HsuehCheng Chinag

Assistant Professor

  • 1713 Citations
  • 18 h-Index
20042020
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Research Output 2004 2019

  • 1713 Citations
  • 18 h-Index
  • 22 Article
  • 3 Comment/debate
  • 1 Review article
2019

Aging-induced Akt activation involves in aging-related pathologies and Aβ-induced toxicity

Chen, Y. R., Li, Y. H., Hsieh, T. C., Wang, C. M., Cheng, K. C., Wang, L., Lin, T. Y., Cheung, C-H., Wu, C. L. & Chinag, H., 2019 Aug 1, In : Aging Cell. 18, 4, e12989.

Research output: Contribution to journalArticle

Open Access
Alzheimer Disease
Pathology
Diptera
Behavioral Genetics
Amyloid Precursor Protein Secretases

Electrical synapses between mushroom body neurons are critical for consolidated memory retrieval in Drosophila

Shyu, W. H., Lee, W. P., Chiang, M. H., Chang, C. C., Fu, T. F., Chinag, H., Wu, T. & Wu, C. L., 2019 May 1, In : PLoS genetics. 15, 5, p. e1008153

Research output: Contribution to journalArticle

Open Access
Electrical Synapses
Mushroom Bodies
mushroom bodies
mushroom
synapse
2018

Correction: Dysfunction of different cellular degradation pathways contributes to specific β-amyloid42-induced pathologies (FASEB Journal (2018) 32 (1375-1387) DOI: 10.1096/fj.201700199RR)

Ji, X. R., Cheng, K. C., Chen, Y. R., Lin, T. Y., Cheung, C-H., Wu, C. L. & Chinag, H., 2018 Nov 1, In : FASEB Journal. 32, 11, 1 p.

Research output: Contribution to journalComment/debate

Pathology
Taiwan
Medicine
Degradation
Biochemistry

Dysfunction of different cellular degradation pathways contributes to specific β-amyloid42-induced pathologies

Ji, X. R., Cheng, K. C., Chen, Y. R., Lin, T. Y., Cheung, C-H., Wu, C. L. & Chinag, H., 2018 Mar 1, In : FASEB Journal. 32, 3, p. 1375-1387 13 p.

Research output: Contribution to journalArticle

Autophagy
Pathology
Proteasome Endopeptidase Complex
Ubiquitin
Alzheimer Disease
2 Citations (Scopus)

Mushroom body glycolysis is required for olfactory memory in Drosophila

Wu, C. L., Chang, C. C., Wu, J. K., Chiang, M. H., Yang, C. H. & Chinag, H., 2018 Apr 1, In : Neurobiology of Learning and Memory. 150, p. 13-19 7 p.

Research output: Contribution to journalArticle

Mushroom Bodies
Glycolysis
Drosophila
Pyruvate Kinase
Phosphofructokinases
25 Citations (Scopus)

Visualization of Membrane Pore in Live Cells Reveals a Dynamic-Pore Theory Governing Fusion and Endocytosis

Shin, W., Ge, L., Arpino, G., Villarreal, S. A., Hamid, E., Liu, H., Zhao, W. D., Wen, P. J., Chinag, H. & Wu, L. G., 2018 May 3, In : Cell. 173, 4, p. 934-945.e12

Research output: Contribution to journalArticle

Endocytosis
Fusion reactions
Visualization
Constriction
Membranes
1 Citation (Scopus)

XBP1 and PERK Have Distinct Roles in Aβ-Induced Pathology

Cheng, K. C. & Chinag, H., 2018 Sep 1, In : Molecular Neurobiology. 55, 9, p. 7523-7532 10 p.

Research output: Contribution to journalArticle

Endoplasmic Reticulum Stress
Pathology
Learning
Proteasome Endopeptidase Complex
Diptera
2016
50 Citations (Scopus)

Actin dynamics provides membrane tension to merge fusing vesicles into the plasma membrane

Wen, P. J., Grenklo, S., Arpino, G., Tan, X., Liao, H. S., Heureaux, J., Peng, S. Y., Chinag, H., Hamid, E., Zhao, W. D., Shin, W., Näreoja, T., Evergren, E., Jin, Y., Karlsson, R., Ebert, S. N., Jin, A., Liu, A. P., Shupliakov, O. & Wu, L. G., 2016 Aug 31, In : Nature communications. 7, 12604.

