Peng-Chieh Chen

2024

Cytoplasmic Lipid Droplets Predict Worse Prognosis in Diffuse Large B-Cell Lymphoma: Next-Generation Sequencing Deciphering Lipogenic Genes

Wang, S. H., Chiang, P. M., Su, Y. Y., Yu, Y. T., Chen, Y. P., Chen, T. Y., Medeiros, L. J., Chu, C. Y., Chen, P. C. & Chang, K. C., 2024 Nov 1, In: American Journal of Surgical Pathology. 48, 11, p. 1425-1438 14 p.

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Dominant dystrophic epidermolysis bullosa is associated with glycolytically active GATA3⁺T helper 2 cells which may contribute to pruritus in lesional skin

Aala, W. J. F., Hou, P. C., Hong, Y. K., Lin, Y. C., Lee, Y. R., Tu, W. T., Papanikolaou, M., Benzian-Olsson, N., Onoufriadis, A., Harn, H. I. C., Hwang, D. Y., Cheng, S. M., Lu, K., Chen, P. C., Mcgrath, J. A. & Hsu, C. K., 2024 Aug, In: British Journal of Dermatology. 191, 2, p. 252-260 9 p.

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Homozygous variant in translocase of outer mitochondrial membrane 7 leads to metabolic reprogramming and microcephalic osteodysplastic dwarfism with moyamoya disease

Li, C. Y., Chen, L. W., Tsai, M. C., Chou, Y. Y., Lin, P. X., Chang, Y. M., Hwu, W. L., Chien, Y. H., Lin, J. L., Chen, H. A., Lee, N. C., Su, P. H., Hsieh, T. C., Klinkhammer, H., Wang, Y. C., Huang, Y. T., Krawitz, P. M., Lin, S. H., Huang, L. L. H., Chiang, P. M., & 2 othersShih, M. H. & Chen, P. C., 2024 Dec, In: EBioMedicine. 110, 105476.

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Profibrotic Subsets of SPP1⁺ Macrophages and POSTN⁺ Fibroblasts Contribute to Fibrotic Scarring in Acne Keloidalis

Hong, Y. K., Hwang, D. Y., Yang, C. C., Cheng, S. M., Chen, P. C., Aala, W. J., I-Chen Harn, H., Evans, S. T., Onoufriadis, A., Liu, S. L., Lin, Y. C., Chang, Y. H., Lo, T. K., Hung, K. S., Lee, Y. C., Tang, M. J., Lu, K. Q., McGrath, J. A. & Hsu, C. K., 2024 Jul, In: Journal of Investigative Dermatology. 144, 7, p. 1491-1504.e10

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Syndromic ciliopathy: a taiwanese single-center study

Pan, Y. W., Ou, T. Y., Chou, Y. Y., Kuo, P. L., Hsiao, H. P., Chiu, P. C., Lin, J. L., Lo, F. S., Wang, C. H., Chen, P. C. & Tsai, M. C., 2024 Dec, In: BMC Medical Genomics. 17, 1, 106.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Citations (Scopus)

2023

Novel SLC5A6 mutations lead to B lymphocyte maturation defects with metabolic abnormality rescuable by biotin replenishment

Hsieh, C. H., Lee, J., Sung, H. H., Huang, Y. F., Ding, Y. S., Li, C. Y., Yen, C. L., Hsu, C. K., Yu, C. K., Hsieh, H. Y., Hughes, M. W., Chen, P. C. & Shieh, C. C., 2023 Dec, In: Clinical Immunology. 257, 109855.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Citations (Scopus)

Whole-Exome Sequencing Identified Rare Genetic Variants Associated with Undervirilized Genitalia in Taiwanese Pediatric Patients

Tsai, M. C., Weng, Y. H., Lin, Y. F., Wang, Y. C., Yu, H. W., Chou, Y. Y. & Chen, P. C., 2023 Feb, In: Biomedicines. 11, 2, 242.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Citations (Scopus)

2022

Mutational analysis of epidermolysis bullosa in Taiwan by whole-exome sequencing complemented by RNA sequencing: a series of 77 patients

Tu, W. T., Hou, P. C., Chen, P. C., Chen, W. R., Huang, H. Y., Wang, J. Y., Huang, Y. T., Wu, Y. H., Su, C. L., Tang, Y. A., Iwata, H., Natsuga, K., Chao, S. C., Sun, H. S., Tang, M. J., Lee, J. Y. Y., McGrath, J. A. & Hsu, C. K., 2022 Dec, In: Orphanet Journal of Rare Diseases. 17, 1, 451.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Citations (Scopus)

RNA bisulfite sequencing reveals NSUN2-mediated suppression of epithelial differentiation in pancreatic cancer

Chen, S. Y., Chen, K. L., Ding, L. Y., Yu, C. H., Wu, H. Y., Chou, Y. Y., Chang, C. J., Chang, C. H., Wu, Y. N., Wu, S. R., Hou, Y. C., Lee, C. T., Chen, P. C., Shan, Y. S. & Huang, P. H., 2022 May 27, In: Oncogene. 41, 22, p. 3162-3176 15 p.

