Hung-Ying Kao

Visiting Professor

  • 5263 Citations
  • 29 h-Index
1992 …2018
If you made any changes in Pure these will be visible here soon.

Research Output 1992 2018

2018
5 Citations (Scopus)

ACTN4 regulates the stability of RIPK1 in melanoma

Zhang, Y. Y., Tabataba, H., Liu, X. Y., Wang, J. Y., Yan, X. G., Farrelly, M., Jiang, C. C., Guo, S. T., Liu, T., Kao, H-Y., Thorne, R. F., Zhang, X. D. & Jin, L., 2018 Jul 19, In : Oncogene. 37, 29, p. 4033-4045 13 p.

Research output: Contribution to journalArticle

Receptor-Interacting Protein Serine-Threonine Kinases
Actinin
Protein Kinases
Melanoma
Inhibitor of Apoptosis Proteins
Open Access
Publications
Tumors
Neoplasms
7 Citations (Scopus)

Multidomain architecture of estrogen receptor reveals interfacial cross-talk between its DNA-binding and ligand-binding domains

Huang, W., Peng, Y., Kiselar, J., Zhao, X., Albaqami, A., Mendez, D., Chen, Y., Chakravarthy, S., Gupta, S., Ralston, C., Kao, H. Y., Chance, M. R. & Yang, S., 2018 Dec 1, In : Nature communications. 9, 1, 3520.

Research output: Contribution to journalArticle

Open Access
estrogens
Estrogen Receptors
deoxyribonucleic acid
Ligands
ligands
8 Citations (Scopus)

PML: Regulation and multifaceted function beyond tumor suppression

Hsu, K. S. & Kao, H. Y., 2018 Jan 25, In : Cell and Bioscience. 8, 1, 5.

Research output: Contribution to journalReview article

Open Access
Tumors
Neoplasms
Proteins
Nuclear Proteins
Cell Aging
3 Citations (Scopus)

The p53-S100A2 Positive Feedback Loop Negatively Regulates Epithelialization in Cutaneous Wound Healing

Pan, S. C., Li, C. Y., Kuo, C. Y., Kuo, Y. Z., Fang, W. Y., Huang, Y. H., Hsieh, T. C., Kao, H. Y., Kuo, Y., Kang, Y. R., Tsai, W. C., Tsai, S. T. & Wu, L. W., 2018 Dec 1, In : Scientific reports. 8, 1, 5458.

Research output: Contribution to journalArticle

Wound Healing
Skin
Wounds and Injuries
Keratinocytes
Re-Epithelialization
2017
4 Citations (Scopus)

Dual regulation of Stat1 and Stat3 by the tumor suppressor protein PML contributes to interferon α-mediated inhibition of angiogenesis

Hsu, K. S., Zhao, X., Cheng, X., Guan, D., Mahabeleshwar, G. H., Liu, Y., Borden, E., Jain, M. K. & Kao, H-Y., 2017 Jun 16, In : Journal of Biological Chemistry. 292, 24, p. 10048-10060 13 p.

Research output: Contribution to journalArticle

Open Access
Tumor Suppressor Proteins
Endothelial cells
Interferons
Endothelial Cells
Ubiquitination
10 Citations (Scopus)

α actinin 4 (ACTN4) regulates glucocorticoid receptor-mediated transactivation and transrepression in podocytes

Zhao, X., Khurana, S., Charkraborty, S., Tian, Y., Sedor, J. R., Bruggman, L. A. & Kao, H. Y., 2017 Feb 3, In : Journal of Biological Chemistry. 292, 5, p. 1637-1647 11 p.

Research output: Contribution to journalArticle

Open Access
Actinin
Podocytes
Glucocorticoid Receptors
Transcriptional Activation
Glucocorticoids
2016
9 Citations (Scopus)

A signaling network controlling androgenic repression of c-Fos protein in prostate adenocarcinoma cells

Shankar, E., Song, K., Corum, S. L., Bane, K. L., Wang, H., Kao, H-Y. & Danielpour, D., 2016 Mar 11, In : Journal of Biological Chemistry. 291, 11, p. 5512-5526 15 p.

