• 370 Citations
  • 13 h-Index
20132020
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Research Output 2013 2020

  • 370 Citations
  • 13 h-Index
  • 39 Article
  • 6 Letter
  • 2 Comment/debate
  • 2 Review article
2020

Effects of sodium-glucose co-transporter-2 inhibitors on serum alanine aminotransferase levels in people with type 2 diabetes: A multi-institutional cohort study

Shao, S. C., Chang, K. C., Chien, R. N., Lin, S. J., Hung, M. J., Chan, Y. Y., Kao Yang, Y. H. & Lai, E. C. C., 2020 Jan 1, In : Diabetes, Obesity and Metabolism. 22, 1, p. 128-134 7 p.

Research output: Contribution to journalArticle

Sodium-Glucose Transporter 2
Symporters
Alanine Transaminase
Type 2 Diabetes Mellitus
Cohort Studies
2019
1 Citation (Scopus)

Comparative risk evaluation for cardiovascular events associated with dapagliflozin vs. empagliflozin in real-world type 2 diabetes patients: A multi-institutional cohort study

Shao, S. C., Chang, K. C., Hung, M. J., Yang, N. I., Chan, Y. Y., Chen, H. Y., Kao Yang, Y. H. & Lai, E. C. C., 2019 Sep 24, In : Cardiovascular Diabetology. 18, 1, 120.

Research output: Contribution to journalArticle

Open Access
Type 2 Diabetes Mellitus
Sodium-Glucose Transporter 2
Cohort Studies
Symporters
Heart Failure
2 Citations (Scopus)

Incidence of type 2 diabetes mellitus in men receiving steroid 5α-reductase inhibitors: Population based cohort study

Wei, L., Lai, E. C. C., Kao-Yang, Y. H., Walker, B. R., MacDonald, T. M. & Andrew, R., 2019 Jan 1, In : BMJ (Online). 365, l1204.

Research output: Contribution to journalArticle

Open Access
tamsulosin
Finasteride
Type 2 Diabetes Mellitus
Oxidoreductases
Cohort Studies
Myositis
Taiwan
Coronary Disease
Population
Cohort Studies
1 Citation (Scopus)

Letter: contraindicated drug-drug interactions before and after initiation of direct-acting anti-viral agents in chronic hepatitis C patients in Taiwan

Shao, S. C., Lai, E. C. C., Chang, K. C., Chan, Y. Y., Chen, H. Y. & Chien, R. N., 2019 Jul, In : Alimentary Pharmacology and Therapeutics. 50, 1, p. 113-115 3 p.

Research output: Contribution to journalLetter

Open Access

Sodium glucose co-transporter 2 inhibitors and cardiovascular event protections: How applicable are clinical trials and observational studies to real-world patients?

Shao, S. C., Lin, Y. H., Chang, K. C., Chan, Y. Y., Hung, M. J., Kao Yang, Y. H. & Lai, E. C. C., 2019 Dec 30, In : BMJ Open Diabetes Research and Care. 7, 1, e000742.

Research output: Contribution to journalArticle

Open Access
Sodium-Glucose Transporter 2
Symporters
Observational Studies
Clinical Trials
Type 2 Diabetes Mellitus
20 Citations (Scopus)

Taiwan’s national health insurance research database: Past and future

Hsieh, C. Y., Su, C. C., Shao, S. C., Sung, S. F., Lin, S. J., Yang, Y. H. K. & Lai, E. C. C., 2019 Jan 1, In : Clinical Epidemiology. 11, p. 349-358 10 p.

Research output: Contribution to journalReview article

Open Access
National Health Programs
Databases
Research
Health
Information Storage and Retrieval
5 Citations (Scopus)

The Chang Gung Research Database—A multi-institutional electronic medical records database for real-world epidemiological studies in Taiwan

Shao, S. C., Chan, Y. Y., Kao Yang, Y. H., Lin, S. J., Hung, M. J., Chien, R. N., Lai, C. C. & Lai, E. C. C., 2019 May, In : Pharmacoepidemiology and drug safety. 28, 5, p. 593-600 8 p.

