• 812 Citations
  • 16 h-Index
19982020
If you made any changes in Pure these will be visible here soon.

Research Output 1998 2019

  • 812 Citations
  • 16 h-Index
  • 24 Article
  • 6 Review article
  • 1 Chapter
2019
1 Citation (Scopus)

Stilbene compounds inhibit tumor growth by the induction of cellular senescence and the inhibition of telomerase activity

Lee, Y. H., Chen, Y. Y., Yeh, Y. L., Wang, Y. J. & Chen, R. J., 2019 Jun 1, In : International journal of molecular sciences. 20, 11, 2716.

Research output: Contribution to journalReview article

Open Access
Stilbenes
stilbene
Cell Aging
Telomerase
Tumors
2018
5 Citations (Scopus)

Apoptotic and nonapoptotic activities of pterostilbene against cancer

Chen, R-J., Kuo, H. C., Cheng, L. H., Lee, Y-H., Chang, W-T., Wang, B. J., Wang, Y-J. & Cheng, H-C., 2018 Jan 18, In : International journal of molecular sciences. 19, 1, 287.

Research output: Contribution to journalReview article

Medicine
cancer
Nutrition
Tumors
Neoplasms
2017
4 Citations (Scopus)

Autophagy-inducing effect of pterostilbene: A prospective therapeutic/preventive option for skin diseases

Chen, R-J., Lee, Y-H., Yeh, Y. L., Wu, W. S., Ho, C. T., Li, C. Y., Wang, B. J. & Wang, Y-J., 2017 Jan 1, In : Journal of Food and Drug Analysis. 25, 1, p. 125-133 9 p.

Research output: Contribution to journalArticle

autophagy
Autophagy
skin diseases
Skin Diseases
therapeutics
4 Citations (Scopus)

Evaluating the urate-lowering effects of different microbial fermented extracts in hyperuricemic models accompanied with a safety study

Chen, R-J., Chen, M. H., Chen, Y. L., Hsiao, C. M., Chen, H. M., Chen, S. J., Wu, M. D., Yech, Y. J., Yuan, G. F. & Wang, Y-J., 2017 Jul 1, In : Journal of Food and Drug Analysis. 25, 3, p. 597-606 10 p.

Research output: Contribution to journalArticle

Uric Acid
Hyperuricemia
Xanthine Oxidase
extracts
Urate Oxidase
11 Citations (Scopus)

P53-dependent downregulation of hTERT protein expression and telomerase activity induces senescence in lung cancer cells as a result of pterostilbene treatment

Chen, R. J., Wu, P. H., Ho, C. T., Way, T. D., Pan, M. H., Chen, H. M., Ho, Y. S. & Wang, Y. J., 2017 Aug 10, In : Cell death & disease. 8, 8, p. e2985

Research output: Contribution to journalArticle

Telomerase
Lung Neoplasms
Down-Regulation
Proteins
Cell Aging
2016
10 Citations (Scopus)

The roles of autophagy and the inflammasome during environmental stress-triggered skin inflammation

Chen, R-J., Lee, Y-H., Yeh, Y. L., Wang, Y-J. & Wang, B. J., 2016 Dec 9, In : International journal of molecular sciences. 17, 12, 2063.

Research output: Contribution to journalReview article

Inflammasomes
Autophagy
homeostasis
pathogenesis
Skin
2015
24 Citations (Scopus)

Strategies to prevent and reverse liver fibrosis in humans and laboratory animals

Chen, R. J., Wu, H. H. & Wang, Y. J., 2015 Oct 24, In : Archives of Toxicology. 89, 10, p. 1727-1750 24 p.

Research output: Contribution to journalReview article

Laboratory Animals
Liver Cirrhosis
Liver
Animals
Hepatic Stellate Cells
2014

Pterostilbene Protection and Bladder Cancer Cells

Wang, Y-J. & Chen, R-J., 2014 Jan 1, Cancer: Oxidative Stress and Dietary Antioxidants. Elsevier Inc., p. 271-281 11 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Urinary Bladder Neoplasms
Insurance Benefits
Antioxidants
Poisons
Autophagy
10 Citations (Scopus)

TCDD promotes lung tumors via attenuation of apoptosis through activation of the Akt and ERK1/2 signaling pathways

Chen, R-J., Siao, S. H., Hsu, C. H., Chang, C. Y., Chang, L. W., Wu, C. H., Lin, P. & Wang, Y-J., 2014 Jun 13, In : PloS one. 9, 6, e99586.

