• 1843 Citations
  • 25 h-Index
1992 …2020

Research output per year

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Research Output

  • 1843 Citations
  • 25 h-Index
  • 77 Article
  • 5 Patent
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Article
2019

Differential dynamics of hepatic protein expressions with long-term cultivated hepatitis C virus infection

Tsai, P., Lin, T. Y., Cheng, S. L., Sun, H. Y., Chen, S. F. & Young, K. C., 2019 Jan 1, In : Journal of Microbiology, Immunology and Infection.

Research output: Contribution to journalArticle

Open Access

Etifoxine, a TSPO Ligand, Worsens Hepatitis C-Related Insulin Resistance but Relieves Lipid Accumulation

Lin, Y. M., Sun, H. Y., Chiu, W. T., Su, H. C., Chien, Y. C., Chang, H. A., Chong, L. W., Chang, H. C., Young, K. C., Bai, C. H. & Tsao, C. W., 2019 Jan 1, In : BioMed research international. 2019, 3102414.

Research output: Contribution to journalArticle

Open Access

Plasma proteome plus site-specific N-glycoprofiling for hepatobiliary carcinomas

Chang, T. T., Cheng, J. H., Tsai, H. W., Young, K. C., Hsieh, S. Y. & Ho, C. H., 2019 Jul, In : Journal of Pathology: Clinical Research. 5, 3, p. 199-212 14 p.

Research output: Contribution to journalArticle

Open Access
2018

Calcitriol inhibits HCV infection via blockade of activation of PPAR and interference with endoplasmic reticulum-associated degradation

Lin, Y. M., Sun, H. Y., Chiu, W. T., Su, H. C., Chien, Y. C., Chong, L. W., Chang, H. C., Bai, C. H., Young, K. C. & Tsao, C. W., 2018 Feb, In : Viruses. 10, 2, 57.

Research output: Contribution to journalArticle

3 Citations (Scopus)
6 Citations (Scopus)

ICR suckling mouse model of Zika virus infection for disease modeling and drug validation

Wu, Y. H., Tseng, C. K., Lin, C. K., Wei, C. K., Lee, J. C. & Young, K. C., 2018 Oct 1, In : PLoS neglected tropical diseases. 12, 10, p. e0006848

Research output: Contribution to journalArticle

5 Citations (Scopus)

Role of adiponectin gene variants, adipokines and hydrometry-based percent body fat in metabolically healthy and abnormal obesity

Chang, C. S., Lu, Y. J., Chang, H. H., Hsu, S. H., Kuo, P. H., Shieh, C. C., Yao, W. J., Hsu, M. C., Young, K. C., Lin, W. Y., Huang, K. C., Wu, C. H. & Tsai, Y. S., 2018 Jan, In : Obesity Research and Clinical Practice. 12, 1, p. 49-61 13 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Viral dynamics of persistent hepatitis C virus infection in high-sensitive reporter cells resemble patient's viremia

Tsai, P., Lin, C. C., Sun, H. Y., Lee, J. C., Chang, T. T. & Young, K. C., 2018 Aug, In : Journal of Microbiology, Immunology and Infection. 51, 4, p. 446-455 10 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
2017

Celastrol inhibits hepatitis C virus replication by upregulating heme oxygenase-1 via the JNK MAPK/Nrf2 pathway in human hepatoma cells

Tseng, C. K., Hsu, S. P., Lin, C. K., Wu, Y. H., Lee, J. C. & Young, K. C., 2017 Oct, In : Antiviral Research. 146, p. 191-200 10 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Lipoprotein lipase liberates free fatty acids to inhibit HCV infection and prevent hepatic lipid accumulation

Sun, H. Y., Lin, C. C., Tsai, P. J., Tsai, W. J., Lee, J. C., Tsao, C. W., Cheng, P. N., Wu, I. C., Chiu, Y. C., Chang, T. T. & Young, K. C., 2017 Apr 1, In : Cellular Microbiology. 19, 4, e12673.

