• 1032 Citations
  • 16 h-Index
20052019
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Research Output 2005 2019

  • 1032 Citations
  • 16 h-Index
  • 68 Article
  • 2 Conference contribution
  • 2 Letter
  • 2 Review article
2019

Automatic HCC Detection Using Convolutional Network with Multi-Magnification Input Images

Huang, W. C., Chung, P-C., Tsai, H-W., Chow, N-H., Juang, Y. Z., Tsai, H. H., Lin, S. H. & Wang, C. H., 2019 Mar 1, Proceedings 2019 IEEE International Conference on Artificial Intelligence Circuits and Systems, AICAS 2019. Institute of Electrical and Electronics Engineers Inc., p. 194-198 5 p. 8771535. (Proceedings 2019 IEEE International Conference on Artificial Intelligence Circuits and Systems, AICAS 2019).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Liver
Tumors
Tissue
Cell death
Network architecture

Fully galactosyl-fucosyl-bisected IgG 1 reduces anti-HBV efficacy and liver histological improvement

Ho, C. H., Chen, S-H., Tsai, H-W., Wu, I-C. & Chang, T-T., 2019 Mar 1, In : Antiviral Research. 163, p. 1-10 10 p.

Research output: Contribution to journalArticle

Hepatitis B virus
Immunoglobulin G
Liver
Hepatitis B e Antigens
Acetylglucosamine

Plasma proteome plus site-specific N-glycoprofiling for hepatobiliary carcinomas

Chang, T-T., Cheng, J. H., Tsai, H-W., Young, K-C., Hsieh, S-Y. & Ho, C. H., 2019 Jul 1, In : Journal of Pathology: Clinical Research. 5, 3, p. 199-212 14 p.

Research output: Contribution to journalArticle

Open Access
Proteome
Complement C3
Carcinoma
Hepatocellular Carcinoma
Cholangiocarcinoma
2018
3 Citations (Scopus)

Exendin-4 improves cardiovascular function and survival in flow-induced pulmonary hypertension

Roan, J-N., Hsu, C-H., Fang, S-Y., Tsai, H-W., Luo, C-Y., Huang, C. C. & Lam, C. F., 2018 Apr 1, In : Journal of Thoracic and Cardiovascular Surgery. 155, 4, p. 1661-1669.e4

Research output: Contribution to journalArticle

Pulmonary Hypertension
Pulmonary Artery
Glucagon-Like Peptides
Heart Ventricles
Lung
2 Citations (Scopus)
Cholangiocarcinoma
Immunoglobulin G
Macrophages
Neoplasm Metastasis
Recurrence

Ground glass hepatocytes provide targets for therapy or prevention of hepatitis B virus-related hepatocellular carcinoma

Chang, H., Tsai, H., Teng, C., Hui-ching Wang, L., Huang, W. & Su, I., 2018 Mar 1, In : AIMS Medical Science. 5, 2, p. 90-101

Research output: Contribution to journalArticle

Hepatitis B virus surface gene pre-S2 mutant as a high-risk serum marker for hepatoma recurrence after curative hepatic resection

Yen, C., Ai, Y., Tsai, H., Chan, S., Yen, C., Cheng, K., Lee, Y., Kao, C., Wang, Y., Chen, Y., Lin, C., Liu, T., Tsai, H., Wang, J., Su, I. & Huang, W., 2018 Sep 1, In : Hepatology. 68, 3, p. 815-826

Research output: Contribution to journalArticle

5 Citations (Scopus)

Hepatitis B virus surface gene pre-S2 mutant as a high-risk serum marker for hepatoma recurrence after curative hepatic resection

Yen, C. J., Ai, Y. L., Tsai, H. W., Chan, S. H., Yen, C. S., Cheng, K. H., Lee, Y. P., Kao, C. W., Wang, Y. C., Chen, Y. L., Lin, C. H., Liu, T., Tsai, H. P., Wang, J. R., Su, I. J. & Huang, W., 2018 Sep, In : Hepatology. 68, 3, p. 815-826 12 p.

