Nan-Shan Chang

Professor

  • 2477 Citations
  • 27 h-Index
1985 …2020
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Research Output 1985 2019

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Article
2019

A p53/TIAF1/WWOX triad exerts cancer suppression but may cause brain protein aggregation due to p53/WWOX functional antagonism

Chou, P. Y., Lin, S. R., Lee, M. H., Schultz, L., Sze, C-I. & Chang, N-S., 2019 Jul 17, In : Cell Communication and Signaling. 17, 1, 76.

Research output: Contribution to journalArticle

Open Access
Brain
Agglomeration
Chemical activation
Apoptosis
Cell Movement
2018

Fast and improved bioimaging via temporal focusing multiphoton excitation microscopy with binary digital-micromirror-device holography

Sie, Y. D., Chang, C-Y., Lin, C. Y., Chang, N-S., Campagnola, P. J. & Chen, S. J., 2018 Jan 1, In : Journal of Biomedical Optics. 23, 11, 116502.

Research output: Contribution to journalArticle

Digital devices
Holography
holography
Microscopic examination
microscopy
1 Citation (Scopus)

Natural zeolite for adsorbing and release of functional materials

Hovhannisyan, V. A., Dong, C. Y., Lai, F. J., Chang, N-S. & Chen, S. J., 2018 Sep 1, In : Journal of Biomedical Optics. 23, 9, 091411.

Research output: Contribution to journalArticle

Zeolites
Functional materials
Spectrometry
Microscopic examination
drugs
2017
7 Citations (Scopus)

Hyaluronan activates Hyal-2/WWOX/Smad4 signaling and causes bubbling cell death when the signaling complex is overexpressed

Hsu, L-J., Hong, Q., Chen, S. T., Kuo, H. L., Schultz, L., Heath, J., Lin, S. R., Lee, M. H., Li, D. Z., Li, Z. L., Cheng, H. C., Armand, G. & Chang, N-S., 2017 Jan 1, In : Oncotarget. 8, 12, p. 19137-19155 19 p.

Research output: Contribution to journalArticle

Hyaluronic Acid
Cell Death
Hyaluronoglucosaminidase
Transforming Growth Factor beta
Membranes
7 Citations (Scopus)
Memory Disorders
Amyloid
Transgenic Mice
Alzheimer Disease
Peptides
2016
10 Citations (Scopus)

Role of WW Domain-Containing oxidoreductase WWOX in driving T cell acute lymphoblastic leukemia maturation

Huang, S. S., Su, W. P., Lin, H. P., Kuo, H. L., Wei, H. L. & Chang, N-S., 2016 Aug 12, In : Journal of Biological Chemistry. 291, 33, p. 17319-17331 13 p.

Research output: Contribution to journalArticle

Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Phosphorylation
T-cells
Ionophores
Calcimycin
2 Citations (Scopus)

Zfra induction of memory anticancer response via a novel immune cell

Su, W. P., Wang, W. J., Sze, C-I. & Chang, N-S., 2016 Sep 1, In : OncoImmunology. 5, 9, e1213935.

Research output: Contribution to journalArticle

Spleen
Heterografts
Tail
Veins
Lymphocytes
2015
3 Citations (Scopus)

Expression of WW domain–Containing oxidoreductase WWOX in pterygium

Huang, Y-H., Chang, N-S. & Tseng, S. H., 2015 Jun 25, In : Molecular Vision. 21, p. 711-717 7 p.

Research output: Contribution to journalArticle

Pterygium
Oxidoreductases
Head
Gene Expression
Body Regions
16 Citations (Scopus)

Fabrication of three-dimensional multi-protein microstructures for cell migration and adhesion enhancement

Da Sie, Y., Li, Y. C., Chang, N-S., Campagnola, P. J. & Chen, S. J., 2015 Jan 1, In : Biomedical Optics Express. 6, 2, p. 480-490 11 p.

Research output: Contribution to journalArticle

Fibronectins
Cell Adhesion
Cell Movement
adhesion
albumins
10 Citations (Scopus)

Introduction to a Thematic Issue for WWOX

Chang, N-S., 2015 Mar 25, In : Experimental Biology and Medicine. 240, 3, p. 281-284 4 p.

