• 4097 Citations
  • 38 h-Index
1986 …2020
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Research Output 1986 2019

2019
2 Citations (Scopus)

Dichotomy of the function of DDR1 in cells and disease progression

Yeh, Y. C., Lin, H. H. & Tang, M-J., 2019 Nov 1, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1866, 11, 118473.

Research output: Contribution to journalReview article

Disease Progression
Cell Differentiation
Epithelial Cells
Collagen Receptors
Epithelial-Mesenchymal Transition
5 Citations (Scopus)

The tension biology of wound healing

Harn, H. I. C., Ogawa, R., Hsu, C-K., Hughes, M. W., Tang, M-J. & Chuong, C. M., 2019 Apr 1, In : Experimental Dermatology. 28, 4, p. 464-471 8 p.

Research output: Contribution to journalReview article

Open Access
Wound Healing
Cicatrix
Skin
Keloid
Regeneration

Tks5 and dynamin-2 enhance actin bundle rigidity in invadosomes to promote myoblast fusion

Chuang, M. C., Lin, S. S., Ohniwa, R. L., Lee, G. H., Su, Y. A., Chang, Y. C., Tang, M. J. & Liu, Y. W., 2019 May 1, In : Journal of Cell Biology. 218, 5, p. 1670-1685 16 p.

Research output: Contribution to journalArticle

Open Access
Dynamin II
Myoblasts
Actins
Muscle Development
Actin Cytoskeleton
2018

Bcl-2 regulates store-operated Ca2+ entry to modulate ER stress-induced apoptosis

Chiu, W., Chang, H., Lin, Y., Lin, Y., Chang, H., Lin, H., Huang, S., Tang, M. & Shen, M., 2018 Dec 1, In : Cell Death Discovery. 4, 1

Research output: Contribution to journalArticle

8 Citations (Scopus)

Bcl-2 regulates store-operated Ca2+ entry to modulate ER stress-induced apoptosis

Chiu, W-T., Chang, H. A., Lin, Y. H., Lin, Y. S., Chang, H. T., Lin, H. H., Huang, S. C., Tang, M-J. & Shen, M-R., 2018 Dec 1, In : Cell Death Discovery. 4, 1, 37.

Research output: Contribution to journalArticle

Open Access
Apoptosis
Tunicamycin
Thapsigargin
Mitochondria
Death Domain Receptors
9 Citations (Scopus)

Caveolin-1 Controls Hyperresponsiveness to Mechanical Stimuli and Fibrogenesis-Associated RUNX2 Activation in Keloid Fibroblasts

Hsu, C. K., Lin, H. H., Harn, H. I., Ogawa, R., Wang, Y. K., Ho, Y. T., Chen, W. R., Lee, Y. C., Lee, J. Y. Y., Shieh, S. J., Cheng, C. M., McGrath, J. A. & Tang, M. J., 2018 Jan, In : Journal of Investigative Dermatology. 138, 1, p. 208-218 11 p.

Research output: Contribution to journalArticle

Caveolin 1
Keloid
Fibroblasts
Chemical activation
trichostatin A

Caveolin-1 down-regulation is required for Wnt5a-Frizzled 2 signalling in Ha-RasV12-induced cell transformation

Lin, H. K., Lin, H. H., Chiou, Y. W., Wu, C. L., Chiu, W-T. & Tang, M-J., 2018 May 1, In : Journal of Cellular and Molecular Medicine. 22, 5, p. 2631-2643 13 p.

Research output: Contribution to journalArticle

Caveolin 1
Down-Regulation
Madin Darby Canine Kidney Cells
Exosomes
Conditioned Culture Medium
5 Citations (Scopus)

Coincidence Detection of Membrane Stretch and Extracellular pH by the Proton-Sensing Receptor OGR1 (GPR68)

Wei, W. C., Bianchi, F., Wang, Y-G., Tang, M-J., Ye, H. & Glitsch, M. D., 2018 Dec 3, In : Current Biology. 28, 23, p. 3815-3823.e4

Research output: Contribution to journalArticle

protons
Protons
Membranes
receptors
Acidification
12 Citations (Scopus)

Mechanical forces in skin disorders

Hsu, C. K., Lin, H. H., Harn, H. I. C., Hughes, M. W., Tang, M. J. & Yang, C. C., 2018 Jun, In : Journal of Dermatological Science. 90, 3, p. 232-240 9 p.