Research output: Contribution to journalArticle

Hepatitis B virus
Hepatocellular Carcinoma
Biomarkers
Recurrence
Surface Antigens
3 Citations (Scopus)

Intrahepatic hepatitis B virus large surface antigen induces hepatocyte hyperploidy via failure of cytokinesis

Li, T. N., Wu, Y. J., Tsai, H-W., Sun, C. P., Wu, Y. H., Wu, H. L., Pei, Y. N., Lu, K. Y., Yen, T. T. C., Chang, C. W., Chan, H. L., Tao, M. H., Liou, J. Y., Chang, M. D. T., Su, I. J. & Wang, L. H. C., 2018 Aug 1, In : Journal of Pathology. 245, 4, p. 502-513 12 p.

Research output: Contribution to journalArticle

Cytokinesis
Surface Antigens
Hepatitis B virus
Hepatocytes
DNA Damage
1 Citation (Scopus)

Liver regeneration accelerates hepatitis B virus-related tumorigenesis of hepatocellular carcinoma

Teng, C. F., Chang, H. Y., Tsai, H-W., Hsieh, W. C., Kuo, Y. H., Su, I. J. & Lin, Y-J., 2018 Jun 1, In : Molecular Oncology. 12, 7, p. 1175-1187 13 p.

Research output: Contribution to journalArticle

Liver Regeneration
Hepatectomy
Hepatitis B virus
Hepatocellular Carcinoma
Carcinogenesis
1 Citation (Scopus)

Progesterone receptor membrane component 1 as a potential prognostic biomarker for hepatocellular carcinoma

Tsai, H-W., Ho, C-L., Cheng, S. W., Lin, Y-J., Chen, C. C., Cheng, P-N., Yen, C-J., Chang, T-T., Chiang, P-M., Chan, S-H., Ho, C. H., Chen, S-H., Wang, Y. W., Chow, N-H. & Lin, J. C., 2018 Mar 14, In : World journal of gastroenterology. 24, 10, p. 1152-1166 15 p.

Research output: Contribution to journalArticle

Progesterone Receptors
Hepatocellular Carcinoma
Biomarkers
Membranes
Atlases
Systemic Lupus Erythematosus
Hemorrhage
Extracorporeal Membrane Oxygenation
Plasmapheresis
Methylprednisolone
2017
4 Citations (Scopus)
Term Birth
Neuroendocrine Carcinoma
Small Cell Carcinoma
Cervix Uteri
Fertility
1 Citation (Scopus)

Favorable Response to Long-term Nucleos(t)ide Analogue Therapy in HBeAg-positive Patients with High Serum Fucosyl-Agalactosyl IgG

Ho, C. H., Tsai, H-W., Lee, C. Y., Huang, L. J., Chien, R. N., Wu, I-C., Chiu, Y-C., Liu, W. C., Cheng, P-N., Chang, T-T. & Chen, S-H., 2017 Dec 1, In : Scientific reports. 7, 1, 1957.

Research output: Contribution to journalArticle

Hepatitis B e Antigens
Immunoglobulin G
Hepatitis B virus
Serum
Therapeutics
5 Citations (Scopus)
Mucinous Adenocarcinoma
Adenocarcinoma
CpG Islands
Survival
Phenotype
2016
2 Citations (Scopus)

Prediction of early hepatocellular carcinoma recurrence using germinal center kinase-like kinase

Ho, C. H., Chuang, H. C., Wu, I-C., Tsai, H-W., Lin, Y-J., Sun, H. Y., Young, K-C., Chiu, Y-C., Cheng, P-N., Liu, W. C., Tan, T. H. & Chang, T-T., 2016 Jan 1, In : Oncotarget. 7, 31, p. 49765-49776 12 p.

Research output: Contribution to journalArticle

Hepatocellular Carcinoma
Phosphotransferases
Recurrence
NF-kappa B
Liver
7 Citations (Scopus)
Chronic Hepatitis B
Antiviral Agents
Glass
Hepatocytes
Hepatocellular Carcinoma
6 Citations (Scopus)
Protein Phosphatase 2
Phosphorylation
Neoplasms
Okadaic Acid
Holoenzymes
14 Citations (Scopus)

Toll-like receptor 4 is essential in the development of abdominal aortic aneurysm

Lai, C-H., Wang, K. C., Lee, F. T., Tsai, H-W., Ma, C. Y., Cheng, T. L., Chang, B. I., Yang, Y. J., Shi, G. Y. & Wu, H-L., 2016 Jan 7, In : PloS one. 11, 1, e0146565.

