• 3464 Citations
  • 35 h-Index
1989 …2020
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Research Output 1989 2019

2019

Dengue virus nonstructural protein 1 activates platelets via Toll-like receptor 4, leading to thrombocytopenia and hemorrhage

Chao, C. H., Wu, W. C., Lai, Y. C., Tsai, P. J., Perng, G-C., Lin, Y. S. & Yeh, T-M., 2019 Apr 1, In : PLoS pathogens. 15, 4, p. e1007625

Research output: Contribution to journalArticle

Open Access
Dengue Virus
Toll-Like Receptor 4
Thrombocytopenia
Blood Platelets
Hemorrhage

Identification and characterization of permissive cells to dengue virus infection in human hematopoietic stem and progenitor cells

Hsu, A. Y., Ho, T. C., Lai, M. L., Tan, S. S., Chen, T-Y., Lee, M., Chien, Y-W., Chen, Y-P. & Perng, G-C., 2019 Sep 1, In : Transfusion. 59, 9, p. 2938-2951 14 p.

Research output: Contribution to journalArticle

Dengue Virus
Virus Diseases
Hematopoietic Stem Cells
Bone Marrow
Hematopoietic Stem Cell Transplantation

Seroepidemiology of dengue virus infection among adults during the ending phase of a severe dengue epidemic in southern Taiwan, 2015

Chien, Y-W., Huang, H. M., Ho, T. C., Tseng, F. C., Ko, N-Y., Ko, W-C. & Perng, G-C., 2019 Apr 24, In : BMC Infectious Diseases. 19, 1, 338.

Research output: Contribution to journalArticle

Open Access
Severe Dengue
Dengue Virus
Virus Diseases
Taiwan
Dengue

Seroprevalence of zika and dengue virus antibodies among migrant workers, taiwan, 2017

Perng, G-C., Ho, T. C., Shih, H-I., Lee, C. H., Huang, P. W., Chung, C. H., Ko, N-Y., Ko, W-C. & Chien, Y-W., 2019 Apr 1, In : Emerging infectious diseases. 25, 4, p. 814-816 3 p.

Research output: Contribution to journalArticle

Open Access
Southeastern Asia
Dengue Virus
Seroepidemiologic Studies
Taiwan
Antibodies
2018
1 Citation (Scopus)

Human glucose-regulated protein 78 modulates intracellular production and secretion of nonstructural protein 1 of dengue virus

Songprakhon, P., Limjindaporn, T., Perng, G-C., Puttikhunt, C., Thaingtamtanha, T., Dechtawewat, T., Saitornuang, S., Uthaipibull, C., Thongsima, S., Yenchitsomanus, P. T., Malasit, P. & Noisakran, S., 2018 Oct 1, In : Journal of General Virology. 99, 10, p. 1391-1406 16 p., 001134.

Research output: Contribution to journalArticle

Dengue Virus
Proteins
Binding Sites
Viruses
glucose-regulated proteins
3 Citations (Scopus)

Macrophage migration inhibitory factor is critical for dengue NS1-induced endothelial glycocalyx degradation and hyperpermeability

Chen, H. R., Chao, C. H., Liu, C-C., Ho, T-S., Tsai, H. P., Perng, G-C., Lin, Y-S., Wang, J-R. & Yeh, T-M., 2018 Apr 1, In : PLoS pathogens. 14, 4, e1007033.

Research output: Contribution to journalArticle

Macrophage Migration-Inhibitory Factors
Glycocalyx
Dengue
Metalloproteases
Proteins
3 Citations (Scopus)

Minocycline suppresses dengue virus replication by down-regulation of macrophage migration inhibitory factor-induced autophagy

Lai, Y. C., Chuang, Y. C., Chang, C-P., Lin, Y-S., Perng, G-C., Wu, H. C., Hsieh, S. L. & Yeh, T-M., 2018 Jul 1, In : Antiviral Research. 155, p. 28-38 11 p.