Research output: Contribution to journalReview article

Skin
Skin Diseases
Wound Healing
Collagen
Epidermolysis Bullosa Simplex
3 Citations (Scopus)

Time Series Integrative Analysis of RNA Sequencing and MicroRNA Expression Data Reveals Key Biologic Wound Healing Pathways in Keloid-Prone Individuals

Onoufriadis, A., Hsu, C-K., Ainali, C., Ung, C. Y., Rashidghamat, E., Yang, H. S., Huang, H. Y., Niazi, U., Tziotzios, C., Yang, J. C., Nuamah, R., Tang, M-J., Saxena, A., de Rinaldis, E. & McGrath, J. A., 2018 Dec 1, In : Journal of Investigative Dermatology. 138, 12, p. 2690-2693 4 p.

Research output: Contribution to journalArticle

Time series analysis
MicroRNAs
RNA
2017
27 Citations (Scopus)

Mechanotransduction of matrix stiffness in regulation of focal adhesion size and number: Reciprocal regulation of caveolin-1 and β1 integrin

Yeh, Y. C., Ling, J. Y., Chen, W. C., Lin, H. H. & Tang, M-J., 2017 Dec 1, In : Scientific reports. 7, 1, 15008.

Research output: Contribution to journalArticle

Caveolin 1
Focal Adhesions
Integrins
Cell Adhesion
Cluster Analysis
6 Citations (Scopus)

Vibrio vulnificus MARTX cytotoxin causes inactivation of phagocytosis-related signaling molecules in macrophages

Chen, C. L., Chien, S. C., Leu, T-H., Harn, H. I. C., Tang, M-J. & Hor, L. I., 2017 Aug 19, In : Journal of biomedical science. 24, 1, 58.

Research output: Contribution to journalArticle

Vibrio vulnificus
Macrophages
Cytotoxins
Phagocytosis
Focal Adhesion Kinase 2
2016
5 Citations (Scopus)

DDR1 promotes E-cadherin stability via inhibition of integrin-β1-Src activation-mediated E-cadherin endocytosis

Chen, H. R., Yeh, Y. C., Liu, C. Y., Wu, Y. T., Lo, F. Y., Tang, M-J. & Wang, Y-G., 2016 Nov 8, In : Scientific reports. 6, 36336.

Research output: Contribution to journalArticle

Cadherins
Endocytosis
Integrins
Clathrin
Discoidin Domain Receptor 1

Functions of DDR1 in epithelial cell differentiation

Yeh, Y. C. & Tang, M-J., 2016 Jan 1, Discoidin Domain Receptors in Health and Disease. Springer New York, p. 239-258 20 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Adherens Junctions
Cell Differentiation
Epithelial Cells
Disease Progression
Collagen Receptors
5 Citations (Scopus)

Role of Excessive Autophagy Induced by Mechanical Overload in Vein Graft Neointima Formation: Prediction and Prevention

Chang, Y. J., Huang, H. C., Hsueh, Y. Y., Wang, S. W., Su, F. C., Chang, C. H., Tang, M. J., Li, Y. S., Wang, S. H., Shung, K. K., Chien, S. & Wu, C. C., 2016 Feb 26, In : Scientific reports. 6, 22147.

Research output: Contribution to journalArticle

Neointima
Autophagy
Veins
Transplants
Ultrasonics
2 Citations (Scopus)

Spatial distribution of filament elasticity determines the migratory behaviors of a cell

Harn, H. I. C., Hsu, C-K., Wang, Y-G., Huang, Y. W., Chiu, W-T., Lin, H. H., Cheng, C. M. & Tang, M-J., 2016 Jul 3, In : Cell Adhesion and Migration. 10, 4, p. 368-377 10 p.