Research output: Contribution to journalArticle

aneurysm
Toll-Like Receptor 4
Abdominal Aortic Aneurysm
Vascular Smooth Muscle
Smooth Muscle Myocytes
2015
11 Citations (Scopus)

Aberrant serum immunoglobulin g glycosylation in chronic hepatitis b is associated with histological liver damage and reversible by antiviral therapy

Ho, C. H., Chien, R. N., Cheng, P-N., Liu, J. H., Liu, C. K., Su, C. S., Wu, I. C., Li, I. C., Tsai, H-W., Wu, S. L., Liu, W. C., Chen, S-H. & Chang, T-T., 2015 Jan 1, In : Journal of Infectious Diseases. 211, 1, p. 115-124 10 p.

Research output: Contribution to journalArticle

Chronic Hepatitis
Glycosylation
Antiviral Agents
Immunoglobulins
Chronic Hepatitis B
13 Citations (Scopus)

Activation of ATP citrate lyase by mTOR signal induces disturbed lipid metabolism in hepatitis B virus Pre-S2 mutant tumorigenesis

Teng, C. F., Wu, H. C., Hsieh, W. C., Tsai, H-W. & Su, I. J., 2015 Jan 1, In : Journal of Virology. 89, 1, p. 605-614 10 p.

Research output: Contribution to journalArticle

ATP Citrate (pro-S)-Lyase
ATP citrate synthase
Hepatitis B virus
Sirolimus
Lipid Metabolism
4 Citations (Scopus)

Antiangiogenesis as the novel mechanism for justicidin A in the anticancer effect on human bladder cancer

Wang, Y. W., Chuang, J. J., Chang, T. Y., Won, S. J., Tsai, H-W., Lee, C-T., Cheng, H-L., Tzai, T. S., Liu, H-S. & Chow, N-H., 2015 Jan 1, In : Anti-Cancer Drugs. 26, 4, p. 428-436 9 p.

Research output: Contribution to journalArticle

Urinary Bladder Neoplasms
SCID Mice
Justicia
Neoplasms
Cell Proliferation
12 Citations (Scopus)

Hepatitis B virus pre-S2 mutant induces aerobic glycolysis through mammalian target of rapamycin signal cascade

Teng, C. F., Hsieh, W. C., Wu, H. C., Lin, Y-J., Tsai, H-W., Huang, W-Y. & Su, I. J., 2015 Apr 24, In : PloS one. 10, 4, e0122373.

Research output: Contribution to journalArticle

Hepatitis B virus
glycolysis
Glycolysis
Sirolimus
Viruses
16 Citations (Scopus)

Hepatitis B virus pre-S2 mutant large surface protein inhibits DNA double-strand break repair and leads to genome instability in hepatocarcinogenesis

Hsieh, Y. H., Chang, Y. Y., Su, I. J., Yen, C-J., Liu, Y. R., Liu, R. J., Hsieh, W. C., Tsai, H-W., Wang, L. H. C. & Huang, W-Y., 2015 Jul 1, In : Journal of Pathology. 236, 3, p. 337-347 11 p.

Research output: Contribution to journalArticle

Double-Stranded DNA Breaks
Genomic Instability
Hepatitis B virus
Membrane Proteins
Karyopherins
14 Citations (Scopus)

Membrane-Bound Thrombomodulin Regulates Macrophage Inflammation in Abdominal Aortic Aneurysm

Wang, K. C., Li, Y. H., Shi, G. Y., Tsai, H. W., Luo, C. Y., Cheng, M. H., Ma, C. Y., Hsu, Y. Y., Cheng, T. L., Chang, B. I., Lai, C. H. & Wu, H. L., 2015 Nov 1, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 35, 11, p. 2412-2422 11 p.

Research output: Contribution to journalArticle

Thrombomodulin
Abdominal Aortic Aneurysm
Macrophages
Inflammation
Membranes
16 Citations (Scopus)

Proton-Pump Inhibitor Exposure Aggravates Clostridium difficile-Associated Colitis: Evidence from a Mouse Model

Hung, Y. P., Ko, W. C., Chou, P. H., Chen, Y. H., Lin, H. J., Liu, Y. H., Tsai, H. W., Lee, J. C. & Tsai, P. J., 2015 Aug 15, In : Journal of Infectious Diseases. 212, 4, p. 654-663 10 p.

