• 5394 Citations
  • 40 h-Index
1994 …2020

Research output per year

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Research Output

  • 5394 Citations
  • 40 h-Index
  • 109 Article
  • 5 Review article
  • 2 Letter
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Article
2020

Genetic variations on 31 and 450 residues of influenza A nucleoprotein affect viral replication and translation

Hung, S. J., Hsu, Y. M., Huang, S. W., Tsai, H. P., Lee, L. Y. Y., Hurt, A. C., Barr, I. G., Shih, S. R. & Wang, J. R., 2020 Jan 6, In : Journal of biomedical science. 27, 1, 17.

Research output: Contribution to journalArticle

Open Access
2019

An integrated microfluidic system for rapid detection and multiple subtyping of influenza A viruses by using glycan-coated magnetic beads and RT-PCR

Shen, K. M., Sabbavarapu, N. M., Fu, C. Y., Jan, J. T., Wang, J. R., Hung, S. C. & Lee, G. B., 2019 Jan 1, In : Lab on a Chip. 19, 7, p. 1277-1286 10 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
Open Access

Enterovirus A71 containing codon-deoptimized VP1 and high-fidelity polymerase as next-generation vaccine candidate

Tsai, Y. H., Huang, S. W., Hsieh, W. S., Cheng, C. K., Chang, C. F., Wang, Y. F. & Wang, J. R., 2019 Jan 1, In : Journal of Virology. 93, 13, e02308-18.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2018
3 Citations (Scopus)

Development of an efficient viral aerosol collector for higher sampling flow rate

Lin, X. T., Hsu, N. Y., Wang, J. R., Chen, N. T., Su, H. J. & Lin, M. Y., 2018 Feb 1, In : Environmental Science and Pollution Research. 25, 4, p. 3884-3893 10 p.

Research output: Contribution to journalArticle

Glycan-binding preferences and genetic evolution of human seasonal influenza A (H3N2) viruses during 1999-2007 in Taiwan

Wang, Y. F., Chang, C. F., Tsai, H. P., Chi, C. Y., Su, I. J. & Wang, J. R., 2018 May, In : PloS one. 13, 5, e0196727.

Research output: Contribution to journalArticle

Hepatitis B virus surface gene pre-S2 mutant as a high-risk serum marker for hepatoma recurrence after curative hepatic resection

Yen, C., Ai, Y., Tsai, H., Chan, S., Yen, C., Cheng, K., Lee, Y., Kao, C., Wang, Y., Chen, Y., Lin, C., Liu, T., Tsai, H., Wang, J., Su, I. & Huang, W., 2018 Sep 1, In : Hepatology. 68, 3, p. 815-826

Research output: Contribution to journalArticle

Hepatitis B virus surface gene pre-S2 mutant as a high-risk serum marker for hepatoma recurrence after curative hepatic resection

Yen, C. J., Ai, Y. L., Tsai, H. W., Chan, S. H., Yen, C. S., Cheng, K. H., Lee, Y. P., Kao, C. W., Wang, Y. C., Chen, Y. L., Lin, C. H., Liu, T., Tsai, H. P., Wang, J. R., Su, I. J. & Huang, W., 2018 Sep, In : Hepatology. 68, 3, p. 815-826 12 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
7 Citations (Scopus)
2017

A selective bottleneck shapes the evolutionary mutant spectra of enterovirus A71 during viral dissemination in humans

Huang, S. W., Huang, Y. H., Tsai, H. P., Kuo, P. H., Wang, S. M., Liu, C. C. & Wang, J. R., 2017 Dec 1, In : Journal of Virology. 91, 23, e01062-17.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Epitope-associated and specificity-focused features of EV71-neutralizing antibody repertoires from plasmablasts of infected children

Huang, K. Y. A., Chen, M. F., Huang, Y. C., Shih, S. R., Chiu, C. H., Lin, J. J., Wang, J. R., Tsao, K. C. & Lin, T. Y., 2017 Dec 1, In : Nature communications. 8, 1, 762.

Research output: Contribution to journalArticle

14 Citations (Scopus)

UGGT1 enhances enterovirus 71 pathogenicity by promoting viral RNA synthesis and viral replication

Huang, P. N., Jheng, J. R., Arnold, J. J., Wang, J. R., Cameron, C. E. & Shih, S. R., 2017 May, In : PLoS pathogens. 13, 5, e1006375.

