Michael Warren Hughes

Assistant Professor

  • 1157 Citations
  • 13 h-Index
20012019
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Research Output 2001 2019

2019

Regeneration of rete ridges in Lanyu pig (Sus scrofa): Insights for human skin wound healing

Lin, C. H., Chiu, P. Y., Hsueh, Y-Y., Shieh, S-J., Wu, C-C., Wong, T-W., Chuong, C. M. & Hughes, M. W., 2019 Apr 1, In : Experimental Dermatology. 28, 4, p. 472-479 8 p.

Research output: Contribution to journalArticle

Sus scrofa
Proliferating Cell Nuclear Antigen
Wound Healing
Alkaline Phosphatase
Regeneration
5 Citations (Scopus)

The tension biology of wound healing

Harn, H. I. C., Ogawa, R., Hsu, C. K., Hughes, M. W., Tang, M. J. & Chuong, C. M., 2019 Apr, In : Experimental Dermatology. 28, 4, p. 464-471 8 p.

Research output: Contribution to journalReview article

Open Access
Wound Healing
Cicatrix
Skin
Keloid
Regeneration
2018
13 Citations (Scopus)

Mechanical forces in skin disorders

Hsu, C. K., Lin, H. H., Harn, H. I. C., Hughes, M. W., Tang, M. J. & Yang, C. C., 2018 Jun, In : Journal of Dermatological Science. 90, 3, p. 232-240 9 p.

Research output: Contribution to journalReview article

Skin
Skin Diseases
Wound Healing
Collagen
Epidermolysis Bullosa Simplex
4 Citations (Scopus)

Msx2 Supports Epidermal Competency during Wound-Induced Hair Follicle Neogenesis

Hughes, M. W., Jiang, T. X., Plikus, M. V., Guerrero-Juarez, C. F., Lin, C. H., Schafer, C., Maxson, R., Widelitz, R. B. & Chuong, C. M., 2018 Sep 1, In : Journal of Investigative Dermatology. 138, 9, p. 2041-2050 10 p.

Research output: Contribution to journalArticle

Mammals
Hair Follicle
Chemical activation
Binding Sites
Wounds and Injuries
2 Citations (Scopus)
Hair Follicle
Geriatrics
Hair
Wounds and Injuries
Wound Healing
2017
4 Citations (Scopus)

Higher plasma leptin is associated with higher risk of androgenetic alopecia in men

Yang, C-C., Chung, P. L., Lin, L. Y., Hughes, M. W. & Tsai, Y-S., 2017 Jun 1, In : Experimental Dermatology. 26, 6, p. 524-526 3 p.

Research output: Contribution to journalLetter

Alopecia
Leptin
Plasmas
Androgens
Logistics
2016
12 Citations (Scopus)

Assembling Composite Dermal Papilla Spheres with Adipose-derived Stem Cells to Enhance Hair Follicle Induction

Huang, C. F., Chang, Y. J., Hsueh, Y-Y., Huang, C. W., Wang, D. H., Huang, T. C., Wu, Y. T., Su, F., Hughes, M. W., Chuong, C. M. & Wu, C-C., 2016 May 23, In : Scientific reports. 6, 26436.

Research output: Contribution to journalArticle

Hair Follicle
Stem Cells
Skin
Hair
Peroxisome Proliferator-Activated Receptors
15 Citations (Scopus)

Hypertension impairs hippocampus-related adult neurogenesis, CA1 neuron dendritic arborization and long-term memory

Shih, Y. H., Tsai, S. F., Huang, S. H., Chiang, Y. T., Hughes, M. W., Wu, S. Y., Lee, C. W., Yang, T. T. & Kuo, Y. M., 2016 May 13, In : Neuroscience. 322, p. 346-357 12 p.

Research output: Contribution to journalArticle

Neuronal Plasticity
Long-Term Memory
Neurogenesis
Hippocampus
Surgical Instruments
4 Citations (Scopus)

Novel skin chamber for rat ischemic flap studies in regenerative wound repair

Hsueh, Y-Y., Wang, D. H., Huang, T. C., Chang, Y. J., Shao, W. C., Tuan, T. L., Hughes, M. W. & Wu, C-C., 2016 May 17, In : Stem Cell Research and Therapy. 7, 1, 72.

Research output: Contribution to journalArticle

Rats
Skin
Repair
Wounds and Injuries
Necrosis
2015
7 Citations (Scopus)

Emergence of differentially regulated pathways associated with the development of regional specificity in chicken skin

Chang, K. W., Huang, N. A., Liu, I. H., Wang, Y. H., Wu, P., Tseng, Y. T., Hughes, M. W., Jiang, X. X., Tsai, M. H., Chen, C. Y., Oyang, Y. J., Lin, E. C., Chuong, C. M. & Lin, S. P., 2015 Jan 23, In : BMC genomics. 16, 1, 22.

