• 1136 Citations
  • 19 h-Index
20002020

Research output per year

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Research Output

  • 1136 Citations
  • 19 h-Index
  • 34 Article
  • 1 Comment/debate
  • 1 Short survey
  • 1 Review article
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Article
2020

Wwox deficiency leads to neurodevelopmental and degenerative neuropathies and glycogen synthase kinase 3β-mediated epileptic seizure activity in mice

Cheng, Y. Y., Chou, Y. T., Lai, F. J., Jan, M. S., Chang, T. H., Jou, I. M., Chen, P. S., Lo, J. Y., Huang, S. S., Chang, N. S., Liou, Y. T., Hsu, P. C., Cheng, H. C., Lin, Y. S. & Hsu, L. J., 2020 Jan 30, In : Acta Neuropathologica Communications. 8, 1, 6.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)
2019

Strategies by which WWOX-deficient metastatic cancer cells utilize to survive via dodging, compromising, and causing damage to WWOX-positive normal microenvironment

Chou, P. Y., Lai, F. J., Chen, Y. A., Sie, Y. D., Kuo, H. L., Su, W. P., Wu, C. Y., Liu, T. Y., Wen, K. Y., Hsu, L. J., Sze, C. I. & Chang, N. S., 2019 Dec 1, In : Cell Death Discovery. 5, 1, 97.

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)
2017

Antitumor Activity of the Chinese Medicine JC-001 Is Mediated by Immunomodulation in a Murine Model of Hepatocellular Carcinoma

Chuang, M. H., Chang, J. T., Hsu, L. J., Jan, M. S. & Lu, F. J., 2017 Dec 1, In : Integrative Cancer Therapies. 16, 4, p. 516-525 10 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Exophagy of annexin A2 via RAB11, RAB8A and RAB27A in IFN-γ-stimulated lung epithelial cells

Chen, Y. D., Fang, Y. T., Cheng, Y. L., Lin, C. F., Hsu, L. J., Wang, S. Y., Anderson, R., Chang, C. P. & Lin, Y. S., 2017 Dec 1, In : Scientific reports. 7, 1, 5676.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Hyaluronan activates Hyal-2/WWOX/Smad4 signaling and causes bubbling cell death when the signaling complex is overexpressed

Hsu, L. J., Hong, Q., Chen, S. T., Kuo, H. L., Schultz, L., Heath, J., Lin, S. R., Lee, M. H., Li, D. Z., Li, Z. L., Cheng, H. C., Armand, G. & Chang, N. S., 2017, In : Oncotarget. 8, 12, p. 19137-19155 19 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

S100A10 Regulates ULK1 Localization to ER–Mitochondria Contact Sites in IFN-γ-Triggered Autophagy

Chen, Y. D., Fang, Y. T., Chang, C. P., Lin, C. F., Hsu, L. J., Wu, S. R., Chiu, Y. C., Anderson, R. & Lin, Y. S., 2017 Jan 6, In : Journal of Molecular Biology. 429, 1, p. 142-157 16 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2015

Regulation of cell signaling and apoptosis by tumor suppressor WWOX

Lo, J. Y., Chou, Y. T., Lai, F. J. & Hsu, L. J., 2015 Mar 25, In : Experimental Biology and Medicine. 240, 3, p. 383-391 9 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Trafficking protein particle complex 6A delta (TRAPPC6AΔ) is an extracellular plaque-forming protein in the brain

Chang, J. Y., Lee, M. H., Lin, S. R., Yang, L. Y., Sunny Sun, H., Sze, C. I., Hong, Q., Lin, Y. S., Chou, Y. T., Hsu, L. J., Jan, M. S., Gong, C. X. & Chang, N. S., 2015, In : Oncotarget. 6, 6, p. 3578-3589 12 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

UV irradiation/cold shock-mediated apoptosis is switched to bubbling cell death at low temperatures

Chen, S. J., Lin, P. W., Lin, H. P., Huang, S. S., Lai, F. J., Sheu, H. M., Hsu, L. J. & Chang, N. S., 2015 Jan 1, In : Oncotarget. 6, 10, p. 8007-8018 12 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Zfra activates memory Hyal-2+ CD3- CD19- spleen cells to block cancer growth, stemness, and metastasis in vivo