Research output: Contribution to journalArticle

Macrophage Migration-Inhibitory Factors
Dengue Virus
Minocycline
Autophagy
Virus Replication
4 Citations (Scopus)

Prolonged persistence of IgM against dengue virus detected by commonly used commercial assays

Chien, Y-W., Liu, Z. H., Tseng, F. C., Ho, T. C., Guo, H-R., Ko, N-Y., Ko, W-C. & Perng, G-C., 2018 Apr 2, In : BMC Infectious Diseases. 18, 1, 156.

Research output: Contribution to journalArticle

Dengue Virus
Immunoglobulin M
Dengue
Enzyme-Linked Immunosorbent Assay
Taiwan
2017
14 Citations (Scopus)

A bead-based immunofluorescence-assay on a microfluidic dielectrophoresis platform for rapid dengue virus detection

Iswardy, E., Tsai, T. C., Chang, H-C., Ho, T. C., Perng, G-C. & Chang, H. C., 2017 Sep 15, In : Biosensors and Bioelectronics. 95, p. 174-180 7 p.

Research output: Contribution to journalArticle

Dengue Virus
Microfluidics
Electrophoresis
Viruses
Fluorescent Antibody Technique

Could inactivation of platelets be key to preventing thrombocytopenia in dengue virus infected patients?

Lo, Y-C., Chien, Y-W. & Perng, G-C., 2017 Jul 1, In : Future Virology. 12, 7, p. 321-323 3 p.

Research output: Contribution to journalReview article

4 Citations (Scopus)
Dengue
Viremia
Blood Donors
Taiwan
Dengue Virus
3 Citations (Scopus)
Dengue
Taiwan
Disease Outbreaks
Odds Ratio
Intensive Care Units
2016
12 Citations (Scopus)

Autophagy-associated dengue vesicles promote viral transmission avoiding antibody neutralization

Wu, Y. W., Mettling, C., Wu, S-R., Yu, C. Y., Perng, G-C., Lin, Y-S. & Lin, Y. L., 2016 Aug 25, In : Scientific reports. 6, 32243.

Research output: Contribution to journalArticle

Dengue
Autophagy
Neutralizing Antibodies
Viral RNA
Antibodies
4 Citations (Scopus)

Characterization of dengue virus 2 growth in megakaryocyte-erythrocyte progenitor cells

Clark, K. B., Hsiao, H. M., Bassit, L., Crowe, J. E., Schinazi, R. F., Perng, G-C. & Villinger, F., 2016 Jun 1, In : Virology. 493, p. 162-172 11 p.

Research output: Contribution to journalArticle

Megakaryocyte-Erythroid Progenitor Cells
Megakaryocyte Progenitor Cells
Dengue Virus
Growth
Megakaryocytes
8 Citations (Scopus)

Confocal Microscopic Analysis of a Rabbit Eye Model of High-Incidence Recurrent Herpes Stromal Keratitis

Jester, J. V., Morishige, N., BenMohamed, L., Brown, D. J., Osorio, N., Hsiang, C., Perng, G-C., Jones, C. & Wechsler, S. L., 2016 Jan 1, In : Cornea. 35, 1, p. 81-88 8 p.

Research output: Contribution to journalArticle

Keratitis
Rabbits
Incidence
Human Herpesvirus 1
Confocal Microscopy
28 Citations (Scopus)
Macrophage Migration-Inhibitory Factors
Dengue Virus
Severe Dengue
Autophagy
Blood Vessels
6 Citations (Scopus)

Large Amounts of Reactivated Virus in Tears Precedes Recurrent Herpes Stromal Keratitis in Stressed Rabbits Latently Infected with Herpes Simplex Virus

Perng, G-C., Osorio, N., Jiang, X., Geertsema, R., Hsiang, C., Brown, D., Benmohamed, L. & Wechsler, S. L., 2016 Mar 3, In : Current Eye Research. 41, 3, p. 284-291 8 p.

