• 2770 Citations
  • 31 h-Index
1990 …2020
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Research Output 1990 2019

  • 2770 Citations
  • 31 h-Index
  • 87 Article
  • 4 Review article
  • 1 Patent
2019
Open Access
Colorectal Neoplasms
Neoplasms
Therapeutics
Genome
Mutation

Lysosomal cysteine protease cathepsin S is involved in cancer cell motility by regulating store-operated Ca2+ entry

Lin, H. H., Chen, S-J., Shen, M-R., Huang, Y. T., Hsieh, H. P., Lin, S. Y., Lin, C. C., Chang, W. S. W. & Chang, J-Y., 2019 Dec 1, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1866, 12, 118517.

Research output: Contribution to journalArticle

cathepsin S
Cysteine Proteases
Cell Movement
Neoplasms
protease S
2 Citations (Scopus)

Store-Operated Ca2+ entry in tumor progression: From molecular mechanisms to clinical implications

Chen, Y. F., Lin, P-C., Yeh, Y. M., Chen, L. H. & Shen, M-R., 2019 Jul 1, In : Cancers. 11, 7, 899.

Research output: Contribution to journalReview article

Open Access
Neoplasms
Endoplasmic Reticulum
Neoplasm Metastasis
Cellular Microenvironment
Tumor Microenvironment
3 Citations (Scopus)

The distinct role of STIM1 and STIM2 in the regulation of store-operated Ca2+ entry and cellular function

Chen, Y. F., Chen, L. H. & Shen, M-R., 2019 Jun 1, In : Journal of Cellular Physiology. 234, 6, p. 8727-8739 13 p.

Research output: Contribution to journalArticle

Uterine Cervical Neoplasms
Endoplasmic Reticulum
Sensors
Microtubules
Tissue
2018

Bcl-2 regulates store-operated Ca2+ entry to modulate ER stress-induced apoptosis

Chiu, W., Chang, H., Lin, Y., Lin, Y., Chang, H., Lin, H., Huang, S., Tang, M. & Shen, M., 2018 Dec 1, In : Cell Death Discovery. 4, 1

Research output: Contribution to journalArticle

8 Citations (Scopus)

Bcl-2 regulates store-operated Ca2+ entry to modulate ER stress-induced apoptosis

Chiu, W-T., Chang, H. A., Lin, Y. H., Lin, Y. S., Chang, H. T., Lin, H. H., Huang, S. C., Tang, M-J. & Shen, M-R., 2018 Dec 1, In : Cell Death Discovery. 4, 1, 37.

Research output: Contribution to journalArticle

Open Access
Apoptosis
Tunicamycin
Thapsigargin
Mitochondria
Death Domain Receptors
2017
2 Citations (Scopus)

Differential Ca2+ mobilization and mast cell degranulation by FcεRI- and GPCR-mediated signaling

Chen, Y. C., Chang, Y. C., Chang, H. A., Lin, Y. S., Tsao, C. W., Shen, M-R. & Chiu, W-T., 2017 Nov 1, In : Cell Calcium. 67, p. 31-39 9 p.

Research output: Contribution to journalArticle

Cell Degranulation
Mast Cells
Histamine
Histamine Release
G-Protein-Coupled Receptors
5 Citations (Scopus)

Minoxidil is a potential neuroprotective drug for paclitaxel-induced peripheral neuropathy

Chen, Y. F., Chen, L. H., Yeh, Y-M., Wu, P-Y., Chen, Y. F., Chang, L. Y., Chang, J-Y. & Shen, M-R., 2017 Mar 28, In : Scientific reports. 7, 45366.

Research output: Contribution to journalArticle

Minoxidil
Neuroprotective Agents
Peripheral Nervous System Diseases
Paclitaxel
Hair
4 Citations (Scopus)

Selective serotonin reuptake inhibitor, fluoxetine, impairs E-cadherin-mediated cell adhesion and alters calcium homeostasis in pancreatic beta cells

Chang, H. Y., Chen, S. L., Shen, M. R., Kung, M. L., Chuang, L. M. & Chen, Y. W., 2017 Dec 1, In : Scientific reports. 7, 1, 3515.

Research output: Contribution to journalArticle

Fluoxetine
Serotonin Uptake Inhibitors
Insulin-Secreting Cells
Cadherins
Cell Adhesion
5 Citations (Scopus)

STIM1-dependent Ca2+ signaling regulates podosome formation to facilitate cancer cell invasion

Chen, Y-W., Chen, Y. F., Chiu, W. T., Chen, H. C. & Shen, M. R., 2017 Dec 1, In : Scientific reports. 7, 1, 11523.

