• 522 Citations
  • 12 h-Index
20102019
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Research Output 2010 2019

  • 522 Citations
  • 12 h-Index
  • 42 Article
  • 2 Review article
  • 1 Comment/debate
  • 1 Letter
2019

Chemical constituents from Phalaenopsis hybrids and their bioactivities

Lam, S-H., Hung, H-Y., Yang, M. L., Chen, H-H., Kuo, P-C. & Wu, T-S., 2019 May 1, In : Natural Product Communications. 14, 5

Research output: Contribution to journalArticle

Open Access
Orchidaceae
Phalaenopsis
flavone
extracts
flavones

Chemical constituents from the stems of Machilus philippinensis Merr. and the neuroprotective activity of cinnamophilin

Tai, S. H., Kuo, P-C., Lam, S. H., Huang, S. C., Kuo, Y. Z., Hung, H-Y., Liou, M. J., Shieh, P. C., Lee, E-J. & Wu, T. S., 2019 Jan 1, In : RSC Advances. 9, 38, p. 21616-21625 10 p.

Research output: Contribution to journalArticle

Open Access
Acids
Bioactivity
Neurons
Medicine
Methanol
2018
3 Citations (Scopus)

A feasible and practical 1H NMR analytical method for the quality control and quantification of bioactive principles in Lycii Fructus

Hsieh, L. Y., Chan, H. H., Kuo, P-C., Hung, H-Y., Li, Y. C., Kuo, C. L., Peng, Y., Zhao, Z. Z., Kuo, D. H., Sun, I-W. & Wu, T-S., 2018 Jul 1, In : Journal of Food and Drug Analysis. 26, 3, p. 1105-1112 8 p.

Research output: Contribution to journalArticle

Quality Control
quality control
analytical methods
Betaine
betaine

Chemical constituents from the stems of tinospora sinensis and their bioactivity

Lam, S-H., Chen, P. H., Hung, H-Y., Hwang, T. L., Chiang, C. C., Thang, T. D., Kuo, P-C. & Wu, T-S., 2018 Oct 5, In : Molecules. 23, 10, 2541.

Research output: Contribution to journalArticle

Tinospora
N-Formylmethionine Leucyl-Phenylalanine
Lignans
Cytochalasin B
Pyrroles
1 Citation (Scopus)

Hepatoprotective Principles and Other Chemical Constituents from the Mycelium of Phellinus linteus

Huang, S. C., Wang, P. W., Kuo, P-C., Hung, H-Y. & Pan, T. L., 2018 Jul 12, In : Molecules (Basel, Switzerland). 23, 7

Research output: Contribution to journalArticle

fibrosis
Mycelium
rats
Rats
Norisoprenoids
8 Citations (Scopus)

Melatonin protects brain against ischemia/reperfusion injury by attenuating endoplasmic reticulum stress

Lin, Y. W., Chen, T. Y., Hung, C. Y., Tai, S-H., Huang, S. Y., Chang, C-C., Hung, H-Y. & Lee, E-J., 2018 Jul 1, In : International journal of molecular medicine. 42, 1, p. 182-192 11 p.

Research output: Contribution to journalArticle

Endoplasmic Reticulum Stress
Melatonin
Reperfusion Injury
Brain Ischemia
Eukaryotic Initiation Factor-2
1 Citation (Scopus)
Dendritic Spines
Transient Ischemic Attack
Brain Ischemia
Neuronal Plasticity
Stroke
1 Citation (Scopus)

The constituents of the stems of cissus assamica and their bioactivities

Chan, Y. Y., Wang, C. Y., Hwang, T. L., Juang, S. H., Hung, H-Y., Kuo, P-C., Chen, P. J. & Wu, T-S., 2018 Oct 28, In : Molecules. 23, 11, 23112799.

Research output: Contribution to journalArticle

Cissus
Bioactivity
stems
Inhibitory Concentration 50
acids
1 Citation (Scopus)

Therapeutic window for YC-1 following glutamate-induced neuronal damage and transient focal cerebral ischemia

Tai, S-H., Lee, W. T., Lee, A. C., Lin, Y. W., Hung, H-Y., Huang, S. Y., Wu, T-S. & Lee, E-J., 2018 May 1, In : Molecular Medicine Reports. 17, 5, p. 6490-6496 7 p.

