• 4097 Citations
  • 38 h-Index
1986 …2020
If you made any changes in Pure these will be visible here soon.

Research Output 1986 2019

Filter
Article
2019

Tks5 and dynamin-2 enhance actin bundle rigidity in invadosomes to promote myoblast fusion

Chuang, M. C., Lin, S. S., Ohniwa, R. L., Lee, G. H., Su, Y. A., Chang, Y. C., Tang, M. J. & Liu, Y. W., 2019 May 1, In : Journal of Cell Biology. 218, 5, p. 1670-1685 16 p.

Research output: Contribution to journalArticle

Open Access
Dynamin II
Myoblasts
Actins
Muscle Development
Actin Cytoskeleton
2018

Bcl-2 regulates store-operated Ca2+ entry to modulate ER stress-induced apoptosis

Chiu, W., Chang, H., Lin, Y., Lin, Y., Chang, H., Lin, H., Huang, S., Tang, M. & Shen, M., 2018 Dec 1, In : Cell Death Discovery. 4, 1

Research output: Contribution to journalArticle

8 Citations (Scopus)

Bcl-2 regulates store-operated Ca2+ entry to modulate ER stress-induced apoptosis

Chiu, W-T., Chang, H. A., Lin, Y. H., Lin, Y. S., Chang, H. T., Lin, H. H., Huang, S. C., Tang, M-J. & Shen, M-R., 2018 Dec 1, In : Cell Death Discovery. 4, 1, 37.

Research output: Contribution to journalArticle

Open Access
Apoptosis
Tunicamycin
Thapsigargin
Mitochondria
Death Domain Receptors
9 Citations (Scopus)

Caveolin-1 Controls Hyperresponsiveness to Mechanical Stimuli and Fibrogenesis-Associated RUNX2 Activation in Keloid Fibroblasts

Hsu, C. K., Lin, H. H., Harn, H. I., Ogawa, R., Wang, Y. K., Ho, Y. T., Chen, W. R., Lee, Y. C., Lee, J. Y. Y., Shieh, S. J., Cheng, C. M., McGrath, J. A. & Tang, M. J., 2018 Jan, In : Journal of Investigative Dermatology. 138, 1, p. 208-218 11 p.

Research output: Contribution to journalArticle

Caveolin 1
Keloid
Fibroblasts
Chemical activation
trichostatin A

Caveolin-1 down-regulation is required for Wnt5a-Frizzled 2 signalling in Ha-RasV12-induced cell transformation

Lin, H. K., Lin, H. H., Chiou, Y. W., Wu, C. L., Chiu, W-T. & Tang, M-J., 2018 May 1, In : Journal of Cellular and Molecular Medicine. 22, 5, p. 2631-2643 13 p.

Research output: Contribution to journalArticle

Caveolin 1
Down-Regulation
Madin Darby Canine Kidney Cells
Exosomes
Conditioned Culture Medium
5 Citations (Scopus)

Coincidence Detection of Membrane Stretch and Extracellular pH by the Proton-Sensing Receptor OGR1 (GPR68)

Wei, W. C., Bianchi, F., Wang, Y-G., Tang, M-J., Ye, H. & Glitsch, M. D., 2018 Dec 3, In : Current Biology. 28, 23, p. 3815-3823.e4

Research output: Contribution to journalArticle

protons
Protons
Membranes
receptors
Acidification
3 Citations (Scopus)

Time Series Integrative Analysis of RNA Sequencing and MicroRNA Expression Data Reveals Key Biologic Wound Healing Pathways in Keloid-Prone Individuals

Onoufriadis, A., Hsu, C-K., Ainali, C., Ung, C. Y., Rashidghamat, E., Yang, H. S., Huang, H. Y., Niazi, U., Tziotzios, C., Yang, J. C., Nuamah, R., Tang, M-J., Saxena, A., de Rinaldis, E. & McGrath, J. A., 2018 Dec 1, In : Journal of Investigative Dermatology. 138, 12, p. 2690-2693 4 p.