Research output: Contribution to journalArticle

Electronic Health Records
Taiwan
Epidemiologic Studies
Databases
Research

Use of hydrochlorothiazide and risk of skin cancer: a nationwide Taiwanese case–control study

Pottegård, A., Pedersen, S. A., Schmidt, S. A. J., Lee, C. N., Hsu, C. K., Liao, T. C., Shao, S. C. & Lai, E. C. C., 2019 Nov 26, In : British Journal of Cancer. 121, 11, p. 973-978 6 p.

Research output: Contribution to journalArticle

Hydrochlorothiazide
Skin Neoplasms
Lip Neoplasms
Melanoma
Odds Ratio
2018
2 Citations (Scopus)

Applying a common data model to asian databases for multinational pharmacoepidemiologic studies: Opportunities and challenges

Lai, E. C. C., Ryan, P., Zhang, Y., Schuemie, M., Hardy, N. C., Kamijima, Y., Kimura, S., Kubota, K., Man, K. K. C., Cho, S. Y., Park, R. W., Stang, P., Su, C. C., Wong, I. C. K., Kao, Y. H. Y. & Setoguchi, S., 2018 Jan 1, In : Clinical Epidemiology. 10, p. 875-885 11 p.

Research output: Contribution to journalArticle

RxNorm
Databases
Terminology
Pharmacoepidemiology
Pharmaceutical Preparations

Comparative safety of NSAIDs for gastrointestinal events in Asia-Pacific populations: A multi-database, international cohort study

Lai, E. C. C., Shin, J. Y., Kubota, K., Man, K. K. C., Park, B. J., Pratt, N., Roughead, E. E., Wong, I. C. K., Kao Yang, Y. H. & Setoguchi, S., 2018 Nov, In : Pharmacoepidemiology and drug safety. 27, 11, p. 1223-1230 8 p.

Research output: Contribution to journalArticle

Gastrointestinal Agents
Korea
Mefenamic Acid
Cohort Studies
Anti-Inflammatory Agents
3 Citations (Scopus)

Disease and economic burden for rare diseases in Taiwan: A longitudinal study using Taiwan’s National Health Insurance Research Database

Hsu, J. C., Wu, H. C., Feng, W. C., Chou, C. H., Lai, E. C. C. & Lu, C. Y., 2018 Sep, In : PloS one. 13, 9, e0204206.

Research output: Contribution to journalArticle

Health insurance
health care costs
health insurance
Cost of Illness
National Health Programs
1 Citation (Scopus)

Fractures and the increased risk of suicide: A population-based case-control study

Chang, C. F., Lai, E. C. C. & Yeh, M. K., 2018 Jun, In : Bone and Joint Journal. 100B, 6, p. 780-786 7 p.

Research output: Contribution to journalArticle

Suicide
Case-Control Studies
Population
Odds Ratio
Confidence Intervals
2 Citations (Scopus)

Look-Alike Medication Packages and Patient Safety

Shao, S. C., Lai, E., Owang, K. L., Chen, H. Y. & Chan, Y. Y., 2018 Sep 1, In : Journal of Patient Safety. 14, 3, p. e47-e48

Research output: Contribution to journalArticle

Product Packaging
Patient Safety
Medication Errors
Pharmacists
Industry
1 Citation (Scopus)

Methotrexate-induced pancytopenia in a patient with ectopic pregnancy

Shao, S. C., Yang, Y. H. K., Chien, P. S. & Lai, E. C. C., 2018 Mar, In : Archives of Medical Science. 14, 2, p. 475-476 2 p.

Research output: Contribution to journalLetter

Pancytopenia
Ectopic Pregnancy
Methotrexate

Penetration of new antidiabetic medications in East Asian countries and the United States: A cross-national comparative study

Kubota, K., Kamijima, Y., Yang, Y. H. K., Kimura, S., Lai, E. C. C., Man, K. K. C., Ryan, P., Schuemie, M., Stang, P., Su, C. C., Wong, I. C. K., Zhang, Y. & Setoguchi, S., 2018 Dec, In : PloS one. 13, 12, e0208796.