Research output: Contribution to journalArticle

Clostridium difficile
Proton Pump Inhibitors
Colitis
Clostridium Infections
Pseudomembranous Enterocolitis
17 Citations (Scopus)
Transforming Growth Factors
Superoxides
Hepatocellular Carcinoma
Cells
Hep G2 Cells
2 Citations (Scopus)

TRC8 downregulation contributes to the development of non-alcoholic steatohepatitis by exacerbating hepatic endoplasmic reticulum stress

Chang, P. C., Tsai, H. W., Chiang, M. T., Huang, P. L., Shyue, S. K. & Chau, L. Y., 2015 Nov 1, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1852, 11, p. 2339-2351 13 p.

Research output: Contribution to journalArticle

Endoplasmic Reticulum Stress
Fatty Liver
Down-Regulation
Choline
Methionine
15 Citations (Scopus)

Upregulation of MicroRNA-19b predicts good prognosis in patients with hepatocellular carcinoma presenting with vascular invasion or multifocal disease

Hung, C. L., Yen, C. S., Tsai, H-W., Su, Y. C. & Yen, C-J., 2015 Oct 9, In : BMC Cancer. 15, 1, 665.

Research output: Contribution to journalArticle

MicroRNAs
Blood Vessels
Hepatocellular Carcinoma
Up-Regulation
Mitogen-Activated Protein Kinase 14
2014
2 Citations (Scopus)

An electromagnetic thermotherapy system with a deep penetration depth for percutaneous thermal ablation

Huang, S. C., Chang, Y. Y., Kang, J. W., Tsai, H. W., Shan, Y. S., Lin, X. Z. & Lee, G. B., 2014 Jan 1, In : Annals of biomedical engineering. 42, 1, p. 86-96 11 p.

Research output: Contribution to journalArticle

Ablation
Needles
Electromagnetic fields
Animals
Tissue
8 Citations (Scopus)

Anti-apoptotic effects of osteopontin through the up-regulation of Mcl-1 in gastrointestinal stromal tumors

Hsu, K. H., Tsai, H-W., Lin, P. W., Hsu, Y. S., Lu, P-J. & Shan, Y-S., 2014 Jun 20, In : World Journal of Surgical Oncology. 12, 1, 189.

Research output: Contribution to journalArticle

Gastrointestinal Stromal Tumors
Osteopontin
Up-Regulation
Catenins
Apoptosis
6 Citations (Scopus)

Efficacy of entecavir in chronic hepatitis B patients with persistently normal alanine aminotransferase: Randomized, double-blind, placebo-controlled study

Tseng, K. C., Chen, C. Y., Tsai, H-W., Chang, T-T., Chuang, W. L., Hsu, P. I., Liu, W. C. & Cheng, P-N., 2014 Jan 1, In : Antiviral Therapy. 19, 8, p. 755-764 10 p.

Research output: Contribution to journalArticle

Chronic Hepatitis B
Alanine Transaminase
Placebos
DNA
Histology
2 Citations (Scopus)

Electromagnetic thermotherapy for deep organ ablation by using a needle array under a synchronized-coil system

Huang, S. C., Kang, J-W., Tsai, H-W., Shan, Y-S., Lin, X-Z. & Lee, G. B., 2014 Nov 1, In : IEEE Transactions on Biomedical Engineering. 61, 11, p. 2733-2739 7 p., 6860281.

Research output: Contribution to journalArticle

Ablation
Needles
Electromagnetic fields
Surgery
Tumors
4 Citations (Scopus)

Electromagnetic thermotherapy system with needle arrays: A practical tool for the removal of cancerous tumors

Huang, S. C., Kang, J-W., Tsai, H-W., Shan, Y-S., Lin, X-Z. & Lee, G. B., 2014 Feb, In : IEEE Transactions on Biomedical Engineering. 61, 2, p. 598-605 8 p., 6645388.

Research output: Contribution to journalArticle

Needles
Tumors
Oncology
Medical applications
Ablation
19 Citations (Scopus)

Ground-glass hepatocytes co-expressing hepatitis B virus X protein and surface antigens exhibit enhanced oncogenic effects and tumorigenesis

Wu, H. C., Tsai, H-W., Teng, C. F., Hsieh, W. C., Lin, Y-J., Wang, L. H. C., Yuan, Q. & Su, I. J., 2014 Jan 1, In : Human Pathology. 45, 6, p. 1294-1301 8 p.

