• 1319 Citations
  • 19 h-Index
20052020

Research output per year

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Research Output

2020

FGF9 induces functional differentiation to Schwann cells from human adipose derived stem cells

Huang, C. W., Lu, S. Y., Huang, T. C., Huang, B. M., Sunny Sun, H., Yang, S. H., Chuang, J. I., Hsueh, Y. Y., Wu, Y. T. & Wu, C. C., 2020 Jan 1, In : Theranostics. 10, 6, p. 2817-2831 15 p.

Research output: Contribution to journalArticle

Open Access
2019
6 Citations (Scopus)

Lactoferrin Protects Hyperoxia-Induced Lung and Kidney Systemic Inflammation in an In Vivo Imaging Model of NF-κB/Luciferase Transgenic Mice

Yen, C. C., Chang, W. H., Tung, M. C., Chen, H. L., Liu, H. C., Liao, C. H., Lan, Y. W., Chong, K. Y., Yang, S. H. & Chen, C. M., 2019 Jan 1, In : Molecular Imaging and Biology.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2018

FGF9/FGFR2 increase cell proliferation by activating ERK1/2, Rb/E2F1, and cell cycle pathways in mouse Leydig tumor cells

Chang, M. M., Lai, M. S., Hong, S. Y., Pan, B. S., Huang, H., Yang, S. H., Wu, C. C., Sun, H. S., Chuang, J. I., Wang, C. Y. & Huang, B. M., 2018 Nov, In : Cancer Science. 109, 11, p. 3503-3518 16 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Fibroblast Growth Factor 9 Suppresses Striatal Cell Death Dominantly Through ERK Signaling in Huntington's Disease

Yusuf, I. O., Cheng, P. H., Chen, H. M., Chang, Y. F., Chang, C. Y., Yang, H. I., Lin, C. W., Tsai, S. J., Chuang, J. I., Wu, C. C., Huang, B. M., Sun, H. S. & Yang, S. H., 2018 Aug 1, In : Cellular Physiology and Biochemistry. 48, 2, p. 605-617 13 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2017

A novel osteoporosis model with ascorbic acid deficiency in Akr1A1 gene knockout mice

Lai, C. W., Chen, H. L., Tu, M. Y., Lin, W. Y., Röhrig, T., Yang, S. H., Lan, Y. W., Chong, K. Y. & Chen, C. M., 2017 Jan 1, In : Oncotarget. 8, 5, p. 7357-7369 13 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

CCAAT/enhancer-binding protein delta promotes intracellular lipid accumulation in M1 macrophages of vascular lesions

Lai, H., Hsu, L., Tsai, H., Lo, Y., Yang, S., Liu, P. & Wang, Y-M., 2017 Sep 1, In : Cardiovascular Research. 113, 11, p. 1376-1388

Research output: Contribution to journalArticle

CCAAT/enhancer-binding protein delta promotes intracellular lipid accumulation in M1 macrophages of vascular lesions

Lai, H. Y., Hsu, L. W., Tsai, H. H., Lo, Y-C., Yang, S-H., Liu, P-Y. & Wang, J-M., 2017 Jan 1, In : Cardiovascular Research. 113, 11, p. 1376-1388 13 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

miR-196a enhances neuronal morphology through suppressing RANBP10 to provide neuroprotection in Huntington's disease

Her, L. S., Mao, S. H., Chang, C. Y., Cheng, P. H., Chang, Y. F., Yang, H. I., Chen, C. M. & Yang, S. H., 2017 Jan 1, In : Theranostics. 7, 9, p. 2452-2462 11 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

The truncated C-terminal fragment of mutant ATXN3 disrupts mitochondria dynamics in spinocerebellar ataxia type 3 models

Hsu, J. Y., Jhang, Y. L., Cheng, P. H., Chang, Y. F., Mao, S. H., Yang, H. I., Lin, C. W., Chen, C. M. & Yang, S. H., 2017 Jun 20, In : Frontiers in Molecular Neuroscience. 10, 196.

Research output: Contribution to journalArticle

10 Citations (Scopus)
2016

Lentiviral transgenesis in mice via a simple method of viral concentration

Cheng, P. H., Chang, Y. F., Mao, S. H., Lin, H. L., Chen, C. M. & Yang, S. H., 2016 Mar 31, In : Theriogenology. 86, 6, p. 1427-1435 9 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Myostatin propeptide gene delivery by gene gun ameliorates muscle atrophy in a rat model of botulinum toxin-induced nerve denervation

Tsai, S. W., Tung, Y. T., Chen, H. L., Yang, S. H., Liu, C. Y., Lu, M., Pai, H. J., Lin, C. C. & Chen, C. M., 2016 Feb 1, In : Life Sciences. 146, p. 15-23 9 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Sexually Dimorphic Expression of eGFP Transgene in the Akr1A1 Locus of Mouse Liver Regulated by Sex Hormone-Related Epigenetic Remodeling

Lai, C. W., Chen, H. L., Tsai, T. C., Chu, T. W., Yang, S. H., Chong, K. Y. & Chen, C. M., 2016 Apr 18, In : Scientific reports. 6, 24023.