Research output: Contribution to journal › Article › peer-review

36 Citations (Scopus)

2021

FGF primes angioblast formation by inducing ETV2 and LMO2 via FGFR1/BRAF/MEK/ERK

Chen, P. C., Hsueh, Y. W., Lee, Y. H., Tsai, H. W., Tsai, K. J. & Chiang, P. M., 2021 Mar, In: Cellular and Molecular Life Sciences. 78, 5, p. 2199-2212 14 p.

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

New Structural and Single Nucleotide Mutations in Type I and Type II Collagens in Taiwanese Children With Type I and Type II Collagenopathies

Tsai, M. C., Chou, Y. Y., Li, C. Y., Wang, Y. C., Yu, H. W., Chen, C. H. & Chen, P. C., 2021 Jul 28, In: Frontiers in Genetics. 12, 594285.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Citation (Scopus)

NOX2-Deficient Neutrophils Facilitate Joint Inflammation Through Higher Pro-Inflammatory and Weakened Immune Checkpoint Activities

Liao, Y. C., Wu, S. Y., Huang, Y. F., Lo, P. C., Chan, T. Y., Chen, C. A., Wu, C. H., Hsu, C. C., Yen, C. L., Chen, P. C. & Shieh, C. C., 2021 Sept 7, In: Frontiers in Immunology. 12, 743030.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Citations (Scopus)

2020

A novel pathogenic mutation on Interleukin-7 receptor leading to severe combined immunodeficiency identified with newborn screening and whole exome sequencing

Liao, C. Y., Yu, H. W., Cheng, C. N., Chen, J. S., Lin, C. W., Chen, P. C. & Shieh, C. C., 2020 Feb, In: Journal of Microbiology, Immunology and Infection. 53, 1, p. 99-105 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Citations (Scopus)

Plectin missense mutation p.Leu319pro in the pathogenesis of autosomal recessive epidermolysis bullosa simplex

Tu, W. T., Chen, P. C., Hou, P. C., Huang, H. Y., Wang, J. Y., Chao, S. C., Lee, Y-Y., McGrath, J. A., Natsuga, K. & Hsu, C. K., 2020 Aug, In: Acta Dermato-Venereologica. 100, 15, p. 1-2 2 p., adv00242.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Citations (Scopus)

Probiotics-containing yogurt ingestion and H. pylori eradication can restore fecal Faecalibacterium prausnitzii dysbiosis in H. pylori-infected children

Yang, Y. J., Chen, P. C., Lai, F. P., Tsai, P. J. & Sheu, B. S., 2020 Jun 1, In: Biomedicines. 8, 6, 146.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Citations (Scopus)

Two cases of interleukin-7-deficient generalized verrucosis

Kosumi, H., Natsuga, K., Takashima, S., Miyauchi, T., Huang, Y. T., Nomura, T., Yanagi, T., Huang, H. Y., Chiu, F. P. C., Chen, P. C., Hsu, C. K. & Shimizu, H., 2020 Sept 15, In: Clinical Infectious Diseases. 71, 6, p. 1561-1563 3 p.

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

2018

Rare compound heterozygous frameshift mutations in ALMS1 gene identified through exome sequencing in a Taiwanese patient with Alström syndrome

Tsai, M. C., Yu, H. W., Liu, T., Chou, Y. Y., Chiou, Y. Y. & Chen, P. C., 2018 Apr 18, In: Frontiers in Genetics. 9, APR, 110.

Research output: Contribution to journal › Article › peer-review

Open Access

10 Citations (Scopus)

2014

Comprehensive molecular profiling of lung adenocarcinoma: The cancer genome atlas research network

