E-Jian Lee

Professor

  • 2047 Citations
  • 27 h-Index
19952020
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Research Output 1995 2019

2019

Chemical constituents from the stems of Machilus philippinensis Merr. and the neuroprotective activity of cinnamophilin

Tai, S. H., Kuo, P. C., Lam, S. H., Huang, S. C., Kuo, Y. Z., Hung, H. Y., Liou, M. J., Shieh, P. C., Lee, E. J. & Wu, T. S., 2019 Jan 1, In : RSC Advances. 9, 38, p. 21616-21625 10 p.

Research output: Contribution to journalArticle

Open Access
Acids
Bioactivity
Neurons
Medicine
Methanol
2018
2 Citations (Scopus)
Transient Ischemic Attack
Reperfusion Injury
Oxygen
Glucose
Brain
11 Citations (Scopus)

Melatonin protects brain against ischemia/reperfusion injury by attenuating endoplasmic reticulum stress

Lin, Y. W., Chen, T. Y., Hung, C. Y., Tai, S. H., Huang, S. Y., Chang, C. C., Hung, H. Y. & Lee, E. J., 2018 Jul, In : International journal of molecular medicine. 42, 1, p. 182-192 11 p.

Research output: Contribution to journalArticle

Endoplasmic Reticulum Stress
Melatonin
Reperfusion Injury
Brain Ischemia
Eukaryotic Initiation Factor-2
1 Citation (Scopus)
Dendritic Spines
Transient Ischemic Attack
Brain Ischemia
Neuronal Plasticity
Stroke

Taiwan neurosurgical spine society: The new shining star

Kuo, Y. H., Wu, J. C., Huang, W. C., Huang, M. C., Lee, E-J. & Cheng, H., 2018 Dec 1, In : Neurospine. 15, 4, p. 285-295 11 p.

Research output: Contribution to journalArticle

Open Access
Taiwan
Spine
Neurosurgery
Research
Japan
1 Citation (Scopus)

Taiwan neurosurgical spine society: Move together in “neurospine” toward clinical and academic success

Lee, E. J., 2018 Mar, In : Neurospine. 15, 1, 1 p.

Research output: Contribution to journalComment/debate

Open Access
Taiwan
Spine
1 Citation (Scopus)

Therapeutic window for YC-1 following glutamate-induced neuronal damage and transient focal cerebral ischemia

Tai, S. H., Lee, W. T., Lee, A. C., Lin, Y. W., Hung, H. Y., Huang, S. Y., Wu, T. S. & Lee, E. J., 2018 May, In : Molecular Medicine Reports. 17, 5, p. 6490-6496 7 p.

Research output: Contribution to journalArticle

Transient Ischemic Attack
Glutamic Acid
Neurons
Therapeutics
Stroke

YC-1 reduces inflammatory responses by inhibiting nuclear factor-?B translocation in mice subjected to transient focal cerebral ischemia

Lee, W. T., Tai, S. H., Lin, Y. W., Wu, T. S. & Lee, E. J., 2018 Aug, In : Molecular Medicine Reports. 18, 2, p. 2043-2051 9 p.

Research output: Contribution to journalArticle

Transient Ischemic Attack
Brain
Stroke
Indazoles
Macrophages
2017
3 Citations (Scopus)

Anti-inflammatory Flavan-3-ol-dihydroretrochalcones from Daemonorops draco

Kuo, P-C., Hung, H-Y., Hwang, T. L., Du, W. K., Ku, H. C., Lee, E-J., Tai, S-H., Chen, F. A. & Wu, T-S., 2017 Apr 28, In : Journal of Natural Products. 80, 4, p. 783-789 7 p.

Research output: Contribution to journalArticle

Anti-Inflammatory Agents
Pancreatic Elastase
Chinese Traditional Medicine
Superoxides
Dimers
16 Citations (Scopus)

Chemical Constituents and Anti-inflammatory Principles from the Fruits of Forsythia suspensa

Kuo, P-C., Hung, H-Y., Nian, C. W., Hwang, T. L., Cheng, J. C., Kuo, D. H., Lee, E-J., Tai, S-H. & Wu, T-S., 2017 Apr 28, In : Journal of Natural Products. 80, 4, p. 1055-1064 10 p.

