• 1267 Citations
  • 20 h-Index
19962018

Research output per year

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Research Output

  • 1267 Citations
  • 20 h-Index
  • 44 Article
  • 4 Patent
  • 2 Review article
  • 1 Chapter
2018

Apoptotic and nonapoptotic activities of pterostilbene against cancer

Chen, R. J., Kuo, H. C., Cheng, L. H., Lee, Y. H., Chang, W. T., Wang, B. J., Wang, Y. J. & Cheng, H. C., 2018 Jan 18, In : International journal of molecular sciences. 19, 1, 287.

Research output: Contribution to journalReview article

8 Citations (Scopus)

Decreased succinate dehydrogenase B in human hepatocellular carcinoma accelerates tumor malignancy by inducing the Warburg effect

Tseng, P. L., Wu, W. H., Hu, T. H., Chen, C. W., Cheng, H. C., Li, C. F., Tsai, W. H., Tsai, H. J., Hsieh, M. C., Chuang, J. H. & Chang, W. T., 2018 Dec 1, In : Scientific reports. 8, 1, 3081.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Glycine N-methyltransferase inhibits aristolochic acid nephropathy by increasing CYP3A44 and decreasing NQO1 expression in female mouse hepatocytes

Chang, M. M., Lin, C. N., Fang, C. C., Chen, M., Liang, P. I., Li, W. M., Yeh, B. W., Cheng, H. C., Huang, B. M., Wu, W. J. & Chen, Y. M. A., 2018 Dec 1, In : Scientific reports. 8, 1, 6960.

Research output: Contribution to journalArticle

6 Citations (Scopus)

The decrease of glycolytic enzyme hexokinase 1 accelerates tumor malignancy via deregulating energy metabolism but sensitizes cancer cells to 2-deoxyglucose inhibition

Tseng, P. L., Chen, C. W., Hu, K. H., Cheng, H. C., Lin, Y. H., Tsai, W. H., Cheng, T. J., Wu, W. H., Yeh, C. W., Lin, C. C., Tsai, H. J., Chang, H. C., Chuang, J. H., Shan, Y. S. & Chang, W. T., 2018 Apr 10, In : Oncotarget. 9, 27, p. 18949-18969 21 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

The establishment of a lung colonization assay for circulating tumor cell visualization in lung tissues

Lin, T. C., Liao, Y. C., Chang, W. T., Yang, C. H., Cheng, L. H., Cheng, M. & Cheng, H. C., 2018 Jun 18, In : Journal of Visualized Experiments. 2018, 136, e56761.

Research output: Contribution to journalArticle

VAMP8, a vesicle-SNARE required for RAB37-mediated exocytosis, possesses a tumor metastasis suppressor function

Wang, Y., Tzeng, H., Tsai, C., Cheng, H., Lai, W., Liu, H. & Wang, Y., 2018 Nov 1, In : Cancer Letters. 437, p. 79-88

Research output: Contribution to journalArticle

2 Citations (Scopus)
2017

Dysregulation of Rab37-mediated cross-talk between cancer cells and endothelial cells via thrombospondin-1 promotes tumor neovasculature and metastasis

Tzeng, H. T., Tsai, C. H., Yen, Y. T., Cheng, H. C., Chen, Y. C., Pu, S. W., Wang, Y. S., Shan, Y. S., Tseng, Y. L., Su, W. C., Lai, W. W., Wu, L. W. & Wang, Y. C., 2017 May 1, In : Clinical Cancer Research. 23, 9, p. 2335-2345 11 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Increased risk of brain cancer incidence in stroke patients: A clinical case series, population-based and longitudinal follow-up study

Chen, C. W., Cheng, T. J., Ho, C. H., Wang, J. J., Weng, S. F., Hou, Y. C., Cheng, H. C., Chio, C. C., Shan, Y. S. & Chang, W. T., 2017 Jan 1, In : Oncotarget. 8, 65, p. 108989-108999 11 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)
12 Citations (Scopus)

Ubiquitination of tumor suppressor PML regulates prometastatic and immunosuppressive tumor microenvironment

Wang, Y. T., Chen, J., Chang, C. W., Jen, J., Huang, T. Y., Chen, C. M., Shen, R., Liang, S. Y., Cheng, I. C., Yang, S. C., Lai, W. W., Cheng, K. H., Hsieh, T. S., Lai, M. Z., Cheng, H. C., Wang, Y. C. & Chen, R. H., 2017 Aug 1, In : Journal of Clinical Investigation. 127, 8, p. 2982-2997 16 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)
2015

Down-regulation of TIMP-1 inhibits cell migration, invasion, and metastatic colonization in lung adenocarcinoma

