• 2311 Citations
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19962019
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Research Output 1996 2019

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Article
Article
12 Citations (Scopus)
STAT3 Transcription Factor
Estrogen Receptors
Up-Regulation
Lung Neoplasms
Epidermal Growth Factor Receptor
3 Citations (Scopus)

Adjuvant radiotherapy after curative surgery for oral cavity squamous cell carcinoma and treatment effect of timing and duration on outcome—A Taiwan Cancer Registry national database analysis

Cheng, Y-J., Tsai, M-H., Chiang, C. J., Tsai, S-T., Liu, T. W., Lou, P. J., Liao, C. T., Lin, J. C., Chang, J. T. C., Tsai, M. H., Chu, P. Y., Leu, Y. S., Tsai, K. Y., Terng, S. D., Chien, C. Y., Yang, M. H., Hao, S. P., Wang, C. C., Tsai, M. H., Chen, H. H. W. & 2 others, Kuo, C. & Wu, Y-H., 2018 Jul 1, In : Cancer medicine. 7, 7, p. 3073-3083 11 p.

Research output: Contribution to journalArticle

Adjuvant Radiotherapy
Taiwan
Registries
Mouth
Squamous Cell Carcinoma
10 Citations (Scopus)

Allelic loss of 14q32 in the pathogenesis of gastrointestinal and ampullary malignancies: Mapping of the target region to a 17 cM interval

Dai, Y. C., Ho, C-L., Tsai, Y. C., Hsu, Y. H., Chang, Y. C., Liu, H-S., Chen, H. H. W. & Chow, N-H., 2005 Feb 1, In : Journal of Cancer Research and Clinical Oncology. 131, 2, p. 94-100 7 p.

Research output: Contribution to journalArticle

Loss of Heterozygosity
Carcinoma
Neoplasms
Microsatellite Repeats
Stomach Neoplasms
53 Citations (Scopus)

A phase II trial of gemcitabine in the treatment of advanced bile duct and periampullary carcinomas

Lin, M. H., Chen, J. S., Chen, H. H. W. & Su, W-C., 2003 Jun 30, In : Chemotherapy. 49, 3, p. 154-158 5 p.

Research output: Contribution to journalArticle

gemcitabine
Bile Ducts
Carcinoma
Therapeutics
Confidence Intervals
5 Citations (Scopus)

Argininosuccinate synthetase 1 (ASS1) is a common metabolic marker of chemosensitivity for targeted arginine- and glutamine-starvation therapy

Long, Y., Tsai, W. B., Wang, D., Hawke, D. H., Savaraj, N., Feun, L. G., Hung, M. C., Chen, H. H. W. & Kuo, M. T., 2017 Mar 1, In : Cancer Letters. 388, p. 54-63 10 p.

Research output: Contribution to journalArticle

Argininosuccinate Synthase
Starvation
Glutamine
Arginine
Therapeutics
153 Citations (Scopus)

Autocrine IL-6-induced Stat3 activation contributes to the pathogenesis of lung adenocarcinoma and malignant pleural effusion

Yeh, H. H., Lai, W. W., Chen, H. H. W., Liu, H. S. & Su, W. C., 2006 Jul 20, In : Oncogene. 25, 31, p. 4300-4309 10 p.

Research output: Contribution to journalArticle

Malignant Pleural Effusion
Interleukin-6
Vascular Endothelial Growth Factor A
Lung Neoplasms
Adenocarcinoma of lung
30 Citations (Scopus)
Natural Killer T-Cells
T-Cell Lymphoma
Nose
In Situ Hybridization
Bone Marrow
4 Citations (Scopus)

Bone marrow transplantation enhances trafficking of host-derived myelomonocytic cells that rescue intestinal mucosa after whole body radiation

Ch'Ang, H. J., Lin, L. M., Chang, P. Y., Luo, C. W., Chang, Y. H., Chou, C. K. & Chen, H. H., 2012 Sep 1, In : Radiotherapy and Oncology. 104, 3, p. 401-407 7 p.

