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Personal profile


  • 國防醫學院醫學系學士

Research Interests

  • 癌症臨床試驗及抗癌藥物

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

  • 3 Similar Profiles
Neoplasms Medicine & Life Sciences
Cells Chemical Compounds
Tubulin Medicine & Life Sciences
oxaliplatin Medicine & Life Sciences
KB Cells Medicine & Life Sciences
Cell Line Medicine & Life Sciences
Head and Neck Neoplasms Medicine & Life Sciences
Microtubules Medicine & Life Sciences

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Projects 2014 2018

Research Output 1989 2019

1-Arylsulfonyl indoline-benzamides as a new antitubulin agents, with inhibition of histone deacetylase

Lai, M. J., Ojha, R., Lin, M. H., Liu, Y. M., Lee, H. Y., Lin, T. E., Hsu, K. C., Chang, C. Y., Chen, M. C., Nepali, K., Chang, J-Y. & Liou, J. P., 2019 Jan 15, In : European Journal of Medicinal Chemistry. 162, p. 612-630 19 p.

Research output: Contribution to journalArticle

Histone Deacetylases
Inhibitory Concentration 50

Alpha-tubulin acetyltransferase/MEC-17 regulates cancer cell migration and invasion through epithelial–mesenchymal transition suppression and cell polarity disruption

Lee, C. C., Cheng, Y. C., Chang, C. Y., Lin, C. M. & Chang, J-Y., 2018 Dec 1, In : Scientific Reports. 8, 1, 17477.

Research output: Contribution to journalArticle

Cell Polarity
Cell Movement

Correction: 2-Aroylquinoline-5,8-diones as potent anticancer agents displaying tubulin and heat shock protein 90 (HSP90) inhibition (Org. Biomol. Chem. (2016) 14 (716-723))

Nepali, K., Kumar, S., Huang, H. L., Kuo, F. C., Lee, C. H., Kuo, C. C., Yeh, T. K., Li, Y. H., Chang, J-Y., Liou, J. P. & Lee, H. Y., 2018 Jan 1, In : Organic and Biomolecular Chemistry. 16, 25, 1 p.

Research output: Contribution to journalComment/debate

HSP90 Heat-Shock Proteins
Antineoplastic Agents

Homoharringtonine induced immune alteration for an Efficient Anti-tumor Response in Mouse Models of Non-small Cell Lung Adenocarcinoma Expressing Kras Mutation

Weng, T. Y., Wu, H. F., Li, C. Y., Hung, Y. H., Chang, Y. W., Chen, Y. L., Hsu, H-P., Chen, Y-H., Wang, C. Y., Chang, J-Y. & Lai, M-D., 2018 Dec 1, In : Scientific Reports. 8, 1, 8216.

Research output: Contribution to journalArticle


Novel microtubule inhibitor MPT0B098 inhibits hypoxia-induced epithelial-to-mesenchymal transition in head and neck squamous cell carcinoma

Tsai, I. T., Kuo, C. C., Liou, J. P. & Chang, J-Y., 2018 Mar 28, In : Journal of Biomedical Science. 25, 1, 28.

Research output: Contribution to journalArticle

Hypoxia-Inducible Factor 1
Epithelial-Mesenchymal Transition
Transforming Growth Factors