• 2273 Citations
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19962019
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Research Output 1996 2019

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Article
2019
Open Access
Fluorodeoxyglucose F18
Non-Small Cell Lung Carcinoma
Glycolysis
Radiotherapy
Tumor Burden
2018
3 Citations (Scopus)

Adjuvant radiotherapy after curative surgery for oral cavity squamous cell carcinoma and treatment effect of timing and duration on outcome—A Taiwan Cancer Registry national database analysis

Cheng, Y-J., Tsai, M-H., Chiang, C. J., Tsai, S-T., Liu, T. W., Lou, P. J., Liao, C. T., Lin, J. C., Chang, J. T. C., Tsai, M. H., Chu, P. Y., Leu, Y. S., Tsai, K. Y., Terng, S. D., Chien, C. Y., Yang, M. H., Hao, S. P., Wang, C. C., Tsai, M. H., Chen, H. H. W. & 2 others, Kuo, C. & Wu, Y-H., 2018 Jul 1, In : Cancer medicine. 7, 7, p. 3073-3083 11 p.

Research output: Contribution to journalArticle

Adjuvant Radiotherapy
Taiwan
Registries
Mouth
Squamous Cell Carcinoma
2017
5 Citations (Scopus)

Argininosuccinate synthetase 1 (ASS1) is a common metabolic marker of chemosensitivity for targeted arginine- and glutamine-starvation therapy

Long, Y., Tsai, W. B., Wang, D., Hawke, D. H., Savaraj, N., Feun, L. G., Hung, M. C., Chen, H. H. W. & Kuo, M. T., 2017 Mar 1, In : Cancer Letters. 388, p. 54-63 10 p.

Research output: Contribution to journalArticle

Argininosuccinate Synthase
Starvation
Glutamine
Arginine
Therapeutics
1 Citation (Scopus)

Chromatin remodeling system p300-HDAC2-Sin3A is involved in Arginine Starvation-Induced HIF-1α Degradation at the ASS1 promoter for ASS1 Derepression

Tsai, W. B., Long, Y., Chang, J. T., Savaraj, N., Feun, L. G., Jung, M., Chen, H. H. W. & Kuo, M. T., 2017 Dec 1, In : Scientific reports. 7, 1, 10814.

Research output: Contribution to journalArticle

Argininosuccinate Synthase
Chromatin Assembly and Disassembly
Starvation
Arginine
Histones
3 Citations (Scopus)

Wheat germ agglutinin-induced paraptosis-like cell death and protective autophagy is mediated by autophagy-linked FYVE inhibition

Tsai, T. L., Wang, H. C., Hung, C. H., Lin, P-C., Lee, Y. S., Chen, H. H. W. & Su, W-C., 2017 Jan 1, In : Oncotarget. 8, 53, p. 91209-91222 14 p.

Research output: Contribution to journalArticle

Wheat Germ Agglutinins
Autophagy
Cell Death
HeLa Cells
Unfolded Protein Response
2016
8 Citations (Scopus)

Cisplatin-induced synthetic lethality to arginine-starvation therapy by transcriptional suppression of ASS1 is regulated by DEC1, HIF-1α, and c-Myc transcription network and is independent of ASS1 promoter DNA methylation

Long, Y., Tsai, W. B., Chang, J. T., Estecio, M., Wangpaichitr, M., Savaraj, N., Feun, L. G., Chen, H. H. W. & Kuo, M. T., 2016 Jan 1, In : Oncotarget. 7, 50, p. 82658-82670 13 p.

Research output: Contribution to journalArticle

Argininosuccinate Synthase
DNA Methylation
Starvation
Cisplatin
Arginine
5 Citations (Scopus)

Cost effectiveness of cancer treatment in Taiwan

Hung, M. C., Lai, W-W., Chen, H. H. W., Lee, J-C., Lin, Y-J., Hsiao, J-R., Cheng, Y-M., Shan, Y-S., Su, W-C. & Wang, J-D., 2016 Aug 1, In : Journal of the Formosan Medical Association. 115, 8, p. 609-618 10 p.

