Chun-Hei Cheung

Associate Professor

  • 3012 Citations
  • 20 h-Index
20092019
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Research Output 2009 2019

  • 3012 Citations
  • 20 h-Index
  • 27 Article
  • 9 Review article
  • 3 Comment/debate
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Article
2019

Aging-induced Akt activation involves in aging-related pathologies and Aβ-induced toxicity

Chen, Y. R., Li, Y. H., Hsieh, T. C., Wang, C. M., Cheng, K. C., Wang, L., Lin, T. Y., Cheung, C-H., Wu, C. L. & Chinag, H., 2019 Aug 1, In : Aging Cell. 18, 4, e12989.

Research output: Contribution to journalArticle

Open Access
Alzheimer Disease
Pathology
Diptera
Behavioral Genetics
Amyloid Precursor Protein Secretases

Cloning, expression, and purification of the recombinant pro-apoptotic dominant-negative survivin T34A-C84A protein in Escherichia coli

Tsai, S. L., Chang, Y. C., Sarvagalla, S., Wang, S., Coumar, M. S. & Cheung, C-H., 2019 Aug 1, In : Protein Expression and Purification. 160, p. 73-83 11 p.

Research output: Contribution to journalArticle

Escherichia coli Proteins
Organism Cloning
Recombinant Proteins
Histidine
Proteins
2018
2 Citations (Scopus)

Dysfunction of different cellular degradation pathways contributes to specific β-amyloid42-induced pathologies

Ji, X. R., Cheng, K. C., Chen, Y. R., Lin, T. Y., Cheung, C-H., Wu, C. L. & Chinag, H., 2018 Mar 1, In : FASEB Journal. 32, 3, p. 1375-1387 13 p.

Research output: Contribution to journalArticle

Autophagy
Pathology
Proteasome Endopeptidase Complex
Ubiquitin
Alzheimer Disease
2017
4 Citations (Scopus)

HDAC2 and HDAC5 up-regulations modulate survivin and miR-125a-5p expressions and promote hormone therapy resistance in estrogen receptor positive breast cancer cells

Huang, W. T., Tsai, Y. H., Chen, S. H., Kuo, C. W., Kuo, Y-L., Lee, K-T., Chen, W. C., Wu, P. C., Chuang, C. Y., Cheng, S. M., Lin, C. H., Leung, E. Y., Chang, Y. C. & Cheung, C-H., 2017 Dec 13, In : Frontiers in Pharmacology. 8, DEC, 902.

Research output: Contribution to journalArticle

Estrogen Receptors
Up-Regulation
Hormones
Breast Neoplasms
Tamoxifen
1 Citation (Scopus)

Topical ophthalmic formulation of trichostatin A and SurR9-C84A for quick recovery post-alkali burn of corneal haze

Roy, K., Cheung, C-H., Kanwar, R. K., Sandhir, R. & Kanwar, J. R., 2017 May 5, In : Frontiers in Pharmacology. 8, MAY, 223.

Research output: Contribution to journalArticle

trichostatin A
Alkalies
Cornea
Conjunctiva
Wound Healing
2016
3 Citations (Scopus)

Delivery of a survivin Promoter-Driven antisense Survivin-Expressing plasmid DNA as a cancer therapeutic: A proof-of-concept study

Lin, K. Y., Cheng, S. M., Tsai, S. L., Tsai, J. Y., Lin, C. H. & Cheung, C-H., 2016 May 3, In : OncoTargets and Therapy. 9, p. 2601-2613 13 p.

Research output: Contribution to journalArticle

Plasmids
DNA
Neoplasms
Caspases
Therapeutics
11 Citations (Scopus)

Disruption of protein-protein interactions: Hot spot detection, structure-based virtual screening and: In vitro testing for the anti-cancer drug target-survivin

Sarvagalla, S., Cheung, C. H. A., Tsai, J. Y., Hsieh, H. P. & Coumar, M. S., 2016 Jan 1, In : RSC Advances. 6, 38, p. 31947-31959 13 p.

Research output: Contribution to journalArticle

Screening
Proteins
Testing
Pharmaceutical Preparations
Indinavir
3 Citations (Scopus)

E-Cadherin Aptamer-Conjugated Delivery of Doxorubicin for Targeted Inhibition of Prostate Cancer Cells

Chaudhary, R., Roy, K., Kanwar, R. K., Veedu, R. N., Krishnakumar, S., Cheung, C-H., Verma, A. K. & Kanwar, J. R., 2016 Jan 1, In : Australian Journal of Chemistry. 69, 10, p. 1108-1116 9 p.

Research output: Contribution to journalArticle

Cadherins
Doxorubicin
Cells
Chitosan
Cytotoxicity
20 Citations (Scopus)

Inhibition of HDAC3- and HDAC6-promoted survivin expression plays an important role in SAHA-induced autophagy and viability reduction in breast cancer cells

Lee, J. Y. C., Kuo, C. W., Tsai, S. L., Cheng, S. M., Chen, S. H., Chan, H. H., Lin, C. H., Lin, K. Y., Li, C. F., Kanwar, J. R., Leung, E. Y., Cheung, C. C. H., Huang, W. J., Wang, Y. C. & Cheung, C. H. A., 2016 Mar 31, In : Frontiers in Pharmacology. 7, MAR, 81.

