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Research Output

2020
Open Access

Pharmacological Inhibition of Cathepsin S Suppresses Abdominal Aortic Aneurysm in Mice

Lai, C. H., Chang, J. Y., Wang, K. C., Lee, F. T., Wu, H. L. & Cheng, T. L., 2020 Jan 1, (Accepted/In press) In : European Journal of Vascular and Endovascular Surgery.

Research output: Contribution to journalArticle

2019

1-Arylsulfonyl indoline-benzamides as a new antitubulin agents, with inhibition of histone deacetylase

Lai, M. J., Ojha, R., Lin, M. H., Liu, Y. M., Lee, H. Y., Lin, T. E., Hsu, K. C., Chang, C. Y., Chen, M. C., Nepali, K., Chang, J-Y. & Liou, J. P., 2019 Jan 15, In : European Journal of Medicinal Chemistry. 162, p. 612-630 19 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
Open Access
2 Citations (Scopus)

Laminin γ2-enriched extracellular vesicles of oral squamous cell carcinoma cells enhance in vitro lymphangiogenesis via integrin α3-dependent uptake by lymphatic endothelial cells

Wang, S. H., Liou, G. G., Liu, S. H., Chang, J. S., Hsiao, J. R., Yen, Y. C., Chen, Y. L., Wu, W. L., Chang, J. Y. & Chen, Y. W., 2019 Jun 1, In : International Journal of Cancer. 144, 11, p. 2795-2810 16 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Lysosomal cysteine protease cathepsin S is involved in cancer cell motility by regulating store-operated Ca2+ entry

Lin, H. H., Chen, S. J., Shen, M. R., Huang, Y. T., Hsieh, H. P., Lin, S. Y., Lin, C. C., Chang, W. S. W. & Chang, J. Y., 2019 Dec, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1866, 12, 118517.

Research output: Contribution to journalArticle

New insights into mechanisms of cisplatin resistance: From tumor cell to microenvironment

Chen, S. H. & Chang, J. Y., 2019 Sep 1, In : International journal of molecular sciences. 20, 17, 4136.

Research output: Contribution to journalReview article

Open Access
7 Citations (Scopus)

Oral hygiene and the overall survival of head and neck cancer patients

Chang, C. C., Lee, W. T., Hsiao, J. R., Ou, C. Y., Huang, C. C., Tsai, S. T., Chen, K. C., Huang, J. S., Wong, T. Y., Lai, Y. H., Wu, Y. H., Hsueh, W. T., Wu, S. Y., Yen, C. J., Chang, J. Y., Lin, C. L., Weng, Y. L., Yang, H. C., Chen, Y. S. & Chang, J. S., 2019 Apr, In : Cancer medicine. 8, 4, p. 1854-1864 11 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

TNF-α-induced miR-450a mediates TMEM182 expression to promote oral squamous cell carcinoma motility

Hsing, E. W., Shiah, S. G., Peng, H. Y., Chen, Y. W., Chuu, C. P., Hsiao, J. R., Lyu, P. C. & Chang, J. Y., 2019 Mar, In : PloS one. 14, 3, e0213463.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Validation of Alcohol Flushing Questionnaire to Identify ALDH2 Status in a Case–Control Study of Head and Neck Cancer

Hsiao, J-R., Lee, W-T., Ou, C-Y., Huang, C-C., Chang, C-C., Tsai, S-T., Chen, K-C., Huang, J-S., Wang, D-Y., Lai, Y-H., Wu, Y-H., Hsueh, W-T., Wu, S-Y., Yen, C-J., Chang, J-Y., Lin, C. L., Weng, Y. L., Yang, H. C., Chen, Y. S. & Chang, J. S., 2019 Jun 1, In : Alcoholism: Clinical and Experimental Research. 43, 6, p. 1225-1233 9 p.