Research output: Contribution to journalArticle

hypoglycemic agents
Dipeptidyl-Peptidase IV Inhibitors
Hong Kong
East Asia
Hypoglycemic Agents

Subdural hemorrhage in patients with end-stage renal disease requiring dialysis: A single-center study

Hsieh, C. Y., Lai, E., Lee, J-S. & Tseng, C-C., 2018 Jan 1, In : Acta Neurologica Taiwanica. 27, 1, p. 9-17 9 p.

Research output: Contribution to journalArticle

Subdural Hematoma
Chronic Kidney Failure
Dialysis
Peritoneal Dialysis
Renal Dialysis

Therapeutic Duplication of Long-Acting Injectable Drugs

Shao, S. C., Lai, E., Chan, Y. Y., Hung, M. J. & Chen, H. Y., 2018 Sep 1, In : Journal of Patient Safety. 14, 3, p. e74-e75

Research output: Contribution to journalArticle

Medical Informatics
Patient Harm
Medication Errors
Injections
Hypocalcemia
21 Citations (Scopus)

Trends in attention-deficit hyperactivity disorder medication use: a retrospective observational study using population-based databases

Raman, S. R., Man, K. K. C., Bahmanyar, S., Berard, A., Bilder, S., Boukhris, T., Bushnell, G., Crystal, S., Furu, K., KaoYang, Y. H., Karlstad, Ø., Kieler, H., Kubota, K., Lai, E. C. C., Martikainen, J. E., Maura, G., Moore, N., Montero, D., Nakamura, H., Neumann, A. & 13 others, Pate, V., Pottegård, A., Pratt, N. L., Roughead, E. E., Macias Saint-Gerons, D., Stürmer, T., Su, C. C., Zoega, H., Sturkenbroom, M. C. J. M., Chan, E. W., Coghill, D., Ip, P. & Wong, I. C. K., 2018 Oct, In : The Lancet Psychiatry. 5, 10, p. 824-835 12 p.

Research output: Contribution to journalArticle

Attention Deficit Disorder with Hyperactivity
Observational Studies
Retrospective Studies
Databases
Population
2017
1 Citation (Scopus)

Potential contribution of lifestyle and socioeconomic factors to healthy user bias in antihypertensives and lipidlowering drugs

Kinjo, M., Lai, E. C. C., Korhonen, M. J., McGill, R. L. & Setoguchi, S., 2017 Mar 1, In : Open Heart. 4, 1, e000417.

Research output: Contribution to journalArticle

Antihypertensive Agents
Life Style
Lipids
Drug Users
Pharmaceutical Preparations
1 Citation (Scopus)

Previously undiagnosed risk factors and medication nonadherence are prevalent in young adults with first-ever stroke

Sung, S. F., Lai, E. C. C., Wu, D. P. & Hsieh, C. Y., 2017 Dec, In : Pharmacoepidemiology and drug safety. 26, 12, p. 1458-1464 7 p.

Research output: Contribution to journalArticle

Medication Adherence
Young Adult
Stroke
Hypertension
Hyperlipidemias
17 Citations (Scopus)

Sequence symmetry analysis in pharmacovigilance and pharmacoepidemiologic studies

Lai, E. C. C., Pratt, N., Hsieh, C. Y., Lin, S. J., Pottegård, A., Roughead, E. E., Kao Yang, Y. H. & Hallas, J., 2017 Jul 1, In : European Journal of Epidemiology. 32, 7, p. 567-582 16 p.

Research output: Contribution to journalReview article

Pharmacovigilance
Sequence Analysis
Pharmaceutical Preparations
Validation Studies
Drug-Related Side Effects and Adverse Reactions
2016
10 Citations (Scopus)

A comparison of stroke severity proxy measures for claims data research: A population-based cohort study

Sung, S. F., Chen, S. C. C., Hsieh, C. Y., Li, C. Y., Lai, E. C. C. & Hu, Y. H., 2016 Apr 1, In : Pharmacoepidemiology and drug safety. 25, 4, p. 438-443 6 p.

