• 1517 Citations
  • 22 h-Index
1991 …2019

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

2019

By protecting against cutaneous inflammation, epidermal pigmentation provided an additional advantage for ancestral humans

Lin, T. K., Man, M. Q., Abuabara, K., Wakefield, J. S., Sheu, H. M., Tsai, J. C., Lee, C. H. & Elias, P. M., 2019 Dec 1, In : Evolutionary Applications. 12, 10, p. 1960-1970 11 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)
6 Citations (Scopus)
2017

Effects of sebum on drug transport across the human stratum corneum

Tsai, J-C., Lan, C. C. E. & Sheu, H. M., 2017 Apr 28, Agache's Measuring the Skin: Non-invasive Investigations, Physiology, Normal Constants: Second Edition. Springer International Publishing, p. 389-395 7 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Endoplasmic reticulum stress-triggered autophagy and lysosomal dysfunction contribute to the cytotoxicity of amine-modified silver nanoparticles in NIH 3T3 cells

Lee, Y-H., Fang, C. Y., Chiu, H. W., Cheng, F. Y., Tsai, J-C., Chen, C. W. & Wang, Y-J., 2017 Jul 1, In : Journal of Biomedical Nanotechnology. 13, 7, p. 778-794 17 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
2016

Mechanisms of silver nanoparticle-induced toxicity and important role of autophagy

Mao, B. H., Tsai, J-C., Chen, C. W., Yan, S-J. & Wang, Y-J., 2016 Sep 13, In : Nanotoxicology. 10, 8, p. 1021-1040 20 p.

Research output: Contribution to journalReview article

56 Citations (Scopus)
2015

Barrier abnormalities and keratinocyte-derived cytokine cascade after cessation of long-term topical glucocorticosteroid on hairless mouse skin

Lin, T. K., Wei, K. J., Wu, C. H., Lai, F. J., Lan, C. C. E., Chang, C. H., Peng, A. C. Y., Tsai, J. C. & Sheu, H. M., 2015 Jun 1, In : Dermatologica Sinica. 33, 2, p. 103-111 9 p.

Research output: Contribution to journalArticle

Cationic polystyrene nanospheres induce autophagic cell death through the induction of endoplasmic reticulum stress

Chiu, H. W., Xia, T., Lee, Y-H., Chen, C. W., Tsai, J-C. & Wang, Y-J., 2015 Jan 14, In : Nanoscale. 7, 2, p. 736-746 11 p.

Research output: Contribution to journalArticle

47 Citations (Scopus)

Corrigendum to "barrier abnormalities and keratinocyte-derived cytokine cascade after cessation of long-term topical glucocorticosteroid on hairless mouse skin" [Dermatol Sin 33 (2015) 103-111]

Lin, T. K., Wei, K. C., Wu, C. H., Lai, F. J., Lan, C. C. E., Chang, C. H., Peng, A. C. Y., Tsai, J-C. & Sheu, H. M., 2015 Dec 1, In : Dermatologica Sinica. 33, 4, 1 p.

Research output: Contribution to journalComment/debate

Editorial

Oo, C., Tsai, J. C. & Kao, H. D., 2015 Jan 1, In : Drug Discovery Today. 20, 6, p. 645-647 3 p.

Research output: Contribution to journalEditorial

3 Citations (Scopus)

Human sebum extract induces barrier disruption and cytokine expression in murine epidermis

Guo, J. W., Lin, T. K., Wu, C. H., Wei, K. C., Lan, C. C. E., Peng, A. C. Y., Tsai, J. C. & Sheu, H. M., 2015 Apr 1, In : Journal of Dermatological Science. 78, 1, p. 34-43 10 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

There is no better time than the present: Nanotechnology as a disruptive innovation for drug development

Oo, C., Tsai, J-C. & Kao, H. D., 2015 Jun 8, In : Drug Discovery Today. 20, 6, p. 645-647 3 p.

