Hung-Ying Kao

Visiting Professor

  • 5391 Citations
  • 30 h-Index
1992 …2020

Research output per year

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Research Output

2020

The promyelocytic leukemia protein isoform PML1 is an oncoprotein and a direct target of the antioxidant sulforaphane (SFN)

Alhazmi, N., Pai, C. P., Albaqami, A., Wang, H., Zhao, X., Chen, M., Hu, P., Guo, S., Starost, K., Hajihassani, O., Miyagi, M. & Kao, H. Y., 2020 Aug 1, In : Biochimica et biophysica acta. Molecular cell research. 1867, 8, 1 p.

Research output: Contribution to journalArticle

Open Access

The tumor suppressor TGFBR3 blocks lymph node metastasis in head and neck cancer

Fang, W. Y., Kuo, Y. Z., Chang, J. Y., Hsiao, J. R., Kao, H. Y., Tsai, S. T. & Wu, L. W., 2020 Jun, In : Cancers. 12, 6, 1375.

Research output: Contribution to journalArticle

Open Access
2019

Cancer-associated fibroblast-derived interleukin-1β activates protumor C-C motif chemokine ligand 22 signaling in head and neck cancer

Huang, Y. H., Chang, C. Y., Kuo, Y. Z., Fang, W. Y., Kao, H. Y., Tsai, S. T. & Wu, L. W., 2019 Sep 1, In : Cancer Science. 110, 9, p. 2783-2793 11 p.

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)
2018

ACTN4 regulates the stability of RIPK1 in melanoma

Zhang, Y. Y., Tabataba, H., Liu, X. Y., Wang, J. Y., Yan, X. G., Farrelly, M., Jiang, C. C., Guo, S. T., Liu, T., Kao, H. Y., Thorne, R. F., Zhang, X. D. & Jin, L., 2018 Jul 19, In : Oncogene. 37, 29, p. 4033-4045 13 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)
Open Access

Multidomain architecture of estrogen receptor reveals interfacial cross-talk between its DNA-binding and ligand-binding domains

Huang, W., Peng, Y., Kiselar, J., Zhao, X., Albaqami, A., Mendez, D., Chen, Y., Chakravarthy, S., Gupta, S., Ralston, C., Kao, H. Y., Chance, M. R. & Yang, S., 2018 Dec 1, In : Nature communications. 9, 1, 3520.

Research output: Contribution to journalArticle

Open Access
14 Citations (Scopus)

PML: Regulation and multifaceted function beyond tumor suppression

Hsu, K. S. & Kao, H. Y., 2018 Jan 25, In : Cell and Bioscience. 8, 1, 5.

Research output: Contribution to journalReview article

Open Access
14 Citations (Scopus)

The p53-S100A2 Positive Feedback Loop Negatively Regulates Epithelialization in Cutaneous Wound Healing

Pan, S. C., Li, C. Y., Kuo, C. Y., Kuo, Y. Z., Fang, W. Y., Huang, Y. H., Hsieh, T. C., Kao, H. Y., Kuo, Y., Kang, Y. R., Tsai, W. C., Tsai, S. T. & Wu, L. W., 2018 Dec 1, In : Scientific reports. 8, 1, 5458.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2017

Dual regulation of Stat1 and Stat3 by the tumor suppressor protein PML contributes to interferon α-mediated inhibition of angiogenesis

Hsu, K. S., Zhao, X., Cheng, X., Guan, D., Mahabeleshwar, G. H., Liu, Y., Borden, E., Jain, M. K. & Kao, H. Y., 2017 Jun 16, In : Journal of Biological Chemistry. 292, 24, p. 10048-10060 13 p.

Research output: Contribution to journalArticle

Open Access
6 Citations (Scopus)

α actinin 4 (ACTN4) regulates glucocorticoid receptor-mediated transactivation and transrepression in podocytes

Zhao, X., Khurana, S., Charkraborty, S., Tian, Y., Sedor, J. R., Bruggman, L. A. & Kao, H. Y., 2017 Feb 3, In : Journal of Biological Chemistry. 292, 5, p. 1637-1647 11 p.

Research output: Contribution to journalArticle

Open Access
13 Citations (Scopus)
2016

A signaling network controlling androgenic repression of c-Fos protein in prostate adenocarcinoma cells

Shankar, E., Song, K., Corum, S. L., Bane, K. L., Wang, H., Kao, H. Y. & Danielpour, D., 2016 Mar 11, In : Journal of Biological Chemistry. 291, 11, p. 5512-5526 15 p.

