• 1180 Citations
  • 19 h-Index
19962018
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Research Output 1996 2018

  • 1180 Citations
  • 19 h-Index
  • 44 Article
  • 4 Patent
  • 2 Review article
2018
4 Citations (Scopus)

Apoptotic and nonapoptotic activities of pterostilbene against cancer

Chen, R-J., Kuo, H. C., Cheng, L. H., Lee, Y-H., Chang, W-T., Wang, B. J., Wang, Y-J. & Cheng, H-C., 2018 Jan 18, In : International journal of molecular sciences. 19, 1, 287.

Research output: Contribution to journalReview article

Medicine
cancer
Nutrition
Tumors
Neoplasms
5 Citations (Scopus)

Decreased succinate dehydrogenase B in human hepatocellular carcinoma accelerates tumor malignancy by inducing the Warburg effect

Tseng, P. L., Wu, W. H., Hu, T. H., Chen, C. W., Cheng, H. C., Li, C. F., Tsai, W. H., Tsai, H. J., Hsieh, M. C., Chuang, J. H. & Chang, W. T., 2018 Dec 1, In : Scientific reports. 8, 1, 3081.

Research output: Contribution to journalArticle

Succinate Dehydrogenase
Hepatocellular Carcinoma
Neoplasms
Glycolysis
Energy Metabolism
4 Citations (Scopus)

Glycine N-methyltransferase inhibits aristolochic acid nephropathy by increasing CYP3A44 and decreasing NQO1 expression in female mouse hepatocytes

Chang, M. M., Lin, C. N., Fang, C. C., Chen, M., Liang, P. I., Li, W. M., Yeh, B. W., Cheng, H-C., Huang, B-M., Wu, W. J. & Chen, Y. M. A., 2018 Dec 1, In : Scientific reports. 8, 1, 6960.

Research output: Contribution to journalArticle

Glycine N-Methyltransferase
Hepatocytes
Aristolochic Acids
Liver
aristolochic acid I
1 Citation (Scopus)

The decrease of glycolytic enzyme hexokinase 1 accelerates tumor malignancy via deregulating energy metabolism but sensitizes cancer cells to 2-deoxyglucose inhibition

Tseng, P. L., Chen, C. W., Hu, K. H., Cheng, H-C., Lin, Y. H., Tsai, W. H., Cheng, T. J., Wu, W. H., Yeh, C. W., Lin, C. C., Tsai, H. J., Chang, H. C., Chuang, J. H., Shan, Y-S. & Chang, W-T., 2018 Apr 10, In : Oncotarget. 9, 27, p. 18949-18969 21 p.

Research output: Contribution to journalArticle

Hexokinase
Deoxyglucose
Energy Metabolism
Enzymes
Neoplasms

The establishment of a lung colonization assay for circulating tumor cell visualization in lung tissues

Lin, T. C., Liao, Y. C., Chang, W-T., Yang, C. H., Cheng, L. H., Cheng, M. & Cheng, H-C., 2018 Jun 18, In : Journal of Visualized Experiments. 2018, 136, e56761.

Research output: Contribution to journalArticle

Circulating Neoplastic Cells
Tumors
Assays
Visualization
Cells
1 Citation (Scopus)

VAMP8, a vesicle-SNARE required for RAB37-mediated exocytosis, possesses a tumor metastasis suppressor function

Wang, Y., Tzeng, H., Tsai, C., Cheng, H., Lai, W., Liu, H. & Wang, Y., 2018 Nov 1, In : Cancer Letters. 437, p. 79-88

Research output: Contribution to journalArticle

2017
14 Citations (Scopus)

Dysregulation of Rab37-mediated cross-talk between cancer cells and endothelial cells via thrombospondin-1 promotes tumor neovasculature and metastasis

Tzeng, H. T., Tsai, C. H., Yen, Y-T., Cheng, H-C., Chen, Y. C., Pu, S. W., Wang, Y. S., Shan, Y-S., Tseng, Y-L., Su, W-C., Lai, W-W., Wu, L-W. & Wang, Y-C., 2017 May 1, In : Clinical Cancer Research. 23, 9, p. 2335-2345 11 p.