Research output: Contribution to journalArticle

Open Access
Proto-Oncogene Proteins c-fos
Tetradecanoylphorbol Acetate
Androgens
Prostate
Adenocarcinoma
14 Citations (Scopus)

Translational control of PML contributes to TNFα-induced apoptosis of MCF7 breast cancer cells and decreased angiogenesis in HUVECs

Hsu, K. S., Guan, B. J., Cheng, X., Guan, D., Lam, M., Hatzoglou, M. & Kao, H-Y., 2016 Mar 1, In : Cell Death and Differentiation. 23, 3, p. 469-483 15 p.

Research output: Contribution to journalArticle

Open Access
Leukemia
Tumor Necrosis Factor-alpha
Apoptosis
Breast Neoplasms
90-kDa Ribosomal Protein S6 Kinases
2015
1 Citation (Scopus)
6 Citations (Scopus)

Novel vitamin D receptor mutations in hereditary vitamin D resistant rickets in Chinese

Lim, L. M., Zhao, X., Chao, M. C., Chang, J. M., Chang, W. C., Kao, H-Y., Hwang, D. Y. & Chen, H. C., 2015 Sep 30, In : PloS one. 10, 9, e0138152.

Research output: Contribution to journalArticle

Open Access
Familial Hypophosphatemic Rickets
rickets
Rickets
Calcitriol Receptors
vitamin D
4 Citations (Scopus)

The actinin family proteins: Biological function and clinical implications

Kao, H. Y., 2015 Aug 25, In : Cell and Bioscience. 5, 1, 48.

Research output: Contribution to journalEditorial

Open Access
26 Citations (Scopus)

The function, regulation and therapeutic implications of the tumor suppressor protein, PML

Guan, D. & Kao, H-Y., 2015 Nov 4, In : Cell and Bioscience. 5, 1, 60.

Research output: Contribution to journalReview article

Open Access
Tumor Suppressor Proteins
Proteins
Cells
Therapeutics
Acute Promyelocytic Leukemia
18 Citations (Scopus)

α-actinin 4 potentiates nuclear factor κ-light-chain-enhancer of activated B-cell (NF-κB) activity in podocytes independent of its cytoplasmic actin binding function

Zhao, X., Hsu, K. S., Lim, J. H., Bruggeman, L. A. & Kao, H. Y., 2015 Jan 2, In : Journal of Biological Chemistry. 290, 1, p. 338-349 12 p.

Research output: Contribution to journalArticle

Open Access
Actinin
Podocytes
Actins
B-Lymphocytes
Cells
2014
10 Citations (Scopus)

Control of antioxidative response by the tumor suppressor protein PML through regulating Nrf2 activity

Guo, S., Cheng, X., Lim, J. H., Liu, Y. & Kao, H. Y., 2014 Jan 1, In : Molecular Biology of the Cell. 25, 16, p. 2485-2498 14 p.

Research output: Contribution to journalArticle

Tumor Suppressor Proteins
Reactive Oxygen Species
Oxidants
Promyelocytic Leukemia Protein
Oxidative Stress
18 Citations (Scopus)

Deacetylation of the tumor suppressor protein PML regulates hydrogen peroxide-Induced cell death

Guan, D., Lim, J. H., Peng, L., Liu, Y., Lam, M., Seto, E. & Kao, H. Y., 2014 Jul, In : Cell Death and Disease. 5, 7, e1340.

Research output: Contribution to journalArticle

Open Access
Tumor Suppressor Proteins
Hydrogen Peroxide
Cell Death
Acetylation
HeLa Cells
2013
14 Citations (Scopus)

Ablation of promyelocytic leukemia protein (PML) re-patterns energy balance and protects mice from obesity induced by a western diet

Cheng, X., Guo, S., Liu, Y., Chu, H., Hakimi, P., Berger, N. A., Hanson, R. W. & Kao, H. Y., 2013 Oct 11, In : Journal of Biological Chemistry. 288, 41, p. 29746-29759 14 p.