Research output: Contribution to journalArticle

2014

Cytotoxicity, oxidative stress, apoptosis and the autophagic effects of silver nanoparticles in mouse embryonic fibroblasts

Lee, Y. H., Cheng, F. Y., Chiu, H. W., Tsai, J. C., Fang, C. Y., Chen, C. W. & Wang, Y. J., 2014 May, In : Biomaterials. 35, 16, p. 4706-4715 10 p.

Research output: Contribution to journalArticle

186 Citations (Scopus)

Detection and distribution of endogenous steroids in human stratum corneum

Tseng, S. P., Lu, C-C., Liao, P-C., Chou, C-H., Sheu, H. M. & Tsai, J-C., 2014 Mar 1, In : Dermatologica Sinica. 32, 1, p. 19-24 6 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Development of taiwan’s strategies for regulating nanotechnology-based pharmaceuticals harmonized with international considerations

Guo, J. W., Lee, Y. H., Huang, H. W., Tzou, M. C., Wang, Y. J. & Tsai, J. C., 2014 Oct 15, In : International journal of nanomedicine. 9, 1, p. 4773-4783 11 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

N-acetylcysteine attenuates hexavalent chromium-induced hypersensitivity through inhibition of cell death, ROS-related signaling and cytokine expression

Lee, Y. H., Su, S. B., Huang, C. C., Sheu, H. M., Tsai, J. C., Lin, C. H., Wang, Y. J. & Wang, B. J., 2014 Sep 23, In : PloS one. 9, 9, e108317.

Research output: Contribution to journalArticle

28 Citations (Scopus)
2013

Cationic polystyrene nanosphere induces autophagy through inhibition of the Akt/mTOR and activation of the AMPK signaling pathways in macrophage and epithelial cells

Chiu, H. W., Xia, T., Tsai, J-C., Chen, C. W. & Wang, Y-J., 2013 Aug 9, Technical Proceedings of the 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013. p. 385-387 3 p. (Technical Proceedings of the 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013; vol. 3).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Lauroyl/Palmitoyl glycol chitosan gels enhance skin delivery of magnesium ascorbyl phosphate

Wang, P. C., Huang, Y. L., Hou, S. S., Chou, C. H. & Tsai, J. C., 2013 Jul 1, In : Journal of Cosmetic Science. 64, 4, p. 273-286 14 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
12 Citations (Scopus)
2012

Effects of sebum on drug transport across the human stratum corneum in vivo

Tsai, J-C., Lu, C-C., Lin, M. K., Guo, J. W. & Sheu, H. M., 2012 Apr 1, In : Skin Pharmacology and Physiology. 25, 3, p. 124-132 9 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
2011

Painless skin electroporation as a novel way for insulin delivery

Wong, T. W., Chen, T. Y., Huang, C. C., Tsai, J. C. & Hui, S. W., 2011 Sep 1, In : Diabetes Technology and Therapeutics. 13, 9, p. 929-935 7 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Simultaneous determination of p-phenylenediamines and aminophenols in hair dye products: Interlaboratory study

Yeh, Y. C., Wu, H. J., Huang, W. S., Lin, C. C., Chen, Y. P., Tzou, M. C. & Tsai, J. C., 2011 Mar 1, In : Journal of AOAC International. 94, 2, p. 650-654 5 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Solanum incanum extract (SR-T100) induces human cutaneous squamous cell carcinoma apoptosis through modulating tumor necrosis factor receptor signaling pathway

Wu, C. H., Liang, C. H., Shiu, L. Y., Chang, L. C., Lin, T. S., Lan, C. C. E., Tsai, J. C., Wong, T. W., Wei, K. J., Lin, T. K., Chang, N. S. & Sheu, H. M., 2011 Aug 1, In : Journal of Dermatological Science. 63, 2, p. 83-92 10 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)
2010

Testosterone synthesized in cultured human SZ95 sebocytes derives mainly from dehydroepiandrosterone

Chen, W. C., Tsai, S. J., Sheu, H. M., Tsai, J. C. & Zouboulis, C. C., 2010 May 1, In : Experimental Dermatology. 19, 5, p. 470-472 3 p.