Research output: Contribution to journalArticle

Elasticity
Actin Cytoskeleton
Focal Adhesions
Atomic Force Microscopy
Research
2015
26 Citations (Scopus)

Albumin stimulates renal tubular inflammation through an HSP70-TLR4 axis in mice with early diabetic nephropathy

Jheng, H. F., Tsai, P-J., Chuang, Y. L., Shen, Y. T., Tai, T. A., Chen, W. C., Chou, C. K., Ho, L. C., Tang, M-J., Lai, K. T. A., Sung, J-M. & Tsai, Y-S., 2015 Oct 1, In : DMM Disease Models and Mechanisms. 8, 10, p. 1311-1321 11 p.

Research output: Contribution to journalArticle

HSP70 Heat-Shock Proteins
Diabetic Nephropathies
Albumins
Inflammation
Kidney
20 Citations (Scopus)

Matrix-Stiffness-Regulated Inverse Expression of Krüppel-Like Factor 5 and Krüppel-Like Factor 4 in the Pathogenesis of Renal Fibrosis

Chen, W. C., Lin, H. H. & Tang, M-J., 2015 Sep 1, In : American Journal of Pathology. 185, 9, p. 2468-2481 14 p.

Research output: Contribution to journalArticle

Extracellular Signal-Regulated MAP Kinases
Fibrosis
Kidney
Ureteral Obstruction
Cyclin D1
14 Citations (Scopus)

Mechanical coupling of cytoskeletal elasticity and force generation is crucial for understanding the migrating nature of keloid fibroblasts

Harn, H. I. C., Wang, Y. K., Hsu, C. K., Ho, Y. T., Huang, Y. W., Chiu, W. T., Lin, H. H., Cheng, C. M. & Tang, M. J., 2015 Aug 1, In : Experimental Dermatology. 24, 8, p. 579-584 6 p.

Research output: Contribution to journalArticle

Keloid
Elasticity
Fibroblasts
Spatial distribution
Actins
50 Citations (Scopus)

Mechanical phenotype of cancer cells: Cell softening and loss of stiffness sensing

Lin, H. H., Lin, H. K., Lin, I. H., Chiou, Y. W., Chen, H. W., Liu, C. Y., Harn, H. I. C., Chiu, W-T., Wang, Y-G., Shen, M-R. & Tang, M-J., 2015 Jan 1, In : Oncotarget. 6, 25, p. 20946-20958 13 p.

Research output: Contribution to journalArticle

Phenotype
Caveolin 1
Neoplasms
Fibroblasts
Elasticity
17 Citations (Scopus)

Mechanosensitive store-operated calcium entry regulates the formation of cell polarity

Huang, Y. W., Chang, S. J., I-Chen Harn, H., Huang, H. T., Lin, H. H., Shen, M-R., Tang, M-J. & Chiu, W-T., 2015 Sep 1, In : Journal of Cellular Physiology. 230, 9, p. 2086-2097 12 p.

Research output: Contribution to journalArticle

Cell Polarity
Caveolin 1
Cells
Calcium
Polarization
115 Citations (Scopus)

Vimentin contributes to epithelial-mesenchymal transition ancer cell mechanics by mediating cytoskeletal organization and focal adhesion maturation

Liu, C. Y., Lin, H. H., Tang, M-J. & Wang, Y-G., 2015 Jan 1, In : Oncotarget. 6, 18, p. 15966-15983 18 p.

Research output: Contribution to journalArticle

Focal Adhesions
Epithelial-Mesenchymal Transition
Vimentin
Mechanics
Cytoskeleton
9 Citations (Scopus)

β-PIX controls intracellular viscoelasticity to regulate lung cancer cell migration

Yu, H. W., Chen, Y. Q., Huang, C. M., Liu, C. Y., Chiou, A., Wang, Y-G., Tang, M-J. & Kuo, J. C., 2015 May 1, In : Journal of Cellular and Molecular Medicine. 19, 5, p. 934-947 14 p.