Research output: Contribution to journalArticle

Transient Ischemic Attack
Glutamic Acid
Neurons
Therapeutics
Stroke
2017
9 Citations (Scopus)

Anti-inflammatory and neuroprotective constituents from the peels of citrus grandis

Kuo, P-C., Liao, Y. R., Hung, H-Y., Chuang, C. W., Hwang, T. L., Huang, S. C., Shiao, Y. J., Kuo, D. H. & Wu, T-S., 2017 Jun 1, In : Molecules. 22, 6, 967.

Research output: Contribution to journalArticle

Citrus
inorganic peroxides
Pancreatic Elastase
Superoxides
Anti-Inflammatory Agents
3 Citations (Scopus)

Anti-inflammatory Flavan-3-ol-dihydroretrochalcones from Daemonorops draco

Kuo, P-C., Hung, H-Y., Hwang, T. L., Du, W. K., Ku, H. C., Lee, E-J., Tai, S-H., Chen, F. A. & Wu, T-S., 2017 Apr 28, In : Journal of Natural Products. 80, 4, p. 783-789 7 p.

Research output: Contribution to journalArticle

Anti-Inflammatory Agents
Pancreatic Elastase
Chinese Traditional Medicine
Superoxides
Dimers

Characterization of cyclodepsipeptides from the mycelium of Isaria Japonica from Vietnam

Tuan, N. N., Ngan, N. T., Kuo, P-C., Hung, H-Y., Lan, T. N., Thanh, N. T., Xuan, D. T. T., Thang, T. D. & Wu, T-S., 2017 Jan 1, In : Natural Product Communications. 12, 3, p. 377-378 2 p.

Research output: Contribution to journalArticle

Depsipeptides
Vietnam
Mycelium
mycelium
Insects
11 Citations (Scopus)

Chemical Constituents and Anti-inflammatory Principles from the Fruits of Forsythia suspensa

Kuo, P-C., Hung, H-Y., Nian, C. W., Hwang, T. L., Cheng, J. C., Kuo, D. H., Lee, E-J., Tai, S-H. & Wu, T-S., 2017 Apr 28, In : Journal of Natural Products. 80, 4, p. 1055-1064 10 p.

Research output: Contribution to journalArticle

Forsythia
Lignans
Diterpenes
Pancreatic Elastase
Fruits
1 Citation (Scopus)

Constituents of the fruits of Citrus medica L. var. sarcodactylis and the effect of 6,7-dimethoxy-coumarin on superoxide anion formation and elastase release

Chan, Y. Y., Hwang, T. L., Kuo, P-C., Hung, H-Y. & Wu, T-S., 2017 Sep 1, In : Molecules. 22, 9, 1454.

Research output: Contribution to journalArticle

scoparone
fruits
Citrus
inorganic peroxides
Pancreatic Elastase
5 Citations (Scopus)

New bis(hydroxymethyl) alkanoate curcuminoid derivatives exhibit activity against triple-negative breast cancer in vitro and in vivo

Hsieh, M. T., Chang, L. C., Hung, H-Y., Lin, H. Y., Shih, M. H., Tsai, C. H., Kuo, S. C. & Lee, K. H., 2017 Jan 1, In : European Journal of Medicinal Chemistry. 131, p. 141-151 11 p.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Curcumin
Derivatives
Breast Neoplasms
Heterografts
15 Citations (Scopus)

Synthesis and biological evaluation of chalcone, dihydrochalcone, and 1,3-diarylpropane analogs as anti-inflammatory agents

Vijaya Bhaskar Reddy, M., Hung, H-Y., Kuo, P-C., Huang, G. J., Chan, Y. Y., Huang, S. C., Wu, S. J., Morris-Natschke, S. L., Lee, K. H. & Wu, T-S., 2017 Jan 1, In : Bioorganic and Medicinal Chemistry Letters. 27, 7, p. 1547-1550 4 p.