Research output: Contribution to journalArticle

tetrachlorodibenzo-p-dioxin
MAP Kinase Signaling System
lung neoplasms
Tumors
apoptosis
9 Citations (Scopus)
Pentachlorophenol
pentachlorophenol
Cell death
Metabolites
splenocytes
3 Citations (Scopus)

The regulation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumor promotion by estradiol in female A/J mice

Chen, R-J., Chang, C. Y., Chang, L. W., Siao, S. H., Ho, Y. S., Wu, C. H., Foo, N. P., Lin, P. & Wang, Y-J., 2014 Mar 28, In : PLoS ONE. 9, 3, e93152.

Research output: Contribution to journalArticle

tetrachlorodibenzo-p-dioxin
lung neoplasms
estradiol
Tumors
Estradiol
2013
8 Citations (Scopus)

The immunotoxic effects of dual exposure to PCP and TCDD

Chen, H. M., Lee, Y-H., Chen, R-J., Chiu, H. W., Wang, B. J. & Wang, Y-J., 2013 Oct 16, In : Chemico-Biological Interactions. 206, 2, p. 166-174 9 p.

Research output: Contribution to journalArticle

Pentachlorophenol
Ovalbumin
Cytotoxicity
Cytokines
1,4-dioxin
2012
36 Citations (Scopus)

Chemopreventive effects of pterostilbene on urethane-induced lung carcinogenesis in mice via the inhibition of EGFR-mediated pathways and the induction of apoptosis and autophagy

Chen, R-J., Tsai, S. J., Ho, C. T., Pan, M. H., Ho, Y. S., Wu, C. H. & Wang, Y-J., 2012 Nov 21, In : Journal of Agricultural and Food Chemistry. 60, 46, p. 11533-11541 9 p.

Research output: Contribution to journalArticle

urethane
autophagy
Urethane
Autophagy
Epidermal Growth Factor Receptor
21 Citations (Scopus)

Monascuspiloin induces apoptosis and autophagic cell death in human prostate cancer cells via the akt and AMPK signaling pathways

Chen, R-J., Hung, C. M., Chen, Y. L., Wu, M. D., Yuan, G. F. & Wang, Y-J., 2012 Jul 25, In : Journal of Agricultural and Food Chemistry. 60, 29, p. 7185-7193 9 p.

Research output: Contribution to journalArticle

AMP-Activated Protein Kinases
autophagy
Autophagy
prostatic neoplasms
Cell death
2011
39 Citations (Scopus)

Epigenetic effects and molecular mechanisms of tumorigenesis induced by cigarette smoke: An overview

Lin, P., Chen, R. J., Chang, L. W. & Wang, Y. J., 2011 Jun 22, In : Journal of Oncology. 654931.

Research output: Contribution to journalReview article

Epigenomics
Smoke
Tobacco Products
Carcinogenesis
Lung
7 Citations (Scopus)

Molecular mechanisms of nicotine-induced bladder cancer

Chen, R. J., Ho, Y. S., Wu, C. H. & Wang, Y. J., 2011 Dec 1, In : Journal of Experimental and Clinical Medicine. 3, 6, p. 252-256 5 p.

Research output: Contribution to journalReview article

Nicotine
Urinary Bladder Neoplasms
Smoke
Cyclin D1
Cell Proliferation
2010
51 Citations (Scopus)
Nicotine
Urinary Bladder Neoplasms
Adrenergic Receptors
Down-Regulation
Chemical activation
60 Citations (Scopus)

Pterostilbene induces autophagy and apoptosis in sensitive and chemoresistant human bladder cancer cells

Chen, R-J., Ho, C. T. & Wang, Y-J., 2010 Dec 1, In : Molecular Nutrition and Food Research. 54, 12, p. 1819-1832 14 p.

