Chun-Hei Cheung

Associate Professor

  • 3375 Citations
  • 21 h-Index
20092020

Research output per year

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Research Output

  • 3375 Citations
  • 21 h-Index
  • 28 Article
  • 11 Review article
  • 3 Comment/debate
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Article
2019

Aging-induced Akt activation involves in aging-related pathologies and Aβ-induced toxicity

Chen, Y. R., Li, Y. H., Hsieh, T. C., Wang, C. M., Cheng, K. C., Wang, L., Lin, T. Y., Cheung, C. H. A., Wu, C. L. & Chiang, H. C., 2019 Aug, In : Aging Cell. 18, 4, e12989.

Research output: Contribution to journalArticle

Open Access

Cloning, expression, and purification of the recombinant pro-apoptotic dominant-negative survivin T34A-C84A protein in Escherichia coli

Tsai, S. L., Chang, Y. C., Sarvagalla, S., Wang, S., Coumar, M. S. & Cheung, C. H. A., 2019 Aug, In : Protein Expression and Purification. 160, p. 73-83 11 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Mutation of the PTCH1 gene predicts recurrence of breast cancer

Wang, C. Y., Chang, Y. C., Kuo, Y. L., Lee, K. T., Chen, P. S., Cheung, C. H. A., Chang, C. P., Phan, N. N., Shen, M. R. & Hsu, H. P., 2019 Nov 8, In : Scientific reports. 9, 1, 1 p., 16359.

Research output: Contribution to journalArticle

Open Access
2018

Dysfunction of different cellular degradation pathways contributes to specific β-amyloid42-induced pathologies

Ji, X. R., Cheng, K. C., Chen, Y. R., Lin, T. Y., Cheung, C. H. A., Wu, C. L. & Chiang, H. C., 2018 Mar, In : FASEB Journal. 32, 3, p. 1375-1387 13 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2017

HDAC2 and HDAC5 up-regulations modulate survivin and miR-125a-5p expressions and promote hormone therapy resistance in estrogen receptor positive breast cancer cells

Huang, W. T., Tsai, Y. H., Chen, S. H., Kuo, C. W., Kuo, Y. L., Lee, K. T., Chen, W. C., Wu, P. C., Chuang, C. Y., Cheng, S. M., Lin, C. H., Leung, E. Y., Chang, Y. C. & Cheung, C. H. A., 2017 Dec 13, In : Frontiers in Pharmacology. 8, DEC, 902.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Topical ophthalmic formulation of trichostatin A and SurR9-C84A for quick recovery post-alkali burn of corneal haze

Roy, K., Cheung, C. H. A., Kanwar, R. K., Sandhir, R. & Kanwar, J. R., 2017 May 5, In : Frontiers in Pharmacology. 8, MAY, 223.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2016

Delivery of a survivin Promoter-Driven antisense Survivin-Expressing plasmid DNA as a cancer therapeutic: A proof-of-concept study

Lin, K. Y., Cheng, S. M., Tsai, S. L., Tsai, J. Y., Lin, C. H. & Cheung, C. H. A., 2016 May 3, In : OncoTargets and Therapy. 9, p. 2601-2613 13 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Disruption of protein-protein interactions: Hot spot detection, structure-based virtual screening and: In vitro testing for the anti-cancer drug target-survivin

Sarvagalla, S., Cheung, C. H. A., Tsai, J. Y., Hsieh, H. P. & Coumar, M. S., 2016 Jan 1, In : RSC Advances. 6, 38, p. 31947-31959 13 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

E-Cadherin Aptamer-Conjugated Delivery of Doxorubicin for Targeted Inhibition of Prostate Cancer Cells

Chaudhary, R., Roy, K., Kanwar, R. K., Veedu, R. N., Krishnakumar, S., Cheung, C-H., Verma, A. K. & Kanwar, J. R., 2016 Jan 1, In : Australian Journal of Chemistry. 69, 10, p. 1108-1116 9 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Inhibition of HDAC3- and HDAC6-promoted survivin expression plays an important role in SAHA-induced autophagy and viability reduction in breast cancer cells

Lee, J. Y. C., Kuo, C. W., Tsai, S. L., Cheng, S. M., Chen, S. H., Chan, H. H., Lin, C. H., Lin, K. Y., Li, C. F., Kanwar, J. R., Leung, E. Y., Cheung, C. C. H., Huang, W. J., Wang, Y. C. & Cheung, C. H. A., 2016 Mar 31, In : Frontiers in Pharmacology. 7, MAR, 81.