Research output: Contribution to journalArticle

Oncogenic viruses
Metabolism
Genes
Tumor Suppressor Proteins
Pathology
3 Citations (Scopus)

Strategies of oncogenic microbes to deal with WW domain-containing oxidoreductase

Chang, Y., Lan, Y. Y., Hsiao, J-R. & Chang, N-S., 2015 Mar 25, In : Experimental Biology and Medicine. 240, 3, p. 329-337 9 p.

Research output: Contribution to journalArticle

Viruses
Oxidoreductases
Cells
Pathogens
Taxation
13 Citations (Scopus)

Trafficking protein particle complex 6A delta (TRAPPC6AΔ) is an extracellular plaque-forming protein in the brain

Chang, J. Y., Lee, M. H., Lin, S. R., Yang, L. Y., Sun, H-F., Sze, C-I., Hong, Q., Lin, Y-S., Chou, Y. T., Hsu, L-J., Jan, M. S., Gong, C. X. & Chang, N-S., 2015 Jan 1, In : Oncotarget. 6, 6, p. 3578-3589 12 p.

Research output: Contribution to journalArticle

Protein Transport
Hippocampus
Down-Regulation
Brain
Alternative Splicing
10 Citations (Scopus)

UV irradiation/cold shock-mediated apoptosis is switched to bubbling cell death at low temperatures

Chen, S. J., Lin, P. W., Lin, H. P., Huang, S. S., Lai, F. J., Sheu, H. M., Hsu, L-J. & Chang, N-S., 2015 Jan 1, In : Oncotarget. 6, 10, p. 8007-8018 12 p.

Research output: Contribution to journalArticle

Shock
Cell Death
TNF Receptor-Associated Factor 2
Apoptosis
Temperature
17 Citations (Scopus)

WWOX suppresses prostate cancer cell progression through cyclin D1-mediated cell cycle arrest in the G1 phase

Lin, J. T., Li, H. Y., Chang, N-S., Lin, C. H., Chen, Y. C. & Lu, P-J., 2015 Feb 1, In : Cell Cycle. 14, 3, p. 408-416 9 p.

Research output: Contribution to journalArticle

Cyclin D1
G1 Phase
Cell Cycle Checkpoints
Prostatic Neoplasms
Neoplasms
7 Citations (Scopus)

Zfra activates memory Hyal-2+ CD3- CD19- spleen cells to block cancer growth, stemness, and metastasis in vivo

Lee, M. H., Su, W. P., Wang, W. J., Lin, S. R., Lu, C. Y., Chen, Y. A., Chang, J. Y., Huang, S. S., Chou, P. Y., Ye, S. R., Chen, S. J., He, H., Liu, T. H., Chou, Y. T., Hsu, L-J., Lai, F. J., Chen, S. J., Lee, H. C., Kakhniashvili, D., Goodman, S. R. & 1 others, Chang, N-S., 2015 Jan 1, In : Oncotarget. 6, 6, p. 3737-3751 15 p.

Research output: Contribution to journalArticle

Spleen
Neoplasm Metastasis
Growth
Neoplasms
Polymerization
2014
20 Citations (Scopus)

Folate deficiency-induced oxidative stress contributes to neuropathy in young and aged zebrafish - Implication in neural tube defects and Alzheimer's diseases

Kao, T. T., Chu, C. Y., Lee, G. H., Hsiao, T. H., Cheng, N. W., Chang, N-S., Chen, B. H. & Fu, T-F., 2014 Jan 1, In : Neurobiology of Disease. 71, 1, p. 234-244 11 p.