Research output: Contribution to journalArticle

6 Citations (Scopus)
2016

A multiplex dot hybridization assay for detection and differentiation of acanthamoeba and herpes keratitis

Kuo, M. T., Fang, P. C., Yu, H. J., Chao, T. L., Chien, C. C., Chen, S. H., Wang, J. R., Tseng, S. L., Lai, Y. H., Hsiao, C. C. & Chang, T. C., 2016 Apr 1, In : Investigative Ophthalmology and Visual Science. 57, 4, p. 2158-2163 6 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Changes of immunogenic profiles between a single dose and one booster influenza vaccination in hemodialysis patients-an 18-week, open-label trial

Chang, Y. T., Wang, J. R., Lin, M. T., Wu, C. J., Tsai, M. S., Wen-Chi, C. L., Shih, T. E., Kuo, T. H., Song, E. J. & Sung, J. M., 2016 Feb 12, In : Scientific reports. 6, 20725.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Comparison of two commercial automated nucleic acid extraction and integrated quantitation real-time PCR platforms for the detection of cytomegalovirus in plasma

Tsai, H. P., Tsai, Y. Y., Lin, I. T., Kuo, P. H., Chen, T. Y., Chang, K. C. & Wang, J. R., 2016 Aug, In : PloS one. 11, 8, e0160493.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Immunological and biochemical characterizations of coxsackievirus A6 and A10 viral particles

Liu, C. C., Guo, M. S., Wu, S. R., Lin, H. Y., Yang, Y. T., Liu, W. C., Chow, Y. H., Shieh, D. B., Wang, J. R. & Chong, P., 2016 May 1, In : Antiviral Research. 129, p. 58-66 9 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Molecular epidemiology and clinical manifestations of adenovirus respiratory infections in taiwanese children

Wang, Y. F., Shen, F. C., Wang, S. L., Kuo, P. H., Tsai, H. P., Liu, C. C., Wang, J. R. & Chi, C. Y., 2016 Jan 1, In : Medicine (United States). 95, 18, p. e3577

Research output: Contribution to journalArticle

7 Citations (Scopus)

Validation and Application of a Commercial Quantitative Real-Time Reverse Transcriptase-PCR Assay in Investigation of a Large Dengue Virus Outbreak in Southern Taiwan

Tsai, H. P., Tsai, Y. Y., Lin, I. T., Kuo, P. H., Chang, K. C., Chen, J. C., Ko, W. C. & Wang, J. R., 2016 Oct 12, In : PLoS neglected tropical diseases. 10, 10, e0005036.

Research output: Contribution to journalArticle

8 Citations (Scopus)
2015

Cell surface nucleolin facilitates enterovirus 71 binding and infection

Su, P. Y., Wang, Y. F., Huang, S. W., Lo, Y. C., Wang, Y. H., Wu, S. R., Shieh, D. B., Chen, S. H., Wang, J. R., Lai, M. D. & Chang, C. F., 2015 Jan 1, In : Journal of Virology. 89, 8, p. 4527-4538 12 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)

Conjunctival geographic ulcer: An overlooked sign of herpes simplex virus infection

Hung, J-H., Chu, C. Y., Lee, C. N., Hsu, C-K., Lee, Y-Y., Wang, J-R., Chang, K-C. & Huang, F-C., 2015 Mar 1, In : Journal of Clinical Virology. 64, p. 40-44 5 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

High Incidence of mammalian orthoreovirus identified by environmental surveillance in Taiwan

Lim, M. C. Y., Wang, Y. F., Huang, S. W., Yang, J. Y. & Wang, J-R., 2015 Nov 10, In : PloS one. 10, 11, e0142745.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Mapping enterovirus A71 antigenic determinants from viral evolution

Huang, S. W., Tai, C. H., Fonville, J. M., Lin, C. H., Wang, S-M., Liu, C-C., Su, I. J., Smith, D. J. & Wang, J-R., 2015 Jan 1, In : Journal of Virology. 89, 22, p. 11500-11506 7 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Norepinephrine and epinephrine enhanced the infectivity of enterovirus 71

Liao, Y. T., Wang, S. M., Wang, J. R., Yu, C. K. & Liu, C. C., 2015 Aug 7, In : PloS one. 10, 8, e0135154.

Research output: Contribution to journalArticle

10 Citations (Scopus)
4 Citations (Scopus)
2014

A cytoplasmic RNA virus generates functional viral small RNAs and regulates viral IRES activity in mammalian cells

Weng, K. F., Hung, C. T., Hsieh, P. T., Li, M. L., Chen, G. W., Kung, Y. A., Huang, P. N., Kuo, R. L., Chen, L. L., Lin, J. Y., Wang, R. Y. U. L., Chen, S. J., Tang, P., Horng, J. T., Huang, H. I., Wang, J. R., Ojcius, D. M., Brewer, G. & Shih, S. R., 2014 Nov 10, In : Nucleic acids research. 42, 20, p. 12789-12805 17 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Enterovirus 71-induced autophagy increases viral replication and pathogenesis in a suckling mouse model

Lee, Y. R., Wang, P. S., Wang, J. R. & Liu, H. S., 2014 Aug 20, In : Journal of biomedical science. 21, 1, 80.

