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1986 …2023

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Personal profile


  • 1996 PhD. Institute of Immunolgy, Harvard University, USA


  • 1996.07~1997.01 Postdoctoral Research/Brigham and Women’s Hospital/Harvard University
  • 1997.02~Present Attending Physician/Divisionof Pediatric Allergy and Immunology/National Cheng Kung University Hospital
  • 1998.08~2002.07 Assistant Professor/Department of Microbiology and Immunology, NCKU
  • 2002.03~2004.07 Head of Pediatric Allergy and Immunology Division/National Cheng Kung University Hospital
  • 2002.08~2007.07 Associate Professor/Department of Microbiology and Immunology, NCKU
  • 2007.08~2010.07 Professor/Department of Microbiology and Immunology, NCKU
  • 2010.08~present Editor/ Journal of Microbiology, Immunology and Infection
  • 2011.08~2017.07 Professor Director/ Graduate institute of clinical medicine & clinical medicine researcher center, NCKU
  • 2011.08~Present Professor
  • 2016.08~ Distinguished Professor

Research Interests

The research in Prof. Chi-Chang Shieh’s laboratory focuses on the immune mechanisms underlying the tissue inflammation of human diseases including allergic asthma, immune mediated arthritis and autoimmune reactions in immunodeficiency diseases.

His recent laboratory research took advantage of the resources in the campuses of National Cheng Kung University and Southern Facility of National Laboratory Animal Center, both located in Tainan City, to elucidate the molecular and cellular mechanism leading to tissue inflammation in patients with low production of reactive oxygen species (ROS). Moreover, he devised methods aimed to correct the low production of ROS by leukocytes, which is the cause of the primary immunodeficiency disease chronic granulomatous disease (CGD), using state-of-the-art technologies and cutting-edge knowledge in leukocyte biology.

The main accomplishments of his research are concisely described as follows:

1. To establish a clinic of human primary immunodeficiency for diagnosis, treatment and research for this group of difficult diseases.

2. To develop the research for secondary immunodeficiency 3. To unravel the mechanisms underlying redox regulation of immune responses 4. Development of organelle-specific treatment for immunological diseases

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being


Dive into the research topics where Chi-Chang Shieh is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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