Research output: Contribution to journalArticle

Focal Adhesions
Cell Movement
Lung Neoplasms
Actins
Actin Cytoskeleton
2014
22 Citations (Scopus)

A nanopatterned cell-seeded cardiac patch prevents electro-uncoupling and improves the therapeutic efficacy of cardiac repair

Lin, Y. D., Ko, M. C., Wu, S. T., Li, S. F., Hu, J. F., Lai, Y. J., Harn, H. I. C., Laio, I. C., Yeh, M-L., Yeh, H. I., Tang, M-J., Chang, K-C., Su, F., Wei, E. I. H., Lee, S. T., Chen, J. H., Hoffman, A. S., Wu, W. T. & Hsieh, P. C. H., 2014 Jan 1, In : Biomaterials Science. 2, 4, p. 567-580 14 p.

Research output: Contribution to journalArticle

Endothelial cells
Repair
Anisotropy
Medical nanotechnology
Hemodynamics
11 Citations (Scopus)

Caveolin-1 alters the pattern of cytoplasmic Ca2+ oscillations and Ca2+-dependent gene expression by enhancing leukotriene receptor desensitization

Yeh, Y. C., Tang, M-J. & Parekh, A. B., 2014 Jun 20, In : Journal of Biological Chemistry. 289, 25, p. 17843-17853 11 p.

Research output: Contribution to journalArticle

Leukotriene Receptors
Caveolin 1
Gene expression
Gene Expression
Type C Phospholipases
16 Citations (Scopus)

GEF-H1 controls focal adhesion signaling that regulates mesenchymal stem cell lineage commitment

Huang, I. H., Hsiao, C. T., Wu, J. C., Shen, R. F., Liu, C. Y., Wang, Y-G., Chen, Y. C., Huang, C. M., del Álamo, J. C., Chang, Z. F., Tang, M-J., Khoo, K. H. & Kuo, J. C., 2014 Jan 1, In : Journal of Cell Science. 127, 19, p. 4186-4200 15 p.

Research output: Contribution to journalArticle

Focal Adhesions
Cell Lineage
Mesenchymal Stromal Cells
Stress Fibers
Osteogenesis
24 Citations (Scopus)
Cell Differentiation
Cell Proliferation
Epithelial Cells
Epithelial-Mesenchymal Transition
Transforming Growth Factors
12 Citations (Scopus)

SCP phosphatases suppress renal cell carcinoma by stabilizing PML and inhibiting mTOR/HIF signaling

Lin, Y. C., Lu, L. T., Chen, H. Y., Duan, X., Lin, X., Feng, X. H., Tang, M-J. & Chen, R. H., 2014 Dec 1, In : Cancer Research. 74, 23, p. 6935-6946 12 p.

Research output: Contribution to journalArticle

Renal Cell Carcinoma
Phosphoric Monoester Hydrolases
Leukemia
Neoplasms
Down-Regulation
11 Citations (Scopus)
Epithelial-Mesenchymal Transition
Transforming Growth Factors
Actins
Adhesion
Epithelial Cells
8 Citations (Scopus)

Validation of the effects of TGF-β1 on tumor recurrence and prognosis through tumor retrieval and cell mechanical properties

Wu, T. H., Chou, Y. W., Chiu, P. H., Tang, M-J., Hu, C. W. & Yeh, M-L., 2014 Mar 3, In : Cancer Cell International. 14, 1, 20.

Research output: Contribution to journalArticle

Transforming Growth Factor beta1
Recurrence
Neoplasms
Epithelial-Mesenchymal Transition
Neoplasm Metastasis
2013
25 Citations (Scopus)

Enhancement of renal epithelial cell functions through microfluidic-based coculture with adipose-derived stem cells

Huang, H. C., Chang, Y. J., Chen, W. C., Harn, H. I. C., Tang, M-J. & Wu, C-C., 2013 Sep 1, In : Tissue Engineering - Part A. 19, 17-18, p. 2024-2034 11 p.