Research output: Contribution to journalArticle

Neural Tube Defects
Zebrafish
Folic Acid
Alzheimer Disease
Oxidative Stress
4 Citations (Scopus)

Visualization of subunit interactions and ternary complexes of protein phosphatase 2A in mammalian cells

Shu-Ting, M., Shang-Ju, C., Tai-Yu, L., Yu-Ling, C., Cheng-En, C., Spencer, C. H. K., Kelie, M. R., Yung-Cheng, C., Chang, N-S., Brian, E. W. & Chiang, C-W., 2014 Dec 23, In : PLoS ONE. 9, 12

Research output: Contribution to journalArticle

Ternary Complex Factors
Protein Phosphatase 2
phosphoprotein phosphatase
Visualization
Cells
20 Citations (Scopus)

WW domain-containing oxidoreductase in neuronal injury and neurological diseases

Chang, H. T., Liu, C. C., Chen, S. T., Yap, Y. V., Chang, N-S. & Sze, C-I., 2014 Jan 1, In : Oncotarget. 5, 23, p. 11792-11799 8 p.

Research output: Contribution to journalArticle

Oxidoreductases
Wounds and Injuries
Neoplasms
Genetic Suppression
Gonadal Steroid Hormones
2 Citations (Scopus)

WWOX suppresses KLF5 expression and breast cancer cell growth

Ge, F., Chen, W., Yang, R., Zhou, Z., Chang, N-S., Chen, C., Zou, T., Liu, R., Tan, J. & Ren, G., 2014 Jan 1, In : Chinese Journal of Cancer Research. 26, 5, p. 511-516 6 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Growth
Neoplasms
Cell Proliferation
Cell Line
2013
6 Citations (Scopus)

Expression of WW domain-containing oxidoreductase WOX1 in human nervous system tumors

Chiang, M. F., Chen, S. T., Lo, C. P., Sze, C-I., Chang, N-S. & Chen, Y. J., 2013 Jan 1, In : Analytical Cellular Pathology. 36, 5-6, p. 133-147 15 p.

Research output: Contribution to journalArticle

Neurofibromin 2
Nervous System Neoplasms
Neurofibromatosis 2
Oxidoreductases
Neoplasms
9 Citations (Scopus)

High-throughput fabrication of gray-level biomicrostructures via temporal focusing excitation and laser pulse control

Li, Y. C., Cheng, L. C., Chang, C-Y., Lin, C. Y., Chang, N-S., Campagnola, P. J., Dong, C. Y. & Chen, S. J., 2013 Jul 1, In : Journal of Biomedical Optics. 18, 7, 075004.

Research output: Contribution to journalArticle

Rose Bengal
Bovine Serum Albumin
albumins
serums
Laser pulses
10 Citations (Scopus)

Tumor suppressor WWOX and p53 alterations and drug resistance in glioblastomas

Chiang, M. F., Chou, P. Y., Wang, W. J., Sze, C-I. & Chang, N-S., 2013 Dec 24, In : Frontiers in Oncology. 3 MAR, Article 00043.

Research output: Contribution to journalArticle

temozolomide
Glioblastoma
Drug Resistance
Neoplasms
Genetic Promoter Regions
6 Citations (Scopus)

WW domain-containing oxidoreductase is involved in upregulation of matrix metalloproteinase 9 by Epstein-Barr virus latent membrane protein 2A

Lan, Y. Y., Wu, S. Y., Lai, H. C., Chang, N-S., Chang, F. H., Tsai, M. H., Su, I. J. & Chang, Y., 2013 Jul 12, In : Biochemical and Biophysical Research Communications. 436, 4, p. 672-676 5 p.

Research output: Contribution to journalArticle

Matrix Metalloproteinase 9
Human Herpesvirus 4
Viruses
Oxidoreductases
Membrane Proteins
21 Citations (Scopus)

WWOX suppresses autophagy for inducing apoptosis in methotrexate-treated human squamous cell carcinoma

Tsai, C. W., Lai, F. J., Sheu, H. M., Lin, Y-S., Chang, T. H., Jan, M. S., Chen, S. M., Hsu, P. C., Huang, T. T., Huang, T. C., Sheen, M. C., Chen, S. T., Chang, W. C., Chang, N-S. & Hsu, L-J., 2013 Sep 1, In : Cell Death and Disease. 4, 9, e792.