Research output: Contribution to journalArticle

Neuroendocrine Cells
Cell membranes
Endocytosis
Merging
Actins
48 Citations (Scopus)

Hemi-fused structure mediates and controls fusion and fission in live cells

Zhao, W. D., Hamid, E., Shin, W., Wen, P. J., Krystofiak, E. S., Villarreal, S. A., Chinag, H., Kachar, B. & Wu, L. G., 2016 Jun 15, In : Nature. 534, 7608, p. 548-552 5 p.

Research output: Contribution to journalArticle

Observation
Dynamins
Neuroendocrine Cells
Porins
Chromaffin Cells
2015

Erratum: Post-fusion structural changes and their roles in exocytosis and endocytosis of dense-core vesicles (Nature Communications (2014) 5 (3356) DOI:10.1038/ncomms4356)

Chinag, H., Shin, W., Zhao, W. D., Hamid, E., Sheng, J., Baydyuk, M., Wen, P. J., Jin, A., Momboisse, F. & Wu, L. G., 2015 Jan 1, In : Nature communications. 6, 6016.

Research output: Contribution to journalComment/debate

2014
81 Citations (Scopus)

Erratum: Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis

Cai, Z., Jitkaew, S., Zhao, J., Chinag, H., Choksi, S., Liu, J., Ward, Y., Wu, L. G. & Liu, Z. G., 2014 Feb 1, In : Nature Cell Biology. 16, 2, 1 p.

Research output: Contribution to journalComment/debate

Cell Membrane
Proteins
143 Citations (Scopus)

Exocytosis and endocytosis: Modes, functions, and coupling mechanisms*

Wu, L. G., Hamid, E., Shin, W. & Chinag, H., 2014 Feb 1, In : Annual Review of Physiology. 76, p. 301-331 31 p.

Research output: Contribution to journalReview article

Exocytosis
Endocytosis
Calcium
R-SNARE Proteins
Synaptotagmins
356 Citations (Scopus)

Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis

Cai, Z., Jitkaew, S., Zhao, J., Chinag, H., Choksi, S., Liu, J., Ward, Y., Wu, L. G. & Liu, Z. G., 2014 Jan 1, In : Nature Cell Biology. 16, 1, p. 55-65 11 p.

Research output: Contribution to journalArticle

Phosphotransferases
Tumor Necrosis Factor-alpha
Cell Membrane
Receptor-Interacting Protein Serine-Threonine Kinases
Proteins
40 Citations (Scopus)

Post-fusion structural changes and their roles in exocytosis and endocytosis of dense-core vesicles

Chinag, H., Shin, W., Zhao, W. D., Hamid, E., Sheng, J., Baydyuk, M., Wen, P. J., Jin, A., Momboisse, F. & Wu, L. G., 2014 Feb 24, In : Nature communications. 5, 4356.

Research output: Contribution to journalArticle

Exocytosis
Secretory Vesicles
Endocytosis
Fusion reactions
Cell membranes
2013
16 Citations (Scopus)

Most vesicles in a central nerve terminal participate in recycling

Xue, L., Sheng, J., Wu, X. S., Wu, W., Luo, F., Shin, W., Chinag, H. & Wu, L. G., 2013 May 15, In : Journal of Neuroscience. 33, 20, p. 8820-8826 7 p.

Research output: Contribution to journalArticle

Recycling
Synaptic Transmission
Coloring Agents
Synapses
Glutamic Acid
50 Citations (Scopus)

SNARE Proteins Synaptobrevin, SNAP-25, and Syntaxin Are Involved in Rapid and Slow Endocytosis at Synapses

Xu, J., Luo, F., Zhang, Z., Xue, L., Wu, X. S., Chinag, H., Shin, W. & Wu, L. G., 2013 May 30, In : Cell Reports. 3, 5, p. 1414-1421 8 p.

Research output: Contribution to journalArticle

R-SNARE Proteins
Qa-SNARE Proteins
SNARE Proteins
Endocytosis
Synapses
35 Citations (Scopus)

The SNARE proteins SNAP25 and synaptobrevin are involved in endocytosis at hippocampal synapses

Zhang, Z., Wang, D., Sun, T., Xu, J., Chinag, H., Shin, W. & Wu, L. G., 2013 May 22, In : Journal of Neuroscience. 33, 21, p. 9169-9175 7 p.

Research output: Contribution to journalArticle

N-Ethylmaleimide-Sensitive Proteins
Synaptosomal-Associated Protein 25
R-SNARE Proteins
Endocytosis
Synapses
2012
71 Citations (Scopus)

Epidermal growth factor receptor is a preferred target for treating Amyloid-β-induced memory loss

Wang, L., Chinag, H., Wu, W., Liang, B., Xie, Z., Yao, X., Ma, W., Du, S. & Zhong, Y., 2012 Oct 9, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 41, p. 16743-16748 6 p.

