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2020

Bile acid and bile acid transporters are involved in the pathogenesis of acute hepatopancreatic necrosis disease in white shrimp Litopenaeus vannamei

Kumar, R., Ng, T. H., Chang, C. C., Tung, T. C., Lin, S. S., Lo, C. F. & Wang, H. C., 2020 Jan 1, In : Cellular Microbiology. 22, 1, e13127.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Penaeus vannamei serine proteinase inhibitor 7 (LvSerpin7) acts as an immune brake by regulating the proPO system in AHPND-affected shrimp

Apitanyasai, K., Chang, C. C., Ng, T. H., Ng, Y. S., Liou, J. H., Lo, C. F., Lin, S. S. & Wang, H. C., 2020 May, In : Developmental and Comparative Immunology. 106, 103600.

Research output: Contribution to journalArticle

2019
Open Access

ICTV virus taxonomy profile: Nimaviridae

ICTV Report Consortium, 2019 Jul, In : Journal of General Virology. 100, 7, p. 1053-1054 2 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

LvRas and LvRap are both important for WSSV replication in Litopenaeus vannamei

Tseng, Y. T., Kumar, R. & Wang, H. C., 2019 May, In : Fish and Shellfish Immunology. 88, p. 150-160 11 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Selective expression of a “correct cloud” of Dscam in crayfish survivors after second exposure to the same pathogen

Ng, T. H., Kumar, R., Apitanyasai, K., He, S. T., Chiu, S. P. & Wang, H. C., 2019 Sep, In : Fish and Shellfish Immunology. 92, p. 430-437 8 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Structural insights to the heterotetrameric interaction between the vibrio parahaemolyticus pirAvp and pirBvp toxins and activation of the cry-like pore-forming domain

Lin, S. J., Chen, Y. F., Hsu, K. C., Chen, Y. L., Ko, T. P., Lo, C. F., Wang, H. C. & Wang, H. C., 2019 Apr, In : Toxins. 11, 4, 233.

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)

The gene structure and hypervariability of the complete Penaeus monodon Dscam gene

Apitanyasai, K., Huang, S. W., Ng, T. H., He, S. T., Huang, Y. H., Chiu, S. P., Tseng, K. C., Lin, S. S., Chang, W. C., Baldwin-Brown, J. G., Long, A. D., Lo, C. F., Yu, H. T. & Wang, H. C., 2019 Dec 1, In : Scientific reports. 9, 1, 16595.

Research output: Contribution to journalArticle

Open Access
2018
4 Citations (Scopus)

The Rho signalling pathway mediates the pathogenicity of AHPND-causing V. parahaemolyticus in shrimp

Ng, T. H., Lu, C. W., Lin, S. S., Chang, C. C., Tran, L. H., Chang, W. C., Lo, C. F. & Wang, H. C., 2018 Aug, In : Cellular Microbiology. 20, 8, e12849.

Research output: Contribution to journalArticle

7 Citations (Scopus)

What vaccination studies tell us about immunological memory within the innate immune system of cultured shrimp and crayfish

Chang, Y. H., Kumar, R., Ng, T. H. & Wang, H. C., 2018 Mar, In : Developmental and Comparative Immunology. 80, p. 53-66 14 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)
2017
2 Citations (Scopus)

Dscam1 in pancrustacean immunity: Current status and a look to the future

Armitage, S. A. O., Kurtz, J., Brites, D., Dong, Y., Pasquier, L. D. & Wang, H. C., 2017 Jun 9, In : Frontiers in Immunology. 8, JUN, 662.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Microbiome Dynamics in a Shrimp Grow-out Pond with Possible Outbreak of Acute Hepatopancreatic Necrosis Disease

Chen, W. Y., Ng, T. H., Wu, J. H., Chen, J. W. & Wang, H. C., 2017 Dec 1, In : Scientific reports. 7, 1, 9395.

Research output: Contribution to journalArticle

39 Citations (Scopus)

Resonant Dipolar Coupling of Microwaves with Confined Acoustic Vibrations in a Rod-shaped Virus

Sun, C. K., Tsai, Y. C., Chen, Y. J. E., Liu, T. M., Chen, H. Y., Wang, H. C. & Lo, C. F., 2017 Dec 1, In : Scientific reports. 7, 1, 4611.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Using CRISPR/Cas9-mediated gene editing to further explore growth and trade-off effects in myostatin-mutated F4 medaka (Oryzias latipes)

Yeh, Y. C., Kinoshita, M., Ng, T. H., Chang, Y. H., Maekawa, S., Chiang, Y. A., Aoki, T. & Wang, H. C., 2017 Dec 1, In : Scientific reports. 7, 1, 11435.