Research output: Contribution to journalArticle

Chalcones
Lead compounds
Chalcone
Macrophages
Peritoneal Macrophages
2016
6 Citations (Scopus)

A novel microtubule inhibitor, MT3-037, causes cancer cell apoptosis by inducing mitotic arrest and interfering with microtubule dynamics

Chang, L. C., Yu, Y. L., Hsieh, M. T., Wang, S. H., Chou, R. H., Huang, W. C., Lin, H. Y., Hung, H-Y., Huang, L. J. & Kuo, S. C., 2016 Jan 1, In : American Journal of Cancer Research. 6, 4, p. 747-763 17 p.

Research output: Contribution to journalArticle

Tubulin
Microtubules
CDC2 Protein Kinase
Apoptosis
Neoplasms
10 Citations (Scopus)

Anti-inflammatory neolignans from the roots of Magnolia officinalis

Shih, H. C., Kuo, P-C., Wu, S. J., Hwang, T. L., Hung, H-Y., Shen, D. Y., Shieh, P. C., Liao, Y. R., Lee, E-J., Gu, Q., Lee, K. H. & Wu, T-S., 2016 Apr 1, In : Bioorganic and Medicinal Chemistry. 24, 7, p. 1439-1445 7 p.

Research output: Contribution to journalArticle

Magnolia
Lignans
Anti-Inflammatory Agents
Derivatives
Pancreatic Elastase

Application of flow cytometry for evaluating clinical prognosis and histopathological grade of human glioma

Lin, Y. W., Tai, S-H., Chang, C-C., Chao, L-C., Wen, M-J., Huang, Y. H., Hung, H-Y. & Lee, E-J., 2016 Apr 21, In : Neurological Research. 38, 7, p. 625-633 9 p.

Research output: Contribution to journalArticle

G2 Phase
Glioma
Cell Division
Flow Cytometry
Cyclin B
3 Citations (Scopus)

A rapid quantitative 1H NMR analysis of kinsenoside and other bioactive principles from: Anoectochilus formosanus

Hsieh, L. Y., Chan, H. H., Hung, H-Y., Kuo, C. L., Wu, J. B., Sun, I-W., Kuo, P-C. & Wu, T-S., 2016 Jul 28, In : Analytical Methods. 8, 28, p. 5645-5650 6 p.

Research output: Contribution to journalArticle

Nuclear magnetic resonance
Benzyl Alcohol
Column chromatography
Benzoic Acid
Benzoic acid
11 Citations (Scopus)

Chemical Constituents of the Rhizomes of Bletilla formosana and Their Potential Anti-inflammatory Activity

Lin, C. W., Hwang, T. L., Chen, F. A., Huang, C. H., Hung, H-Y. & Wu, T-S., 2016 Aug 26, In : Journal of Natural Products. 79, 8, p. 1911-1921 11 p.

Research output: Contribution to journalArticle

Phenanthrenes
Rhizome
Bibenzyls
Anti-Inflammatory Agents
Pancreatic Elastase
5 Citations (Scopus)

Erratum: Dragonbloodin A1 and A2: Flavan Trimers and Anti-inflammatory Principles from Sanguis Draconis (Organic Letters)

Du, W. K., Hung, H-Y., Kuo, P-C., Hwang, T. L., Shiu, L. C., Shiu, K. B., Lee, E-J., Tai, S-H. & Wu, T-S., 2016 Jun 17, In : Organic Letters. 18, 12, 1 p.

Research output: Contribution to journalComment/debate

2 Citations (Scopus)

Four new compounds from edible algae Cladosiphon okamuranus and Chlorella sorokiniana and their bioactivities

Cheng, K. C., Kuo, P-C., Hung, H-Y., Yu, K. H., Hwang, T. L., Shieh, P. C., Chang, J-S. & Wu, T-S., 2016 Dec 1, In : Phytochemistry Letters. 18, p. 113-116 4 p.

Research output: Contribution to journalArticle

algae
Chlorella sorokiniana
Chlorella
Eicosapentaenoic Acid
Algae
2 Citations (Scopus)

Ionone derivatives from the mycelium of Phellinus linteus and the inhibitory effect on activated rat hepatic stellate cells

Huang, S. C., Kuo, P-C., Hung, H-Y., Pan, T. L., Chen, F. A. & Wu, T-S., 2016 May 6, In : International journal of molecular sciences. 17, 5, 681.