Chang, Y. H., Chiu, Y. J., Cheng, H. C., Liu, F. J., Lai, W. W., Chang, H. J. & Liao, P. C., 2015 May 28, In : Tumor Biology. 36, 5, p. 3957-3967 11 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Epidermal growth factor-induced cyclooxygenase-2 enhances head and neck squamous cell carcinoma metastasis through fibronectin up-regulation

Hsu, J. Y., Chang, K. Y., Chen, S. H., Lee, C. T., Chang, S. T., Cheng, H. C., Chang, W. C. & Chen, B. K., 2015 Jan 1, In : Oncotarget. 6, 3, p. 1723-1739 17 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Growth-arrest-specific 7C protein inhibits tumor metastasis via the N-WASP/FAK/F-actin and hnRNP U/β-TrCP/β-catenin pathways in lung cancer

Tseng, R. C., Chang, J. W., Mao, J. S., Tsai, C. D., Wu, P. C., Lin, C. J., Lu, Y. L., Liao, S. Y., Cheng, H. C., Hsu, H. S. & Wang, Y. C., 2015 Jan 1, In : Oncotarget. 6, 42, p. 44207-44221 15 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Optical detection of metastatic cancer cells using a scanned laser pico-projection system

Huang, C. L., Chiu, W. T., Lo, Y. L., Chuang, C. H., Chen, Y. B., Chang, S. J., Ke, T. T., Cheng, H. C. & Wu, H. L., 2015 Mar 1, In : Laser Physics Letters. 12, 3, 035602.

Research output: Contribution to journalArticle

4 Citations (Scopus)
2014

An increase in reactive oxygen species by deregulation of ARNT enhances chemotherapeutic drug-induced cancer cell death

Shieh, J. M., Shen, C. J., Chang, W. C., Cheng, H. C., Chan, Y. Y., Huang, W. C., Chang, W. C. & Chen, B. K., 2014 Jun 12, In : PloS one. 9, 6, e99242.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Curcumin-induced aurora-a suppression not only causes mitotic defect and cell cycle arrest but also alters chemosensitivity to anticancer drugs

Ke, C. S., Liu, H-S., Yen, C. H., Huang, G. C., Cheng, H-C., Huang, C. Y. F. & Su, C. L., 2014 Jan 1, In : Journal of Nutritional Biochemistry. 25, 5, p. 526-539 14 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Impacts of protease inhibitors on clathrin and fibronectin in cancer metastasis

Wu, C. I., Chang, M. M., Su, C. L., Ling, P., Chang, W. T. & Cheng, H. C., 2014 Mar, In : Biomarkers and Genomic Medicine. 6, 1, p. 23-31 9 p.

Research output: Contribution to journalReview article

1 Citation (Scopus)

MiR-99a exerts anti-metastasis through inhibiting myotubularin-related protein 3 expression in oral cancer

Kuo, Y. Z., Tai, Y. H., Lo, H. I., Chen, Y. L., Cheng, H. C., Fang, W. Y., Lin, S. H., Yang, C. L., Tsai, S. T. & Wu, L. W., 2014 Apr, In : Oral Diseases. 20, 3, p. e65-e75

Research output: Contribution to journalArticle

31 Citations (Scopus)

Small GTPase Rab37 targets tissue inhibitor of metalloproteinase 1 for exocytosis and thus suppresses tumour metastasis

Tsai, C. H., Cheng, H. C., Wang, Y. S., Lin, P., Jen, J., Kuo, I. Y., Chang, Y. H., Liao, P. C., Chen, R. H., Yuan, W. C., Hsu, H. S., Yang, M. H., Hsu, M. T., Wu, C. Y. & Wang, Y. C., 2014 Sep 3, In : Nature communications. 5, 4804.

Research output: Contribution to journalArticle

22 Citations (Scopus)
2013

CCAAT/Enhancer binding protein d in macrophages contributes to immunosuppression and inhibits phagocytosis in nasopharyngeal carcinoma

Hsiao, Y. W., Li, C. F., Chi, J. Y., Tseng, J. T., Chang, Y., Hsu, L. J., Lee, C. H., Chang, T. H., Wang, S. M., Wang, D. D. H., Cheng, H. C. & Wang, J. M., 2013 Jul 16, In : Science Signaling. 6, 284, ra59.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Glycosylation regulates the function and membrane localization of KCC4

Weng, T. Y., Chiu, W. T., Liu, H. S., Cheng, H. C., Shen, M. R., Mount, D. B. & Chou, C. Y., 2013 May 1, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1833, 5, p. 1133-1146 14 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Inhibiting Interleukin-19 Activity Ameliorates Esophageal Squamous Cell Carcinoma Progression

Hsing, C. H., Kwok, F. A., Cheng, H. C., Li, C. F. & Chang, M. S., 2013 Oct 9, In : PloS one. 8, 10, e75254.

