• 1062 Citations
  • 16 h-Index
20042019
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Research Output 2004 2019

  • 1062 Citations
  • 16 h-Index
  • 95 Article
2019
1 Citation (Scopus)

Dopamine enhancement of dextrorphan-induced skin antinociception in response to needle pinpricks in rats

Li, Y. Y., Chiu, C. C., Wang, J. J., Chen, Y. W. & Hung, C. H., 2019 Aug, In : Pharmacological Reports. 71, 4, p. 732-737 6 p.

Research output: Contribution to journalArticle

Dextrorphan
Needles
Dopamine
Skin
Local Anesthetics
2 Citations (Scopus)

Fucoxanthin Protects against oxLDL-Induced Endothelial Damage via Activating the AMPK-Akt-CREB-PGC1α Pathway

Ou, H. C., Chou, W. C., Chu, P. M., Hsieh, P. L., Hung, C. H. & Tsai, K. L., 2019 May, In : Molecular Nutrition and Food Research. 63, 10, 1801353.

Research output: Contribution to journalArticle

AMP-activated protein kinase
Cyclic AMP Response Element-Binding Protein
AMP-Activated Protein Kinases
response elements
low density lipoprotein
3 Citations (Scopus)

Galectin-3 aggravates ox-LDL-induced endothelial dysfunction through LOX-1 mediated signaling pathway

Ou, H. C., Chou, W. C., Hung, C. H., Chu, P. M., Hsieh, P. L., Chan, S. H. & Tsai, K. L., 2019 Jul 1, In : Environmental Toxicology. 34, 7, p. 825-835 11 p.

Research output: Contribution to journalArticle

Lipoprotein Receptors
Galectin 3
Lipoproteins
NF-kappa B
antibody

Multimodal exercise ameliorates exercise responses and body composition in head and neck cancer patients receiving chemotherapy

Yen, C. J., Hung, C. H., Kao, C. L., Tsai, W. M., Chan, S. H., Cheng, H. C., Jheng, W. T., Lu, Y. J. & Tsai, K. L., 2019 Dec 1, In : Supportive Care in Cancer. 27, 12, p. 4687-4695 9 p.

Research output: Contribution to journalArticle

Head and Neck Neoplasms
Body Composition
Exercise
Drug Therapy
Heart Rate
1 Citation (Scopus)

Phentolamine Reverses Epinephrine-Enhanced Skin Antinociception of Dibucaine in Rats

Chou, A. K., Chiu, C. C., Chen, Y. W., Wang, J. J. & Hung, C. H., 2019 Jun 1, In : Anesthesia and analgesia. 128, 6, p. 1336-1343 8 p.

Research output: Contribution to journalArticle

Dibucaine
Phentolamine
Epinephrine
Skin
Bupivacaine
Open Access
Oxidative stress
p38 Mitogen-Activated Protein Kinases
Chondrocytes
Protein Kinases
Oxidative Stress

Pulse Oximetry Monitor Feasible for Early Screening of Obstructive Sleep Apnea (OSA)

Lin, H. C., Su, C. L., Ong, J. H., Tsai, K. L., Chen, Y. W., Lin, C. Y., Chiang, L. L. & Hung, C. H., 2019 Jan 1, In : Journal of Medical and Biological Engineering.

Research output: Contribution to journalArticle

Screening
Oxygen
Wear of materials
Sleep
2 Citations (Scopus)

Serotonin enhances oxybuprocaine- and proxymetacaine-induced cutaneous analgesia in rats

Chou, A. K., Chiu, C. C., Wang, J. J., Chen, Y. W. & Hung, C-H., 2019 Mar 5, In : European Journal of Pharmacology. 846, p. 73-78 6 p.