Research output: Contribution to journalArticle

Forsythia
Lignans
Diterpenes
Pancreatic Elastase
Fruits

Comparison of fresh/frozen isolation method in DNA preparation of meningiomas for flow cytometry

Tai, S-H., Lin, Y. W., Chen, T. Y., Huang, Y. H., Hong, Y-C. & Lee, E-J., 2017 Jan 1, In : International Journal of Clinical and Experimental Pathology. 10, 11, p. 11057-11062 6 p.

Research output: Contribution to journalArticle

Meningioma
Flow Cytometry
G2 Phase
Cell Division
DNA
2016
10 Citations (Scopus)

Anti-inflammatory neolignans from the roots of Magnolia officinalis

Shih, H. C., Kuo, P. C., Wu, S. J., Hwang, T. L., Hung, H. Y., Shen, D. Y., Shieh, P. C., Liao, Y. R., Lee, E. J., Gu, Q., Lee, K. H. & Wu, T. S., 2016 Apr 1, In : Bioorganic and Medicinal Chemistry. 24, 7, p. 1439-1445 7 p.

Research output: Contribution to journalArticle

Magnolia
Lignans
Anti-Inflammatory Agents
Derivatives
Pancreatic Elastase

Application of flow cytometry for evaluating clinical prognosis and histopathological grade of human glioma

Lin, Y. W., Tai, S-H., Chang, C-C., Chao, L-C., Wen, M-J., Huang, Y. H., Hung, H-Y. & Lee, E-J., 2016 Apr 21, In : Neurological Research. 38, 7, p. 625-633 9 p.

Research output: Contribution to journalArticle

G2 Phase
Glioma
Cell Division
Flow Cytometry
Cyclin B
6 Citations (Scopus)

Erratum: Dragonbloodin A1 and A2: Flavan Trimers and Anti-inflammatory Principles from Sanguis Draconis (Organic Letters)

Du, W. K., Hung, H. Y., Kuo, P. C., Hwang, T. L., Shiu, L. C., Shiu, K. B., Lee, E. J., Tai, S. H. & Wu, T. S., 2016 Jun 17, In : Organic Letters. 18, 12, 1 p.

Research output: Contribution to journalComment/debate

2015
4 Citations (Scopus)

Chemical Constituents from the Fruiting Bodies of Hexagonia apiaria and Their Anti-inflammatory Activity

Thang, T. D., Kuo, P. C., Ngoc, N. T. B., Hwang, T. L., Yang, M. L., Ta, S. H., Lee, E. J., Kuo, D. H., Hung, N. H., Tuan, N. N. & Wu, T-S., 2015 Nov 25, In : Journal of Natural Products. 78, 11, p. 2552-2558 7 p.

Research output: Contribution to journalArticle

Anti-Inflammatory Agents
Pancreatic Elastase
Superoxides
7 Citations (Scopus)

The application of flow cytometry for evaluating biological aggressiveness of intracranial meningiomas

Lin, Y. W., Tai, S-H., Huang, Y. H., Chang, C-C., Juan, W. S., Chao, L-C., Wen, M-J., Hong, Y-C. & Lee, E-J., 2015 Sep 1, In : Cytometry Part B - Clinical Cytometry. 88, 5, p. 312-319 8 p.

Research output: Contribution to journalArticle

G2 Phase
Meningioma
Cell Division
Flow Cytometry
Cyclin B
2014
48 Citations (Scopus)

Constituents of the roots of Clausena lansium and their potential anti-inflammatory activity

Shen, D. Y., Chan, Y. Y., Hwang, T. L., Juang, S. H., Huang, S. C., Kuo, P-C., Thang, T. D., Lee, E-J., Damu, A. G. & Wu, T-S., 2014 May 23, In : Journal of Natural Products. 77, 5, p. 1215-1223 9 p.

