• 1252 Citations
  • 18 h-Index
20052019
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Research Output 2005 2019

2019
5 Citations (Scopus)
Fibroblast Growth Factor 9
Corpus Striatum
Huntington Disease
Oxidative stress
Oxidative Stress

Lactoferrin Protects Hyperoxia-Induced Lung and Kidney Systemic Inflammation in an In Vivo Imaging Model of NF-κB/Luciferase Transgenic Mice

Yen, C. C., Chang, W. H., Tung, M. C., Chen, H. L., Liu, H. C., Liao, C. H., Lan, Y. W., Chong, K. Y., Yang, S-H. & Chen, C. M., 2019 Jan 1, In : Molecular Imaging and Biology.

Research output: Contribution to journalArticle

Hyperoxia
Lactoferrin
Luciferases
Transgenic Mice
Inflammation
2018
8 Citations (Scopus)

FGF9/FGFR2 increase cell proliferation by activating ERK1/2, Rb/E2F1, and cell cycle pathways in mouse Leydig tumor cells

Chang, M. M., Lai, M. S., Hong, S. Y., Pan, B. S., Huang, H., Yang, S. H., Wu, C. C., Sun, H. S., Chuang, J. I., Wang, C. Y. & Huang, B. M., 2018 Nov 1, In : Cancer Science. 109, 11, p. 3503-3518 16 p.

Research output: Contribution to journalArticle

Fibroblast Growth Factor 9
Leydig Cell Tumor
Fibroblast Growth Factor Receptors
Retinoblastoma
Fibroblast Growth Factor 2
3 Citations (Scopus)

Fibroblast Growth Factor 9 Suppresses Striatal Cell Death Dominantly Through ERK Signaling in Huntington's Disease

Yusuf, I. O., Cheng, P. H., Chen, H. M., Chang, Y. F., Chang, C. Y., Yang, H. I., Lin, C. W., Tsai, S. J., Chuang, J. I., Wu, C. C., Huang, B. M., Sun, H. S. & Yang, S. H., 2018 Aug 1, In : Cellular Physiology and Biochemistry. 48, 2, p. 605-617 13 p.

Research output: Contribution to journalArticle

Fibroblast Growth Factor 9
Corpus Striatum
Huntington Disease
Cell Death
MAP Kinase Signaling System
2017
3 Citations (Scopus)

A novel osteoporosis model with ascorbic acid deficiency in Akr1A1 gene knockout mice

Lai, C. W., Chen, H. L., Tu, M. Y., Lin, W. Y., Röhrig, T., Yang, S-H., Lan, Y. W., Chong, K. Y. & Chen, C. M., 2017 Jan 1, In : Oncotarget. 8, 5, p. 7357-7369 13 p.

Research output: Contribution to journalArticle

Ascorbic Acid Deficiency
Gene Knockout Techniques
Knockout Mice
Ascorbic Acid
Osteoporosis

CCAAT/enhancer-binding protein delta promotes intracellular lipid accumulation in M1 macrophages of vascular lesions

Lai, H., Hsu, L., Tsai, H., Lo, Y., Yang, S., Liu, P. & Wang, Y-M., 2017 Sep 1, In : Cardiovascular Research. 113, 11, p. 1376-1388

Research output: Contribution to journalArticle

4 Citations (Scopus)

CCAAT/enhancer-binding protein delta promotes intracellular lipid accumulation in M1 macrophages of vascular lesions

Lai, H. Y., Hsu, L. W., Tsai, H. H., Lo, Y-C., Yang, S-H., Liu, P-Y. & Wang, J-M., 2017 Jan 1, In : Cardiovascular Research. 113, 11, p. 1376-1388 13 p.

Research output: Contribution to journalArticle

CCAAT-Enhancer-Binding Protein-delta
Blood Vessels
Macrophages
Lipids
Apolipoproteins E
3 Citations (Scopus)

miR-196a enhances neuronal morphology through suppressing RANBP10 to provide neuroprotection in Huntington's disease

Her, L-S., Mao, S. H., Chang, C. Y., Cheng, P. H., Chang, Y. F., Yang, H. I., Chen, C. M. & Yang, S-H., 2017 Jan 1, In : Theranostics. 7, 9, p. 2452-2462 11 p.

