• 587 Citations
  • 14 h-Index
20102019

Research output per year

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Research Output

  • 587 Citations
  • 14 h-Index
  • 45 Article
  • 2 Review article
  • 1 Comment/debate
  • 1 Letter
2019

Bioassay-guided purification of sesquiterpenoids from the fruiting bodies of: Fomitopsis pinicola and their anti-inflammatory activity

Tai, S. H., Kuo, P. C., Hung, C. C., Lin, Y. H., Hwang, T. L., Lam, S. H., Kuo, D. H., Wu, J. B., Hung, H. Y. & Wu, T. S., 2019 Jan 1, In : RSC Advances. 9, 59, p. 34184-34195 12 p.

Research output: Contribution to journalArticle

Open Access
Open Access

Chemical constituents from the stems of Machilus philippinensis Merr. and the neuroprotective activity of cinnamophilin

Tai, S. H., Kuo, P. C., Lam, S. H., Huang, S. C., Kuo, Y. Z., Hung, H. Y., Liou, M. J., Shieh, P. C., Lee, E. J. & Wu, T. S., 2019 Jan 1, In : RSC Advances. 9, 38, p. 21616-21625 10 p.

Research output: Contribution to journalArticle

Open Access

Constituents and anti-multidrug resistance activity of taiwanofungus camphoratus on human cervical cancer cells

Hung, H. Y., Hung, C. C., Liang, J. W., Chen, C. F., Chen, H. Y., Shieh, P. C., Kuo, P. C. & Wu, T. S., 2019 Oct 16, In : Molecules. 24, 20, 3730.

Research output: Contribution to journalArticle

Open Access

Zhankuic acids A, B and C from taiwanofungus camphoratus act as cytotoxicity enhancers by regulating p-glycoprotein in multi-drug resistant cancer cells

Teng, Y. N., Wang, Y. H., Wu, T. S., Hung, H. Y. & Hung, C. C., 2019 Dec, In : Biomolecules. 9, 12, 759.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)
2018

A feasible and practical 1H NMR analytical method for the quality control and quantification of bioactive principles in Lycii Fructus

Hsieh, L. Y., Chan, H. H., Kuo, P. C., Hung, H. Y., Li, Y. C., Kuo, C. L., Peng, Y., Zhao, Z. Z., Kuo, D. H., Sun, I. W. & Wu, T. S., 2018 Jul, In : Journal of Food and Drug Analysis. 26, 3, p. 1105-1112 8 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Chemical constituents from the stems of tinospora sinensis and their bioactivity

Lam, S. H., Chen, P. H., Hung, H. Y., Hwang, T. L., Chiang, C. C., Thang, T. D., Kuo, P. C. & Wu, T. S., 2018 Oct 5, In : Molecules. 23, 10, 2541.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Hepatoprotective Principles and Other Chemical Constituents from the Mycelium of Phellinus linteus

Huang, S. C., Wang, P. W., Kuo, P. C., Hung, H. Y. & Pan, T. L., 2018 Jul 12, In : Molecules (Basel, Switzerland). 23, 7

Research output: Contribution to journalArticle

1 Citation (Scopus)

Melatonin protects brain against ischemia/reperfusion injury by attenuating endoplasmic reticulum stress

Lin, Y. W., Chen, T. Y., Hung, C. Y., Tai, S. H., Huang, S. Y., Chang, C. C., Hung, H. Y. & Lee, E. J., 2018 Jul, In : International journal of molecular medicine. 42, 1, p. 182-192 11 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)
3 Citations (Scopus)

The constituents of the stems of cissus assamica and their bioactivities

Chan, Y. Y., Wang, C. Y., Hwang, T. L., Juang, S. H., Hung, H. Y., Kuo, P. C., Chen, P. J. & Wu, T. S., 2018 Oct 28, In : Molecules. 23, 11, 23112799.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Therapeutic window for YC-1 following glutamate-induced neuronal damage and transient focal cerebral ischemia

Tai, S. H., Lee, W. T., Lee, A. C., Lin, Y. W., Hung, H. Y., Huang, S. Y., Wu, T. S. & Lee, E. J., 2018 May, In : Molecular Medicine Reports. 17, 5, p. 6490-6496 7 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2017

Anti-inflammatory and neuroprotective constituents from the peels of citrus grandis

Kuo, P. C., Liao, Y. R., Hung, H. Y., Chuang, C. W., Hwang, T. L., Huang, S. C., Shiao, Y. J., Kuo, D. H. & Wu, T. S., 2017 Jun, In : Molecules. 22, 6, 967.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Anti-inflammatory Flavan-3-ol-dihydroretrochalcones from Daemonorops draco

Kuo, P. C., Hung, H. Y., Hwang, T. L., Du, W. K., Ku, H. C., Lee, E. J., Tai, S. H., Chen, F. A. & Wu, T. S., 2017 Apr 28, In : Journal of Natural Products. 80, 4, p. 783-789 7 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Characterization of cyclodepsipeptides from the mycelium of Isaria Japonica from Vietnam

Tuan, N. N., Ngan, N. T., Kuo, P-C., Hung, H-Y., Lan, T. N., Thanh, N. T., Xuan, D. T. T., Thang, T. D. & Wu, T-S., 2017 Jan 1, In : Natural Product Communications. 12, 3, p. 377-378 2 p.