Research output: Contribution to journalReview article

2018
1 Citation (Scopus)

Correction: 2-Aroylquinoline-5,8-diones as potent anticancer agents displaying tubulin and heat shock protein 90 (HSP90) inhibition (Org. Biomol. Chem. (2016) 14 (716-723))

Nepali, K., Kumar, S., Huang, H. L., Kuo, F. C., Lee, C. H., Kuo, C. C., Yeh, T. K., Li, Y. H., Chang, J. Y., Liou, J. P. & Lee, H. Y., 2018 Jan 1, In : Organic and Biomolecular Chemistry. 16, 25, 1 p.

Research output: Contribution to journalComment/debate

Homoharringtonine induced immune alteration for an Efficient Anti-tumor Response in Mouse Models of Non-small Cell Lung Adenocarcinoma Expressing Kras Mutation

Weng, T. Y., Wu, H. F., Li, C. Y., Hung, Y. H., Chang, Y. W., Chen, Y. L., Hsu, H. P., Chen, Y. H., Wang, C. Y., Chang, J. Y. & Lai, M. D., 2018 Dec 1, In : Scientific reports. 8, 1, 8216.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Novel microtubule inhibitor MPT0B098 inhibits hypoxia-induced epithelial-to-mesenchymal transition in head and neck squamous cell carcinoma

Tsai, I. T., Kuo, C. C., Liou, J. P. & Chang, J. Y., 2018 Mar 28, In : Journal of biomedical science. 25, 1, 28.

Research output: Contribution to journalArticle

4 Citations (Scopus)

The interplay between oral microbiome, lifestyle factors and genetic polymorphisms in the risk of oral squamous cell carcinoma

Hsiao, J-R., Chang, C-C., Lee, W-T., Huang, C-C., Ou, C-Y., Tsai, S-T., Chen, K-C., Huang, J-S., Wang, D-Y., Lai, Y-H., Wu, Y-H., Hsueh, W-T., Wu, S-Y., Yen, C-J., Chang, J-Y., Lin, C. L., Weng, Y. L., Yang, H. C., Chen, Y. S. & Chang, J. S., 2018 May 28, In : Carcinogenesis. 39, 6, p. 778-787 10 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)
2 Citations (Scopus)
2017

Chronic treatment with cisplatin induces chemoresistance through the TIP60-mediated Fanconi anemia and homologous recombination repair pathways

Su, W. P., Ho, Y. C., Wu, C. K., Hsu, S. H., Shiu, J. L., Huang, J. C., Chang, S. B., Chiu, W. T., Hung, J. J., Liu, T. L., Wu, W. S., Wu, P. Y., Su, W. C., Chang, J. Y. & Liaw, H., 2017 Dec 1, In : Scientific reports. 7, 1, 3879.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Enhanced B-Raf-mediated NRF2 gene transcription and HATs-mediated NRF2 protein acetylation contributes to ABCC1-mediated chemoresistance and glutathione-mediated survival in acquired topoisomerase II poison-resistant cancer cells

Chen, H. H., Chang, H. H., Chang, J. Y., Tang, Y. C., Cheng, Y. C., Lin, L. M., Cheng, S. Y., Huang, C. H., Sun, M. W., Chen, C. T. & Kuo, C. C., 2017 Dec, In : Free Radical Biology and Medicine. 113, p. 505-518 14 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
1 Citation (Scopus)

Hypoxia-induced downregulation of DUSP-2 phosphatase drives colon cancer stemness

Hou, P. C., Li, Y. H., Lin, S. C., Lin, S. C., Lee, J. C., Lin, B. W., Liou, J. P., Chang, J. Y., Kuo, C. C., Liu, Y. M., Sun, H. S. & Tsai, S. J., 2017 Aug 15, In : Cancer Research. 77, 16, p. 4305-4316 12 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Investigating the Association between Alcohol and Risk of Head and Neck Cancer in Taiwan