Research output: Contribution to journalArticle

Herpetic Keratitis
Keratitis
Simplexvirus
Tears
Human Herpesvirus 1
1 Citation (Scopus)

Novel concept on antiviral strategies to dengue

Lo, Y-C. & Perng, G-C., 2016 Jun 1, In : Current Opinion in Virology. 18, p. 97-108 12 p.

Research output: Contribution to journalReview article

Dengue
Antiviral Agents
Dengue Virus
Confounding Factors (Epidemiology)
Virus Diseases
1 Citation (Scopus)

Varicella zoster virus infection of human fetal lung cells alters mitochondrial morphology

Keller, A. C., Badani, H., McClatchey, P. M., Baird, N. L., Bowlin, J. L., Bouchard, R., Perng, G-C., Reusch, J. E. B., Kaufer, B. B., Gilden, D., Shahzad, A., Kennedy, P. G. E. & Cohrs, R. J., 2016 Oct 1, In : Journal of NeuroVirology. 22, 5, p. 674-682 9 p.

Research output: Contribution to journalArticle

Human Herpesvirus 3
Virus Diseases
Immediate-Early Proteins
Lung
Mitochondria
2015
40 Citations (Scopus)

Biomarkers of severe dengue disease - A review

John, D. V., Lin, Y-S. & Perng, G-C., 2015 Oct 14, In : Journal of biomedical science. 22, 1, 191.

Research output: Contribution to journalReview article

Severe Dengue
Endothelial cells
Biomarkers
Chemical activation
Cytokines
7 Citations (Scopus)

Current neurological observations and complications of dengue virus infection

Solbrig, M. V. & Perng, G-C., 2015 Jun 1, In : Current Neurology and Neuroscience Reports. 15, 6, p. 1-8 8 p.

Research output: Contribution to journalReview article

Dengue Virus
Dengue
Virus Diseases
Flavivirus
Explosions
7 Citations (Scopus)

Infectious dengue vesicles derived from CD61+ cells in acute patient plasma exhibited a diaphanous appearance

Hsu, A. Y. H., Wu, S-R., Tsai, J. J., Chen, P-L., Chen, Y-P., Chen, T-Y., Lo, Y-C., Ho, T. C., Lee, M., Chen, M. T., Chiu, Y. C. & Perng, G-C., 2015 Dec 11, In : Scientific reports. 5, 17990.

Research output: Contribution to journalArticle

Dengue
Dengue Virus
Vero Cells
Virion
Dengue Vaccines
2014
80 Citations (Scopus)

Dengue virus infection induces expansion of a CD14 + CD16 + monocyte population that stimulates plasmablast differentiation

Kwissa, M., Nakaya, H. I., Onlamoon, N., Wrammert, J., Villinger, F., Perng, G-C., Yoksan, S., Pattanapanyasat, K., Chokephaibulkit, K., Ahmed, R. & Pulendran, B., 2014 Jul 9, In : Cell Host and Microbe. 16, 1, p. 115-127 13 p.

Research output: Contribution to journalArticle

Dengue Virus
Virus Diseases
Monocytes
Population
Dengue
94 Citations (Scopus)

Multi-peaked adaptive landscape for chikungunya virus evolution predicts continued fitness optimization in Aedes albopictus mosquitoes

Tsetsarkin, K. A., Chen, R., Yun, R., Rossi, S. L., Plante, K. S., Guerbois, M., Forrester, N., Perng, G-C., Sreekumar, E., Leal, G., Huang, J., Mukhopadhyay, S. & Weaver, S. C., 2014 Jun 16, In : Nature communications. 5, 4084.

Research output: Contribution to journalArticle

Chikungunya virus
fitness
Aedes
viruses
mutations
30 Citations (Scopus)

Neuropathogenesis of Japanese Encephalitis in a Primate Model

Myint, K. S. A., Kipar, A., Jarman, R. G., Gibbons, R. V., Perng, G-C., Flanagan, B., Mongkolsirichaikul, D., Van Gessel, Y. & Solomon, T., 2014 Aug 7, In : PLoS neglected tropical diseases. 8, 8, e2980.