Research output: Contribution to journalArticle

Proxy
Cohort Studies
Stroke
Research
Population
3 Citations (Scopus)

Comparative persistence of antiepileptic drugs in patients with epilepsy: A STROBE-compliant retrospective cohort study

Lai, E. C. C., Hsieh, C. Y., Su, C. C., Yang, Y. H. K., Huang, C. W., Lin, S. J. & Setoguchi, S., 2016 Jan 1, In : Medicine (United States). 95, 35, e4481.

Research output: Contribution to journalArticle

Anticonvulsants
Epilepsy
Cohort Studies
Carbamazepine
Retrospective Studies
3 Citations (Scopus)

Comparative risk of oral ulcerations among antipsychotics users - population-based retrospective cohort study

Lai, E., Hsieh, C. Y., Wong, M. B., Lin, S. J., Yang, Y. K., Kao, Y-H. & Setoguchi, S., 2016 Feb 1, In : Pharmacoepidemiology and Drug Safety. 25, 2, p. 123-132 10 p.

Research output: Contribution to journalArticle

olanzapine
Antipsychotic Agents
Cohort Studies
Retrospective Studies
Sulpiride
19 Citations (Scopus)
Pharmaceutical Services
Medical problems
Type 2 Diabetes Mellitus
Randomized Controlled Trials
Pharmacists
13 Citations (Scopus)

Proton pump inhibitors and risk of Clostridium difficile infection: a multi-country study using sequence symmetry analysis

Roughead, E. E., Chan, E. W., Choi, N. K., Griffiths, J., Jin, X. M., Lee, J., Kimura, M., Kimura, T., Kubota, K., Lai, E. C. C., Man, K. K. C., Nguyen, T. A., Ooba, N., Park, B. J., Sato, T., Shin, J. Y., Wang, T. T., Wong, I. C. K., Yang, Y. H. K. & Pratt, N. L., 2016 Dec 1, In : Expert Opinion on Drug Safety. 15, 12, p. 1589-1595 7 p.

Research output: Contribution to journalArticle

Clostridium Infections
Clostridium difficile
Proton Pump Inhibitors
Sequence Analysis
Japan
2 Citations (Scopus)

Quetiapine-induced absence seizures in a dementia patient

Shao, S. C., Wu, W. H., Yang, Y. H. K. & Lai, E. C. C., 2016 Oct 1, In : Geriatrics and Gerontology International. 16, 10, p. 1168-1171 4 p.

Research output: Contribution to journalLetter

Severity of Illness Index
Absence Epilepsy
seizure
Valproic Acid
Phenytoin

Response to Iraqi and Hughes

Lai, E., Wong, M. B., Iwata, I., Zhang, Y., Hsieh, C. Y., Kao, Y-H. & Setoguchi, S., 2016 Jan 1, In : Journal of the American Geriatrics Society. 64, 1, p. 242-243 2 p.

Research output: Contribution to journalLetter

Indans
Phenylcarbamates
Piperidines
Galantamine
Cholinesterase Inhibitors
19 Citations (Scopus)

Use of the landmark method to address immortal person-time bias in comparative effectiveness research: a simulation study

Mi, X., Hammill, B. G., Curtis, L. H., Lai, E. & Setoguchi, S., 2016 Nov 20, In : Statistics in Medicine. 35, 26, p. 4824-4836 13 p.

Research output: Contribution to journalArticle

Comparative Effectiveness Research
Landmarks
Person
Simulation Study
Treatment Effects
2015
7 Citations (Scopus)

Comparative adherence to oral hormonal agents in older women with breast cancer

Cheung, W. Y., Lai, E., Ruan, J. Y., Chang, J. T. & Setoguchi, S., 2015 Jun 13, In : Breast Cancer Research and Treatment. 152, 2, p. 419-427 9 p.

Research output: Contribution to journalArticle

exemestane
letrozole
Tamoxifen
Breast Neoplasms
Compliance
21 Citations (Scopus)

Databases in the Asia-pacific region: The potential for a distributed network approach

Lai, E. C. C., Man, K. K. C., Chaiyakunapruk, N., Cheng, C. L., Chien, H. C., Chui, C. S. L., Dilokthornsakul, P., Hardy, N. C., Hsieh, C. Y., Hsu, C. Y., Kubota, K., Lin, T. C., Liu, Y., Park, B. J., Pratt, N., Roughead, E. E., Shin, J. Y., Watcharathanakij, S., Wen, J., Wong, I. C. K. & 3 others, Yang, Y. H. K., Zhang, Y. & Setoguchi, S., 2015 Oct 1, In : Epidemiology. 26, 6, p. 815-820 6 p.