Research output: Contribution to journalLetter

29 Citations (Scopus)
2009
11 Citations (Scopus)

Skin penetrating abilities and reservoir effects of neat DMF and DMF/water mixtures

Wang, S. M., Chang, H. Y., Tsai, J. C., Lin, W. C., Shih, T. S. & Tsai, P. J., 2009 Sep 15, In : Science of the Total Environment. 407, 19, p. 5229-5234 6 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
2007

Glycopeptide-induced neutropenia: Cross-reactivity between vancomycin and teicoplanin

Hsiao, S. H., Chang, C-M., Tsai, J-C., Lin, C. Y., Liao, L. H., Lin, W. L. & Wu, T. J., 2007 May 1, In : Annals of Pharmacotherapy. 41, 5, p. 891-894 4 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
2005

Effects of topical sesame oil on oxidative stress in rats

Chiang, J. P. J., Hsu, D. Z., Tsai, J-C., Sheu, H. M. & Liu, M-Y., 2005 Jan 1, In : Alternative Therapies in Health and Medicine. 11, 6, p. 40-45 6 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Nasopharyngeal carcinoma-susceptibility locus is localized to a 132 kb segment containing HLA-A using high-resolution microsatellite mapping

Lu, C-C., Chen, J. C., Tsai, S-T., Jin, Y. T., Tsai, J-C., Chan, S-H. & Su, I. J., 2005 Jul 10, In : International Journal of Cancer. 115, 5, p. 742-746 5 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)

Novel autoregulatory function of hepatitis B virus M protein on surface gene expression

Huang, T. J., Lu, C. C., Tsai, J. C., Yao, W. J., Lu, X., Lai, M. D., Liu, H. S. & Shiau, A. L., 2005 Jul 29, In : Journal of Biological Chemistry. 280, 30, p. 27742-27754 13 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Topical exposure to carbon disulfide induces epidermal permeability alterations in physiological and pathological changes

Chou, T. C., Tsai, J. C., Sheu, H. M., Jen, C. J., Shih, T. S. & Chang, H. Y., 2005 Sep 15, In : Toxicology Letters. 158, 3, p. 225-236 12 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)
2004

Effect of occupational exposure to rayon manufacturing chemicals on skin barrier to evaporative water loss

Chou, T. C., Shih, T. S., Tsai, J. C., Wu, J. D., Sheu, H. M. & Chang, H. Y., 2004 Sep 1, In : Journal of Occupational Health. 46, 5, p. 410-417 8 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Evaluation of In Vivo Bioequivalence Methodology for Topical Clobetasol 17-Propionate Based on Pharmacodynamic Modeling Using Chinese Skin

Tsai, J. C., Cheng, C. L., Tsai, Y. F., Sheu, H. M. & Chou, C. H., 2004 Jan, In : Journal of Pharmaceutical Sciences. 93, 1, p. 207-217 11 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Feasibility of rapid quantitation of stratum corneum lipid content by Fourier transform infrared spectrometry

Tsai, J. C., Lo, Y. L., Lin, C. Y., Sheu, H. M. & Lin, J. C., 2004 Jan 1, In : Spectroscopy. 18, 3, p. 423-431 9 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Liposomes and disaccharides as carriers in spray-dried powder formulations of superoxide dismutase

Lo, Y. L., Tsai, J. C. & Kuo, J. H., 2004 Feb 10, In : Journal of Controlled Release. 94, 2-3, p. 259-272 14 p.