Collisson, E. A., Campbell, J. D., Brooks, A. N., Berger, A. H., Lee, W., Chmielecki, J., Beer, D. G., Cope, L., Creighton, C. J., Danilova, L., Ding, L., Getz, G., Hammerman, P. S., Hayes, D. N., Hernandez, B., Herman, J. G., Heymach, J. V., Jurisica, I., Kucherlapati, R., Kwiatkowski, D., & 290 othersLadanyi, M., Robertson, G., Schultz, N., Shen, R., Sinha, R., Sougnez, C., Tsao, M. S., Travis, W. D., Weinstein, J. N., Wigle, D. A., Wilkerson, M. D., Chu, A., Cherniack, A. D., Hadjipanayis, A., Rosenberg, M., Weisenberger, D. J., Laird, P. W., Radenbaugh, A., Ma, S., Stuart, J. M., Byers, L. A., Baylin, S. B., Govindan, R., Meyerson, M., Gabriel, S. B., Cibulskis, K., Kim, J., Stewart, C., Lichtenstein, L., Lander, E. S., Lawrence, M. S., Getz, E., Fulton, R., Fulton, L. L., McLellan, M. D., Wilson, R. K., Ye, K., Fronick, C. C., Maher, C. A., Miller, C. A., Wendl, M. C., Cabanski, C., Mardis, E., Wheeler, D., Balasundaram, M., Butterfield, Y. S. N., Carlsen, R., Chuah, E., Dhalla, N., Guin, R., Hirst, C., Lee, D., Li, H. I., Mayo, M., Moore, R. A., Mungall, A. J., Schein, J. E., Sipahimalani, P., Tam, A., Varhol, R., Robertson, A. G., Wye, N., Thiessen, N., Holt, R. A., Jones, S. J. M., Marra, M. A., Imielinski, M., Onofrio, R. C., Hodis, E., Zack, T., Helman, E., Pedamallu, C. S., Mesirov, J., Saksena, G., Schumacher, S. E., Carter, S. L., Garraway, L., Beroukhim, R., Lee, S., Mahadeshwar, H. S., Pantazi, A., Protopopov, A., Ren, X., Seth, S., Song, X., Tang, J., Yang, L., Zhang, J., Chen, P. C., Parfenov, M., Xu, A. W., Santoso, N., Chin, L., Park, P. J., Hoadley, K. A., Auman, J. T., Meng, S., Shi, Y., Buda, E., Waring, S., Veluvolu, U., Tan, D., Mieczkowski, P. A., Jones, C. D., Simons, J. V., Soloway, M. G., Bodenheimer, T., Jefferys, S. R., Roach, J., Hoyle, A. P., Wu, J., Balu, S., Singh, D., Prins, J. F., Marron, J. S., Parker, J. S., Perou, C. M., Liu, J., Maglinte, D. T., Lai, P. H., Bootwalla, M. S., Van Den Berg, D. J., Triche, T., Cho, J., DiCara, D., Heiman, D., Lin, P., Mallard, W., Voet, D., Zhang, H., Zou, L., Noble, M. S., Gehlenborg, N., Thorvaldsdottir, H., Nazaire, M. D., Robinson, J., Aksoy, B. A., Ciriello, G., Taylor, B. S., Dresdner, G., Gao, J., Gross, B., Seshan, V. E., Reva, B., Sumer, S. O., Weinhold, N., Sander, C., Ng, S., Zhu, J., Benz, C. C., Yau, C., Haussler, D., Spellman, P. T., Kimes, P. K., Broom, B. M., Wang, J., Lu, Y., Ng, P. K. S., Diao, L., Liu, W., Amos, C. I., Akbani, R., Mills, G. B., Curley, E., Paulauskis, J., Lau, K., Morris, S., Shelton, T., Mallery, D., Gardner, J., Penny, R., Saller, C., Tarvin, K., Richards, W. G., Cerfolio, R., Bryant, A., Raymond, D. P., Pennell, N. A., Farver, C., Czerwinski, C., Huelsenbeck-Dill, L., Iacocca, M., Petrelli, N., Rabeno, B., Brown, J., Bauer, T., Dolzhanskiy, C. O., Potapova, O., Rotin, D., Voronina, O., Nemirovich-Danchenko, E., Fedosenko, K. V., Gal, A., Behera, M., Ramalingam, S. S., Sica, G., Flieder, D., Boyd, J., Weaver, J. E., Kohl, B., Thinh, D. H. Q., Sandusky, G., Juhl, H., Duhig, E., Illei, P., Gabrielson, E., Shin, J., Lee, B., Rogers, K., Trusty, D., Brock, M. V., Williamson, C., Burks, E., Rieger-Christ, K., Holway, A., Sullivan, T., Asiedu, M. K., Kosari, F., Rekhtman, N., Zakowski, M., Rusch, V. W., Zippile, P., Suh, J., Pass, H., Goparaju, C., Owusu-Sarpong, Y., Bartlett, J. M. S., Kodeeswaran, S., Parfitt, J., Sekhon, H., Albert, M., Eckman, J., Myers, J. B., Morrison, C., Gaudioso, C., Borgia, J. A., Bonomi, P., Pool, M., Liptay, M. J., Moiseenko, F., Zaytseva, I., Dienemann, H., Meister, M., Schnabel, P. A., Muley, T. R., Peifer, M., Gomez-Fernandez, C., Herbert, L., Egea, S., Huang, M., Thorne, L. B., Boice, L., Salazar, A. H., Funkhouser, W. K., Rathmell, W. K., Dhir, R., Yousem, S. A., Dacic, S., Schneider, F., Siegfried, J. M., Hajek, R., Watson, M. A., McDonald, S., Meyers, B., Clarke, B., Yang, I. A., Fong, K. M., Hunter, L., Windsor, M., Bowman, R. V., Peters, S., Letovanec, I., Khan, K. Z., Jensen, M. A., Snyder, E. E., Srinivasan, D., Kahn, A. B., Baboud, J., Pot, D. A., Shaw, K. R. M., Sheth, M., Davidsen, T., Demchok, J. A., Yang, L., Wang, Z., Tarnuzzer, R., Zenklusen, J. C., Ozenberger, B. A., Sofia, H. J. & Cheney, R., 2014, In: Nature. 511, 7511, p. 543-550 8 p.