Research output: Contribution to journalArticle

Whole-Body Irradiation
Intestinal Mucosa
Bone Marrow Transplantation
Intestines
Transplantation
21 Citations (Scopus)

Changes in bone mineral density of lumbar spine after pelvic radiotherapy

Chen, H. H. W., Lee, B-F., Guo, H-R., Su, W-R. & Chiu, N-T., 2002 Apr 17, In : Radiotherapy and Oncology. 62, 2, p. 239-242 4 p.

Research output: Contribution to journalArticle

Bone Density
Spine
Radiotherapy
Uterine Cervical Neoplasms
Therapeutics
1 Citation (Scopus)

Chromatin remodeling system p300-HDAC2-Sin3A is involved in Arginine Starvation-Induced HIF-1α Degradation at the ASS1 promoter for ASS1 Derepression

Tsai, W. B., Long, Y., Chang, J. T., Savaraj, N., Feun, L. G., Jung, M., Chen, H. H. W. & Kuo, M. T., 2017 Dec 1, In : Scientific reports. 7, 1, 10814.

Research output: Contribution to journalArticle

Argininosuccinate Synthase
Chromatin Assembly and Disassembly
Starvation
Arginine
Histones
8 Citations (Scopus)

Cisplatin-induced synthetic lethality to arginine-starvation therapy by transcriptional suppression of ASS1 is regulated by DEC1, HIF-1α, and c-Myc transcription network and is independent of ASS1 promoter DNA methylation

Long, Y., Tsai, W. B., Chang, J. T., Estecio, M., Wangpaichitr, M., Savaraj, N., Feun, L. G., Chen, H. W. & Kuo, M. T., 2016 Jan 1, In : Oncotarget. 7, 50, p. 82658-82670 13 p.

Research output: Contribution to journalArticle

Argininosuccinate Synthase
DNA Methylation
Starvation
Cisplatin
Arginine
28 Citations (Scopus)

Clinical evaluation of HER-2/neu protein in malignant pleural effusion-associated lung adenocarcinoma and as a tumor marker in pleural effusion diagnosis

Hung, T. L., Chen, F. F., Liu, J. M., Lai, W-W., Hsiao, A. L., Huang, W. T., Chen, H. H. W. & Su, W-C., 2003 Jul 1, In : Clinical Cancer Research. 9, 7, p. 2605-2612 8 p.

Research output: Contribution to journalArticle

Malignant Pleural Effusion
Pleural Effusion
Tumor Biomarkers
Lung Neoplasms
Proteins
14 Citations (Scopus)
Ribs
Breast Neoplasms
Neoplasm Metastasis
Bone and Bones
Confidence Intervals
19 Citations (Scopus)

Clinical significance of allelotype profiling for urothelial carcinoma

Tzai, T. S., Chen, H. H. W., Chan, S-H., Ho, C-L., Tsai, Y-S., Cheng, H-L., Dai, Y. C., Lin, J. S. N., Yang, W-H. & Chow, N-H., 2003 Aug 1, In : Urology. 62, 2, p. 378-384 7 p.

Research output: Contribution to journalArticle

Loss of Heterozygosity
Carcinoma
Carcinogenesis
Chromosomes
Survival
13 Citations (Scopus)
Ribs
Bone and Bones
Neoplasms
Neoplasm Metastasis
Chi-Square Distribution
104 Citations (Scopus)

Co-expression of RON and MET is a prognostic indicator for patients with transitional-cell carcinoma of the bladder

Cheng, H-L., Liu, H-S., Lin, Y-J., Chen, H. H. W., Hsu, P. Y., Chang, T. Y., Ho, C-L., Tzai, T. S. & Chow, N-H., 2005 May 23, In : British Journal of Cancer. 92, 10, p. 1906-1914 9 p.

