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Research Output 1989 2019

2019

Curcumin functions as a MEK inhibitor to induce a synthetic lethal effect on KRAS mutant colorectal cancer cells receiving targeted drug regorafenib

Wu, C. S., Wu, S. Y., Chen, H. C., Chu, C. A., Tang, H. H., Liu, H. S., Hong, Y. R., Huang, C. Y. F., Huang, G. C. & Su, C. L., 2019 Dec, In : Journal of Nutritional Biochemistry. 74, 108227.

Research output: Contribution to journalArticle

Curcumin
HCT116 Cells
Mitogen-Activated Protein Kinase Kinases
Colorectal Neoplasms
Cells
3 Citations (Scopus)

Degradative autophagy selectively regulates CCND1 (cyclin D1) and MIR224, two oncogenic factors involved in hepatocellular carcinoma tumorigenesis

Wu, S. Y., Lan, S. H. & Liu, H-S., 2019 Apr 3, In : Autophagy. 15, 4, p. 729-730 2 p.

Research output: Contribution to journalComment/debate

Cyclin D1
Autophagy
Hepatocellular Carcinoma
Carcinogenesis
Cell Cycle
2 Citations (Scopus)

MiR-338-5p promotes metastasis of colorectal cancer by inhibition of phosphatidylinositol 3-kinase, catalytic subunit type 3-mediated autophagy pathway

Chu, C. A., Lee, C-T., Lee, J-C., Wang, Y. W., Huang, C. T., Lan, S. H., Lin, P-C., Lin, P-W., Tian, Y. F., Liu, H-S. & Chow, N-H., 2019 May 1, In : EBioMedicine. 43, p. 270-281 12 p.

Research output: Contribution to journalArticle

Open Access
Class III Phosphatidylinositol 3-Kinases
Autophagy
Tumors
Colorectal Neoplasms
Genes
2018
17 Citations (Scopus)

Dengue virus-induced ER stress is required for autophagy activation, viral replication, and pathogenesis both in vitro and in vivo

Lee, Y. R., Kuo, S. H., Lin, C. Y., Fu, P. J., Lin, Y-S., Yeh, T-M. & Liu, H-S., 2018 Dec 1, In : Scientific reports. 8, 1, 489.

Research output: Contribution to journalArticle

Virus Activation
Dengue Virus
Endoplasmic Reticulum Stress
Autophagy
Virus Diseases
15 Citations (Scopus)

Hepatocellular carcinoma–related cyclin D1 is selectively regulated by autophagy degradation system

Wu, S. Y., Lan, S. H., Wu, S-R., Chiu, Y. C., Lin, X-Z., Su, I. J., Tsai, T. F., Yen, C-J., Lu, T-H., Liang, F. W., Li, C-Y., Su, H-J., Su, C. L. & Liu, H-S., 2018 Jul 1, In : Hepatology. 68, 1, p. 141-154 14 p.

Research output: Contribution to journalArticle

Cyclin D1
Autophagy
Hepatocellular Carcinoma
Neoplasms
Carcinogenesis
1 Citation (Scopus)

VAMP8, a vesicle-SNARE required for RAB37-mediated exocytosis, possesses a tumor metastasis suppressor function

Wang, Y., Tzeng, H., Tsai, C., Cheng, H., Lai, W., Liu, H. & Wang, Y., 2018 Nov 1, In : Cancer Letters. 437, p. 79-88

Research output: Contribution to journalArticle

2017
1 Citation (Scopus)

Arsenic treatment increase Aurora-A overexpression through E2F1 activation in bladder cells

Kao, Y. T., Wu, C. H., Wu, S. Y., Lan, S. H., Liu, H-S. & Tseng, Y. S., 2017 Apr 18, In : BMC cancer. 17, 1, 277.

Research output: Contribution to journalArticle

Arsenic
Urinary Bladder
Cell Proliferation
Centrosome
Carcinogenesis
4 Citations (Scopus)

Honeysuckle aqueous extract and induced let-7a suppress dengue virus type 2 replication and pathogenesis

Lee, Y. R., Yeh, S. F., Ruan, X. M., Zhang, H., Hsu, S. D., Huang, H. D., Hsieh, C. C., Lin, Y-S., Yeh, T-M., Liu, H-S. & Gan, D. D., 2017 Feb 23, In : Journal of Ethnopharmacology. 198, p. 109-121 13 p.