Research output: Contribution to journal › Article › peer-review

4393 Citations (Scopus)

Next-generation sequencing identifies rare variants associated with Noonan syndrome

Chen, P. C., Yin, J., Yu, H. W., Yuan, T., Fernandez, M., Yung, C. K., Trinh, Q. M., Peltekova, V. D., Reid, J. G., Tworog-Dube, E., Morgan, M. B., Muzny, D. M., Stein, L., McPherson, J. D., Roberts, A. E., Gibbs, R. A., Neel, B. G. & Kucherlapati, R., 2014 Aug 5, In: Proceedings of the National Academy of Sciences of the United States of America. 111, 31, p. 11473-11478 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

146 Citations (Scopus)

2013

The somatic genomic landscape of glioblastoma

TCGA Research Network, 2013 Oct 10, In: Cell. 155, 2, p. 462 1 p.

Research output: Contribution to journal › Article › peer-review

3854 Citations (Scopus)

2012

Comprehensive genomic characterization of squamous cell lung cancers

Hammerman, P. S., Voet, D., Lawrence, M. S., Voet, D., Jing, R., Cibulskis, K., Sivachenko, A., Stojanov, P., McKenna, A., Lander, E. S., Gabriel, S., Getz, G., Imielinski, M., Helman, E., Hernandez, B., Pho, N. H., Meyerson, M., Chu, A., Hye-Chun, J. E., Mungall, A. J., & 316 othersPleasance, E., Robertson, A. G., Sipahimalani, P., Stoll, D., Balasundaram, M., Birol, I., Butterfield, Y. S. N., Chuah, E., Coope, R. J. N., Corbett, R., Dhalla, N., Guin, R., He, A., Hirst, C., Hirst, M., Holt, R. A., Lee, D., Li, H. I., Mayo, M., Moore, R. A., Mungall, K., Nip, K. M., Olshen, A., Schein, J. E., Slobodan, J. R., Tam, A., Thiessen, N., Varhol, R., Zeng, T., Zhao, Y., Jones, S. J. M., Marra, M. A., Saksena, G., Cherniack, A. D., Schumacher, S. E., Tabak, B., Carter, S. L., Nguyen, H., Onofrio, R. C., Crenshaw, A., Ardlie, K., Beroukhim, R., Winckler, W., Protopopov, A., Zhang, J., Hadjipanayis, A., Lee, S., Xi, R., Yang, L., Ren, X., Zhang, H., Shukla, S., Chen, P. C., Haseley, P., Lee, E., Chin, L., Park, P. J., Kucherlapati, R., Socci, N. D., Liang, Y., Schultz, N., Borsu, L., Lash, A. E., Viale, A., Sander, C., Ladanyi, M., Auman, J. T., Hoadley, K. A., Wilkerson, M. D., Shi, Y., Liquori, C., Meng, S., Li, L., Turman, Y. J., Topal, M. D., Tan, D., Waring, S., Buda, E., Walsh, J., Jones, C. D., Mieczkowski, P. A., Singh, D., Wu, J., Gulabani, A., Dolina, P., Bodenheimer, T., Hoyle, A. P., Simons, J. V., Soloway, M. G., Stuart, J., Mose, L. E., Jefferys, S. R., Balu, S., O'Connor, B. D., Chiang, D., Liu, J., Chiang, D. Y., Hayes, D. N., Perou, C. M., Cope, L., Weisenberger, D., Danilova, L., Weisenberger, D. J., Maglinte, D. T., Pan, F., Van Den