• 7119 Citations
  • 30 h-Index
19942019
If you made any changes in Pure these will be visible here soon.

Research Output 1994 2019

  • 7119 Citations
  • 30 h-Index
  • 59 Article
  • 48 Patent
  • 6 Review article
2019

Blocking IL-19 signaling ameliorates allergen-induced airway inflammation

Weng, Y. H., Chen, W. Y., Lin, Y. L., Wang, J-Y. & Chang, M-S., 2019 Jan 1, In : Frontiers in Immunology. 10, APR, 968.

Research output: Contribution to journalArticle

Open Access
Allergens
Asthma
Inflammation
Cytokines
Rodentia
2018
1 Citation (Scopus)

IL-20 bone diseases involvement and therapeutic target potential

Wang, H. H., Hsu, Y. H. & Chang, M. S., 2018 Apr 24, In : Journal of biomedical science. 25, 1, 38.

Research output: Contribution to journalReview article

Bone Diseases
Bone
Bone and Bones
Osteolysis
Osteogenesis
1 Citation (Scopus)
Diabetic Nephropathies
Chronic Renal Insufficiency
Renal Insufficiency
Diabetes Complications
Chemokines
2017
5 Citations (Scopus)

Anti-IL-20 monoclonal antibody inhibited inflammation and protected against cartilage destruction in murine models of osteoarthritis

Hsu, Y-H., Yang, Y. Y., Huwang, M. H., Weng, Y. H., Jou, I. M., Wu, P-T., Lin, T. Y., Wu, L-W. & Chang, M-S., 2017 Apr 1, In : PLoS ONE. 12, 4, e0175802.

Research output: Contribution to journalArticle

osteoarthritis
Cartilage
interleukins
cartilage
Osteoarthritis

Anti-IL-20 monoclonal antibody inhibited tumor growth in hepatocellular carcinoma

Chiu, Y. S., Hsing, C. H., Li, C. F., Lee, C. Y., Hsu, Y. H. & Chang, M. S., 2017 Dec 1, In : Scientific reports. 7, 1, 17609.

Research output: Contribution to journalArticle

Hepatocellular Carcinoma
Monoclonal Antibodies
Growth
Cyclin D1
Neoplasms
6 Citations (Scopus)

IL-20 in rheumatoid arthritis

Hsu, Y-H. & Chang, M-S., 2017 Jun 1, In : Drug Discovery Today. 22, 6, p. 960-964 5 p.

Research output: Contribution to journalReview article

Rheumatoid Arthritis
Osteitis
Autoimmune Diseases
Joints
Clinical Trials
1 Citation (Scopus)

Interleukin-20 targets podocytes and is upregulated in experimental murine diabetic nephropathy

Hsu, Y. H., Li, H. H., Sung, J. M., Chen, W. Y., Hou, Y. C., Weng, Y. H., Lai, W. T., Wu, C. H. & Chang, M. S., 2017 Mar 3, In : Experimental and Molecular Medicine. 49, 3, e310.

Research output: Contribution to journalArticle

Podocytes
Diabetic Nephropathies
Interleukins
Medical problems
Blood Glucose
2016
8 Citations (Scopus)

Anti-IL-20 monoclonal antibody promotes bone fracture healing through regulating IL-20-mediated osteoblastogenesis

Hsu, Y. H., Chiu, Y. S., Chen, W. Y., Huang, K. Y., Jou, I. M., Wu, P. T., Wu, C. H. & Chang, M. S., 2016 Apr 14, In : Scientific reports. 6, 24339.

Research output: Contribution to journalArticle

Fracture Healing
Bone Fractures
Monoclonal Antibodies
Osteoblasts
Osteogenesis
2015
5 Citations (Scopus)

Anti-IL-20 monoclonal antibody suppresses prostate cancer growth and bone osteolysis in murine models

Hsu, Y. H., Wu, C. Y., Hsing, C. H., Lai, W. T., Wu, L. W. & Chang, M. S., 2015 Oct 6, In : PloS one. 10, 10, e0139871.

Research output: Contribution to journalArticle

Bone Neoplasms
Osteolysis
prostatic neoplasms
interleukins
monoclonal antibodies
2 Citations (Scopus)

Effects of methionine restriction and endurance exercise on bones of ovariectomized rats: A study of histomorphometry, densitometry, and biomechanical properties

Huang, T-H., Su, I. H., Lewis, J. L., Chang, M-S., Hsu, A. T., Perrone, C. E. & Ables, G. P., 2015 Sep 1, In : Journal of Applied Physiology. 119, 5, p. 517-526 10 p.