Research output: Contribution to journalArticle

Thrombospondin 1
Endothelial Cells
Neoplasm Metastasis
Tumor Microenvironment
Exocytosis
5 Citations (Scopus)

Increased risk of brain cancer incidence in stroke patients: A clinical case series, population-based and longitudinal follow-up study

Chen, C. W., Cheng, T. J., Ho, C. H., Wang, J. J., Weng, S. F., Hou, Y. C., Cheng, H-C., Chio, C. C., Shan, Y-S. & Chang, W-T., 2017 Jan 1, In : Oncotarget. 8, 65, p. 108989-108999 11 p.

Research output: Contribution to journalArticle

Brain Neoplasms
Stroke
Incidence
Population
Confidence Intervals
9 Citations (Scopus)
Fibronectins
Polymerization
Lung Neoplasms
Lewis Lung Carcinoma
Apoptosis
6 Citations (Scopus)

Ubiquitination of tumor suppressor PML regulates prometastatic and immunosuppressive tumor microenvironment

Wang, Y. T., Chen, J., Chang, C. W., Jen, J., Huang, T. Y., Chen, C. M., Shen, R., Liang, S. Y., Cheng, I. C., Yang, S. C., Lai, W-W., Cheng, K. H., Hsieh, T. S., Lai, M. Z., Cheng, H-C., Wang, Y-C. & Chen, R. H., 2017 Aug 1, In : Journal of Clinical Investigation. 127, 8, p. 2982-2997 16 p.

Research output: Contribution to journalArticle

Tumor Microenvironment
Ubiquitination
Immunosuppressive Agents
Leukemia
Lung Neoplasms
2015
6 Citations (Scopus)

Down-regulation of TIMP-1 inhibits cell migration, invasion, and metastatic colonization in lung adenocarcinoma

Chang, Y. H., Chiu, Y. J., Cheng, H-C., Liu, F. J., Lai, W-W., Chang, H. J. & Liao, P-C., 2015 May 28, In : Tumor Biology. 36, 5, p. 3957-3967 11 p.

Research output: Contribution to journalArticle

Tissue Inhibitor of Metalloproteinase-1
Cell Movement
Down-Regulation
Neoplasm Metastasis
Lymph
14 Citations (Scopus)

Epidermal growth factor-induced cyclooxygenase-2 enhances head and neck squamous cell carcinoma metastasis through fibronectin up-regulation

Hsu, J. Y., Chang, K. Y., Chen, S. H., Lee, C-T., Chang, S. T., Cheng, H-C., Chang, W. C. & Chen, B-K., 2015 Jan 1, In : Oncotarget. 6, 3, p. 1723-1739 17 p.

Research output: Contribution to journalArticle

Cyclooxygenase 2
Fibronectins
Epidermal Growth Factor
Up-Regulation
Neoplasm Metastasis
9 Citations (Scopus)

Growth-arrest-specific 7C protein inhibits tumor metastasis via the N-WASP/FAK/F-actin and hnRNP U/β-TrCP/β-catenin pathways in lung cancer

Tseng, R. C., Chang, J. W., Mao, J. S., Tsai, C. D., Wu, P. C., Lin, C. J., Lu, Y. L., Liao, S. Y., Cheng, H. C., Hsu, H. S. & Wang, Y. C., 2015 Jan 1, In : Oncotarget. 6, 42, p. 44207-44221 15 p.

Research output: Contribution to journalArticle

Heterogeneous-Nuclear Ribonucleoprotein U
Catenins
Actins
Lung Neoplasms
Neoplasm Metastasis
4 Citations (Scopus)

Optical detection of metastatic cancer cells using a scanned laser pico-projection system

Huang, C. L., Chiu, W. T., Lo, Y. L., Chuang, C. H., Chen, Y. B., Chang, S. J., Ke, T. T., Cheng, H. C. & Wu, H. L., 2015 Mar 1, In : Laser Physics Letters. 12, 3, 035602.

Research output: Contribution to journalArticle

Projection systems
projection
cancer
Cells
Lasers
2014
14 Citations (Scopus)

An increase in reactive oxygen species by deregulation of ARNT enhances chemotherapeutic drug-induced cancer cell death

Shieh, J. M., Shen, C. J., Chang, W. C., Cheng, H-C., Chan, Y. Y., Huang, W. C., Chang, W. C. & Chen, B-K., 2014 Jun 12, In : PLoS ONE. 9, 6, e99242.