Research output: Contribution to journalArticle

Neoplasms
Cell Surface Extensions
Rosette Formation
Podosomes
Extracellular Matrix
2 Citations (Scopus)
Macrophage Colony-Stimulating Factor
Colony-Stimulating Factor Receptors
Immunity
Macrophages
Genes
2016
8 Citations (Scopus)

Hepatitis B virus preS2-mutant large surface antigen activates store-operated calcium entry and promotes chromosome instability

Yen, T. T. C., Yang, A., Chiu, W-T., Li, T. N., Wang, L. H., Wu, Y. H., Wang, H. C., Chen, L., Wang, W. C., Huang, W-Y., Chang, C. W., Chang, M. D. T., Shen, M-R., Su, I. J. & Wang, L. H. C., 2016 Apr 26, In : Oncotarget. 7, 17, p. 23346-23360 15 p.

Research output: Contribution to journalArticle

Chromosomal Instability
Surface Antigens
Hepatitis B virus
Calcium
Endoplasmic Reticulum
2 Citations (Scopus)
Peripheral Nervous System
Peripheral Nerves
Action Potentials
potassium-chloride symporters
Microvilli
2 Citations (Scopus)

Mechanistic Study of Tetrahydrofuran-acetogenins In Triggering Endoplasmic Reticulum Stress Response-apotoposis in Human Nasopharyngeal Carcinoma

Juang, S. H., Chiang, C. Y., Liang, F. P., Chan, H. H., Yang, J. S., Wang, S. H., Lin, Y. C., Kuo, P. C., Shen, M. R., Thang, T. D., Nguyet, B. T. M., Kuo, S. C. & Wu, T. S., 2016 Dec 21, In : Scientific reports. 6, 39251.

Research output: Contribution to journalArticle

Acetogenins
Endoplasmic Reticulum Stress
Gene Knockdown Techniques
tetrahydrofuran
Nasopharyngeal carcinoma
6 Citations (Scopus)

Phosphorylation of E-cadherin at threonine 790 by protein kinase Cδ reduces β-catenin binding and suppresses the function of E-cadherin

Chen, C. L., Wang, S. H., Chan, P. C., Shen, M-R. & Chen, H. C., 2016 Jan 1, In : Oncotarget. 7, 24, p. 37260-37276 17 p.

Research output: Contribution to journalArticle

Catenins
Threonine
Cadherins
Protein Kinase C
Phosphorylation
5 Citations (Scopus)

Seeking new surgical predictors of mesh exposure after transvaginal mesh repair

Wu, P-Y., Chang, C. H., Shen, M-R., Chou, C-Y., Yang, Y-C. & Huang, Y-F., 2016 Oct 1, In : International Urogynecology Journal. 27, 10, p. 1547-1555 9 p.

Research output: Contribution to journalArticle

Surgical Mesh
Confidence Intervals
Hysterectomy
Hematoma
Multivariate Analysis
25 Citations (Scopus)

The STIM1-Orai1 pathway of store-operated Ca2+ entry controls the checkpoint in cell cycle G1/S transition

Chen, Y. W., Chen, Y. F., Chen, Y. T., Chiu, W. T. & Shen, M. R., 2016 Feb 26, In : Scientific reports. 26, 6, 22142.

Research output: Contribution to journalArticle

G1 Phase Cell Cycle Checkpoints
Cell Cycle
Down-Regulation
Cell Membrane Structures
Phosphorylation
20 Citations (Scopus)

The store-operated Ca2+ entry-mediated signaling is important for cancer spread

Chen, Y. F., Hsu, K-F. & Shen, M-R., 2016 Jun 1, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1863, 6, p. 1427-1435 9 p.

Research output: Contribution to journalArticle

Neoplasms
Cell Movement
Focal Adhesions
Traction
Proteins

建立分析模組評估神經功能之方法

Shen, M-R., Chang, J-Y. & Sun, Y-T., 2016 Apr 1, Patent No. I548873

Research output: Patent

2015
8 Citations (Scopus)

Integrating image-based high-content screening with mouse models identifies 5-hydroxydecanoate as a neuroprotective drug for paclitaxel-induced neuropathy

Chen, L. H., Sun, Y-T., Chen, Y. F., Lee, M. Y., Chang, L. Y., Chang, J-Y. & Shen, M-R., 2015 Oct 1, In : Molecular Cancer Therapeutics. 14, 10, p. 2206-2214 9 p.