Research output: Contribution to journalArticle

Densitometry
Methionine
Bone and Bones
Estrogens
Diet
2014
19 Citations (Scopus)

A methionine-restricted diet and endurance exercise decrease bone mass and extrinsic strength but increase intrinsic strength in growing male rats

Huang, T-H., Lewis, J. L., Lin, H. S., Kuo, L. T., Mao, S. W., Tai, Y. S., Chang, M-S., Ables, G. P., Perrone, C. E. & Yang, R. S., 2014 Jan 1, In : Journal of Nutrition. 144, 5, p. 621-630 10 p.

Research output: Contribution to journalArticle

Methionine
Diet
Bone and Bones
Bone Density
Body Weight
26 Citations (Scopus)

IL-20 and IL-20R1 antibodies protect against liver fibrosis

Chiu, Y. S., Wei, C. C., Lin, Y-J., Hsu, Y-H. & Chang, M-S., 2014 Jan 1, In : Hepatology. 60, 3, p. 1003-1014 12 p.

Research output: Contribution to journalArticle

Interleukins
Liver Cirrhosis
Antibodies
Transforming Growth Factors
Liver
8 Citations (Scopus)

The therapeutic potential of anti-interleukin-20 monoclonal antibody

Hsu, Y-H. & Chang, M-S., 2014 Jan 1, In : Cell Transplantation. 23, 4-5, p. 631-639 9 p.

Research output: Contribution to journalReview article

Monoclonal antibodies
Monoclonal Antibodies
Interleukins
Bioactivity
Tumors

Treatment of Osteoarthritis Using IL-20 Antagonists

Chang, M-S., 2014 Jan 23, Patent No. 9221904

Research output: Patent

Osteoarthritis
Antibodies
interleukin 20
2013
6 Citations (Scopus)

Inhibiting Interleukin-19 Activity Ameliorates Esophageal Squamous Cell Carcinoma Progression

Hsing, C. H., Kwok, F. A., Cheng, H-C., Li, C. F. & Chang, M-S., 2013 Oct 9, In : PloS one. 8, 10, e75254.

Research output: Contribution to journalArticle

Interleukins
squamous cell carcinoma
interleukins
Tumors
esophageal neoplasms
23 Citations (Scopus)

Interleukin (IL)-19 promoted skin wound healing by increasing fibroblast keratinocyte growth factor expression

Sun, D. P., Yeh, C. H., So, E., Wang, L. Y., Wei, T. S., Chang, M-S. & Hsing, C. H., 2013 Jun 1, In : Cytokine. 62, 3, p. 360-368 9 p.

Research output: Contribution to journalArticle

Fibroblast Growth Factor 7
Fibroblast Growth Factors
Interleukins
Fibroblasts
Wound Healing
12 Citations (Scopus)

Interleukin-19 in breast cancer

Chen, Y. Y., Li, C. F., Yeh, C. H., Chang, M. S. & Hsing, C. H., 2013 May 27, In : Clinical and Developmental Immunology. 2013, 294320.

Research output: Contribution to journalReview article

Interleukins
Breast Neoplasms
Tumor Microenvironment
Uremia
Septic Shock
13 Citations (Scopus)

Interleukin-19 Mediates Tissue Damage in Murine Ischemic Acute Kidney Injury

Hsu, Y-H., Li, H. H., Sung, J-M., Chen, W. T., Hou, Y. C. & Chang, M-S., 2013 Feb 26, In : PloS one. 8, 2, e56028.

Research output: Contribution to journalArticle

Interleukins
interleukins
Acute Kidney Injury
Liver
Mercuric Chloride
2012
15 Citations (Scopus)

Anti-IL-20 monoclonal antibody alleviates inflammation in oral cancer and suppresses tumor growth

Hsu, Y. H., Wei, C. C., Shieh, D. B., Chan, C. H. & Chang, M. S., 2012 Nov 1, In : Molecular Cancer Research. 10, 11, p. 1430-1439 10 p.