Research output: Contribution to journalArticle

Japanese Encephalitis
Astrocytes
Primates
Neurons
Virus Diseases
6 Citations (Scopus)

Tranylcypromine reduces herpes simplex virus 1 infection in mice

Yao, H. W., Lin, P. H., Shen, F. H., Perng, G-C., Tung, Y-Y., Hsu, S-M. & Chen, S., 2014 Jan 1, In : Antimicrobial Agents and Chemotherapy. 58, 5, p. 2807-2815 9 p.

Research output: Contribution to journalArticle

Tranylcypromine
Human Herpesvirus 1
Virus Diseases
Acyclovir
Blindness
2013
14 Citations (Scopus)

Challenges for the formulation of a universal vaccine against dengue

Chokephaibulkit, K. & Perng, G-C., 2013 Aug 1, In : Experimental Biology and Medicine. 238, 5, p. 566-578 13 p.

Research output: Contribution to journalReview article

Dengue Vaccines
Severe Dengue
Dengue
Vaccines
Immunity
5 Citations (Scopus)

Immunologic hypo- or non-responder in natural dengue virus infection

Perng, G-C. & Chokephaibulkit, K., 2013 Jun 5, In : Journal of biomedical science. 20, 1, 34.

Research output: Contribution to journalReview article

Dengue Virus
Dengue
Virus Diseases
Viruses
Severe Dengue
4 Citations (Scopus)

Mortality from septic shock in a dengue infected patient: a case report.

Tsai, J. J., Hsieh, M. H., Liu, L. T., Hsiao, H. M. & Perng, G-C., 2013 Jan 1, In : Unknown Journal. 44, 4, p. 623-629 7 p.

Research output: Contribution to journalArticle

Dengue
Septic Shock
Coinfection
Mortality
Enterococcus faecium

Pathogenic Parameters Derived from Activated Platelets in Dengue Patients

Tsai, J-J., Chen, P-C., Liu, L-T., Chang, K., Yao, J-H., Hsiao, H-M., Clark, K. B., Chen, Y. H., Hsu, A. Y-H. & Perng, G-C., 2013, In : Tropical Medicine & Surgery. 01, 05

Research output: Contribution to journalArticle

8 Citations (Scopus)

Role of cognitive parameters in dengue hemorrhagic fever and dengue shock syndrome

Tsai, J. J., Chokephaibulkit, K., Chen, P. C., Liu, L. T., Hsiao, H. M., Lo, Y-C. & Perng, G-C., 2013 Dec 5, In : Journal of biomedical science. 20, 1, 88.

Research output: Contribution to journalReview article

Geographical distribution
Severe Dengue
Dengue
Medical problems
Endotoxins

Viral hemorrhagic fevers

Perng, G-C. & Solbrig, M. V., 2013 Jan 1, Viral Infections of the Human Nervous System. Jackson, A. (ed.). p. 337-368 32 p. (Birkhauser Advances in Infectious Diseases).

Research output: Chapter in Book/Report/Conference proceedingChapter

Viral Hemorrhagic Fevers
Filoviridae
Arenaviridae
Bunyaviridae
Flaviviridae
2012
35 Citations (Scopus)

Infection of bone marrow cells by dengue virus invivo

Noisakran, S., Onlamoon, N., Hsiao, H. M., Clark, K. B., Villinger, F., Ansari, A. A. & Perng, G-C., 2012 Jan 1, In : Experimental Hematology. 40, 3

Research output: Contribution to journalArticle

Dengue Virus
Bone Marrow Cells
Infection
Bone Marrow
Virus Diseases
20 Citations (Scopus)

Multiploid CD61+ Cells Are the Pre-Dominant Cell Lineage Infected during Acute Dengue Virus Infection in Bone Marrow

Clark, K. B., Noisakran, S., Onlamoon, N., Hsiao, H. M., Roback, J., Villinger, F., Ansari, A. A. & Perng, G-C., 2012 Dec 27, In : PloS one. 7, 12, e52902.