Research output: Contribution to journalArticle

Neuroprotective Agents
Paclitaxel
Ligands
Neurons
Drug Therapy
50 Citations (Scopus)

Mechanical phenotype of cancer cells: Cell softening and loss of stiffness sensing

Lin, H. H., Lin, H. K., Lin, I. H., Chiou, Y. W., Chen, H. W., Liu, C. Y., Harn, H. I. C., Chiu, W-T., Wang, Y-G., Shen, M-R. & Tang, M-J., 2015 Jan 1, In : Oncotarget. 6, 25, p. 20946-20958 13 p.

Research output: Contribution to journalArticle

Phenotype
Caveolin 1
Neoplasms
Fibroblasts
Elasticity
17 Citations (Scopus)

Mechanosensitive store-operated calcium entry regulates the formation of cell polarity

Huang, Y. W., Chang, S. J., I-Chen Harn, H., Huang, H. T., Lin, H. H., Shen, M-R., Tang, M-J. & Chiu, W-T., 2015 Sep 1, In : Journal of Cellular Physiology. 230, 9, p. 2086-2097 12 p.

Research output: Contribution to journalArticle

Cell Polarity
Caveolin 1
Cells
Calcium
Polarization
36 Citations (Scopus)
RNA-Binding Proteins
Ovarian Neoplasms
Platinum
Carcinoma
Inosine Monophosphate
2014
6 Citations (Scopus)

SPAK mediates KCC3-enhanced cervical cancer tumorigenesis

Chiu, M. H., Liu, H-S., Wu, Y. H., Shen, M-R. & Chou, C-Y., 2014 Jan 1, In : FEBS Journal. 281, 10, p. 2353-2365 13 p.

Research output: Contribution to journalArticle

Symporters
Uterine Cervical Neoplasms
Carcinogenesis
Matrix Metalloproteinase 2
p38 Mitogen-Activated Protein Kinases
2013
16 Citations (Scopus)

Glycosylation regulates the function and membrane localization of KCC4

Weng, T. Y., Chiu, W-T., Liu, H-S., Cheng, H-C., Shen, M-R., Mount, D. B. & Chou, C-Y., 2013 May 1, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1833, 5, p. 1133-1146 14 p.

Research output: Contribution to journalArticle

Glycosylation
Membranes
Polysaccharides
Mutation
Protein Folding
31 Citations (Scopus)

Microtubule-associated histone deacetylase 6 supports the calcium store sensor STIM1 in mediating malignant cell behaviors

Chen, Y. T., Chen, Y. F., Chiu, W-T., Liu, K. Y., Liu, Y. L., Chang, J-Y., Chang, H-C. & Shen, M-R., 2013 Jul 15, In : Cancer Research. 73, 14, p. 4500-4509 10 p.

Research output: Contribution to journalArticle

Histone Deacetylases
Microtubules
Calcium
Uterine Cervical Neoplasms
Epithelial Cells
10 Citations (Scopus)
Self assembled monolayers
Stromal Cells
Functional groups
Cell Movement
Surface chemistry
105 Citations (Scopus)

Remodeling of calcium signaling in tumor progression

Chen, Y. F., Chen, Y. T., Chiu, W-T. & Shen, M-R., 2013 Apr 19, In : Journal of biomedical science. 20, 1, 23.

Research output: Contribution to journalReview article

Calcium Signaling
Tumors
Calcium
Molecules
Cell Movement
39 Citations (Scopus)

The ER Ca2+ sensor STIM1 regulates actomyosin contractility of migratory cells

Chen, Y. T., Chen, Y. F., Chiu, W-T., Wang, Y-G., Chang, H-C. & Shen, M-R., 2013 Mar 1, In : Journal of Cell Science. 126, 5, p. 1260-1267 8 p.

Research output: Contribution to journalArticle

Actomyosin
Endoplasmic Reticulum
Cell Movement
Uterine Cervical Neoplasms
Myosin Type II
2012
81 Citations (Scopus)

Epithelial-mesenchymal transition in cervical carcinoma

Lee, M. Y. & Shen, M-R., 2012 Feb 9, In : American Journal of Translational Research. 4, 1, p. 1-13 13 p.