Huang, C. C., Hsiao, J. R., Lee, W. T., Lee, Y. C., Ou, C. Y., Chang, C. C., Lu, Y. C., Huang, J. S., Wong, T. Y., Chen, K. C., Tsai, S. T., Fang, S. Y., Wu, J. L., Wu, Y. H., Hsueh, W. T., Yen, C. J., Wu, S. Y., Chang, J. Y., Lin, C. L., Wang, Y. H. & 4 others, Weng, Y. L., Yang, H. C., Chen, Y. S. & Chang, J. S., 2017 Dec 1, In : Scientific reports. 7, 1, 9701.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Investigating the association between diet and risk of head and neck cancer in Taiwan

Chang, C. C., Lee, W. T., Lee, Y. C., Huang, C. C., Ou, C. Y., Lin, Y. H., Huang, J. S., Wong, T. Y., Chen, K. C., Hsiao, J. R., Lu, Y. C., Tsai, S. T., Lai, Y. H., Wu, Y. H., Hsueh, W. T., Yen, C. J., Wu, S. Y., Chang, J. Y., Fang, S. Y., Wu, J. L. & 5 others, Lin, C. L., Weng, Y. L., Yang, H. C., Chen, Y. S. & Chang, J. S., 2017 Jan 1, In : Oncotarget. 8, 58, p. 98865-98875 11 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Minoxidil is a potential neuroprotective drug for paclitaxel-induced peripheral neuropathy

Chen, Y. F., Chen, L. H., Yeh, Y. M., Wu, P. Y., Chen, Y. F., Chang, L. Y., Chang, J. Y. & Shen, M. R., 2017 Mar 28, In : Scientific reports. 7, 45366.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Parathyroid Hormone-Like Hormone is a Poor Prognosis Marker of Head and Neck Cancer and Promotes Cell Growth via RUNX2 Regulation

Chang, W. M., Lin, Y. F., Su, C. Y., Peng, H. Y., Chang, Y. C., Hsiao, J. R., Chen, C. L., Chang, J. Y., Shieh, Y. S., Hsiao, M. & Shiah, S. G., 2017 Jan 25, In : Scientific reports. 7, 41131.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Pharmacokinetics and protein binding of MPT0B292

Tien, Y. E., Li, C. J., Liou, J. P., Chang, J. Y. & Huang, J. D., 2017 Jul 1, In : Biopharmaceutics and Drug Disposition. 38, 5, p. 340-350 11 p.

Research output: Contribution to journalArticle

Regular recreational physical activity and risk of head and neck cancer

Lin, C. L., Lee, W. T., Ou, C. Y., Hsiao, J. R., Huang, C. C., Huang, J. S., Wong, T. Y., Chen, K. C., Tsai, S. T., Fang, S. Y., Huang, T. T., Wu, J. L., Wu, Y. H., Hsueh, W. T., Yen, C. J., Lai, Y. H., Liao, H. C., Wu, S. Y., Yang, M. W., Lin, F. C. & 6 others, Chang, J. Y., Wang, Y. H., Weng, Y. L., Yang, H. C., Chen, Y. S. & Chang, J. S., 2017 Apr 21, In : BMC cancer. 17, 1, 286.

Research output: Contribution to journalArticle

Skin Delivery of Clec4a Small Hairpin RNA Elicited an Effective Antitumor Response by Enhancing CD8+ Immunity In Vivo

Weng, T. Y., Li, C. J., Li, C. Y., Hung, Y. H., Yen, M. C., Chang, Y. W., Chen, Y. H., Chen, Y. L., Hsu, H. P., Chang, J. Y. & Lai, M. D., 2017 Dec, In : Molecular Therapy - Nucleic Acids. 9, p. 419-427 9 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Tumour cell-derived WNT5B modulates in vitro lymphangiogenesis via induction of partial endothelial-mesenchymal transition of lymphatic endothelial cells

Wang, S. H., Chang, J. S., Hsiao, J. R., Yen, Y. C., Jiang, S. S., Liu, S. H., Chen, Y. L., Shen, Y. Y., Chang, J. Y. & Chen, Y. W., 2017 Mar 1, In : Oncogene. 36, 11, p. 1503-1515 13 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)
2016