Research output: Contribution to journalArticle

benoxinate
Analgesia
Serotonin
Skin
Analgesics

Subcutaneous brompheniramine for cutaneous analgesia in rats

Chiu, C. C., Chen, J. Y., Chen, Y. W., Wang, J. J. & Hung, C. H., 2019 Oct 5, In : European Journal of Pharmacology. 860, 172544.

Research output: Contribution to journalArticle

Brompheniramine
Mepivacaine
Analgesia
Skin
Local Anesthetics
Obstructive Sleep Apnea
Muscles
Apnea
Vital Capacity
Therapeutics

Ultrasound therapy reduces persistent post-thoracotomy tactile allodynia and spinal substance P expression in rats

Lin, H. T., Chiu, C. C., Liu, C. C., Chen, Y. W., Wang, J. J. & Hung, C-H., 2019 May 1, In : Regional anesthesia and pain medicine. 44, 5, p. 604-608 5 p.

Research output: Contribution to journalArticle

Hyperalgesia
Thoracotomy
Substance P
Interleukin-1beta
Therapeutics
2018
2 Citations (Scopus)

Adding dopamine to proxymetacaine or oxybuprocaine solutions potentiates and prolongs the cutaneous antinociception in rats

Chen, Y. W., Chiu, C. C., Lin, H. T., Wang, J. J. & Hung, C-H., 2018 May 1, In : Anesthesia and Analgesia. 126, 5, p. 1721-1728 8 p.

Research output: Contribution to journalArticle

benoxinate
Dopamine
Skin
proxymetacaine
11 Citations (Scopus)

Chlorogenic Acid Protects Against oxLDL-Induced Oxidative Damage and Mitochondrial Dysfunction by Modulating SIRT1 in Endothelial Cells

Tsai, K-L., Hung, C-H., Chan, S-H., Hsieh, P. L., Ou, H. C., Cheng, Y. H. & Chu, P. M., 2018 Jun 1, In : Molecular Nutrition and Food Research. 62, 11, 1700928.

Research output: Contribution to journalArticle

Chlorogenic Acid
chlorogenic acid
endothelial cells
Endothelial Cells
AMP-Activated Protein Kinases
9 Citations (Scopus)

Exercise intervention attenuates hyperhomocysteinemia-induced aortic endothelial oxidative injury by regulating SIRT1 through mitigating NADPH oxidase/LOX-1 signaling

Chan, S-H., Hung, C-H., Shih, J. Y., Chu, P. M., Cheng, Y. H., Lin, H. C., Hsieh, P. L. & Tsai, K-L., 2018 Apr 1, In : Redox Biology. 14, p. 116-125 10 p.

Research output: Contribution to journalArticle

Sirtuin 1
Hyperhomocysteinemia
NADPH Oxidase
Endothelium
Wounds and Injuries
9 Citations (Scopus)

Homocysteine causes dysfunction of chondrocytes and oxidative stress through repression of SIRT1/AMPK pathway: A possible link between hyperhomocysteinemia and osteoarthritis

Ma, C. H., Chiu, Y. C., Wu, C. H., Jou, I. M., Tu, Y. K., Hung, C-H., Hsieh, P. L. & Tsai, K-L., 2018 May 1, In : Redox Biology. 15, p. 504-512 9 p.

Research output: Contribution to journalArticle

Sirtuin 1
Hyperhomocysteinemia
AMP-Activated Protein Kinases
Oxidative stress
Homocysteine
2 Citations (Scopus)

Intrathecal pramoxine causes long-lasting spinal sensory and motor block in rats

Chou, A. K., Chiu, C. C., Han, M. M., Chen, Y. W., Wang, J. J. & Hung, C-H., 2018 Apr 1, In : Journal of Pharmacy and Pharmacology. 70, 4, p. 543-549 7 p.

Research output: Contribution to journalArticle

Bupivacaine
Proprioception
Spinal Injections
Nociception
Local Anesthetics
1 Citation (Scopus)

Local Application of Ultrasound Attenuates Neuropathic Allodynia and Proinflammatory Cytokines in Rats after Thoracotomy

Hung, C-H., Chiu, C. C., Liu, C. C. & Chen, Y. W., 2018 Feb 1, In : Regional anesthesia and pain medicine. 43, 2, p. 193-199 7 p.