Research output: Contribution to journalArticle

Mouth Neoplasms
Monoclonal Antibodies
Inflammation
Growth
Neoplasms
31 Citations (Scopus)

Anti-IL-20 monoclonal antibody suppresses breast cancer progression and bone osteolysis in murine models

Hsu, Y. H., Hsing, C. H., Li, C. F., Chan, C. H., Chang, M. C., Yan, J. J. & Chang, M. S., 2012 Feb 15, In : Journal of Immunology. 188, 4, p. 1981-1991 11 p.

Research output: Contribution to journalArticle

Bone Neoplasms
Osteolysis
Monoclonal Antibodies
Breast Neoplasms
Neoplasms
29 Citations (Scopus)

Interleukin-19 blockade attenuates collagen-induced arthritis in rats

Hsu, Y-H., Hsieh, P. P. & Chang, M-S., 2012 Mar 1, In : Rheumatology. 51, 3, p. 434-442 9 p., ker127.

Research output: Contribution to journalArticle

Experimental Arthritis
Interleukins
RANK Ligand
Interleukin-1
Interleukin-6
29 Citations (Scopus)

Upregulated IL-19 in breast cancer promotes tumor progression and affects clinical outcome

Hsing, C. H., Cheng, H-C., Hsu, Y-H., Chan, C. H., Yeh, C. H., Li, C. F. & Chang, M-S., 2012 Feb 1, In : Clinical Cancer Research. 18, 3, p. 713-725 13 p.

Research output: Contribution to journalArticle

Interleukins
Breast Neoplasms
Neoplasms
Cell Movement
Carcinoma, Ductal, Breast
2011
40 Citations (Scopus)

Anti-IL-20 monoclonal antibody inhibits the differentiation of osteoclasts and protects against osteoporotic bone loss

Hsu, Y-H., Chen, W. Y., Chan, C. H., Wu, C-H., Sun, Z-J. & Chang, M-S., 2011 Aug 29, In : Journal of Experimental Medicine. 208, 9, p. 1849-1861 13 p.

Research output: Contribution to journalArticle

Osteoclasts
Monoclonal Antibodies
Bone and Bones
Osteogenesis
RANK Ligand
16 Citations (Scopus)

Induced interleukin-19 contributes to cell-mediated immunosuppression in patients undergoing coronary artery bypass grafting with cardiopulmonary bypass

Yeh, C. H., Cheng, B. C., Hsu, C. C., Chen, H. W., Wang, J. J., Chang, M. S. & Hsing, C. H., 2011 Oct 1, In : Annals of Thoracic Surgery. 92, 4, p. 1252-1259 8 p.

Research output: Contribution to journalArticle

Interleukins
Cardiopulmonary Bypass
Coronary Artery Bypass
Immunosuppression
T-Lymphocytes
Osteoporosis
Rheumatoid Arthritis
Peptides
Antibodies
interleukin 20
Osteoporosis
Antibodies
interleukin 20
2010
40 Citations (Scopus)

Interleukin-20 antibody is a potential therapeutic agent for experimental arthritis

Hsu, Y-H. & Chang, M-S., 2010 Nov 1, In : Arthritis and Rheumatism. 62, 11, p. 3311-3321 11 p.

Research output: Contribution to journalArticle

Experimental Arthritis
Antibodies
Arthritis
Therapeutics
Th17 Cells

Use of Anti-IL-20 antibody for treating osteoporosis (as amended)

Chang, M-S., 2010 Apr 8, Patent No. 7837994

Research output: Patent

Osteoporosis
Rheumatoid Arthritis
Peptides
Antibodies
interleukin 20

Use of Anti-IL-20 antibody for treating stroke

Chang, M-S., 2010 Apr 8, Patent No. 8012478

Research output: Patent

Bone Neoplasms
Anti-Idiotypic Antibodies
Stroke
Breast Neoplasms
Antibodies
2009
Psoriatic Arthritis
Antibodies
Stomach Ulcer
Psoriasis
Acute Kidney Injury
45 Citations (Scopus)

IL-20 Is regulated by hypoxia-inducible factor and up-regulated after experimental ischemic stroke

Chen, W. Y. & Chang, M-S., 2009 Apr 15, In : Journal of Immunology. 182, 8, p. 5003-5012 10 p.