2-Aroylquinoline-5,8-diones as potent anticancer agents displaying tubulin and heat shock protein 90 (HSP90) inhibition

Nepali, K., Kumar, S., Huang, H. L., Kuo, F. C., Lee, C. H., Kuo, C. C., Yeh, T. K., Li, Y. H., Chang, J. Y., Liou, J. P. & Lee, H. Y., 2016 Jan 1, In : Organic and Biomolecular Chemistry. 14, 2, p. 716-723 8 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

A comprehensive analysis on the association between tobacco-free betel quid and risk of head and neck cancer in Taiwanese men

Wu, Y. H., Yen, C. J., Hsiao, J. R., Ou, C. Y., Huang, J. S., Wong, T. Y., Tsai, S. T., Huang, C. C., Lee, W. T., Chen, K. C., Fang, S. Y., Wu, J. L., Hsueh, W. T., Lin, F. C., Yang, M. W., Chang, J. Y., Liao, H. C., Wu, S. Y., Lin, C. L., Wang, Y. H. & 4 others, Weng, Y. L., Yang, H. C., Chen, Y. S. & Chang, J. S., 2016 Oct, In : PloS one. 11, 10, 0164937.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Allergy symptoms, serum total immunoglobulin E, and risk of head and neck cancer

Liao, H. C., Wu, S-Y., Ou, C-Y., Hsiao, J-R., Huang, J-S., Tsai, S-T., Huang, C-C., Wang, D-Y., Lee, W-T., Chen, K-C., Fang, S-Y., Wu, J-L., Huang, T-T., Wu, Y-H., Hsueh, W-T., Yen, C-J., Yang, M-W., Lin, F-C., Lai, Y-H., Chang, J-Y. & 6 others, Lin, C. L., Wang, Y. H., Weng, Y. L., Yang, H. C., Chen, Y. S. & Chang, J. S., 2016 Sep 1, In : Cancer Causes and Control. 27, 9, p. 1105-1115 11 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

A phase i clinical study of immunotherapy for advanced colorectal cancers using carcinoembryonic antigen-pulsed dendritic cells mixed with tetanus toxoid and subsequent IL-2 treatment John T Kung

Liu, K. J., Chao, T. Y., Chang, J. Y., Cheng, A. L., Ch'Ang, H. J., Kao, W. Y., Wu, Y. C., Yu, W. L., Chung, T. R. & Whang-Peng, J., 2016 Aug 24, In : Journal of biomedical science. 23, 1, 64.

Research output: Contribution to journalArticle

4 Citations (Scopus)
12 Citations (Scopus)
4 Citations (Scopus)

Development of nanoliposomal irinotecan (nal-IRI, MM-398, PEP02) in the management of metastatic pancreatic cancer

Chiang, N. J., Chang, J-Y., Shan, Y-S. & Chen, L. T., 2016 Jul 2, In : Expert Opinion on Pharmacotherapy. 17, 10, p. 1413-1420 8 p.

Research output: Contribution to journalReview article

9 Citations (Scopus)

Dysregulation of RUNX2/activin-A axis upon miR-376c downregulation promotes lymph node metastasis in head and neck squamous cell carcinoma

Chang, W. M., Lin, Y. F., Su, C. Y., Peng, H. Y., Chang, Y. C., Lai, T. C., Wu, G. H., Hsu, Y. M., Chi, L. H., Hsiao, J. R., Chen, C. L., Chang, J. Y., Shieh, Y. S., Hsiao, M. & Shiah, S. G., 2016 Dec 15, In : Cancer Research. 76, 24, p. 7140-7150 11 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

IL-8 induces miR-424-5p expression and modulates SOCS2/STAT5 signaling pathway in oral squamous cell carcinoma

Peng, H. Y., Jiang, S. S., Hsiao, J. R., Hsiao, M., Hsu, Y. M., Wu, G. H., Chang, W. M., Chang, J. Y., Jin, S. L. C. & Shiah, S. G., 2016 Jun 1, In : Molecular Oncology. 10, 6, p. 895-909 15 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Loss of GDF10/BMP3b as a prognostic marker collaborates with TGFBR3 to enhance chemotherapy resistance and epithelial-mesenchymal transition in oral squamous cell carcinoma