Research output: Contribution to journalArticle

5 Citations (Scopus)
2016

Characterization of thermoplastic microfiltration chip for the separation of blood plasma from human blood

Chen, P. C., Chen, C. C. & Young, K. C., 2016 Sep 1, In : Biomicrofluidics. 10, 5, 054112.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Design and characterization of a capillary-driven and parallelized microfluidic chip for distributing a liquid plug

Chen, P. C., Cheng, Y. F., Young, K. C., Hsieh, H. L. & Yang, C. L., 2016 Nov 1, In : International Journal of Precision Engineering and Manufacturing. 17, 11, p. 1547-1554 8 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Fluoxetine regulates cell growth inhibition of interferon-α

Lin, Y. M., Yu, B. C., Chiu, W. T., Sun, H. Y., Chien, Y. C., Su, H. C., Yen, S. Y., Lai, H. W., Bai, C. H., Young, K. C. & Tsao, C. W., 2016 Oct, In : International Journal of Oncology. 49, 4, p. 1746-1754 9 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Human heme oxygenase 1 is a potential host cell factor against dengue virus replication

Tseng, C. K., Lin, C. K., Wu, Y. H., Chen, Y. H., Chen, W. C., Young, K. C. & Lee, J. C., 2016 Aug 24, In : Scientific reports. 6, 32176.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Prediction of early hepatocellular carcinoma recurrence using germinal center kinase-like kinase

Ho, C. H., Chuang, H. C., Wu, I. C., Tsai, H. W., Lin, Y. J., Sun, H. Y., Young, K. C., Chiu, Y. C., Cheng, P. N., Liu, W. C., Tan, T. H. & Chang, T. T., 2016 Jan 1, In : Oncotarget. 7, 31, p. 49765-49776 12 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2014

Andrographolide exerts anti-hepatitis C virus activity by up-regulating haeme oxygenase-1 via the p38 MAPK/Nrf2 pathway in human hepatoma cells

Lee, J. C., Tseng, C. K., Young, K. C., Sun, H. Y., Wang, S. W., Chen, W. C., Lin, C. K. & Wu, Y. H., 2014 Jan 1, In : British Journal of Pharmacology. 171, 1, p. 237-252 16 p.

Research output: Contribution to journalArticle

70 Citations (Scopus)

Apolipoprotein J, a glucose-upregulated molecular chaperone, stabilizes core and NS5A to promote infectious hepatitis C virus virion production

Lin, C. C., Tsai, P., Sun, H. Y., Hsu, M. C., Lee, J. C., Wu, I. C., Tsao, C. W., Chang, T. T. & Young, K. C., 2014 Jan 1, In : Journal of Hepatology. 61, 5, p. 984-993 10 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Fluoxetine a novel anti-hepatitis C virus agent via ROS-, JNK-, and PPARβ/γ-dependent pathways

Young, K. C., Bai, C. H., Su, H. C., Tsai, P. J., Pu, C. Y., Liao, C. S., Lin, Y. M., Lai, H. W., Chong, L. W., Tsai, Y. S. & Tsao, C. W., 2014 Jan 1, In : Antiviral Research. 110, p. 158-167 10 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Rosiglitazone regulates anti-inflammation and growth inhibition via PTEN

Lin, C. F., Young, K. C., Bai, C. H., Yu, B. C., Ma, C. T., Chien, Y. C., Chiang, C. L., Liao, C. S., Lai, H. W. & Tsao, C. W., 2014, In : BioMed research international. 2014, 787924.

Research output: Contribution to journalArticle

22 Citations (Scopus)
2013

Blockade of reactive oxygen species and Akt activation is critical for anti-inflammation and growth inhibition of metformin in phosphatase and tensin homolog-deficient RAW264.7 cells

Lin, C. F., Young, K. C., Bai, C. H., Yu, B. C., Ma, C. T., Chien, Y. C., Su, H. C., Wang, H. Y., Liao, C. S., Lai, H. W. & Tsao, C. W., 2013 Dec 1, In : Immunopharmacology and Immunotoxicology. 35, 6, p. 669-677 9 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Central obesity in males affected by a dyslipidemia-associated genetic polymorphism on APOA1/C3/A4/A5 gene cluster

Hsu, M. C., Chang, C. S., Lee, K. T., Sun, H. Y., Tsai, Y. S., Kuo, P. H., Young, K. C. & Wu, C. H., 2013 Mar 1, In : Nutrition and Diabetes. 3, MARCH, e61.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Design and evaluation of a portable optical-based biosensor for testing whole blood prothrombin time

Yang, C. L., Huang, S. J., Chou, C. W., Chiou, Y. C., Lin, K. P., Tsai, M. S. & Young, K. C., 2013 Jan 1, In : Talanta. 116, p. 704-711 8 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Miniaturized real-time oxygen detection systems integrated with optical fiber by doping ru-based fluorescence sensors