Research output: Contribution to journalArticle

Memory Disorders
Epidermal Growth Factor Receptor
Amyloid
Neuronal Plasticity
Diptera
2010
64 Citations (Scopus)

PI3 kinase signaling is involved in Aβ-induced memory loss in Drosophila

Chinag, H., Wang, L., Xie, Z., Yau, A. & Zhong, Y., 2010 Apr 13, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 15, p. 7060-7065 6 p.

Research output: Contribution to journalArticle

Memory Disorders
Phosphatidylinositol 3-Kinases
Drosophila
Alzheimer Disease
Depression
2009
20 Citations (Scopus)

Distinctive roles of different β-amyloid 42 aggregates in modulation of synaptic functions

Chinag, H., Iijima, K., Hakker, I. & Zhong, Y., 2009 Jun 1, In : FASEB Journal. 23, 6, p. 1969-1977 9 p.

Research output: Contribution to journalArticle

Amyloid
Modulation
Synaptic Transmission
Neurotransmitter Agents
Oligomers
2008
108 Citations (Scopus)

Aβ42 mutants with different aggregation profiles induce distinct pathologies in Drosophila

Iijima, K., Chinag, H., Hearn, S. A., Hakker, I., Gatt, A., Shenton, C., Granger, L., Leung, A., Iijima-Ando, K. & Zhong, Y., 2008 Feb 27, In : PLoS ONE. 3, 2, e1703.

Research output: Contribution to journalArticle

Pathology
amyloid
Amyloid
Drosophila
Agglomeration
61 Citations (Scopus)
Neprilysin
Premature Mortality
Amyloid Plaques
Pathology
Transcription
2006
59 Citations (Scopus)

Amyotrophic lateral sclerosis 2-deficiency leads to neuronal degeneration in amyotrophic lateral sclerosis through altered AMPA receptor trafficking

Lai, C., Xie, C., McCormack, S. G., Chinag, H., Michalak, M. K., Lin, X., Chandran, J., Shim, H., Shimoji, M., Cookson, M. R., Huganir, R. L., Rothstein, J. D., Price, D. L., Wong, P. C., Martin, L. J., Zhu, J. J. & Cai, H., 2006 Nov 8, In : Journal of Neuroscience. 26, 45, p. 11798-11806 9 p.

Research output: Contribution to journalArticle

AMPA Receptors
Amyotrophic Lateral Sclerosis
Glutamate Receptors
Receptor-Interacting Protein Serine-Threonine Kinases
Motor Neurons
2005
378 Citations (Scopus)

BACE1, a major determinant of selective vulnerability of the brain to amyloid-β amyloidogenesis, is essential for cognitive, emotional, and synaptic functions

Laird, F. M., Cai, H., Savonenko, A. V., Farah, M. H., He, K., Melnikova, T., Wen, H., Chinag, H., Xu, G., Koliatsos, V. E., Borchelt, D. R., Price, D. L., Lee, H. K. & Wong, P. C., 2005 Dec 14, In : Journal of Neuroscience. 25, 50, p. 11693-11709 17 p.

Research output: Contribution to journalArticle

Amyloid beta-Protein Precursor
Amyloid
Amyloidosis
Neurons
Alzheimer Disease
87 Citations (Scopus)

Loss of ALS2 function is insufficient to trigger motor neuron degeneration in knock-out mice but predisposes neurons to oxidative stress

Cai, H., Lin, X., Xie, C., Laird, F. M., Lai, C., Wen, H., Chinag, H., Shim, H., Farah, M. H., Hoke, A., Price, D. L. & Wong, P. C., 2005 Aug 17, In : Journal of Neuroscience. 25, 33, p. 7567-7574 8 p.

Research output: Contribution to journalArticle

Nerve Degeneration
Motor Neurons
Knockout Mice
Oxidative Stress
Neurons
2004
18 Citations (Scopus)

Synergistic effects of dopamine and Zn 2+ on the induction of PC12 cell death and dopamine depletion in the striatum: Possible implication in the pathogenesis of Parkinson's disease

Lo, H. S., Chinag, H., Lin, A. M. Y., Chiang, H. Y., Chu, Y. C. & Kao, L. S., 2004 Oct 1, In : Neurobiology of Disease. 17, 1, p. 54-61 8 p.

Research output: Contribution to journalArticle

PC12 Cells
Parkinson Disease
Dopamine
Cell Death
Dopaminergic Neurons