Research output: Contribution to journalReview article

Epithelial-Mesenchymal Transition
Uterine Cervical Neoplasms
Carcinoma
Tumors
Cells
15 Citations (Scopus)

K+-Cl- cotransport mediates the bactericidal activity of neutrophils by regulating NADPH oxidase activation

Sun, Y-T., Shieh, C-C., Delpire, E. & Shen, M-R., 2012 Jul 1, In : Journal of Physiology. 590, 14, p. 3231-3243 13 p.

Research output: Contribution to journalArticle

NADP
Oxidoreductases
Neutrophils
Phagosomes
Phagocytosis
10 Citations (Scopus)

TGF-beta1 increases cell rigidity by enhancing expression of smooth muscle actin: Keloid-derived fibroblasts as a model for cellular mechanics

Lee, C. H., Hong, C. H., Chen, Y. T., Chen, Y. C. & Shen, M-R., 2012 Sep 1, In : Journal of Dermatological Science. 67, 3, p. 173-180 8 p.

Research output: Contribution to journalArticle

Transforming Growth Factor beta1
Keloid
Fibroblasts
Mechanics
Rigidity
2011
21 Citations (Scopus)

Aberrantly expressed AURKC enhances the transformation and tumourigenicity of epithelial cells

Tsou, J. H., Chang, K-C., Chang-Liao, P. Y., Yang, S. T., Lee, C-T., Chen, Y-P., Lee, Y. C., Lin, P-W., Lee, J-C., Shen, M-R., Chuang, C. K., Chang, W. C., Wang, J-M. & Hung, L-Y., 2011 Oct 1, In : Journal of Pathology. 225, 2, p. 243-254 12 p.

Research output: Contribution to journalArticle

Epithelial Cells
Neoplasms
Colorectal Neoplasms
Thyroid Neoplasms
Uterine Cervical Neoplasms
7 Citations (Scopus)

Attachment and morphology of adipose-derived stromal cells and exposure of cell-binding domains of adsorbed proteins on various self-assembled monolayers

Chieh, H. F., Su, F., Liao, J-D., Lin, S. C., Chang, C. W. & Shen, M-R., 2011 Apr 21, In : Soft Matter. 7, 8, p. 3808-3817 10 p.

Research output: Contribution to journalArticle

Self assembled monolayers
attachment
proteins
Vitronectin
cells
196 Citations (Scopus)
Uterine Cervical Neoplasms
Calcium
Growth
Neoplasms
Epidermal Growth Factor
24 Citations (Scopus)

The potassium-chloride cotransporter 2 promotes cervical cancer cell migration and invasion by an ion transport-independent mechanism

Wei, W. C., Akerman, C. J., Newey, S. E., Pan, J., Clinch, N. W. V., Jacob, Y., Shen, M. R., Wilkins, R. J. & Ellory, J. C., 2011 Nov 1, In : Journal of Physiology. 589, 22, p. 5349-5359 11 p.

Research output: Contribution to journalArticle

Ion Transport
Uterine Cervical Neoplasms
Cell Movement
Somatomedins
Biotinylation
2010
16 Citations (Scopus)

Deficiency of electroneutral K+-Cl- cotransporter 3 causes a disruption in impulse propagation along peripheral nerves

Sun, Y-T., Lin, T-S., Tzeng, S-F., Delpire, E. & Shen, M-R., 2010 Oct 1, In : GLIA. 58, 13, p. 1544-1552 9 p.

Research output: Contribution to journalArticle

Peripheral Nerves
Neural Conduction
Schwann Cells
Action Potentials
Axons
20 Citations (Scopus)

The emerging role of KCl cotransport in tumor biology

Chen, Y. F., Chou, C-Y., Clive Ellory, J. & Shen, M-R., 2010 Oct 8, In : American Journal of Translational Research. 2, 4, p. 345-355 11 p.

Research output: Contribution to journalReview article

Somatomedins
Tumors
Epidermal Growth Factor
Catenins
Neoplasms
43 Citations (Scopus)

ZBRK1 acts as a metastatic suppressor by directly regulating MMP9 in cervical cancer

Lin, L. F., Chuang, C. H., Li, C. F., Liao, C. C., Cheng, C. P., Cheng, T. L., Shen, M-R., Tseng, T-C., Chang, W., Lee, W. H. & Wang, J-M., 2010 Jan 1, In : Cancer Research. 70, 1, p. 192-201 10 p.