Fang, H. M., Huang, S. J., Yang, C. L., Young, K. C. & Yu, C. K., 2013 Mar 19, In : Journal of Medical and Biological Engineering. 33, 1, p. 117-124 8 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Point-of-care testing of portable blood coagulation detectors using optical sensors

Yang, C-L., Chiou, Y. C., Chou, C. W., Young, K-C., Huang, S. J. & Liu, C. Y., 2013 Sep 17, In : Journal of Medical and Biological Engineering. 33, 3, p. 319-324 6 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

The dyslipidemia-associated SNP on the APOA1/C3/A5 gene cluster predicts post-surgery poor outcome in Taiwanese breast cancer patients: A 10-year follow-up study

Hsu, M. C., Lee, K-T., Hsiao, W. C., Wu, C-H., Sun, H. Y., Lin, I. L. & Young, K-C., 2013 Jul 5, In : BMC cancer. 13, 330.

Research output: Contribution to journalArticle

14 Citations (Scopus)
26 Citations (Scopus)
2012

Expression of T-cell lymphoma invasion and metastasis 2 (TIAM2) promotes proliferation and invasion of liver cancer

Chen, J. S., Su, I. J., Leu, Y. W., Young, K-C. & Sun, H-F., 2012 Mar 15, In : International Journal of Cancer. 130, 6, p. 1302-1313 12 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Glycogen synthase kinase-3β is critical for Interferon-α-induced serotonin uptake in human Jurkat T cells

Tsao, C. W., Lin, C. F., Wu, H. T., Ma, C. T., Huang, W. C., Hsieh, C. Y., Choi, P. C. & Young, K-C., 2012 Jun 1, In : Journal of Cellular Physiology. 227, 6, p. 2556-2566 11 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Glycogen synthase kinase-3β regulates anti-inflammatory property of fluoxetine

Su, H. C., Ma, C. T., Yu, B. C., Chien, Y. C., Tsai, C. C., Huang, W. C., Lin, C. F., Chuang, Y. H., Young, K-C., Wang, J-N. & Tsao, C. W., 2012 Oct 1, In : International Immunopharmacology. 14, 2, p. 150-156 7 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)
2011

ACSL3 and GSK-3β are essential for lipid upregulation induced by endoplasmic reticulum stress in liver cells

Chang, Y. S., Tsai, C. T., Huangfu, C. A., Huang, W. Y., Lei, H. Y., Lin, C. F., Su, I. J., Chang, W. T., Wu, P. H., Chen, Y. T., Hung, J. H., Young, K. C. & Lai, M. D., 2011 Mar 1, In : Journal of Cellular Biochemistry. 112, 3, p. 881-893 13 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)
38 Citations (Scopus)

Identification of hnRNPH1, NF45, and C14orf166 as novel host interacting partners of the mature hepatitis C virus core protein

Lee, J. W., Liao, P. C., Young, K. C., Chang, C. L., Chen, S. S. L., Chang, T. T., Lai, M. D. & Wang, S. W., 2011 Oct 7, In : Journal of Proteome Research. 10, 10, p. 4522-4534 13 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

Novel nucleotide and amino acid covariation between the 5′UTR and the NS2/NS3 proteins of hepatitis C virus: Bioinformatic and functional analyses

Sun, H. Y., Ou, N. Y., Wang, S. W., Liu, W. C., Cheng, T. F., Shr, S. J., Sun, K. T., Chang, T. T. & Young, K. C., 2011 Sep 28, In : PloS one. 6, 9, e25530.

Research output: Contribution to journalArticle

5 Citations (Scopus)
2010

Comparative proteomic profiling of plasma very-low-density and low-density lipoproteins

Sun, H. Y., Chen, S. F., Lai, M. D., Chang, T. T., Chen, T. L., Li, P. Y., Shieh, D. B. & Young, K. C., 2010 Mar 2, In : Clinica Chimica Acta. 411, 5-6, p. 336-344 9 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)
2009

A pre-S gene chip to detect pre-S deletions in hepatitis B virus large surface antigen as a predictive marker for hepatoma risk in chronic hepatitis B virus carriers

Shen, F. C., Su, I. J., Wu, H. C., Hsieh, Y. H., Yao, W. J., Young, K. C., Chang, T. C., Hsieh, H. C., Tsai, H. N. & Huang, W., 2009 Oct 12, In : Journal of biomedical science. 16, 1, 84.