Research output: Contribution to journalArticle

Huntington Disease
Carrier Proteins
Aptitude
MicroRNAs
Neuronal Plasticity
10 Citations (Scopus)

The truncated C-terminal fragment of mutant ATXN3 disrupts mitochondria dynamics in spinocerebellar ataxia type 3 models

Hsu, J. Y., Jhang, Y. L., Cheng, P. H., Chang, Y. F., Mao, S. H., Yang, H. I., Lin, C. W., Chen, C. M. & Yang, S. H., 2017 Jun 20, In : Frontiers in Molecular Neuroscience. 10, 196.

Research output: Contribution to journalArticle

Machado-Joseph Disease
Mitochondria
Mitochondrial Dynamics
Transgenic Mice
Cell Death
2016
3 Citations (Scopus)

Lentiviral transgenesis in mice via a simple method of viral concentration

Cheng, P. H., Chang, Y. F., Mao, S. H., Lin, H. L., Chen, C. M. & Yang, S-H., 2016 Mar 31, In : Theriogenology. 86, 6, p. 1427-1435 9 p.

Research output: Contribution to journalArticle

Gene Transfer Techniques
Lentivirus
Genetically Modified Animals
genetically modified organisms
mice
5 Citations (Scopus)

Myostatin propeptide gene delivery by gene gun ameliorates muscle atrophy in a rat model of botulinum toxin-induced nerve denervation

Tsai, S. W., Tung, Y. T., Chen, H. L., Yang, S-H., Liu, C. Y., Lu, M., Pai, H. J., Lin, C. C. & Chen, C. M., 2016 Feb 1, In : Life Sciences. 146, p. 15-23 9 p.

Research output: Contribution to journalArticle

Myostatin
Muscular Atrophy
Botulinum Toxins
Firearms
Denervation
4 Citations (Scopus)

Sexually Dimorphic Expression of eGFP Transgene in the Akr1A1 Locus of Mouse Liver Regulated by Sex Hormone-Related Epigenetic Remodeling

Lai, C. W., Chen, H. L., Tsai, T. C., Chu, T. W., Yang, S-H., Chong, K. Y. & Chen, C. M., 2016 Apr 18, In : Scientific reports. 6, 24023.

Research output: Contribution to journalArticle

Gonadal Steroid Hormones
Transgenes
Epigenomics
Liver
Gene Expression
3 Citations (Scopus)

The expression profiles of fibroblast growth factor 9 and its receptors in developing mice testes

Lai, M. S., Wang, C-Y., Yang, S-H., Wu, C-C., Sun, H-F., Tsai, S-J., Chuang, J-I., Chen, Y. C. & Huang, B-M., 2016 Apr 2, In : Organogenesis. 12, 2, p. 61-77 17 p.

Research output: Contribution to journalArticle

Fibroblast Growth Factor 9
Fibroblasts
Testis
Spermatids
Leydig Cells
8 Citations (Scopus)

Using Dual Fluorescence Reporting Genes to Establish an In Vivo Imaging Model of Orthotopic Lung Adenocarcinoma in Mice

Lai, C. W., Chen, H. L., Yen, C. C., Wang, J. L., Yang, S-H. & Chen, C. M., 2016 Dec 1, In : Molecular Imaging and Biology. 18, 6, p. 849-859 11 p.

Research output: Contribution to journalArticle

Fluorescence
Lung
Genes
Lung Neoplasms
Neoplasms
2015
22 Citations (Scopus)

Coordination of AUF1 and miR-148a destabilizes DNA methyltransferase 1 mRNA under hypoxia in endometriosis

Hsiao, K. Y., Wu, M-H., Chang, N., Yang, S-H., Wu, C. W., Sun, H-F. & Tsai, S-J., 2015 May 28, In : Molecular Human Reproduction. 21, 12, p. 894-904 11 p.

Research output: Contribution to journalArticle

Methyltransferases
Endometriosis
MicroRNAs
Messenger RNA
DNA
35 Citations (Scopus)

Early Parkinson's disease symptoms in α-synuclein transgenic monkeys

Niu, Y., Guo, X., Chen, Y., Wang, C. E., Gao, J., Yang, W., Kang, Y., Si, W., Wang, H., Yang, S-H., Li, S., Ji, W. & Li, X. J., 2015 Apr 15, In : Human Molecular Genetics. 24, 8, p. 2308-2317 10 p., ddu748.