Research output: Contribution to journalArticle

6 Citations (Scopus)
2012

Mitochondrial apoptosis and FAK signaling disruption by a novel histone deacetylase inhibitor, HTPB, in antitumor and antimetastatic mouse models

Shieh, J. M., Wei, T. T., Tang, Y. A., Huang, S. M., Wen, W. L., Chen, M. Y., Cheng, H. C., Salunke, S. B., Chen, C. S., Lin, P., Chen, C. T. & Wang, Y. C., 2012 Jan 18, In : PloS one. 7, 1, e30240.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Overexpression of PAFAH1B1 is associated with tumor metastasis and poor survival in non-small cell lung cancer

Lo, F. Y., Chen, H. T., Cheng, H. C., Hsu, H. S. & Wang, Y. C., 2012 Sep 1, In : Lung Cancer. 77, 3, p. 585-592 8 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

RUNX3-mediated transcriptional inhibition of Akt suppresses tumorigenesis of human gastric cancer cells

Lin, F. C., Liu, Y. P., Lai, C. H., Shan, Y. S., Cheng, H. C., Hsu, P. I., Lee, C. H., Lee, Y. C., Wang, H. Y., Wang, C. H., Cheng, J. Q., Hsiao, M. & Lu, P. J., 2012 Sep 27, In : Oncogene. 31, 39, p. 4302-4316 15 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)
34 Citations (Scopus)

Upregulated IL-19 in breast cancer promotes tumor progression and affects clinical outcome

Hsing, C. H., Cheng, H. C., Hsu, Y. H., Chan, C. H., Yeh, C. H., Li, C. F. & Chang, M. S., 2012 Feb 1, In : Clinical Cancer Research. 18, 3, p. 713-725 13 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)
2011

An E3 ubiquitin ligase: C-Cbl: A new therapeutic target of lung cancer

Lo, F. Y., Tan, Y. H. C., Cheng, H. C., Salgia, R. & Wang, Y. C., 2011 Dec 1, In : Cancer. 117, 23, p. 5344-5350 7 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

A novel sialyltransferase inhibitor suppresses FAK/paxillin signaling and cancer angiogenesis and metastasis pathways

Chen, J. Y., Tang, Y. A., Huang, S. M., Juan, H. F., Wu, L. W., Sun, Y. C., Wang, S. C., Wu, K. W., Balraj, G., Chang, T. T., Li, W. S., Cheng, H. C. & Wang, Y. C., 2011 Jan 15, In : Cancer Research. 71, 2, p. 473-483 11 p.

Research output: Contribution to journalArticle

72 Citations (Scopus)

Curcumin-induced mitotic spindle defect and cell cycle arrest in human bladder cancer cells occurs partly through inhibition of aurora A

Liu, H. S., Ke, C. S., Cheng, H. C., Huang, C. Y. F. & Su, C. L., 2011 Oct 1, In : Molecular Pharmacology. 80, 4, p. 638-646 9 p.

Research output: Contribution to journalArticle

41 Citations (Scopus)
10 Citations (Scopus)

TBK1-associated Protein in Endolysosomes (TAPE) is an innate immune regulator modulating the TLR3 and TLR4 signaling pathways

Chang, C. H., Lai, L. C., Cheng, H. C., Chen, K. R., Syue, Y. Z., Lu, H. C., Lin, W. Y., Chen, S. H., Huang, H. S., Shiau, A. L., Lei, H. Y., Qin, J. & Ling, P., 2011 Mar 4, In : Journal of Biological Chemistry. 286, 9, p. 7043-7051 9 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)
2009

Epitope analysis of the rat dipeptidyl peptidase IV monoclonal antibody 6A3 that blocks pericellular fibronectin-mediated cancer cell adhesion

Hung, T. T., Wu, J. Y., Liu, J. F. & Cheng, H-C., 2009 Nov 1, In : FEBS Journal. 276, 22, p. 6548-6559 12 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)
2008

Protein kinase Cε mediates polymeric fibronectin assembly on the surface of blood-borne rat breast cancer cells to promote pulmonary metastasis

Huang, L., Cheng, H-C., Isom, R., Chen, C. S., Levine, R. A. & Pauli, B. U., 2008 Mar 21, In : Journal of Biological Chemistry. 283, 12, p. 7616-7627 12 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)
2006

The putative chloride channel hCLCA2 has a single C-terminal transmembrane segment

Elble, R. C., Walia, V., Cheng, H-C., Connon, C. J., Mundhenk, L., Gruber, A. D. & Pauli, B. U., 2006 Oct 6, In : Journal of Biological Chemistry. 281, 40, p. 29448-29454 7 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)
2003

A Novel Consensus Motif in Fibronectin Mediates Dipeptidyl Peptidase IV Adhesion and Metastasis

Cheng, H. C., Abdel-Ghany, M. & Pauli, B. U., 2003 Jul 4, In : Journal of Biological Chemistry. 278, 27, p. 24600-24607 8 p.

