• 1462 Citations
  • 22 h-Index
1991 …2019
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Research Output 1991 2019

2019

By protecting against cutaneous inflammation, epidermal pigmentation provided an additional advantage for ancestral humans

Lin, T. K., Man, M. Q., Abuabara, K., Wakefield, J. S., Sheu, H. M., Tsai, J. C., Lee, C. H. & Elias, P. M., 2019 Dec 1, In : Evolutionary Applications. 12, 10, p. 1960-1970 11 p.

Research output: Contribution to journalArticle

Open Access
Pigmentation
pigmentation
skin
inflammation
Inflammation
4 Citations (Scopus)
Thrombomodulin
Hydrogels
Hydrogel
Hyaluronic Acid
Gelatin
2017

Effects of sebum on drug transport across the human stratum corneum

Tsai, J-C., Lan, C. C. E. & Sheu, H. M., 2017 Apr 28, Agache's Measuring the Skin: Non-invasive Investigations, Physiology, Normal Constants: Second Edition. Springer International Publishing, p. 389-395 7 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Sebum
Cornea
Pharmaceutical Preparations
3 Citations (Scopus)

Endoplasmic reticulum stress-triggered autophagy and lysosomal dysfunction contribute to the cytotoxicity of amine-modified silver nanoparticles in NIH 3T3 cells

Lee, Y-H., Fang, C. Y., Chiu, H. W., Cheng, F. Y., Tsai, J-C., Chen, C. W. & Wang, Y-J., 2017 Jul 1, In : Journal of Biomedical Nanotechnology. 13, 7, p. 778-794 17 p.

Research output: Contribution to journalArticle

NIH 3T3 Cells
Endoplasmic Reticulum Stress
Autophagy
Biological systems
Cytotoxicity
2016
42 Citations (Scopus)

Mechanisms of silver nanoparticle-induced toxicity and important role of autophagy

Mao, B. H., Tsai, J-C., Chen, C. W., Yan, S-J. & Wang, Y-J., 2016 Sep 13, In : Nanotoxicology. 10, 8, p. 1021-1040 20 p.

Research output: Contribution to journalReview article

Autophagy
Ubiquitin
Silver
Nanoparticles
Toxicity
2015

Barrier abnormalities and keratinocyte-derived cytokine cascade after cessation of long-term topical glucocorticosteroid on hairless mouse skin

Lin, T. K., Wei, K. J., Wu, C. H., Lai, F. J., Lan, C. C. E., Chang, C. H., Peng, A. C. Y., Tsai, J-C. & Sheu, H. M., 2015 Jun 1, In : Dermatologica Sinica. 33, 2, p. 103-111 9 p.

Research output: Contribution to journalArticle

Hairless Mouse
Keratinocytes
Adrenal Cortex Hormones
Cytokines
Skin
44 Citations (Scopus)

Cationic polystyrene nanospheres induce autophagic cell death through the induction of endoplasmic reticulum stress

Chiu, H. W., Xia, T., Lee, Y-H., Chen, C. W., Tsai, J-C. & Wang, Y-J., 2015 Jan 14, In : Nanoscale. 7, 2, p. 736-746 11 p.

Research output: Contribution to journalArticle

Nanospheres
Polystyrenes
Cell death
Nanoparticles
Surface charge

Corrigendum to "barrier abnormalities and keratinocyte-derived cytokine cascade after cessation of long-term topical glucocorticosteroid on hairless mouse skin" [Dermatol Sin 33 (2015) 103-111]

Lin, T. K., Wei, K. C., Wu, C. H., Lai, F. J., Lan, C. C. E., Chang, C. H., Peng, A. C. Y., Tsai, J-C. & Sheu, H. M., 2015 Dec 1, In : Dermatologica Sinica. 33, 4, 1 p.

Research output: Contribution to journalComment/debate

Hairless Mouse
Keratinocytes
Cytokines
Skin
corrigendum
3 Citations (Scopus)

Editorial

Oo, C., Tsai, J-C. & Kao, H. D., 2015 Jan 1, In : Drug Discovery Today. 20, 6, p. 645-647 3 p.