Research output: Contribution to journalArticle

Transitional Cell Carcinoma
Urinary Bladder
Urinary Bladder Neoplasms
Proto-Oncogene Proteins c-met
RON protein
28 Citations (Scopus)
Malignant Pleural Effusion
Lung Neoplasms
Drug Therapy
Lung
Radiation
5 Citations (Scopus)
Life Expectancy
Quality of Life
Incidence
Health
Neoplasms
6 Citations (Scopus)
Uterine Cervical Neoplasms
radiation therapy
Radiotherapy
cancer
activation
5 Citations (Scopus)

Cost effectiveness of cancer treatment in Taiwan

Hung, M. C., Lai, W-W., Chen, H. H. W., Lee, J-C., Lin, Y-J., Hsiao, J-R., Cheng, Y-M., Shan, Y-S., Su, W-C. & Wang, J-D., 2016 Aug 1, In : Journal of the Formosan Medical Association. 115, 8, p. 609-618 10 p.

Research output: Contribution to journalArticle

Taiwan
Cost-Benefit Analysis
Quality-Adjusted Life Years
Gross Domestic Product
Neoplasms
4 Citations (Scopus)
DNA-Binding Proteins
Platinum
Cisplatin
Copper
Homeostasis
52 Citations (Scopus)

Elevated glutathione levels confer cellular sensitization to cisplatin toxicity by up-regulation of copper transporter hCtr1

Chen, H. H. W., Song, I. S., Hossain, A., Choi, M. K., Yamane, Y., Liang, Z. D., Lu, J., Wu, L. Y. H., Siddik, Z. H., Klomp, L. W. J., Savaraj, N. & Kuo, M. T., 2008 Sep 1, In : Molecular Pharmacology. 74, 3, p. 697-704 8 p.

Research output: Contribution to journalArticle

Cisplatin
Glutathione
Copper
Up-Regulation
Glutamate-Cysteine Ligase
13 Citations (Scopus)

Estimating the lifelong health impact and financial burdens of different types of lung cancer

Yang, S-C., Lai, W-W., Su, W-C., Wu, S-Y., Chen, H. H. W., Wu, Y. L., Hung, M. C. & Wang, J-D., 2013 Dec 5, In : BMC cancer. 13, 579.

Research output: Contribution to journalArticle

Lung Neoplasms
Quality of Life
Life Expectancy
Health
Health Expenditures
9 Citations (Scopus)
Life Expectancy
Lung Neoplasms
Quality of Life
Non-Small Cell Lung Carcinoma
Quality-Adjusted Life Years
4 Citations (Scopus)

Ethmoid sinus cancer: Results of treatment with surgery and combined therapy

Lin, C-Y., Chen, H. H. W., Chen, H. H., Fang, S-Y. & Tsai, S-T., 2004 Dec 1, In : Acta Oto-Laryngologica. 124, 10, p. 1220-1225 6 p.

Research output: Contribution to journalArticle

Ethmoid Sinus
Neoplasms
Neoplasm Metastasis
Therapeutics
Neck
15 Citations (Scopus)
Genetic Promoter Regions
Single Nucleotide Polymorphism
Tumor Necrosis Factor-alpha
Genes
Alleles
25 Citations (Scopus)
acceleration (physics)
radiation therapy
Radiotherapy
cancer
Neck
32 Citations (Scopus)

Experience of radiotherapy in lethal midline granuloma with special emphasis on centrofacial T-cell lymphoma: A retrospective analysis covering a 34-year period

Chen, H. H. W., Fong, L., Su, I. J., Ting, L. L., Hong, R. L., Leung, H. W. C. & Lui, L. T., 1996 Jan 1, In : Radiotherapy and Oncology. 38, 1, p. 1-6 6 p.

Research output: Contribution to journalArticle

Lethal Midline Granuloma
T-Cell Lymphoma
Cell Lineage
Lymphoma
Radiotherapy
75 Citations (Scopus)

Expression of S100A4 and Met: Potential Predictors for Metastasis and Survival in Early-Stage Breast Cancer

Lee, W. Y., Su, W-C., Lin, P. W., Guo, H-R., Chang, T. W. & Chen, H. H. W., 2004 Oct 27, In : Oncology. 66, 6, p. 429-438 10 p.