Research output: Contribution to journalArticle

Time series analysis
MicroRNAs
RNA
2017
27 Citations (Scopus)

Mechanotransduction of matrix stiffness in regulation of focal adhesion size and number: Reciprocal regulation of caveolin-1 and β1 integrin

Yeh, Y. C., Ling, J. Y., Chen, W. C., Lin, H. H. & Tang, M-J., 2017 Dec 1, In : Scientific reports. 7, 1, 15008.

Research output: Contribution to journalArticle

Caveolin 1
Focal Adhesions
Integrins
Cell Adhesion
Cluster Analysis
6 Citations (Scopus)

Vibrio vulnificus MARTX cytotoxin causes inactivation of phagocytosis-related signaling molecules in macrophages

Chen, C. L., Chien, S. C., Leu, T-H., Harn, H. I. C., Tang, M-J. & Hor, L. I., 2017 Aug 19, In : Journal of biomedical science. 24, 1, 58.

Research output: Contribution to journalArticle

Vibrio vulnificus
Macrophages
Cytotoxins
Phagocytosis
Focal Adhesion Kinase 2
2016
5 Citations (Scopus)

DDR1 promotes E-cadherin stability via inhibition of integrin-β1-Src activation-mediated E-cadherin endocytosis

Chen, H. R., Yeh, Y. C., Liu, C. Y., Wu, Y. T., Lo, F. Y., Tang, M-J. & Wang, Y-G., 2016 Nov 8, In : Scientific reports. 6, 36336.

Research output: Contribution to journalArticle

Cadherins
Endocytosis
Integrins
Clathrin
Discoidin Domain Receptor 1
5 Citations (Scopus)

Role of Excessive Autophagy Induced by Mechanical Overload in Vein Graft Neointima Formation: Prediction and Prevention

Chang, Y. J., Huang, H. C., Hsueh, Y. Y., Wang, S. W., Su, F. C., Chang, C. H., Tang, M. J., Li, Y. S., Wang, S. H., Shung, K. K., Chien, S. & Wu, C. C., 2016 Feb 26, In : Scientific reports. 6, 22147.

Research output: Contribution to journalArticle

Neointima
Autophagy
Veins
Transplants
Ultrasonics
2 Citations (Scopus)

Spatial distribution of filament elasticity determines the migratory behaviors of a cell

Harn, H. I. C., Hsu, C-K., Wang, Y-G., Huang, Y. W., Chiu, W-T., Lin, H. H., Cheng, C. M. & Tang, M-J., 2016 Jul 3, In : Cell Adhesion and Migration. 10, 4, p. 368-377 10 p.

Research output: Contribution to journalArticle

Elasticity
Actin Cytoskeleton
Focal Adhesions
Atomic Force Microscopy
Research
2015
26 Citations (Scopus)

Albumin stimulates renal tubular inflammation through an HSP70-TLR4 axis in mice with early diabetic nephropathy

Jheng, H. F., Tsai, P-J., Chuang, Y. L., Shen, Y. T., Tai, T. A., Chen, W. C., Chou, C. K., Ho, L. C., Tang, M-J., Lai, K. T. A., Sung, J-M. & Tsai, Y-S., 2015 Oct 1, In : DMM Disease Models and Mechanisms. 8, 10, p. 1311-1321 11 p.

Research output: Contribution to journalArticle

HSP70 Heat-Shock Proteins
Diabetic Nephropathies
Albumins
Inflammation
Kidney
20 Citations (Scopus)

Matrix-Stiffness-Regulated Inverse Expression of Krüppel-Like Factor 5 and Krüppel-Like Factor 4 in the Pathogenesis of Renal Fibrosis

Chen, W. C., Lin, H. H. & Tang, M-J., 2015 Sep 1, In : American Journal of Pathology. 185, 9, p. 2468-2481 14 p.

Research output: Contribution to journalArticle

Extracellular Signal-Regulated MAP Kinases
Fibrosis
Kidney
Ureteral Obstruction
Cyclin D1
14 Citations (Scopus)

Mechanical coupling of cytoskeletal elasticity and force generation is crucial for understanding the migrating nature of keloid fibroblasts

Harn, H. I. C., Wang, Y. K., Hsu, C. K., Ho, Y. T., Huang, Y. W., Chiu, W. T., Lin, H. H., Cheng, C. M. & Tang, M. J., 2015 Aug 1, In : Experimental Dermatology. 24, 8, p. 579-584 6 p.