Research output: Contribution to journalArticle

8 Citations (Scopus)
2016

A member of the immunoglobulin superfamily, orange-spotted grouper novel immune gene EcVig, is induced by immune stimulants and type I interferon

Yeh, Y. C., Wang, T. Y., Chou, H. Y., Lin, H. Y., Chen, T. Y., Aoki, T. & Wang, H. C., 2016 Nov 1, In : Fish and Shellfish Immunology. 58, p. 415-422 8 p.

Research output: Contribution to journalArticle

Expression and biological activity of two types of interferon genes in medaka (Oryzias latipes)

Maekawa, S., Chiang, Y. A., Hikima, J. I., Sakai, M., Lo, C. F., Wang, H. C. & Aoki, T., 2016 Jan 1, In : Fish and Shellfish Immunology. 48, p. 20-29 10 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Replication of the shrimp virus WSSV depends on glutamate-driven anaplerosis

Li, C. Y., Wang, Y. J., Huang, S. W., Cheng, C. S. & Wang, H. C., 2016 Jan 11, In : PloS one. 11, 1, e0146902.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Six Hours after Infection, the Metabolic Changes Induced by WSSV Neutralize the Host's Oxidative Stress Defenses

Chen, I. T., Lee, D. Y., Huang, Y. T., Kou, G. H., Wang, H. C., Chang, G. D. & Lo, C. F., 2016 Jun 9, In : Scientific reports. 6, 27732.

Research output: Contribution to journalArticle

16 Citations (Scopus)

TALENs-mediated gene disruption of myostatin produces a larger phenotype of medaka with an apparently compromised immune system

Chiang, Y. A., Kinoshita, M., Maekawa, S., Kulkarni, A., Lo, C. F., Yoshiura, Y., Wang, H. C. & Aoki, T., 2016 Jan 1, In : Fish and Shellfish Immunology. 48, p. 212-220 9 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)
2015

A novel detection platform for shrimp white spot syndrome virus using an ICP11-dependent immunomagnetic reduction (IMR) assay

Liu, B. H., Lin, Y. C., Ho, C. S., Yang, C. C., Chang, Y. T., Chang, J. F., Li, C. Y., Cheng, C. S., Huang, J. Y., Lee, Y. F., Hsu, M. H., Lin, F. C., Wang, H. C., Lo, C. F., Yang, S. Y. & Wang, H. C., 2015 Sep 18, In : PLoS ONE. 10, 9, e0138207.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Pathogenesis of acute hepatopancreatic necrosis disease (AHPND) in shrimp

Lai, H. C., Ng, T. H., Ando, M., Lee, C. T., Chen, I. T., Chuang, J. C., Mavichak, R., Chang, S. H., Yeh, M. D., Chiang, Y. A., Takeyama, H., Hamaguchi, H. O., Lo, C. F., Aoki, T. & Wang, H. C., 2015 Dec 1, In : Fish and Shellfish Immunology. 47, 2, p. 1006-1014 9 p.

Research output: Contribution to journalArticle

74 Citations (Scopus)

The DNA fibers of shrimp hemocyte extracellular traps are essential for the clearance of Escherichia coli

Ng, T. H., Wu, M. H., Chang, S. H., Aoki, T. & Wang, H. C., 2015 Jan 1, In : Developmental and Comparative Immunology. 48, 1, p. 229-233 5 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

The opportunistic marine pathogen Vibrio parahaemolyticus becomes virulent by acquiring a plasmid that expresses a deadly toxin

Lee, C. T., Chen, I. T., Yang, Y. T., Ko, T. P., Huang, Y. T., Huang, J. Y., Huang, M. F., Lin, S. J., Chen, C. Y., Lin, S. S., Lightner, D. V., Wang, H. C., Wang, A. H. J., Wang, H. C., Hor, L. I. & Lo, C. F., 2015 Aug 25, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 34, p. 10798-10803 6 p.

Research output: Contribution to journalArticle

177 Citations (Scopus)

To complete its replication cycle, a shrimp virus changes the population of long chain fatty acids during infection via the PI3K-Akt-mTOR-HIF1α pathway

Hsieh, Y. C., Chen, Y. M., Li, C. Y., Chang, Y. H., Liang, S. Y., Lin, S. Y., Lin, C. Y., Chang, S. H., Wang, Y. J., Khoo, K. H., Aoki, T. & Wang, H. C., 2015 Jan 1, In : Developmental and Comparative Immunology. 53, 1, p. 85-95 11 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)
2014

An Invertebrate Warburg Effect: A Shrimp Virus Achieves Successful Replication by Altering the Host Metabolome via the PI3K-Akt-mTOR Pathway

Su, M. A., Huang, Y. T., Chen, I. T., Lee, D. Y., Hsieh, Y. C., Li, C. Y., Ng, T. H., Liang, S. Y., Lin, S. Y., Huang, S. W., Chiang, Y. A., Yu, H. T., Khoo, K. H., Chang, G. D., Lo, C. F. & Wang, H. C., 2014 Jun, In : PLoS pathogens. 10, 6, e1004196.

