• 7059 Citations
  • 43 h-Index
1990 …2020

Research output per year

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Research Output

  • 7059 Citations
  • 43 h-Index
  • 167 Article
  • 2 Review article
  • 1 Comment/debate
2019

High-CLDN4 ESCC cells harbor stem-like properties and indicate for poor concurrent chemoradiation therapy response in esophageal squamous cell carcinoma

Lin, C. H., Li, H. Y., Liu, Y. P., Kuo, P. F., Wang, W. C., Lin, F. C., Chang, W. L., Sheu, B. S., Wang, Y. C., Hung, W. C., Cheng, H. C., Yao, Y. C., Calkins, M. J., Hsiao, M. & Lu, P. J., 2019 Jan 1, In : Therapeutic Advances in Medical Oncology. 11

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Therapeutic targeting of aldolase a interactions inhibits lung cancer metastasis and prolongs survival

Chang, Y. C., Chiou, J., Yang, Y. F., Su, C. Y., Lin, Y. F., Yang, C. N., Lu, P. J., Huang, M. S., Yang, C. J. & Hsiao, M., 2019 Sep 15, In : Cancer Research. 79, 18, p. 4754-4766 13 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2018

A novel long non-coding RNA linc-ZNF469-3 promotes lung metastasis through miR-574-5p-ZEB1 axis in triple negative breast cancer

Wang, P. S., Chou, C. H., Lin, C. H., Yao, Y. C., Cheng, H. C., Li, H. Y., Chuang, Y. C., Yang, C. N., Ger, L. P., Chen, Y. C., Lin, F. C., Shen, T. L., Hsiao, M. & Lu, P. J., 2018 Aug 23, In : Oncogene. 37, 34, p. 4662-4678 17 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)
4 Citations (Scopus)
2017
7 Citations (Scopus)

CTMP, a predictive biomarker for trastuzumab resistance in HER2-enriched breast cancer patient

Chen, Y. C., Li, H. Y., Liang, J. L., Ger, L. P., Chang, H. T., Hsiao, M., Calkins, M. J., Cheng, H. C., Chuang, J. H. & Lu, P. J., 2017, In : Oncotarget. 8, 18, p. 29699-29710 12 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Fructose induced neurogenic hypertension mediated by overactivation of p38 MAPK to impair insulin signaling transduction caused central insulin resistance

Cheng, P. W., Lin, Y. T., Ho, W. Y., Lu, P. J., Chen, H. H., Lai, C. C., Sun, G. C., Yeh, T. C., Hsiao, M., Tseng, C. J. & Liu, C. P., 2017 Nov, In : Free Radical Biology and Medicine. 112, p. 298-307 10 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

miR-105/93-3p promotes chemoresistance and circulating miR-105/93-3p acts as a diagnostic biomarker for triple negative breast cancer

Li, H. Y., Liang, J. L., Kuo, Y. L., Lee, H. H., Calkins, M. J., Chang, H. T., Lin, F. C., Chen, Y. C., Hsu, T. I., Hsiao, M., Ger, L. P. & Lu, P. J., 2017 Dec 19, In : Breast Cancer Research. 19, 1, 133.

Research output: Contribution to journalArticle

33 Citations (Scopus)

Phosphorylation of Rab37 by protein kinase C alpha inhibits the exocytosis function and metastasis suppression activity of Rab37

Tzeng, H. T., Li, T. H., Tang, Y. A., Tsai, C. H., Lu, P. J. F., Lai, W. W., Chiang, C. W. & Wang, Y. C., 2017 Jan 1, In : Oncotarget. 8, 65, p. 108556-108570 15 p.

Research output: Contribution to journalArticle

TGFβ promotes mesenchymal phenotype of pancreatic cancer cells, in part, through epigenetic activation of VAV1

Huang, P. H., Lu, P. J., Ding, L. Y., Chu, P. C., Hsu, W. Y., Chen, C. S., Tsao, C. C., Chen, B. H., Lee, C. T., Shan, Y. S. & Chen, C. S., 2017 Apr 20, In : Oncogene. 36, 16, p. 2202-2214 13 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)
2016

Grb7 protein stability modulated by pin1 in association with cell cycle progression

Tai, Y. L., Tung, L. H., Lin, Y. C., Lu, P. J., Chu, P. Y., Wang, M. Y., Huang, W. P., Chen, K. C., Lee, H. & Shen, T. L., 2016 Sep, In : PloS one. 11, 9, e0163617.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Huntingtin-interacting protein-1 is an early-stage prognostic biomarker of lung adenocarcinoma and suppresses metastasis via AKT-mediated epithelial-mesenchymal transition