Research output: Contribution to journalArticle

Microfluidics
Coculture Techniques
Stem cells
Stem Cells
Collagen
37 Citations (Scopus)

Increased aortic stiffness and attenuated lysyl oxidase activity in obesity

Chen, J. Y., Tsai, P. J., Tai, H. C., Tsai, R. L., Chang, Y. T., Wang, M. C., Chiou, Y. W., Yeh, M. L., Tang, M. J., Lam, C. F., Shiesh, S. C., Li, Y. H., Tsai, W. C., Chou, C. H., Lin, L. J., Wu, H. L. & Tsai, Y. S., 2013 Apr 1, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 33, 4, p. 839-846 8 p.

Research output: Contribution to journalArticle

Protein-Lysine 6-Oxidase
Vascular Stiffness
Obesity
Elastin
Aorta
8 Citations (Scopus)
Epithelial-Mesenchymal Transition
Transforming Growth Factors
Epithelial Cells
Switches
Stiffness
2 Citations (Scopus)

Pathogenesis of scars: An overview

Hsu, C-K., Lee, Y-Y. & Tang, M-J., 2013, Scars and Scarring: Causes, Types and Treatment Options. Nova Science Publishers, Inc., p. 41-55 15 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Cicatrix
Keloid
Wound Healing
Skin
Extracellular Matrix
1 Citation (Scopus)

Review series - Mechanotransduction from physiology to disease states

Cheng, C. M. & Tang, M-J., 2013 Feb 1, In : Journal of Cellular and Molecular Medicine. 17, 2, p. 223-224 2 p.

Research output: Contribution to journalEditorial

Cellular Mechanotransduction
20 Citations (Scopus)

The enhancement of biofilm formation in Group B streptococcal isolates at vaginal pH

Ho, Y. R., Li, C. M., Yu, C. H., Lin, Y. J., Wu, C. M., Harn, I. C., Tang, M. J., Chen, Y. T., Shen, F. C., Lu, C. Y., Tsai, T. C. & Wu, J. J., 2013 Apr 1, In : Medical Microbiology and Immunology. 202, 2, p. 105-115 11 p.

Research output: Contribution to journalArticle

Biofilms
Streptococcus agalactiae
Atomic Force Microscopy
Vagina
Pregnant Women
38 Citations (Scopus)

The Influence of Physical and Physiological Cues on Atomic Force Microscopy-Based Cell Stiffness Assessment

Chiou, Y. W., Lin, H. K., Tang, M-J., Lin, H. H. & Yeh, M-L., 2013 Oct 23, In : PloS one. 8, 10, e77384.

Research output: Contribution to journalArticle

atomic force microscopy
Atomic Force Microscopy
Cues
Elasticity
Atomic force microscopy
2012
34 Citations (Scopus)

A tale of two collagen receptors, integrin β1 and discoidin domain receptor 1, in epithelial cell differentiation

Yeh, Y. C., Lin, H. H. & Tang, M. J., 2012 Dec 15, In : American Journal of Physiology - Cell Physiology. 303, 12, p. C1207-C1217

Research output: Contribution to journalReview article

Collagen Receptors
Integrins
Cell Differentiation
Epithelial Cells
Collagen
100 Citations (Scopus)

Instructive nanofiber scaffolds with VEGF create a microenvironment for arteriogenesis and cardiac repair

Lin, Y. D., Luo, C-Y., Hu, Y-N., Yeh, M-L., Hsueh, Y. C., Chang, M. Y., Tsai, D. C., Wang, J-N., Tang, M-J., Wei, E. I. H., Springer, M. L. & Hsieh, P. C. H., 2012 Aug 8, In : Science Translational Medicine. 4, 146, 146ra109.