Research output: Contribution to journalArticle

Chickens
Skin
Feathers
Calcium Signaling
Chromatin Immunoprecipitation
13 Citations (Scopus)
Vibrissae
Leptin
Adipocytes
Hair Follicle
Adipose Tissue
12 Citations (Scopus)

Molecular insight and pharmacological approaches targeting mitochondrial dynamics in skeletal muscle during obesity

Jheng, H. F., Huang, S. H., Kuo, H. M., Hughes, M. W. & Tsai, Y-S., 2015 Jan 1, In : Annals of the New York Academy of Sciences. 1350, 1, p. 82-94 13 p.

Research output: Contribution to journalArticle

Mitochondrial Dynamics
Muscle
Skeletal Muscle
Obesity
Pharmacology
13 Citations (Scopus)

Non-invasive evaluation of therapeutic response in keloid scar using diffuse reflectance spectroscopy

Hsu, C-K., Tzeng, S. Y., Yang, C-C., Lee, Y-Y., Huang, L. L-H., Chen, W. R., Hughes, M. W., Chen, Y. W., Liao, Y. K. & Tseng, S-H., 2015 Jan 1, In : Biomedical Optics Express. 6, 2, p. 390-404 15 p.

Research output: Contribution to journalArticle

Keloid
scars
Cicatrix
Spectrum Analysis
reflectance
76 Citations (Scopus)

Organ-level quorum sensing directs regeneration in hair stem cell populations

Chen, C. C., Wang, L., Plikus, M. V., Jiang, T. X., Murray, P. J., Ramos, R., Guerrero-Juarez, C. F., Hughes, M. W., Lee, O. K., Shi, S., Widelitz, R. B., Lander, A. D. & Chuong, C. M., 2015 Apr 9, In : Cell. 161, 2, p. 277-290 14 p.

Research output: Contribution to journalArticle

Quorum Sensing
Stem cells
Hair
Regeneration
Skin
2014
10 Citations (Scopus)

Disrupted ectodermal organ morphogenesis in mice with a conditional histone deacetylase 1, 2 deletion in the epidermis

Hughes, M. W., Jiang, T. X., Lin, S. J., Leung, Y., Kobielak, K., Widelitz, R. B. & Chuong, C. M., 2014 Jan 1, In : Journal of Investigative Dermatology. 134, 1, p. 24-32 9 p.

Research output: Contribution to journalArticle

Histone Deacetylase 2
Histone Deacetylase 1
Morphogenesis
Epidermis
Hair

Epigenetic and environmental regulation of skin appendage regeneration

Jiang, T. X., Chen, C. C., Hughes, M. W., Chuong, C. M. & Widelitz, R., 2014 Jan 1, Stem Cells, Tissue Engineering and Regenerative Medicine. World Scientific Publishing Co., p. 163-184 22 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Industrial engineering
Environmental regulations
Epigenomics
Regeneration
Skin
2013
2 Citations (Scopus)
Dermatology
Methyltransferases
Stem cells
Aging of materials
Chemical activation

Nuclear topology, epigenetics, and keratinocyte differentiation

Hughes, M. W., Lu, W. & Chuong, C. M., 2013 Jan 1, In : Journal of Investigative Dermatology. 133, 9, p. 2130-2133 4 p.

Research output: Contribution to journalComment/debate

Keratinocytes
Epigenomics
Chromatin
Topology
Heterochromatin
42 Citations (Scopus)

Therapeutic strategy for hair regeneration: Hair cycle activation, niche environment modulation, wound-induced follicle neogenesis, and stem cell engineering

Chueh, S. C., Lin, S. J., Chen, C. C., Lei, M., Wang, L. M., Widelitz, R., Hughes, M. W., Jiang, T. X. & Chuong, C. M., 2013 Mar 1, In : Expert Opinion on Biological Therapy. 13, 3, p. 377-391 15 p.

Research output: Contribution to journalReview article

Cell engineering
Cell Engineering
Stem cells
Hair
Regeneration
2012
4 Citations (Scopus)

Lentiviral transduction of face and limb flaps: Implications for immunomodulation of vascularized composite allografts

Barone, A. A. L., Zhou, Z. Y., Hughes, M. W., Park, R., Schulman, R. M., Lee, S., Vidar, E. N., Shiba, T. L., Weber, E. L. & Cetrulo, C. L., 2012 Feb 1, In : Plastic and Reconstructive Surgery. 129, 2, p. 391-400 10 p.

Research output: Contribution to journalArticle

Composite Tissue Allografts
Immunomodulation
Transgenes
Extremities
Hand
43 Citations (Scopus)

Progressive alopecia reveals decreasing stem cell activation probability during aging of mice with epidermal deletion of DNA methyltransferase 1

Li, J., Jiang, T. X., Hughes, M. W., Wu, P., Widelitz, R. B., Fan, G. & Chuong, C. M., 2012 Jan 1, In : Journal of Investigative Dermatology. 132, 12, p. 2681-2690 10 p.