Research output: Contribution to journalArticle

Open Access
Nutrition
Ablation
Energy balance
Metabolism
Obesity
24 Citations (Scopus)

Alpha-Actinin 4 and Tumorigenesis of Breast Cancer

Hsu, K. S. & Kao, H. Y., 2013, Vitamins and Hormones. Academic Press Inc., p. 323-351 29 p. (Vitamins and Hormones; vol. 93).

Research output: Chapter in Book/Report/Conference proceedingChapter

Actinin
Carcinogenesis
Breast Neoplasms
Mechanical Stress
Chromatin Assembly and Disassembly
3 Citations (Scopus)

Correction: Microarray analyses of glucocorticoid and vitamin D3 target genes in differentiating cultured human podocytes (PLoS ONE)

Cheng, X., Zhao, X., Khurana, S., Bruggeman, L. A. & Kao, H. Y., 2013 Jun 21, In : PloS one. 8, 6

Research output: Contribution to journalComment/debate

Open Access
7 Citations (Scopus)

Microarray Analyses of Glucocorticoid and Vitamin D3 Target Genes in Differentiating Cultured Human Podocytes

Cheng, X., Zhao, X., Khurana, S., Bruggeman, L. A. & Kao, H-Y., 2013 Apr 4, In : PloS one. 8, 4, e60213.

Research output: Contribution to journalArticle

Open Access
Podocytes
cholecalciferol
Cholecalciferol
dexamethasone
Microarray Analysis
8 Citations (Scopus)

Monoubiquitination of filamin B regulates vascular endothelial growth factor-mediated trafficking of histone deacetylase 7

Su, Y. T., Gao, C., Liu, Y., Guo, S., Wang, A., Wang, B., Erdjument-Bromage, H., Miyagi, M., Tempst, P. & Kao, H-Y., 2013 Apr 1, In : Molecular and Cellular Biology. 33, 8, p. 1546-1560 15 p.

Research output: Contribution to journalArticle

Filamins
Histone Deacetylases
Vascular Endothelial Growth Factor A
Ubiquitination
Protein Kinase C
29 Citations (Scopus)

Post-translational modifications of PML: Consequences and implications

Cheng, X. & Kao, H. Y., 2013 Dec 24, In : Frontiers in Oncology. 2 JAN, Article 00210.

Research output: Contribution to journalReview article

Open Access
Post Translational Protein Processing
Sumoylation
Tumor Suppressor Proteins
Ubiquitination
Acetylation
40 Citations (Scopus)

The epigenetic regulator UHRF1 promotes ubiquitination-mediated degradation of the tumor-suppressor protein promyelocytic leukemia protein

Guan, D., Factor, D., Liu, Y., Wang, Z. & Kao, H-Y., 2013 Aug 15, In : Oncogene. 32, 33, p. 3819-3828 10 p.

Research output: Contribution to journalArticle

Open Access
Tumor Suppressor Proteins
Ubiquitination
Epigenomics
Leukemia
Neoplasms
4 Citations (Scopus)
Open Access
Nuclear Receptor Co-Repressor 2
Transducin
Gene expression
Proteolysis
Tumor Necrosis Factor-alpha
2012
70 Citations (Scopus)

Acetylation of retinal histones in diabetes increases inflammatory proteins: Effects of minocycline and manipulation of histone acetyltransferase (HAT) and histone deacetylase (HDAC)

Kadiyala, C. S. R., Zheng, L., Du, Y., Yohannes, E., Kao, H-Y., Miyagi, M. & Kern, T. S., 2012 Jul 27, In : Journal of Biological Chemistry. 287, 31, p. 25869-25880 12 p.