Research output: Contribution to journalArticle

Clausena
Coumarins
Spectroscopic analysis
Pancreatic Elastase
Alkaloids
1 Citation (Scopus)

High-grade glioma in a patient with breast cancer

Chang, C-C., Tien, C-H., Tai, S-H., Chuang, M-T., Sze, C-I., Hong, Y-C. & Lee, E-J., 2014 Jan 1, In : Asian Journal of Surgery. 37, 3, p. 162-166 5 p.

Research output: Contribution to journalArticle

Glioma
Breast Neoplasms
Brain Neoplasms
Oligodendroglioma
Brain
27 Citations (Scopus)
GAP-43 Protein
Post-Synaptic Density
Neuronal Plasticity
Transient Ischemic Attack
Melatonin
3 Citations (Scopus)

Synthesis and structural characterization of an anti-inflammatory principle purified from Lindera aggregata

Kuo, P. C., Li, Y. C., Hwang, T. L., Ma, G. H., Yang, M. L., Lee, E. J. & Wu, T-S., 2014 Jan 1, In : Tetrahedron Letters. 55, 1, p. 108-110 3 p.

Research output: Contribution to journalArticle

Lindera
Superoxides
Anti-Inflammatory Agents
Cytochalasin B
Pancreatic Elastase
2013
16 Citations (Scopus)

Honokiol Dimers and Magnolol Derivatives with New Carbon Skeletons from the Roots of Magnolia officinalis and Their Inhibitory Effects on Superoxide Anion Generation and Elastase Release

Shih, H. C., Hwang, T. L., Chen, H. C., Kuo, P-C., Lee, E-J., Lee, K. H. & Wu, T-S., 2013 May 7, In : PloS one. 8, 5, e59502.

Research output: Contribution to journalArticle

Magnolia
elastase
Pancreatic Elastase
Oligomers
Skeleton
3 Citations (Scopus)

Isolated oculomotor nerve palsy caused by diffuse large B cell lymphoma

Tsai, C. H., Lee, E-J., Liu, Y-S., Chen, Y-C., Shih, Y-H. & Chuang, M-T., 2013 Jan 1, In : Acta Neurologica Belgica. 113, 1, p. 103-104 2 p.

Research output: Contribution to journalArticle

Oculomotor Nerve Diseases
Lymphoma, Large B-Cell, Diffuse
2012
22 Citations (Scopus)

A concise synthesis of viscolin, and its anti-inflammatory effects through the suppression of iNOS, COX-2, ERK phosphorylation and proinflammatory cytokines expressions

Huang, G. J., Bhaskar Reddy, M. V., Kuo, P. C., Huang, C. H., Shih, H. C., Lee, E. J., Yang, M. L., Leu, Y. L. & Wu, T. S., 2012 Feb 1, In : European Journal of Medicinal Chemistry. 48, p. 371-378 8 p.

Research output: Contribution to journalArticle

Phosphorylation
Anti-Inflammatory Agents
Cytokines
Macrophages
Western Blotting
3 Citations (Scopus)

An efficient synthesis of a potent anti-inflammatory agent, viscolin, and its inducible nitric oxide synthase inhibitory activity

Kuo, P. C., Chen, Y. H., Leu, Y. L., Huang, C. H., Liao, Y. R., Lee, E. J., Yang, M. L. & Wu, T-S., 2012 Apr 1, In : Chemical and Pharmaceutical Bulletin. 60, 4, p. 557-561 5 p.

Research output: Contribution to journalArticle

Chalcone
Nitric Oxide Synthase Type II
Anti-Inflammatory Agents
Hydrogenation
Bioactivity

Cervical spinal subarachnoid hematoma caused by head injury

Chang, C. C., Hung, Y. C. & Lee, E. J., 2012 Oct 1, In : Formosan Journal of Surgery. 45, 5, p. 164-166 3 p.