Research output: Contribution to journalArticle

Stroke
Glioblastoma
Hypoxia
interleukin 20
Up-Regulation
2 Citations (Scopus)

Mouse interleukin-20 receptor 1a targets renal epithelial cells and is associated with renal calcium deposition

Wei, C. C. & Chang, M-S., 2009 Jan 1, In : Genes and Immunity. 10, 3, p. 237-247 11 p.

Research output: Contribution to journalArticle

Calcium Oxalate
Epithelial Cells
Calcium
Kidney
Tumor Necrosis Factor-alpha
2008
11 Citations (Scopus)

A novel transcript of mouse interleukin-20 receptor acts on glomerular mesangial cells as an aggravating factor in lupus nephritis

Wei, C. C. & Chang, M-S., 2008 Sep 5, In : Genes and Immunity. 9, 8, p. 668-679 12 p.

Research output: Contribution to journalArticle

Lupus Nephritis
Mesangial Cells
Inbred NZB Mouse
B-Lymphocytes
Spleen
Psoriatic Arthritis
Antibodies
Stomach Ulcer
Psoriasis
Acute Kidney Injury
40 Citations (Scopus)

IL-19 is involved in the pathogenesis of endotoxic shock

Hsing, C. H., Chiu, C. J., Chang, L. Y., Hsu, C. C. & Chang, M-S., 2008 Jan 1, In : Shock. 29, 1, p. 7-15 9 p.

Research output: Contribution to journalArticle

Septic Shock
Lung
Liver
Neutrophils
Epithelial Cells
32 Citations (Scopus)

IL-20 may contribute to the pathogenesis of human intervertebral disc herniation

Huang, K-Y., Lin, R. M., Chen, W. Y., Lee, C. L., Yan, J. J. & Chang, M-S., 2008 Sep 1, In : Spine. 33, 19, p. 2034-2040 7 p.

Research output: Contribution to journalArticle

Intervertebral Disc
Interleukin-1
Intervertebral Disc Displacement
Interleukin-6
Interleukin-8
19 Citations (Scopus)

Interleukin-20 induced cell death in renal epithelial cells and was associated with acute renal failure

Li, H. H., Hsu, Y. H., Wei, C. C., Lee, P. T., Chen, W. C. & Chang, M. S., 2008 Jul 1, In : Genes and Immunity. 9, 5, p. 395-404 10 p.

Research output: Contribution to journalArticle

Acute Kidney Injury
Cell Death
Epithelial Cells
Kidney
Transforming Growth Factors
19 Citations (Scopus)

Interleukin-20 targets renal cells and is associated with chronic kidney disease

Wei, C. C., Li, H. H., Hsu, Y-H., Hsing, C. H., Sung, J-M. & Chang, M-S., 2008 Sep 26, In : Biochemical and Biophysical Research Communications. 374, 3, p. 448-453 6 p.

Research output: Contribution to journalArticle

Chronic Renal Insufficiency
Kidney
Rats
Epithelial Cells
Fibroblasts
30 Citations (Scopus)

Interleukin-20 targets renal mesangial cells and is associated with lupus nephritis

Li, H. H., Cheng, H. H., Sun, K. H., Wei, C. C., Li, C. F., Chen, W. C., Wu, W. M. & Chang, M. S., 2008 Nov 1, In : Clinical Immunology. 129, 2, p. 277-285 9 p.

Research output: Contribution to journalArticle

Lupus Nephritis
Mesangial Cells
Systemic Lupus Erythematosus
Interleukin-10
Inbred NZB Mouse
23 Citations (Scopus)

The distribution of interleukin-19 in healthy and neoplastic tissue

Hsing, C. H., Li, H. H., Hsu, Y. H., Ho, C. L., Chuang, S. S., Lan, K. M. & Chang, M. S., 2008 Nov 1, In : Cytokine. 44, 2, p. 221-228 8 p.

Research output: Contribution to journalArticle

Interleukins
Tissue
Squamous Cell Carcinoma
Tumors
Mouth
2007
31 Citations (Scopus)

Expression of IL-19 correlates with Th2 cytokines in uraemic patients

Hsing, C. H., Hsu, C. C., Chen, W. Y., Chang, L. Y., Hwang, J. C. & Chang, M. S., 2007 Aug 1, In : Nephrology Dialysis Transplantation. 22, 8, p. 2230-2238 9 p.