Research output: Contribution to journalArticle

Lonicera
Dengue Virus
Virus Replication
MicroRNAs
High-Throughput Nucleotide Sequencing
5 Citations (Scopus)

MED28 Regulates Epithelial–Mesenchymal Transition Through NFκB in Human Breast Cancer Cells

Huang, C. Y., Hsieh, N. T., Li, C. I., Weng, Y. T., Liu, H-S. & Lee, M. F., 2017 Jun 1, In : Journal of Cellular Physiology. 232, 6, p. 1337-1345 9 p.

Research output: Contribution to journalArticle

Cells
Cell growth
Cadherins
Breast Neoplasms
MCF-7 Cells
15 Citations (Scopus)

Metformin promotes apoptosis in hepatocellular carcinoma through the CEBPD-induced autophagy pathway

Tsai, H. H., Lai, H. Y., Chen, Y. C., Li, C. F., Huang, H-S., Liu, H-S., Tsai, Y-S. & Wang, J-M., 2017 Jan 1, In : Oncotarget. 8, 8, p. 13832-13845 14 p.

Research output: Contribution to journalArticle

CCAAT-Enhancer-Binding Protein-delta
Metformin
Autophagy
Hepatocellular Carcinoma
Apoptosis
3 Citations (Scopus)

The role of Lutheran/basal cell adhesion molecule in human bladder carcinogenesis

Chang, H. Y., Chang, H. M., Wu, T. J., Chaing, C. Y., Tzai, T. S., Cheng, H-L., Raghavaraju, G., Chow, N-H. & Liu, H-S., 2017 Aug 26, In : Journal of biomedical science. 24, 1, 61.

Research output: Contribution to journalArticle

Cell Adhesion Molecules
Carcinogenesis
Urinary Bladder
Cell adhesion
Cell Adhesion
9 Citations (Scopus)

Using gene expression database to uncover biology functions of 1,4-disubstituted 1,2,3-triazole analogues synthesized via a copper (I)-catalyzed reaction

Su, C. L., Tseng, C. L., Ramesh, C., Liu, H-S., Huang, C. Y. F. & Yao, C. F., 2017 Jan 1, In : European Journal of Medicinal Chemistry. 132, p. 90-107 18 p.

Research output: Contribution to journalArticle

Triazoles
Cytotoxicity
Gene expression
Copper
Hepatocellular Carcinoma
2016
5 Citations (Scopus)

A novel natural tautomeric pair of garcinielliptone FC suppressed nuclear factor κB and induced apoptosis in human colorectal cancer cells

Won, S. J., Lin, T. Y., Yen, C. H., Tzeng, Y. H., Liu, H-S., Lin, C. N., Yu, C. H., Wu, C. S., Chen, J. T., Chen, Y. T., Huang, C. Y. F. & Su, C. L., 2016 Jun 1, In : Journal of Functional Foods. 24, p. 568-578 11 p.

Research output: Contribution to journalArticle

caspases
colorectal neoplasms
Garcinia subelliptica
Colorectal Neoplasms
Western blotting
11 Citations (Scopus)

Autophagy and microRNA in hepatitis B virus-related hepatocellular carcinoma

Wu, S. Y., Lan, S. H. & Liu, H-S., 2016 Jan 7, In : World journal of gastroenterology. 22, 1, p. 176-187 12 p.

Research output: Contribution to journalReview article

Autophagy
MicroRNAs
Hepatitis B virus
Hepatocellular Carcinoma
Virus Diseases
30 Citations (Scopus)
Macrophage Migration-Inhibitory Factors
Dengue Virus
Severe Dengue
Autophagy
Blood Vessels

Evaluation of cellular retinoic acid binding protein 2 gene expression through the retinoic acid pathway by co-incubation of Blastocystis ST-1 with HT29 cells in vitro

Liao, C. C., Song, E. J., Chang, T. Y., Lin, W-C., Liu, H-S., Chen, L. R., Huang, L. L-H. & Shin, J-W., 2016 May 1, In : Parasitology Research. 115, 5, p. 1965-1975 11 p.

