Chih-Hung Chen

Associate Professor

  • 1382 Citations
  • 22 h-Index
19972019
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Research Output 1997 2019

  • 1382 Citations
  • 22 h-Index
  • 72 Article
  • 5 Letter
  • 1 Conference contribution
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Article
1997
3 Citations (Scopus)

Apolipoprotein B gene polymorphisms in Taiwanese ischemic stroke patients

Chen, C-H., Lai, M. L., Lai, M-D. & Huang, J. D., 1997 Jul 1, In : Journal of the Formosan Medical Association. 96, 7, p. 499-502 4 p.

Research output: Contribution to journalArticle

Apolipoproteins B
Stroke
Restriction Fragment Length Polymorphisms
Genes
Alleles

Temporary protein C deficiency associated with cerebellar infarction: A case report

Chen, C-H., 1997, In : Acta Neurologica Taiwanica. 6, 4, p. 324-327 4 p.

Research output: Contribution to journalArticle

Protein C Deficiency
Protein C
Infarction
Dysarthria
Cerebral Infarction
1999
2 Citations (Scopus)

Nontraumatic intracerebral hemorrhage in young adults: Analysis of 214 cases

Chen, C. H. & Lai, M. L., 1999 Jan 1, In : Acta Neurologica Taiwanica. 8, 2, p. 96-101 6 p.

Research output: Contribution to journalArticle

Cerebral Hemorrhage
Young Adult
Hypertension
Taiwan
Arteriovenous Malformations
2000
5 Citations (Scopus)

Midbrain hemorrhage presenting with trochlear nerve palsy

Chen, C-H., Hwang, W. J., Tsai, T. & Lai, M. L., 2000 Feb 1, In : Chinese Medical Journal (Taipei). 63, 2, p. 138-143 6 p.

Research output: Contribution to journalArticle

Trochlear Nerve Diseases
Mesencephalon
Diplopia
Hemorrhage
Tinnitus
2001
2 Citations (Scopus)

A novel platelet-rich arterial thrombosis model in rabbits: Simple, reproducible, and dynamic real-time measurement by using double-opposing inverted-sutures model

Shieh, S-J., Chiu, H. Y., Shi, G. Y., Wu, C. M., Wang, J. C., Chen, C-H. & Wu, H-L., 2001 Sep 1, In : Thrombosis Research. 103, 5, p. 363-376 14 p.

Research output: Contribution to journalArticle

Sutures
Thrombosis
Blood Platelets
Rabbits
Fibrinolytic Agents
35 Citations (Scopus)

Functional mutation in the promoter region of thrombomodulin gene in relation to carotid atherosclerosis

Li, Y-H., Chen, C-H., Yeh, P. S., Lin, H. J., Chang, B. I., Lin, J. C., Guo, H-R., Wu, H-L., Shi, G. Y., Lai, M. L. & Chen, J. H., 2001 Feb 15, In : Atherosclerosis. 154, 3, p. 713-719 7 p.

Research output: Contribution to journalArticle

Thrombomodulin
Carotid Artery Diseases
Genetic Promoter Regions
Mutation
Genes
12 Citations (Scopus)

Recurrent hypertensive intracerebral hemorrhage among Taiwanese.

Chen, C-H., Huang, C-W., Chen, H. H. & Lai, M. L., 2001 Jan 1, In : The Kaohsiung journal of medical sciences. 17, 11, p. 556-563 8 p.

Research output: Contribution to journalArticle

Hypertensive Intracranial Hemorrhage
Hemorrhage
Recurrence
Pons
Caudate Nucleus
2002
8 Citations (Scopus)
tibolone
Hormone Replacement Therapy
Middle Cerebral Artery
Conjugated (USP) Estrogens
Medroxyprogesterone Acetate
2003
31 Citations (Scopus)

4G/5G promoter polymorphism of plasminogen activator inhibitor-1, lipid profiles, and ischemic stroke

Chen, C-H., Eng, H. L., Chang, C-J., Tsai, T., Lai, M. L., Chen, H. Y., Liu, C. J. & Lin, T. M., 2003 Aug 1, In : Journal of Laboratory and Clinical Medicine. 142, 2, p. 100-105 6 p.