Research output: Contribution to journalArticle

Open Access
Histone Acetyltransferases
Acetylation
Minocycline
Histone Deacetylases
Medical problems
25 Citations (Scopus)

Familial focal segmental glomerulosclerosis (FSGS)-linked α-actinin 4 (ACTN4) protein mutants lose ability to activate transcription by nuclear hormone receptors

Khurana, S., Chakraborty, S., Lam, M., Liu, Y., Su, Y. T., Zhao, X., Saleem, M. A., Mathieson, P. W., Bruggeman, L. A. & Kao, H-Y., 2012 Apr 6, In : Journal of Biological Chemistry. 287, 15, p. 12027-12035 9 p.

Research output: Contribution to journalArticle

Open Access
Actinin
Focal Segmental Glomerulosclerosis
Mutant Proteins
Transcription
Cytoplasmic and Nuclear Receptors
17 Citations (Scopus)

Identification of a novel LXXLL motif in α-actinin 4-spliced isoform that is critical for its interaction with estrogen receptor α and co-activators

Khurana, S., Chakraborty, S., Zhao, X., Liu, Y., Guan, D., Lam, M., Huang, W., Yang, S. & Kao, H-Y., 2012 Oct 12, In : Journal of Biological Chemistry. 287, 42, p. 35418-35429 12 p.

Research output: Contribution to journalArticle

Open Access
Actinin
Estrogen Receptors
Protein Isoforms
Cytoplasmic and Nuclear Receptors
Ligands
15 Citations (Scopus)
Open Access
Microarray Analysis
Endothelial Cells
Tumor Necrosis Factor-alpha
Promyelocytic Leukemia Protein
Biological Phenomena
10 Citations (Scopus)

Nuclear hormone receptors in podocytes

Khurana, S., Bruggeman, L. A. & Kao, H-Y., 2012 Sep 20, In : Cell and Bioscience. 2, 1, 33.

Research output: Contribution to journalReview article

Open Access
Podocytes
Cytoplasmic and Nuclear Receptors
Ligands
Kidney
DNA sequences
24 Citations (Scopus)
Open Access
Endothelial cells
Interferons
Endothelial Cells
Tumor Necrosis Factor-alpha
STAT1 Transcription Factor
2011
23 Citations (Scopus)
Open Access
Mitogen-Activated Protein Kinase 1
Mitogen-Activated Protein Kinases
Leukemia
Degradation
Phosphorylation
46 Citations (Scopus)

The actin-binding protein, actinin alpha 4 (ACTN4), is a nuclear receptor coactivator that promotes proliferation of MCF-7 breast cancer cells

Khurana, S., Chakraborty, S., Cheng, X., Su, Y. T. & Kao, H. Y., 2011 Jan 21, In : Journal of Biological Chemistry. 286, 3, p. 1850-1859 10 p.

Research output: Contribution to journalArticle

Open Access
Nuclear Receptor Coactivators
Actinin
Microfilament Proteins
Cells
Breast Neoplasms
2010
175 Citations (Scopus)

DNMT1 stability is regulated by proteins coordinating deubiquitination and acetylation-driven ubiquitination

Du, Z., Song, J., Wang, Y., Zhao, Y., Guda, K., Yang, S., Kao, H. Y., Xu, Y., Willis, J., Markowitz, S. D., Sedwick, D., Ewing, R. M. & Wang, Z., 2010 Nov 2, In : Science Signaling. 3, 146, ra80.

Research output: Contribution to journalArticle

Open Access
Acetylation
Ubiquitination
Methyltransferases
Ubiquitin-Specific Proteases
DNA
8 Citations (Scopus)

Histone deacetylase 7 (HDAC7) regulates myocyte migration and differentiation

Gao, C., Liu, Y., Lam, M. & Kao, H-Y., 2010 Oct 1, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1803, 10, p. 1186-1197 12 p.

Research output: Contribution to journalArticle

Open Access
Histone Deacetylases
Muscle Cells
Muscle Development
Actin Cytoskeleton
Myoblasts
47 Citations (Scopus)

Membrane permeable cyclic peptidyl inhibitors against human peptidylprolyl isomer ase pin1

Liu, T., Liu, Y., Kao, H. Y. & Pei, D., 2010 Mar 25, In : Journal of Medicinal Chemistry. 53, 6, p. 2494-2501 8 p.