Research output: Contribution to journalEditorial

Molecular Diagnostic Techniques
Diffusion of Innovation
Predictive Value of Tests
Nanomedicine
Drug Approval
8 Citations (Scopus)

Human sebum extract induces barrier disruption and cytokine expression in murine epidermis

Guo, J. W., Lin, T. K., Wu, C. H., Wei, K. C., Lan, C. C. E., Peng, A. C. Y., Tsai, J-C. & Sheu, H. M., 2015 Apr 1, In : Journal of Dermatological Science. 78, 1, p. 34-43 10 p.

Research output: Contribution to journalArticle

Dermatitis
Sebum
Epidermis
Skin
Irritants

There is no better time than the present: Nanotechnology as a disruptive innovation for drug development

Oo, C., Tsai, J-C. & Kao, H. D., 2015 Jun 8, In : Drug Discovery Today. 20, 6, p. 645-647 3 p.

Research output: Contribution to journalArticle

Nanotechnology
Pharmaceutical Preparations
2014
174 Citations (Scopus)

Cytotoxicity, oxidative stress, apoptosis and the autophagic effects of silver nanoparticles in mouse embryonic fibroblasts

Lee, Y-H., Cheng, F. Y., Chiu, H. W., Tsai, J-C., Fang, C. Y., Chen, C. W. & Wang, Y-J., 2014 Jan 1, In : Biomaterials. 35, 16, p. 4706-4715 10 p.

Research output: Contribution to journalArticle

NIH 3T3 Cells
Oxidative stress
Autophagy
Cell death
Fibroblasts
2 Citations (Scopus)

Detection and distribution of endogenous steroids in human stratum corneum

Tseng, S. P., Lu, C-C., Liao, P-C., Chou, C-H., Sheu, H. M. & Tsai, J-C., 2014 Mar 1, In : Dermatologica Sinica. 32, 1, p. 19-24 6 p.

Research output: Contribution to journalArticle

Cortisone
Cornea
Steroids
Hydrocortisone
Forearm
3 Citations (Scopus)

Development of taiwan’s strategies for regulating nanotechnology-based pharmaceuticals harmonized with international considerations

Guo, J. W., Lee, Y-H., Huang, H. W., Tzou, M. C., Wang, Y-J. & Tsai, J-C., 2014 Oct 15, In : International journal of nanomedicine. 9, 1, p. 4773-4783 11 p.

Research output: Contribution to journalArticle

Nanotechnology
Drug products
Taiwan
Medical nanotechnology
Pharmaceutical Preparations
26 Citations (Scopus)

N-acetylcysteine attenuates hexavalent chromium-induced hypersensitivity through inhibition of cell death, ROS-related signaling and cytokine expression

Lee, Y-H., Su, S. B., Huang, C. C., Sheu, H. M., Tsai, J-C., Lin, C. H., Wang, Y-J. & Wang, B. J., 2014 Sep 23, In : PloS one. 9, 9, e108317.

Research output: Contribution to journalArticle

acetylcysteine
Acetylcysteine
Cell death
chromium
hypersensitivity
2013

Cationic polystyrene nanosphere induces autophagy through inhibition of the Akt/mTOR and activation of the AMPK signaling pathways in macrophage and epithelial cells

Chiu, H. W., Xia, T., Tsai, J-C., Chen, C. W. & Wang, Y-J., 2013 Aug 9, Technical Proceedings of the 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013. p. 385-387 3 p. (Technical Proceedings of the 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013; vol. 3).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Nanospheres
AMP-Activated Protein Kinases
Polystyrenes
Autophagy
Epithelial Cells
4 Citations (Scopus)

Lauroyl/Palmitoyl glycol chitosan gels enhance skin delivery of magnesium ascorbyl phosphate

Wang, P. C., Huang, Y. L., Hou, S-S., Chou, C-H. & Tsai, J-C., 2013 Jul 1, In : Journal of Cosmetic Science. 64, 4, p. 273-286 14 p.

Research output: Contribution to journalArticle

Magnesium
Skin
Gels
Phosphates
Polymers
12 Citations (Scopus)
Epirubicin
Antisense Oligonucleotides
Multiple Drug Resistance
Liposomes
Sprague Dawley Rats
2012
10 Citations (Scopus)

Effects of sebum on drug transport across the human stratum corneum in vivo

Tsai, J-C., Lu, C-C., Lin, M. K., Guo, J. W. & Sheu, H. M., 2012 Apr 1, In : Skin Pharmacology and Physiology. 25, 3, p. 124-132 9 p.