Research output: Contribution to journalArticle

Craniocerebral Trauma
Hematoma
Literature
Neurologic Manifestations
Causality
12 Citations (Scopus)

High risk of cross-reactivity between vancomycin and sequential teicoplanin therapy

Hsiao, S. H., Chou, C. H., Lin, W. L., Lee, E. J., Liao, L. H., Chang, H. J., Yeh, P. Y., Lin, C. Y. & Wu, T. J., 2012 Jun 1, In : Journal of Clinical Pharmacy and Therapeutics. 37, 3, p. 296-300 5 p.

Research output: Contribution to journalArticle

Teicoplanin
Vancomycin
Neutropenia
Glycopeptides
Therapeutics
5 Citations (Scopus)

Intracranial Rosai-Dorfman disease with unusual transcranial extension

Lu, C-H., Chang, K-C., Lee, E-J., Chuang, M-T. & Chang, R-S., 2012 Jul 1, In : Journal of Neuroimaging. 22, 3, p. 312-315 4 p.

Research output: Contribution to journalArticle

Sinus Histiocytosis
Therapeutics
11 Citations (Scopus)

Magnolol reduces glutamate-induced neuronal excitotoxicity and protects against permanent focal cerebral ischemia up to 4 hours

Lee, W. T., Lin, M. H., Lee, E-J., Hong, Y-C., Tai, S-H., Chen, H. Y., Chen, T. Y. & Wu, T-S., 2012 Jul 9, In : PloS one. 7, 7, e39952.

Research output: Contribution to journalArticle

ischemia
Brain Ischemia
glutamates
Glutamic Acid
infarction
15 Citations (Scopus)

Melatonin inhibits matrix metalloproteinase-9 (MMP-9) activation in the lipopolysaccharide (LPS)-stimulated RAW 264.7 and BV2 cells and a mouse model of meningitis

Chang, C. C., Tien, C. H., Lee, E. J., Juan, W. S., Chen, Y. H., Hung, Y. C., Chen, T. Y., Chen, H. Y. & Wu, T. S., 2012 Sep 1, In : Journal of Pineal Research. 53, 2, p. 188-197 10 p.

Research output: Contribution to journalArticle

Matrix Metalloproteinase 9
Melatonin
Meningitis
Lipopolysaccharides
NF-kappa B
4 Citations (Scopus)
Hematoma, Subdural, Chronic
Membranes
Hematoma
Therapeutics
Ventriculoperitoneal Shunt
12 Citations (Scopus)

Nicotinamide inhibits nuclear factor-kappa B translocation after transient focal cerebral ischemia

Chen, T. Y., Lin, M. H. S., Lee, W. T., Huang, S. Y., Chen, Y. H., Lee, A. C., Lin, H. W. & Lee, E-J., 2012 Feb 1, In : Critical Care Medicine. 40, 2, p. 532-537 6 p.

Research output: Contribution to journalArticle

Niacinamide
NF-kappa B
Transient Ischemic Attack
Anti-Inflammatory Agents
Lipopolysaccharides
19 Citations (Scopus)

Optimal Percoll concentration facilitates flow cytometric analysis for annexin V/propidium iodine-stained ischemic brain tissues

Juan, W. S., Lin, H. W., Chen, Y. H., Chen, H. Y., Hong, Y-C., Tai, S-H., Huang, S. Y., Chen, T. Y. & Lee, E-J., 2012 May 1, In : Cytometry Part A. 81 A, 5, p. 400-408 9 p.