Research output: Contribution to journalArticle

Hyperalgesia
Thoracotomy
Ribs
Cytokines
Therapeutics
1 Citation (Scopus)

Neural mobilization attenuates mechanical allodynia and decreases proinflammatory cytokine concentrations in rats with painful diabetic neuropathy

Zhu, G. C., Tsai, K-L., Chen, Y. W. & Hung, C-H., 2018 Apr 1, In : Physical Therapy. 98, 4, p. 214-222 9 p.

Research output: Contribution to journalArticle

Diabetic Neuropathies
Hyperalgesia
Cytokines
Sciatic Nerve
Interleukin-1
14 Citations (Scopus)

PKR activation causes inflammation and MMP-13 secretion in human degenerated articular chondrocytes

Ma, C. H., Wu, C. H., Jou, I. M., Tu, Y. K., Hung, C-H., Hsieh, P. L. & Tsai, K-L., 2018 Apr 1, In : Redox Biology. 14, p. 72-81 10 p.

Research output: Contribution to journalArticle

Chondrocytes
Matrix Metalloproteinases
Osteoarthritis
Joints
Chemical activation

Skin nociceptive block with pramoxine delivery by subcutaneous injection in rats

Chou, A. K., Chiu, C. C., Chen, Y. W., Wang, J. J. & Hung, C-H., 2018 Dec 1, In : Pharmacological Reports. 70, 6, p. 1180-1184 5 p.

Research output: Contribution to journalArticle

Subcutaneous Injections
Skin
Lidocaine
Local Anesthetics
pramoxine
1 Citation (Scopus)

Spinal sensory and motor blockade by intrathecal doxylamine and triprolidine in rats

Tzeng, J. I., Chiu, C. C., Wang, J. J., Hung, C-H. & Chen, Y. W., 2018 Dec 1, In : Journal of Pharmacy and Pharmacology. 70, 12, p. 1654-1661 8 p.

Research output: Contribution to journalArticle

Doxylamine
Triprolidine
Mepivacaine
Nociception
Spinal Anesthesia
1 Citation (Scopus)

Subcutaneous infiltration of doxylamine on cutaneous analgesia in rats

Hung, C-H., Shieh, J. P., Chiu, C. C., Wang, J. J. & Chen, Y. W., 2018 Jun 1, In : Pharmacological Reports. 70, 3, p. 565-569 5 p.

Research output: Contribution to journalArticle

Doxylamine
Bupivacaine
Analgesia
Skin
Analgesics
2017
3 Citations (Scopus)

2-Adamantanamine produces prolonged spinal block in rats

Chen, Y. W., Chen, C. M., Liu, K. S., Wang, J. J. & Hung, C-H., 2017 Jul 13, In : Neuroscience Letters. 653, p. 168-172 5 p.

Research output: Contribution to journalArticle

Mepivacaine
Local Anesthetics
Spinal Anesthesia
Anesthetics
8 Citations (Scopus)

Chicoric acid is a potent anti-atherosclerotic ingredient by antioxidant action and anti-inflammation capacity

Tsai, K. L., Kao, C. L., Hung, C. H., Cheng, Y. H., Lin, H. C. & Chu, P. M., 2017 Jan 1, In : Oncotarget. 8, 18, p. 29600-29612 13 p.

Research output: Contribution to journalArticle

Antioxidants
Inflammation
Endothelial Cells
DNA Breaks
Nitric Oxide Synthase Type III
6 Citations (Scopus)

Exercise combined with ultrasound attenuates neuropathic pain in rats associated with downregulation of IL-6 and TNF-α, but with upregulation of IL-10

Huang, P. C., Tsai, K. L., Chen, Y. W., Lin, H. T. & Hung, C. H., 2017 Jun 1, In : Anesthesia and analgesia. 124, 6, p. 2038-2044 7 p.