Research output: Contribution to journalArticle

Plasminogen Activator Inhibitor 1
Polymorphism
Stroke
Lipids
Genotype
30 Citations (Scopus)

Association of CD14 promoter gene polymorphism and Chlamydia pneumoniae infection

Eng, H. L., Chen, C. H., Kuo, C. C., Wu, J. S., Wang, C. H. & Lin, T. M., 2003 Jul 1, In : Journal of Infectious Diseases. 188, 1, p. 90-97 8 p.

Research output: Contribution to journalArticle

Chlamydophila pneumoniae
Chlamydia Infections
Genotype
Genes
Monocytes
14 Citations (Scopus)
tibolone
Conjugated (USP) Estrogens
Medroxyprogesterone Acetate
Cognition
Aptitude
2004
33 Citations (Scopus)

A CD14 promoter polymorphism is associated with CD14 expression and Chlamydia-stimulated TNFα production

Eng, H. L., Wang, C. H., Chen, C. H., Chou, M. H., Cheng, C. T. & Lin, T. M., 2004 Aug 1, In : Genes and Immunity. 5, 5, p. 426-430 5 p.

Research output: Contribution to journalArticle

Chlamydia
Genotype
Pattern Recognition Receptors
Taiwan
Innate Immunity
67 Citations (Scopus)
Hepatocellular Carcinoma
Tumor Necrosis Factor-alpha
Alleles
Genes
Hepatitis C
25 Citations (Scopus)

Platelet glycoprotein Ia C807T, Ib C3550T, and IIIa Pl A1/A2 polymorphisms and ischemic stroke in young Taiwanese

Chen, C-H., Lo, Y. K., Ke, D., Liu, C. K., Liou, C. W., Wu, H-L. & Lai, M. L., 2004 Dec 15, In : Journal of the Neurological Sciences. 227, 1, p. 1-5 5 p.

Research output: Contribution to journalArticle

Integrin alpha2
Platelet Glycoprotein GPIb-IX Complex
varespladib methyl
Glycoproteins
Stroke
9 Citations (Scopus)

The homozygote AA genotype of the α 1-antichymotrypsin gene may confer protection against early-onset Parkinson's disease in women

Lin, J. J., Yueh, K. C., Chang, C. Y., Chen, C. H. & Lin, S. Z., 2004 Dec 1, In : Parkinsonism and Related Disorders. 10, 8, p. 469-473 5 p.

Research output: Contribution to journalArticle

Homozygote
Parkinson Disease
Genotype
Genes
Age of Onset
2005
32 Citations (Scopus)

Homozygous deletion genotype of angiotensin converting enzyme confers protection against migraine in man

Lin, J. J., Wang, P. J., Chen, C-H., Yueh, K. C., Lin, S. Z. & Harn, H. J., 2005 Sep 1, In : Acta Neurologica Taiwanica. 14, 3, p. 120-125 6 p.

Research output: Contribution to journalArticle

Peptidyl-Dipeptidase A
Migraine Disorders
Genotype
Homozygote
Genes
20 Citations (Scopus)

Ischemic neuroprotection with selective κ-opioid receptor agonist is gender specific

Chen, C. H., Toung, T. J. K., Hum, P. D., Koehler, R. C. & Bhardwaj, A., 2005 Jul 1, In : Stroke. 36, 7, p. 1557-1561 5 p.

Research output: Contribution to journalArticle

Opioid Receptors
Middle Cerebral Artery Infarction
Ischemia
Reperfusion
Neuroprotection
2006
22 Citations (Scopus)

A CD14 monocyte receptor polymorphism and genetic susceptibility to Parkinson's disease for females

Lin, J. J., Chen, C-H., Yueh, K. C., Chang, C. Y. & Lin, S. Z., 2006 Jan 1, In : Parkinsonism and Related Disorders. 12, 1, p. 9-13 5 p.

