• 1850 Citations
  • 21 h-Index
19962019

Research output per year

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Research Output

2019

A p53/TIAF1/WWOX triad exerts cancer suppression but may cause brain protein aggregation due to p53/WWOX functional antagonism

Chou, P. Y., Lin, S. R., Lee, M. H., Schultz, L., Sze, C. I. & Chang, N. S., 2019 Jul 17, In : Cell Communication and Signaling. 17, 1, 76.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

Editorial: WW Domain Proteins in Signaling, Cancer Growth, Neural Diseases, and Metabolic Disorders

Chang, N. S., Lin, R., Sze, C. I. & Aqeilan, R. I., 2019 Aug 2, In : Frontiers in Oncology. 9, 719.

Research output: Contribution to journalEditorial

Open Access

Strategies by which WWOX-deficient metastatic cancer cells utilize to survive via dodging, compromising, and causing damage to WWOX-positive normal microenvironment

Chou, P. Y., Lai, F. J., Chen, Y. A., Sie, Y. D., Kuo, H. L., Su, W. P., Wu, C. Y., Liu, T. Y., Wen, K. Y., Hsu, L. J., Sze, C. I. & Chang, N. S., 2019 Dec 1, In : Cell Death Discovery. 5, 1, 97.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)
2018

Glioblastoma cells labeled by robust Raman tags for enhancing imaging contrast

Huang, L. C., Chang, Y. C., Wu, Y. S., Sun, W. L., Liu, C. C., Sze, C. I. & Chen, S. Y., 2018 May 1, In : Biomedical Optics Express. 9, 5, p. 2142-2153 12 p., #320430.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Robust and brilliant Raman tags based on core-satellite assemblies for brain tumor cell imaging

Chang, Y. C., Huang, L. C., Sun, W. L., Chuang, S. Y., Lin, T. H., Wu, Y. S., Sze, C. I. & Chen, S. Y., 2018 Jan 1, Biomedical Vibrational Spectroscopy 2018: Advances in Research and Industry. Mahadevan-Jansen, A. & Petrich, W. (eds.). SPIE, 1049006. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 10490).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

WWOX phosphorylation, signaling, and role in neurodegeneration

Liu, C. C., Ho, P. C., Lee, I. T., Chen, Y. A., Chu, C. H., Teng, C. C., Wu, S. N., Sze, C. I., Chiang, M. F. & Chang, N. S., 2018 Aug 15, In : Frontiers in Neuroscience. 12, AUG, 563.

Research output: Contribution to journalReview article

7 Citations (Scopus)
2017
13 Citations (Scopus)
2016

A single postnatal dose of dexamethasone enhances memory of rat pups later in life

Tsai, K. J., Sze, C. I., Lin, Y. C., Lin, Y. J., Hsieh, T. H. & Lin, C. H., 2016 Oct, In : PloS one. 11, 10, e0165752.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Evidence for the Inhibition by Temozolomide, an Imidazotetrazine Family Alkylator, of Intermediate-Conductance Ca 2+ -Activated K + Channels in Glioma Cells

Yeh, P. S., Wu, S. J., Hung, T. Y., Huang, Y. M., Hsu, C. W., Sze, C. I., Hsieh, Y. J., Huang, C. W. & Wu, S. N., 2016 Jan 1, In : Cellular Physiology and Biochemistry. 38, 5, p. 1727-1742 16 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

HYAL-2-WWOX-SMAD4 signaling in cell death and anticancer response

Hsu, L. J., Chiang, M. F., Sze, C. I., Su, W. P., Yap, Y. V., Lee, I. T., Kuo, H. L. & Chang, N. S., 2016 Dec 6, In : Frontiers in Cell and Developmental Biology. 4, DEC, 141.

Research output: Contribution to journalReview article

Open Access
11 Citations (Scopus)

Zfra induction of memory anticancer response via a novel immune cell

Su, W. P., Wang, W. J., Sze, C. I. & Chang, N. S., 2016 Sep 1, In : OncoImmunology. 5, 9, e1213935.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2015

A cascade of protein aggregation bombards mitochondria for neurodegeneration and apoptosis under WWOX deficiency

Sze, C. I., Kuo, Y. M., Hsu, L. J., Fu, T. F., Chiang, M. F., Chang, J. Y. & Chang, N. S., 2015 Sep 10, In : Cell Death and Disease. 6, 9, e1881.