Research output: Contribution to journalArticle

4 Citations (Scopus)

The expression profiles of fibroblast growth factor 9 and its receptors in developing mice testes

Lai, M. S., Wang, C. Y., Yang, S. H., Wu, C. C., Sun, H. S., Tsai, S. J., Chuang, J. I., Chen, Y. C. & Huang, B. M., 2016 Apr 2, In : Organogenesis. 12, 2, p. 61-77 17 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Using Dual Fluorescence Reporting Genes to Establish an In Vivo Imaging Model of Orthotopic Lung Adenocarcinoma in Mice

Lai, C. W., Chen, H. L., Yen, C. C., Wang, J. L., Yang, S. H. & Chen, C. M., 2016 Dec 1, In : Molecular Imaging and Biology. 18, 6, p. 849-859 11 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)
2015

Coordination of AUF1 and miR-148a destabilizes DNA methyltransferase 1 mRNA under hypoxia in endometriosis

Hsiao, K. Y., Wu, M. H., Chang, N., Yang, S. H., Wu, C. W., Sun, H. S. & Tsai, S. J., 2015 May 28, In : Molecular Human Reproduction. 21, 12, p. 894-904 11 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Early Parkinson's disease symptoms in α-synuclein transgenic monkeys

Niu, Y., Guo, X., Chen, Y., Wang, C. E., Gao, J., Yang, W., Kang, Y., Si, W., Wang, H., Yang, S-H., Li, S., Ji, W. & Li, X. J., 2015 Apr 15, In : Human Molecular Genetics. 24, 8, p. 2308-2317 10 p., ddu748.

Research output: Contribution to journalArticle

37 Citations (Scopus)

Extracellular superoxide dismutase ameliorates streptozotocin-induced rat diabetic nephropathy via inhibiting the ROS/ERK1/2 signaling

Kuo, C. W., Shen, C. J., Tung, Y. T., Chen, H. L., Chen, Y. H., Chang, W. H., Cheng, K. C., Yang, S. H. & Chen, C. M., 2015 Jun 22, In : Life Sciences. 135, p. 77-86 10 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)
19 Citations (Scopus)

Functional disruption of the dystrophin gene in rhesus monkey using CRISPR/Cas9

Chen, Y., Zheng, Y., Kang, Y., Yang, W., Niu, Y., Guo, X., Tu, Z., Si, C., Wang, H., Xing, R., Pu, X., Yang, S. H., Li, S., Ji, W. & Li, X. J., 2015 Jul 1, In : Human Molecular Genetics. 24, 13, p. 3764-3774 11 p., ddv120.

Research output: Contribution to journalArticle

109 Citations (Scopus)

MicroRNA-145 as one negative regulator of astrogliosis

Wang, C. Y., Yang, S. H. & Tzeng, S. F., 2015 Feb 1, In : GLIA. 63, 2, p. 194-205 12 p.

Research output: Contribution to journalArticle

50 Citations (Scopus)

SMN is required for the maintenance of embryonic stem cells and neuronal differentiation in mice

Chang, W. F., Xu, J., Chang, C. C., Yang, S. H., Li, H. Y., Hsieh-Li, H. M., Tsai, M. H., Wu, S. C., Cheng, W. T. K., Liu, J. L. & Sung, L. Y., 2015 May 1, In : Brain Structure and Function. 220, 3, p. 1539-1553 15 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Stem cell transplantation therapy in Parkinson’s disease

Fu, M. H., Li, C. L., Lin, H. L., Chen, P. C., Calkins, M. J., Chang, Y. F., Cheng, P. H. & Yang, S. H., 2015 Dec 1, In : SpringerPlus. 4, 1, 597.

Research output: Contribution to journalReview article

19 Citations (Scopus)

Synergy of endothelial and neural progenitor cells from adipose-derived stem cells to preserve neurovascular structures in rat hypoxic-ischemic brain injury

Hsueh, Y. Y., Chang, Y. J., Huang, C. W., Handayani, F., Chiang, Y. L., Fan, S. C., Ho, C. J., Kuo, Y. M., Yang, S. H., Chen, Y. L., Lin, S. C., Huang, C. C. & Wu, C. C., 2015 Oct 8, In : Scientific reports. 5, 14985.