Research output: Contribution to journalArticle

Genetic Predisposition to Disease
Parkinson Disease
Monocytes
Genotype
Homozygote
40 Citations (Scopus)

Effect of duration of osmotherapy on blood-brain barrier disruption and regional cerebral edema after experimental stroke

Chen, C. H., Toung, T. J. K., Sapirstein, A. & Bhardwaj, A., 2006 Jun 19, In : Journal of Cerebral Blood Flow and Metabolism. 26, 7, p. 951-958 8 p.

Research output: Contribution to journalArticle

Brain Edema
Blood-Brain Barrier
Mannitol
Stroke
Osmolar Concentration
15 Citations (Scopus)
Genetic Promoter Regions
Single Nucleotide Polymorphism
Tumor Necrosis Factor-alpha
Genes
Alleles
27 Citations (Scopus)

Plasma arginine-vasopressin following experimental stroke: Effect of osmotherapy

Chang, Y., Chen, T. Y., Chen, C. H., Crain, B. J., Toung, T. J. K. & Bhardwaj, A., 2006 May 1, In : Journal of Applied Physiology. 100, 5, p. 1445-1451 7 p.

Research output: Contribution to journalArticle

Arginine Vasopressin
Stroke
Mannitol
Middle Cerebral Artery Infarction
Hypertonic Saline Solutions
2007
29 Citations (Scopus)

Effect of osmotherapy with hypertonic saline on regional cerebral edema following experimental stroke: A study utilizing magnetic resonance imaging

Chen, C-H., Xue, R., Zhang, J., Li, X., Mori, S. & Bhardwaj, A., 2007 Aug 1, In : Neurocritical Care. 7, 1, p. 92-100 9 p.

Research output: Contribution to journalArticle

Brain Edema
Aquaporin 4
Stroke
Magnetic Resonance Imaging
Water
24 Citations (Scopus)

Osmotherapy with hypertonic saline attenuates water content in brain and extracerebral organs

Toung, T. J. K., Chen, C. H., Lin, C. & Bhardwaj, A., 2007 Feb 1, In : Critical care medicine. 35, 2, p. 526-531 6 p.

Research output: Contribution to journalArticle

Water
Brain
Lung
Osmolar Concentration
Intravenous Infusions
2008
4 Citations (Scopus)
Ventriculostomy
Hydrocephalus
Infarction
Dizziness
Ataxia
8 Citations (Scopus)
Near infrared spectroscopy
Rats
Blood
Hemoglobin
Oxygen
12 Citations (Scopus)

Rhabdomyolysis and pancreatitis associated with coadministration of danazol 600 mg/d and lovastatin 40 mg/d

Hsieh, C. Y. & Chen, C-H., 2008 Jul 1, In : Clinical Therapeutics. 30, 7, p. 1330-1335 6 p.

Research output: Contribution to journalArticle

Danazol
Lovastatin
Rhabdomyolysis
Pancreatitis
Thrombocytopenia
8 Citations (Scopus)

The association of C (-260)→T polymorphism in CD14 promoter and Chlamydia pneumoniae infection in ischemic stroke patients

Lin, T. M., Chen, C-H., Wu, H-L., Wang, C. H., Chen, Y. L. & Eng, H. L., 2008 Oct 1, In : American Journal of Clinical Pathology. 130, 4, p. 595-601 7 p.

Research output: Contribution to journalArticle

Chlamydophila pneumoniae
Chlamydia Infections
Chaperonin 60
Stroke
Genotype
58 Citations (Scopus)

The perivascular pool of aquaporin-4 mediates the effect of osmotherapy in postischemic cerebral edema

Zeynalov, E., Chen, C. H., Froehner, S. C., Adams, M. E., Ottersen, O. P., Amiry-Moghaddam, M. & Bhardwaj, A., 2008 Sep, In : Critical care medicine. 36, 9, p. 2634-2640 7 p.

Research output: Contribution to journalArticle

Aquaporin 4
Brain Edema
Blood-Brain Barrier
Aquaporin 3
Stroke
2010
3 Citations (Scopus)

Acute aortic dissection mimicking basilar artery occlusion in a patient presenting with sudden coma

Sung, P-S., Fang, C. W. & Chen, C-H., 2010 Jul 1, In : Journal of Clinical Neuroscience. 17, 7, p. 952-953 2 p.