Research output: Contribution to journalArticle

Uterine Cervical Neoplasms
Neoplasm Metastasis
Neoplasms
Carcinoma
Matrix Metalloproteinase 9
2009
19 Citations (Scopus)
Aryl Hydrocarbon Receptor Nuclear Translocator
Hypoxia-Inducible Factor 1
Cyclooxygenase 2
Epidermal Growth Factor
Gene expression
28 Citations (Scopus)

Motor protein-dependent membrane trafficking of KCl cotransporter-4 is important for cancer cell invasion

Chen, Y. F., Chou, C-Y., Wilkins, R. J., Ellory, J. C., Mount, D. B. & Shen, M-R., 2009 Nov 15, In : Cancer Research. 69, 22, p. 8585-8593 9 p.

Research output: Contribution to journalArticle

Insulin-Like Growth Factor I
Membrane Proteins
Epidermal Growth Factor
Neoplasms
Microdissection
2008
20 Citations (Scopus)

Calcineurin-mediated dephosphorylation of c-Jun Ser-243 is required for c-Jun protein stability and cell transformation

Huang, C. C., Wang, J-M., Kikkawa, U., Mukai, H., Shen, M-R., Morita, I., Chen, B-K. & Chang, W. C., 2008 Apr 10, In : Oncogene. 27, 17, p. 2422-2429 8 p.

Research output: Contribution to journalArticle

Proto-Oncogene Proteins c-jun
jun Genes
Protein Stability
Calcineurin
Fluorescence Resonance Energy Transfer
36 Citations (Scopus)
Somatomedins
IGF Type 1 Receptor
Uterine Cervical Neoplasms
Insulin-Like Growth Factor Binding Protein 3
Recurrence
16 Citations (Scopus)

Conditionally replicating E1B-deleted adenovirus driven by the squamous cell carcinoma antigen 2 promoter for uterine cervical cancer therapy

Hsu, K. F., Wu, C. L., Huang, S. C., Hsieh, J. L., Huang, Y. S., Chen, Y. F., Shen, M. R., Chung, W. J., Chou, C. Y. & Shiau, A. L., 2008 Aug 18, In : Cancer Gene Therapy. 15, 8, p. 526-534 9 p.

Research output: Contribution to journalArticle

Adenoviridae
Uterine Cervical Neoplasms
Neoplasms
Therapeutics
SCID Mice
69 Citations (Scopus)
Sodium-Hydrogen Antiporter
Epidermal Growth Factor
Uterine Cervical Neoplasms
Up-Regulation
Cells
54 Citations (Scopus)

Epigenetic silencing of CCAAT/enhancer-binding protein δ activity by YY1/polycomb group/DNA methyltransferase complex

Ko, C. Y., Hsu, H. C., Shen, M-R., Chang, W. C. & Wang, J-M., 2008 Nov 7, In : Journal of Biological Chemistry. 283, 45, p. 30919-30932 14 p.

Research output: Contribution to journalArticle

Yin-Yang
CCAAT-Enhancer-Binding Proteins
Methyltransferases
Epigenomics
Gene expression
186 Citations (Scopus)
Epithelial-Mesenchymal Transition
Snails
Epidermal Growth Factor Receptor
Uterine Cervical Neoplasms
Up-Regulation
31 Citations (Scopus)

Eps8 decreases chemosensitivity and affects survival of cervical cancer patients

Chen, Y. J., Shen, M-R., Chen, Y. J., Maa, M. C. & Leu, T-H., 2008 Oct 15, In : Molecular Cancer Therapeutics. 7, 6, p. 1376-1385 10 p.

Research output: Contribution to journalArticle

Uterine Cervical Neoplasms
HeLa Cells
Survival
Cyclin D3
Cyclin E
7 Citations (Scopus)

Low substratum rigidity of collagen gel promotes ERK phosphorylation via lipid raft to augment cell migration

Wei, W. C., Hsu, Y. C., Chiu, W-T., Wang, C. Z., Wu, C. M., Wang, Y-G., Shen, M-R. & Tang, M-J., 2008 Mar 1, In : Journal of Cellular Biochemistry. 103, 4, p. 1111-1124 14 p.

Research output: Contribution to journalArticle

Phosphorylation
Rigidity
Cell Movement
Collagen
Gels
44 Citations (Scopus)

Mechanosensing machinery for cells under low substratum rigidity

Wei, W. C., Lin, H. H., Shen, M-R. & Tang, M-J., 2008 Dec 1, In : American Journal of Physiology - Cell Physiology. 295, 6

Research output: Contribution to journalArticle

Integrins
Cluster Analysis
Focal Adhesion Kinase 1
Collagen
Phosphorylation