Nan-Shan Chang

Professor

  • 2708 Citations
  • 27 h-Index
1985 …2020

Research output per year

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Personal profile

Education

  • 1984 PhD, Immunology,Medical Univ. of S. Carolina Charleston, S. Carolina.

Research Interests

  • Apoptosis Signaling
  • Signal transduction

Experience

  • 1977 winter Research Assistant, Tungkang Marine Laboratory, Tungkang, Taiwan
  • 1978/7~1980/7 Teaching Assistant, National Taiwan Normal Univ., Department of Biology
  • 1982 Teaching Assistant of Dental Microbiology for one semester, Medical Univ. of South Carolina, Dept. of Basic & Clinical Immunology & Microbiology
  • 1985/1~1986/12 Post Doctoral Fellow, The Samuel Roberts Noble Foundation, Immunology Section
  • 1987/1~1989/6 Instructor, University of Massachusetts Medical Center, Department of Biochemistry
  • 1989/09~ Adjunct Associate Professor, Medical University of South Carolina, College of Dental Medicine
  • 1989/7~1995/6 Assistant Scientist and Laboratory Director, Guthrie Research Institute, Laboratory of Molecular Immunology & Protein/Peptide Microsequencing Core Facility
  • 1991/01~ Consultant, GlycoMed Research Incorporated, Hastings on Hudson, NY
  • 1995/7~2005/12 Associate Scientist and Laboratory Director, Guthrie Research Institute, Laboratory of Molecular Immunology & Protein/Peptide Microsequencing Core Facility
  • 1996/3~2006/8 Adjunct Research Associate Professor, Upstate Medical University at Syracuse, Department of Immunology and Microbiology & Integrated Medicine
  • 2006/11~ Distinguished Professor,Institute of Molecular Medicine, College of Medicine, National Cheng Kung University
  • 2006/11~ Professor, Institute of Molecular Medicine, College of Medicine, National Cheng Kung University
  • 2010/08~2016/07 Director, Institute of Molecular Medicine, College of Medicine, National Cheng Kung University

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Projects

Research Output

Wwox deficiency leads to neurodevelopmental and degenerative neuropathies and glycogen synthase kinase 3β-mediated epileptic seizure activity in mice

Cheng, Y. Y., Chou, Y. T., Lai, F. J., Jan, M. S., Chang, T. H., Jou, I. M., Chen, P. S., Lo, J. Y., Huang, S. S., Chang, N. S., Liou, Y. T., Hsu, P. C., Cheng, H. C., Lin, Y. S. & Hsu, L. J., 2020 Jan 30, In : Acta Neuropathologica Communications. 8, 1, 6.

Research output: Contribution to journalArticle

Open Access
  • A p53/TIAF1/WWOX triad exerts cancer suppression but may cause brain protein aggregation due to p53/WWOX functional antagonism

    Chou, P. Y., Lin, S. R., Lee, M. H., Schultz, L., Sze, C. I. & Chang, N. S., 2019 Jul 17, In : Cell Communication and Signaling. 17, 1, 76.

    Research output: Contribution to journalArticle

    Open Access
  • 3 Citations (Scopus)

    Editorial: WW Domain Proteins in Signaling, Cancer Growth, Neural Diseases, and Metabolic Disorders

    Chang, N. S., Lin, R., Sze, C. I. & Aqeilan, R. I., 2019 Aug 2, In : Frontiers in Oncology. 9, 719.

    Research output: Contribution to journalEditorial

    Open Access

    Strategies by which WWOX-deficient metastatic cancer cells utilize to survive via dodging, compromising, and causing damage to WWOX-positive normal microenvironment

    Chou, P. Y., Lai, F. J., Chen, Y. A., Sie, Y. D., Kuo, H. L., Su, W. P., Wu, C. Y., Liu, T. Y., Wen, K. Y., Hsu, L. J., Sze, C. I. & Chang, N. S., 2019 Dec 1, In : Cell Death Discovery. 5, 1, 97.

    Research output: Contribution to journalArticle

    Open Access
  • 3 Citations (Scopus)

    WW domain-containing proteins YAP and TAZ in the hippo pathway as key regulators in stemness maintenance, tissue homeostasis, and tumorigenesis

    Chen, Y. A., Lu, C. Y., Cheng, T. Y., Pan, S. H., Chen, H. F. & Chang, N. S., 2019 Jan 1, In : Frontiers in Oncology. 9, FEB, 60.

    Research output: Contribution to journalReview article

    Open Access
  • 14 Citations (Scopus)

    Thesis

    Investigating cancer stem cell sphere explosion via bubbling cell death

    Author: 佩娟, 何., 2018 Aug 29

    Supervisor: Chang, N. (Supervisor)

    Student thesis: Master's Thesis

    Investigating the role of Zfra and ANR40 in cancer suppression

    Author: 彥瑋, 陳., 2017 Aug 29

    Supervisor: Chang, N. (Supervisor)

    Student thesis: Master's Thesis

    Potential role of extracellular vesicles in regulating cancer cell death

    Author: 湘鈴, 郭., 2017 Sep 1

    Supervisor: Chang, N. (Supervisor)

    Student thesis: Master's Thesis