Research output: Contribution to journalArticle

Autophagy
Breast Neoplasms
Protein Stability
Acetylation
Protein Isoforms
2015
13 Citations (Scopus)

Competitive inhibition of survivin using a cell-permeable recombinant protein induces cancer-specific apoptosis in colon cancer model

Roy, K., Kanwar, R. K., Krishnakumar, S., Cheung, C-H. & Kanwar, J. R., 2015 Feb 2, In : International journal of nanomedicine. 10, p. 1019-1043 25 p.

Research output: Contribution to journalArticle

Recombinant proteins
Cell death
Recombinant Proteins
Colonic Neoplasms
Tumors
14 Citations (Scopus)

Locked nucleic acid modified bi-specific aptamer-targeted nanoparticles carrying survivin antagonist towards effective colon cancer therapy

Roy, K., Kanwar, R. K., Cheung, C-H., Lee Fleming, C., Veedu, R. N., Krishnakumar, S. & Kanwar, J. R., 2015 Jan 1, In : RSC Advances. 5, 37, p. 29008-29016 9 p.

Research output: Contribution to journalArticle

Nucleic acids
Tumors
Nanoparticles
Chitosan
Nutrition
11 Citations (Scopus)

O6-methylguanine DNA methyltransferase repairs platinum-DNA adducts following cisplatin treatment and predicts prognoses of nasopharyngeal carcinoma

Chen, S. H., Kuo, C. C., Li, C. F., Cheung, C-H., Tsou, T. C., Chiang, H. C., Yang, Y. N., Chang, S. L., Lin, L. C., Pan, H. Y., Chang, K. Y. & Chang, J-Y., 2015 Sep 1, In : International Journal of Cancer. 137, 6, p. 1291-1305 15 p.

Research output: Contribution to journalArticle

Methyltransferases
Platinum
DNA Repair
DNA
Protein Methyltransferases
38 Citations (Scopus)

YM155 down-regulates survivin and XIAP, modulates autophagy and induces autophagy-dependent DNA damage in breast cancer cells

Cheng, S. M., Chang, Y. C., Liu, C. Y., Lee, J. Y. C., Chan, H. H., Kuo, C. W., Lin, K. Y., Tsai, S. L., Chen, S. H., Li, C. F., Leung, E., Kanwar, J. R., Huang, C. C., Chang, J-Y. & Cheung, C-H., 2015 Jan 1, In : British Journal of Pharmacology. 172, 1, p. 214-234 21 p.

Research output: Contribution to journalArticle

Autophagy
DNA Damage
Down-Regulation
Breast Neoplasms
Tamoxifen
2014
13 Citations (Scopus)

The inducible nitric-oxide synthase (iNOS)/Src axis mediates toll-like receptor 3 tyrosine 759 phosphorylation and enhances its signal transduction, leading to interferon- β synthesis in macrophages

Hsieh, M. Y., Chang, M. Y., Chen, Y. J., Li, Y. K., Chuang, T. H., Yu, G. Y., Cheung, C-H., Chen, H. C., Maa, M. C. & Leu, T-H., 2014 Mar 30, In : Journal of Biological Chemistry. 289, 13, p. 9208-9220 13 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 3
Signal transduction
Phosphorylation
Macrophages
Nitric Oxide Synthase Type II
2013
34 Citations (Scopus)
cathepsin S
Xanthine Oxidase
Autophagy
Cell death
DNA Damage
2012
31 Citations (Scopus)

Modulating the interaction of CXCR4 and CXCL12 by low-molecular-weight heparin inhibits hepatic metastasis of colon cancer

Ma, L., Qiao, H., He, C., Yang, Q., Cheung, C-H., Kanwar, J. R. & Sun, X., 2012 Apr 1, In : Investigational New Drugs. 30, 2, p. 508-517 10 p.

Research output: Contribution to journalArticle

Low Molecular Weight Heparin
Colonic Neoplasms
Neoplasm Metastasis
Liver
HCT116 Cells
40 Citations (Scopus)

Targeting cathepsin S induces tumor cell autophagy via the EGFR-ERK signaling pathway

Chen, K. L., Chang, W. S. W., Cheung, C-H., Lin, C. C., Huang, C. C., Yang, Y. N., Kuo, C. P., Kuo, C. C., Chang, Y. H., Liu, K. J., Wu, C. M. & Chang, J-Y., 2012 Apr 1, In : Cancer Letters. 317, 1, p. 89-98 10 p.

Research output: Contribution to journalArticle

cathepsin S
MAP Kinase Signaling System
Autophagy
Neoplasms
Apoptosis
2011
13 Citations (Scopus)

BPR1K653, a novel aurora kinase inhibitor, exhibits potent anti-proliferative activity in MDR1 (P-gp170)-mediated multidrug-resistant cancer cells

Cheung, C-H., Lin, W. H., HsuJohn, J. T. A., Hour, T. C., Yeh, T. K., Ko, S., Lien, T. W., Coumar, M. S., Liu, J. F., Lai, W. Y., Shiao, H. Y., Lee, T. R., Hsieh, H. P. & Chang, J-Y., 2011 Aug 24, In : PloS one. 6, 8, e23485.