Research output: Contribution to journalArticle

Taiwan
Cost-Benefit Analysis
Quality-Adjusted Life Years
Gross Domestic Product
Neoplasms
4 Citations (Scopus)
DNA-Binding Proteins
Platinum
Cisplatin
Copper
Homeostasis
2015
5 Citations (Scopus)
Life Expectancy
Quality of Life
Incidence
Health
Neoplasms
2014
9 Citations (Scopus)
Life Expectancy
Lung Neoplasms
Quality of Life
Non-Small Cell Lung Carcinoma
Quality-Adjusted Life Years
7 Citations (Scopus)

Inhibiting glucosylceramide synthase facilitates the radiosensitizing effects of vinorelbine in lung adenocarcinoma cells

Chiu, W-H., Chen, H. H. W., Chang, J-Y., Luo, S. J., Li, C. L., Chen, C. L., Su, W-C. & Lin, C. F., 2014 Jul 28, In : Cancer Letters. 349, 2, p. 144-151 8 p.

Research output: Contribution to journalArticle

ceramide glucosyltransferase
Radiation-Sensitizing Agents
Chemoradiotherapy
JNK Mitogen-Activated Protein Kinases
Apoptosis
10 Citations (Scopus)

Regulation of the high-affinity copper transporter (hCtr1) expression by cisplatin and heavy metals

Liang, Z. D., Long, Y., Chen, H. H. W., Savaraj, N. & Kuo, M. T., 2014 Jan 14, In : Journal of Biological Inorganic Chemistry. 19, 1, p. 17-27 11 p.

Research output: Contribution to journalArticle

Heavy Metals
Cisplatin
Copper
Platinum
Pharmaceutical Preparations
2013
13 Citations (Scopus)

Estimating the lifelong health impact and financial burdens of different types of lung cancer

Yang, S-C., Lai, W-W., Su, W-C., Wu, S-Y., Chen, H. H. W., Wu, Y. L., Hung, M. C. & Wang, J-D., 2013 Dec 5, In : BMC cancer. 13, 579.

Research output: Contribution to journalArticle

Lung Neoplasms
Quality of Life
Life Expectancy
Health
Health Expenditures
66 Citations (Scopus)

Interleukin-17-producing cell infiltration in the breast cancer tumour microenvironment is a poor prognostic factor

Chen, W. C., Lai, Y-H., Chen, H. Y., Guo, H-R., Su, I. J. & Chen, H. H. W., 2013 Aug 1, In : Histopathology. 63, 2, p. 225-233 9 p.

Research output: Contribution to journalArticle

Tumor Microenvironment
Interleukin-17
Breast Neoplasms
Disease-Free Survival
Th17 Cells
54 Citations (Scopus)
STAT3 Transcription Factor
AMP-Activated Protein Kinases
Metformin
Cytotoxicity
Liver
15 Citations (Scopus)

Overcoming platinum drug resistance with copper-lowering agents

Chen, H. H. W. & Kuo, M. T., 2013 Oct 1, In : Anticancer Research. 33, 10, p. 4157-4162 6 p.

Research output: Contribution to journalArticle

Platinum
Drug Resistance
Copper
Drug Therapy
Carboplatin
5 Citations (Scopus)
Rectal Neoplasms
Neoplasms
Surgeons
Lymph Nodes
Anus Neoplasms
14 Citations (Scopus)
Fluorodeoxyglucose F18
Non-Small Cell Lung Carcinoma
Disease-Free Survival
Lung
Survival
6 Citations (Scopus)
Doppler Ultrasonography
Radiotherapy
Carcinoma
Recurrence
Biomarkers
2012
4 Citations (Scopus)

Bone marrow transplantation enhances trafficking of host-derived myelomonocytic cells that rescue intestinal mucosa after whole body radiation

Ch'Ang, H. J., Lin, L. M., Chang, P. Y., Luo, C. W., Chang, Y. H., Chou, C. K. & Chen, H. H. W., 2012 Sep 1, In : Radiotherapy and Oncology. 104, 3, p. 401-407 7 p.