Research output: Contribution to journalArticle

22 Citations (Scopus)
2015

Competitive inhibition of survivin using a cell-permeable recombinant protein induces cancer-specific apoptosis in colon cancer model

Roy, K., Kanwar, R. K., Krishnakumar, S., Cheung, C. H. A. & Kanwar, J. R., 2015 Feb 2, In : International journal of nanomedicine. 10, p. 1019-1043 25 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Locked nucleic acid modified bi-specific aptamer-targeted nanoparticles carrying survivin antagonist towards effective colon cancer therapy

Roy, K., Kanwar, R. K., Antonio Cheung, C. H., Lee Fleming, C., Veedu, R. N., Krishnakumar, S. & Kanwar, J. R., 2015 Jan 1, In : RSC Advances. 5, 37, p. 29008-29016 9 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

O6-methylguanine DNA methyltransferase repairs platinum-DNA adducts following cisplatin treatment and predicts prognoses of nasopharyngeal carcinoma

Chen, S. H., Kuo, C. C., Li, C. F., Cheung, C. H. A., Tsou, T. C., Chiang, H. C., Yang, Y. N., Chang, S. L., Lin, L. C., Pan, H. Y., Chang, K. Y. & Chang, J. Y., 2015 Sep 1, In : International Journal of Cancer. 137, 6, p. 1291-1305 15 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

YM155 down-regulates survivin and XIAP, modulates autophagy and induces autophagy-dependent DNA damage in breast cancer cells

Cheng, S. M., Chang, Y. C., Liu, C. Y., Lee, J. Y. C., Chan, H. H., Kuo, C. W., Lin, K. Y., Tsai, S. L., Chen, S. H., Li, C. F., Leung, E., Kanwar, J. R., Huang, C. C., Chang, J. Y. & Cheung, C. H. A., 2015 Jan, In : British Journal of Pharmacology. 172, 1, p. 214-234 21 p.

Research output: Contribution to journalArticle

44 Citations (Scopus)
2014

The inducible nitric-oxide synthase (iNOS)/Src axis mediates toll-like receptor 3 tyrosine 759 phosphorylation and enhances its signal transduction, leading to interferon- β synthesis in macrophages

Hsieh, M. Y., Chang, M. Y., Chen, Y. J., Li, Y. K., Chuang, T. H., Yu, G. Y., Cheung, C. H. A., Chen, H. C., Maa, M. C. & Leu, T. H., 2014 Mar 30, In : Journal of Biological Chemistry. 289, 13, p. 9208-9220 13 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)
2013
36 Citations (Scopus)
2012

Modulating the interaction of CXCR4 and CXCL12 by low-molecular-weight heparin inhibits hepatic metastasis of colon cancer

Ma, L., Qiao, H., He, C., Yang, Q., Cheung, C. H. A., Kanwar, J. R. & Sun, X., 2012 Apr 1, In : Investigational New Drugs. 30, 2, p. 508-517 10 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Targeting cathepsin S induces tumor cell autophagy via the EGFR-ERK signaling pathway

Chen, K. L., Chang, W. S. W., Cheung, C. H. A., Lin, C. C., Huang, C. C., Yang, Y. N., Kuo, C. P., Kuo, C. C., Chang, Y. H., Liu, K. J., Wu, C. M. & Chang, J. Y., 2012 Apr 1, In : Cancer Letters. 317, 1, p. 89-98 10 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)
2011

BPR1K653, a novel aurora kinase inhibitor, exhibits potent anti-proliferative activity in MDR1 (P-gp170)-mediated multidrug-resistant cancer cells