Research output: Contribution to journalArticle

Synucleins
Haplorhini
Parkinson Disease
Dopaminergic Neurons
Anxiety
22 Citations (Scopus)

Extracellular superoxide dismutase ameliorates streptozotocin-induced rat diabetic nephropathy via inhibiting the ROS/ERK1/2 signaling

Kuo, C. W., Shen, C. J., Tung, Y. T., Chen, H. L., Chen, Y. H., Chang, W. H., Cheng, K. C., Yang, S-H. & Chen, C. M., 2015 Jun 22, In : Life Sciences. 135, p. 77-86 10 p.

Research output: Contribution to journalArticle

Diabetic Nephropathies
Streptozocin
Mitogen-Activated Protein Kinases
Transforming Growth Factor beta
Superoxide Dismutase
16 Citations (Scopus)
Fibroblast Growth Factor 9
Fibroblast Growth Factor Receptors
Cyclic AMP Response Element-Binding Protein
Heme Oxygenase-1
Oxidation-Reduction
97 Citations (Scopus)

Functional disruption of the dystrophin gene in rhesus monkey using CRISPR/Cas9

Chen, Y., Zheng, Y., Kang, Y., Yang, W., Niu, Y., Guo, X., Tu, Z., Si, C., Wang, H., Xing, R., Pu, X., Yang, S-H., Li, S., Ji, W. & Li, X. J., 2015 Jul 1, In : Human Molecular Genetics. 24, 13, p. 3764-3774 11 p., ddv120.

Research output: Contribution to journalArticle

Clustered Regularly Interspaced Short Palindromic Repeats
Dystrophin
Macaca mulatta
Haplorhini
Mutation
48 Citations (Scopus)

MicroRNA-145 as one negative regulator of astrogliosis

Wang, C. Y., Yang, S. H. & Tzeng, S. F., 2015 Feb 1, In : GLIA. 63, 2, p. 194-205 12 p.

Research output: Contribution to journalArticle

MicroRNAs
Astrocytes
Spinal Cord Injuries
Spinal Cord
Down-Regulation
6 Citations (Scopus)

SMN is required for the maintenance of embryonic stem cells and neuronal differentiation in mice

Chang, W. F., Xu, J., Chang, C. C., Yang, S-H., Li, H. Y., Hsieh-Li, H. M., Tsai, M. H., Wu, S. C., Cheng, W. T. K., Liu, J. L. & Sung, L. Y., 2015 May 1, In : Brain Structure and Function. 220, 3, p. 1539-1553 15 p.

Research output: Contribution to journalArticle

Motor Neurons
Embryonic Stem Cells
Cell Differentiation
Maintenance
Spinal Muscular Atrophy
18 Citations (Scopus)

Stem cell transplantation therapy in Parkinson’s disease

Fu, M. H., Li, C. L., Lin, H. L., Chen, P., Calkins, M. J., Chang, Y. F., Cheng, P. H. & Yang, S-H., 2015 Dec 1, In : SpringerPlus. 4, 1, 597.

Research output: Contribution to journalReview article

Stem Cell Transplantation
Cell- and Tissue-Based Therapy
Parkinson Disease
Stem Cells
Central Nervous System
13 Citations (Scopus)

Synergy of endothelial and neural progenitor cells from adipose-derived stem cells to preserve neurovascular structures in rat hypoxic-ischemic brain injury

Hsueh, Y-Y., Chang, Y. J., Huang, C. W., Handayani, F., Chiang, Y. L., Fan, S. C., Ho, C. J., Kuo, Y-M., Yang, S-H., Chen, Y-L., Lin, S. C., Huang, C-C. & Wu, C-C., 2015 Oct 8, In : Scientific reports. 5, 14985.