Research output: Contribution to journalArticle

Whole-Body Irradiation
Intestinal Mucosa
Bone Marrow Transplantation
Intestines
Transplantation
6 Citations (Scopus)
Uterine Cervical Neoplasms
radiation therapy
Radiotherapy
cancer
activation
13 Citations (Scopus)
Intensity-Modulated Radiotherapy
Mouth
Squamous Cell Carcinoma
Radiotherapy
Survival Rate
44 Citations (Scopus)

Mechanistic basis for overcoming platinum resistance using copper chelating agents

Liang, Z. D., Long, Y., Tsai, W. B., Fu, S., Kurzrock, R., Gagea-Iurascu, M., Zhang, F., Chen, H. H. W., Hennessy, B. T., Mills, G. B., Savaraj, N. & Kuo, M. T., 2012 Nov 1, In : Molecular Cancer Therapeutics. 11, 11, p. 2483-2494 12 p.

Research output: Contribution to journalArticle

Chelating Agents
Platinum
Copper
Drug Resistance
Ovarian Neoplasms
19 Citations (Scopus)

Mitochondrial uncoupling protein 2 regulates the effects of paclitaxel on Stat3 activation and cellular survival in lung cancer cells

Su, W-P., Lo Ya-Chin, C., Yan, J. J., Liao, I-C., Tsai, P-J., Wang, H. C., Yeh, H. H., Lin, C-C., Chen, H. H. W., Lai, W-W. & Su, W-C., 2012 Nov 1, In : Carcinogenesis. 33, 11, p. 2065-2075 11 p.

Research output: Contribution to journalArticle

Paclitaxel
Lung Neoplasms
Survival
Reactive Oxygen Species
Drug Therapy
49 Citations (Scopus)
Platinum
Non-Small Cell Lung Carcinoma
Drug Therapy
Disease-Free Survival
Copper
137 Citations (Scopus)
Glycolysis
Non-Small Cell Lung Carcinoma
Tumor Burden
Disease-Free Survival
Lung
2011
12 Citations (Scopus)
STAT3 Transcription Factor
Estrogen Receptors
Up-Regulation
Lung Neoplasms
Epidermal Growth Factor Receptor
2010
30 Citations (Scopus)

Hypothyroidism After Radiotherapy for Nasopharyngeal Cancer Patients

Wu, Y-H., Wang, H. M., Chen, H. H. W., Lin, C. Y., Chen, E. Y. C., Fan, K. H., Huang, S. F., Chen, I. H., Liao, C. T., Cheng, A. J. & Chang, J. T. C., 2010 Mar 15, In : International Journal of Radiation Oncology Biology Physics. 76, 4, p. 1133-1139 7 p.

Research output: Contribution to journalArticle

Nasopharyngeal Neoplasms
Hypothyroidism
radiation therapy
Radiotherapy
cancer
10 Citations (Scopus)

Isolated osteoradionecrosis of the dens mimicking metastasis of nasopharyngeal carcinoma after radiotherapy

Lee, J-S., Huang, C. M., Yeh, I. C., Chen, H. H. W., Lin, J. C. & Chen, H. H., 2010 Aug 1, In : Journal of Clinical Neuroscience. 17, 8, p. 1064-1066 3 p.

Research output: Contribution to journalArticle

Osteoradionecrosis
Radiotherapy
Neoplasm Metastasis
Spine
Nasopharynx
7 Citations (Scopus)

Single cell phospho-specific flow cytometry can detect dynamic changes of phospho-Stat1 level in lung cancer cells

Lin, C-C., Huang, W. L., Su, W-P., Chen, H. H. W., Lai, W-W., Yan, J. J. & Su, W-C., 2010 Nov 1, In : Cytometry Part A. 77, 11, p. 1008-1019 12 p.