Research output: Contribution to journalArticle

Aryl Hydrocarbon Receptor Nuclear Translocator
Deregulation
Cell death
hydrocarbons
cell death
14 Citations (Scopus)

Curcumin-induced aurora-a suppression not only causes mitotic defect and cell cycle arrest but also alters chemosensitivity to anticancer drugs

Ke, C. S., Liu, H-S., Yen, C. H., Huang, G. C., Cheng, H-C., Huang, C. Y. F. & Su, C. L., 2014 Jan 1, In : Journal of Nutritional Biochemistry. 25, 5, p. 526-539 14 p.

Research output: Contribution to journalArticle

Curcumin
Cell Cycle Checkpoints
Cells
Defects
Pharmaceutical Preparations
1 Citation (Scopus)

Impacts of protease inhibitors on clathrin and fibronectin in cancer metastasis

Wu, C. I., Chang, M. M., Su, C. L., Ling, P., Chang, W-T. & Cheng, H-C., 2014 Jan 1, In : Biomarkers and Genomic Medicine. 6, 1, p. 23-31 9 p.

Research output: Contribution to journalReview article

Clathrin
Protease Inhibitors
Fibronectins
Neoplasm Metastasis
Biomarkers
23 Citations (Scopus)

MiR-99a exerts anti-metastasis through inhibiting myotubularin-related protein 3 expression in oral cancer

Kuo, Y. Z., Tai, Y. H., Lo, H. I., Chen, Y-L., Cheng, H-C., Fang, W. Y., Lin, S-H., Yang, C. L., Tsai, S-T. & Wu, L-W., 2014 Jan 1, In : Oral Diseases. 20, 3

Research output: Contribution to journalArticle

Mouth Neoplasms
Neoplasm Metastasis
Cell Movement
Proteins
Cell Proliferation
19 Citations (Scopus)

Small GTPase Rab37 targets tissue inhibitor of metalloproteinase 1 for exocytosis and thus suppresses tumour metastasis

Tsai, C. H., Cheng, H-C., Wang, Y. S., Lin, P., Jen, J., Kuo, I. Y., Chang, Y. H., Liao, P-C., Chen, R. H., Yuan, W. C., Hsu, H. S., Yang, M. H., Hsu, M. T., Wu, C. Y. & Wang, Y-C., 2014 Sep 3, In : Nature communications. 5, 4804.

Research output: Contribution to journalArticle

Tissue Inhibitor of Metalloproteinase-1
Monomeric GTP-Binding Proteins
Exocytosis
metastasis
inhibitors
2013
17 Citations (Scopus)

CCAAT/Enhancer binding protein d in macrophages contributes to immunosuppression and inhibits phagocytosis in nasopharyngeal carcinoma

Hsiao, Y. W., Li, C. F., Chi, J. Y., Tseng, T-C., Chang, Y., Hsu, L-J., Lee, C. H., Chang, T. H., Wang, S. M., Wang, D. D. H., Cheng, H-C. & Wang, J-M., 2013 Jul 16, In : Science Signaling. 6, 284, ra59.

Research output: Contribution to journalArticle

CCAAT-Enhancer-Binding Proteins
Macrophages
Phagocytosis
Immunosuppression
Tumors
16 Citations (Scopus)

Glycosylation regulates the function and membrane localization of KCC4

Weng, T. Y., Chiu, W-T., Liu, H-S., Cheng, H-C., Shen, M-R., Mount, D. B. & Chou, C-Y., 2013 May 1, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1833, 5, p. 1133-1146 14 p.

Research output: Contribution to journalArticle

Glycosylation
Membranes
Polysaccharides
Mutation
Protein Folding
6 Citations (Scopus)

Inhibiting Interleukin-19 Activity Ameliorates Esophageal Squamous Cell Carcinoma Progression

Hsing, C. H., Kwok, F. A., Cheng, H-C., Li, C. F. & Chang, M-S., 2013 Oct 9, In : PloS one. 8, 10, e75254.