Research output: Contribution to journalArticle

Autophagy
Methotrexate
Squamous Cell Carcinoma
Apoptosis
Sirolimus
2012
15 Citations (Scopus)

Investigation of two-photon excited fluorescence increment via crosslinked bovine serum albumin

Lin, C. Y., Lien, C. H., Cho, K. C., Chang, C-Y., Chang, N-S., Campagnola, P. J., Dong, C. Y. & Chen, S. J., 2012 Jun 18, In : Optics Express. 20, 13, p. 13669-13676 8 p.

Research output: Contribution to journalArticle

albumins
serums
fluorescence
decay rates
photons
16 Citations (Scopus)

Overexpression of WW domain-containing oxidoreductase WOX1 preferentially induces apoptosis in human glioblastoma cells harboring mutant p53

Chiang, M. F., Yeh, S. T., Liao, H. F., Chang, N-S. & Chen, Y. J., 2012 Sep 1, In : Biomedicine and Pharmacotherapy. 66, 6, p. 433-438 6 p.

Research output: Contribution to journalArticle

Glioblastoma
Oxidoreductases
Apoptosis
temozolomide
DNA Fragmentation
15 Citations (Scopus)

Prc contributes to Escherichia coli evasion of classical complement-mediated serum killing

Wang, C. Y., Wang, S-W., Huang, W. C., Kim, K. S., Chang, N-S., Wang, Y. H., Wu, M-H. & Teng, C-H., 2012 Oct 1, In : Infection and Immunity. 80, 10, p. 3399-3409 11 p.

Research output: Contribution to journalArticle

Bacteremia
Escherichia coli
Serum
Gram-Negative Bacterial Infections
Complement Membrane Attack Complex
60 Citations (Scopus)

Spatiotemporal focusing-based widefield multiphoton microscopy for fast optical sectioning

Cheng, L. C., Chang, C-Y., Lin, C. Y., Cho, K. C., Yen, W. C., Chang, N-S., Xu, C., Dong, C. Y. & Chen, S. J., 2012 Apr 9, In : Optics Express. 20, 8, p. 8939-8948 10 p.

Research output: Contribution to journalArticle

microscopes
microscopy
tendons
chickens
excitation
15 Citations (Scopus)

TIAF1 self-aggregation in peritumor capsule formation, spontaneous activation of SMAD-responsive promoter in p53-deficient environment, and cell death

Chang, J. Y., Chiang, M. F., Lin, S. R., Lee, M. H., He, H., Chou, P. Y., Chen, S. J., Chen, Y. A., Yang, L. Y., Lai, F. J., Hsieh, C. C., Hsieh, T. H., Sheu, H. M., Sze, C-I. & Chang, N-S., 2012 Apr 1, In : Cell Death and Disease. 3, 4, e302.

Research output: Contribution to journalArticle

Capsules
Cell Death
Neoplasms
Transforming Growth Factors
Neuroblastoma
22 Citations (Scopus)

WW domain-containing oxidoreductase promotes neuronal differentiation via negative regulation of glycogen synthase kinase 3Β

Wang, H. Y., Juo, L. I., Lin, Y. T., Hsiao, M., Lin, J. T., Tsai, C. H., Tzeng, Y. H., Chuang, Y. C., Chang, N-S., Yang, C. N. & Lu, P-J., 2012 Jun 1, In : Cell Death and Differentiation. 19, 6, p. 1049-1059 11 p.

Research output: Contribution to journalArticle

Glycogen Synthase Kinase 3
Oxidoreductases
Microtubules
Tretinoin
Microtubule-Associated Proteins
2011
21 Citations (Scopus)

Identification of an in vivo MEK/WOX1 complex as a master switch for apoptosis in t cell leukemia

Lin, H. P., Chang, J. Y., Lin, S. R., Lee, M. H., Huang, S. S., Hsu, L-J. & Chang, N-S., 2011 May 1, In : Genes and Cancer. 2, 5, p. 550-562 13 p.