Research output: Contribution to journalArticle

Surface Antigens
Glass
Hepatocytes
Carcinogenesis
Mitogen-Activated Protein Kinase 3
3 Citations (Scopus)
Chronic Hepatitis B
Hepatitis B Surface Antigens
Liver
Hepatitis B e Antigens
Mutation
2 Citations (Scopus)

Pathogenesis of virus-associated human cancers: Epstein-Barr virus and hepatitis B virus as two examples

Chang, K-C., Chang, Y., Wang, L. H. C., Tsai, H-W., Huang, W-Y. & Su, I. J., 2014 Jan 1, In : Journal of the Formosan Medical Association. 113, 9, p. 581-590 10 p.

Research output: Contribution to journalReview article

Human Herpesvirus 4
Hodgkin Disease
Hepatitis B virus
Viruses
Endoplasmic Reticulum Stress
32 Citations (Scopus)

The emerging role of hepatitis B virus Pre-S2 deletion mutant proteins in HBV tumorigenesis

Su, I. J., Wang, L. H. C., Hsieh, W. C., Wu, H. C., Teng, C. F., Tsai, H-W. & Huang, W-Y., 2014 Jan 1, In : Journal of biomedical science. 21, 1, 98.

Research output: Contribution to journalReview article

Mutant Proteins
Endoplasmic Reticulum Stress
Viruses
Hepatitis B virus
Carcinogenesis
2013
9 Citations (Scopus)
Hepatitis B e Antigens
Chronic Hepatitis B
Hepatitis B Surface Antigens
Histology
Liver
2 Citations (Scopus)

Cystic tuberculous pericarditis

Lin, T-W., Tsai, M. D., Roan, J-N., Tsai, H-W., Yan, J. J. & Luo, C-Y., 2013 Oct 8, In : Journal of the American College of Cardiology. 62, 15, 1 p.

Research output: Contribution to journalArticle

Tuberculous Pericarditis
CA-125 Antigen
Antitubercular Agents
Pericardium
Combination Drug Therapy
16 Citations (Scopus)

Histone deacetylase inhibitor suberoylanilide hydroxamic acid suppresses the pro-oncogenic effects induced by hepatitis b virus pre-S2 mutant oncoprotein and represents a potential chemopreventive agent in high-risk chronic HBV patients

Hsieh, Y. H., Su, I. J., Yen, C-J., Tsai, T. F., Tsai, H-W., Tsai, H. N., Huang, Y. J., Chen, Y. Y., Ai, Y. L., Kao, L. Y., Hsieh, W. C., Wu, H. C. & Huang, W-Y., 2013 Feb 1, In : Carcinogenesis. 34, 2, p. 475-485 11 p.

Research output: Contribution to journalArticle

Hepatitis Viruses
Histone Deacetylase Inhibitors
Oncogene Proteins
Chronic Hepatitis B
Hepatitis B virus
16 Citations (Scopus)

Identification of novel tumor markers for oral squamous cell carcinoma using glycoproteomic analysis

Chen, Y. T., Chong, Y. M., Cheng, C. W., Ho, C-L., Tsai, H-W., Kasten, F. H., Chen, Y. L. & Chang, C-F., 2013 Jan 1, In : Clinica Chimica Acta. 420, p. 45-53 9 p.

Research output: Contribution to journalArticle

Tumor Biomarkers
Polysaccharides
Squamous Cell Carcinoma
Keratinocytes
Fucosyltransferases
31 Citations (Scopus)

Lin28B is an oncofetal circulating cancer stem cell-like marker associated with recurrence of hepatocellular carcinoma

Cheng, S. W., Tsai, H. W., Lin, Y. J., Cheng, P. N., Chang, Y. C., Yen, C. J., Huang, H. P., Chuang, Y. P., Chang, T. T., Lee, C. T., Chao, A., Chou, C. Y., Chan, S. H., Chow, N. H. & Ho, C. L., 2013 Nov 14, In : PloS one. 8, 11, e80053.