Research output: Contribution to journalArticle

18 Citations (Scopus)
2008

Genotyping of hepatitis B virus - Genotypes a to G by multiplex polymerase chain reaction

Liu, W. C., Lindh, M., Buti, M., Phiet, P. H., Mizokami, M., Li, H. H., Sun, K. T., Young, K. C., Cheng, P. N., Wu, I. C. & Chang, T. T., 2008 Nov 1, In : Intervirology. 51, 4, p. 247-252 6 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)
7 Citations (Scopus)
2007
9 Citations (Scopus)
5 Citations (Scopus)

Five subgenotypes of hepatitis B virus genotype B with distinct geographic and virological characteristics

Liu, W. C., Phiet, P. H., Chiang, T. Y., Sun, K. T., Hung, K. H., Young, K. C., Wu, I. C., Cheng, P. N. & Chang, T. T., 2007 Nov 1, In : Virus Research. 129, 2, p. 212-223 12 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Seroprevalence of hepatitis E virus infection among institutionalized psychiatric patients in Taiwan

Cheng, P-N., Wang, R-H., Wu, I-C., Wu, J. C., Tseng, K. C., Young, K-C. & Chang, T-T., 2007 Jan 1, In : Journal of Clinical Virology. 38, 1, p. 44-48 5 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
2006

Quantitative profile of estrogen receptor variants/isoforms in Taiwanese women with breast cancer

Hsiao, W. C., Cho, W. C., Lin, P. W., Lin, S. L., Lee, W. Y. & Young, K. C., 2006 Jun 1, In : European Journal of Surgical Oncology. 32, 5, p. 492-497 6 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Simultaneous quantification and genotyping of hepatitis B virus for genotypes A to G by real-time PCR and two-step melting curve analysis

Liu, W. C., Mizokami, M., Buti, M., Lindh, M., Young, K. C., Sun, K. T., Chi, Y. C., Li, H. H. & Chang, T. T., 2006 Dec 1, In : Journal of Clinical Microbiology. 44, 12, p. 4491-4497 7 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)
2004
3 Citations (Scopus)

Estrogen receptor-α polymorphism in a Taiwanese clinical breast cancer population: A case-control study

Hsiao, W. C., Young, K. C., Lin, S. L. & Lin, P. W., 2004 Feb 26, In : Breast Cancer Research. 6, 3, R180.

Research output: Contribution to journalArticle

36 Citations (Scopus)

Interspousal transmission of hepatitis C virus: Application of comparing the variability of HVR1 nucleotide region

Lai, K. W., Young, K. C., Cheng, P. N., Chen, S. H. & Chang, T. T., 2004 May 1, In : Hepato-Gastroenterology. 51, 57, p. 791-795 5 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

The mRNA profile of genes in betel quid chewing oral cancer patients

Tsai, W. C., Tsai, S. T., Ko, J. Y., Jin, Y. T., Li, C., Huang, W., Young, K. C., Lai, M. D., Liu, H. S. & Wu, L. W., 2004 Apr, In : Oral Oncology. 40, 4, p. 418-426 9 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)
2003

High-dose interferon-α2b plus ribavirin combination therapy for GB virus-C/hepatitis G virus infection - A study in patients with chronic hepatitis C

Cheng, P-N., Jen, C. M., Young, K-C., Chen, C. Y., Lu, S. N., Wang, C. S. & Chang, T-T., 2003 Mar 1, In : Hepato-Gastroenterology. 50, 50, p. 449-452 4 p.

Research output: Contribution to journalArticle

Identification of a ribavirin-resistant NS5B mutation of hepatitis C virus during ribavirin monotherapy

Young, K. C., Lindsay, K. L., Lee, K. J., Liu, W. C., He, J. W., Milstein, S. L. & Lai, M. M. C., 2003 Oct 1, In : Hepatology. 38, 4, p. 869-878 10 p.

Research output: Contribution to journalArticle

144 Citations (Scopus)

Immune response to hepatitis B vaccine of subjects with isolated antibody to hepatitis B core antigen

Tseng, K. C., Lei, H. Y., Cheng, P-N., Young, K-C., Jen, C. M., Wu, C. H. & Chang, T-T., 2003 Sep 1, In : Hepato-Gastroenterology. 50, 53, p. 1474-1477 4 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)