Berg, D. J., Triche, T., Herman, J. G., Baylin, S. B., Laird, P. W., Noble, M., Gehlenborg, N., DiCara, D., Zhang, J., Wu, C. J., Liu, S. Y., Zou, L., Lin, P., Cho, J., Nazaire, M. D., Robinson, J., Thorvaldsdottir, H., Mesirov, J., Sinha, R., Ciriello, G., Cerami, E., Gross, B., Jacobsen, A., Gao, J., Aksoy, B. A., Weinhold, N., Ramirez, R., Taylor, B. S., Antipin, Y., Reva, B., Mo, Q., Seshan, V., Paik, P. K., Akbani, R., Zhang, N., Broom, B. M., Casasent, T., Unruh, A., Wakefield, C., Cason, R. C., Baggerly, K. A., Weinstein, J. N., Haussler, D., Benz, C. C., Stuart, J. M., Zhu, J., Szeto, C., Scott, G. K., Yau, C., Ng, S., Goldstein, T., Waltman, P., Sokolov, A., Collisson, E., Ellrott, K., Collisson, E. A., Zerbino, D., Ma, S., Craft, B., Du, Y., Cabanski, C., Walter, V., Marron, J. S., Liu, Y., Wang, K., Prins, J. F., Creighton, C. J., Zhang, Y., Travis, W. D., Rekhtman, N., Yi, J., Aubry, M. C., Cheney, R., Dacic, S., Flieder, D., Funkhouser, W., Illei, P., Myers, J., Tsao, M. S., Penny, R., Mallery, D., Shelton, T., Hatfield, M., Morris, S., Yena, P., Shelton, C., Sherman, M., Paulauskis, J., Govindan, R., Azodo, I., Beer, D., Bose, R., Byers, L. A., Carbone, D., Chang, L. W., Chun, E., Ding, L., Heymach, J., Ida, C., Johnson, B., Jurisica, I., Kaufman, J., Kosari, F., Kwiatkowski, D., Maher, C. A., Pao, W., Peifer, M., Robertson, G., Rusch, V., Siegfried, J., Sougnez, C., Thomas, R. K., Tomaszek, S., Vaske, C., Wheeler, D., Wigle, D. A., Wilks, C., Zhang, J. J., Jensen, M. A., Sfeir, R., Kahn, A. B., Chu, A. L., Kothiyal, P., Wang, Z., Snyder, E. E., Pontius, J., Pihl, T. D., Backus, M., Walton, J., Baboud, J., Berton, D. L., Nicholls, M. C., Srinivasan, D., Raman, R., Girshik, S., Kigonya, P. A., Alonso, S., Sanbhadti, R. N., Barletta, S. P., Greene, J. M., Pot, D. A., Bandarchi-Chamkhaleh, B., Boyd, J., Weaver, J., Azodo, I. A., Tomaszek, S. C., Yang, P., Brock, M. V., Rogers, K., Rutledge, M., Brown, T., Lee, B., Shin, J., Trusty, D., Dhir, R., Siegfried, J. M., Potapova, O., Fedosenko, K. V., Zakowski, M., Nemirovich-Danchenko, E., Iacocca, M. V., Brown, J., Rabeno, B., Czerwinski, C., Petrelli, N., Fan, Z., Todaro, N., Eckman, J., Rathmell, W. K., Thorne, L. B., Huang, M., Boice, L., Hill, A., Curley, E., Morrison, C., Gaudioso, C., Bartlett, J. M. S., Kodeeswaran, S., Zanke, B., Sekhon, H., David, K., Juhl, H., Le, X. V., Kohl, B., Thorp, R., Tien, N. V., Bang, N. V., Sussman, H., Phu, B. D., Hajek, R., Hung, N. P., Khan, K. Z., Muley, T., Mills Shaw, K. R., Sheth, M., Yang, L., Demchok, J. A., Davidsen, T., Buetow, K., Eley, G., Ferguson, M., Dillon, L. A. L., Schaefer, C., Guyer, M. S., Ozenberger, B. A., Palchik, J. D., Peterson, J., Sofia, H. J., Thomson, E., Johnson, B. E. & Shen, R., 2012 Sept 27, In: Nature. 489, 7417, p. 519-525 7 p.