Research output: Contribution to journalArticle

Cyclic Peptides
Membranes
Peptide Library
Calorimetry
Phosphoproteins
28 Citations (Scopus)

Promyelocytic leukemia protein controls cell migration in response to hydrogen peroxide and insulin-like growth factor-1

Reineke, E. L., Liu, Y. & Kao, H. Y., 2010 Mar 26, In : Journal of Biological Chemistry. 285, 13, p. 9485-9492 8 p.

Research output: Contribution to journalArticle

Open Access
Somatomedins
Hydrogen Peroxide
Cell Movement
Insulin-Like Growth Factor I
Proteins
2009
21 Citations (Scopus)
Open Access
Co-Repressor Proteins
GTP-Binding Proteins
Estrogen Receptors
Nuclear Receptor Co-Repressor 2
Genes
26 Citations (Scopus)

New insights into the functions and regulation of the transcriptional corepressors SMRT and N-CoR

Stanya, K. J. & Kao, H. Y., 2009 Apr 21, In : Cell Division. 4, 7.

Research output: Contribution to journalReview article

Open Access
Co-Repressor Proteins
Thyroid Hormone Receptors
Estrogen Receptor Modulators
Retinoids
Cytoplasmic and Nuclear Receptors
16 Citations (Scopus)

PML: An emerging tumor suppressor and a target with therapeutic potential

Reineke, E. L. & Kao, H. Y., 2009 Jan 1, In : Cancer Therapy. 7, ISSUE A, p. 219-226 8 p.

Research output: Contribution to journalReview article

Neoplasms
Therapeutics
Carcinogenesis
Acute Promyelocytic Leukemia
Cell Cycle Checkpoints
32 Citations (Scopus)

Targeting promyelocytic leukemia protein: A means to regulating PML nuclear bodies

Reineke, E. L. & Kao, H. Y., 2009 Jan 1, In : International Journal of Biological Sciences. 5, 4, p. 366-376 11 p.

Research output: Contribution to journalReview article

Open Access
nuclear proteins
Staphylococcal Protein A
leukemia
targeting
protein
2008
43 Citations (Scopus)

Cdk2 and Pin1 negatively regulate the transcriptional corepressor SMRT

Stanya, K. J., Liu, Y., Means, A. R. & Kao, H. Y., 2008 Oct 6, In : Journal of Cell Biology. 183, 1, p. 49-61 13 p.

Research output: Contribution to journalArticle

Open Access
Co-Repressor Proteins
Phosphorylation
Nuclear Receptor Co-Repressor 2
ErbB-2 Receptor
Peptidylprolyl Isomerase
65 Citations (Scopus)

Degradation of the tumor suppressor PML by Pin1 contributes to the cancer phenotype of breast cancer MDA-MB-231 ce11s

Reineke, E. L., Lam, M., Liu, Q., Liu, Y., Stanya, K. J., Chang, K. S., Means, A. R. & Kao, H. Y., 2008 Feb 1, In : Molecular and Cellular Biology. 28, 3, p. 997-1006 10 p.

Research output: Contribution to journalArticle

Open Access
Tumor Suppressor Proteins
Breast Neoplasms
Phenotype
Sumoylation
Promyelocytic Leukemia Protein
54 Citations (Scopus)

Histone deacetylase 7 promotes PML sumoylation and is essential for PML nuclear body formation

Gao, C., Ho, C. C., Reineke, E., Lam, M., Cheng, X., Stanya, K. J., Liu, Y., Chakraborty, S., Shih, H. M. & Kao, H. Y., 2008 Sep 1, In : Molecular and Cellular Biology. 28, 18, p. 5658-5667 10 p.