Research output: Contribution to journalComment/debate

13 Citations (Scopus)
5 Citations (Scopus)

Modulation of Sonic hedgehog signaling and WW domain containing oxidoreductase WOX1 expression enhances radiosensitivity of human glioblastoma cells

Chiang, M. F., Chen, H. H., Chi, C. W., Sze, C. I., Hsu, M. L., Shieh, H. R., Lin, C. P., Chen, Y. J. & Tsai, J. T., 2015 Mar 25, In : Experimental Biology and Medicine. 240, 3, p. 392-399 8 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Trafficking protein particle complex 6A delta (TRAPPC6AΔ) is an extracellular plaque-forming protein in the brain

Chang, J. Y., Lee, M. H., Lin, S. R., Yang, L. Y., Sunny Sun, H., Sze, C. I., Hong, Q., Lin, Y. S., Chou, Y. T., Hsu, L. J., Jan, M. S., Gong, C. X. & Chang, N. S., 2015 Jan 1, In : Oncotarget. 6, 6, p. 3578-3589 12 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)
2014

Cerebral microvascular damage occurs early after hypoxia-ischemia via nNOS activation in the neonatal brain

Hsu, Y. C., Chang, Y. C., Lin, Y-C., Sze, C-I., Huang, C-C. & Ho, C. J., 2014 Jan 1, In : Journal of Cerebral Blood Flow and Metabolism. 34, 4, p. 668-676 9 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

High-grade glioma in a patient with breast cancer

Chang, C. C., Tien, C. H., Tai, S. H., Chuang, M. T., Sze, C. I., Hung, Y. C. & Lee, E. J., 2014 Jul, In : Asian Journal of Surgery. 37, 3, p. 162-166 5 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Induction of apoptosis of malignant gliomas cells by a prenylated chalcone

Teng, C. C., Sze, C. I. & Liao, W. C., 2014 Apr 1, In : Pharmaceutical Biology. 52, 4, p. 471-478 8 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

WW domain-containing oxidoreductase in neuronal injury and neurological diseases

Chang, H. T., Liu, C. C., Chen, S. T., Yap, Y. V., Chang, N. S. & Sze, C. I., 2014 Jan 1, In : Oncotarget. 5, 23, p. 11792-11799 8 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)
2013

Assessing current therapeutic approaches to decode potential resistance mechanisms in glioblastomas

Sze, C. I., Su, W. P., Chiang, M. F., Lu, C. Y., Chen, Y. A. & Chang, N. S., 2013 Dec 24, In : Frontiers in Oncology. 3 MAR, Article 00059.

Research output: Contribution to journalShort survey

12 Citations (Scopus)

Direct radiofrequency application improves pain and gait in collagenase-induced acute achilles tendon injury

Tsai, Y. P., Chang, C. W., Lee, J. S., Liang, J. I., Hsieh, T. H., Yeh, M. L. & Sze, C. I., 2013 Dec 1, In : Evidence-based Complementary and Alternative Medicine. 2013, 402692.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Expression of WW domain-containing oxidoreductase WOX1 in human nervous system tumors

Chiang, M. F., Chen, S. T., Lo, C. P., Sze, C-I., Chang, N-S. & Chen, Y. J., 2013 Jan 1, In : Analytical Cellular Pathology. 36, 5-6, p. 133-147 15 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Quantitative proteomic analysis of the inhibitory effects of CIL-102 on viability and invasiveness in human glioma cells

Teng, C. C., Kuo, H. C. & Sze, C. I., 2013 Nov 1, In : Toxicology and Applied Pharmacology. 272, 3, p. 579-590 12 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Role of WWOX/WOX1 in Alzheimer's disease pathology and in cell death signaling

Teng, C. C., Yang, Y. T., Chen, Y. C., Kuo, Y-M. & Sze, C-I., 2013 Jan 1, In : Frontiers in Bioscience - Scholar. 5 S, 1, p. 72-85 14 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
19 Citations (Scopus)

Tumor suppressor WWOX and p53 alterations and drug resistance in glioblastomas

Chiang, M. F., Chou, P. Y., Wang, W. J., Sze, C. I. & Chang, N. S., 2013 Dec 24, In : Frontiers in Oncology. 3 MAR, Article 00043.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Visfatin induces stromal cell-derived factor-1 expression by β1 integrin signaling in colorectal cancer cells