Research output: Contribution to journal › Article › peer-review

3316 Citations (Scopus)

Comprehensive molecular characterization of human colon and rectal cancer

Muzny, D. M., Bainbridge, M. N., Chang, K., Dinh, H. H., Drummond, J. A., Fowler, G., Kovar, C. L., Lewis, L. R., Morgan, M. B., Newsham, I. F., Reid, J. G., Santibanez, J., Shinbrot, E., Trevino, L. R., Wu, Y. Q., Wang, M., Gunaratne, P., Donehower, L. A., Creighton, C. J., Wheeler, D. A., & 293 othersGibbs, R. A., Lawrence, M. S., Voet, D., Jing, R., Cibulskis, K., Sivachenko, A., Stojanov, P., McKenna, A., Lander, E. S., Gabriel, S., Ding, L., Fulton, R. S., Koboldt, D. C., Wylie, T., Walker, J., Dooling, D. J., Fulton, L., Delehaunty, K. D., Fronick, C. C., Demeter, R., Mardis, E. R., Wilson, R. K., Chu, A., Chun, H. J. E., Mungall, A. J., Pleasance, E., Gordon Robertson, A., Stoll, D., Balasundaram, M., Birol, I., Butterfield, Y. S. N., Chuah, E., Coope, R. J. N., Dhalla, N., Guin, R., Hirst, C., Hirst, M., Holt, R. A., Lee, D., Li, H. I., Mayo, M., Moore, R. A., Schein, J. E., Slobodan, J. R., Tam, A., Thiessen, N., Varhol, R., Zeng, T., Zhao, Y., Jones, S. J. M., Marra, M. A., Bass, A. J., Ramos, A. H., Saksena, G., Cherniack, A. D., Schumacher, S. E., Tabak, B., Carter, S. L., Pho, N. H., Nguyen, H., Onofrio, R. C., Crenshaw, A., Ardlie, K., Beroukhim, R., Winckler, W., Meyerson, M., Protopopov, A., Hadjipanayis, A., Lee, E., Xi, R., Yang, L., Ren, X., Sathiamoorthy, N., Chen, P. C., Haseley, P., Xiao, Y., Lee, S., Seidman, J., Chin, L., Park, P. J., Kucherlapati, R., Todd Auman, J., Hoadley, K. A., Du, Y., Wilkerson, M. D., Shi, Y., Liquori, C., Meng, S., Li, L., Turman, Y. J., Topal, M. D., Tan, D., Waring, S., Buda, E., Walsh, J., Jones, C. D., Mieczkowski, P. A., Singh, D., Wu, J., Gulabani, A., Dolina, P., Bodenheimer, T., Hoyle, A. P., Simons, J. V., Soloway, M., Mose, L. E., Jefferys, S. R., Balu, S., O'Connor, B. D., Prins, J. F., Chiang, D. Y., Neil Hayes, D., Perou, C. M., Hinoue, T., Weisenberger, D. J., Maglinte, D. T., Pan, F., Berman, B. P., Van Den Berg, D. J., Shen, H., Triche, T., Baylin, S. B., Laird, P. W., Getz, G., Noble, M., Voat, D., Gehlenborg, N., Dicara, D., Zhang, J., Zhang, H., Wu, C. J., Liu, S. Y., Shukla, S., Zhou, L., Lin, P., Park, R. W., Nazaire, M. D., Robinson, J., Thorvaldsdottir, H., Mesirov, J., Thorsson, V., Reynolds, S. M., Bernard, B., Kreisberg, R., Lin, J., Iype, L., Bressler, R., Erkkilä, T., Gundapuneni, M., Liu, Y., Norberg, A., Robinson, T., Yang, D., Zhang, W., Shmulevich, I., De Ronde, J. J., Schultz, N., Cerami, E., Ciriello, G., Goldberg, A. P., Gross, B., Jacobsen, A., Gao, J., Kaczkowski, B., Sinha, R., Arman Aksoy, B., Antipin, Y., Reva, B., Shen, R., Taylor, B. S., Ladanyi, M., Sander, C., Akbani, R., Zhang, N., Broom, B. M., Casasent, T., Unruh, A., Wakefield, C., Hamilton, S. R., Craig Cason, R., Baggerly, K. A., Weinstein, J. N., Haussler, D., Benz, C. C., Stuart, J. M., Benz, S. C., Zachary Sanborn, J., Vaske, C. J., Zhu, J., Szeto, C., Scott, G. K., Yau, C., Ng, S., Goldstein, T., Ellrott, K., Collisson, E., Cozen, A. E., Zerbino, D., Wilks, C., Craft, B., Spellman, P., Penny, R., Shelton, T., Hatfield, M., Morris, S., Yena, P., Shelton, C., Sherman, M., Paulauskis, J., Gastier-Foster, J. M., Bowen, J., Ramirez, N. C., Black, A., Pyatt, R., Wise, L., White, P., Bertagnolli, M., Brown, J., Chan, T. A., Chu, G. C., Czerwinski, C., Denstman, F., Dhir, R., Dörner, A., Fuchs, C. S., Guillem, J. G., Iacocca, M., Juhl, H., Kaufman, A., Iii, B. K., Van Le, X., Mariano, M. C., Medina, E. N., Meyers, M., Nash, G. M., Paty, P. B., Petrelli, N., Rabeno, B., Richards, W. G., Solit, D., Swanson, P., Temple, L., Tepper, J. E., Thorp, R., Vakiani, E., Weiser, M. R., Willis, J. E., Witkin, G., Zeng, Z., Zinner, M. J., Zornig, C., Jensen, M. A., Sfeir, R., Kahn, A. B., Chu, A. L., Kothiyal, P., Wang, Z., Snyder, E. E., Pontius, J., Pihl, T. D., Ayala, B., Backus, M., Walton, J., Whitmore, J., Baboud, J., Berton, D. L., Nicholls, M. C., Srinivasan, D., Raman, R., Girshik, S., Kigonya, P. A., Alonso, S., Sanbhadti, R. N., Barletta, S. P., Greene, J. M., Pot, D. A., Shaw, K. R. M., Dillon, L. A. L., Buetow, K., Davidsen, T., Demchok, J. A., Eley, G., Ferguson, M., Fielding, P., Schaefer, C., Sheth, M., Yang, L., Guyer, M. S., Ozenberger, B. A., Palchik, J. D., Peterson, J., Sofia, H. J. & Thomson., E., 2012 Jul 19, In: Nature. 487, 7407, p. 330-337 8 p.