Research output: Contribution to journalArticle

Brain Injuries
Stem Cells
Neuropilin-1
Receptor, Fibroblast Growth Factor, Type 1
CXC Chemokines
2 Citations (Scopus)

The Differential Profiling of Ubiquitin-Proteasome and Autophagy Systems in Different Tissues before the Onset of Huntington's Disease Models

Her, L. S., Lin, J. Y., Fu, M. H., Chang, Y. F., Li, C. L., Tang, T. Y., Jhang, Y. L., Chang, C. Y., Shih, M. C., Cheng, P. H. & Yang, S. H., 2015 Jul 1, In : Brain Pathology. 25, 4, p. 481-490 10 p.

Research output: Contribution to journalArticle

Huntington Disease
Autophagy
Proteasome Endopeptidase Complex
Ubiquitin
Inborn Genetic Diseases
12 Citations (Scopus)

The potential regulatory mechanisms of MIR-196a in huntington's disease through bioinformatic analyses

Fu, M. H., Li, C. L., Lin, H. L., Tsai, S. J., Lai, Y. Y., Chang, Y. F., Cheng, P. H., Chen, C. M. & Yang, S. H., 2015 Sep 16, In : PloS one. 10, 9, A1247.

Research output: Contribution to journalArticle

Huntington Disease
Bioinformatics
cytoskeleton
Computational Biology
Cytoskeleton
2014
10 Citations (Scopus)

Lactoferrin protects against chemical-induced rat liver fibrosis by inhibiting stellate cell activation

Tung, Y. T., Tang, T. Y., Chen, H. L., Yang, S-H., Chong, K. Y., Cheng, W. T. K. & Chen, C. M., 2014 Jan 1, In : Journal of Dairy Science. 97, 6, p. 3281-3291 11 p.

Research output: Contribution to journalArticle

liver cirrhosis
Lactoferrin
lactoferrin
Liver Cirrhosis
Dimethylnitrosamine
2 Citations (Scopus)

Recombinant derp5 allergen with αS1-casein signal peptide secreted in murine milk protects against dust mite allergen-induced airway inflammation

Liu, H. C., Pai, S. Y., Chen, H. L., Lai, C. W., Tsai, T. C., Cheng, W. T. K., Yang, S-H. & Chen, C. M., 2014 Nov 1, In : Journal of Dairy Science. 97, 11, p. 6792-6803 12 p.

Research output: Contribution to journalArticle

dust mites
Mites
Protein Sorting Signals
Caseins
allergens
2013
8 Citations (Scopus)

Ingestion of milk containing the Dp2 peptide, a dust mite allergen, protects mice from allergic airway inflammation and hyper-responsiveness

Liu, H. C., Pai, S. Y., Cheng, W. T. K., Chen, H. L., Tsai, T. C., Yang, S. H. & Chen, C. M., 2013 Jun 13, In : Allergy, Asthma and Clinical Immunology. 9, 1, 21.

Research output: Contribution to journalArticle

Respiratory Hypersensitivity
Mites
Dust
Allergens
Milk
11 Citations (Scopus)

Longitudinal transcriptomic dysregulation in the peripheral blood of transgenic Huntington's disease monkeys

Kocerha, J., Liu, Y., Willoughby, D., Chidamparam, K., Benito, J., Nelson, K., Xu, Y., Chi, T., Engelhardt, H., Moran, S., Yang, S-H., Li, S. H., Li, X. J., Larkin, K., Neumann, A., Banta, H., Yang, J. J. & Chan, A. W. S., 2013 Aug 17, In : BMC Neuroscience. 14, 88.

Research output: Contribution to journalArticle

Huntington Disease
Haplorhini
Primate Diseases
Disease Progression
Neurodegenerative Diseases
49 Citations (Scopus)

MiR-196a ameliorates phenotypes of huntington disease in cell, transgenic mouse, and induced pluripotent stem cell models

Cheng, P. H., Li, C. L., Chang, Y. F., Tsai, S-J., Lai, Y. Y., Chan, A. W. S., Chen, C. M. & Yang, S-H., 2013 Aug 8, In : American Journal of Human Genetics. 93, 2, p. 306-312 7 p.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Huntington Disease
Transgenic Mice
Phenotype
MicroRNAs
14 Citations (Scopus)

Overexpression of Smad proteins, especially Smad7, in oral epithelial dysplasias

Chen, Y. K., Huang, A. H. C., Cheng, P. H., Yang, S-H. & Lin, L. M., 2013 Jan 1, In : Clinical Oral Investigations. 17, 3, p. 921-932 12 p.

