Student thesis: Doctoral Thesis