Hsu, C. Y., Lin, C. H., Jan, Y. H., Su, C. Y., Yao, Y. C., Cheng, H. C., Hsu, T. I., Wang, P. S., Su, W. P., Yang, C. J., Huang, M. S., Calkins, M. J., Hsiao, M. & Lu, P. J., 2016 Apr 15, In : American Journal of Respiratory and Critical Care Medicine. 193, 8, p. 869-880 12 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

MiR-193a-5p/ERBB2 act as concurrent chemoradiation therapy response indicator of esophageal squamous cell carcinoma

Lin, C. H., Tsai, C. H., Yeh, C. T., Liang, J. L., Hung, W. C., Lin, F. C., Chang, W. L., Li, H. Y., Yao, Y. C., Hsu, T. I., Lee, Y. C., Wang, Y. C., Sheu, B. S., Lai, W. W., Calkins, M. J., Hsiao, M. & Lu, P. J., 2016, In : Oncotarget. 7, 26, p. 39680-39693 14 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)
6 Citations (Scopus)

Paricalcitol Attenuates Cardiac Fibrosis and Expression of Endothelial Cell Transition Markers in Isoproterenol-Induced Cardiomyopathic Rats

Lai, C. C., Liu, C. P., Cheng, P. W., Lu, P. J., Hsiao, M., Lu, W. H., Sun, G. C., Liou, J. C. & Tseng, C. J., 2016 Sep 1, In : Critical care medicine. 44, 9, p. e866-e874

Research output: Contribution to journalArticle

4 Citations (Scopus)

Renal Denervation Improves the Baroreflex and GABA System in Chronic Kidney Disease-induced Hypertension

Chen, H. H., Cheng, P. W., Ho, W. Y., Lu, P. J., Lai, C. C., Tseng, Y. M., Fang, H. C., Sun, G. C., Hsiao, M., Liu, C. P. & Tseng, C. J., 2016 Dec 5, In : Scientific reports. 6, 38447.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Resveratrol Inhibition of Rac1-Derived Reactive Oxygen Species by AMPK Decreases Blood Pressure in a Fructose-Induced Rat Model of Hypertension

Cheng, P. W., Lee, H. C., Lu, P. J., Chen, H. H., Lai, C. C., Sun, G. C., Yeh, T. C., Hsiao, M., Lin, Y. T., Liu, C. P. & Tseng, C. J., 2016 May 3, In : Scientific reports. 6, 25342.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Suppressive function of low-dose deguelin on the invasion of oral cancer cells by downregulating tumor necrosis factor alpha-induced nuclear factor-kappa B signaling

Liu, Y. P., Lee, J. J., Lai, T. C., Lee, C. H., Hsiao, Y. W., Chen, P. S., Liu, W. T., Hong, C. Y., Lin, S. K., Ping Kuo, M. Y., Lu, P. J. & Hsiao, M., 2016 Apr 1, In : Head and Neck. 38, p. E524-E534

Research output: Contribution to journalArticle

18 Citations (Scopus)
2015

GIT1 promotes lung cancer cell metastasis through modulating Rac1/Cdc42 activity and is associated with poor prognosis

Chang, J. S., Su, C. Y., Yu, W. H., Lee, W. J., Liu, Y. P., Lai, T. C., Jan, Y. H., Yang, Y. F., Shen, C. N., Shew, J. Y., Lu, J., Yang, C. J., Huang, M. S., Lu, P. J., Lin, Y. F., Kuo, M. L., Hua, K. T. & Hsiao, M., 2015 Jan 1, In : Oncotarget. 6, 34, p. 36278-36291 14 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

GPCR dimerization in brainstem nuclei contributes to the development of hypertension

Sun, G. C., Ho, W. Y., Chen, B. R., Cheng, P. W., Cheng, W. H., Hsu, M. C., Yeh, T. C., Hsiao, M., Lu, P. J. & Tseng, C. J., 2015 May 1, In : British Journal of Pharmacology. 172, 10, p. 2507-2518 12 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Heme oxygenase-1 ameliorates kidney ischemia-reperfusion injury in mice through extracellular signal-regulated kinase 1/2-enhanced tubular epithelium proliferation