Research output: Contribution to journalArticle

Chemical Constituents and Anti-inflammatory Principles from the Fruits of Forsythia suspensa

Kuo, P. C., Hung, H. Y., Nian, C. W., Hwang, T. L., Cheng, J. C., Kuo, D. H., Lee, E. J., Tai, S. H. & Wu, T. S., 2017 Apr 28, In : Journal of Natural Products. 80, 4, p. 1055-1064 10 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)
1 Citation (Scopus)

New bis(hydroxymethyl) alkanoate curcuminoid derivatives exhibit activity against triple-negative breast cancer in vitro and in vivo

Hsieh, M. T., Chang, L. C., Hung, H. Y., Lin, H. Y., Shih, M. H., Tsai, C. H., Kuo, S. C. & Lee, K. H., 2017 Jan 1, In : European Journal of Medicinal Chemistry. 131, p. 141-151 11 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Synthesis and biological evaluation of chalcone, dihydrochalcone, and 1,3-diarylpropane analogs as anti-inflammatory agents

Vijaya Bhaskar Reddy, M., Hung, H. Y., Kuo, P. C., Huang, G. J., Chan, Y. Y., Huang, S. C., Wu, S. J., Morris-Natschke, S. L., Lee, K. H. & Wu, T. S., 2017 Jan 1, In : Bioorganic and Medicinal Chemistry Letters. 27, 7, p. 1547-1550 4 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)
2016

A novel microtubule inhibitor, MT3-037, causes cancer cell apoptosis by inducing mitotic arrest and interfering with microtubule dynamics

Chang, L. C., Yu, Y. L., Hsieh, M. T., Wang, S. H., Chou, R. H., Huang, W. C., Lin, H. Y., Hung, H. Y., Huang, L. J. & Kuo, S. C., 2016 Jan 1, In : American Journal of Cancer Research. 6, 4, p. 747-763 17 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Anti-inflammatory neolignans from the roots of Magnolia officinalis

Shih, H. C., Kuo, P. C., Wu, S. J., Hwang, T. L., Hung, H. Y., Shen, D. Y., Shieh, P. C., Liao, Y. R., Lee, E. J., Gu, Q., Lee, K. H. & Wu, T. S., 2016 Apr 1, In : Bioorganic and Medicinal Chemistry. 24, 7, p. 1439-1445 7 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Application of flow cytometry for evaluating clinical prognosis and histopathological grade of human glioma

Lin, Y. W., Tai, S. H., Chang, C. C., Chao, L. C., Wen, M. J., Huang, Y. H., Hung, H. Y. & Lee, E. J., 2016 Apr 21, In : Neurological Research. 38, 7, p. 625-633 9 p.

Research output: Contribution to journalArticle

A rapid quantitative 1H NMR analysis of kinsenoside and other bioactive principles from: Anoectochilus formosanus

Hsieh, L. Y., Chan, H. H., Hung, H-Y., Kuo, C. L., Wu, J. B., Sun, I-W., Kuo, P-C. & Wu, T-S., 2016 Jul 28, In : Analytical Methods. 8, 28, p. 5645-5650 6 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Chemical Constituents of the Rhizomes of Bletilla formosana and Their Potential Anti-inflammatory Activity

Lin, C. W., Hwang, T. L., Chen, F. A., Huang, C. H., Hung, H. Y. & Wu, T. S., 2016 Aug 26, In : Journal of Natural Products. 79, 8, p. 1911-1921 11 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Erratum: Dragonbloodin A1 and A2: Flavan Trimers and Anti-inflammatory Principles from Sanguis Draconis (Organic Letters)

Du, W. K., Hung, H. Y., Kuo, P. C., Hwang, T. L., Shiu, L. C., Shiu, K. B., Lee, E. J., Tai, S. H. & Wu, T. S., 2016 Jun 17, In : Organic Letters. 18, 12, 1 p.