Research output: Contribution to journalArticle

Disease-Free Survival
Breast Neoplasms
Neoplasm Metastasis
Survival
Neoplasms
1 Citation (Scopus)
Nasopharyngeal Neoplasms
Hematopoietic Stem Cell Transplantation
Feasibility Studies
Drug Therapy
Peripheral Blood Stem Cell Transplantation
31 Citations (Scopus)

Hypothyroidism After Radiotherapy for Nasopharyngeal Cancer Patients

Wu, Y-H., Wang, H. M., Chen, H. H. W., Lin, C. Y., Chen, E. Y. C., Fan, K. H., Huang, S. F., Chen, I. H., Liao, C. T., Cheng, A. J. & Chang, J. T. C., 2010 Mar 15, In : International Journal of Radiation Oncology Biology Physics. 76, 4, p. 1133-1139 7 p.

Research output: Contribution to journalArticle

Nasopharyngeal Neoplasms
Hypothyroidism
radiation therapy
Radiotherapy
cancer
49 Citations (Scopus)

Hypoxia-inducible factor-1α correlates with MET and metastasis in node-negative breast cancer

Chen, H. H. W., Su, W-C., Lin, P. W., Guo, H-R. & Lee, W. Y., 2007 Jun 1, In : Breast Cancer Research and Treatment. 103, 2, p. 167-175 9 p.

Research output: Contribution to journalArticle

Hypoxia-Inducible Factor 1
Breast Neoplasms
Neoplasm Metastasis
Disease-Free Survival
Survival Rate
31 Citations (Scopus)

IGF-1 upregulates electroneutral K-Cl cotransporter KCC3 and KCC4 which are differentially required for breast cancer cell proliferation and invasiveness

Hsu, Y. M., Chou, C-Y., Chen, H. H. W., Lee, W. Y., Chen, Y. F., Lin, P. W., Alper, S. L., Ellory, J. C. & Shen, M-R., 2007 Mar 1, In : Journal of Cellular Physiology. 210, 3, p. 626-636 11 p.

Research output: Contribution to journalArticle

Cell proliferation
Somatomedins
Up-Regulation
Cell Proliferation
Breast Neoplasms
34 Citations (Scopus)

Immunohistochemical analysis of epidermal growth factor receptor family members in stage I non-small cell lung cancer

Lai, W. W., Chen, F. F., Wu, M. H., Chow, N. H., Su, W. C., Ma, M. C., Su, P. F., Chen, H., Lin, M. Y. & Tseng, Y. L., 2001 Dec 1, In : Annals of Thoracic Surgery. 72, 6, p. 1868-1876 9 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Recurrence
Neoplasms
Tumor Biomarkers
169 Citations (Scopus)
Gold
Nanoparticles
Electrons
Neoplasms
Melanoma
47 Citations (Scopus)
Nitric Oxide Synthase Type II
Cyclooxygenase 2
nitric oxide
Nitric Oxide Synthase
Uterine Cervical Neoplasms
66 Citations (Scopus)
Hepatocellular Carcinoma
Tumor Necrosis Factor-alpha
Alleles
Genes
Hepatitis C
7 Citations (Scopus)

Inhibiting glucosylceramide synthase facilitates the radiosensitizing effects of vinorelbine in lung adenocarcinoma cells

Chiu, W-H., Chen, H. H. W., Chang, J-Y., Luo, S. J., Li, C. L., Chen, C. L., Su, W-C. & Lin, C. F., 2014 Jul 28, In : Cancer Letters. 349, 2, p. 144-151 8 p.

Research output: Contribution to journalArticle

ceramide glucosyltransferase
Radiation-Sensitizing Agents
Chemoradiotherapy
JNK Mitogen-Activated Protein Kinases
Apoptosis
13 Citations (Scopus)
Intensity-Modulated Radiotherapy
Mouth
Squamous Cell Carcinoma
Radiotherapy
Survival Rate
66 Citations (Scopus)

Interleukin-17-producing cell infiltration in the breast cancer tumour microenvironment is a poor prognostic factor

Chen, W. C., Lai, Y. H., Chen, H. Y., Guo, H. R., Su, I. J. & Chen, H. H. W., 2013 Aug 1, In : Histopathology. 63, 2, p. 225-233 9 p.