Research output: Contribution to journalArticle

Mitogen-Activated Protein Kinase Kinases
Leukemia
Tetradecanoylphorbol Acetate
Apoptosis
Jurkat Cells
20 Citations (Scopus)

Solanum incanum extract (SR-T100) induces human cutaneous squamous cell carcinoma apoptosis through modulating tumor necrosis factor receptor signaling pathway

Wu, C. H., Liang, C. H., Shiu, L. Y., Chang, L. C., Lin, T. S., Lan, C. C. E., Tsai, J-C., Wong, T-W., Wei, K. J., Lin, T. K., Chang, N-S. & Sheu, H. M., 2011 Aug 1, In : Journal of Dermatological Science. 63, 2, p. 83-92 10 p.

Research output: Contribution to journalArticle

Solanum
Tumor Necrosis Factor Receptors
Squamous Cell Carcinoma
Apoptosis
Skin
2010
22 Citations (Scopus)

Imaging live cell membranes via surface plasmon-enhanced fluorescence and phase microscopy

He, R. Y., Lin, C. Y., Su, Y. D., Chiu, K. C., Chang, N-S., Wu, H-L. & Chen, S. J., 2010 Feb 15, In : Optics Express. 18, 4, p. 3649-3659 11 p.

Research output: Contribution to journalArticle

microscopy
fluorescence
microscopes
sensitivity
numerical aperture
13 Citations (Scopus)

Study of cell-biosubstrate contacts via surface plasmon polariton phase microscopy

Su, Y. D., Chiu, K. C., Chang, N-S., Wu, H-L. & Chen, S. J., 2010 Sep 13, In : Optics Express. 18, 19, p. 20125-20135 11 p.

Research output: Contribution to journalArticle

polaritons
microscopy
cells
surface plasmon resonance
apoptosis
30 Citations (Scopus)

TGF-β induces TIAF1 self-aggregation via type II receptor-independent signaling that leads to generation of amyloid β plaques in Alzheimer's disease

Lee, M. H., Lin, S. R., Chang, J. Y., Schultz, L., Heath, J., Hsu, L-J., Kuo, Y-M., Hong, Q., Chiang, M. F., Gong, C. X., Sze, C-I. & Chang, N-S., 2010 Dec 1, In : Cell Death and Disease. 1, 12, e110.

Research output: Contribution to journalArticle

Amyloid Plaques
Amyloid
Transforming Growth Factor beta
Alzheimer Disease
Smad Proteins
7 Citations (Scopus)

Zfra is a small wizard in the mitochondrial apoptosis

Dudekula, S., Lee, M. H., Hsu, L-J., Chen, S. J. & Chang, N-S., 2010 Jan 1, In : Aging. 2, 12, p. 1023-1029 7 p.

Research output: Contribution to journalArticle

Apoptosis
Cytochromes c
Cell Death
Tumor Necrosis Factor-alpha
Proteins
2009
57 Citations (Scopus)

Complement C1q activates tumor suppressor WWOX to induce apoptosis in prostate cancer cells

Hong, Q., Sze, C-I., Lin, S. R., Lee, M. H., He, R. Y., Schultz, L., Chang, J. Y., Chen, S. J., Boackle, R. J., Hsu, L-J. & Chang, N-S., 2009 Jun 1, In : PloS one. 4, 6, e5755.

Research output: Contribution to journalArticle

Complement C1q
prostatic neoplasms
Tumors
Prostatic Neoplasms
complement
33 Citations (Scopus)

Dramatic co-activation of WWOX/WOX1 with CREB and NF-κB in delayed loss of small dorsal root ganglion neurons upon sciatic nerve transection in rats

Li, M. Y., Lai, F. J., Hsu, L-J., Lo, C. P., Cheng, C. L., Lin, S. R., Lee, M. H., Chang, J. Y., Subhan, D., Tsai, M. S., Sze, C-I., Pugazhenthi, S., Chang, N-S. & Chen, S. T., 2009 Nov 12, In : PloS one. 4, 11, e7820.

Research output: Contribution to journalArticle

Spinal Ganglia
Sciatic Nerve
Neurons
Rats
nerve tissue
38 Citations (Scopus)

Surface plasmon-enhanced two-photon fluorescence microscopy for live cell membrane imaging

He, R. Y., Su, Y. D., Cho, K. C., Lin, C. Y., Chang, N-S., Chang, C-H. & Chen, S. J., 2009 Apr 13, In : Optics Express. 17, 8, p. 5987-5997 11 p.