Research output: Contribution to journalArticle

Interleukins
Cytokines
Monocytes
Serum
T-Lymphocytes
50 Citations (Scopus)

The in vivo biological effects of intradiscal recombinant human bone morphogenetic protein-2 on the injured intervertebral disc: An animal experiment

Huang, K-Y., Yan, J. J., Hsieh, C. C., Chang, M-S. & Lin, R. M., 2007 May 1, In : Spine. 32, 11, p. 1174-1180 7 p.

Research output: Contribution to journalArticle

Intervertebral Disc
Anthozoa
Tears
recombinant human bone morphogenetic protein-2
Fibroblasts
2006
4 Citations (Scopus)

Alignment using genetic programming with causal trees for identification of protein functions

Hung, C. M., Huang, Y-M. & Chang, M-S., 2006 Sep 1, In : Nonlinear Analysis, Theory, Methods and Applications. 65, 5, p. 1070-1093 24 p.

Research output: Contribution to journalArticle

Genetic programming
Genetic Programming
Identification (control systems)
Alignment
Proteins
1 Citation (Scopus)

CSAM: Using clustering-hashing-signal anchoring method to explore human novel genes

Hung, C. M., Huang, Y. M. & Chang, M. S., 2006 Dec 1, In : Journal of Computational Biology. 13, 10, p. 1775-1789 15 p.

Research output: Contribution to journalArticle

Hashing
Cluster Analysis
Genes
Clustering
Gene
104 Citations (Scopus)

Function of interleukin-20 as a proinflammatory molecule in rheumatoid and experimental arthritis

Hsu, Y-H., Li, H. H., Hsieh, M. Y., Liu, M-F., Huang, K-Y., Chin, L. S., Chen, P. C., Cheng, H. H. & Chang, M-S., 2006 Sep 1, In : Arthritis and Rheumatism. 54, 9, p. 2722-2733 12 p.

Research output: Contribution to journalArticle

Experimental Arthritis
Rheumatoid Arthritis
Fibroblasts
Arthritis
Synovial Fluid
52 Citations (Scopus)

IL-20: Biological functions and clinical implications

Wei, C. C., Hsu, Y. H., Li, H. H., Wang, Y. C., Hsieh, M. Y., Chen, W. Y., Hsing, C. H. & Chang, M. S., 2006 Sep 1, In : Journal of biomedical science. 13, 5, p. 601-612 12 p.

Research output: Contribution to journalReview article

Rheumatoid Arthritis
Atherosclerosis
Inflammation
Bioactivity
Interleukin-10
65 Citations (Scopus)

IL-20 is expressed in atherosclerosis plaques and promotes atherosclerosis in apolipoprotein E-deficient mice

Chen, W. Y., Cheng, B. C., Jiang, M. J., Hsieh, M. Y. & Chang, M. S., 2006 Sep 1, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 26, 9, p. 2090-2095 6 p.

Research output: Contribution to journalArticle

Apolipoproteins E
Atherosclerosis
Human Umbilical Vein Endothelial Cells
Cytokines
Monocytes
34 Citations (Scopus)

Induction of Interleukin-19 and Interleukin-22 After Cardiac Surgery With Cardiopulmonary Bypass

Hsing, C. H., Hsieh, M. Y., Chen, W. Y., Cheung So, E., Cheng, B. C. & Chang, M-S., 2006 Jun 1, In : Annals of Thoracic Surgery. 81, 6, p. 2196-2201 6 p.

Research output: Contribution to journalArticle

Interleukins
Cardiopulmonary Bypass
Thoracic Surgery
Interleukin-6
Cytokines

interleukin-20,monoclonal antibody 7e, and uses thereof

Chang, M-S., 2006 Jun 29, Patent No. 7435800

Research output: Patent

Bone Neoplasms
Anti-Idiotypic Antibodies
Monoclonal Antibodies
Breast Neoplasms
Antibodies
86 Citations (Scopus)

Interleukin-20 promotes angiogenesis in a direct and indirect manner

Hsieh, M. Y., Chen, W. Y., Jiang, M. J., Cheng, B. C., Huang, T. Y. & Chang, M. S., 2006 Apr 1, In : Genes and Immunity. 7, 3, p. 234-242 9 p.

Research output: Contribution to journalArticle

Human Umbilical Vein Endothelial Cells
Endothelial Cells
Interleukin-10
interleukin 20
Matrix Metalloproteinases