Research output: Contribution to journalArticle

Alopecia
Methyltransferases
Stem cells
Hair
Hair Follicle
2011
21 Citations (Scopus)

In search of the Golden Fleece: Unraveling principles of morphogenesis by studying the integrative biology of skin appendages

Hughes, M. W., Wu, P., Jiang, T. X., Lin, S. J., Dong, C. Y., Li, A., Hsieh, F. J., Widelitz, R. B. & Chuong, C. M., 2011 Apr 1, In : Integrative Biology. 3, 4, p. 388-407 20 p.

Research output: Contribution to journalReview article

Morphogenesis
Feathers
Skin
Stem cells
Stem Cells
2009
23 Citations (Scopus)

Accelerated closure of skin wounds in mice deficient in the homeobox gene Msx2

Yeh, J., Green, L. M., Jiang, T. X., Plikus, M., Huang, E., Chang, R. N., Hughes, M. W., Chuong, C. M. & Tuan, T. L., 2009 Sep 1, In : Wound Repair and Regeneration. 17, 5, p. 639-648 10 p.

Research output: Contribution to journalArticle

Homeobox Genes
Mental Competency
Skin
Wounds and Injuries
Keratinocytes
2005
68 Citations (Scopus)

The mutagenic potential of duodenoesophageal reflux

Theisen, J., Peters, J. H., Fein, M., Hughes, M., Hagen, J. A., Demeester, S. R., Demeester, T. R. & Laird, P. W., 2005 Jan 1, In : Annals of Surgery. 241, 1, p. 63-68 6 p.

Research output: Contribution to journalArticle

Duodenogastric Reflux
Mutation Rate
Nitrosamines
Mutation
Gastroesophageal Reflux
2004
147 Citations (Scopus)

Evo-Devo of amniote integuments and appendages

Wu, P., Hou, L., Plikus, M., Hughes, M., Scehnet, J., Suksaweang, S., Widelitz, R. B., Jiang, T. X. & Chuong, C. M., 2004 Jul 6, In : International Journal of Developmental Biology. 48, 2-3, p. 249-270 22 p.

Research output: Contribution to journalReview article

Feathers
Reptiles
Dinosaurs
Phenotype
Skin
87 Citations (Scopus)

Morphogenesis of chicken liver: Identification of localized growth zones and the role of β-catenin/Wnt in size regulation

Suksaweang, S., Lin, C. M., Jiang, T. X., Hughes, M. W., Widelitz, R. B. & Chuong, C. M., 2004 Feb 1, In : Developmental Biology. 266, 1, p. 109-122 14 p.

Research output: Contribution to journalArticle

Catenins
Morphogenesis
Chickens
Liver
Growth
2003
5 Citations (Scopus)

A Mouthful of Epithelial-Mesenchymal Interactions

Hughes, M. W. & Chuong, C. M., 2003 Dec, In : Journal of Investigative Dermatology. 121, 6, p. vii-viii

Research output: Contribution to journalEditorial

2002
73 Citations (Scopus)

Endoscopic augmentation of the cardia with a biocompatible injectable polymer (Enteryx) in a porcine model

Mason, R. J., Hughes, M. W., Lehman, G. A., Chiao, G., Deviere, J., Silverman, D. E., DeMeester, T. R. & Peters, J. H., 2002 Mar 21, In : Surgical Endoscopy and Other Interventional Techniques. 16, 3, p. 386-391 6 p.

Research output: Contribution to journalArticle

Cardia
Polymers
Swine
Injections
Pressure
11 Citations (Scopus)

IL-8-stimulated expression of urokinase-type plasminogen activator in human skin and human epidermal cells

Han, Y. P., Hughes, M. W., Nien, Y. D. & Garner, W. L., 2002 Jan 1, In : Journal of Surgical Research. 106, 2, p. 328-334 7 p.

Research output: Contribution to journalArticle

Urokinase-Type Plasminogen Activator
Interleukin-8
Skin
Keratinocytes
Cytokines
2001
308 Citations (Scopus)

TNF-α stimulates activation of pro-MMP2 in human skin through NF-κB mediated induction of MT1-MMP

Han, Y. P., Tuan, T. L., Wu, H., Hughes, M. & Garner, W. L., 2001 Feb 15, In : Journal of Cell Science. 114, 1, p. 131-139 9 p.

Research output: Contribution to journalArticle

Matrix Metalloproteinase 14
Tumor Necrosis Factor-alpha
Skin
Matrix Metalloproteinase 2
Fibroblasts
133 Citations (Scopus)

Transforming Growth Factor-β- and Tumor Necrosis Factor-α -mediated Induction and Proteolytic Activation of MMP-9 in Human Skin

Han, Y. P., Tuan, T. L., Hughes, M. W., Wu, H. & Garner, W. L., 2001 Jun 22, In : Journal of Biological Chemistry. 276, 25, p. 22341-22350 10 p.

Research output: Contribution to journalArticle

Matrix Metalloproteinase 9
Transforming Growth Factors
Skin
Tumor Necrosis Factor-alpha
Chemical activation