Research output: Contribution to journalArticle

Interleukins
squamous cell carcinoma
interleukins
Tumors
esophageal neoplasms
2012
16 Citations (Scopus)

Mitochondrial apoptosis and FAK signaling disruption by a novel histone deacetylase inhibitor, HTPB, in antitumor and antimetastatic mouse models

Shieh, J. M., Wei, T. T., Tang, Y. A., Huang, S. M., Wen, W. L., Chen, M. Y., Cheng, H-C., Salunke, S. B., Chen, C. S., Lin, P., Chen, C. T. & Wang, Y-C., 2012 Jan 18, In : PloS one. 7, 1, e30240.

Research output: Contribution to journalArticle

histone deacetylase
Histone Deacetylase Inhibitors
Tumors
apoptosis
animal models
11 Citations (Scopus)

Overexpression of PAFAH1B1 is associated with tumor metastasis and poor survival in non-small cell lung cancer

Lo, F. Y., Chen, H. T., Cheng, H-C., Hsu, H. S. & Wang, Y-C., 2012 Sep 1, In : Lung Cancer. 77, 3, p. 585-592 8 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Lung Neoplasms
Neoplasm Metastasis
Survival
Neoplasms
25 Citations (Scopus)

RUNX3-mediated transcriptional inhibition of Akt suppresses tumorigenesis of human gastric cancer cells

Lin, F. C., Liu, Y. P., Lai, C. H., Shan, Y. S., Cheng, H. C., Hsu, P. I., Lee, C. H., Lee, Y. C., Wang, H. Y., Wang, C. H., Cheng, J. Q., Hsiao, M. & Lu, P. J., 2012 Sep 27, In : Oncogene. 31, 39, p. 4302-4316 15 p.

Research output: Contribution to journalArticle

Stomach Neoplasms
Carcinogenesis
Cyclin D1
Catenins
Cell Line
29 Citations (Scopus)
alpha 1-Antitrypsin
Fibronectins
Cell Movement
Cells
Lung
28 Citations (Scopus)

Upregulated IL-19 in breast cancer promotes tumor progression and affects clinical outcome

Hsing, C. H., Cheng, H-C., Hsu, Y-H., Chan, C. H., Yeh, C. H., Li, C. F. & Chang, M-S., 2012 Feb 1, In : Clinical Cancer Research. 18, 3, p. 713-725 13 p.

Research output: Contribution to journalArticle

Interleukins
Breast Neoplasms
Neoplasms
Cell Movement
Carcinoma, Ductal, Breast
2011
22 Citations (Scopus)

An E3 ubiquitin ligase: C-Cbl: A new therapeutic target of lung cancer

Lo, F. Y., Tan, Y. H. C., Cheng, H-C., Salgia, R. & Wang, Y-C., 2011 Dec 1, In : Cancer. 117, 23, p. 5344-5350 7 p.

Research output: Contribution to journalArticle

Ubiquitin C
Ubiquitin-Protein Ligases
Lymphoma
Lung Neoplasms
Oncogene Protein v-cbl
68 Citations (Scopus)

A novel sialyltransferase inhibitor suppresses FAK/paxillin signaling and cancer angiogenesis and metastasis pathways

Chen, J. Y., Tang, Y. A., Huang, S. M., Juan, H. F., Wu, L-W., Sun, Y. C., Wang, S. C., Wu, K. W., Balraj, G., Chang, T. T., Li, W. S., Cheng, H-C. & Wang, Y-C., 2011 Jan 15, In : Cancer Research. 71, 2, p. 473-483 11 p.

Research output: Contribution to journalArticle

Sialyltransferases
Paxillin
Neoplasm Metastasis
Neoplasms
N-Acetylneuraminic Acid
35 Citations (Scopus)

Curcumin-induced mitotic spindle defect and cell cycle arrest in human bladder cancer cells occurs partly through inhibition of aurora A

Liu, H-S., Ke, C. S., Cheng, H-C., Huang, C. Y. F. & Su, C. L., 2011 Oct 1, In : Molecular Pharmacology. 80, 4, p. 638-646 9 p.

Research output: Contribution to journalArticle

Spindle Apparatus
Curcumin
Cell Cycle Checkpoints
Urinary Bladder Neoplasms
Neoplasms
9 Citations (Scopus)

Identifying LRRC16B as an oncofetal gene with transforming enhancing capability using a combined bioinformatics and experimental approach

Hsu, C. C., Chiang, C-W., Cheng, H-C., Chang, W-T., Chou, C-Y., Tsai, H-W., Lee, C-T., Wu, Z. H., Lee, T. Y., Chao, A., Chow, N-H. & Ho, C-L., 2011 Feb 10, In : Oncogene. 30, 6, p. 654-667 14 p.