Research output: Contribution to journalArticle

Open Access
9 Citations (Scopus)

Translational control of PML contributes to TNFα-induced apoptosis of MCF7 breast cancer cells and decreased angiogenesis in HUVECs

Hsu, K. S., Guan, B. J., Cheng, X., Guan, D., Lam, M., Hatzoglou, M. & Kao, H. Y., 2016 Mar 1, In : Cell Death and Differentiation. 23, 3, p. 469-483 15 p.

Research output: Contribution to journalArticle

Open Access
14 Citations (Scopus)
2015
1 Citation (Scopus)

Novel vitamin D receptor mutations in hereditary vitamin D resistant rickets in Chinese

Lim, L. M., Zhao, X., Chao, M. C., Chang, J. M., Chang, W. C., Kao, H-Y., Hwang, D. Y. & Chen, H. C., 2015 Sep 30, In : PloS one. 10, 9, e0138152.

Research output: Contribution to journalArticle

Open Access
6 Citations (Scopus)

The actinin family proteins: Biological function and clinical implications

Kao, H. Y., 2015 Aug 25, In : Cell and Bioscience. 5, 1, 48.

Research output: Contribution to journalEditorial

Open Access
4 Citations (Scopus)

The function, regulation and therapeutic implications of the tumor suppressor protein, PML

Guan, D. & Kao, H. Y., 2015 Nov 4, In : Cell and Bioscience. 5, 1, 60.

Research output: Contribution to journalReview article

Open Access
30 Citations (Scopus)

α-actinin 4 potentiates nuclear factor κ-light-chain-enhancer of activated B-cell (NF-κB) activity in podocytes independent of its cytoplasmic actin binding function

Zhao, X., Hsu, K. S., Lim, J. H., Bruggeman, L. A. & Kao, H. Y., 2015 Jan 2, In : Journal of Biological Chemistry. 290, 1, p. 338-349 12 p.

Research output: Contribution to journalArticle

Open Access
21 Citations (Scopus)
2014

Control of antioxidative response by the tumor suppressor protein PML through regulating Nrf2 activity

Guo, S., Cheng, X., Lim, J. H., Liu, Y. & Kao, H. Y., 2014 Jan 1, In : Molecular Biology of the Cell. 25, 16, p. 2485-2498 14 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Deacetylation of the tumor suppressor protein PML regulates hydrogen peroxide-Induced cell death

Guan, D., Lim, J. H., Peng, L., Liu, Y., Lam, M., Seto, E. & Kao, H. Y., 2014 Jul, In : Cell Death and Disease. 5, 7, e1340.

Research output: Contribution to journalArticle

Open Access
20 Citations (Scopus)
2013

Ablation of promyelocytic leukemia protein (PML) re-patterns energy balance and protects mice from obesity induced by a western diet

Cheng, X., Guo, S., Liu, Y., Chu, H., Hakimi, P., Berger, N. A., Hanson, R. W. & Kao, H. Y., 2013 Oct 11, In : Journal of Biological Chemistry. 288, 41, p. 29746-29759 14 p.

Research output: Contribution to journalArticle

Open Access
15 Citations (Scopus)

Alpha-Actinin 4 and Tumorigenesis of Breast Cancer

Hsu, K. S. & Kao, H. Y., 2013, Vitamins and Hormones. Academic Press Inc., p. 323-351 29 p. (Vitamins and Hormones; vol. 93).

Research output: Chapter in Book/Report/Conference proceedingChapter

27 Citations (Scopus)

Correction: Microarray analyses of glucocorticoid and vitamin D3 target genes in differentiating cultured human podocytes (PLoS ONE)

Cheng, X., Zhao, X., Khurana, S., Bruggeman, L. A. & Kao, H. Y., 2013 Jun 21, In : PloS one. 8, 6

Research output: Contribution to journalComment/debate

Open Access
3 Citations (Scopus)

Microarray Analyses of Glucocorticoid and Vitamin D3 Target Genes in Differentiating Cultured Human Podocytes

Cheng, X., Zhao, X., Khurana, S., Bruggeman, L. A. & Kao, H. Y., 2013 Apr 4, In : PloS one. 8, 4, e60213.