Research output: Contribution to journalArticle

Dengue virus
Dengue Virus
Cell Lineage
Virus Diseases
Viruses
101 Citations (Scopus)

Rapid and massive virus-specific plasmablast responses during acute: Dengue virus infection in humans

Wrammert, J., Onlamoon, N., Akondy, R. S., Perng, G-C., Polsrila, K., Chandele, A., Kwissa, M., Pulendran, B., Wilson, P. C., Wittawatmongkol, O., Yoksan, S., Angkasekwinai, N., Pattanapanyasat, K., Chokephaibulkit, K. & Ahmed, R., 2012 Mar 1, In : Journal of Virology. 86, 6, p. 2911-2918 8 p.

Research output: Contribution to journalArticle

Dengue virus
Dengue Virus
Virus Diseases
immunopathology
Viruses
17 Citations (Scopus)

Role of CD61 + cells in thrombocytopenia of dengue patients

Noisakran, S., Onlamoon, N., Pattanapanyasat, K., Hsiao, H. M., Songprakhon, P., Angkasekwinai, N., Chokephaibulkit, K., Villinger, F., Ansari, A. A. & Perng, G-C., 2012 Nov 1, In : International Journal of Hematology. 96, 5, p. 600-610 11 p.

Research output: Contribution to journalArticle

Dengue Virus
Dengue
Thrombocytopenia
Macaca mulatta
Blood Platelets
8 Citations (Scopus)

Role of microparticles in dengue virus infection and its impact on medical intervention strategies

Clark, K. B., Hsiao, H. M., Noisakran, S., Tsai, J. J. & Perng, G-C., 2012 Mar 1, In : Yale Journal of Biology and Medicine. 85, 1, p. 3-18 16 p.

Research output: Contribution to journalArticle

Dengue Virus
Virus Diseases
Viruses
Dengue
Life Cycle Stages
15 Citations (Scopus)

The importance of hematopoietic progenitor cells in dengue

Tsai, J. J., Liu, L. T., Chang, K., Wang, S. H., Hsiao, H. M., Clark, K. B. & Perng, G-C., 2012 Jan 1, In : Therapeutic Advances in Hematology. 3, 1, p. 59-71 13 p.

Research output: Contribution to journalReview article

Dengue
Hematopoietic Stem Cells
Bone Marrow
Disease Progression
Patient Care
2011
26 Citations (Scopus)

Frequency alterations in key innate immune cell components in the peripheral blood of dengue patients detected by FACS analysis

Tsai, J. J., Jen, Y. H., Chang, J. S., Hsiao, H. M., Noisakran, S. & Perng, G-C., 2011 Aug 1, In : Journal of Innate Immunity. 3, 5, p. 530-540 11 p.

Research output: Contribution to journalArticle

Dengue
Cellular Structures
Blood Platelets
Monocytes
Leukocytes
2010
35 Citations (Scopus)

Cells in dengue virus infection in vivo

Noisakran, S., Onlamoon, N., Songprakhon, P., Hsiao, H. M., Chokephaibulkit, K. & Perng, G-C., 2010 Dec 1, In : Advances in Virology. 2010, 164878.

Research output: Contribution to journalReview article

Severe Dengue
Dengue Virus
Virus Diseases
Dengue
Viremia
97 Citations (Scopus)

Dengue virus - Induced hemorrhage in a nonhuman primate model

Onlamoon, N., Noisakran, S., Hsiao, H. M., Duncan, A., Villinger, F., Ansari, A. A. & Perng, G-C., 2010 Mar 4, In : Blood. 115, 9, p. 1823-1834 12 p.

Research output: Contribution to journalArticle

Dengue Virus
Viruses
Dengue
Primates
Hemorrhage

Role of infection in neurologic and psychiatric diseases

Solbrig, M. V. & Perng, G-C., 2010 Aug 13, In : Interdisciplinary Perspectives on Infectious Diseases. 2010, 645834.