Research output: Contribution to journalLetter

Norisoprenoids
Hepatic Stellate Cells
fibrosis
Spectroscopic analysis
Mycelium
13 Citations (Scopus)

Recent progress on the traditional Chinese medicines that regulate the blood

Hung, H-Y. & Wu, T-S., 2016 Apr 1, In : Journal of Food and Drug Analysis. 24, 2, p. 221-238 18 p.

Research output: Contribution to journalReview article

Leonurus
Typhaceae
Corydalis
Rhizome
Chinese Traditional Medicine

Synthesis and characterization of 3-arylidenechroman-4-ones and their inhibitory effects on platelet aggregation activity

Reddy, M. V. B., Kuo, P-C., Hung, H-Y., Tsai, W. J. & Wu, T-S., 2016 Jan 1, In : Der Pharmacia Lettre. 8, 20, p. 14-20 7 p.

Research output: Contribution to journalArticle

Platelet Aggregation
Adenosine Diphosphate
Chromans
Thiophenes
Aldehydes
2015
3 Citations (Scopus)
reactivity
selectivity
Nucleophiles
Electrons
rings
1 Citation (Scopus)

New benzenoids from the roots of lindera aggregata

Ma, G. H., Lin, C. W., Hung, H-Y., Wang, S. Y., Shieh, P. C. & Wu, T-S., 2015 Jan 1, In : Natural Product Communications. 10, 12, p. 2131-2133 3 p.

Research output: Contribution to journalArticle

Lindera
linderagatin A
Carbon-13 Magnetic Resonance Spectroscopy
linderagatin B
15 Citations (Scopus)

Novel curcumin analogs to overcome EGFR-TKI lung adenocarcinoma drug resistance and reduce EGFR-TKI-induced GI adverse effects

Wada, K., Lee, J. Y., Hung, H-Y., Shi, Q., Lin, L., Zhao, Y., Goto, M., Yang, P. C., Kuo, S. C., Chen, H. W. & Lee, K. H., 2015 Apr 1, In : Bioorganic and Medicinal Chemistry. 23, 7, p. 1507-1514 8 p.

Research output: Contribution to journalArticle

Curcumin
Epidermal Growth Factor Receptor
Drug Resistance
Phosphorylation
Pharmaceutical Preparations
8 Citations (Scopus)

Novel Pyrazole Derivatives Effectively Inhibit Osteoclastogenesis, a Potential Target for Treating Osteoporosis

Kuo, T. H., Lin, T. H., Yang, R. S., Kuo, S. C., Fu, W. M. & Hung, H-Y., 2015 Jun 25, In : Journal of Medicinal Chemistry. 58, 12, p. 4954-4963 10 p.

Research output: Contribution to journalArticle

Osteogenesis
Osteoporosis
Osteoclasts
Bone Resorption
Therapeutics
7 Citations (Scopus)

The newly synthesized 2-arylnaphthyridin-4-one, CSC-3436, induces apoptosis of non-small cell lung cancer cells by inhibiting tubulin dynamics and activating CDK1

Chang, L. C., Yu, Y. L., Liu, C. Y., Cheng, Y. Y., Chou, R. H., Hsieh, M. T., Lin, H. Y., Hung, H-Y., Huang, L. J., Wu, Y. C. & Kuo, S. C., 2015 Jun 26, In : Cancer Chemotherapy and Pharmacology. 75, 6, p. 1303-1315 13 p.

Research output: Contribution to journalArticle

CDC2 Protein Kinase
Tubulin
Non-Small Cell Lung Carcinoma
Cells
Apoptosis
2 Citations (Scopus)

Total synthesis of cordatanine, structural reassignment of drymaritin, and anti-inflammatory activity of synthetic precursor

Fang, H. W., Liao, Y. R., Hwang, T. L., Shieh, P. C., Lee, K. H., Hung, H-Y. & Wu, T-S., 2015 Aug 17, In : Bioorganic and Medicinal Chemistry Letters. 25, 18, p. 3822-3824 3 p., 22963.