Research output: Contribution to journalArticle

Open Access
8 Citations (Scopus)

Monoubiquitination of filamin B regulates vascular endothelial growth factor-mediated trafficking of histone deacetylase 7

Su, Y. T., Gao, C., Liu, Y., Guo, S., Wang, A., Wang, B., Erdjument-Bromage, H., Miyagi, M., Tempst, P. & Kao, H. Y., 2013 Apr 1, In : Molecular and Cellular Biology. 33, 8, p. 1546-1560 15 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Post-translational modifications of PML: Consequences and implications

Cheng, X. & Kao, H. Y., 2013 Dec 24, In : Frontiers in Oncology. 2 JAN, Article 00210.

Research output: Contribution to journalReview article

Open Access
30 Citations (Scopus)

The epigenetic regulator UHRF1 promotes ubiquitination-mediated degradation of the tumor-suppressor protein promyelocytic leukemia protein

Guan, D., Factor, D., Liu, Y., Wang, Z. & Kao, H. Y., 2013 Aug 15, In : Oncogene. 32, 33, p. 3819-3828 10 p.

Research output: Contribution to journalArticle

Open Access
43 Citations (Scopus)
Open Access
4 Citations (Scopus)
2012

Acetylation of retinal histones in diabetes increases inflammatory proteins: Effects of minocycline and manipulation of histone acetyltransferase (HAT) and histone deacetylase (HDAC)

Kadiyala, C. S. R., Zheng, L., Du, Y., Yohannes, E., Kao, H. Y., Miyagi, M. & Kern, T. S., 2012 Jul 27, In : Journal of Biological Chemistry. 287, 31, p. 25869-25880 12 p.

Research output: Contribution to journalArticle

Open Access
72 Citations (Scopus)

Familial focal segmental glomerulosclerosis (FSGS)-linked α-actinin 4 (ACTN4) protein mutants lose ability to activate transcription by nuclear hormone receptors

Khurana, S., Chakraborty, S., Lam, M., Liu, Y., Su, Y. T., Zhao, X., Saleem, M. A., Mathieson, P. W., Bruggeman, L. A. & Kao, H. Y., 2012 Apr 6, In : Journal of Biological Chemistry. 287, 15, p. 12027-12035 9 p.

Research output: Contribution to journalArticle

Open Access
27 Citations (Scopus)

Identification of a novel LXXLL motif in α-actinin 4-spliced isoform that is critical for its interaction with estrogen receptor α and co-activators

Khurana, S., Chakraborty, S., Zhao, X., Liu, Y., Guan, D., Lam, M., Huang, W., Yang, S. & Kao, H. Y., 2012 Oct 12, In : Journal of Biological Chemistry. 287, 42, p. 35418-35429 12 p.

Research output: Contribution to journalArticle

Open Access
18 Citations (Scopus)
Open Access
15 Citations (Scopus)

Nuclear hormone receptors in podocytes

Khurana, S., Bruggeman, L. A. & Kao, H. Y., 2012 Sep 20, In : Cell and Bioscience. 2, 1, 33.

Research output: Contribution to journalReview article

Open Access
11 Citations (Scopus)
Open Access
24 Citations (Scopus)
2011
Open Access
25 Citations (Scopus)

The actin-binding protein, actinin alpha 4 (ACTN4), is a nuclear receptor coactivator that promotes proliferation of MCF-7 breast cancer cells

Khurana, S., Chakraborty, S., Cheng, X., Su, Y. T. & Kao, H. Y., 2011 Jan 21, In : Journal of Biological Chemistry. 286, 3, p. 1850-1859 10 p.

Research output: Contribution to journalArticle

Open Access
52 Citations (Scopus)
2010

DNMT1 stability is regulated by proteins coordinating deubiquitination and acetylation-driven ubiquitination

Du, Z., Song, J., Wang, Y., Zhao, Y., Guda, K., Yang, S., Kao, H. Y., Xu, Y., Willis, J., Markowitz, S. D., Sedwick, D., Ewing, R. M. & Wang, Z., 2010 Nov 2, In : Science Signaling. 3, 146, ra80.

Research output: Contribution to journalArticle

Open Access
180 Citations (Scopus)

Histone deacetylase 7 (HDAC7) regulates myocyte migration and differentiation

Gao, C., Liu, Y., Lam, M. & Kao, H. Y., 2010 Oct 1, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1803, 10, p. 1186-1197 12 p.

Research output: Contribution to journalArticle

Open Access
8 Citations (Scopus)

Membrane permeable cyclic peptidyl inhibitors against human peptidylprolyl isomer ase pin1

Liu, T., Liu, Y., Kao, H. Y. & Pei, D., 2010 Mar 25, In : Journal of Medicinal Chemistry. 53, 6, p. 2494-2501 8 p.