Research output: Contribution to journalArticle

Tumor Microenvironment
Interleukin-17
Breast Neoplasms
Disease-Free Survival
Th17 Cells
10 Citations (Scopus)

Isolated osteoradionecrosis of the dens mimicking metastasis of nasopharyngeal carcinoma after radiotherapy

Lee, J-S., Huang, C. M., Yeh, I. C., Chen, H. H. W., Lin, J. C. & Chen, H. H., 2010 Aug 1, In : Journal of Clinical Neuroscience. 17, 8, p. 1064-1066 3 p.

Research output: Contribution to journalArticle

Osteoradionecrosis
Radiotherapy
Neoplasm Metastasis
Spine
Nasopharynx
45 Citations (Scopus)

Mechanistic basis for overcoming platinum resistance using copper chelating agents

Liang, Z. D., Long, Y., Tsai, W. B., Fu, S., Kurzrock, R., Gagea-Iurascu, M., Zhang, F., Chen, H. H. W., Hennessy, B. T., Mills, G. B., Savaraj, N. & Kuo, M. T., 2012 Nov 1, In : Molecular Cancer Therapeutics. 11, 11, p. 2483-2494 12 p.

Research output: Contribution to journalArticle

Chelating Agents
Platinum
Copper
Drug Resistance
Ovarian Neoplasms
57 Citations (Scopus)
STAT3 Transcription Factor
AMP-Activated Protein Kinases
Metformin
Cytotoxicity
Liver
19 Citations (Scopus)
Paclitaxel
Lung Neoplasms
Survival
Reactive Oxygen Species
Drug Therapy
1 Citation (Scopus)

Modelling the wedge shape for the virtual wedge

Chang, L., Ho, S. Y. & Chen, H. H. W., 2003 Jun 21, In : Physics in Medicine and Biology. 48, 12, p. 1785-1794 10 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Molecular diagnosis of primary liver cancer by microsatellite DNA analysis in the serum

Chang, Y. C., Ho, C-L., Chen, H. H. W., Chang, T-T., Lai, W-W., Dai, Y. C., Lee, W. Y. & Chow, N-H., 2002 Dec 2, In : British Journal of Cancer. 87, 12, p. 1449-1453 5 p.

Research output: Contribution to journalArticle

Liver Neoplasms
Microsatellite Repeats
Hepatocellular Carcinoma
Loss of Heterozygosity
Cholangiocarcinoma
7 Citations (Scopus)

Neurophysiological and histopathological evaluation of low-dose radiation on the cauda equina and postlaminotomy fibrosis: An experimental study in the rat

Su, W-R., Lee, J-S., Chen, H. H. W., Wang, L-C., Huang, Y. H., Jung, Y. C. & Jou, I. M., 2009 Mar 1, In : Spine. 34, 5, p. 463-469 7 p.

Research output: Contribution to journalArticle

Cauda Equina
Fibrosis
Radiation
Somatosensory Evoked Potentials
Radiotherapy
23 Citations (Scopus)

Nutritional predictors of survival in terminally ill cancer patients

Ho, S. Y., Guo, H. R., Chen, H. H. W. & Peng, C. J., 2003 Aug 1, In : Journal of the Formosan Medical Association. 102, 8, p. 544-550 7 p.

Research output: Contribution to journalArticle

Terminally Ill
Confidence Intervals
Survival
Neoplasms
Nutrition Assessment
15 Citations (Scopus)

Overcoming platinum drug resistance with copper-lowering agents

Chen, H. H. W. & Kuo, M. T., 2013 Oct 1, In : Anticancer Research. 33, 10, p. 4157-4162 6 p.

Research output: Contribution to journalArticle

Platinum
Drug Resistance
Copper
Drug Therapy
Carboplatin
19 Citations (Scopus)
Adjuvant Radiotherapy
Mastectomy
Taiwan
Breast Neoplasms
Neoplasm Metastasis