Research output: Contribution to journalArticle

65 Citations (Scopus)

Draft genome sequences of four strains of Vibrio parahaemolyticus, three of which cause early mortality syndrome/acute hepatopancreatic necrosis disease in shrimp in China and Thailand

Yang, Y. T., Chen, I. T., Lee, C. T., Chen, C. Y., Lin, S. S., Hor, L. I., Tseng, T. C., Huang, Y. T., Sritunyalucksana, K., Thitamadee, S., Wang, H. C. & Lo, C. F., 2014 Jan 1, In : Genome Announcements. 2, 5, e00816-14.

Research output: Contribution to journalArticle

68 Citations (Scopus)

EcVig, a novel grouper immune-gene associated with antiviral activity against NNV infection

Yeh, Y. C., Hsu, Y. J., Chen, Y. M., Lin, H. Y., Yang, H. L., Chen, T. Y. & Wang, H. C., 2014 Mar 1, In : Developmental and Comparative Immunology. 43, 1, p. 68-75 8 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Validation of a commercial insulated isothermal PCR-based POCKIT test for rapid and easy detection of white spot syndrome virus infection in Litopenaeus vannamei

Tsai, Y. L., Wang, H. C., Lo, C. F., Tang-Nelson, K., Lightner, D., Ou, B. R., Hour, A. L., Tsai, C. F., Yen, C. C., Chang, H. F. G., Teng, P. H. & Lee, P. Y., 2014 Mar 13, In : PloS one. 9, 3, e90545.

Research output: Contribution to journalArticle

29 Citations (Scopus)

WSSV-induced crayfish Dscam shows durable immune behavior

Ng, T. H., Hung, H. Y., Chiang, Y. A., Lin, J. H., Chen, Y. N., Chuang, Y. C. & Wang, H. C., 2014 Sep, In : Fish and Shellfish Immunology. 40, 1, p. 78-90 13 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)
2013

Properties of Litopenaeus vannamei Dscam (LvDscam) isoforms relatedto specific pathogen recognition

Hung, H. Y., Ng, T. H., Lin, J. H., Chiang, Y. A., Chuang, Y. C. & Wang, H. C., 2013 Oct, In : Fish and Shellfish Immunology. 35, 4, p. 1272-1281 10 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

Shrimp Dscam and its cytoplasmic tail splicing activator serine/arginine (SR)-rich protein B52 were both induced after white spot syndrome virus challenge

Chiang, Y. A., Hung, H. Y., Lee, C. W., Huang, Y. T. & Wang, H-C., 2013 Jan 1, In : Fish and Shellfish Immunology. 34, 1, p. 209-219 11 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Shrimp hemocytes release extracellular traps that kill bacteria

Ng, T. H., Chang, S. H., Wu, M. H. & Wang, H-C., 2013 Dec 1, In : Developmental and Comparative Immunology. 41, 4, p. 644-651 8 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

The DNA virus white spot syndrome virus uses an internal ribosome entry site for translation of the highly expressed nonstructural protein ICP35

Kang, S. T., Wang, H. C., Yang, Y. T., Kou, G. H. & Lo, C. F., 2013 Dec 1, In : Journal of Virology. 87, 24, p. 13263-13278 16 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
2012

Feeding hermit crabs to shrimp broodstock increases their risk of WSSV infection

Chang, Y. S., Liu, W. J., Chen, T. C., Chan, T. Y., Liu, K. F., Chuang, J. C., Kou, G. H., Lo, C. F. & Wang, H. C., 2012 Apr 26, In : Diseases of Aquatic Organisms. 98, 3, p. 193-199 7 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Heterogeneous nuclear ribonucleoprotein hrp36 acts as an alternative splicing repressor in Litopenaeus vannamei Dscam

Lee, C. W., Chen, I. T., Chou, P. H., Hung, H. Y. & Wang, KC. H. C., 2012 Jan 1, In : Developmental and Comparative Immunology. 36, 1, p. 10-20 11 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Identification and characterization of DSCAM isoforms isolated from orange-spotted grouper Epinephelus coioides

Yeh, Y. C., Lee, C. W., Pan, Y. W., Hsu, Y. J., Hung, H. Y., Chen, Y. M., Lin, H. Y., Chen, T. Y., Yang, H. L. & Wang, H. C., 2012 Sep 1, In : Developmental and Comparative Immunology. 38, 1, p. 148-159 12 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Penaeus monodon thioredoxin restores the DNA binding activity of oxidized white spot syndrome virus IE1