Research output: Contribution to journalArticle

34 Citations (Scopus)

Epidemiology and seroepidemiology of human enterovirus 71 among Thai populations

Linsuwanon, P., Puenpa, J., Huang, S. W., Wang, Y. F., Mauleekoonphairoj, J., Wang, J. R. & Poovorawan, Y., 2014 Feb 18, In : Journal of biomedical science. 21, 1, 16.

Research output: Contribution to journalArticle

48 Citations (Scopus)
3 Citations (Scopus)

Long-Term immunogenicity studies of formalin-inactivated enterovirus 71 whole-Virion vaccine in macaques

Liu, C. C., Hwang, C. S., Yang, W. S., Tsai, D. C., Wu, S. H., Chou, A. H., Chow, Y. H., Wu, S. C., Wang, J. R., Chiang, J. R., Huang, C. C., Pan, C. H. & Chong, P., 2014 Sep 8, In : PloS one. 9, 9, e106756.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Mutations in the non-structural protein region contribute to intra-genotypic evolution of enterovirus 71

Huang, S. W., Cheng, H. L., Hsieh, H. Y., Chang, C. L., Tsai, H. P., Kuo, P. H., Wang, S. M., Liu, C. C., Su, I. J. & Wang, J. R., 2014 Apr 26, In : Journal of biomedical science. 21, 1, 33.

Research output: Contribution to journalArticle

15 Citations (Scopus)
2013

Antibodies against thrombin in dengue patients contain both anti-thrombotic and pro-fibrinolytic activities

Chuang, Y. C., Lin, Y. S., Liu, H. S., Wang, J. R. & Yeh, T. M., 2013 Aug 2, In : Thrombosis and Haemostasis. 110, 2, p. 358-365 8 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Formalin-inactivated EV71 vaccine candidate induced cross-neutralizing antibody against subgenotypes B1, B4, B5 and C4A in adult volunteers

Chou, A. H., Liu, C. C., Chang, J. Y., Jiang, R., Hsieh, Y. C., Tsao, A., Wu, C. L., Huang, J. L., Fung, C. P., Hsieh, S. M., Wang, Y. F., Wang, J. R., Hu, M. H., Chiang, J. R., Su, I. J. & Chong, P. C. S., 2013 Nov 21, In : PloS one. 8, 11, e79783.

Research output: Contribution to journalArticle

55 Citations (Scopus)

Genetic and Antigenic Characterization of Enterovirus 71 in Ho Chi Minh City, Vietnam, 2011

Thoa, L. P. K., Chiang, P. S., Khanh, T. H., Luo, S. T., Dan, T. N. H., Wang, Y. F., Thuong, T. C., Chung, W. Y., Hung, N. T., Wang, J. R., Nhan, L. N. T., Thinh, L. Q., Su, I. J., Dung, T. D. & Lee, M. S., 2013 Jul 29, In : PloS one. 8, 7, e69895.

Research output: Contribution to journalArticle

26 Citations (Scopus)

High-Incidence of Human Adenoviral Co-Infections in Taiwan

Wang, S. L., Chi, C. Y., Kuo, P. H., Tsai, H. P., Wang, S. M., Liu, C. C., Su, I. J. & Wang, J. R., 2013 Sep 20, In : PloS one. 8, 9, e75208.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Milrinone therapy for enterovirus 71-induced pulmonary edema and/or neurogenic shock in children: A randomized controlled trial

Chi, C. Y., Khanh, T. H., Thoa, L. P. K., Tseng, F. C., Wang, S. M., Thinh, L. Q., Lin, C. C., Wu, H. C., Wang, J. R., Hung, N. T., Thuong, T. C., Chang, C. M., Su, I. J. & Liu, C. C., 2013 Jul 1, In : Critical Care Medicine. 41, 7, p. 1754-1760 7 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)
2012

Cell surface sialylation affects binding of enterovirus 71 to rhabdomyosarcoma and neuroblastoma cells

Su, P. Y., Liu, Y. T., Chang, H. Y., Huang, S. W., Wang, Y. F., Yu, C. K., Wang, J. R. & Chang, C. F., 2012 Aug 3, In : BMC microbiology. 12, 162.