Research output: Contribution to journalArticle

Blastocystis
HT29 Cells
Retinoic Acid Receptors
retinoic acid
Tretinoin
2015
4 Citations (Scopus)

Antiangiogenesis as the novel mechanism for justicidin A in the anticancer effect on human bladder cancer

Wang, Y. W., Chuang, J. J., Chang, T. Y., Won, S. J., Tsai, H-W., Lee, C-T., Cheng, H-L., Tzai, T. S., Liu, H-S. & Chow, N-H., 2015 Jan 1, In : Anti-Cancer Drugs. 26, 4, p. 428-436 9 p.

Research output: Contribution to journalArticle

Urinary Bladder Neoplasms
SCID Mice
Justicia
Neoplasms
Cell Proliferation
6 Citations (Scopus)

Correlation between serum levels of anti-endothelial cell autoantigen and anti-dengue virus nonstructural protein 1 antibodies in dengue patients

Cheng, H. J., Luo, Y. H., Wan, S. W., Lin, C. F., Wang, S-T., Hung, N. T., Liu, C-C., Ho, T-S., Liu, H-S., Yeh, T-M. & Lin, Y-S., 2015 May 1, In : American Journal of Tropical Medicine and Hygiene. 92, 5, p. 989-995 7 p.

Research output: Contribution to journalArticle

Dengue Virus
Dengue
Autoantigens
Protein Disulfide-Isomerases
Immunoglobulin M
5 Citations (Scopus)

Discovery of molecular mechanisms of lignan justicidin A using L1000 gene expression profiles and the Library of Integrated Network-based Cellular Signatures database

Won, S. J., Wu, H. C., Lin, K. T., Yu, C. H., Chen, Y. T., Wu, C. S., Huang, C. Y. F., Liu, H-S., Lin, C. N. & Su, C. L., 2015 Jun 1, In : Journal of Functional Foods. 16, p. 81-93 13 p.

Research output: Contribution to journalArticle

Lignans
lignans
Transcriptome
Libraries
autophagy
21 Citations (Scopus)

Justicidin A-Induced autophagy flux enhances apoptosis of human colorectal cancer cells via class III PI3K and Atg5 pathway

Won, S. J., Yen, C. H., Liu, H-S., Wu, S. Y., Lan, S. H., Jiang-Shieh, Y. F., Lin, C. N. & Su, C. L., 2015 Apr 1, In : Journal of Cellular Physiology. 230, 4, p. 930-946 17 p.

Research output: Contribution to journalArticle

Autophagy
Phosphatidylinositol 3-Kinases
Colorectal Neoplasms
Cells
Apoptosis
10 Citations (Scopus)

Ras induces experimental lung metastasis through up-regulation of RbAp46 to suppress RECK promoter activity

Yeh, H. H., Tseng, Y. F., Hsu, Y. C., Lan, S. H., Wu, S. Y., Raghavaraju, G., Cheng, D. E., Lee, Y. R., Chang, T. Y., Chow, N-H., Hung, W. C. & Liu, H-S., 2015 Mar 25, In : BMC Cancer. 15, 1, 172.

Research output: Contribution to journalArticle

Up-Regulation
Urinary Bladder Neoplasms
Neoplasm Metastasis
Lung
Genes
9 Citations (Scopus)

SH3BGRL3 Protein as a Potential Prognostic Biomarker for Urothelial Carcinoma: A Novel Binding Partner of Epidermal Growth Factor Receptor

Chiang, C. Y., Pan, C. C., Chang, H. Y., Lai, M-D., Tzai, T. S., Tsai, Y-S., Ling, P., Liu, H-S., Lee, B-F., Cheng, H-L., Ho, C-L., Chen, S-H. & Chow, N-H., 2015 Dec 15, In : Clinical Cancer Research. 21, 24, p. 5601-5611 11 p.