Research output: Contribution to journalArticle

Lung Neoplasms
Flow Cytometry
Neoplasms
Malignant Pleural Effusion
Cisplatin
2009
7 Citations (Scopus)

Neurophysiological and histopathological evaluation of low-dose radiation on the cauda equina and postlaminotomy fibrosis: An experimental study in the rat

Su, W-R., Lee, J-S., Chen, H. H. W., Wang, L-C., Huang, Y. H., Jung, Y. C. & Jou, I. M., 2009 Mar 1, In : Spine. 34, 5, p. 463-469 7 p.

Research output: Contribution to journalArticle

Cauda Equina
Fibrosis
Radiation
Somatosensory Evoked Potentials
Radiotherapy
2008
52 Citations (Scopus)

Elevated glutathione levels confer cellular sensitization to cisplatin toxicity by up-regulation of copper transporter hCtr1

Chen, H. H. W., Song, I. S., Hossain, A., Choi, M. K., Yamane, Y., Liang, Z. D., Lu, J., Wu, L. Y. H., Siddik, Z. H., Klomp, L. W. J., Savaraj, N. & Kuo, M. T., 2008 Sep 1, In : Molecular Pharmacology. 74, 3, p. 697-704 8 p.

Research output: Contribution to journalArticle

Cisplatin
Glutathione
Copper
Up-Regulation
Glutamate-Cysteine Ligase
165 Citations (Scopus)
Gold
Nanoparticles
Electrons
Neoplasms
Melanoma
52 Citations (Scopus)

Transcription factor Sp1 plays an important role in the regulation of copper homeostasis in mammalian cells

Song, I. S., Chen, H. H. W., Aiba, I., Hossain, A., Liang, Z. D., Klomp, L. W. J. & Kuo, M. T., 2008 Sep 1, In : Molecular Pharmacology. 74, 3, p. 705-713 9 p.

Research output: Contribution to journalArticle

Sp1 Transcription Factor
Copper
Homeostasis
Messenger RNA
Poisons
2007
49 Citations (Scopus)

Hypoxia-inducible factor-1α correlates with MET and metastasis in node-negative breast cancer

Chen, H. H. W., Su, W-C., Lin, P. W., Guo, H-R. & Lee, W. Y., 2007 Jun 1, In : Breast Cancer Research and Treatment. 103, 2, p. 167-175 9 p.

Research output: Contribution to journalArticle

Hypoxia-Inducible Factor 1
Breast Neoplasms
Neoplasm Metastasis
Disease-Free Survival
Survival Rate
31 Citations (Scopus)

IGF-1 upregulates electroneutral K-Cl cotransporter KCC3 and KCC4 which are differentially required for breast cancer cell proliferation and invasiveness

Hsu, Y. M., Chou, C-Y., Chen, H. H. W., Lee, W. Y., Chen, Y. F., Lin, P. W., Alper, S. L., Ellory, J. C. & Shen, M-R., 2007 Mar 1, In : Journal of Cellular Physiology. 210, 3, p. 626-636 11 p.

Research output: Contribution to journalArticle

Cell proliferation
Somatomedins
Up-Regulation
Cell Proliferation
Breast Neoplasms
2006
150 Citations (Scopus)

Autocrine IL-6-induced Stat3 activation contributes to the pathogenesis of lung adenocarcinoma and malignant pleural effusion

Yeh, H. H., Lai, W. W., Chen, H. H. W., Liu, H. S. & Su, W. C., 2006 Jul 20, In : Oncogene. 25, 31, p. 4300-4309 10 p.

Research output: Contribution to journalArticle

Malignant Pleural Effusion
Interleukin-6
Vascular Endothelial Growth Factor A
Lung Neoplasms
Adenocarcinoma of lung
15 Citations (Scopus)
Genetic Promoter Regions
Single Nucleotide Polymorphism
Tumor Necrosis Factor-alpha
Genes
Alleles
25 Citations (Scopus)
acceleration (physics)
radiation therapy
Radiotherapy
cancer
Neck
9 Citations (Scopus)
peritoneum
Doppler Ultrasonography
Papillary Carcinoma
Peritoneum
tumors
2005
10 Citations (Scopus)

Allelic loss of 14q32 in the pathogenesis of gastrointestinal and ampullary malignancies: Mapping of the target region to a 17 cM interval

Dai, Y. C., Ho, C-L., Tsai, Y. C., Hsu, Y. H., Chang, Y. C., Liu, H-S., Chen, H. H. W. & Chow, N-H., 2005 Feb 1, In : Journal of Cancer Research and Clinical Oncology. 131, 2, p. 94-100 7 p.