Research output: Contribution to journalArticle

Open Access
Sumoylation
Histone Deacetylases
Human Umbilical Vein Endothelial Cells
Promyelocytic Leukemia Protein
Ubiquitin-Protein Ligases
28 Citations (Scopus)

Signal-dependent regulation of transcription by histone deacetylase 7 involves recruitment to promyelocytic leukemia protein nuclear bodies

Gao, C., Cheng, X., Lam, M., Liu, Y., Liu, Q., Chang, K. S. & Kao, H. Y., 2008 Jul 1, In : Molecular Biology of the Cell. 19, 7, p. 3020-3024 5 p.

Research output: Contribution to journalArticle

Histone Deacetylases
MEF2 Transcription Factors
Matrix Metalloproteinase 10
Tumor Necrosis Factor-alpha
Messenger RNA
19 Citations (Scopus)

The Positive Transcription Elongation Factor b Is an Essential Cofactor for the Activation of Transcription by Myocyte Enhancer Factor 2

Nojima, M., Huang, Y., Tyagi, M., Kao, H. Y. & Fujinaga, K., 2008 Oct 3, In : Journal of Molecular Biology. 382, 2, p. 275-287 13 p.

Research output: Contribution to journalArticle

MEF2 Transcription Factors
Peptide Elongation Factors
Transcriptional Activation
Transcription Factors
Cyclin T
62 Citations (Scopus)

VEGF stimulates HDAC7 phosphorylation and cytoplasmic accumulation modulating matrix metalloproteinase expression and angiogenesis

Chang, H. H., Bong, S. J., Kao, H. Y. & Jin, Z. G., 2008 Oct 1, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 28, 10, p. 1782-1788 7 p.

Research output: Contribution to journalArticle

Open Access
Histone Deacetylases
Matrix Metalloproteinases
Vascular Endothelial Growth Factor A
Phosphorylation
Protein Kinases
2007
8 Citations (Scopus)

Aberrant association of promyelocytic leukemia protein-retinoic acid receptor-α with coactivators contributes to its ability to regulate gene expression

Reineke, E. L., Liu, H., Lam, M., Liu, Y. & Kao, H. Y., 2007 Jun 22, In : Journal of Biological Chemistry. 282, 25, p. 18584-18596 13 p.

Research output: Contribution to journalArticle

Open Access
Retinoic Acid Receptors
Gene expression
Association reactions
Gene Expression
Proteins
2006
22 Citations (Scopus)

CRM1 mediates nuclear export of HDAC7 independently of HDAC7 phosphorylation and association with 14-3-3s

Gao, C., Li, X., Lam, M., Liu, Y., Chakraborty, S. & Kao, H-Y., 2006 Sep 18, In : FEBS Letters. 580, 21, p. 5096-5104 9 p.

Research output: Contribution to journalArticle

Open Access
Phosphorylation
Cell Nucleus Active Transport
Cytoplasm
Phospho-Specific Antibodies
Association reactions
55 Citations (Scopus)

α-actinin 4 potentiates myocyte enhancer factor-2 transcription activity by antagonizing histone deacetylase 7

Chakraborty, S., Reineke, E. L., Lam, M., Li, X., Liu, Y., Gao, C., Khurana, S. & Kao, H-Y., 2006 Nov 17, In : Journal of Biological Chemistry. 281, 46, p. 35070-35080 11 p.

Research output: Contribution to journalArticle

Open Access
MEF2 Transcription Factors
Actinin
Histone Deacetylases
Transcription
Association reactions
2004
112 Citations (Scopus)

Ataxin 1, a SCA1 neurodegenerative disorder protein, is functionally linked to the silencing mediator of retinoid and thyroid hormone receptors

Tsai, C. C., Kao, H. Y., Mitzutani, A., Banayo, E., Rajan, H., McKeown, M. & Evans, R. M., 2004 Mar 23, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 12, p. 4047-4052 6 p.

Research output: Contribution to journalArticle

Open Access
Spinocerebellar Ataxias
Thyroid Hormone Receptors
Retinoids
Neurodegenerative Diseases
Proteins