Cheung, C. H. A., Lin, W. H., HsuJohn, J. T. A., Hour, T. C., Yeh, T. K., Ko, S., Lien, T. W., Coumar, M. S., Liu, J. F., Lai, W. Y., Shiao, H. Y., Lee, T. R., Hsieh, H. P. & Chang, J. Y., 2011 Aug 24, In : PloS one. 6, 8, e23485.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Enhancement of non-homologous end joining DNA repair capacity confers cancer cells resistance to the novel selenophene compound, D-501036

Yang, Y. N., Chou, K. M., Pan, W. Y., Chen, Y. W., Tsou, T. C., Yeh, S. C., Cheung, C. H. A., Chen, L. T. & Chang, J. Y., 2011 Oct 1, In : Cancer Letters. 309, 1, p. 110-118 9 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Investigations of survivin: The past, present and future

Cheung, C. H. A., Cheng, L. T., Chang, K. Y., Chen, H. H. & Chang, J. Y., 2011 Jan 1, In : Frontiers in Bioscience. 16, 3, p. 952-961 10 p.

Research output: Contribution to journalArticle

46 Citations (Scopus)
2010

A cell-permeable dominant-negative survivin protein induces apoptosis and sensitizes prostate cancer cells to TNF-α therapy

Cheung, C. H. A., Sun, X., Kanwar, J. R., Bai, J. Z., Cheng, L. T. & Krissansen, G. W., 2010 Oct 1, In : Cancer Cell International. 10, 36.

Research output: Contribution to journalArticle

34 Citations (Scopus)

Cancer cells acquire mitotic drug resistance properties through beta i-tubulin mutations and alterations in the expression of beta-tubulin isotypes

Cheung, C. H. A., Wu, S. Y., Lee, T. R., Chang, C. Y., Wu, J. S., Hsieh, H. P. & Chang, J. Y., 2010 Nov 1, In : PloS one. 5, 9, p. 1-11 11 p., e12564.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Chamaecypanone C, a novel skeleton microtubule inhibitor, with anticancer activity by trigger caspase 8-Fas/FasL dependent apoptotic pathway in human cancer cells

Hsieh, C. C., Kuo, Y. H., Kuo, C. C., Chen, L. T., Cheung, C-H., Chao, T. Y., Lin, C. H., Pan, W. Y., Chang, C. Y., Chien, S. C., Chen, T. W., Lung, C. C. & Chang, J-Y., 2010 May 1, In : Biochemical Pharmacology. 79, 9, p. 1261-1271 11 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Proliferative and protective effects of SurR9-C84A on differentiated neural cells

Baratchi, S., Kanwar, R. K., Cheung, C. H. A. & Kanwar, J. R., 2010 Oct 1, In : Journal of Neuroimmunology. 227, 1-2, p. 120-132 13 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Recent advances in anti-survivin treatments for cancer

Kanwar, R. K., Cheung, C-H., Chang, J-Y. & Kanwar, J. R., 2010 Jun 18, In : Current Medicinal Chemistry. 17, 15, p. 1509-1515 7 p.

Research output: Contribution to journalArticle

69 Citations (Scopus)

Targeting Hsp90 with small molecule inhibitors induces the over-expression of the anti-apoptotic molecule, survivin, in human A549, HONE-1 and HT-29 cancer cells

Cheung, C-H., Chen, H. H., Cheng, L. T., Lyu, K. W., Kanwar, J. R. & Chang, J-Y., 2010 Apr 15, In : Molecular cancer. 9, 77.

Research output: Contribution to journalArticle

36 Citations (Scopus)
2009

Survivin counteracts the therapeutic effect of microtubule de-stabilizers by stabilizing tubulin polymers

Cheung, C. H. A., Chen, H. H., Kuo, C. C., Chang, C. Y., Coumar, M. S., Hsieh, H. P. & Chang, J. Y., 2009 Jul 3, In : Molecular cancer. 8, 43.

Research output: Contribution to journalArticle

55 Citations (Scopus)