Research output: Contribution to journalArticle

Databases
Electronic Health Records
Taiwan
Pharmacoepidemiology
Research Personnel
6 Citations (Scopus)
Multicenter Studies
Observational Studies
Stroke
Kidney
Multivariate Analysis
4 Citations (Scopus)
Factual Databases
National Health Programs
Kidney Diseases
International Classification of Diseases
Taiwan
Antipsychotic Agents
Safety
19 Citations (Scopus)

Prescription sequence symmetry analysis: Assessing risk, temporality, and consistency for adverse drug reactions across datasets in five countries

Pratt, N., Chan, E. W., Choi, N. K., Kimura, M., Kimura, T., Kubota, K., Lai, E. C. C., Man, K. K. C., Ooba, N., Park, B. J., Sato, T., Shin, J. Y., Wong, I. C. K., Kao Yang, Y. H. & Roughead, E. E., 2015 Aug 1, In : Pharmacoepidemiology and drug safety. 24, 8, p. 858-864 7 p.

Research output: Contribution to journalArticle

Amiodarone
Drug-Related Side Effects and Adverse Reactions
Prescriptions
Sequence Analysis
Thyroxine
7 Citations (Scopus)

Risk of pneumonia in new users of cholinesterase inhibitors for dementia

Lai, E., Wong, M. B., Iwata, I., Zhang, Y., Hsieh, C. Y., Kao, Y-H. & Setoguchi, S., 2015 May 1, In : Journal of the American Geriatrics Society. 63, 5, p. 869-876 8 p.

Research output: Contribution to journalArticle

Rivastigmine
Cholinesterase Inhibitors
Dementia
Pneumonia
Galantamine
13 Citations (Scopus)

Variation in Association Between Thiazolidinediones and Heart Failure Across Ethnic Groups: Retrospective analysis of Large Healthcare Claims Databases in Six Countries

Roughead, E. E., Chan, E. W., Choi, N. K., Kimura, M., Kimura, T., Kubota, K., Lai, E. C. C., Man, K. K. C., Nguyen, T. A., Ooba, N., Park, B. J., Sato, T., Shin, J. Y., Wang, T. T., Griffiths, J., Wong, I. C. K., Yang, Y. H. K. & Pratt, N. L., 2015 Sep 13, In : Drug Safety. 38, 9, p. 823-831 9 p.

Research output: Contribution to journalArticle

Thiazolidinediones
Ethnic Groups
Heart Failure
rosiglitazone
pioglitazone
2014
5 Citations (Scopus)

Chronic kidney disease and stroke

Hsieh, C. Y., Lin, H. J., Chen, C-H., Lai, E. & Kao, Y-H., 2014 Nov 1, In : The Lancet Neurology. 13, 11, 1 p.

Research output: Contribution to journalLetter

Cerebrovascular Disorders
Chronic Renal Insufficiency
Stroke
4 Citations (Scopus)

Complication rate of neurogenic lower urinary tract dysfunction after spinal cord injury in Taiwan

Lai, E. C. C., Kao Yang, Y. H. & Kuo, H. C., 2014 Jun, In : International Urology and Nephrology. 46, 6, p. 1063-1071 9 p.

Research output: Contribution to journalArticle

Urinary Tract
Spinal Cord Injuries
Taiwan
Urinary Catheterization
Length of Stay
8 Citations (Scopus)

Detecting potential adverse reactions of sulpiride in schizophrenic patients by prescription sequence symmetry analysis

Lai, E., Hsieh, C. Y., Kao, Y-H. & Lin, S. J., 2014 Feb 27, In : PloS one. 9, 2, e89795.