Research output: Contribution to journalArticle

Neoplastic Stem Cells
hepatoma
Stem cells
stem cells
Tumors
1 Citation (Scopus)

Partial nephrectomy without renal ischemia using an electromagnetic thermal surgery system in a porcine model

Ou, C. H., Yang, W. H., Tsai, H. W., Lee, T. J., Chen, S. Y., Huang, S. C., Chang, Y. Y., Lee, G. B. & Lin, X. Z., 2013 May 1, In : Urology. 81, 5, p. 1101-1107 7 p.

Research output: Contribution to journalArticle

Electromagnetic Phenomena
Nephrectomy
Swine
Ischemia
Hot Temperature
4 Citations (Scopus)

Successfully seal pancreatic end after thermal distal pancreatectomy using needle arrays in alternating electromagnetic fields

Chao, Y-J., Shan, Y-S., Zuchini, R., Tsai, H-W., Lin, P. W., Lee, G. B. & Lin, X-Z., 2013 Apr 1, In : Surgical Innovation. 20, 2, p. 150-157 8 p.

Research output: Contribution to journalArticle

Pancreatectomy
Electromagnetic Fields
Magnetic Fields
Needles
Hot Temperature
2012
105 Citations (Scopus)

Combination therapy for hepatocellular carcinoma: Additive preclinical efficacy of the HDAC inhibitor panobinostat with sorafenib

Lachenmayer, A., Toffanin, S., Cabellos, L., Alsinet, C., Hoshida, Y., Villanueva, A., Minguez, B., Tsai, H. W., Ward, S. C., Thung, S., Friedman, S. L. & Llovet, J. M., 2012 Jun 1, In : Journal of Hepatology. 56, 6, p. 1343-1350 8 p.

Research output: Contribution to journalArticle

Histone Deacetylases
Hepatocellular Carcinoma
Liver Neoplasms
Heterografts
Therapeutics
3 Citations (Scopus)

Ectomesenchymal chondromyxoid tumor of tongue

Tsai, S. Y., Chang, K-C., Tsai, H-W. & Dds, Y. T., 2012 Oct 1, In : Indian Journal of Pathology and Microbiology. 55, 4, p. 519-520 2 p.

Research output: Contribution to journalArticle

Tongue
Neoplasms
Glial Fibrillary Acidic Protein
Cell Proliferation
38 Citations (Scopus)

Hepatitis B virus X protein upregulates mTOR signaling through IKKβ to increase cell proliferation and VEGF production in hepatocellular carcinoma

Yen, C-J., Lin, Y-J., Yen, C. S., Tsai, H-W., Tsai, T. F., Chang, K. Y., Huang, W. C., Lin, P. W., Chiang, C-W. & Chang, T-T., 2012 Jul 27, In : PloS one. 7, 7, e41931.

Research output: Contribution to journalArticle

IKappaB kinase
vascular endothelial growth factors
Hepatitis B virus
Cell proliferation
production economics
146 Citations (Scopus)

Wnt-pathway activation in two molecular classes of hepatocellular carcinoma and experimental modulation by sorafenib

Lachenmayer, A., Alsinet, C., Savic, R., Cabellos, L., Toffanin, S., Hoshida, Y., Villanueva, A., Minguez, B., Newell, P., Tsai, H-W., Barretina, J., Thung, S., Ward, S. C., Bruix, J., Mazzaferro, V., Schwartz, M., Friedman, S. L. & Llovet, J. M., 2012 Sep 15, In : Clinical Cancer Research. 18, 18, p. 4997-5007 11 p.

Research output: Contribution to journalArticle

Wnt Signaling Pathway
Catenins
Hepatocellular Carcinoma
Liver Neoplasms
Heterografts
2011
38 Citations (Scopus)

A clustered ground-glass hepatocyte pattern represents a new prognostic marker for the recurrence of hepatocellular carcinoma after surgery

Tsai, H-W., Lin, Y-J., Lin, P. W., Wu, H. C., Hsu, K. H., Yen, C-J., Chan, S-H., Huang, W-Y. & Su, I. J., 2011 Jul 1, In : Cancer. 117, 13, p. 2951-2960 10 p.

Research output: Contribution to journalArticle

Hepatitis B virus
Glass
Hepatocytes
Hepatocellular Carcinoma
Hepatitis B Surface Antigens