Research output: Contribution to journalArticle

Sebum
Cornea
Cimetidine
Permeability
Forehead
2011
14 Citations (Scopus)

Painless skin electroporation as a novel way for insulin delivery

Wong, T. W., Chen, T. Y., Huang, C. C., Tsai, J. C. & Hui, S. W., 2011 Sep 1, In : Diabetes Technology and Therapeutics. 13, 9, p. 929-935 7 p.

Research output: Contribution to journalArticle

Electroporation
Insulin
Skin
Skin Temperature
Microelectrodes
2 Citations (Scopus)

Simultaneous determination of p-phenylenediamines and aminophenols in hair dye products: Interlaboratory study

Yeh, Y. C., Wu, H. J., Huang, W. S., Lin, C. C., Chen, Y. P., Tzou, M. C. & Tsai, J. C., 2011 Mar 1, In : Journal of AOAC International. 94, 2, p. 650-654 5 p.

Research output: Contribution to journalArticle

aminophenols
Hair Dyes
hair
hairs
dyes
20 Citations (Scopus)

Solanum incanum extract (SR-T100) induces human cutaneous squamous cell carcinoma apoptosis through modulating tumor necrosis factor receptor signaling pathway

Wu, C. H., Liang, C. H., Shiu, L. Y., Chang, L. C., Lin, T. S., Lan, C. C. E., Tsai, J-C., Wong, T-W., Wei, K. J., Lin, T. K., Chang, N-S. & Sheu, H. M., 2011 Aug 1, In : Journal of Dermatological Science. 63, 2, p. 83-92 10 p.

Research output: Contribution to journalArticle

Solanum
Tumor Necrosis Factor Receptors
Squamous Cell Carcinoma
Apoptosis
Skin
2010
28 Citations (Scopus)

Testosterone synthesized in cultured human SZ95 sebocytes derives mainly from dehydroepiandrosterone

Chen, W. C., Tsai, S. J., Sheu, H. M., Tsai, J. C. & Zouboulis, C. C., 2010 May 1, In : Experimental Dermatology. 19, 5, p. 470-472 3 p.

Research output: Contribution to journalLetter

Dehydroepiandrosterone
Testosterone
Androgens
Fibroblast Growth Factor 9
3-Hydroxysteroid Dehydrogenases
2009
11 Citations (Scopus)
Prostaglandin Receptors
Dinoprostone
Testosterone
Dinoprost
Prostaglandin E Receptors
5 Citations (Scopus)

Skin penetrating abilities and reservoir effects of neat DMF and DMF/water mixtures

Wang, S. M., Chang, H. Y., Tsai, J. C., Lin, W. C., Shih, T. S. & Tsai, P. J., 2009 Sep 15, In : Science of the Total Environment. 407, 19, p. 5229-5234 6 p.

Research output: Contribution to journalArticle

skin
Skin
Water
water
permeability
2007
10 Citations (Scopus)

Glycopeptide-induced neutropenia: Cross-reactivity between vancomycin and teicoplanin

Hsiao, S. H., Chang, C-M., Tsai, J-C., Lin, C. Y., Liao, L. H., Lin, W. L. & Wu, T. J., 2007 May 1, In : Annals of Pharmacotherapy. 41, 5, p. 891-894 4 p.

Research output: Contribution to journalArticle

Teicoplanin
Glycopeptides
Vancomycin
Neutropenia
Agranulocytosis
2005
4 Citations (Scopus)

Effects of topical sesame oil on oxidative stress in rats

Chiang, J. P. J., Hsu, D. Z., Tsai, J-C., Sheu, H. M. & Liu, M-Y., 2005 Jan 1, In : Alternative Therapies in Health and Medicine. 11, 6, p. 40-45 6 p.

Research output: Contribution to journalArticle

Sesame Oil
Oxidative Stress
Superoxides
Taiwan
Lipopolysaccharides
40 Citations (Scopus)

Nasopharyngeal carcinoma-susceptibility locus is localized to a 132 kb segment containing HLA-A using high-resolution microsatellite mapping

Lu, C-C., Chen, J. C., Tsai, S-T., Jin, Y. T., Tsai, J-C., Chan, S-H. & Su, I. J., 2005 Jul 10, In : International Journal of Cancer. 115, 5, p. 742-746 5 p.