Research output: Contribution to journalArticle

Sulpiride
haloperidol
Prescriptions
Sequence Analysis
sequence analysis
9 Citations (Scopus)

Efforts to reduce the door-to-needle time of thrombolysis in acute ischemic stroke: Video-assisted therapeutic risk communication

Hsieh, C. Y., Chen, W. F., Chen, C-H., Wang, C. Y., Chen, C. J., Lai, E. & Chen, T. S., 2014 Dec 1, In : Journal of the Formosan Medical Association. 113, 12, p. 929-933 5 p.

Research output: Contribution to journalArticle

Needles
Stroke
Communication
Tissue Plasminogen Activator
Therapeutics
12 Citations (Scopus)

Is renal dysfunction associated with adverse stroke outcome after thrombolytic therapy?

Hsieh, C. Y., Lin, H. J., Sung, S. F., Hsieh, H. C., Lai, E. C. C. & Chen, C. H., 2014 Jan 1, In : Cerebrovascular Diseases. 37, 1, p. 51-56 6 p.

Research output: Contribution to journalArticle

Thrombolytic Therapy
Stroke
Kidney
Cerebral Hemorrhage
Glomerular Filtration Rate
2013
17 Citations (Scopus)

Comparative stroke risk of antiepileptic drugs in patients with epilepsy

Hsieh, C. Y., Lai, E., Kao, Y-H. & Lin, S. J., 2013 Jan 1, In : Epilepsia. 54, 1, p. 172-180 9 p.

Research output: Contribution to journalArticle

Anticonvulsants
Epilepsy
Stroke
Phenytoin
Carbamazepine
12 Citations (Scopus)

Effectiveness of sulpiride in adult patients with schizophrenia

Lai, E. C. C., Chang, C. H., Yang, Y. H. K., Lin, S. J. & Lin, C. Y., 2013 May 1, In : Schizophrenia bulletin. 39, 3, p. 673-683 11 p.

Research output: Contribution to journalArticle

olanzapine
Sulpiride
Antipsychotic Agents
Schizophrenia
Risperidone
28 Citations (Scopus)

Multi-country rapid adverse drug event assessment: The Asian Pharmacoepidemiology Network (AsPEN) antipsychotic and acute hyperglycaemia study

Pratt, N., Andersen, M., Bergman, U., Choi, N. K., Gerhard, T., Huang, C., Kimura, M., Kimura, T., Kubota, K., Lai, E. C. C., Ooba, N., Ösby, U., Park, B. J., Sato, T., Shin, J. Y., Sundström, A., Yang, Y. H. K. & Roughead, E. E., 2013 Sep 1, In : Pharmacoepidemiology and drug safety. 22, 9, p. 915-924 10 p.

Research output: Contribution to journalArticle

Pharmacoepidemiology
Drug-Related Side Effects and Adverse Reactions
Hyperglycemia
Antipsychotic Agents
olanzapine
32 Citations (Scopus)

The asian pharmacoepidemiology network (AsPEN): Promoting multi-national collaboration for pharmacoepidemiologic research in Asia

Andersen, M., Bergman, U., Choi, N. K., Gerhard, T., Huang, C., Jalbert, J., Kimura, M., Kimura, T., Kubota, K., Lai, E. C. C., Ooba, N., Park, B. J., Pratt, N., Roughead, E. E., Sato, T., Setoguchi, S., Shin, J. Y., Sundström, A. & Yang, Y. H. K., 2013 Jul 1, In : Pharmacoepidemiology and drug safety. 22, 7, p. 700-704 5 p.

Research output: Contribution to journalComment/debate

Factual Databases
Adverse Drug Reaction Reporting Systems
Drug Utilization Review
Pharmacoepidemiology
Pharmacovigilance
19 Citations (Scopus)

Use of antiepileptic drugs and risk of hypothyroidism

Lai, E., Kao, Y-H., Lin, S. J. & Hsieh, C. Y., 2013 Oct 1, In : Pharmacoepidemiology and Drug Safety. 22, 10, p. 1071-1079 9 p.

Research output: Contribution to journalArticle

Hypothyroidism
Thyroxine
Anticonvulsants
Phenytoin
Amiodarone