Research output: Contribution to journalArticle

Propidium
Annexin A5
Iodine
Brain
Phenotype
7 Citations (Scopus)
Craniotomy
Hemorrhage
Neurosurgical Procedures
Atrophy
Drainage
2011
6 Citations (Scopus)

A retrospective survey of patients with malignant gliomas treated in the neuro-oncological care system under the Universal National Health Insurance program in Taiwan

Huang, Y. C., Wei, K. C., Chang, C. H., Yang, J. T., Ho, J. T., Shen, C. C., Su, C. F., Cho, D. Y., Ma, H. I., Lin, J. W., Lee, E-J., Wu, J. J., Tsai, M. D., Chang, C. K., Howng, S. L. & Chang, C. N., 2011 Jun 1, In : Journal of Clinical Neuroscience. 18, 6, p. 784-788 5 p.

Research output: Contribution to journalArticle

National Health Programs
Taiwan
Glioma
Survival Rate
temozolomide
27 Citations (Scopus)

Biologically active constituents from the fruiting body of Taiwanofungus camphoratus

Shi, L. S., Chao, C. H., Shen, D. Y., Chan, H. H., Chen, C. H., Liao, Y. R., Wu, S. J., Leu, Y. L., Shen, Y. C., Kuo, Y. H., Lee, E. J., Qian, K., Wu, T. S. & Lee, K. H., 2011 Jan 1, In : Bioorganic and Medicinal Chemistry. 19, 1, p. 677-683 7 p.

Research output: Contribution to journalArticle

Anti-Inflammatory Agents
Lignans
Spectroscopic analysis
Second Primary Neoplasms
Chinese Traditional Medicine
16 Citations (Scopus)

Cinnamophilin offers prolonged neuroprotection against gray and white matter damage and improves functional and electrophysiological outcomes after transient focal cerebral ischemia

Chen, T. Y., Tai, S-H., Lee, E-J., Huang, C. C., Lee, A. C., Huang, S. Y. & Wu, T-S., 2011 Jan 1, In : Critical Care Medicine. 39, 5, p. 1130-1137 8 p.

Research output: Contribution to journalArticle

Transient Ischemic Attack
Stroke
Myelin Sheath
Gray Matter
Neuroprotection
28 Citations (Scopus)

Melatonin protects against transient focal cerebral ischemia in both reproductively active and estrogen-deficient female rats: The impact of circulating estrogen on its hormetic dose-response

Tai, S-H., Hong, Y-C., Lee, E-J., Lee, A. C., Chen, T. Y., Shen, C. C., Chen, H. Y., Lee, M. Y., Huang, S. Y. & Wu, T-S., 2011 Apr 1, In : Journal of Pineal Research. 50, 3, p. 292-303 12 p.

Research output: Contribution to journalArticle

Hormesis
Transient Ischemic Attack
Melatonin
Estrogens
Estradiol
2010
4 Citations (Scopus)
Spinal Cord Compression
Prostate
Lymphoma
Thorax
Carcinoma
32 Citations (Scopus)

Camphoratins A-J, potent cytotoxic and anti-inflammatory triterpenoids from the fruiting body of Taiwanofungus camphoratus

Wu, S. J., Leu, Y. L., Chen, C. H., Chao, C. H., Shen, D. Y., Chan, H. H., Lee, E. J., Wu, T. S., Wang, Y. H., Shen, Y. C., Qian, K., Bastow, K. F. & Lee, K. H., 2010 Nov 29, In : Journal of Natural Products. 73, 11, p. 1756-1762 7 p.

Research output: Contribution to journalArticle

Spectroscopic analysis
Cytotoxicity
Inhibitory Concentration 50
Anti-Inflammatory Agents
Cells
7 Citations (Scopus)

Early reperfusion improves the recovery of contralateral electrophysiological diaschisis following focal cerebral ischemia in rats

Hong, Y-C., Chou, Y. S., Chang, C-H., Lin, H. W., Chen, H. Y., Chen, T. Y., Tai, S-H. & Lee, E-J., 2010 Oct 1, In : Neurological Research. 32, 8, p. 828-834 7 p.