Research output: Contribution to journalArticle

HLA-A Antigens
Microsatellite Repeats
Genes
HLA-A2 Antigen
Nasopharyngeal carcinoma
9 Citations (Scopus)

Novel autoregulatory function of hepatitis B virus M protein on surface gene expression

Huang, T. J., Lu, C. C., Tsai, J. C., Yao, W. J., Lu, X., Lai, M. D., Liu, H. S. & Shiau, A. L., 2005 Jul 29, In : Journal of Biological Chemistry. 280, 30, p. 27742-27754 13 p.

Research output: Contribution to journalArticle

Viruses
Hepatitis B virus
Gene expression
Membrane Proteins
Gene Expression
6 Citations (Scopus)

Topical exposure to carbon disulfide induces epidermal permeability alterations in physiological and pathological changes

Chou, T. C., Tsai, J. C., Sheu, H. M., Jen, C. J., Shih, T. S. & Chang, H. Y., 2005 Sep 15, In : Toxicology Letters. 158, 3, p. 225-236 12 p.

Research output: Contribution to journalArticle

Carbon Disulfide
Permeability
Lipids
Nude Mice
Epidermis
2004
7 Citations (Scopus)

Effect of occupational exposure to rayon manufacturing chemicals on skin barrier to evaporative water loss

Chou, T. C., Shih, T. S., Tsai, J. C., Wu, J. D., Sheu, H. M. & Chang, H. Y., 2004 Sep 1, In : Journal of Occupational Health. 46, 5, p. 410-417 8 p.

Research output: Contribution to journalArticle

Occupational Exposure
Skin
Water
Hand
Tapes
14 Citations (Scopus)

Evaluation of In Vivo Bioequivalence Methodology for Topical Clobetasol 17-Propionate Based on Pharmacodynamic Modeling Using Chinese Skin

Tsai, J-C., Cheng, C. L., Tsai, Y. F., Sheu, H. M. & Chou, C-H., 2004 Jan 1, In : Journal of Pharmaceutical Sciences. 93, 1, p. 207-217 11 p.

Research output: Contribution to journalArticle

Clobetasol
Therapeutic Equivalency
Skin
Ointments
Vasoconstriction
7 Citations (Scopus)

Feasibility of rapid quantitation of stratum corneum lipid content by Fourier transform infrared spectrometry

Tsai, J-C., Lo, Y. L., Lin, C. Y., Sheu, H. M. & Lin, J-C., 2004 Jan 1, In : Spectroscopy. 18, 3, p. 423-431 9 p.

Research output: Contribution to journalArticle

Spectrometry
Fourier transforms
Infrared radiation
Lipids
Stretching
60 Citations (Scopus)

Liposomes and disaccharides as carriers in spray-dried powder formulations of superoxide dismutase

Lo, Y. L., Tsai, J-C. & Kuo, J. H., 2004 Feb 10, In : Journal of Controlled Release. 94, 2-3, p. 259-272 14 p.

Research output: Contribution to journalArticle

Disaccharides
Liposomes
Powders
Superoxide Dismutase
1,2-Dipalmitoylphosphatidylcholine
2003
11 Citations (Scopus)

Modified Nile red staining method for improved visualization of neutral lipid depositions in stratum corneum

Sheu, H. M., Tsai, J-C., Lin, T. K., Wong, T-W. & Lee, Y-Y., 2003 Sep, In : Journal of the Formosan Medical Association. 102, 9, p. 656-660 5 p.

Research output: Contribution to journalArticle

Cornea
Staining and Labeling
Lipids
Light
Extracellular Space
33 Citations (Scopus)

Noninvasive characterization of regional variation in drug transport into human stratum corneum in vivo

Tsai, J-C., Lin, C. Y., Sheu, H. M., Lo, Y. L. & Huang, Y. H., 2003 Apr 1, In : Pharmaceutical Research. 20, 4, p. 632-638 7 p.

Research output: Contribution to journalArticle

Cimetidine
Cornea
Tapes
Skin
Pharmaceutical Preparations
44 Citations (Scopus)

Tape stripping and sodium dodecyl sulfate treatment increase the molecular weight cutoff of polyethylene glycol penetration across murine skin

Tsai, J. C., Shen, L. C., Sheu, H. M. & Lu, C. C., 2003 Aug 1, In : Archives of Dermatological Research. 295, 4, p. 169-174 6 p.