Research output: Contribution to journalArticle

microscopy
fluorescence
photons
microscopes
plasmons
44 Citations (Scopus)

Transforming growth factor β1 signaling via interaction with cell surface hyal-2 and recruitment of WWOX/WOX1

Hsu, L-J., Schultz, L., Hong, Q., Van Moer, K., Heath, J., Li, M. Y., Lai, F. J., Lin, S. R., Lee, M. H., Lo, C. P., Lin, Y-S., Chen, S. T. & Chang, N-S., 2009 Jun 5, In : Journal of Biological Chemistry. 284, 23, p. 16049-16059 11 p.

Research output: Contribution to journalArticle

Transforming Growth Factors
Cell Communication
Chemical activation
Cell death
Cell Death
2008
22 Citations (Scopus)

MPP+-induced neuronal death in rats involves tyrosine 33 phosphorylation of WW domain-containing oxidoreductase WOX1

Lo, C. P., Hsu, L-J., Li, M. Y., Hsu, S. Y., Chuang, J-I., Tsai, M. S., Lin, S. R., Chang, N-S. & Chen, S. T., 2008 Apr 1, In : European Journal of Neuroscience. 27, 7, p. 1634-1646 13 p.

Research output: Contribution to journalArticle

Tyrosine
Oxidoreductases
Phosphorylation
Peptides
Parkinson Disease
13 Citations (Scopus)

Zfra is an inhibitor of Bcl-2 expression and cytochrome c release from the mitochondria

Hsu, L-J., Hong, Q., Schultz, L., Kuo, E., Lin, S. R., Lee, M. H., Lin, Y-S. & Chang, N-S., 2008 Jul 1, In : Cellular Signalling. 20, 7, p. 1303-1312 10 p.

Research output: Contribution to journalArticle

Cytochromes c
Mitochondria
Mitochondrial Membrane Potential
Cell Death
TNF Receptor-Associated Death Domain Protein
2007
6 Citations (Scopus)
Classical Complement Pathway
Hyaluronic Acid
Prostate
Complement System Proteins
Cell Surface Receptors
85 Citations (Scopus)

WW domain-containing oxidoreductase: a candidate tumor suppressor

Chang, N-S., Hsu, L-J., Lin, Y-S., Lai, F. J. & Sheu, H. M., 2007 Jan 1, In : Trends in Molecular Medicine. 13, 1, p. 12-22 11 p.

Research output: Contribution to journalArticle

Oxidoreductases
Neoplasms
Hyaluronoglucosaminidase
Gonadal Steroid Hormones
Androgens
34 Citations (Scopus)
TNF Receptor-Associated Death Domain Protein
Mitogen-Activated Protein Kinase 8
Cell death
Cell Death
Tumor Necrosis Factor-alpha
2005
61 Citations (Scopus)
Androgen Receptors
Prostate
Estradiol
Breast
Up-Regulation
10 Citations (Scopus)
TNF Receptor-Associated Death Domain Protein
Cloning
Zinc Fingers
Ultraviolet Rays
Gene Library
40 Citations (Scopus)
Tyrosine
Retina
Oxidoreductases
Phosphorylation
Light
85 Citations (Scopus)
Phosphorylation
Staurosporine
Cell death
Ultraviolet Rays
Ultraviolet radiation
43 Citations (Scopus)

WOX1 is essential for UVB irradiation-induced apoptosis and down-regulated via translational blockade in UVB-induced cutaneous squamous cell carcinoma in vivo

Lai, F. J., Cheng, C. L., Chen, S. T., Wu, C. H., Hsu, L-J., Lee, Y-Y., Chao, S-C., Sheen, M. C., Shen, C. L., Chang, N-S. & Sheu, H. M., 2005 Aug 15, In : Clinical Cancer Research. 11, 16, p. 5769-5777 9 p.

Research output: Contribution to journalArticle

Squamous Cell Carcinoma
Apoptosis
Skin
Phosphorylation
Keratinocytes