Lee, M. H., Su, W. P., Wang, W. J., Lin, S. R., Lu, C. Y., Chen, Y. A., Chang, J. Y., Huang, S. S., Chou, P. Y., Ye, S. R., Chen, S. J., He, H., Liu, T. H., Chou, Y. T., Hsu, L. J., Lai, F. J., Chen, S. J., Lee, H. C., Kakhniashvili, D., Goodman, S. R. & 1 others, Chang, N. S., 2015, In : Oncotarget. 6, 6, p. 3737-3751 15 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)
2014

Autophagy facilitates antibody-enhanced dengue virus infection in human pre-basophil/mast cells

Fang, Y. T., Wan, S. W., Lu, Y. T., Yao, J. H., Lin, C. F., Hsu, L. J., Brown, M. G., Marshall, J. S., Anderson, R. & Lin, Y. S., 2014 Oct 16, In : PloS one. 9, 10, 110655.

Research output: Contribution to journalArticle

17 Citations (Scopus)
2013

CCAAT/Enhancer binding protein d in macrophages contributes to immunosuppression and inhibits phagocytosis in nasopharyngeal carcinoma

Hsiao, Y. W., Li, C. F., Chi, J. Y., Tseng, J. T., Chang, Y., Hsu, L. J., Lee, C. H., Chang, T. H., Wang, S. M., Wang, D. D. H., Cheng, H. C. & Wang, J. M., 2013 Jul 16, In : Science Signaling. 6, 284, ra59.

Research output: Contribution to journalArticle

18 Citations (Scopus)

WWOX suppresses autophagy for inducing apoptosis in methotrexate-treated human squamous cell carcinoma

Tsai, C. W., Lai, F. J., Sheu, H. M., Lin, Y. S., Chang, T. H., Jan, M. S., Chen, S. M., Hsu, P. C., Huang, T. T., Huang, T. C., Sheen, M. C., Chen, S. T., Chang, W. C., Chang, N. S. & Hsu, L. J., 2013 Sep 1, In : Cell Death and Disease. 4, 9, e792.

Research output: Contribution to journalArticle

24 Citations (Scopus)
2012

Protective role of autophagy in branched polyethylenimine (25K)- and poly(L-lysine) (30-70K)-induced cell death

Lin, C. W., Jan, M. S., Kuo, J. H. S., Hsu, L. J. & Lin, Y. S., 2012 Dec 18, In : European Journal of Pharmaceutical Sciences. 47, 5, p. 865-874 10 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)
2011

Identification of an in vivo MEK/WOX1 complex as a master switch for apoptosis in t cell leukemia

Lin, H. P., Chang, J. Y., Lin, S. R., Lee, M. H., Huang, S. S., Hsu, L. J. & Chang, N. S., 2011 May 1, In : Genes and Cancer. 2, 5, p. 550-562 13 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)
2010

TGF-β induces TIAF1 self-aggregation via type II receptor-independent signaling that leads to generation of amyloid β plaques in Alzheimer's disease

Lee, M. H., Lin, S. R., Chang, J. Y., Schultz, L., Heath, J., Hsu, L. J., Kuo, Y. M., Hong, Q., Chiang, M. F., Gong, C. X., Sze, C. I. & Chang, N. S., 2010 Dec 1, In : Cell Death and Disease. 1, 12, e110.

Research output: Contribution to journalArticle

34 Citations (Scopus)

Zfra is a small wizard in the mitochondrial apoptosis

Dudekula, S., Lee, M. H., Hsu, L. J., Chen, S. J. & Chang, N. S., 2010 Dec, In : Aging. 2, 12, p. 1023-1029 7 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)
2009

Complement C1q activates tumor suppressor WWOX to induce apoptosis in prostate cancer cells

Hong, Q., Sze, C. I., Lin, S. R., Lee, M. H., He, R. Y., Schultz, L., Chang, J. Y., Chen, S. J., Boackle, R. J., Hsu, L. J. & Chang, N. S., 2009 Jun 1, In : PloS one. 4, 6, e5755.

Research output: Contribution to journalArticle

64 Citations (Scopus)

Dramatic co-activation of WWOX/WOX1 with CREB and NF-κB in delayed loss of small dorsal root ganglion neurons upon sciatic nerve transection in rats

Li, M. Y., Lai, F. J., Hsu, L. J., Lo, C. P., Cheng, C. L., Lin, S. R., Lee, M. H., Chang, J. Y., Subhan, D., Tsai, M. S., Sze, C. I., Pugazhenthi, S., Chang, N. S. & Chen, S. T., 2009 Nov 12, In : PloS one. 4, 11, e7820.