Research output: Contribution to journalArticle

Keloid
Elasticity
Fibroblasts
Spatial distribution
Actins
50 Citations (Scopus)

Mechanical phenotype of cancer cells: Cell softening and loss of stiffness sensing

Lin, H. H., Lin, H. K., Lin, I. H., Chiou, Y. W., Chen, H. W., Liu, C. Y., Harn, H. I. C., Chiu, W-T., Wang, Y-G., Shen, M-R. & Tang, M-J., 2015 Jan 1, In : Oncotarget. 6, 25, p. 20946-20958 13 p.

Research output: Contribution to journalArticle

Phenotype
Caveolin 1
Neoplasms
Fibroblasts
Elasticity
17 Citations (Scopus)

Mechanosensitive store-operated calcium entry regulates the formation of cell polarity

Huang, Y. W., Chang, S. J., I-Chen Harn, H., Huang, H. T., Lin, H. H., Shen, M-R., Tang, M-J. & Chiu, W-T., 2015 Sep 1, In : Journal of Cellular Physiology. 230, 9, p. 2086-2097 12 p.

Research output: Contribution to journalArticle

Cell Polarity
Caveolin 1
Cells
Calcium
Polarization
115 Citations (Scopus)

Vimentin contributes to epithelial-mesenchymal transition ancer cell mechanics by mediating cytoskeletal organization and focal adhesion maturation

Liu, C. Y., Lin, H. H., Tang, M-J. & Wang, Y-G., 2015 Jan 1, In : Oncotarget. 6, 18, p. 15966-15983 18 p.

Research output: Contribution to journalArticle

Focal Adhesions
Epithelial-Mesenchymal Transition
Vimentin
Mechanics
Cytoskeleton
9 Citations (Scopus)

β-PIX controls intracellular viscoelasticity to regulate lung cancer cell migration

Yu, H. W., Chen, Y. Q., Huang, C. M., Liu, C. Y., Chiou, A., Wang, Y-G., Tang, M-J. & Kuo, J. C., 2015 May 1, In : Journal of Cellular and Molecular Medicine. 19, 5, p. 934-947 14 p.

Research output: Contribution to journalArticle

Focal Adhesions
Cell Movement
Lung Neoplasms
Actins
Actin Cytoskeleton
2014
22 Citations (Scopus)

A nanopatterned cell-seeded cardiac patch prevents electro-uncoupling and improves the therapeutic efficacy of cardiac repair

Lin, Y. D., Ko, M. C., Wu, S. T., Li, S. F., Hu, J. F., Lai, Y. J., Harn, H. I. C., Laio, I. C., Yeh, M-L., Yeh, H. I., Tang, M-J., Chang, K-C., Su, F., Wei, E. I. H., Lee, S. T., Chen, J. H., Hoffman, A. S., Wu, W. T. & Hsieh, P. C. H., 2014 Jan 1, In : Biomaterials Science. 2, 4, p. 567-580 14 p.

Research output: Contribution to journalArticle

Endothelial cells
Repair
Anisotropy
Medical nanotechnology
Hemodynamics
11 Citations (Scopus)

Caveolin-1 alters the pattern of cytoplasmic Ca2+ oscillations and Ca2+-dependent gene expression by enhancing leukotriene receptor desensitization

Yeh, Y. C., Tang, M-J. & Parekh, A. B., 2014 Jun 20, In : Journal of Biological Chemistry. 289, 25, p. 17843-17853 11 p.

Research output: Contribution to journalArticle

Leukotriene Receptors
Caveolin 1
Gene expression
Gene Expression
Type C Phospholipases
16 Citations (Scopus)

GEF-H1 controls focal adhesion signaling that regulates mesenchymal stem cell lineage commitment

Huang, I. H., Hsiao, C. T., Wu, J. C., Shen, R. F., Liu, C. Y., Wang, Y-G., Chen, Y. C., Huang, C. M., del Álamo, J. C., Chang, Z. F., Tang, M-J., Khoo, K. H. & Kuo, J. C., 2014 Jan 1, In : Journal of Cell Science. 127, 19, p. 4186-4200 15 p.