Research output: Contribution to journalArticle

src Homology Domains
Epidermal Growth Factor Receptor
Glutamic Acid
Biomarkers
Carcinoma
2014
7 Citations (Scopus)

An increase in integrin-linked kinase noncanonically confers NF-κB-mediated growth advantages to gastric cancer cells by activating ERK1/2

Tseng, P. C., Chen, C. L., Shan, Y-S., Chang, W. T., Liu, H-S., Hong, T-M., Hsieh, C. Y., Lin, S-H. & Lin, C. F., 2014 Jan 1, In : Cell Communication and Signaling. 12, 1, 69.

Research output: Contribution to journalArticle

Stomach Neoplasms
Cells
Growth
Cell growth
Chemical activation
26 Citations (Scopus)

Autophagy-preferential degradation of MIR224 participates in hepatocellular carcinoma tumorigenesis

Lan, S. H., Wu, S. Y., Zuchini, R., Lin, X-Z., Su, I. J., Tsai, T. F., Lin, Y. J., Wu, C. T. & Liu, H-S., 2014 Sep 1, In : Autophagy. 10, 9, p. 1687-1689 3 p.

Research output: Contribution to journalArticle

Autophagy
MicroRNAs
Hepatocellular Carcinoma
Carcinogenesis
Amiodarone
103 Citations (Scopus)

Autophagy suppresses tumorigenesis of hepatitis B virus-associated hepatocellular carcinoma through degradation of microRNA-224

Lan, S. H., Wu, S. Y., Zuchini, R., Lin, X-Z., Su, I. J., Tsai, T. F., Lin, Y. J., Wu, C. T. & Liu, H-S., 2014 Feb 1, In : Hepatology. 59, 2, p. 505-517 13 p.

Research output: Contribution to journalArticle

Autophagy
MicroRNAs
Hepatitis B virus
Hepatocellular Carcinoma
Carcinogenesis
17 Citations (Scopus)
platinum
Curcumin
curcumin
antineoplastic agents
Platinum
14 Citations (Scopus)

Curcumin-induced aurora-a suppression not only causes mitotic defect and cell cycle arrest but also alters chemosensitivity to anticancer drugs

Ke, C. S., Liu, H-S., Yen, C. H., Huang, G. C., Cheng, H-C., Huang, C. Y. F. & Su, C. L., 2014 Jan 1, In : Journal of Nutritional Biochemistry. 25, 5, p. 526-539 14 p.

Research output: Contribution to journalArticle

Curcumin
Cell Cycle Checkpoints
Cells
Defects
Pharmaceutical Preparations
28 Citations (Scopus)

Enterovirus 71-induced autophagy increases viral replication and pathogenesis in a suckling mouse model

Lee, Y. R., Wang, P. S., Wang, J-R. & Liu, H-S., 2014 Aug 20, In : Journal of biomedical science. 21, 1, 80.

Research output: Contribution to journalArticle

Enterovirus
Autophagy
Enterovirus Infections
Proteins
Fluxes
17 Citations (Scopus)

Hypoxia promotes nuclear translocation and transcriptional function in the oncogenic tyrosine kinase RON

Chang, H. Y., Liu, H-S., Lai, M-D., Tsai, Y-S., Tzai, T. S., Cheng, H-L. & Chow, N-H., 2014 Aug 15, In : Cancer Research. 74, 16, p. 4549-4562 14 p.

Research output: Contribution to journalArticle

Protein-Tyrosine Kinases
Neoplasms
Cell Survival
Hypoxia-Inducible Factor 1
Receptor Protein-Tyrosine Kinases
14 Citations (Scopus)
molecular mimicry
Molecular Mimicry
fibrinolysis
Dengue virus
Dengue Virus
13 Citations (Scopus)

Potential significance of EMP3 in patients with upper urinary tract urothelial carcinoma: Crosstalk with ErbB2-PI3K-Akt pathway

Wang, Y. W., Li, W. M., Wu, W. J., Chai, C. Y., Liu, H-S., Lai, M-D. & Chow, N-H., 2014 Jan 1, In : Journal of Urology. 192, 1, p. 242-251 10 p.