Cheng, C. W., Hsiao, J. R., Fan, C. C., Lo, Y. K., Tzen, C. Y., Wu, L. W., Fang, W. Y., Cheng, A. J., Chen, C. H., Chang, I. S., Jiang, S. S., Chang, J. Y. & Lee, A. Y. L., 2016 May 1, In : Molecular Carcinogenesis. 55, 5, p. 499-513 15 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

MiR-520h is crucial for DAPK2 regulation and breast cancer progression

Su, C. M., Wang, M. Y., Hong, C. C., Chen, H. A., Su, Y. H., Wu, C. H., Huang, M. T., Chang, Y. W., Jiang, S. S., Sung, S. Y., Chang, J. Y., Chen, L. T., Chen, P. S. & Su, J. L., 2016 Mar 3, In : Oncogene. 35, 9, p. 1134-1142 9 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

MPT0B098, a microtubule inhibitor, suppresses JAK2/STAT3 signaling pathway through modulation of SOCS3 stability in oral squamous cell carcinoma

Peng, H. Y., Cheng, Y. C., Hsu, Y. M., Wu, G. H., Kuo, C. C., Liou, J. P., Chang, J. Y., Jin, S. L. C. & Shiah, S. G., 2016 Jul, In : PloS one. 11, 7, e0158440.

Research output: Contribution to journalArticle

13 Citations (Scopus)

The Role of Wnt Signaling in Squamous Cell Carcinoma

Shiah, S. G., Shieh, Y. S. & Chang, J. Y., 2016 Feb 1, In : Journal of Dental Research. 95, 2, p. 129-134 6 p.

Research output: Contribution to journalReview article

26 Citations (Scopus)

Up-regulation of miR-455-5p by the TGF-β–SMAD signalling axis promotes the proliferation of oral squamous cancer cells by targeting UBE2B

Cheng, C. M., Shiah, S. G., Huang, C. C., Hsiao, J. R. & Chang, J. Y., 2016 Sep 1, In : Journal of Pathology. 240, 1, p. 38-49 12 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)

建立分析模組評估神經功能之方法

Shen, M-R., Chang, J-Y. & Sun, Y-T., 2016 Apr 1, Patent No. I548873

Research output: Patent

2015

A KRAS mutation status-stratified randomized phase II trial of gemcitabine and oxaliplatin alone or in combination with cetuximab in advanced biliary tract cancer

on behalf of the Taiwan Cooperative Oncology Group, 2015 May 1, In : Annals of Oncology. 26, 5, p. 943-949 7 p.

Research output: Contribution to journalArticle

71 Citations (Scopus)

Alcohol drinking obliterates the inverse association between serum retinol and risk of head and neck cancer

Chen, K. C., Hsueh, W. T., Ou, C. Y., Huang, C. C., Lee, W. T., Fang, S. Y., Tsai, S. T., Huang, J. S., Wong, T. Y., Wu, J. L., Yen, C. J., Wu, Y. H., Lin, F. C., Yang, M. W., Chang, J. Y., Liao, H. C., Wu, S. Y., Hsiao, J. R., Lin, C. L., Wang, Y. H. & 4 others, Weng, Y. L., Yang, H. C., Chen, Y. S. & Chang, J. S., 2015 Jul 1, In : Medicine (United States). 94, 26, e1064.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Antimitotic and antivascular activity of heteroaroyl-2-hydroxy-3,4,5-trimethoxybenzenes

Lee, H. Y., Chang, C. Y., Lai, M. J., Chuang, H. Y., Kuo, C. C., Chang, C. Y., Chang, J. Y. & Liou, J. P., 2015 Jul 23, In : Bioorganic and Medicinal Chemistry. 23, 15, p. 4230-4236 7 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)