Research output: Contribution to journalArticle

Smad Proteins
Squamous Cell Carcinoma
Mouth Mucosa
Hyperplasia
Transforming Growth Factors
13 Citations (Scopus)

Significantly differential diffusion of neuropathological aggregates in the brain of transgenic mice carrying N-terminal mutant huntingtin fused with green fluorescent protein

Cheng, P. H., Li, C. L., Her, L. S., Chang, Y. F., Chan, A. W. S., Chen, C. M. & Yang, S. H., 2013 Jan 1, In : Brain Structure and Function. 218, 1, p. 283-294 12 p.

Research output: Contribution to journalArticle

Huntington Disease
Green Fluorescent Proteins
Transgenic Mice
Brain
Exons
13 Citations (Scopus)

Therapeutic potential of andrographolide isolated from the leaves of andrographis paniculata nees for treating lung adenocarcinomas

Tung, Y. T., Chen, H. L., Tsai, H. C., Yang, S. H., Chang, Y. C. & Chen, C. M., 2013 Sep 3, In : Evidence-based Complementary and Alternative Medicine. 2013, 305898.

Research output: Contribution to journalArticle

Andrographis
Neoplasms
Lung
Vascular Endothelial Growth Factor A
Therapeutics
2012
19 Citations (Scopus)

Differential differences in methylation status of putative imprinted genes among cloned swine genomes

Shen, C. J., Cheng, W. T. K., Wu, S. C., Chen, H. L., Tsai, T. C., Yang, S-H. & Chen, C. M., 2012 Feb 29, In : PloS one. 7, 2, e32812.

Research output: Contribution to journalArticle

Methylation
methylation
Swine
Epigenomics
epigenetics
73 Citations (Scopus)
Phosphorylation
Stromal Cells
MicroRNAs
Gene expression
Gene Expression
2011
8 Citations (Scopus)
Cheek
Transforming Growth Factors
Cricetinae
Carcinogenesis
Epithelial Cells
7 Citations (Scopus)

Characterization of dental pulp stem/stromal cells of Huntington monkey tooth germs

Snyder, B. R., Cheng, P. H., Yang, J., Yang, S-H., Huang, A. H. C. & Chan, A. W. S., 2011 Sep 12, In : BMC Cell Biology. 12, 39.

Research output: Contribution to journalArticle

Tooth Germ
Dental Pulp
Stromal Cells
Haplorhini
Stem Cells
20 Citations (Scopus)

Transgenic animal models of huntington's disease

Yang, S-H. & Chan, A. W. S., 2011 Dec 1, Molecular and Functional Models in NeuropsychiatrY. Hagan, J. J. (ed.). 1 ed. p. 61-85 25 p. (Current Topics in Behavioral Neurosciences; vol. 7, no. 1).

Research output: Chapter in Book/Report/Conference proceedingChapter

Genetically Modified Animals
Huntington Disease
Animal Models
Haplorhini
Primates
2010
23 Citations (Scopus)

Granzyme G is expressed in the two-cell stage mouse embryo and is required for the maternal-zygotic transition

Tsai, T. C., Lin, W., Yang, S-H., Cheng, W. T. K., Cheng, E. H., Lee, M. S., Chong, K. Y. & Chen, C. M., 2010 Aug 16, In : BMC Developmental Biology. 10, 88.

Research output: Contribution to journalArticle

Granzymes
Embryonic Structures
Mothers
Embryonic Development
Clone Cells
15 Citations (Scopus)

Monkey hybrid stem cells develop cellular features of Huntington's disease

Laowtammathron, C., Cheng, E. C. H., Cheng, P. H., Snyder, B. R., Yang, S-H., Johnson, Z., Lorthongpanich, C., Kuo, H. C., Parnpai, R. & Chan, A. W. S., 2010 Feb 5, In : BMC Cell Biology. 11, 12.

Research output: Contribution to journalArticle

Hybrid Cells
Huntington Disease
Haplorhini
Stem Cells
Pluripotent Stem Cells
2009
5 Citations (Scopus)

Assisted fertilization and embryonic axis formation in higher primates

Piotrowska-Nitsche, K., Yang, S-H., Banta, H. & Chan, A. W. S., 2009 Jan 1, In : Reproductive BioMedicine Online. 18, 3, p. 382-390 9 p.