Research output: Contribution to journalComment/debate

6 Citations (Scopus)

Four new compounds from edible algae Cladosiphon okamuranus and Chlorella sorokiniana and their bioactivities

Cheng, K. C., Kuo, P. C., Hung, H. Y., Yu, K. H., Hwang, T. L., Shieh, P. C., Chang, J. S. & Wu, T. S., 2016 Dec 1, In : Phytochemistry Letters. 18, p. 113-116 4 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Ionone derivatives from the mycelium of Phellinus linteus and the inhibitory effect on activated rat hepatic stellate cells

Huang, S. C., Kuo, P. C., Hung, H. Y., Pan, T. L., Chen, F. A. & Wu, T. S., 2016 May 6, In : International journal of molecular sciences. 17, 5, 681.

Research output: Contribution to journalLetter

3 Citations (Scopus)

Recent progress on the traditional Chinese medicines that regulate the blood

Hung, H. Y. & Wu, T. S., 2016 Apr 1, In : Journal of Food and Drug Analysis. 24, 2, p. 221-238 18 p.

Research output: Contribution to journalReview article

16 Citations (Scopus)

Synthesis and characterization of 3-arylidenechroman-4-ones and their inhibitory effects on platelet aggregation activity

Reddy, M. V. B., Kuo, P. C., Hung, H. Y., Tsai, W. J. & Wu, T. S., 2016 Jan 1, In : Der Pharmacia Lettre. 8, 20, p. 14-20 7 p.

Research output: Contribution to journalArticle

2015
4 Citations (Scopus)

New benzenoids from the roots of lindera aggregata

Ma, G. H., Lin, C. W., Hung, H-Y., Wang, S. Y., Shieh, P. C. & Wu, T-S., 2015 Jan 1, In : Natural Product Communications. 10, 12, p. 2131-2133 3 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Novel curcumin analogs to overcome EGFR-TKI lung adenocarcinoma drug resistance and reduce EGFR-TKI-induced GI adverse effects

Wada, K., Lee, J. Y., Hung, H. Y., Shi, Q., Lin, L., Zhao, Y., Goto, M., Yang, P. C., Kuo, S. C., Chen, H. W. & Lee, K. H., 2015 Apr 1, In : Bioorganic and Medicinal Chemistry. 23, 7, p. 1507-1514 8 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Novel Pyrazole Derivatives Effectively Inhibit Osteoclastogenesis, a Potential Target for Treating Osteoporosis

Kuo, T. H., Lin, T. H., Yang, R. S., Kuo, S. C., Fu, W. M. & Hung, H-Y., 2015 Jun 25, In : Journal of Medicinal Chemistry. 58, 12, p. 4954-4963 10 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

The newly synthesized 2-arylnaphthyridin-4-one, CSC-3436, induces apoptosis of non-small cell lung cancer cells by inhibiting tubulin dynamics and activating CDK1

Chang, L. C., Yu, Y. L., Liu, C. Y., Cheng, Y. Y., Chou, R. H., Hsieh, M. T., Lin, H. Y., Hung, H. Y., Huang, L. J., Wu, Y. C. & Kuo, S. C., 2015 Jun 26, In : Cancer Chemotherapy and Pharmacology. 75, 6, p. 1303-1315 13 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Total synthesis of cordatanine, structural reassignment of drymaritin, and anti-inflammatory activity of synthetic precursor

Fang, H. W., Liao, Y. R., Hwang, T. L., Shieh, P. C., Lee, K. H., Hung, H. Y. & Wu, T. S., 2015 Aug 17, In : Bioorganic and Medicinal Chemistry Letters. 25, 18, p. 3822-3824 3 p., 22963.

Research output: Contribution to journalArticle

2 Citations (Scopus)

UV-guided isolation of polyynes and polyenes from the roots of Codonopsis pilosula

Chao, C. H., Juang, S. H., Chan, H. H., Shen, D. Y., Liao, Y. R., Shih, H. C., Huang, C. H., Cheng, J. C., Chen, F. A., Hung, H-Y. & Wu, T-S., 2015 Jan 1, In : RSC Advances. 5, 52, p. 41324-41331 8 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

γ- and δ-Lactams from the Leaves of Clausena lansium

Shen, D. Y., Nguyen, T. N., Wu, S. J., Shiao, Y. J., Hung, H-Y., Kuo, P-C., Kuo, D. H., Thang, T. D. & Wu, T-S., 2015 Nov 25, In : Journal of Natural Products. 78, 11, p. 2521-2530 10 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)
2014

A-ring modified betulinic acid derivatives as potent cancer preventive agents

Hung, H. Y., Nakagawa-Goto, K., Tokuda, H., Iida, A., Suzuki, N., Bori, I. D., Qian, K. & Lee, K. H., 2014 Feb 1, In : Bioorganic and Medicinal Chemistry Letters. 24, 3, p. 1005-1008 4 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Design, synthesis, mechanisms of action, and toxicity of novel 20(s)-sulfonylamidine derivatives of camptothecin as potent antitumor agents