Research output: Contribution to journalArticle

Somatosensory Evoked Potentials
Brain Ischemia
Reperfusion
Brain Infarction
Ischemia
41 Citations (Scopus)

Melatonin inhibits postischemic matrix metalloproteinase-9 (MMP-9) activation via dual modulation of plasminogen/plasmin system and endogenous MMP inhibitor in mice subjected to transient focal cerebral ischemia

Tai, S-H., Chen, H. Y., Lee, E-J., Chen, T. Y., Lin, H. W., Hong, Y-C., Huang, S. Y., Chen, Y. H., Lee, W. T. & Wu, T-S., 2010 Nov 1, In : Journal of Pineal Research. 49, 4, p. 332-341 10 p.

Research output: Contribution to journalArticle

Matrix Metalloproteinase Inhibitors
Plasminogen
Fibrinolysin
Transient Ischemic Attack
Matrix Metalloproteinase 9
1 Citation (Scopus)
Cerebellar Diseases
X Ray Computed Tomography
Intracranial Hemorrhages
Craniotomy
Neurosurgery
2009
2 Citations (Scopus)

A Rare Occipital Condyle Fracture in a Patient With A Minor Head Injury

Huang, D. W., Tai, S-H., Hong, Y-C., Fang, V. K., Lee, M. Y. & Lee, E-J., 2009 Jun 1, In : Kaohsiung Journal of Medical Sciences. 25, 6, p. 342-346 5 p.

Research output: Contribution to journalArticle

Craniocerebral Trauma
Bone and Bones
Neck Pain
Delayed Diagnosis
Rare Diseases
6 Citations (Scopus)
Ventriculoperitoneal Shunt
Hemorrhage
Caregivers
8 Citations (Scopus)
Imidazolines
Brain Ischemia
Oxides
Ischemia
Energy Metabolism
30 Citations (Scopus)

Effects of melatonin in experimental stroke models in acute, sub-acute, and chronic stages

Lin, H. W. & Lee, E-J., 2009 Nov 24, In : Neuropsychiatric Disease and Treatment. 5, 1, p. 157-162 6 p.

Research output: Contribution to journalReview article

Melatonin
Theoretical Models
Stroke
Brain Ischemia
Antioxidants

Effects of propofol sedation during the early postoperative period in hemorrhagic stroke patients

Hong, Y-C., Lee, E-J., Chen, H. Y., Ko, S. W., Shyr, M. H. & Chen, T. Y., 2009 Jan 1, In : Acta Anaesthesiologica Taiwanica. 47, 3, p. 128-133 6 p.

Research output: Contribution to journalArticle

Propofol
Postoperative Period
Stroke
Craniotomy
Nervous System

Magnesium treatment and spontaneous mild hypothermia after transient focal cerebral ischemia in the rat

Chen, H. Y., Tai, S-H. & Lee, E-J., 2009 May 29, In : Brain Research Bulletin. 79, 3-4, p. 224-225 2 p.

Research output: Contribution to journalLetter

Induced Hypothermia
Transient Ischemic Attack
Neuroprotective Agents
Hypothermia
Magnesium
27 Citations (Scopus)

Melatonin improves presynaptic protein, SNAP-25, expression and dendritic spine density and enhances functional and electrophysiological recovery following transient focal cerebral ischemia in rats

Lee, E-J., Chen, H. Y., Hong, Y-C., Chen, T. Y., Huang, S. Y., Wang, Y. H., Lee, W. T. & Wu, T-S., 2009 Oct 1, In : Journal of Pineal Research. 47, 3, p. 260-270 11 p.

Research output: Contribution to journalArticle

Synaptosomal-Associated Protein 25
Dendritic Spines
Transient Ischemic Attack
Melatonin
Brain
20 Citations (Scopus)

The protective efficacy of magnolol in hind limb ischemia-reperfusion injury

Chen, H. Y., Hong, Y-C., Lee, E-J., Chen, T. Y., Chuang, I. C. & Wu, T-S., 2009 Oct 1, In : Phytomedicine. 16, 10, p. 976-981 6 p.

Research output: Contribution to journalArticle

Reperfusion Injury
Extremities
Malondialdehyde
Peroxidase
Reperfusion