Research output: Contribution to journalArticle

Anti-Inflammatory Agents
Pancreatic Elastase
Skeleton
Superoxides
Nuclear magnetic resonance
8 Citations (Scopus)

UV-guided isolation of polyynes and polyenes from the roots of Codonopsis pilosula

Chao, C. H., Juang, S. H., Chan, H. H., Shen, D. Y., Liao, Y. R., Shih, H. C., Huang, C. H., Cheng, J. C., Chen, F. A., Hung, H-Y. & Wu, T-S., 2015 Jan 1, In : RSC Advances. 5, 52, p. 41324-41331 8 p.

Research output: Contribution to journalArticle

Polyacetylenes
Polyenes
Dichroism
Assays
Nuclear magnetic resonance
13 Citations (Scopus)

γ- and δ-Lactams from the Leaves of Clausena lansium

Shen, D. Y., Nguyen, T. N., Wu, S. J., Shiao, Y. J., Hung, H-Y., Kuo, P-C., Kuo, D. H., Thang, T. D. & Wu, T-S., 2015 Nov 25, In : Journal of Natural Products. 78, 11, p. 2521-2530 10 p.

Research output: Contribution to journalArticle

Clausena
Lactams
Cell death
Circular Dichroism
Amides
2014
8 Citations (Scopus)

A-ring modified betulinic acid derivatives as potent cancer preventive agents

Hung, H-Y., Nakagawa-Goto, K., Tokuda, H., Iida, A., Suzuki, N., Bori, I. D., Qian, K. & Lee, K. H., 2014 Feb 1, In : Bioorganic and Medicinal Chemistry Letters. 24, 3, p. 1005-1008 4 p.

Research output: Contribution to journalArticle

Tetradecanoylphorbol Acetate
Acetates
Curcumin
Derivatives
Assays
36 Citations (Scopus)

Design, synthesis, mechanisms of action, and toxicity of novel 20(s)-sulfonylamidine derivatives of camptothecin as potent antitumor agents

Wang, M. J., Liu, Y. Q., Chang, L. C., Wang, C. Y., Zhao, Y. L., Zhao, X. B., Qian, K., Nan, X., Yang, L., Yang, X. M., Hung, H-Y., Yang, J. S., Kuo, D. H., Goto, M., Morris-Natschke, S. L., Pan, S. L., Teng, C. M., Kuo, S. C., Wu, T-S., Wu, Y. C. & 1 others, Lee, K. H., 2014 Jul 24, In : Journal of Medicinal Chemistry. 57, 14, p. 6008-6018 11 p.

Research output: Contribution to journalArticle

Camptothecin
Type I DNA Topoisomerase
irinotecan
Lethal Dose 50
Antineoplastic Agents
14 Citations (Scopus)

YC-1 inhibits proliferation of breast cancer cells by down-regulating EZH2 expression via activation of c-Cbl and ERK

Chang, L. C., Lin, H. Y., Tsai, M. T., Chou, R. H., Lee, F. Y., Teng, C. M., Hsieh, M. T., Hung, H-Y., Huang, L. J., Yu, Y. L. & Kuo, S. C., 2014 Jan 1, In : British Journal of Pharmacology. 171, 17, p. 4010-4025 16 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Heterografts
Down-Regulation
Apoptosis
Triple Negative Breast Neoplasms
2013
5 Citations (Scopus)
Artemisia
Chinese Traditional Medicine
Pharmacology
Liver
2012
1 Citation (Scopus)

1-(3,4,5-Trimethoxyphenyl)ethane-1,2-diyl esters, a novel compound class with potent chemoreversal activity

Hung, H-Y., Ohkoshi, E., Goto, M., Nakagawa-Goto, K. & Lee, K. H., 2012 Dec 15, In : Bioorganic and Medicinal Chemistry Letters. 22, 24, p. 7726-7729 4 p.