Chen, H. H., Lu, P. J., Chen, B. R., Hsiao, M., Ho, W. Y. & Tseng, C. J., 2015 Oct 1, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1852, 10, p. 2195-2201 7 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Landscape of Pin1 in the cell cycle

Lin, C. H., Li, H. Y., Lee, Y. C., Calkins, M. J., Lee, K. H., Yang, C. N. & Lu, P. J., 2015 Mar 25, In : Experimental Biology and Medicine. 240, 3, p. 403-408 6 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

Loss of Egr-1 sensitizes pancreatic β-cells to palmitate-induced ER stress and apoptosis

Cheong, M. W., Kuo, L. H., Cheng, Y. N., Tsai, P-J., Ho, L. C., Tai, H. C., Chiu, W-T., Chen, S., Lu, P-J., Shan, Y-S., Chuang, L. M. & Tsai, Y-S., 2015 Jul 22, In : Journal of Molecular Medicine. 93, 7, p. 807-818 12 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Plasminogen activator inhibitor-2 plays a leading prognostic role among protease families in non-small cell lung cancer

Su, C. Y., Liu, Y. P., Yang, C. J., Lin, Y. F., Chiou, J., Chi, L. H., Lee, J. J., Wu, A. T. H., Lu, P. J., Huang, M. S. & Hsiao, M., 2015 Jul 31, In : PloS one. 10, 7, e0133411.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Wnt Signaling Regulates Blood Pressure by Downregulating a GSK-3β-Mediated Pathway to Enhance Insulin Signaling in the Central Nervous System

Cheng, P. W., Chen, Y. Y., Cheng, W. H., Lu, P. J., Chen, H. H., Chen, B. R., Yeh, T. C., Sun, G. C., Hsiao, M. & Tseng, C. J., 2015 Oct 1, In : Diabetes. 64, 10, p. 3413-3424 12 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

WWOX suppresses prostate cancer cell progression through cyclin D1-mediated cell cycle arrest in the G1 phase

Lin, J. T., Li, H. Y., Chang, N-S., Lin, C. H., Chen, Y. C. & Lu, P-J., 2015 Feb 1, In : Cell Cycle. 14, 3, p. 408-416 9 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)
2014

Anti-apoptotic effects of osteopontin through the up-regulation of Mcl-1 in gastrointestinal stromal tumors

Hsu, K. H., Tsai, H. W., Lin, P. W., Hsu, Y. S., Lu, P. J. & Shan, Y. S., 2014 Jun 20, In : World Journal of Surgical Oncology. 12, 1, 189.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Caffeine intake improves fructose-induced hypertension and insulin resistance by enhancing central insulin signaling

Yeh, T. C., Liu, C. P., Cheng, W. H., Chen, B. R., Lu, P. J., Cheng, P. W., Ho, W. Y., Sun, G. C., Liou, J. C. & Tseng, C. J., 2014 Mar 1, In : Hypertension. 63, 3, p. 535-541 7 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Different impacts of α-and β-blockers in neurogenic hypertension produced by brainstem lesions in rat

Lu, W. H., Hsieh, K. S., Lu, P. J., Wu, Y. S., Ho, W. Y., Cheng, P. W., Lai, C. C., Hsiao, M. & Tseng, C. J., 2014 May, In : Anesthesiology. 120, 5, p. 1192-1204 13 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Involvement of two distinct signalling pathways in IGF-1-mediated central control of hypotensive effects in normotensive and hypertensive rats

Cheng, P. W., Kang, B. H., Lu, P. J., Lin, S. S., Ho, W. Y., Chen, H. H., Hong, L. Z., Wu, Y. S., Hsiao, M. & Tseng, C. J., 2014 Sep, In : Acta Physiologica. 212, 1, p. 28-38 11 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Low SOX17 expression is a prognostic factor and drives transcriptional dysregulation and esophageal cancer progression

Kuo, I. Y., Wu, C. C., Chang, J. M., Huang, Y. L., Lin, C. H., Yan, J. J., Sheu, B. S., Lu, P. J., Chang, W. L., Lai, W. W. & Wang, Y. C., 2014 Aug 1, In : International Journal of Cancer. 135, 3, p. 563-573 11 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)

MicroRNA-18a is elevated in prostate cancer and promotes tumorigenesis through suppressing STK4 in vitro and in vivo

Hsu, T. I., Hsu, C. H., Lee, K. H., Lin, J. T., Chen, C. S., Chang, K. C., Su, C. Y. J., Hsiao, M. & Lu, P. J., 2014 Jan 1, In : Oncogenesis. 3, 4, e99.