Research output: Contribution to journalArticle

30 Citations (Scopus)

Characterization of glycan binding specificities of influenza B viruses with correlation with hemagglutinin genotypes and clinical features

Wang, Y. F., Chang, C. F., Chi, C. Y., Wang, H. C., Wang, J. R. & Su, I. J., 2012 Apr 1, In : Journal of Medical Virology. 84, 4, p. 679-685 7 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Comparison of neutralizing and hemagglutination-inhibiting antibody responses for evaluating the seasonal influenza vaccine

Cheng, L. W., Huang, S. W., Huang, L. M., Chang, L. Y., Shao, P. L., Kiang, D. & Wang, J. R., 2012 Jun 1, In : Journal of Virological Methods. 182, 1-2, p. 43-49 7 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Enterovirus 71 blocks selectively type I interferon production through the 3C viral protein in mice

Lee, Y. P., Wang, Y. F., Wang, J. R., Huang, S. W. & Yu, C. K., 2012 Nov 1, In : Journal of Medical Virology. 84, 11, p. 1779-1789 11 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Immunological and Biochemical Characterization of Coxsackie Virus A16 Viral Particles

Chong, P., Guo, M. S., Lin, F. H. Y., Hsiao, K. N., Weng, S. Y., Chou, A. H., Wang, J-R., Hsieh, S. Y., Su, I. J. & Liu, C. C., 2012 Nov 30, In : PloS one. 7, 11, e49973.

Research output: Contribution to journalArticle

42 Citations (Scopus)

Immunological Evaluation and Comparison of Different EV71 Vaccine Candidates

Chou, A. H., Liu, C. C., Chang, J. Y., Lien, S. P., Guo, M. S., Tasi, H. P., Hsiao, K. N., Liu, S. J., Sia, C., Wu, S. C., Lee, M. S., Hsiao, C. H., Wang, J. R., Chow, Y. H. & Chong, P., 2012 Oct 17, In : Clinical and Developmental Immunology. 2012, 831282.

Research output: Contribution to journalArticle

30 Citations (Scopus)

Mutations in VP2 and VP1 capsid proteins increase infectivity and mouse lethality of enterovirus 71 by virus binding and RNA accumulation enhancement

Huang, S. W., Wang, Y. F., Yu, C. K., Su, I. J. & Wang, J. R., 2012 Jan 5, In : Virology. 422, 1, p. 132-143 12 p.

Research output: Contribution to journalArticle

59 Citations (Scopus)

Poor immune response to a standard single dose non-adjuvanted vaccination against 2009 pandemic H1N1 influenza virus A in the adult and elder hemodialysis patients

Chang, Y. T., Guo, C. Y., Tsai, M. S., Cheng, Y. Y., Lin, M. T., Chen, C. H., Shen, D., Wang, J. R. & Sung, J. M., 2012 Jul 13, In : Vaccine. 30, 33, p. 5009-5018 10 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Receptor binding surveillance of influenza clinical isolates

Wang, Y. F., Lao, W. I., Kuo, Y. D., Guu, S. Y., Wang, H. C., Lin, C. H., Wang, J. R., Su, I. J. & Chang, C. F., 2012 Jun 1, In : Future Virology. 7, 6, p. 621-633 13 p.

Research output: Contribution to journalArticle

Reemerging of enterovirus 71 in Taiwan: The age impact on disease severity

Wang, S. M., Ho, T. S., Lin, H. C., Lei, H. Y., Wang, J. R. & Liu, C. C., 2012 Jun 1, In : European Journal of Clinical Microbiology and Infectious Diseases. 31, 6, p. 1219-1224 6 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

The regulatory T cells in anti-influenza antibody response post influenza vaccination

Wang, S. M., Tsai, M. H., Lei, H. Y., Wang, J. R. & Liu, C. C., 2012 Sep 1, In : Human Vaccines and Immunotherapeutics. 8, 9, p. 1243-1249 7 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)
2011

An echovirus 18-associated outbreak of aseptic meningitis in Taiwan: Epidemiology and diagnostic and genetic aspects

Tsai, H. P., Huang, S. W., Wu, F. L., Kuo, P. H., Wang, S. M., Liu, C. C., Su, I. J. & Wang, J. R., 2011 Sep 1, In : Journal of Medical Microbiology. 60, 9, p. 1360-1365 6 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

A single nucleotide in stem loop II of 5′-untranslated region contributes to virulence of Enterovirus 71 in mice

Yeh, M. T., Wang, S. W., Yu, C. K., Lin, K. H., Lei, H. Y., Su, I. J. & Wang, J. R., 2011 Nov 1, In : PloS one. 6, 10, e27082.

Research output: Contribution to journalArticle

44 Citations (Scopus)

Echovirus 18 meningitis in southern Taiwan

Wang, S. M., Ho, T. S., Shen, C. F., Wang, J. R. & Liu, C. C., 2011 Mar, In : Pediatric Infectious Disease Journal. 30, 3, p. 259-260 2 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)