Research output: Contribution to journalArticle

Loss of Heterozygosity
Carcinoma
Neoplasms
Microsatellite Repeats
Stomach Neoplasms
30 Citations (Scopus)
Natural Killer T-Cells
T-Cell Lymphoma
Nose
In Situ Hybridization
Bone Marrow
104 Citations (Scopus)

Co-expression of RON and MET is a prognostic indicator for patients with transitional-cell carcinoma of the bladder

Cheng, H-L., Liu, H-S., Lin, Y-J., Chen, H. H. W., Hsu, P. Y., Chang, T. Y., Ho, C-L., Tzai, T. S. & Chow, N-H., 2005 May 23, In : British Journal of Cancer. 92, 10, p. 1906-1914 9 p.

Research output: Contribution to journalArticle

Transitional Cell Carcinoma
Urinary Bladder
Urinary Bladder Neoplasms
Proto-Oncogene Proteins c-met
RON protein
46 Citations (Scopus)
Nitric Oxide Synthase Type II
Cyclooxygenase 2
nitric oxide
Nitric Oxide Synthase
Uterine Cervical Neoplasms
112 Citations (Scopus)

Prognostic significance of co-expression of RON and MET receptors in node-negative breast cancer patients

Lee, W. Y., Chen, H. H. W., Chow, N-H., Su, W-C., Lin, P. W. & Guo, H-R., 2005 Mar 15, In : Clinical Cancer Research. 11, 6, p. 2222-2228 7 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Odds Ratio
Neoplasms
Cell Line
rice bran saccharide
2004
4 Citations (Scopus)

Ethmoid sinus cancer: Results of treatment with surgery and combined therapy

Lin, C-Y., Chen, H. H. W., Chen, H. H., Fang, S-Y. & Tsai, S-T., 2004 Dec 1, In : Acta Oto-Laryngologica. 124, 10, p. 1220-1225 6 p.

Research output: Contribution to journalArticle

Ethmoid Sinus
Neoplasms
Neoplasm Metastasis
Therapeutics
Neck
75 Citations (Scopus)

Expression of S100A4 and Met: Potential Predictors for Metastasis and Survival in Early-Stage Breast Cancer

Lee, W. Y., Su, W-C., Lin, P. W., Guo, H-R., Chang, T. W. & Chen, H. H. W., 2004 Oct 27, In : Oncology. 66, 6, p. 429-438 10 p.

Research output: Contribution to journalArticle

Disease-Free Survival
Breast Neoplasms
Neoplasm Metastasis
Survival
Neoplasms
66 Citations (Scopus)
Hepatocellular Carcinoma
Tumor Necrosis Factor-alpha
Alleles
Genes
Hepatitis C
15 Citations (Scopus)

Prognostic implications of Fas-ligand expression in nasopharyngeal carcinoma

Ho, S. Y., Guo, H-R., Chen, H. H. W., Hsiao, J-R., Jin, Y. T. & Tsai, S-T., 2004 Nov 1, In : Head and Neck. 26, 11, p. 977-983 7 p.

Research output: Contribution to journalArticle

Fas Ligand Protein
Disease-Free Survival
Neoplasms
Survival
Neoplasm Staging
2003
53 Citations (Scopus)

A phase II trial of gemcitabine in the treatment of advanced bile duct and periampullary carcinomas

Lin, M. H., Chen, J. S., Chen, H. H. W. & Su, W-C., 2003 Jun 30, In : Chemotherapy. 49, 3, p. 154-158 5 p.

Research output: Contribution to journalArticle

gemcitabine
Bile Ducts
Carcinoma
Therapeutics
Confidence Intervals