Research output: Contribution to journalArticle

52 Citations (Scopus)

MicroRNA-296-5p (miR-296-5p) functions as a tumor suppressor in prostate cancer by directly targeting Pin1

Lee, K. H., Lin, F. C., Hsu, T. I., Lin, J. T., Guo, J. H., Tsai, C. H., Lee, Y. C., Lee, Y. C., Chen, C. L., Hsiao, M. & Lu, P. J., 2014 Sep, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1843, 9, p. 2055-2066 12 p.

Research output: Contribution to journalArticle

67 Citations (Scopus)

Pin1-mediated Sp1 phosphorylation by CDK1 increases Sp1 stability and decreases its DNA-binding activity during mitosis

Yang, H. C., Chuang, J. Y., Jeng, W. Y., Liu, C. I., Wang, A. H. J., Lu, P. J., Chang, W. C. & Hung, J. J., 2014 Dec 16, In : Nucleic acids research. 42, 22, p. 13573-13587 15 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Pin1 positively affects tumorigenesis of esophageal squamous cell carcinoma and correlates with poor survival of patients

Lin, F. C., Lee, Y. C., Goan, Y. G., Tsai, C. H., Yao, Y. C., Cheng, H. C., Lai, W. W., Wang, Y. C., Sheu, B. S. & Lu, P. J., 2014 Aug 27, In : Journal of biomedical science. 21, 1, 21.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Prognostic CpG methylation biomarkers identified by methylation array in esophageal squamous cell carcinoma patients

Kuo, I. Y., Chang, J. M., Jiang, S. S., Chen, C. H., Chang, I. S., Sheu, B. S., Lu, P. J., Chang, W. L., Lai, W. W. & Wang, Y. C., 2014 May 30, In : International Journal of Medical Sciences. 11, 8, p. 779-787 9 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Resveratrol decreases fructose-induced oxidative stress, mediated by NADPH oxidase via an AMPK-dependent mechanism

Cheng, P. W., Ho, W. Y., Su, Y. T., Lu, P. J., Chen, B. Z., Cheng, W. H., Lu, W. H., Sun, G. C., Yeh, T. C., Hsiao, M. & Tseng, C. J., 2014 Jun, In : British Journal of Pharmacology. 171, 11, p. 2739-2750 12 p.

Research output: Contribution to journalArticle

56 Citations (Scopus)

Squalene synthase induces tumor necrosis factor receptor 1 enrichment in lipid rafts to promote lung cancer metastasis

Yang, Y. F., Jan, Y. H., Liu, Y. P., Yang, C. J., Su, C. Y., Chang, Y. C., Lai, T. C., Chiou, J., Tsai, H. Y., Lu, J., Shen, C. N., Shew, J. Y., Lu, P. J., Lin, Y. F., Huang, M. S. & Hsiao, M., 2014 Sep 15, In : American Journal of Respiratory and Critical Care Medicine. 190, 6, p. 675-687 13 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Synthesis and antiproliferative evaluation of 9-methoxy-6-(piperazin-1-yl)- 11H-indeno[1,2-c]quinoline-11-one derivatives. Part 4

Tseng, C. H., Tzeng, C. C., Chiu, C. C., Yang, C. L., Lu, P. J., Chou, C. K., Liu, C. Y. & Chen, Y. L., 2014 Jul, In : MedChemComm. 5, 7, p. 937-948 12 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Synthesis of (E)-5-methoxy-2-styryl-4-pyrones as potent growth-inhibitory agents against hepatocellular carcinoma cells

Chen, Y. H., Lu, P-J., Hulme, C. & Shaw, A. Y., 2014 Jan 1, In : Journal of Heterocyclic Chemistry. 51, 1, p. 56-61 6 p.