Research output: Contribution to journalArticle

15 Citations (Scopus)

The Differential Profiling of Ubiquitin-Proteasome and Autophagy Systems in Different Tissues before the Onset of Huntington's Disease Models

Her, L. S., Lin, J. Y., Fu, M. H., Chang, Y. F., Li, C. L., Tang, T. Y., Jhang, Y. L., Chang, C. Y., Shih, M. C., Cheng, P. H. & Yang, S. H., 2015 Jul 1, In : Brain Pathology. 25, 4, p. 481-490 10 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

The potential regulatory mechanisms of MIR-196a in huntington's disease through bioinformatic analyses

Fu, M. H., Li, C. L., Lin, H. L., Tsai, S. J., Lai, Y. Y., Chang, Y. F., Cheng, P. H., Chen, C. M. & Yang, S. H., 2015 Sep 16, In : PloS one. 10, 9, A1247.

Research output: Contribution to journalArticle

16 Citations (Scopus)
2014

Lactoferrin protects against chemical-induced rat liver fibrosis by inhibiting stellate cell activation

Tung, Y. T., Tang, T. Y., Chen, H. L., Yang, S. H., Chong, K. Y., Cheng, W. T. K. & Chen, C. M., 2014 Jun, In : Journal of Dairy Science. 97, 6, p. 3281-3291 11 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Recombinant derp5 allergen with αS1-casein signal peptide secreted in murine milk protects against dust mite allergen-induced airway inflammation

Liu, H. C., Pai, S. Y., Chen, H. L., Lai, C. W., Tsai, T. C., Cheng, W. T. K., Yang, S. H. & Chen, C. M., 2014 Nov 1, In : Journal of Dairy Science. 97, 11, p. 6792-6803 12 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2013

Ingestion of milk containing the Dp2 peptide, a dust mite allergen, protects mice from allergic airway inflammation and hyper-responsiveness

Liu, H. C., Pai, S. Y., Cheng, W. T. K., Chen, H. L., Tsai, T. C., Yang, S. H. & Chen, C. M., 2013 Jun 13, In : Allergy, Asthma and Clinical Immunology. 9, 1, 21.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Longitudinal transcriptomic dysregulation in the peripheral blood of transgenic Huntington's disease monkeys

Kocerha, J., Liu, Y., Willoughby, D., Chidamparam, K., Benito, J., Nelson, K., Xu, Y., Chi, T., Engelhardt, H., Moran, S., Yang, S. H., Li, S. H., Li, X. J., Larkin, K., Neumann, A., Banta, H., Yang, J. J. & Chan, A. W. S., 2013 Aug 17, In : BMC Neuroscience. 14, 88.

Research output: Contribution to journalArticle

12 Citations (Scopus)

MiR-196a ameliorates phenotypes of huntington disease in cell, transgenic mouse, and induced pluripotent stem cell models

Cheng, P. H., Li, C. L., Chang, Y. F., Tsai, S. J., Lai, Y. Y., Chan, A. W. S., Chen, C. M. & Yang, S. H., 2013 Aug 8, In : American Journal of Human Genetics. 93, 2, p. 306-312 7 p.

Research output: Contribution to journalArticle

50 Citations (Scopus)

Overexpression of Smad proteins, especially Smad7, in oral epithelial dysplasias

Chen, Y. K., Huang, A. H. C., Cheng, P. H., Yang, S-H. & Lin, L. M., 2013 Jan 1, In : Clinical Oral Investigations. 17, 3, p. 921-932 12 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Significantly differential diffusion of neuropathological aggregates in the brain of transgenic mice carrying N-terminal mutant huntingtin fused with green fluorescent protein

Cheng, P. H., Li, C. L., Her, L. S., Chang, Y. F., Chan, A. W. S., Chen, C. M. & Yang, S. H., 2013 Jan 1, In : Brain Structure and Function. 218, 1, p. 283-294 12 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Therapeutic potential of andrographolide isolated from the leaves of andrographis paniculata nees for treating lung adenocarcinomas

Tung, Y. T., Chen, H. L., Tsai, H. C., Yang, S. H., Chang, Y. C. & Chen, C. M., 2013 Sep 3, In : Evidence-based Complementary and Alternative Medicine. 2013, 305898.

Research output: Contribution to journalArticle

13 Citations (Scopus)
2012

Differential differences in methylation status of putative imprinted genes among cloned swine genomes

Shen, C. J., Cheng, W. T. K., Wu, S. C., Chen, H. L., Tsai, T. C., Yang, S. H. & Chen, C. M., 2012 Feb 29, In : PloS one. 7, 2, e32812.