Research output: Contribution to journalArticle

Urinary Tract
Phosphatidylinositol 3-Kinases
Carcinoma
Cell Adhesion
Cell Movement
23 Citations (Scopus)

Protection against dengue virus infection in mice by administration of antibodies against modified nonstructural protein 1

Wan, S. W., Lu, Y. T., Huang, C. H., Lin, C. F., Anderson, R., Liu, H-S., Yeh, T-M., Yen, Y. T., Wu-Hsieh, B. A. & Lin, Y-S., 2014 Mar 21, In : PloS one. 9, 3, e92495.

Research output: Contribution to journalArticle

Dengue virus
Dengue Virus
Virus Diseases
Viruses
antibodies
Integrins
Disclosure
Pharmaceutical Preparations
6 Citations (Scopus)

SPAK mediates KCC3-enhanced cervical cancer tumorigenesis

Chiu, M. H., Liu, H-S., Wu, Y. H., Shen, M-R. & Chou, C-Y., 2014 Jan 1, In : FEBS Journal. 281, 10, p. 2353-2365 13 p.

Research output: Contribution to journalArticle

Symporters
Uterine Cervical Neoplasms
Carcinogenesis
Matrix Metalloproteinase 2
p38 Mitogen-Activated Protein Kinases
2013
12 Citations (Scopus)

Antibodies against thrombin in dengue patients contain both anti-thrombotic and pro-fibrinolytic activities

Chuang, Y. C., Lin, Y. S., Liu, H. S., Wang, J. R. & Yeh, T. M., 2013 Aug 2, In : Thrombosis and Haemostasis. 110, 2, p. 358-365 8 p.

Research output: Contribution to journalArticle

Dengue
Thrombin
Antibodies
Severe Dengue
Dengue Virus
21 Citations (Scopus)

Anti-dengue virus nonstructural protein 1 antibodies cause NO-mediated endothelial cell apoptosis via ceramide-regulated glycogen synthase kinase-3β and NF-κB activation

Chen, C. L., Lin, C. F., Wan, S. W., Wei, L. S., Chen, M. C., Yeh, T-M., Liu, H-S., Anderson, R. & Lin, Y-S., 2013 Aug 15, In : Journal of Immunology. 191, 4, p. 1744-1752 9 p.

Research output: Contribution to journalArticle

Glycogen Synthase Kinase 3
Dengue Virus
Ceramides
Endothelial Cells
Apoptosis

Arsenic-induced Aurora-A activation contributes to chromosome instability and tumorigenesis

Wu, C. H., Tseng, Y. S., Yang, C-C., Kao, Y. T., Sheu, H. M. & Liu, H-S., 2013 Nov 5, In : Journal of Asian Earth Sciences. 77, p. 338-341 4 p.

Research output: Contribution to journalArticle

aurora
chromosome
arsenic
cancer
skin
41 Citations (Scopus)

Autoimmunity in dengue pathogenesis

Wan, S. W., Lin, C. F., Yeh, T-M., Liu, C-C., Liu, H-S., Wang, S-Y., Ling, P., Anderson, R., Lei, H. Y. & Lin, Y-S., 2013 Jan 1, In : Journal of the Formosan Medical Association. 112, 1, p. 3-11 9 p.

Research output: Contribution to journalReview article

Dengue Virus
Dengue
Severe Dengue
Autoimmunity
Virus Diseases
9 Citations (Scopus)

Characterization of a colorectal cancer migration and autophagy-related microRNA miR-338-5p and its target gene PIK3C3

Ju, J. A., Huang, C. T., Lan, S. H., Wang, T. H., Lin, P-C., Lee, J. C., Tian, Y. F. & Liu, H-S., 2013 Sep 1, In : Biomarkers and Genomic Medicine. 5, 3, p. 74-78 5 p.

Research output: Contribution to journalArticle

Autophagy
MicroRNAs
Tumors
Colorectal Neoplasms
Genes
48 Citations (Scopus)

Current progress in dengue vaccines

Wan, S. W., Lin, C. F., Wang, S-Y., Chen, Y-H., Yeh, T-M., Liu, H-S., Anderson, R. & Lin, Y-S., 2013 Jun 17, In : Journal of biomedical science. 20, 1, 37.