Research output: Contribution to journalArticle

Focal Adhesions
Cell Lineage
Mesenchymal Stromal Cells
Stress Fibers
Osteogenesis
24 Citations (Scopus)
Cell Differentiation
Cell Proliferation
Epithelial Cells
Epithelial-Mesenchymal Transition
Transforming Growth Factors
12 Citations (Scopus)

SCP phosphatases suppress renal cell carcinoma by stabilizing PML and inhibiting mTOR/HIF signaling

Lin, Y. C., Lu, L. T., Chen, H. Y., Duan, X., Lin, X., Feng, X. H., Tang, M-J. & Chen, R. H., 2014 Dec 1, In : Cancer Research. 74, 23, p. 6935-6946 12 p.

Research output: Contribution to journalArticle

Renal Cell Carcinoma
Phosphoric Monoester Hydrolases
Leukemia
Neoplasms
Down-Regulation
11 Citations (Scopus)
Epithelial-Mesenchymal Transition
Transforming Growth Factors
Actins
Adhesion
Epithelial Cells
8 Citations (Scopus)

Validation of the effects of TGF-β1 on tumor recurrence and prognosis through tumor retrieval and cell mechanical properties

Wu, T. H., Chou, Y. W., Chiu, P. H., Tang, M-J., Hu, C. W. & Yeh, M-L., 2014 Mar 3, In : Cancer Cell International. 14, 1, 20.

Research output: Contribution to journalArticle

Transforming Growth Factor beta1
Recurrence
Neoplasms
Epithelial-Mesenchymal Transition
Neoplasm Metastasis
2013
25 Citations (Scopus)

Enhancement of renal epithelial cell functions through microfluidic-based coculture with adipose-derived stem cells

Huang, H. C., Chang, Y. J., Chen, W. C., Harn, H. I. C., Tang, M-J. & Wu, C-C., 2013 Sep 1, In : Tissue Engineering - Part A. 19, 17-18, p. 2024-2034 11 p.

Research output: Contribution to journalArticle

Microfluidics
Coculture Techniques
Stem cells
Stem Cells
Collagen
37 Citations (Scopus)

Increased aortic stiffness and attenuated lysyl oxidase activity in obesity

Chen, J. Y., Tsai, P. J., Tai, H. C., Tsai, R. L., Chang, Y. T., Wang, M. C., Chiou, Y. W., Yeh, M. L., Tang, M. J., Lam, C. F., Shiesh, S. C., Li, Y. H., Tsai, W. C., Chou, C. H., Lin, L. J., Wu, H. L. & Tsai, Y. S., 2013 Apr 1, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 33, 4, p. 839-846 8 p.

Research output: Contribution to journalArticle

Protein-Lysine 6-Oxidase
Vascular Stiffness
Obesity
Elastin
Aorta
8 Citations (Scopus)
Epithelial-Mesenchymal Transition
Transforming Growth Factors
Epithelial Cells
Switches
Stiffness
20 Citations (Scopus)

The enhancement of biofilm formation in Group B streptococcal isolates at vaginal pH

Ho, Y. R., Li, C. M., Yu, C. H., Lin, Y. J., Wu, C. M., Harn, I. C., Tang, M. J., Chen, Y. T., Shen, F. C., Lu, C. Y., Tsai, T. C. & Wu, J. J., 2013 Apr 1, In : Medical Microbiology and Immunology. 202, 2, p. 105-115 11 p.

Research output: Contribution to journalArticle

Biofilms
Streptococcus agalactiae
Atomic Force Microscopy
Vagina
Pregnant Women
38 Citations (Scopus)

The Influence of Physical and Physiological Cues on Atomic Force Microscopy-Based Cell Stiffness Assessment

Chiou, Y. W., Lin, H. K., Tang, M-J., Lin, H. H. & Yeh, M-L., 2013 Oct 23, In : PloS one. 8, 10, e77384.