Research output: Contribution to journalArticle

autophagy
Autophagy
Urinary Bladder Neoplasms
apoptosis
Apoptosis
2008
27 Citations (Scopus)

NF-κB-activated tissue transglutaminase is involved in ethanol-induced hepatic injury and the possible role of propolis in preventing fibrogenesis

Chen, C. S., Wu, C. H., Lai, Y. C., Lee, W. S., Chen, H. M., Chen, R-J., Chen, L. C., Ho, Y. S. & Wang, Y-J., 2008 Apr 18, In : Toxicology. 246, 2-3, p. 148-157 10 p.

Research output: Contribution to journalArticle

Propolis
Ethanol
Liver
Wounds and Injuries
Liver Cirrhosis
88 Citations (Scopus)

Rapid activation of Stat3 and ERK1/2 by nicotine modulates cell proliferation in human bladder cancer cells

Chen, R. J., Ho, Y. S., Guo, H. R. & Wang, Y. J., 2008 Aug 1, In : Toxicological Sciences. 104, 2, p. 283-293 11 p.

Research output: Contribution to journalArticle

Mitogen-Activated Protein Kinase 3
Mitogen-Activated Protein Kinase 1
Cell proliferation
Nicotine
Urinary Bladder Neoplasms
12 Citations (Scopus)

SP1-regulated p27/Kip1 gene expression is involved in terbinafine-induced human A431 cancer cell differentiation: An in vitro and in vivo study

Huang, C. S., Ho, W. L., Lee, W. S., Sheu, M. T., Wang, Y. J., Tu, S. H., Chen, R. J., Chu, J. S., Chen, L. C., Lee, C. H., Tseng, H., Ho, Y. S. & Wu, C. H., 2008 May 1, In : Biochemical Pharmacology. 75, 9, p. 1783-1796 14 p.

Research output: Contribution to journalArticle

terbinafine
Gene expression
Tumors
Cell Differentiation
Cells
2007
25 Citations (Scopus)

Protection against arsenic trioxide-induced autophagic cell death in U118 human glioma cells by use of lipoic acid

Cheng, T. J., Wang, Y-J., Kao, W. W., Chen, R-J. & Ho, Y. S., 2007 Jun 1, In : Food and Chemical Toxicology. 45, 6, p. 1027-1038 12 p.

Research output: Contribution to journalArticle

lipoic acid
Thioctic Acid
autophagy
Autophagy
Cell death
2006
7 Citations (Scopus)

Mechanisms of apoptosis induction and cell cycle regulation in irradiated leukemia U937 cells and enhancement by arsenic trioxide

Ho, S. Y., Huang, P. C., Guo, H-R., Chang, W. H., Chen, R-J., Wei, B. L., Wu, W. J., Tai, C. & Wang, Y-J., 2006 Apr 1, In : Radiation Research. 165, 4, p. 390-399 10 p.

Research output: Contribution to journalArticle

U937 Cells
leukemias
apoptosis
arsenic
induction
3 Citations (Scopus)

Staurosporine modulates radiosensitivity and radiation-induced apoptosis in U937 cells

Guo, H-R., Chen, C-H., Ho, S. Y., Ho, Y. S., Chen, R-J. & Wang, Y-J., 2006 Feb 1, In : International Journal of Radiation Biology. 82, 2, p. 97-109 13 p.

Research output: Contribution to journalArticle

U937 Cells
Staurosporine
Radiation Tolerance
Radiation
Apoptosis
2005
88 Citations (Scopus)

Tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) induces cell proliferation in normal human bronchial epithelial cells through NFκB activation and cyclin D1 up-regulation

Ho, Y. S., Chen, C. H., Wang, Y. J., Pestell, R. G., Albanese, C., Chen, R. J., Chang, M. C., Jeng, J. H., Lin, S. Y., Liang, Y. C., Tseng, H., Lee, W. S., Lin, J. K., Chu, J. S., Chen, L. C., Lee, C. H., Tso, W. L., Lai, Y. C. & Wu, C. H., 2005 Jun 1, In : Toxicology and Applied Pharmacology. 205, 2, p. 133-148 16 p.