Research output: Contribution to journalArticle

Aurora Kinases
phosphotransferases (kinases)
Cells
neoplasms
Neoplasms
5 Citations (Scopus)

Enhancement of non-homologous end joining DNA repair capacity confers cancer cells resistance to the novel selenophene compound, D-501036

Yang, Y. N., Chou, K. M., Pan, W. Y., Chen, Y. W., Tsou, T. C., Yeh, S. C., Cheung, C-H., Chen, L. T. & Chang, J-Y., 2011 Oct 1, In : Cancer Letters. 309, 1, p. 110-118 9 p.

Research output: Contribution to journalArticle

DNA Repair
Drug Resistance
DNA
KB Cells
Neoplasms
44 Citations (Scopus)

Investigations of survivin: The past, present and future

Cheung, C-H., Cheng, L. T., Chang, K. Y., Chen, H. H. & Chang, J-Y., 2011 Jan 1, In : Frontiers in Bioscience. 16, 3, p. 952-961 10 p.

Research output: Contribution to journalArticle

Cells
Neoplasms
Aurora Kinase B
Oncology
Chemotherapy
2010
33 Citations (Scopus)

A cell-permeable dominant-negative survivin protein induces apoptosis and sensitizes prostate cancer cells to TNF-α therapy

Cheung, C-H., Sun, X., Kanwar, J. R., Bai, J. Z., Cheng, L. T. & Krissansen, G. W., 2010 Oct 1, In : Cancer Cell International. 10, 36.

Research output: Contribution to journalArticle

Prostatic Neoplasms
Apoptosis
Neoplasms
Proteins
Uterine Cervical Neoplasms
24 Citations (Scopus)

Cancer cells acquire mitotic drug resistance properties through beta i-tubulin mutations and alterations in the expression of beta-tubulin isotypes

Cheung, C-H., Wu, S. Y., Lee, T. R., Chang, C. Y., Wu, J. S., Hsieh, H. P. & Chang, J-Y., 2010 Nov 1, In : PloS one. 5, 9, p. 1-11 11 p., e12564.

Research output: Contribution to journalArticle

drug resistance
Tubulin
tubulin
Drug Resistance
Microtubules
24 Citations (Scopus)

Chamaecypanone C, a novel skeleton microtubule inhibitor, with anticancer activity by trigger caspase 8-Fas/FasL dependent apoptotic pathway in human cancer cells

Hsieh, C. C., Kuo, Y. H., Kuo, C. C., Chen, L. T., Cheung, C-H., Chao, T. Y., Lin, C. H., Pan, W. Y., Chang, C. Y., Chien, S. C., Chen, T. W., Lung, C. C. & Chang, J-Y., 2010 May 1, In : Biochemical Pharmacology. 79, 9, p. 1261-1271 11 p.

Research output: Contribution to journalArticle

Caspase 8
Skeleton
Microtubules
Cells
Neoplasms
26 Citations (Scopus)

Proliferative and protective effects of SurR9-C84A on differentiated neural cells

Baratchi, S., Kanwar, R. K., Cheung, C-H. & Kanwar, J. R., 2010 Oct 1, In : Journal of Neuroimmunology. 227, 1-2, p. 120-132 13 p.

Research output: Contribution to journalArticle

Cytoprotection
Tretinoin
Mitosis
Microtubules
Cell Division
69 Citations (Scopus)

Recent advances in anti-survivin treatments for cancer

Kanwar, R. K., Cheung, C-H., Chang, J-Y. & Kanwar, J. R., 2010 Jun 18, In : Current Medicinal Chemistry. 17, 15, p. 1509-1515 7 p.

Research output: Contribution to journalArticle

Cells
Tumors
Apoptosis
Neoplasms
Chemotherapy
36 Citations (Scopus)

Targeting Hsp90 with small molecule inhibitors induces the over-expression of the anti-apoptotic molecule, survivin, in human A549, HONE-1 and HT-29 cancer cells

Cheung, C-H., Chen, H. H., Cheng, L. T., Lyu, K. W., Kanwar, J. R. & Chang, J-Y., 2010 Apr 15, In : Molecular cancer. 9, 77.

Research output: Contribution to journalArticle

HT29 Cells
tanespimycin
Neoplasms
Cell Line
Down-Regulation
2009
52 Citations (Scopus)

Survivin counteracts the therapeutic effect of microtubule de-stabilizers by stabilizing tubulin polymers

Cheung, C-H., Chen, H. H., Kuo, C. C., Chang, C. Y., Coumar, M. S., Hsieh, H. P. & Chang, J-Y., 2009 Jul 3, In : Molecular cancer. 8, 43.

Research output: Contribution to journalArticle

Therapeutic Uses
Tubulin
Microtubules
Polymers
Caspases