Huang, J. Y., Liu, W. J., Wang, H. C., Lee, D. Y., Leu, J. H., Wang, H. C., Tsai, M. H., Kang, S. T., Chen, I. T., Kou, G. H., Chang, G. D. & Lo, C. F., 2012 Sep 15, In : Antioxidants and Redox Signaling. 17, 6, p. 914-926 13 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Spawning stress triggers WSSV replication in brooders via the activation of shrimp STAT

Lin, S. J., Hsia, H. L., Liu, W. J., Huang, J. Y., Liu, K. F., Chen, W. Y., Yeh, Y. C., Huang, Y. T., Lo, C. F., Kou, G. H. & Wang, H. C., 2012 Sep 1, In : Developmental and Comparative Immunology. 38, 1, p. 128-135 8 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)
2011

An oral nervous necrosis virus vaccine using Vibrio anguillarum as an expression host provides early protection

Chen, Y-M., Shih, C. H., Liu, H. C., Wu, C. L., Lin, C. C., Wang, H-C., Chen, T-Y., Yang, H. L. & Lin, J. H. Y., 2011 Nov 16, In : Aquaculture. 321, 1-2, p. 26-33 8 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Penaeus monodon Dscam (PmDscam) has a highly diverse cytoplasmic tail and is the first membrane-bound shrimp Dscam to be reported

Chou, P. H., Chang, H. S., Chen, I. T., Lee, C. W., Hung, H. Y. & Han-Ching Wang, K. C., 2011 Jan 1, In : Fish and Shellfish Immunology. 30, 4-5, p. 1109-1123 15 p.

Research output: Contribution to journalArticle

41 Citations (Scopus)

Penaeus monodon TATA box-binding protein interacts with the white spot syndrome virus transactivator IE1 and promotes its transcriptional activity

Liu, W. J., Chang, Y. S., Huang, W. T., Chen, I. T., Wang, K. C. H. C., Kou, G. H. & Lo, C. F., 2011 Jul 1, In : Journal of Virology. 85, 13, p. 6535-6547 13 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

The expression of two novel orange-spotted grouper (Epinephelus coioides) TNF genes in peripheral blood leukocytes, various organs, and fish larvae

Lam, F. W. S., Wu, S. Y., Lin, S. J., Lin, C. C., Chen, Y. M., Wang, H. C., Chen, T. Y., Lin, H. T. & Lin, J. H. Y., 2011 Feb, In : Fish and Shellfish Immunology. 30, 2, p. 618-629 12 p.

Research output: Contribution to journalArticle

57 Citations (Scopus)

White spot syndrome virus induces metabolic changes resembling the warburg effect in shrimp hemocytes in the early stage of infection

Chen, I. T., Aoki, T., Huang, Y. T., Hirono, I., Chen, T. C., Huang, J. Y., Chang, G. D., Lo, C. F. & Wang, H. C., 2011 Dec 1, In : Journal of Virology. 85, 24, p. 12919-12928 10 p.

Research output: Contribution to journalArticle

85 Citations (Scopus)
2010
96 Citations (Scopus)

The Marsupenaeus japonicus voltage-dependent anion channel (MjVDAC) protein is involved in white spot syndrome virus (WSSV) pathogenesis

Wang, H-C., Kondo, H., Hirono, I. & Aoki, T., 2010 Jan 1, In : Fish and Shellfish Immunology. 29, 1, p. 94-103 10 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)
2009

Polycistronic mRNAs and internal ribosome entry site elements (IRES) are widely used by white spot syndrome virus (WSSV) structural protein genes

Kang, S. T., Leu, J. H., Wang, H. C., Chen, L. L., Kou, G. H. & Lo, C. F., 2009 May 10, In : Virology. 387, 2, p. 353-363 11 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

The putative invertebrate adaptive immune protein Litopenaeus vannamei Dscam (LvDscam) is the first reported Dscam to lack a transmembrane domain and cytoplasmic tail

Chou, P. H., Chang, H. S., Chen, I. T., Lin, H. Y., Chen, Y. M., Yang, H. L. & Wang, K. C. H. C., 2009 Dec 1, In : Developmental and Comparative Immunology. 33, 12, p. 1258-1267 10 p.

Research output: Contribution to journalArticle

61 Citations (Scopus)
2008

White spot syndrome virus protein ICP11: A histone-binding DNA mimic that disrupts nucleosome assembly

Wang, H. C., Wang, H-C., Ko, T. P., Lee, Y. M., Leu, J. H., Ho, C. H., Huang, W. P., Lo, C-F. & Wang, A. H. J., 2008 Dec 30, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 52, p. 20758-20763 6 p.

Research output: Contribution to journalArticle

56 Citations (Scopus)