Research output: Contribution to journalArticle

Computational Biology
Oncogenes
Genes
Cyclin B1
Inosine Monophosphate
18 Citations (Scopus)

TBK1-associated Protein in Endolysosomes (TAPE) is an innate immune regulator modulating the TLR3 and TLR4 signaling pathways

Chang, C. H., Lai, L. C., Cheng, H-C., Chen, K. R., Syue, Y. Z., Lu, H. C., Lin, W. Y., Chen, S., Huang, H-S., Shiau, A-L., Lei, H. Y., Qin, J. & Ling, P., 2011 Mar 4, In : Journal of Biological Chemistry. 286, 9, p. 7043-7051 9 p.

Research output: Contribution to journalArticle

Proteins
MAP Kinase Signaling System
Immune system
Pathogens
Immune System
2009
6 Citations (Scopus)

Epitope analysis of the rat dipeptidyl peptidase IV monoclonal antibody 6A3 that blocks pericellular fibronectin-mediated cancer cell adhesion

Hung, T. T., Wu, J. Y., Liu, J. F. & Cheng, H-C., 2009 Nov 1, In : FEBS Journal. 276, 22, p. 6548-6559 12 p.

Research output: Contribution to journalArticle

Dipeptidyl Peptidase 4
Cell adhesion
Fibronectins
Cell Adhesion
Rats
2008
22 Citations (Scopus)

Protein kinase Cε mediates polymeric fibronectin assembly on the surface of blood-borne rat breast cancer cells to promote pulmonary metastasis

Huang, L., Cheng, H-C., Isom, R., Chen, C. S., Levine, R. A. & Pauli, B. U., 2008 Mar 21, In : Journal of Biological Chemistry. 283, 12, p. 7616-7627 12 p.

Research output: Contribution to journalArticle

Fibronectins
Protein Kinase C
Rats
Blood
Cells
2006
27 Citations (Scopus)

The putative chloride channel hCLCA2 has a single C-terminal transmembrane segment

Elble, R. C., Walia, V., Cheng, H-C., Connon, C. J., Mundhenk, L., Gruber, A. D. & Pauli, B. U., 2006 Oct 6, In : Journal of Biological Chemistry. 281, 40, p. 29448-29454 7 p.

Research output: Contribution to journalArticle

Chloride Channels
Cell membranes
Amino Acids
Endoplasmic Reticulum
Cell Membrane
2003
82 Citations (Scopus)

A Novel Consensus Motif in Fibronectin Mediates Dipeptidyl Peptidase IV Adhesion and Metastasis

Cheng, H-C., Abdel-Ghany, M. & Pauli, B. U., 2003 Jul 4, In : Journal of Biological Chemistry. 278, 27, p. 24600-24607 8 p.

Research output: Contribution to journalArticle

Dipeptidyl Peptidase 4
Fibronectins
Adhesion
Neoplasm Metastasis
Binding Sites
48 Citations (Scopus)

The interacting binding domains of the beta(4) integrin and calcium-activated chloride channels (CLCAs) in metastasis.

Abdel-Ghany, M., Cheng, H-C., Elble, R. C., Lin, H., DiBiasio, J. & Pauli, B. U., 2003 Jan 1, In : The Journal of biological chemistry. 278, 49, p. 49406-49416 11 p.

Research output: Contribution to journalArticle

Integrin beta4
Chloride Channels
Neoplasm Metastasis
CD29 Antigens
Fusion reactions
2002
93 Citations (Scopus)

Focal adhesion kinase activated by β4 integrin ligation to mCLCA1 mediates early metastatic growth

Abdel-Ghany, M., Cheng, H-C., Elble, R. C. & Pauli, B. U., 2002 Sep 13, In : Journal of Biological Chemistry. 277, 37, p. 34391-34400 10 p.