Research output: Contribution to journalArticle

Neuralgia
Interleukin-10
Interleukin-6
Up-Regulation
Down-Regulation
4 Citations (Scopus)
Peripheral Nerve Injuries
Sciatic Nerve
Constriction
Hypersensitivity
Anti-Inflammatory Agents
8 Citations (Scopus)

Isobolographic analysis of the cutaneous antinociceptive interaction between bupivacaine co-injected with serotonin in rats

Tzeng, J. I., Chiu, C. C., Wang, J. J., Chen, Y. W. & Hung, C-H., 2017 Oct 1, In : Pharmacological Reports. 69, 5, p. 846-850 5 p.

Research output: Contribution to journalArticle

Bupivacaine
Serotonin
Skin
Local Anesthetics
Reflex
4 Citations (Scopus)

Mexiletine co-injected with clonidine increases the quality and duration of cutaneous analgesia in response to skin pinpricks in the rat

Han, M. M., Chiu, C. C., Wang, J. J., Chen, Y. W. & Hung, C-H., 2017 Jul 27, In : Neuroscience Letters. 654, p. 23-27 5 p.

Research output: Contribution to journalArticle

Mexiletine
Clonidine
Analgesia
Skin
Analgesics
4 Citations (Scopus)

Naloxone prolongs cutaneous nociceptive block by lidocaine in rats

Chen, Y. W., Shieh, J. P., Liu, K. S., Wang, J. J. & Hung, C-H., 2017 Dec 1, In : Fundamental and Clinical Pharmacology. 31, 6, p. 636-642 7 p.

Research output: Contribution to journalArticle

Naloxone
Lidocaine
Skin
Analgesia
Local Anesthetics
16 Citations (Scopus)

SIRT1 inhibition causes oxidative stress and inflammation in patients with coronary artery disease

Chan, S-H., Hung, C-H., Shih, J. Y., Chu, P. M., Cheng, Y. H., Lin, H. C. & Tsai, K-L., 2017 Oct 1, In : Redox Biology. 13, p. 301-309 9 p.

Research output: Contribution to journalArticle

Sirtuin 1
Oxidative stress
Coronary Artery Disease
Oxidative Stress
Inflammation
9 Citations (Scopus)

Synergistic effects of serotonin or dopamine combined with lidocaine at producing nociceptive block in rats

Hung, C-H., Chiu, C. C., Liu, K. S., Chen, Y. W. & Wang, J. J., 2017 Jan 1, In : Regional anesthesia and pain medicine. 42, 3, p. 351-356 6 p.

Research output: Contribution to journalArticle

Lidocaine
Dopamine
Serotonin
Skin
Analgesia
2016
4 Citations (Scopus)

Baicalein is an available anti-atherosclerotic compound through modulation of nitric oxide-related mechanism under oxLDL exposure

Chan, S. H., Hung, C. H., Shih, J. Y., Chu, P. M., Cheng, Y. H., Tsai, Y. J., Lin, H. C. & Tsai, K. L., 2016 Jan 1, In : Oncotarget. 7, 28, p. 42881-42891 11 p.

Research output: Contribution to journalArticle

Nitric Oxide
Oxidants
Caspase 3
Reactive Oxygen Species
Oxidative Stress
13 Citations (Scopus)

Baicalein protects against oxLDL-caused oxidative stress and inflammation by modulation of AMPK- alpha

Tsai, K. L., Hung, C. H., Chan, S. H., Shih, J. Y., Cheng, Y. H., Tsai, Y. J., Lin, H. C. & Chu, P. M., 2016 Jan 1, In : Oncotarget. 7, 45, p. 72458-72468 11 p.