Research output: Contribution to journal › Article › peer-review

6868 Citations (Scopus)

2011

The dual PI3K/mTOR inhibitor NVP-bez235 induces tumor regression in a genetically engineered mouse model of PIK3CA wild-type colorectal cancer

Roper, J., Richardson, M. P., Wang, W. V., Richard, L. G., Chen, W., Coffee, E. M., Sinnamon, M. J., Lee, L., Chen, P. C., Bronson, R. T., Martin, E. S. & Hung, K. E., 2011 Sept 26, In: PloS one. 6, 9, e25132.

Research output: Contribution to journal › Article › peer-review

Open Access

126 Citations (Scopus)

2010

Activation of multiple signaling pathways causes developmental defects in mice with a Noonan syndrome-associated Sos1 mutation

Chen, P. C., Wakimoto, H., Conner, D., Araki, T., Yuan, T., Roberts, A., Seidman, C. E., Bronson, R., Neel, B. G., Seidman, J. G. & Kucherlapati, R., 2010 Dec 1, In: Journal of Clinical Investigation. 120, 12, p. 4353-4365 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

94 Citations (Scopus)

2008

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

McLendon, R., Friedman, A., Bigner, D., Van Meir, E. G., Brat, D. J., Mastrogianakis, G. M., Olson, J. J., Mikkelsen, T., Lehman, N., Aldape, K., Yung, W. K. A., Bogler, O., Weinstein, J. N., VandenBerg, S., Berger, M., Prados, M., Muzny, D., Morgan, M., Scherer, S., Sabo, A., & 211 othersNazareth, L., Lewis, L., Hall, O., Zhu, Y., Ren, Y., Alvi, O., Yao, J., Hawes, A., Jhangiani, S., Fowler, G., San Lucas, A., Kovar, C., Cree, A., Dinh, H., Santibanez, J., Joshi, V., Gonzalez-Garay, M. L., Miller, C. A., Milosavljevic, A., Donehower, L., Wheeler, D. A., Gibbs, R. A., Cibulskis, K., Sougnez, C., Fennell, T., Mahan, S., Wilkinson, J., Ziaugra, L., Onofrio, R., Bloom, T., Nicol, R., Ardlie, K., Baldwin, J., Gabriel, S., Lander, E. S., Ding, L., Fulton, R. S., McLellan, M. D., Wallis, J., Larson, D. E., Shi, X., Abbott, R., Fulton, L., Chen, K., Koboldt, D. C., Wendl, M. C., Meyer, R., Tang, Y., Lin, L., Osborne, J. R., Dunford-Shore, B. H., Miner, T. L., Delehaunty, K., Markovic, C., Swift, G., Courtney, W., Pohl, C., Abbott, S., Hawkins, A., Leong, S., Haipek, C., Schmidt, H., Wiechert, M., Vickery, T., Scott, S., Dooling, D. J., Chinwalla, A., Weinstock, G. M., Mardis, E. R., Wilson, R. K., Getz, G., Winckler, W., Verhaak, R. G. W., Lawrence, M. S., O'Kelly, M., Robinson, J., Alexe, G., Beroukhim, R., Carter, S., Chiang, D., Gould, J., Gupta, S., Korn, J., Mermel, C., Mesirov, J., Monti, S., Nguyen, H., Parkin, M., Reich, M., Stransky, N., Weir, B. A., Garraway, L., Golub, T., Meyerson, M., Chin, L., Protopopov, A., Zhang, J., Perna, I., Aronson, S., Sathiamoorthy, N., Ren, G., Yao, J., Wiedemeyer, W. R., Kim, H., Sek, W. K., Xiao, Y., Kohane, I. S., Seidman, J., Park, P. J., Kucherlapati, R., Laird, P. W., Cope, L., Herman, J. G., Weisenberger, D. J., Pan, F., Van Den Berg, D., Van