Research output: Contribution to journalArticle

86 Citations (Scopus)

The interacting binding domains of the beta(4) integrin and calcium-activated chloride channels (CLCAs) in metastasis.

Abdel-Ghany, M., Cheng, H. C., Elble, R. C., Lin, H., DiBiasio, J. & Pauli, B. U., 2003 Dec 5, In : The Journal of biological chemistry. 278, 49, p. 49406-49416 11 p.

Research output: Contribution to journalArticle

49 Citations (Scopus)
2002

CLCA adhesion in site-specific cancer metastasis

Pauli, B. U., Cheng, H. C. & Abdel-Ghany, M., 2002 Dec 1, Calcium-Activated Chloride Channels. p. 415-430 16 p. (Current Topics in Membranes; vol. 53).

Research output: Chapter in Book/Report/Conference proceedingChapter

Focal adhesion kinase activated by β4 integrin ligation to mCLCA1 mediates early metastatic growth

Abdel-Ghany, M., Cheng, H. C., Elble, R. C. & Pauli, B. U., 2002 Sep 13, In : Journal of Biological Chemistry. 277, 37, p. 34391-34400 10 p.

Research output: Contribution to journalArticle

94 Citations (Scopus)
2001

The Breast Cancer β4 Integrin and Endothelial Human CLCA2 Mediate Lung Metastasis

Abdel-Ghany, M., Cheng, H. C., Elble, R. C. & Pauli, B. U., 2001 Jul 6, In : Journal of Biological Chemistry. 276, 27, p. 25438-25446 9 p.

Research output: Contribution to journalArticle

100 Citations (Scopus)
2000

Molecular characteristics and functional diversity of CLCA family members

Pauli, B. U., Abdel-Ghany, M., Cheng, H. C., Gruber, A. D., Archibald, H. A. & Elble, R. C., 2000 Nov 20, In : Clinical and Experimental Pharmacology and Physiology. 27, 11, p. 901-905 5 p.

Research output: Contribution to journalArticle

82 Citations (Scopus)
1999

Is the Fischer 344/CRJ rat a protein-knock-out model for dipeptidyl peptidase IV-mediated lung metastasis of breast cancer?

Cheng, H. C., Abdel-Ghany, M., Zhang, S. & Pauli, B. U., 1999 Dec 1, In : Clinical and Experimental Metastasis. 17, 7, p. 609-615 7 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)
1998

Lung endothelial dipeptidyl peptidase IV promotes adhesion and metastasis of rat breast cancer cells via tumor cell surface-associated fibronectin

Cheng, H. C., Abdel-Ghany, M., Elble, R. C. & Pauli, B. U., 1998 Sep 11, In : Journal of Biological Chemistry. 273, 37, p. 24207-24215 9 p.

Research output: Contribution to journalArticle

132 Citations (Scopus)

Lung endothelial DPP IV promotes adhesion and metastasis of rat breast cancer cells via tumor cell surface-associated fibronectin

Cheng, H-C., Abdel-Ghany, M., Elble, R. C. & Pauli, B. U., 1998 Mar 20, In : FASEB Journal. 12, 5

Research output: Contribution to journalArticle

Truncated dipeptidyl peptidase IV is a potent anti-adhesion and anti-metastasis peptide for rat breast cancer cells

Abdel-Ghany, M., Cheng, H-C., Levine, R. A. & Pauli, B. U., 1998 Jan 1, In : Invasion and Metastasis. 18, 1, p. 35-43 9 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)
1997

Cloning and characterization of lung-endothelial cell adhesion molecule- 1 suggest it is an endothelial chloride channel

Elble, R. C., Widom, J., Gruber, A. D., Abdel-Ghany, M., Levine, R., Goodwin, A., Cheng, H-C. & Pauli, B. U., 1997 Oct 31, In : Journal of Biological Chemistry. 272, 44, p. 27853-27861 9 p.

Research output: Contribution to journalArticle

84 Citations (Scopus)
1996

Purification and characterization of endogenous digoxin-like immunoreactive factors in chicken blood

Wei, J. S., Cheng, H. C., Tsai, K. J., Liu, D. H., Lee, H. H., Chiu, D. T. Y. & Liu, T. Z., 1996 Oct 4, In : Life Sciences. 59, 19, p. 1617-1629 13 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

PHARMACEUTICAL COMPOSITION FOR DIAGNOSING CARCINOMA METASTASIS

Cheng, H-C., 1800, Patent No. I532995

Research output: Patent