Research output: Contribution to journalArticle

AMP-Activated Protein Kinases
Oxidative Stress
Inflammation
Endothelial Cells
Vasodilation
7 Citations (Scopus)

Clonidine as an adjuvant for propranolol enhances its effect on infiltrative cutaneous analgesia in rats

Hung, C-H., Chiu, C. C., Liu, K. S., Wang, J. J. & Chen, Y. W., 2016 Mar 11, In : Neuroscience Letters. 616, p. 70-74 5 p.

Research output: Contribution to journalArticle

Clonidine
Propranolol
Analgesia
Bupivacaine
Skin
9 Citations (Scopus)

Cutaneous synergistic analgesia of bupivacaine in combination with dopamine in rats

Tzeng, J. I., Wang, J. N., Wang, J. J., Chen, Y. W. & Hung, C. H., 2016 May 4, In : Neuroscience Letters. 620, p. 88-92 5 p.

Research output: Contribution to journalArticle

Bupivacaine
Analgesia
Dopamine
Skin
Analgesics
7 Citations (Scopus)

Ifenprodil for prolonged spinal blockades of motor function and nociception in rats

Chen, Y. W., Chiu, C. C., Wang, J. N., Hung, C. H. & Wang, J. J., 2016 Apr 1, In : Pharmacological Reports. 68, 2, p. 357-362 6 p.

Research output: Contribution to journalArticle

Nociception
Bupivacaine
Local Anesthetics
Anesthetics
ifenprodil
7 Citations (Scopus)

Intrathecal amantadine for prolonged spinal blockade of sensory and motor functions in rats

Tzeng, J. I., Kan, C-D., Wang, J-N., Wang, J. J., Lin, H. T. & Hung, C-H., 2016 Aug 1, In : Fundamental and Clinical Pharmacology. 30, 4, p. 357-363 7 p.

Research output: Contribution to journalArticle

Amantadine
Mepivacaine
Spinal Anesthesia
Local Anesthetics
Proprioception
5 Citations (Scopus)

Intrathecal rimantadine induces motor, proprioceptive, and nociceptive blockades in rats

Tzeng, J. I., Wang, J. N., Wang, J. J., Chen, Y. W. & Hung, C. H., 2016 Apr 8, In : Neuroscience Letters. 618, p. 94-98 5 p.

Research output: Contribution to journalArticle

Rimantadine
Lidocaine
Spinal Anesthesia
Local Anesthetics
Anesthetics
11 Citations (Scopus)

Metformin regulates oxLDL-facilitated endothelial dysfunction by modulation of SIRT1 through repressing LOX-1-modulated oxidative signaling

Hung, C. H., Chan, S. H., Chu, P. M., Lin, H. C. & Tsai, K. L., 2016 Jan 1, In : Oncotarget. 7, 10, p. 10773-10787 15 p.

Research output: Contribution to journalArticle

Metformin
AMP-Activated Protein Kinases
Human Umbilical Vein Endothelial Cells
Wounds and Injuries
Oxidative Stress
4 Citations (Scopus)

Oleic acid activates MMPs up-regulation through SIRT1/PPAR-γ inhibition: A probable linkage between obesity and coronary arterial disease

Chan, S-H., Chu, P. M., Kao, C. L., Cheng, Y. H., Hung, C-H. & Tsai, K-L., 2016 Oct 1, In : Journal of biochemistry. 160, 4, p. 217-225 9 p.

Research output: Contribution to journalArticle

Sirtuin 1
Peroxisome Proliferator-Activated Receptors
Oleic Acid
Matrix Metalloproteinases
Coronary Disease
6 Citations (Scopus)

The addition of epinephrine to proxymetacaine or oxybuprocaine solution increases the depth and duration of cutaneous analgesia in rats

Chen, Y. W., Chiu, C. C., Kan, C. D., Wang, J. J. & Hung, C. H., 2016 Aug 23, In : Regional anesthesia and pain medicine. 41, 5, p. 601-606 6 p.