Research output: Contribution to journalArticle

Fertilization
Primates
Spermatozoa
Intracytoplasmic Sperm Injections
Embryonic Structures
31 Citations (Scopus)

Generation of transgenic monkeys with human inherited genetic disease

Chan, A. W. S. & Yang, S-H., 2009 Sep 1, In : Methods. 49, 1, p. 78-84 7 p.

Research output: Contribution to journalReview article

Inborn Genetic Diseases
Medical Genetics
Primates
Haplorhini
Huntington Disease
58 Citations (Scopus)

Noninvasive monitoring of embryonic stem cells in vivo with MRI transgene reporter

Liu, J., Cheng, E. C. H., Long, R. C., Yang, S-H., Wang, L., Cheng, P. H., Yang, J., Wu, D., Mao, H. & Chan, A. W. S., 2009 Dec 1, In : Tissue Engineering - Part C: Methods. 15, 4, p. 739-747 9 p.

Research output: Contribution to journalArticle

Magnetic resonance
Embryonic Stem Cells
Stem cells
Transgenes
Magnetic Resonance Imaging
19 Citations (Scopus)

Production of germline transgenic prairie voles (Microtus ochrogaster) using lentiviral vectors

Donaldson, Z. R., Yang, S-H., Chan, A. W. S. & Young, L. J., 2009 Dec 1, In : Biology of Reproduction. 81, 6, p. 1189-1195 7 p.

Research output: Contribution to journalArticle

Arvicolinae
Green Fluorescent Proteins
Transgenes
Rodentia
Ubiquitin C
2008
97 Citations (Scopus)

Accumulation of N-terminal mutant huntingtin in mouse and monkey models implicated as a pathogenic mechanism in Huntington's disease

Wang, C. E., Tydlacka, S., Orr, A. L., Yang, S-H., Graham, R. K., Hayden, M. R., Li, S., Chan, A. W. S. & Li, X. J., 2008 Aug 22, In : Human Molecular Genetics. 17, 17, p. 2738-2751 14 p.

Research output: Contribution to journalArticle

Huntington Disease
Haplorhini
Phenotype
Neurological Models
Neuropil
7 Citations (Scopus)

Chemical enhancement in embryo development and stem cell derivation from single blastomeres

Lorthongpanich, C., Yang, S-H., Piotrowska-Nitsche, K., Parnpai, R. & Chan, A. W. S., 2008 Dec 1, In : Cloning and Stem Cells. 10, 4, p. 503-512 10 p.

Research output: Contribution to journalArticle

Blastomeres
Embryonic Development
Stem Cells
Mitogen-Activated Protein Kinase 14
Adrenocorticotropic Hormone
30 Citations (Scopus)

Development of single mouse blastomeres into blastocysts, outgrowths and the establishment of embryonic stem cells

Lorthongpanich, C., Yang, S-H., Piotrowska-Nitsche, K., Parnpai, R. & Chan, A. W. S., 2008 Jun 1, In : Reproduction. 135, 6, p. 805-813 9 p.

Research output: Contribution to journalArticle

Blastomeres
Blastocyst
Embryonic Stem Cells
Embryonic Structures
Cell Line

Erratum: Development of single mouse blastomeres into blastocysts, outgrowths and the establishment of embryonic stem cells (Reproduction vol. 135 (6) (808))

Lorthongpanich, C., Yang, S. H., Piotrowska-Nitsche, K., Parnpai, R. & Chan, A. W. S., 2008 Aug 1, In : Reproduction. 136, 2, 1 p.

Research output: Contribution to journalComment/debate

Blastomeres
Blastocyst
Embryonic Stem Cells
Reproduction
12 Citations (Scopus)

Lentiviral integration preferences in transgenic mice

Yang, S. H., Cheng, P. H., Sulivan, R. T., Thomas, J. W. & Chan, A. W. S., 2008 Dec 1, In : Genesis. 46, 12, p. 711-718 8 p.

Research output: Contribution to journalArticle

Lentivirus
Transgenic Mice
Genome
CpG Islands
Transcription Initiation Site