Research output: Contribution to journalArticle

Ethane
Vincristine
Verapamil
Esters
Chromones
49 Citations (Scopus)

Anti-AIDS agents 88. Anti-HIV conjugates of betulin and betulinic acid with AZT prepared via click chemistry

Bori, I. D., Hung, H-Y., Qian, K., Chen, C. H., Morris-Natschke, S. L. & Lee, K. H., 2012 Apr 11, In : Tetrahedron Letters. 53, 15, p. 1987-1989 3 p.

Research output: Contribution to journalArticle

Click Chemistry
Anti-HIV Agents
HIV
Triterpenes
Triazoles
24 Citations (Scopus)

Antitumor agents. 293. Nontoxic dimethyl-4,4′-dimethoxy-5,6,5′, 6′-dimethylenedioxybiphenyl-2,2′-dicarboxylate (DDB) analogues chemosensitize multidrug-resistant cancer cells to clinical anticancer drugs

Hung, H-Y., Ohkoshi, E., Goto, M., Bastow, K. F., Nakagawa-Goto, K. & Lee, K. H., 2012 Jun 14, In : Journal of Medicinal Chemistry. 55, 11, p. 5413-5424 12 p.

Research output: Contribution to journalArticle

P-Glycoprotein
Vincristine
Antineoplastic Agents
Verapamil
Doxorubicin
3 Citations (Scopus)

Cancer preventive agents 11. Novel analogs of dimethyl dicarboxylate biphenyl as potent cancer chemopreventive agents

Hung, H-Y., Nakagawa-Goto, K., Tokuda, H., Iida, A., Suzuki, N., Morris-Natschke, S. L. & Lee, K. H., 2012 Jan 1, In : Pharmaceutical Biology. 50, 1, p. 18-24 7 p.

Research output: Contribution to journalArticle

Tetradecanoylphorbol Acetate
Carcinogenicity Tests
Neoplasms
Skin Tests
9,10-Dimethyl-1,2-benzanthracene
21 Citations (Scopus)

Design and synthesis of diarylamines and diarylethers as cytotoxic antitumor agents

Wang, X. F., Tian, X. T., Ohkoshi, E., Qin, B., Liu, Y. N., Wu, P. C., Hour, M. J., Hung, H-Y., Qian, K., Huang, R., Bastow, K. F., Janzen, W. P., Jin, J., Morris-Natschke, S. L., Lee, K. H. & Xie, L., 2012 Oct 1, In : Bioorganic and Medicinal Chemistry Letters. 22, 19, p. 6224-6228 5 p.

Research output: Contribution to journalArticle

Cytotoxins
Antineoplastic Agents
Protein-Tyrosine Kinases
Tumors
Proto-Oncogenes
137 Citations (Scopus)

Recent discovery of plant-derived anti-diabetic natural products

Hung, H-Y., Qian, K., Morris-Natschke, S. L., Hsu, C. S. & Lee, K. H., 2012 May 1, In : Natural Product Reports. 29, 5, p. 580-606 27 p.

Research output: Contribution to journalReview article

Medical problems
Biological Products
Type 2 Diabetes Mellitus
Literature
Patents
2011
36 Citations (Scopus)

New betulinic acid derivatives as potent proteasome inhibitors

Qian, K., Kim, S. Y., Hung, H-Y., Huang, L., Chen, C. H. & Lee, K. H., 2011 Oct 1, In : Bioorganic and Medicinal Chemistry Letters. 21, 19, p. 5944-5947 4 p.

Research output: Contribution to journalArticle

Proteasome Inhibitors
Proteasome Endopeptidase Complex
Derivatives
Chymotrypsin
betulinic acid
2010
20 Citations (Scopus)

Antitumor agents. 280. Multidrug resistance-selective desmosdumotin B analogues

Nakagawa-Goto, K., Chang, P. C., Lai, C. Y., Hung, H-Y., Chen, T. H., Wu, P. C., Zhu, H., Sedykh, A., Bastow, K. F. & Lee, K. H., 2010 Sep 23, In : Journal of Medicinal Chemistry. 53, 18, p. 6699-6705 7 p.

Research output: Contribution to journalArticle

Multiple Drug Resistance
P-Glycoprotein
Antineoplastic Agents
KB Cells
Verapamil