• 2328 Citations
  • 26 h-Index
19962019
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Research Output 1996 2019

2012
54 Citations (Scopus)

Role of the human high-affinity copper transporter in copper homeostasis regulation and cisplatin sensitivity in cancer chemotherapy

Kuo, M. T., Fu, S., Savaraj, N. & Chen, H. H. W., 2012 Sep 15, In : Cancer Research. 72, 18, p. 4616-4621 6 p.

Research output: Contribution to journalReview article

Cisplatin
Copper
Homeostasis
Drug Therapy
Neoplasms
2013
13 Citations (Scopus)

Estimating the lifelong health impact and financial burdens of different types of lung cancer

Yang, S. C., Lai, W. W., Su, W. C., Wu, S. Y., Chen, H. H. W., Wu, Y. L., Hung, M. C. & Wang, J. D., 2013 Dec 5, In : BMC cancer. 13, 579.

Research output: Contribution to journalArticle

Lung Neoplasms
Quality of Life
Life Expectancy
Health
Health Expenditures
66 Citations (Scopus)

Interleukin-17-producing cell infiltration in the breast cancer tumour microenvironment is a poor prognostic factor

Chen, W. C., Lai, Y. H., Chen, H. Y., Guo, H. R., Su, I. J. & Chen, H. H. W., 2013 Aug 1, In : Histopathology. 63, 2, p. 225-233 9 p.

Research output: Contribution to journalArticle

Tumor Microenvironment
Interleukin-17
Breast Neoplasms
Disease-Free Survival
Th17 Cells
57 Citations (Scopus)
STAT3 Transcription Factor
AMP-Activated Protein Kinases
Metformin
Cytotoxicity
Liver
16 Citations (Scopus)

Overcoming platinum drug resistance with copper-lowering agents

Chen, H. H. W. & Kuo, M. T., 2013 Oct 1, In : Anticancer Research. 33, 10, p. 4157-4162 6 p.

Research output: Contribution to journalArticle

Platinum
Drug Resistance
Copper
Drug Therapy
Carboplatin
5 Citations (Scopus)
Rectal Neoplasms
Neoplasms
Surgeons
Lymph Nodes
Anus Neoplasms
14 Citations (Scopus)
Fluorodeoxyglucose F18
Non-Small Cell Lung Carcinoma
Disease-Free Survival
Lung
Survival
6 Citations (Scopus)
Doppler Ultrasonography
Radiotherapy
Carcinoma
Recurrence
Biomarkers
2014
9 Citations (Scopus)
Life Expectancy
Lung Neoplasms
Quality of Life
Non-Small Cell Lung Carcinoma
Quality-Adjusted Life Years
7 Citations (Scopus)

Inhibiting glucosylceramide synthase facilitates the radiosensitizing effects of vinorelbine in lung adenocarcinoma cells

Chiu, W. H., Chen, H. H. W., Chang, J. Y., Luo, S. J., Li, C. L., Chen, C. L., Su, W. C. & Lin, C. F., 2014 Jul 28, In : Cancer Letters. 349, 2, p. 144-151 8 p.

Research output: Contribution to journalArticle

ceramide glucosyltransferase
Radiation-Sensitizing Agents
Chemoradiotherapy
JNK Mitogen-Activated Protein Kinases
Apoptosis
10 Citations (Scopus)

Regulation of the high-affinity copper transporter (hCtr1) expression by cisplatin and heavy metals

Liang, Z. D., Long, Y., Chen, H. H. W., Savaraj, N. & Kuo, M. T., 2014 Jan 14, In : Journal of Biological Inorganic Chemistry. 19, 1, p. 17-27 11 p.

Research output: Contribution to journalArticle

Heavy Metals
Cisplatin
Copper
Platinum
Pharmaceutical Preparations
2015
5 Citations (Scopus)
Life Expectancy
Quality of Life
Incidence
Health
Neoplasms
19 Citations (Scopus)

Targeting drug transport mechanisms for improving platinum-based cancer chemotherapy

Chen, H. H. W., Chen, W. C., Liang, Z. D., Tsai, W. B., Long, Y., Aiba, I., Fu, S., Broaddus, R., Liu, J., Feun, L. G., Savaraj, N. & Kuo, M. T., 2015 Oct 3, In : Expert Opinion on Therapeutic Targets. 19, 10, p. 1307-1317 11 p.