Research output: Contribution to journalArticle

benoxinate
Analgesia
Epinephrine
Lidocaine
Skin
2 Citations (Scopus)

The potential role of epigenetic modulations in BPPV maneuver exercises

Tsai, K. L., Wang, C. T., Kuo, C. H., Cheng, Y. Y., Ma, H. I., Hung, C. H., Tsai, Y. J. & Kao, C. L., 2016 Jan 1, In : Oncotarget. 7, 24, p. 35522-35534 13 p.

Research output: Contribution to journalArticle

Epigenomics
Exercise
Sirtuin 1
Benign Paroxysmal Positional Vertigo
Peroxisome Proliferator-Activated Receptors
4 Citations (Scopus)

Therapeutic ultrasound and treadmill training suppress peripheral nerve injury–induced pain in rats

Hung, C. H., Huang, P. C., Tzeng, J. I., Wang, J. J. & Chen, Y. W., 2016 Oct, In : Physical therapy. 96, 10, p. 1545-1553 9 p.

Research output: Contribution to journalArticle

Neuralgia
Peripheral Nerves
Constriction
Interleukin-6
Therapeutics
2015
12 Citations (Scopus)

Chlorpheniramine produces spinal motor, proprioceptive and nociceptive blockades in rats

Tzeng, J. I., Lin, H. T., Chen, Y. W., Hung, C. H. & Wang, J. J., 2015 Apr 5, In : European Journal of Pharmacology. 752, p. 55-60 6 p.

Research output: Contribution to journalArticle

Mepivacaine
Chlorpheniramine
Spinal Anesthesia
Proprioception
Nociception
10 Citations (Scopus)

Clonidine intensifies memantine cutaneous analgesia in response to local skin noxious pinprick in the rat

Wu, B. T., Chen, K. T., Liu, K. S., Chen, Y. W., Hung, C-H. & Wang, J. J., 2015 Jan 1, In : Pharmacological Reports. 67, 3, p. 485-489 5 p.

Research output: Contribution to journalArticle

Memantine
Clonidine
Analgesia
Lidocaine
Skin
10 Citations (Scopus)
docetaxel
Protein Kinase C beta
Oxidative stress
Oxidative Stress
Modulation
3 Citations (Scopus)

High frequency transcutaneous electrical nerve stimulation with diphenidol administration results in an additive antiallodynic effect in rats following chronic constriction injury

Lin, H. T., Chiu, C. C., Wang, J. J., Hung, C-H. & Chen, Y. W., 2015 Mar 4, In : Neuroscience Letters. 589, p. 62-66 5 p.

Research output: Contribution to journalArticle

Transcutaneous Electric Nerve Stimulation
Constriction
Wounds and Injuries
Tumor Necrosis Factor-alpha
Hyperalgesia
16 Citations (Scopus)
Sirtuin 1
Hyperhomocysteinemia
Homocysteine
Protein Kinase C
Methionine
6 Citations (Scopus)

Memantine elicits spinal blockades of motor function, proprioception, and nociception in rats

Chen, Y. W., Chiu, C. C., Liu, K. S., Hung, C. H. & Wang, J. J., 2015 Dec 1, In : Fundamental and Clinical Pharmacology. 29, 6, p. 567-574 8 p.

Research output: Contribution to journalArticle

Memantine
Proprioception
Nociception
Lidocaine
Spinal Anesthesia
9 Citations (Scopus)

Propranolol combined with dopamine has a synergistic action in intensifying and prolonging cutaneous analgesia in rats

Chen, Y. W., Chiu, C. C., Wei, Y. L., Hung, C-H. & Wang, J. J., 2015 Dec 1, In : Pharmacological Reports. 67, 6, p. 1224-1229 6 p.

Research output: Contribution to journalArticle

Propranolol
Analgesia
Dopamine
Skin
Analgesics