Research output: Contribution to journalArticle

Basilar Artery
Coma
Brain Stem
Dissection
Hospital Emergency Service
5 Citations (Scopus)

Comparative outcomes between hemo- and peritoneal dialysis patients with acute intracerebral hemorrhage

Hsieh, C. Y., Chen, C. H., Wu, A. B. & Tseng, C. C., 2010 Jul 1, In : American Journal of Nephrology. 32, 1, p. 31-37 7 p.

Research output: Contribution to journalArticle

Cerebral Hemorrhage
Peritoneal Dialysis
Chronic Kidney Failure
Renal Dialysis
Mortality
155 Citations (Scopus)

Get with the guidelines-stroke performance indicators: Surveillance of Stroke Care in the Taiwan Stroke Registry: Get with the guidelines-stroke in Taiwan

Hsieh, F. I., Lien, L. M., Chen, S. T., Bai, C. H., Sun, M. C., Tseng, H. P., Chen, Y. W., Chen, C. H., Jeng, J. S., Tsai, S. Y., Lin, H. J., Liu, C. H., Lo, Y. K., Chen, H. J., Chiu, H. C., Lai, M. L., Lin, R. T., Sun, M. H., Yip, B. S., Chiou, H. Y. & 1 others, Hsu, C. Y., 2010 Sep 14, In : Circulation. 122, 11, p. 1116-1123 8 p.

Research output: Contribution to journalArticle

Taiwan
Registries
Stroke
Guidelines
Quality of Health Care
3 Citations (Scopus)

Isolated brainstem involvement in a patient with hypertensive encephalopathy

Hsieh, C. Y., Chen, C-H. & Chang, T. P., 2010 Mar 1, In : Acta Neurologica Taiwanica. 19, 1, p. 45-50 6 p.

Research output: Contribution to journalArticle

Hypertensive Encephalopathy
Brain Stem
Brain Stem Infarctions
Emergencies
Blood Pressure
96 Citations (Scopus)

Outcomes of thrombolytic therapy for acute ischemic stroke in Chinese patients: The Taiwan thrombolytic therapy for acute ischemic stroke (TTT-AIS) study

Chao, A. C., Hsu, H. Y., Chung, C. P., Liu, C. H., Chen, C. H., Teng, M. M. H., Peng, G. S., Sheng, W. Y. & Hu, H. H., 2010 May 1, In : Stroke. 41, 5, p. 885-890 6 p.

Research output: Contribution to journalArticle

Thrombolytic Therapy
Taiwan
Tissue Plasminogen Activator
Stroke
Cerebral Hemorrhage
2011
17 Citations (Scopus)

Outcome of acute ischemic stroke in very elderly patients: Is intravenous thrombolysis beneficial?

Sung, P-S., Chen, C-H., Hsieh, H. C., Fang, C. W., Hsieh, C. Y., Sun, Y-T. & Hwang, W. J., 2011 Sep 1, In : European Neurology. 66, 2, p. 110-116 7 p.

Research output: Contribution to journalArticle

Tissue Plasminogen Activator
Stroke
Plasminogen Activators
Intracranial Hemorrhages
Brain Ischemia
2012
9 Citations (Scopus)

Ambient temperature and spontaneous intracerebral haemorrhage: A crosssectional analysis in Tainan, Taiwan

Fang, C. W., Ma, M. C., Lin, H. J. & Chen, C. H., 2012 Jul 16, In : BMJ open. 2, 3, e000842.