Research output: Contribution to journalEditorial

Nervous System Diseases
Psychiatry
Infection
61 Citations (Scopus)

Towards an understanding of the herpes simplex virus type 1 latency-reactivation cycle

Jones, C. & Perng, G-C., 2010 Apr 22, In : Interdisciplinary Perspectives on Infectious Diseases. 2010, 262415.

Research output: Contribution to journalReview article

Virus Latency
Human Herpesvirus 1
Trigeminal Ganglion
Viral Genes
Peripheral Nervous System
2009
36 Citations (Scopus)

A re-evaluation of the mechanisms leading to dengue hemorrhagic fever

Noisakran, S., Chokephaibulkit, K., Songprakhon, P., Onlamoon, N., Hsiao, H. M., Villinger, F., Ansari, A. & Perng, G-C., 2009 Jan 1, In : Annals of the New York Academy of Sciences. 1171, SUPPL. 1

Research output: Contribution to journalReview article

Severe Dengue
Dengue Virus
Viruses
Dengue
Viremia
51 Citations (Scopus)

Detection of dengue virus in platelets isolated from dengue patients

Noisakran, S., Gibbons, R. V., Songprakhon, P., Jairungsri, A., Ajariyakhajorn, C., Nisalak, A., Jarman, R. G., Malasit, P., Chokephaibulkit, K. & Perng, G-C., 2009 Mar 1, In : Southeast Asian Journal of Tropical Medicine and Public Health. 40, 2, p. 253-262 10 p.

Research output: Contribution to journalArticle

Dengue Virus
Dengue
Blood Platelets
Viral RNA
Virus Diseases
11 Citations (Scopus)

ICAM-5 modulates cytokine/chemokine production in the CNS during the course of herpes simplex virus type 1 infection

Tse, M. C. L., Lane, C., Mott, K., Onlamoon, N., Hsiao, H. M. & Perng, G-C., 2009 Aug 18, In : Journal of Neuroimmunology. 213, 1-2, p. 12-19 8 p.

Research output: Contribution to journalArticle

Cell Adhesion Molecules
Human Herpesvirus 1
Virus Diseases
Chemokines
Cytokines
9 Citations (Scopus)

Identification of a novel herpes simplex virus type 1 transcript and protein (AL3) expressed during latency

Jaber, T., Henderson, G., Li, S., Perng, G-C., Carpenter, D., Wechsler, S. L. & Jones, C., 2009 Nov 9, In : Journal of General Virology. 90, 10, p. 2342-2352 11 p.

Research output: Contribution to journalArticle

Human Herpesvirus 1
Open Reading Frames
Trigeminal Ganglion
Neuroblastoma
Proteins
2008
51 Citations (Scopus)

Alternate hypothesis on the pathogenesis of dengue hemorrhagic fever (DHF)/dengue shock syndrome (DSS) in dengue virus infection

Noisakran, S. & Perng, G-C., 2008 Apr 1, In : Experimental Biology and Medicine. 233, 4, p. 401-408 8 p.

Research output: Contribution to journalShort survey

Severe Dengue
Dengue Virus
Virus Diseases
Viruses
Public health

Evaluation of severity of HSV-1 corneal infection by statistical pattern classification technique

Shieh, Y. Y. & Perng, G-C., 2008 Dec 1, In : Current Eye Research. 33, 3, p. 225-235 11 p.

Research output: Contribution to journalArticle

Human Herpesvirus 1
Rabbits
Infection
Corneal Diseases
Photography
2007
37 Citations (Scopus)

A recombinant herpes simplex virus type 1 expressing two additional copies of gK is more pathogenic than wild-type virus in two different strains of mice

Mott, K. R., Perng, G-C., Osorio, Y., Kousoulas, K. G. & Ghiasi, H., 2007 Dec 1, In : Journal of Virology. 81, 23, p. 12962-12972 11 p.

Research output: Contribution to journalArticle

Human herpesvirus 1
Human Herpesvirus 1
glycoproteins
Glycoproteins
Viruses