Research output: Contribution to journalArticle

atomic force microscopy
Atomic Force Microscopy
Cues
Elasticity
Atomic force microscopy
2012
100 Citations (Scopus)

Instructive nanofiber scaffolds with VEGF create a microenvironment for arteriogenesis and cardiac repair

Lin, Y. D., Luo, C-Y., Hu, Y-N., Yeh, M-L., Hsueh, Y. C., Chang, M. Y., Tsai, D. C., Wang, J-N., Tang, M-J., Wei, E. I. H., Springer, M. L. & Hsieh, P. C. H., 2012 Aug 8, In : Science Translational Medicine. 4, 146, 146ra109.

Research output: Contribution to journalArticle

Nanofibers
Vascular Endothelial Growth Factor A
Cardiac Myocytes
Injections
Regeneration
2011
196 Citations (Scopus)
Uterine Cervical Neoplasms
Calcium
Growth
Neoplasms
Epidermal Growth Factor
44 Citations (Scopus)

DDR1 triggers epithelial cell differentiation by promoting cell adhesion through stabilization of E-cadherin

Yeh, Y. C., Wu, C-C., Wang, Y-G. & Tang, M-J., 2011 Apr 1, In : Molecular Biology of the Cell. 22, 7, p. 940-953 14 p.

Research output: Contribution to journalArticle

Cadherins
Cell Adhesion
Cell Differentiation
Epithelial Cells
Discoidin Domain Receptor 1
2010
8 Citations (Scopus)
Focal Adhesions
cytoskeleton
Cytoskeleton
adhesion
Struts
37 Citations (Scopus)

DDR1 regulates the stabilization of cell surface E-cadherin and E-cadherin-mediated cell aggregation

Eswaramoorthy, R., Wang, C. K., Chen, W. C., Tang, M-J., Ho, M. L., Hwang, C. C., Wang, H. M. & Wang, C. Z., 2010 Aug 1, In : Journal of Cellular Physiology. 224, 2, p. 387-397 11 p.

Research output: Contribution to journalArticle

Cell Aggregation
Cadherins
Agglomeration
Stabilization
Madin Darby Canine Kidney Cells
44 Citations (Scopus)

Mouse kidney progenitor cells accelerate renal regeneration and prolong survival after ischemic injury

Lee, P. T., Lin, H. H., Jiang, S. T., Lu, P-J., Chou, K. J., Fang, H. C., Chiou, Y-Y. & Tang, M-J., 2010 Mar 31, In : Stem Cells. 28, 3, p. 573-584 12 p.

Research output: Contribution to journalArticle

Regeneration
Stem Cells
Kidney
Wounds and Injuries
Adult Stem Cells
2009
40 Citations (Scopus)

DDR1/E-cadherin complex regulates the activation of DDR1 and cell spreading

Wang, C. Z., Yeh, Y. C. & Tang, M-J., 2009 Aug 1, In : American Journal of Physiology - Cell Physiology. 297, 2

Research output: Contribution to journalArticle

Cadherins
Intercellular Junctions
Collagen Receptors
Catenins
Null Lymphocytes
39 Citations (Scopus)

Discoidin domain receptor 1 activation suppresses α2b 1 integrin-dependent cell spreading through inhibition of Cdc42 sctivity

Yi-Chun, Y. E. H., Wang, C. Z. & Tang, M-J., 2009 Jan 1, In : Journal of Cellular Physiology. 218, 1, p. 146-156 11 p.

Research output: Contribution to journalArticle

GTP Phosphohydrolases
Integrins
Chemical activation
Collagen
Blocking Antibodies
8 Citations (Scopus)

Effect of D to E mutation of the RGD motif in rhodostomin on its activity, structure, and dynamics: Importance of the interactions between the D residue and integrin

Chen, C. Y., Shiu, J. H., Hsieh, Y. H., Liu, Y. C., Chen, Y. C., Chen, Y. C., Jeng, W-Y., Tang, M-J., Lo, S. J. & Chuang, W-J., 2009 Sep 1, In : Proteins: Structure, Function and Bioinformatics. 76, 4, p. 808-821 14 p.