Research output: Contribution to journalArticle

Cerebral Hemorrhage
Taiwan
Temperature
Registries
Retrospective Studies
8 Citations (Scopus)

Epistasis Analysis for Estrogen Metabolic and Signaling Pathway Genes on Young Ischemic Stroke Patients

Hsieh, Y. C., Jeng, J. S., Lin, H. J., Hu, C. J., Yu, C. C., Lien, L. M., Peng, G. S., Chen, C. I. C. I., Tang, S. C., Chi, N. F., Tseng, H. P., Chern, C. M., Hsieh, F. I. F. I., Bai, C. H., Chen, Y. R., Chiou, H. Y., Yeh, S. J., Tsai, L. K., Kong, S., Chiu, H. C. & 52 others, Chen, W. H., Huang, T. H., Lau, C. I., Wu, Y. Y., Yuan, R. Y., Sheu, J. J., Yu, J. M., Ho, C. S., Chen, C. I., Sung, J. Y., Weng, H. Y., Han, Y. H., Huang, C. P., Chung, W. T., Ke, D. S., Chang, C. Y., Yeh, P. S., Lin, K. C., Cheng, T. J., Chou, C. H., Yang, C. M., Lin, J. C., Hsu, Y. D., Denq, J. C., Lee, J. T., Hsu, C. H., Lin, C. C., Yen, C. H., Cheng, C. A., Sung, Y. F., Chen, Y. L., Lien, M. T., Liu, C. C., Yang, F. C., Wu, Y. C., Tso, A. C., Lai, Y. H., Chiang, C. I., Tsai, C. K., Liu, M. T., Lin, Y. C., Hsu, Y. C., Chen, C. H., Sung, P. S., Hu, H. H., Wong, W. J., Luk, Y. O., Hsu, L. C., Chung, C. P., Liu, C. H., Lin, C. L. & Lin, H. C., 2012 Oct 24, In : PloS one. 7, 10, e47773.

Research output: Contribution to journalArticle

catechol O-methyltransferase
Guaiacol
epistasis
Transferases
Metabolic Networks and Pathways
24 Citations (Scopus)

Optimal dose for stroke thrombolysis in Asians: Low dose may have similar safety and efficacy as standard dose

Chen, C. H., Hsieh, C. Y., Lai, T. B., Chuang, M. T., Chen, W. L. & Sun, M. C., 2012 Jul 1, In : Journal of Thrombosis and Haemostasis. 10, 7, p. 1270-1275 6 p.

Research output: Contribution to journalArticle

Stroke
Safety
Cerebral Hemorrhage
Plasminogen Activators
Tissue Plasminogen Activator
2013
35 Citations (Scopus)

Comparison of risk-scoring systems in predicting symptomatic intracerebral hemorrhage after intravenous thrombolysis

Sung, S. F., Chen, S. C. C., Lin, H. J., Chen, Y. W., Tseng, M. C. & Chen, C-H., 2013 Jun 1, In : Stroke. 44, 6, p. 1561-1566 6 p.

Research output: Contribution to journalArticle

Cerebral Hemorrhage
Stroke
Hemorrhage
National Institutes of Health (U.S.)
Pressure
8 Citations (Scopus)
Program Development
Emergency Medical Services
Stroke
Triage
Linear Models
15 Citations (Scopus)
Thrombolytic Therapy
Taiwan
Stroke
Cerebral Hemorrhage
Hospital Mortality
9 Citations (Scopus)

Predicting symptomatic intracerebral hemorrhage after intravenous thrombolysis: Stroke territory as a potential pitfall

Sung, S. F., Chen, C-H., Chen, Y. W., Tseng, M. C., Shen, H. C. & Lin, H. J., 2013 Dec 15, In : Journal of the Neurological Sciences. 335, 1-2, p. 96-100 5 p.

Research output: Contribution to journalArticle

Cerebral Hemorrhage
Stroke
National Institute of Neurological Disorders and Stroke
Blood Vessels
Registries
2014
29 Citations (Scopus)

Different doses of recombinant tissue-type plasminogen activator for acute stroke in Chinese patients

Chao, A. C., Liu, C. K., Chen, C. H., Lin, H. J., Liu, C. H., Jeng, J. S., Hu, C. J., Chung, C. P., Hsu, H. Y., Sheng, W. Y. & Hu, H. H., 2014 Aug, In : Stroke. 45, 8, p. 2359-2365 7 p.