Research output: Contribution to journalArticle

Focal Adhesion Protein-Tyrosine Kinases
Integrins
Ligation
Extracellular Signal-Regulated MAP Kinases
Growth
2001
99 Citations (Scopus)

The Breast Cancer β4 Integrin and Endothelial Human CLCA2 Mediate Lung Metastasis

Abdel-Ghany, M., Cheng, H-C., Elble, R. C. & Pauli, B. U., 2001 Jul 6, In : Journal of Biological Chemistry. 276, 27, p. 25438-25446 9 p.

Research output: Contribution to journalArticle

Integrins
Breast Neoplasms
Adhesion
Neoplasm Metastasis
Lung
2000
81 Citations (Scopus)

Molecular characteristics and functional diversity of CLCA family members

Pauli, B. U., Abdel-Ghany, M., Cheng, H-C., Gruber, A. D., Archibald, H. A. & Elble, R. C., 2000 Nov 20, In : Clinical and Experimental Pharmacology and Physiology. 27, 11, p. 901-905 5 p.

Research output: Contribution to journalArticle

Chloride Channels
Breast Neoplasms
Lung
Vascular Endothelium
Nude Mice
1999
24 Citations (Scopus)

Is the Fischer 344/CRJ rat a protein-knock-out model for dipeptidyl peptidase IV-mediated lung metastasis of breast cancer?

Cheng, H-C., Abdel-Ghany, M., Zhang, S. & Pauli, B. U., 1999 Dec 1, In : Clinical and Experimental Metastasis. 17, 7, p. 609-615 7 p.

Research output: Contribution to journalArticle

Dipeptidyl Peptidase 4
Breast Neoplasms
Neoplasm Metastasis
Lung
Proteins
1998
132 Citations (Scopus)

Lung endothelial dipeptidyl peptidase IV promotes adhesion and metastasis of rat breast cancer cells via tumor cell surface-associated fibronectin

Cheng, H-C., Abdel-Ghany, M., Elble, R. C. & Pauli, B. U., 1998 Sep 11, In : Journal of Biological Chemistry. 273, 37, p. 24207-24215 9 p.

Research output: Contribution to journalArticle

Dipeptidyl Peptidase 4
Fibronectins
Rats
Tumors
Adhesion

Lung endothelial DPP IV promotes adhesion and metastasis of rat breast cancer cells via tumor cell surface-associated fibronectin

Cheng, H-C., Abdel-Ghany, M., Elble, R. C. & Pauli, B. U., 1998 Mar 20, In : FASEB Journal. 12, 5

Research output: Contribution to journalArticle

Dipeptidyl Peptidase 4
Fibronectins
Rats
Tumors
Adhesion
27 Citations (Scopus)

Truncated dipeptidyl peptidase IV is a potent anti-adhesion and anti-metastasis peptide for rat breast cancer cells

Abdel-Ghany, M., Cheng, H-C., Levine, R. A. & Pauli, B. U., 1998 Jan 1, In : Invasion and Metastasis. 18, 1, p. 35-43 9 p.

Research output: Contribution to journalArticle

Dipeptidyl Peptidase 4
Fibronectins
Breast Neoplasms
Neoplasm Metastasis
Peptides
1997
84 Citations (Scopus)

Cloning and characterization of lung-endothelial cell adhesion molecule- 1 suggest it is an endothelial chloride channel

Elble, R. C., Widom, J., Gruber, A. D., Abdel-Ghany, M., Levine, R., Goodwin, A., Cheng, H-C. & Pauli, B. U., 1997 Oct 31, In : Journal of Biological Chemistry. 272, 44, p. 27853-27861 9 p.

Research output: Contribution to journalArticle

Chloride Channels
Cloning
Endothelial cells
Cell Adhesion Molecules
Organism Cloning
1996
2 Citations (Scopus)

Purification and characterization of endogenous digoxin-like immunoreactive factors in chicken blood

Wei, J. S., Cheng, H-C., Tsai, K. J., Liu, D. H., Lee, H. H., Chiu, D. T. Y. & Liu, T. Z., 1996 Oct 4, In : Life Sciences. 59, 19, p. 1617-1629 13 p.

Research output: Contribution to journalArticle

Purification
Chickens
Digoxin
Blood
Plasmas

PHARMACEUTICAL COMPOSITION FOR DIAGNOSING CARCINOMA METASTASIS

Cheng, H-C., 1800, Patent No. I532995

Research output: Patent