Wang, M. J., Liu, Y. Q., Chang, L. C., Wang, C. Y., Zhao, Y. L., Zhao, X. B., Qian, K., Nan, X., Yang, L., Yang, X. M., Hung, H. Y., Yang, J. S., Kuo, D. H., Goto, M., Morris-Natschke, S. L., Pan, S. L., Teng, C. M., Kuo, S. C., Wu, T. S., Wu, Y. C. & 1 others, Lee, K. H., 2014 Jul 24, In : Journal of Medicinal Chemistry. 57, 14, p. 6008-6018 11 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)

YC-1 inhibits proliferation of breast cancer cells by down-regulating EZH2 expression via activation of c-Cbl and ERK

Chang, L. C., Lin, H. Y., Tsai, M. T., Chou, R. H., Lee, F. Y., Teng, C. M., Hsieh, M. T., Hung, H. Y., Huang, L. J., Yu, Y. L. & Kuo, S. C., 2014 Sep, In : British Journal of Pharmacology. 171, 17, p. 4010-4025 16 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)
2013
5 Citations (Scopus)
2012

1-(3,4,5-Trimethoxyphenyl)ethane-1,2-diyl esters, a novel compound class with potent chemoreversal activity

Hung, H-Y., Ohkoshi, E., Goto, M., Nakagawa-Goto, K. & Lee, K. H., 2012 Dec 15, In : Bioorganic and Medicinal Chemistry Letters. 22, 24, p. 7726-7729 4 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Anti-AIDS agents 88. Anti-HIV conjugates of betulin and betulinic acid with AZT prepared via click chemistry

Bori, I. D., Hung, H. Y., Qian, K., Chen, C. H., Morris-Natschke, S. L. & Lee, K. H., 2012 Apr 11, In : Tetrahedron Letters. 53, 15, p. 1987-1989 3 p.

Research output: Contribution to journalArticle

51 Citations (Scopus)

Antitumor agents. 293. Nontoxic dimethyl-4,4′-dimethoxy-5,6,5′, 6′-dimethylenedioxybiphenyl-2,2′-dicarboxylate (DDB) analogues chemosensitize multidrug-resistant cancer cells to clinical anticancer drugs

Hung, H. Y., Ohkoshi, E., Goto, M., Bastow, K. F., Nakagawa-Goto, K. & Lee, K. H., 2012 Jun 14, In : Journal of Medicinal Chemistry. 55, 11, p. 5413-5424 12 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Cancer preventive agents 11. Novel analogs of dimethyl dicarboxylate biphenyl as potent cancer chemopreventive agents

Hung, H-Y., Nakagawa-Goto, K., Tokuda, H., Iida, A., Suzuki, N., Morris-Natschke, S. L. & Lee, K. H., 2012 Jan 1, In : Pharmaceutical Biology. 50, 1, p. 18-24 7 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Design and synthesis of diarylamines and diarylethers as cytotoxic antitumor agents

Wang, X. F., Tian, X. T., Ohkoshi, E., Qin, B., Liu, Y. N., Wu, P. C., Hour, M. J., Hung, H-Y., Qian, K., Huang, R., Bastow, K. F., Janzen, W. P., Jin, J., Morris-Natschke, S. L., Lee, K. H. & Xie, L., 2012 Oct 1, In : Bioorganic and Medicinal Chemistry Letters. 22, 19, p. 6224-6228 5 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Recent discovery of plant-derived anti-diabetic natural products

Hung, H-Y., Qian, K., Morris-Natschke, S. L., Hsu, C. S. & Lee, K. H., 2012 May 1, In : Natural Product Reports. 29, 5, p. 580-606 27 p.

Research output: Contribution to journalReview article

144 Citations (Scopus)
2011

New betulinic acid derivatives as potent proteasome inhibitors

Qian, K., Kim, S. Y., Hung, H. Y., Huang, L., Chen, C. H. & Lee, K. H., 2011 Oct 1, In : Bioorganic and Medicinal Chemistry Letters. 21, 19, p. 5944-5947 4 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)
2010

Antitumor agents. 280. Multidrug resistance-selective desmosdumotin B analogues

Nakagawa-Goto, K., Chang, P. C., Lai, C. Y., Hung, H. Y., Chen, T. H., Wu, P. C., Zhu, H., Sedykh, A., Bastow, K. F. & Lee, K. H., 2010 Sep 23, In : Journal of Medicinal Chemistry. 53, 18, p. 6699-6705 7 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)