Research output: Contribution to journalArticle

65 Citations (Scopus)
2003

Modified Nile red staining method for improved visualization of neutral lipid depositions in stratum corneum

Sheu, H. M., Tsai, J-C., Lin, T. K., Wong, T-W. & Lee, Y-Y., 2003 Sep, In : Journal of the Formosan Medical Association. 102, 9, p. 656-660 5 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Noninvasive characterization of regional variation in drug transport into human stratum corneum in vivo

Tsai, J-C., Lin, C. Y., Sheu, H. M., Lo, Y. L. & Huang, Y. H., 2003 Apr 1, In : Pharmaceutical Research. 20, 4, p. 632-638 7 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)

Tape stripping and sodium dodecyl sulfate treatment increase the molecular weight cutoff of polyethylene glycol penetration across murine skin

Tsai, J. C., Shen, L. C., Sheu, H. M. & Lu, C. C., 2003 Aug 1, In : Archives of Dermatological Research. 295, 4, p. 169-174 6 p.

Research output: Contribution to journalArticle

44 Citations (Scopus)
2002
4 Citations (Scopus)
34 Citations (Scopus)

The potential of metabolic interventions to enhance transdermal drug delivery

Elias, P. M., Holleran, W. M., Feingold, K. R., Tsai, J. & Menon, G. K., 2002 Dec, In : Journal of Investigative Dermatology Symposium Proceedings. 7, 1, p. 79-85 7 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)
2001
67 Citations (Scopus)

Molecular weight dependence of polyethylene glycol penetration across acetone-disrupted permeability barrier

Tsai, J. C., Hung, P. L. & Sheu, H. M., 2001 Jul 30, In : Archives of Dermatological Research. 293, 6, p. 302-307 6 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)
2000
1 Citation (Scopus)

Stability of furosemide, nadolol and propranolol hydrochloride in extemporaneously compounded powder packets from tablets

Kao, Y-H., Lin, T. R., Huang, Y. F. & Tsai, J-C., 2000 Jan 1, In : Chinese Pharmaceutical Journal. 52, 1, p. 51-58 8 p.

Research output: Contribution to journalArticle

1999

Distribution of salicylic acid in human stratum corneum following topical application in vivo: A comparison of six different formulations

Tsai, J. C., Chuang, S. A., Hsu, M. Y. & Sheu, H. M., 1999 Oct 25, In : International Journal of Pharmaceutics. 188, 2, p. 145-153 9 p.

Research output: Contribution to journalArticle

41 Citations (Scopus)

Editor's choice

Sheu, H. M., Chao, S. C., Wong, T. W., Lee, J. Y. Y., Tsai, J. C., Tsuruta, D., Kaneda, K., Teramae, H., Ishii, M., Jumbou, O., N'Guyen, J. M., Tessier, M. H., Legoux, B., Dreno, B., Van der Rhee, H. J., Van der Spek-Keijser, L. M. T., Van Westering, R., Coebergh, J. W. W., Kawakami, T., Saito, R. & 11 others, Nishie, H., Imayama, S., Furue, M., Akagi, A., Tanaka, N., Ohnishi, Y., Fujioka, A., Kawada, A., Tajima, S., Ishibashi, A. & Wollina, U., 1999 Jan 1, In : British Journal of Dermatology. 140, 3, p. 379-380 2 p.

Research output: Contribution to journalEditorial

61 Citations (Scopus)
1998
28 Citations (Scopus)
1996

Barrier disruption stimulates interleukin-1α expression and release from a pre-formed pool in murine epidermis

Wood, L. C., Elias, P. M., Calhoun, C., Tsai, J. C., Grunfeld, C. & Feingold, K. R., 1996 Jan 1, In : Journal of Investigative Dermatology. 106, 3, p. 397-403 7 p.

Research output: Contribution to journalArticle

217 Citations (Scopus)

Metabolic approaches to enhance transdermal drug delivery. 1. Effect of lipid synthesis inhibitors

Tsai, J. C., Guy, R. H., Thornfeldt, C. R., Gao, W. N., Feingold, K. R. & Elias, P. M., 1996 Jun, In : Journal of Pharmaceutical Sciences. 85, 6, p. 643-648 6 p.

Research output: Contribution to journalArticle

82 Citations (Scopus)