Huang, W. S., Chen, C. N., Sze, C. I. & Teng, C. C., 2013 May 1, In : Journal of Cellular Physiology. 228, 5, p. 1017-1024 8 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)
2012

Delayed granulocyte colony-stimulating factor treatment promotes functional recovery in rats with severe contusive spinal cord injury

Lee, J. S., Yang, C. C., Kuo, Y. M., Sze, C. I., Hsu, J. Y. C., Huang, Y. H., Tzeng, S. F., Tsai, C. L., Chen, H. H. & Jou, I. M., 2012 Jan 1, In : Spine. 37, 1, p. 10-17 8 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Role of WWOX/WOX1 in Alzheimer's disease pathology and in cell death signaling

Teng, C. C., Yang, Y. T., Chen, Y. C., Kuo, Y. M. & Sze, C. I., 2012 Jan 1, In : Frontiers in Bioscience - Elite. 4 E, 5, p. 1951-1965 15 p.

Research output: Contribution to journalReview article

7 Citations (Scopus)

The inhibitory effect of CIL-102 on the growth of human astrocytoma cells is mediated by the generation of reactive oxygen species and induction of ERK1/2 MAPK

Teng, C. C., Kuo, H. C., Cheng, H. C., Wang, T. C. & Sze, C-I., 2012 Aug 15, In : Toxicology and Applied Pharmacology. 263, 1, p. 73-80 8 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

TIAF1 self-aggregation in peritumor capsule formation, spontaneous activation of SMAD-responsive promoter in p53-deficient environment, and cell death

Chang, J. Y., Chiang, M. F., Lin, S. R., Lee, M. H., He, H., Chou, P. Y., Chen, S. J., Chen, Y. A., Yang, L. Y., Lai, F. J., Hsieh, C. C., Hsieh, T. H., Sheu, H. M., Sze, C. I. & Chang, N. S., 2012 Apr 1, In : Cell Death and Disease. 3, 4, e302.

Research output: Contribution to journalArticle

18 Citations (Scopus)
2011

Cell line studies of glioblastoma and malignant glioma using a newly discovered prenylated chalcone

Teng, C. C., Sze, C. I., Wang, T. C., Lien, C. Y. & Liao, W. C., 2011 Mar 1, In : Pharmaceutical Biology. 49, 3, p. 314-318 5 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Downregulation of CREB expression in Alzheimer's brain and in Aβ-treated rat hippocampal neurons

Pugazhenthi, S., Wang, M., Pham, S., Sze, C. I. & Eckman, C. B., 2011 Aug 23, In : Molecular Neurodegeneration. 6, 1, 60.

Research output: Contribution to journalArticle

114 Citations (Scopus)
2010

Malignant sweat gland tumor presenting as an unusual dural-based lesion: Case report

Lee, J. S., Chang, K. C., Chen, H. H. & Sze, C. I., 2010 Sep 1, In : Journal of Neuro-Oncology. 99, 2, p. 273-276 4 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

TGF-β induces TIAF1 self-aggregation via type II receptor-independent signaling that leads to generation of amyloid β plaques in Alzheimer's disease

Lee, M. H., Lin, S. R., Chang, J. Y., Schultz, L., Heath, J., Hsu, L. J., Kuo, Y. M., Hong, Q., Chiang, M. F., Gong, C. X., Sze, C. I. & Chang, N. S., 2010 Dec 1, In : Cell Death and Disease. 1, 12, e110.

Research output: Contribution to journalArticle

34 Citations (Scopus)
2009

Complement C1q activates tumor suppressor WWOX to induce apoptosis in prostate cancer cells

Hong, Q., Sze, C. I., Lin, S. R., Lee, M. H., He, R. Y., Schultz, L., Chang, J. Y., Chen, S. J., Boackle, R. J., Hsu, L. J. & Chang, N. S., 2009 Jun 1, In : PloS one. 4, 6, e5755.

Research output: Contribution to journalArticle

64 Citations (Scopus)

Dramatic co-activation of WWOX/WOX1 with CREB and NF-κB in delayed loss of small dorsal root ganglion neurons upon sciatic nerve transection in rats

Li, M. Y., Lai, F. J., Hsu, L. J., Lo, C. P., Cheng, C. L., Lin, S. R., Lee, M. H., Chang, J. Y., Subhan, D., Tsai, M. S., Sze, C. I., Pugazhenthi, S., Chang, N. S. & Chen, S. T., 2009 Nov 12, In : PloS one. 4, 11, e7820.