Research output: Contribution to journalArticle

37 Citations (Scopus)

Transforming growth factor β1 signaling via interaction with cell surface hyal-2 and recruitment of WWOX/WOX1

Hsu, L. J., Schultz, L., Hong, Q., Van Moer, K., Heath, J., Li, M. Y., Lai, F. J., Lin, S. R., Lee, M. H., Lo, C. P., Lin, Y. S., Chen, S. T. & Chang, N. S., 2009 Jun 5, In : Journal of Biological Chemistry. 284, 23, p. 16049-16059 11 p.

Research output: Contribution to journalArticle

55 Citations (Scopus)
2008

MPP+-induced neuronal death in rats involves tyrosine 33 phosphorylation of WW domain-containing oxidoreductase WOX1

Lo, C. P., Hsu, L-J., Li, M. Y., Hsu, S. Y., Chuang, J-I., Tsai, M. S., Lin, S. R., Chang, N-S. & Chen, S. T., 2008 Apr 1, In : European Journal of Neuroscience. 27, 7, p. 1634-1646 13 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

Zfra is an inhibitor of Bcl-2 expression and cytochrome c release from the mitochondria

Hsu, L. J., Hong, Q., Schultz, L., Kuo, E., Lin, S. R., Lee, M. H., Lin, Y. S. & Chang, N. S., 2008 Jul 1, In : Cellular Signalling. 20, 7, p. 1303-1312 10 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)
2007

WW domain-containing oxidoreductase: a candidate tumor suppressor

Chang, N-S., Hsu, L-J., Lin, Y-S., Lai, F. J. & Sheu, H. M., 2007 Jan 1, In : Trends in Molecular Medicine. 13, 1, p. 12-22 11 p.

Research output: Contribution to journalArticle

90 Citations (Scopus)
36 Citations (Scopus)
2005

17β-estradiol upregulates and activates WOX1/WWOXv1 and WOX2/WWOXv2 in vitro: Potential role in cancerous progression of breast and prostate to a premetastatic state in vivo

Chang, N. S., Schultz, L., Hsu, L. J., Lewis, J., Su, M. & Sze, C. I., 2005 Jan 20, In : Oncogene. 24, 4, p. 714-723 10 p.

Research output: Contribution to journalArticle

67 Citations (Scopus)

Bcl-2 rescues ceramide- and etoposide-induced mitochondrial apoptosis through blockage of caspase-2 activation

Lin, C. F., Chen, C. L., Chang, W. T., Jan, M. S., Hsu, L. J., Wu, R. H., Fang, Y. T., Tang, M. J., Chang, W. C. & Lin, Y. S., 2005 Jun 24, In : Journal of Biological Chemistry. 280, 25, p. 23758-23765 8 p.

Research output: Contribution to journalArticle

48 Citations (Scopus)
10 Citations (Scopus)
45 Citations (Scopus)
90 Citations (Scopus)

WOX1 is essential for UVB irradiation-induced apoptosis and down-regulated via translational blockade in UVB-induced cutaneous squamous cell carcinoma in vivo

Lai, F. J., Cheng, C. L., Chen, S. T., Wu, C. H., Hsu, L. J., Lee, J. Y. Y., Chao, S. C., Sheen, M. C., Shen, C. L., Chang, N. S. & Sheu, H. M., 2005 Aug 15, In : Clinical Cancer Research. 11, 16, p. 5769-5777 9 p.

Research output: Contribution to journalArticle

45 Citations (Scopus)
2004

Down-regulation of WW domain-containing oxidoreductase induces Tau phosphorylation in vitro: A potential role in Alzheimer's disease

Sze, C. I., Su, M., Pugazhenthi, S., Jambal, P., Hsu, L. J., Heath, J., Schultz, L. & Chang, N. S., 2004 Jul 16, In : Journal of Biological Chemistry. 279, 29, p. 30498-30506 9 p.

Research output: Contribution to journalArticle

80 Citations (Scopus)

Sequential caspase-2 and caspase-8 activation upstream of mitochondria during ceramide- and etoposide-induced apoptosis

Lin, C. F., Chen, C. L., Chang, W. T., Jan, M. S., Hsu, L. J., Wu, R. H., Tang, M. J., Chang, W. C. & Lin, Y. S., 2004 Sep 24, In : Journal of Biological Chemistry. 279, 39, p. 40755-40761 7 p.

Research output: Contribution to journalArticle

108 Citations (Scopus)
2001
1 Citation (Scopus)
2000
3 Citations (Scopus)