Research output: Contribution to journalArticle

Tobacco
Cyclin D1
Cell proliferation
Carcinogens
Up-Regulation
2003
53 Citations (Scopus)

In vitro and in vivo studies of the anticancer action of terbinafine in human cancer cell lines: G0/G1 p53-associated cell cycle arrest

Lee, W. S., Chen, R-J., Wang, Y-J., Tseng, H., Jeng, J. H., Lin, S. Y., Liang, Y. C., Chen, C. H., Lin, C. H., Lin, J. K., Ho, P. Y., Chu, J. S., Ho, W. L., Chen, L. C. & Ho, Y. S., 2003 Aug 10, In : International Journal of Cancer. 106, 1, p. 125-137 13 p.

Research output: Contribution to journalArticle

terbinafine
Cell Cycle Checkpoints
Cell Line
Neoplasms
In Vitro Techniques
2002
18 Citations (Scopus)

Ketoconazole potentiates the antitumor effects of nocodazole: In vivo therapy for human tumor xenografts in nude mice

Wang, Y-J., Jeng, J. H., Chen, R-J., Tseng, H., Chen, L. C., Liang, Y. C., Lin, C. H., Chen, C. H., Chu, J. S., Ho, W. L. & Ho, Y. S., 2002 Aug 14, In : Molecular Carcinogenesis. 34, 4, p. 199-210 12 p.

Research output: Contribution to journalArticle

Nocodazole
Ketoconazole
Heterografts
Nude Mice
Neoplasms
2001
101 Citations (Scopus)

Griseofulvin potentiates antitumorigenesis effects of nocodazole through induction of apoptosis and G2/M cell cycle arrest in human colorectal cancer cells

Ho, Y. S., Duh, J. S., Jeng, J. H., Wang, Y-J., Liang, Y. C., Lin, C. H., Tseng, C. J., Yu, C. F., Chen, R-J. & Lin, J. K., 2001 Feb 1, In : International Journal of Cancer. 91, 3, p. 393-401 9 p.

Research output: Contribution to journalArticle

G2 Phase Cell Cycle Checkpoints
Nocodazole
Griseofulvin
Colorectal Neoplasms
Apoptosis
2000
27 Citations (Scopus)

Ketoconazole induces G0/G1 arrest in human colorectal and hepatocellular carcinoma cell lines

Chen, R-J., Lee, W. S., Liang, Y. C., Lin, J. K., Wang, Y-J., Lin, C. H., Hsieh, J. Y., Chaing, C. C. & Ho, Y. S., 2000 Dec 1, In : Toxicology and Applied Pharmacology. 169, 2, p. 132-141 10 p.

Research output: Contribution to journalArticle

Ketoconazole
Hepatocellular Carcinoma
Colorectal Neoplasms
Cells
Cell Line
1999
26 Citations (Scopus)

Induction of apoptosis by S-nitrosoglutathione and Cu2+ or Ni2+ ion through modulation of bax, bad, and bcl-2 proteins in human colon adenocarcinoma cells

Ho, Y. S., Liu, H. L., Duh, J. S., Chen, R-J., Ho, W. L., Jeng, J. H., Wang, Y-J. & Lin, J. K., 1999 Nov 22, In : Molecular Carcinogenesis. 26, 3, p. 201-211 11 p.

Research output: Contribution to journalArticle

S-Nitrosoglutathione
HT29 Cells
Nitric Oxide
Colon
Adenocarcinoma
1998
34 Citations (Scopus)

Ketoconazole-induced apoptosis through P53-dependent pathway in human colorectal and hepatocellular carcinoma cell lines

Ho, Y. S., Tsai, P. W., Yu, C. F., Liu, H. L., Chen, R-J. & Lin, J. K., 1998 Jan 1, In : Toxicology and Applied Pharmacology. 153, 1, p. 39-47 9 p.

Research output: Contribution to journalArticle

Ketoconazole
Hepatocellular Carcinoma
Colorectal Neoplasms
Cells
Apoptosis