Research output: Contribution to journalReview article

Dengue Vaccines
Viruses
Severe Dengue
Attenuated Vaccines
Dengue
13 Citations (Scopus)
Cyclooxygenase 2
Colorectal Neoplasms
Neoplasms
Carcinogenesis
Mucous Membrane
47 Citations (Scopus)

Dengue virus infection induces autophagy: An in vivo study

Lee, Y. R., Hu, H. Y., Kuo, S. H., Lei, H. Y., Lin, Y-S., Yeh, T-M., Liu, C-C. & Liu, H-S., 2013 Sep 11, In : Journal of biomedical science. 20, 1, 65.

Research output: Contribution to journalArticle

Dengue Virus
Autophagy
Virus Diseases
Viruses
Virus Replication
10 Citations (Scopus)

Depth-resolved abundance and diversity of arsenite-oxidizing bacteria in the groundwater of Beimen, a blackfoot disease endemic area of southwestern Taiwan

Das, S., Kar, S., Jean, J. S., Rathod, J., Chakraborty, S., Liu, H. S. & Bundschuh, J., 2013 Dec 1, In : Water Research. 47, 19, p. 6983-6991 9 p.

Research output: Contribution to journalArticle

arsenite
Arsenic
Groundwater
arsenic
Bacteria
7 Citations (Scopus)

Epithelial membrane protein 2 is a prognostic indictor for patients with urothelial carcinoma of the upper urinary tract

Wang, Y. W., Li, W. M., Wu, W. J., Chai, C. Y., Chang, T. Y., Sun, Y., Cheng, C. J., Shiue, Y. L., Su, S. J., Cheng, H-L., Liu, H-S. & Chow, N-H., 2013 Sep 1, In : American Journal of Pathology. 183, 3, p. 709-719 11 p.

Research output: Contribution to journalArticle

Urinary Tract
Membrane Proteins
Carcinoma
Integrins
Severe Combined Immunodeficiency
17 Citations (Scopus)

Factors contributing to the disturbance of coagulation and fibrinolysis in dengue virus infection

Chuang, Y. C., Lin, Y-S., Liu, C-C., Liu, H-S., Liao, S. H., Shi, M. D., Lei, H. Y. & Yeh, T-M., 2013 Jan 1, In : Journal of the Formosan Medical Association. 112, 1, p. 12-17 6 p.

Research output: Contribution to journalReview article

Dengue Virus
Fibrinolysis
Virus Diseases
Hemorrhage
Severe Dengue
16 Citations (Scopus)

Glycosylation regulates the function and membrane localization of KCC4

Weng, T. Y., Chiu, W-T., Liu, H-S., Cheng, H-C., Shen, M-R., Mount, D. B. & Chou, C-Y., 2013 May 1, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1833, 5, p. 1133-1146 14 p.

Research output: Contribution to journalArticle

Glycosylation
Membranes
Polysaccharides
Mutation
Protein Folding
11 Citations (Scopus)

Low concentration of arsenic-induced aberrant mitosis in keratinocytes through E2F1 transcriptionally regulated aurora-A

Wu, C. H., Tseng, Y. S., Kao, Y. T., Sheu, H. M. & Liu, H-S., 2013 Mar 1, In : Toxicological Sciences. 132, 1, p. 43-52 10 p.

Research output: Contribution to journalArticle

Arsenic
Keratinocytes
Mitosis
Centrosome
Chromosomes
10 Citations (Scopus)
Malignant Pleural Effusion
Capillary Permeability
Thromboplastin
adenocarcinoma
blood vessels
2012
oxaliplatin
Marginal Zone B-Cell Lymphoma
Gene expression
Adenocarcinoma
Cells
45 Citations (Scopus)

Dengue virus nonstructural protein NS1 binds to prothrombin/thrombin and inhibits prothrombin activation

Lin, S. W., Chuang, Y. C., Lin, Y-S., Lei, H. Y., Liu, H-S. & Yeh, T-M., 2012 Mar 1, In : Journal of Infection. 64, 3, p. 325-334 10 p.

Research output: Contribution to journalArticle

Dengue Virus
Prothrombin
Thrombin
Dengue
Hemorrhage