Research output: Contribution to journalArticle

36 Citations (Scopus)
2008

Subconjunctival mitomycin C before pterygium excision: An ultrastructural study

Chang, Y. S., Chen, W. C., Tseng, S. H., Sze, C. I. & Wu, C. L., 2008 May 1, In : Cornea. 27, 4, p. 471-475 5 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)
2005
64 Citations (Scopus)

X-ray microbeams: Tumor therapy and central nervous system research

Dilmanian, F. A., Qu, Y., Liu, S., Cool, C. D., Gilbert, J., Hainfeld, J. F., Kruse, C. A., Laterra, J., Lenihan, D., Nawrocky, M. M., Pappas, G., Sze, C. I., Yuasa, T., Zhong, N., Zhong, Z. & McDonald, J. W., 2005 Aug 11, In : Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment. 548, 1-2, p. 30-37 8 p.

Research output: Contribution to journalConference article

50 Citations (Scopus)
2004

Down-regulation of WW domain-containing oxidoreductase induces Tau phosphorylation in vitro: A potential role in Alzheimer's disease

Sze, C. I., Su, M., Pugazhenthi, S., Jambal, P., Hsu, L. J., Heath, J., Schultz, L. & Chang, N. S., 2004 Jul 16, In : Journal of Biological Chemistry. 279, 29, p. 30498-30506 9 p.

Research output: Contribution to journalArticle

78 Citations (Scopus)

Experimental intrauterine infection with Prevotella bivia in New Zealand White rabbits

Gibbs, R. S., McDuffie, R. S., Kunze, M., Barr, J. M., Wolf, D. M., Sze, C. I., Shikes, R. & Sherman, M. P., 2004 Apr, In : American Journal of Obstetrics and Gynecology. 190, 4, p. 1082-1086 5 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Silent corticotroph adenomas: Further clinical and pathological observations

Lopez, J. A., Kleinschmidt-Demasters, B. K., Sze, C. I., Woodmansee, W. W. & Lillehei, K. O., 2004 Sep 1, In : Human Pathology. 35, 9, p. 1137-1147 11 p.

Research output: Contribution to journalArticle

45 Citations (Scopus)

Synovial excrescences and cysts of the spine: Clinicopathological features and contributions to spinal stenosis

Sze, C. I., Kindt, G., Huffer, W. B., Chang, M., Wang, M. & Kleinschmidt-DeMasters, B. K., 2004 Mar 1, In : Clinical Neuropathology. 23, 2, p. 80-90 11 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)
2003

Intracalvarial cholesterol granulomas - Clinicopathologic correlates of three cases

Sze, C. I., Huffer, W., Breeze, R., Escott, E. & Kleinschmidt-DeMasters, B. K., 2003 Jan 1, In : Clinical Neuropathology. 22, 1, p. 41-46 6 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2002

Chronic intrauterine and fetal infection with Gardnerella vaginalis

McDuffie, R. S., Kunze, M., Barr, J., Wolf, D., Sze, C. I., Shikes, R., Sherman, M. & Gibbs, R. S., 2002 Nov 1, In : American Journal of Obstetrics and Gynecology. 187, 5, p. 1263-1266 4 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)
76 Citations (Scopus)
2001

N-Methyl-D-aspartate receptor subunit proteins and their phosphorylation status are altered selectively in Alzheimer's disease

Sze, C. I., Bi, H., Kleinschmidt-DeMasters, B. K., Filley, C. M. & Martin, L. J., 2001 Jan 1, In : Journal of the Neurological Sciences. 182, 2, p. 151-159 9 p.

Research output: Contribution to journalArticle

97 Citations (Scopus)

Suprasellar cavernous malformation presenting with extensive subarachnoid hemorrhage

Escott, E. J., Rubinstein, D., Cajade-Law, A. G. & Sze, C. I., 2001 Jan 1, In : Neuroradiology. 43, 4, p. 313-316 4 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)
2000

Histologic inflammation in the maternal and fetal compartments in a rabbit model of acute intra-amniotic infection

Davies, J. K., Shikes, R. H., Sze, C. I., Leslie, K. K., McDuffie, R. S., Romero, R. & Gibbs, R. S., 2000 Jan 1, In : American Journal of Obstetrics and Gynecology. 183, 5, p. 1088-1093 6 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)