Research output: Contribution to journalArticle

21 Citations (Scopus)
78 Citations (Scopus)
2011
8 Citations (Scopus)

Characterization of dental pulp stem/stromal cells of Huntington monkey tooth germs

Snyder, B. R., Cheng, P. H., Yang, J., Yang, S. H., Huang, A. H. C. & Chan, A. W. S., 2011 Sep 12, In : BMC Cell Biology. 12, 39.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Transgenic animal models of huntington's disease

Yang, S. H. & Chan, A. W. S., 2011 Dec 1, Molecular and Functional Models in NeuropsychiatrY. Hagan, J. J. (ed.). 1 ed. p. 61-85 25 p. (Current Topics in Behavioral Neurosciences; vol. 7, no. 1).

Research output: Chapter in Book/Report/Conference proceedingChapter

20 Citations (Scopus)
2010

Granzyme G is expressed in the two-cell stage mouse embryo and is required for the maternal-zygotic transition

Tsai, T. C., Lin, W., Yang, S. H., Cheng, W. T. K., Cheng, E. H., Lee, M. S., Chong, K. Y. & Chen, C. M., 2010 Aug 16, In : BMC Developmental Biology. 10, 88.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Monkey hybrid stem cells develop cellular features of Huntington's disease

Laowtammathron, C., Cheng, E. C. H., Cheng, P. H., Snyder, B. R., Yang, S. H., Johnson, Z., Lorthongpanich, C., Kuo, H. C., Parnpai, R. & Chan, A. W. S., 2010 Feb 5, In : BMC Cell Biology. 11, 12.

Research output: Contribution to journalArticle

15 Citations (Scopus)
2009

Assisted fertilization and embryonic axis formation in higher primates

Piotrowska-Nitsche, K., Yang, S. H., Banta, H. & Chan, A. W. S., 2009 Mar, In : Reproductive BioMedicine Online. 18, 3, p. 382-390 9 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Generation of transgenic monkeys with human inherited genetic disease

Chan, A. W. S. & Yang, S. H., 2009 Sep 1, In : Methods. 49, 1, p. 78-84 7 p.

Research output: Contribution to journalReview article

31 Citations (Scopus)

Noninvasive monitoring of embryonic stem cells in vivo with MRI transgene reporter

Liu, J., Cheng, E. C. H., Long, R. C., Yang, S. H., Wang, L., Cheng, P. H., Yang, J., Wu, D., Mao, H. & Chan, A. W. S., 2009 Dec 1, In : Tissue Engineering - Part C: Methods. 15, 4, p. 739-747 9 p.

Research output: Contribution to journalArticle

59 Citations (Scopus)

Production of germline transgenic prairie voles (Microtus ochrogaster) using lentiviral vectors

Donaldson, Z. R., Yang, S-H., Chan, A. W. S. & Young, L. J., 2009 Dec 1, In : Biology of Reproduction. 81, 6, p. 1189-1195 7 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)
2008

Accumulation of N-terminal mutant huntingtin in mouse and monkey models implicated as a pathogenic mechanism in Huntington's disease

Wang, C. E., Tydlacka, S., Orr, A. L., Yang, S. H., Graham, R. K., Hayden, M. R., Li, S., Chan, A. W. S. & Li, X. J., 2008 Aug 22, In : Human Molecular Genetics. 17, 17, p. 2738-2751 14 p.

Research output: Contribution to journalArticle

100 Citations (Scopus)

Chemical enhancement in embryo development and stem cell derivation from single blastomeres

Lorthongpanich, C., Yang, S-H., Piotrowska-Nitsche, K., Parnpai, R. & Chan, A. W. S., 2008 Dec 1, In : Cloning and Stem Cells. 10, 4, p. 503-512 10 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Development of single mouse blastomeres into blastocysts, outgrowths and the establishment of embryonic stem cells

Lorthongpanich, C., Yang, S. H., Piotrowska-Nitsche, K., Parnpai, R. & Chan, A. W. S., 2008 Jun 1, In : Reproduction. 135, 6, p. 805-813 9 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

Erratum: Development of single mouse blastomeres into blastocysts, outgrowths and the establishment of embryonic stem cells (Reproduction vol. 135 (6) (808))

Lorthongpanich, C., Yang, S. H., Piotrowska-Nitsche, K., Parnpai, R. & Chan, A. W. S., 2008 Aug 1, In : Reproduction. 136, 2, 1 p.

Research output: Contribution to journalComment/debate