Research output: Contribution to journalArticle

Tissue Plasminogen Activator
Stroke
Cerebral Hemorrhage
Safety
Population
9 Citations (Scopus)

Efforts to reduce the door-to-needle time of thrombolysis in acute ischemic stroke: Video-assisted therapeutic risk communication

Hsieh, C. Y., Chen, W. F., Chen, C-H., Wang, C. Y., Chen, C. J., Lai, E. & Chen, T. S., 2014 Dec 1, In : Journal of the Formosan Medical Association. 113, 12, p. 929-933 5 p.

Research output: Contribution to journalArticle

Needles
Stroke
Communication
Tissue Plasminogen Activator
Therapeutics
12 Citations (Scopus)

Is renal dysfunction associated with adverse stroke outcome after thrombolytic therapy?

Hsieh, C. Y., Lin, H. J., Sung, S. F., Hsieh, H. C., Lai, E. C. C. & Chen, C. H., 2014 Jan 1, In : Cerebrovascular Diseases. 37, 1, p. 51-56 6 p.

Research output: Contribution to journalArticle

Thrombolytic Therapy
Stroke
Kidney
Cerebral Hemorrhage
Glomerular Filtration Rate
3 Citations (Scopus)

Oxfordshire community stroke project classification improves prediction of post-thrombolysis symptomatic intracerebral hemorrhage

Sung, S. F., Chen, S. C. C., Lin, H. J., Chen, C-H., Tseng, M. C., Wu, C. S., Hsu, Y. C., Hung, L. C. & Chen, Y. W., 2014 Mar 1, In : BMC Neurology. 14, 1, 39.

Research output: Contribution to journalArticle

Cerebral Hemorrhage
Stroke
Area Under Curve
Lacunar Stroke
ROC Curve
2015

Delayed Trigeminal Motor Denervation after Pontine Hemorrhage

Chao, L-C., Abbasali Tailor, A. R., Chen, C-H. & Lee, J-S., 2015 Sep 1, In : Journal of Stroke and Cerebrovascular Diseases. 24, 9, p. e261-e263

Research output: Contribution to journalArticle

Denervation
Hemorrhage
Masseter Muscle
Atrophy
Emergencies
51 Citations (Scopus)

Developing a stroke severity index based on administrative data was feasible using data mining techniques

Sung, S. F., Hsieh, C. Y., Kao, Y-H., Lin, H. J., Chen, C-H., Chen, Y. W. & Hu, Y. H., 2015 Nov 1, In : Journal of Clinical Epidemiology. 68, 11, p. 1292-1300 9 p.

Research output: Contribution to journalArticle

Data Mining
Stroke
Linear Models
National Institutes of Health (U.S.)
Registries
6 Citations (Scopus)
Multicenter Studies
Observational Studies
Stroke
Kidney
Multivariate Analysis
10 Citations (Scopus)

Low estimated glomerular filtration rate is associated with poor outcomes in patients who suffered a large artery atherosclerosis stroke

Yeh, S. J., Jeng, J. S., Tang, S. C., Liu, C. H., Hsu, S. P., Chen, C. H., Lien, L. M., Lin, H. J., Chen, C. M., Lin, R. T., Lee, S. P., Lin, C. H., Yeh, C. H., Sun, Y., Sun, M. H., Yin, J. H., Lin, C. C., Wen, C. P., Tsai, L. K., Sung, F. C. & 1 others, Hsu, C. Y., 2015 Apr 1, In : Atherosclerosis. 239, 2, p. 328-334 7 p.

Research output: Contribution to journalArticle

Glomerular Filtration Rate
Atherosclerosis
Arteries
Stroke
National Institutes of Health (U.S.)
5 Citations (Scopus)

Safety of intravenous thrombolysis for ischaemic stroke in Asian octogenarians and nonagenarians

Sun, M. C., Lai, T. B., Jeng, J. S., Sung, S. F., Sung, P. S., Tang, S. C., Chen, W. L. & Chen, C. H., 2015 Jan 1, In : Age and ageing. 44, 1, p. 158-161 4 p.

Research output: Contribution to journalArticle

Stroke
Safety
Cerebral Hemorrhage
Mortality
Outcome Assessment (Health Care)