Research output: Contribution to journalArticle

49 Citations (Scopus)

Promyelocytic leukemia protein controls cell migration in response to hydrogen peroxide and insulin-like growth factor-1

Reineke, E. L., Liu, Y. & Kao, H. Y., 2010 Mar 26, In : Journal of Biological Chemistry. 285, 13, p. 9485-9492 8 p.

Research output: Contribution to journalArticle

Open Access
29 Citations (Scopus)
2009
Open Access
22 Citations (Scopus)

New insights into the functions and regulation of the transcriptional corepressors SMRT and N-CoR

Stanya, K. J. & Kao, H. Y., 2009 Apr 21, In : Cell Division. 4, 7.

Research output: Contribution to journalReview article

Open Access
28 Citations (Scopus)

PML: An emerging tumor suppressor and a target with therapeutic potential

Reineke, E. L. & Kao, H. Y., 2009 Jan 1, In : Cancer Therapy. 7, ISSUE A, p. 219-226 8 p.

Research output: Contribution to journalReview article

16 Citations (Scopus)

Targeting promyelocytic leukemia protein: A means to regulating PML nuclear bodies

Reineke, E. L. & Kao, H. Y., 2009 Jan 1, In : International Journal of Biological Sciences. 5, 4, p. 366-376 11 p.

Research output: Contribution to journalReview article

Open Access
32 Citations (Scopus)
2008

Cdk2 and Pin1 negatively regulate the transcriptional corepressor SMRT

Stanya, K. J., Liu, Y., Means, A. R. & Kao, H. Y., 2008 Oct 6, In : Journal of Cell Biology. 183, 1, p. 49-61 13 p.

Research output: Contribution to journalArticle

Open Access
46 Citations (Scopus)

Degradation of the tumor suppressor PML by Pin1 contributes to the cancer phenotype of breast cancer MDA-MB-231 ce11s

Reineke, E. L., Lam, M., Liu, Q., Liu, Y., Stanya, K. J., Chang, K. S., Means, A. R. & Kao, H. Y., 2008 Feb 1, In : Molecular and Cellular Biology. 28, 3, p. 997-1006 10 p.

Research output: Contribution to journalArticle

Open Access
66 Citations (Scopus)

Histone deacetylase 7 promotes PML sumoylation and is essential for PML nuclear body formation

Gao, C., Ho, C. C., Reineke, E., Lam, M., Cheng, X., Stanya, K. J., Liu, Y., Chakraborty, S., Shih, H. M. & Kao, H. Y., 2008 Sep 1, In : Molecular and Cellular Biology. 28, 18, p. 5658-5667 10 p.

Research output: Contribution to journalArticle

Open Access
54 Citations (Scopus)

Signal-dependent regulation of transcription by histone deacetylase 7 involves recruitment to promyelocytic leukemia protein nuclear bodies

Gao, C., Cheng, X., Lam, M., Liu, Y., Liu, Q., Chang, K. S. & Kao, H. Y., 2008 Jul 1, In : Molecular Biology of the Cell. 19, 7, p. 3020-3024 5 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

The Positive Transcription Elongation Factor b Is an Essential Cofactor for the Activation of Transcription by Myocyte Enhancer Factor 2

Nojima, M., Huang, Y., Tyagi, M., Kao, H. Y. & Fujinaga, K., 2008 Oct 3, In : Journal of Molecular Biology. 382, 2, p. 275-287 13 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

VEGF stimulates HDAC7 phosphorylation and cytoplasmic accumulation modulating matrix metalloproteinase expression and angiogenesis

Chang, H. H., Bong, S. J., Kao, H. Y. & Jin, Z. G., 2008 Oct 1, In : Arteriosclerosis, thrombosis, and vascular biology. 28, 10, p. 1782-1788 7 p.

Research output: Contribution to journalArticle

Open Access
65 Citations (Scopus)
2007

Aberrant association of promyelocytic leukemia protein-retinoic acid receptor-α with coactivators contributes to its ability to regulate gene expression

Reineke, E. L., Liu, H., Lam, M., Liu, Y. & Kao, H. Y., 2007 Jun 22, In : Journal of Biological Chemistry. 282, 25, p. 18584-18596 13 p.

Research output: Contribution to journalArticle

Open Access
8 Citations (Scopus)