Research output: Contribution to journalArticle

2013

Analysis of protein-protein interactions in cross-talk pathways reveals CRKL protein as a novel prognostic marker in hepatocellular carcinoma

Liu, C. H., Chen, T. C., Chau, G. Y., Jan, Y. H., Chen, C. H., Hsu, C. N., Lin, K. T., Juang, Y. L., Lu, P. J., Cheng, H. C., Chen, M. H., Chang, C. F., Ting, Y. S., Kao, C. Y., Hsiao, M. & Huang, C. Y. F., 2013 May 1, In : Molecular and Cellular Proteomics. 12, 5, p. 1335-1349 15 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Carboxyl-terminal modulator protein positively regulates Akt phosphorylation and acts as an oncogenic driver in breast cancer

Liu, Y. P., Liao, W. C., Ger, L. P., Chen, J. C., Hsu, T. I., Lee, Y. C., Chang, H. T., Chen, Y. C., Jan, Y. H., Lee, K. H., Zeng, Y. H., Hsiao, M. & Lu, P. J., 2013 Oct 15, In : Cancer Research. 73, 20, p. 6194-6205 12 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Cisplatin selects for multidrug-resistant CD133+ cells in lung adenocarcinoma by activating notch signaling

Liu, Y. P., Yang, C. J., Huang, M. S., Yeh, C. T., Wu, A. T. H., Lee, Y. C., Lai, T. C., Lee, C. H., Hsiao, Y. W., Lu, J., Shen, C. N., Lu, P. J. & Hsiao, M., 2013 Jan 1, In : Cancer Research. 73, 1, p. 406-416 11 p.

Research output: Contribution to journalArticle

126 Citations (Scopus)

Design, synthesis, biological evaluation and molecular modeling studies of 1-aryl-6-(3,4,5-trimethoxyphenyl)-3(Z)-hexen-1,5-diynes as a new class of potent antitumor agents

Lo, Y. H., Lin, Y. T., Liu, Y. P., Duh, T. H., Lu, P. J. & Wu, M. J., 2013 Apr 1, In : European Journal of Medicinal Chemistry. 62, p. 526-533 8 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Discovery of indeno[1,2-c ]quinoline derivatives as dual topoisomerases I/II inhibitors: Part 3

Tseng, C. H., Tzeng, C. C., Yang, C. L., Lu, P. J., Liu, Y. P., Chen, H. L., Chen, C. Y., Yang, C. N. & Chen, Y. L., 2013 Nov 1, In : Molecular Diversity. 17, 4, p. 781-799 19 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Dissecting the EGFR-PI3K-AKT pathway in oral cancer highlights the role of the EGFR variant III and its clinical relevance

Chang, K. Y., Tsai, S. Y., Chen, S. H., Tsou, H. H., Yen, C. J., Liu, K. J., Fang, H. L., Wu, H. C., Chuang, B. F., Chou, S. W., Tang, C. K., Liu, S. Y., Lu, P. J., Yen, C. Y. & Chang, J. Y., 2013 Jul 2, In : Journal of biomedical science. 20, 1, 43.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Endoplasmic reticulum ribosome-binding protein 1 (RRBP1) overexpression is frequently found in lung cancer patients and alleviates intracellular stress-induced apoptosis through the enhancement of GRP78

Tsai, H. Y., Yang, Y. F., Wu, A. T., Yang, C. J., Liu, Y. P., Jan, Y. H., Lee, C. H., Hsiao, Y. W., Yeh, C. T., Shen, C. N., Lu, P. J., Huang, M. S. & Hsiao, M., 2013 Oct 10, In : Oncogene. 32, 41, p. 4921-4931 11 p.

Research output: Contribution to journalArticle

41 Citations (Scopus)

Glycogen synthase kinase 3 β activity is required for hBora/Aurora A-mediated mitotic entry

Lee, Y. C., Liao, P. C., Liou, Y. C., Hsiao, M., Huang, C. Y. & Lu, P. J., 2013 Mar 15, In : Cell Cycle. 12, 6, p. 953-960 8 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Hexamethonium reverses the lethal cardiopulmonary damages in a rat model of brainstem lesions mimicking fatal enterovirus 71 encephalitis

Lu, W. H., Hsieh, K. S., Lu, P-J., Wu, Y. S., Ho, W. Y., Lai, C. C., Wang, J. S., Ger, L. P., Hsiao, M. & Tseng, C. J., 2013 May 1, In : Critical Care Medicine. 41, 5, p. 1276-1285 10 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

High expression of CHRNA1 is associated with reduced survival in early stage lung adenocarcinoma after complete resection

Chang, P. M. H., Yeh, Y. C., Chen, T. C., Wu, Y. C., Lu, P. J., Cheng, H. C., Lu, H. J., Chen, M. H., Chou, T. Y. & Huang, C. Y. F., 2013 Oct 1, In : Annals of Surgical Oncology. 20, 11, p. 3648-3654 7 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)