Research output: Contribution to journalArticle

Integrins
Mutation
Platelets
Platelet Aggregation
Hydrogen
7 Citations (Scopus)

Requirement of focal adhesion kinase in branching tubulogenesis

Wei, W. C., Kopec, A. K. & Tang, M. J., 2009 Apr 6, In : Journal of biomedical science. 16, 1, 5.

Research output: Contribution to journalArticle

Focal Adhesion Protein-Tyrosine Kinases
Clone Cells
Gels
Collagen
Hepatocyte Growth Factor
2008
186 Citations (Scopus)
Epithelial-Mesenchymal Transition
Snails
Epidermal Growth Factor Receptor
Uterine Cervical Neoplasms
Up-Regulation
7 Citations (Scopus)

Low substratum rigidity of collagen gel promotes ERK phosphorylation via lipid raft to augment cell migration

Wei, W. C., Hsu, Y. C., Chiu, W-T., Wang, C. Z., Wu, C. M., Wang, Y-G., Shen, M-R. & Tang, M-J., 2008 Mar 1, In : Journal of Cellular Biochemistry. 103, 4, p. 1111-1124 14 p.

Research output: Contribution to journalArticle

Phosphorylation
Rigidity
Cell Movement
Collagen
Gels
44 Citations (Scopus)

Mechanosensing machinery for cells under low substratum rigidity

Wei, W. C., Lin, H. H., Shen, M-R. & Tang, M-J., 2008 Dec 1, In : American Journal of Physiology - Cell Physiology. 295, 6

Research output: Contribution to journalArticle

Integrins
Cluster Analysis
Focal Adhesion Kinase 1
Collagen
Phosphorylation
30 Citations (Scopus)
Calpain
Up-Regulation
Epithelial Cells
Apoptosis
Homeostasis
38 Citations (Scopus)

Targeted disruption of Nphp1 causes male infertility due to defects in the later steps of sperm morphogenesis in mice

Jiang, S. T., Chiou, Y-Y., Wang, E., Lin, H. K., Lee, S. P., Lu, H. Y., Wang, C. K. L., Tang, M-J. & Li, H., 2008 Oct 29, In : Human Molecular Genetics. 17, 21, p. 3368-3379 12 p.

Research output: Contribution to journalArticle

Spermatids
Male Infertility
Morphogenesis
Spermatozoa
Sperm Tail
2007
7 Citations (Scopus)

Activation of caspase-8 and Erk-1/2 in domes regulates cell death induced by confluence in MDCK cells

Chang, Y. H., Lin, H. H., Wang, Y-G., Chiu, W-T., Su, H. W. & Tang, M-J., 2007 Apr 1, In : Journal of Cellular Physiology. 211, 1, p. 174-182 9 p.

Research output: Contribution to journalArticle

Madin Darby Canine Kidney Cells
Caspase 8
Domes
Cell death
Cell Death
31 Citations (Scopus)
STAT3 Transcription Factor
Domes
Chemical activation
Madin Darby Canine Kidney Cells
sodium-hydrogen exchanger 3
23 Citations (Scopus)

Deregulation of AP-1 proteins in collagen gel-induced epithelial cell apoptosis mediated by low substratum rigidity

Wang, Y. H., Chiu, W-T., Wang, Y-G., Wu, C. C., Chen, T. L., Teng, C. F., Chang, W-T., Chang, H-C. & Tang, M-J., 2007 Jan 5, In : Journal of Biological Chemistry. 282, 1, p. 752-763 12 p.

Research output: Contribution to journalArticle

Deregulation
Transcription Factor AP-1
Rigidity
Collagen
Gels
51 Citations (Scopus)

KCl cotransporter-3 down-regulates E-cadherin/β-catenin complex to promote epithelial-mesenchymal transition

Hsu, Y. M., Chen, Y. F., Chou, C-Y., Tang, M-J., Chen, J. H., Wilkins, R. J., Clive Ellory, J. & Shen, M-R., 2007 Nov 15, In : Cancer Research. 67, 22, p. 11064-11073 10 p.

Research output: Contribution to journalArticle

Catenins
Epithelial-Mesenchymal Transition
Cadherins
Down-Regulation
Vimentin