Research output: Contribution to journalArticle

Nanofibers
Vascular Endothelial Growth Factor A
Cardiac Myocytes
Injections
Regeneration
2011

Adhesion strengths of normal epithelial cells and epithelial mesenchymal transition cells by using single-cell force spectroscopy

Chen, W. L., Chung, Y. S., Chiou, Y. W., Tang, M-J. & Yeh, M-L., 2011 Oct 4, NEMS 2011 - 6th IEEE International Conference on Nano/Micro Engineered and Molecular Systems. p. 499-502 4 p. 6017402. (NEMS 2011 - 6th IEEE International Conference on Nano/Micro Engineered and Molecular Systems).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

adhesion
cells
progressions
spectroscopy
cancer
196 Citations (Scopus)
Uterine Cervical Neoplasms
Calcium
Growth
Neoplasms
Epidermal Growth Factor
44 Citations (Scopus)

DDR1 triggers epithelial cell differentiation by promoting cell adhesion through stabilization of E-cadherin

Yeh, Y. C., Wu, C-C., Wang, Y-G. & Tang, M-J., 2011 Apr 1, In : Molecular Biology of the Cell. 22, 7, p. 940-953 14 p.

Research output: Contribution to journalArticle

Cadherins
Cell Adhesion
Cell Differentiation
Epithelial Cells
Discoidin Domain Receptor 1
2010
8 Citations (Scopus)
Focal Adhesions
cytoskeleton
Cytoskeleton
adhesion
Struts
37 Citations (Scopus)

DDR1 regulates the stabilization of cell surface E-cadherin and E-cadherin-mediated cell aggregation

Eswaramoorthy, R., Wang, C. K., Chen, W. C., Tang, M-J., Ho, M. L., Hwang, C. C., Wang, H. M. & Wang, C. Z., 2010 Aug 1, In : Journal of Cellular Physiology. 224, 2, p. 387-397 11 p.

Research output: Contribution to journalArticle

Cell Aggregation
Cadherins
Agglomeration
Stabilization
Madin Darby Canine Kidney Cells
44 Citations (Scopus)

Mouse kidney progenitor cells accelerate renal regeneration and prolong survival after ischemic injury

Lee, P. T., Lin, H. H., Jiang, S. T., Lu, P-J., Chou, K. J., Fang, H. C., Chiou, Y-Y. & Tang, M-J., 2010 Mar 31, In : Stem Cells. 28, 3, p. 573-584 12 p.

Research output: Contribution to journalArticle

Regeneration
Stem Cells
Kidney
Wounds and Injuries
Adult Stem Cells
2009
18 Citations (Scopus)
STAT3 Transcription Factor
Genetic Promoter Regions
Transcriptional Activation
Cell Count
Madin Darby Canine Kidney Cells
2 Citations (Scopus)

Con-A-carbone nanotube conjugate with short wave near-infrared laser ablation for tumor therapy

Lei, H. Y., Peng, C. A., Tang, M-J., Reinhardt, K. & Szu, H., 2009 Sep 11, Independent Component Analyses, Wavelets, Neural Networks, Biosystems, and Nanoengineering VII. 73430Q. (Proceedings of SPIE - The International Society for Optical Engineering; vol. 7343).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Laser Ablation
Infrared lasers
Laser ablation
Concanavalin A
Nanotubes
40 Citations (Scopus)

DDR1/E-cadherin complex regulates the activation of DDR1 and cell spreading

Wang, C. Z., Yeh, Y. C. & Tang, M-J., 2009 Aug 1, In : American Journal of Physiology - Cell Physiology. 297, 2

Research output: Contribution to journalArticle

Cadherins
Intercellular Junctions
Collagen Receptors
Catenins
Null Lymphocytes
39 Citations (Scopus)

Discoidin domain receptor 1 activation suppresses α2b 1 integrin-dependent cell spreading through inhibition of Cdc42 sctivity

Yi-Chun, Y. E. H., Wang, C. Z. & Tang, M-J., 2009 Jan 1, In : Journal of Cellular Physiology. 218, 1, p. 146-156 11 p.

Research output: Contribution to journalArticle

GTP Phosphohydrolases
Integrins
Chemical activation
Collagen
Blocking Antibodies