Research output: Contribution to journalReview article

Chemotherapy
Drug Delivery Systems
Platinum
Drug Therapy
Copper
2016
8 Citations (Scopus)

Cisplatin-induced synthetic lethality to arginine-starvation therapy by transcriptional suppression of ASS1 is regulated by DEC1, HIF-1α, and c-Myc transcription network and is independent of ASS1 promoter DNA methylation

Long, Y., Tsai, W. B., Chang, J. T., Estecio, M., Wangpaichitr, M., Savaraj, N., Feun, L. G., Chen, H. W. & Kuo, M. T., 2016 Jan 1, In : Oncotarget. 7, 50, p. 82658-82670 13 p.

Research output: Contribution to journalArticle

Argininosuccinate Synthase
DNA Methylation
Starvation
Cisplatin
Arginine
5 Citations (Scopus)
Taiwan
Cost-Benefit Analysis
Quality-Adjusted Life Years
Gross Domestic Product
Neoplasms
4 Citations (Scopus)
DNA-Binding Proteins
Platinum
Cisplatin
Copper
Homeostasis
2017
5 Citations (Scopus)

Argininosuccinate synthetase 1 (ASS1) is a common metabolic marker of chemosensitivity for targeted arginine- and glutamine-starvation therapy

Long, Y., Tsai, W. B., Wang, D., Hawke, D. H., Savaraj, N., Feun, L. G., Hung, M. C., Chen, H. H. W. & Kuo, M. T., 2017 Mar 1, In : Cancer Letters. 388, p. 54-63 10 p.

Research output: Contribution to journalArticle

Argininosuccinate Synthase
Starvation
Glutamine
Arginine
Therapeutics
2 Citations (Scopus)

Chromatin remodeling system p300-HDAC2-Sin3A is involved in Arginine Starvation-Induced HIF-1α Degradation at the ASS1 promoter for ASS1 Derepression

Tsai, W. B., Long, Y., Chang, J. T., Savaraj, N., Feun, L. G., Jung, M., Chen, H. H. W. & Kuo, M. T., 2017 Dec 1, In : Scientific reports. 7, 1, 10814.

Research output: Contribution to journalArticle

Argininosuccinate Synthase
Chromatin Assembly and Disassembly
Starvation
Arginine
Histones
23 Citations (Scopus)

Improving radiotherapy in cancer treatment: Promises and challenges

Chen, H. H. W. & Kuo, M. T., 2017 Sep 1, In : Oncotarget. 8, 37, p. 62742-62758 17 p.

Research output: Contribution to journalReview article

Radiotherapy
Neoplasms
Tumor Microenvironment
Radiation Tolerance
Therapeutics
3 Citations (Scopus)

Wheat germ agglutinin-induced paraptosis-like cell death and protective autophagy is mediated by autophagy-linked FYVE inhibition

Tsai, T. L., Wang, H. C., Hung, C. H., Lin, P. C., Lee, Y. S., Chen, H. H. W. & Su, W. C., 2017 Jan 1, In : Oncotarget. 8, 53, p. 91209-91222 14 p.

Research output: Contribution to journalArticle

Wheat Germ Agglutinins
Autophagy
Cell Death
HeLa Cells
Unfolded Protein Response
2018
3 Citations (Scopus)

Adjuvant radiotherapy after curative surgery for oral cavity squamous cell carcinoma and treatment effect of timing and duration on outcome—A Taiwan Cancer Registry national database analysis

Cheng, Y. J., Tsai, M. H., Chiang, C. J., Tsai, S. T., Liu, T. W., Lou, P. J., Liao, C. T., Lin, J. C., Chang, J. T. C., Tsai, M. H., Chu, P. Y., Leu, Y. S., Tsai, K. Y., Terng, S. D., Chien, C. Y., Yang, M. H., Hao, S. P., Wang, C. C., Tsai, M. H., Chen, H. H. W. & 2 others, Kuo, C. & Wu, Y. H., 2018 Jul, In : Cancer medicine. 7, 7, p. 3073-3083 11 p.

Research output: Contribution to journalArticle

Adjuvant Radiotherapy
Taiwan
Registries
Mouth
Squamous Cell Carcinoma
7 Citations (Scopus)
homeostasis
Drug and Narcotic Control
Platinum
Antineoplastic Agents
Tumors
2019
Open Access
Fluorodeoxyglucose F18
Non-Small Cell Lung Carcinoma
Glycolysis
Radiotherapy
Tumor Burden