Neste, L., Joo, M. Y., Schuebel, K. E., Baylin, S. B., Absher, D. M., Li, J. Z., Southwick, A., Brady, S., Aggarwal, A., Chung, T., Sherlock, G., Brooks, J. D., Myers, R. M., Spellman, P. T., Purdom, E., Jakkula, L. R., Lapuk, A. V., Marr, H., Dorton, S., Yoon, G. C., Han, J., Ray, A., Wang, V., Durinck, S., Robinson, M., Wang, N. J., Vranizan, K., Peng, V., Van Name, E., Fontenay, G. V., Ngai, J., Conboy, J. G., Parvin, B., Feiler, H. S., Speed, T. P., Gray, J. W., Brennan, C., Socci, N. D., Olshen, A., Taylor, B. S., Lash, A., Schultz, N., Reva, B., Antipin, Y., Stukalov, A., Gross, B., Cerami, E., Wei, Q. W., Qin, L. X., Seshan, V. E., Villafania, L., Cavatore, M., Borsu, L., Viale, A., Gerald, W., Sander, C., Ladanyi, M., Perou, C. M., Hayes, D. N., Topal, M. D., Hoadley, K. A., Qi, Y., Balu, S., Shi, Y., Wu, J., Penny, R., Bittner, M., Shelton, T., Lenkiewicz, E., Morris, S., Beasley, D., Sanders, S., Kahn, A., Sfeir, R., Chen, J., Nassau, D., Feng, L., Hickey, E., Barker, A., Gerhard, D. S., Vockley, J., Compton, C., Vaught, J., Fielding, P., Ferguson, M. L., Schaefer, C., Zhang, J., Madhavan, S., Buetow, K. H., Collins, F., Good, P., Guyer, M., Ozenberger, B., Peterson, J. & Thomson, E., 2008 Oct 23, In: Nature. 455, 7216, p. 1061-1068 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

6485 Citations (Scopus)

Novel roles for MLH3 deficiency and TLE6-Like amplification in DNA mismatch repair-deficient gastrointestinal tumorigenesis and progression

Chen, P. C., Kuraguchi, M., Velasquez, J., Wang, Y., Yang, K., Edwards, R., Gillen, D., Edelmann, W., Kucherlapati, R. & Lipkin, S. M., 2008 Jun, In: PLoS genetics. 4, 6, e1000092.

Research output: Contribution to journal › Article › peer-review

Open Access

30 Citations (Scopus)

2006

A role for the MutL mismatch repair Mlh3 protein in immunoglobulin class switch DNA recombination and somatic hypermutation

Wu, X., Tsai, C. Y., Patam, M. B., Zan, H., Chen, J. P., Lipkin, S. M. & Casali, P., 2006 May 1, In: Journal of Immunology. 176, 9, p. 5426-5437 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

34 Citations (Scopus)

2005

Contributions by MutL homologues Mlh3 and Pms2 to DNA mismatch repair and tumor suppression in the mouse

Chen, P. C., Dudley, S., Hagen, W., Dizon, D., Paxton, L., Reichow, D., Yoon, S. R., Yang, K., Arnheim, N., Liskay, R. M. & Lipkin, S. M., 2005 Oct 1, In: Cancer Research. 65, 19, p. 8662-8670 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

91 Citations (Scopus)

Kinetics of cancer: A method to test hypotheses of genetic causation

Frank, S. A., Chen, P. C. & Lipkin, S. M., 2005 Dec 21, In: BMC cancer. 5, 163.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Citations (Scopus)

2004

The MLH1 D132H variant is associated with susceptibility to sporadic colorectal cancer

Lipkin, S. M., Rozek, L. S., Rennert, G., Yang, W., Chen, P. C., Hacia, J., Hunt, N., Shin, B., Fodor, S., Kokoris, M., Greenson, J. K., Fearon, E., Lynch, H., Collins, F. & Gruber, S. B., 2004 Jul, In: Nature Genetics. 36, 7, p. 694-699 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

93 Citations (Scopus)

Peng-Chieh Chen

Research output

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