Research output: Contribution to journalArticle

Sodium Dodecyl Sulfate
Molecular Weight
Skin
Surgical Tape
Acetone
2002
4 Citations (Scopus)
Clobetasol
ointments
cream
Ointments
propionates
34 Citations (Scopus)
Aminolevulinic Acid
Skin
Photochemotherapy
ethylenediamine
Chelating Agents
39 Citations (Scopus)

The potential of metabolic interventions to enhance transdermal drug delivery

Elias, P. M., Holleran, W. M., Feingold, K. R., Tsai, J-C. & Menon, G. K., 2002 Jan 1, In : Journal of Investigative Dermatology Symposium Proceedings. 7, 1, p. 79-85 7 p.

Research output: Contribution to journalArticle

Cornea
Pharmaceutical Preparations
Hairless Mouse
Epidermis
Permeability
2001
66 Citations (Scopus)
Acetone
Permeability
Skin
Water
Caffeine
28 Citations (Scopus)

Molecular weight dependence of polyethylene glycol penetration across acetone-disrupted permeability barrier

Tsai, J-C., Hung, P. L. & Sheu, H. M., 2001 Jul 30, In : Archives of Dermatological Research. 293, 6, p. 302-307 6 p.

Research output: Contribution to journalArticle

Acetone
Permeability
Molecular Weight
Skin
Hairless Mouse
2000
1 Citation (Scopus)
Nadolol
Captopril
Furosemide
Propranolol
Powders

Stability of furosemide, nadolol and propranolol hydrochloride in extemporaneously compounded powder packets from tablets

Kao, Y-H., Lin, T. R., Huang, Y. F. & Tsai, J-C., 2000 Jan 1, In : Chinese Pharmaceutical Journal. 52, 1, p. 51-58 8 p.

Research output: Contribution to journalArticle

Nadolol
Furosemide
Propranolol
Powders
Tablets
1999
40 Citations (Scopus)

Distribution of salicylic acid in human stratum corneum following topical application in vivo: A comparison of six different formulations

Tsai, J. C., Chuang, S. A., Hsu, M. Y. & Sheu, H. M., 1999 Oct 25, In : International Journal of Pharmaceutics. 188, 2, p. 145-153 9 p.

Research output: Contribution to journalArticle

Salicylic Acid
Cornea
Ointments
Collodion
Biological Availability

Editor's choice

Sheu, H. M., Chao, S-C., Wong, T-W., Lee, Y-Y., Tsai, J-C., Tsuruta, D., Kaneda, K., Teramae, H., Ishii, M., Jumbou, O., N'Guyen, J. M., Tessier, M. H., Legoux, B., Dreno, B., Van der Rhee, H. J., Van der Spek-Keijser, L. M. T., Van Westering, R., Coebergh, J. W. W., Kawakami, T., Saito, R. & 11 others, Nishie, H., Imayama, S., Furue, M., Akagi, A., Tanaka, N., Ohnishi, Y., Fujioka, A., Kawada, A., Tajima, S., Ishibashi, A. & Wollina, U., 1999 Jan 1, In : British Journal of Dermatology. 140, 3, p. 379-380 2 p.

Research output: Contribution to journalEditorial

61 Citations (Scopus)
Cornea
Lipids
Skin
Sebum
Sebaceous Glands
1998
28 Citations (Scopus)
Hairless Mouse
Thin Layer Chromatography
Epidermis
Cornea
Permeability
1996
214 Citations (Scopus)

Barrier disruption stimulates interleukin-1α expression and release from a pre-formed pool in murine epidermis

Wood, L. C., Elias, P. M., Calhoun, C., Tsai, J-C., Grunfeld, C. & Feingold, K. R., 1996 Jan 1, In : Journal of Investigative Dermatology. 106, 3, p. 397-403 7 p.

Research output: Contribution to journalArticle

Interleukin-1
Epidermis
Skin
Dermis
Tapes
82 Citations (Scopus)

Metabolic approaches to enhance transdermal drug delivery. 1. Effect of lipid synthesis inhibitors

Tsai, J-C., Guy, R. H., Thornfeldt, C. R., Gao, W. N., Feingold, K. R. & Elias, P. M., 1996 Jan 1, In : Journal of Pharmaceutical Sciences. 85, 6, p. 643-648 6 p.

Research output: Contribution to journalArticle

Lipids
fluvastatin
Lidocaine
Pharmaceutical Preparations
Ceramides