Shaw-Jenq Tsai

Professor

  • 4255 Citations
  • 39 h-Index
1992 …2019
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Research Output 1992 2019

2011
52 Citations (Scopus)

Suppression of dual-specificity phosphatase-2 by hypoxia increases chemoresistance and malignancy in human cancer cells

Lin, S. C., Chien, C. W., Lee, J. C., Yeh, Y. C., Hsu, K. F., Lai, Y. Y., Lin, S. C. & Tsai, S. J., 2011 May 2, In : Journal of Clinical Investigation. 121, 5, p. 1905-1916 12 p.

Research output: Contribution to journalArticle

Dual Specificity Phosphatase 2
Hypoxia-Inducible Factor 1
Neoplasms
Dual Specificity Phosphatase 1
Hypoxia
69 Citations (Scopus)

Targeted methylation of two tumor suppressor genes is sufficient to transform mesenchymal stem cells into cancer stem/initiating cells

Teng, I. W., Hou, P. C., Lee, K. D., Chu, P. Y., Yeh, K. T., Jin, V. X., Tseng, M. J., Tsai, S. J., Chang, Y. S., Wu, C. S., Sun, H. S., Tsai, K. D., Jeng, L. B., Nephew, K. P., Huang, T. H. M., Hsiao, S. H. & Leu, Y. W., 2011 Jul 1, In : Cancer Research. 71, 13, p. 4653-4663 11 p.

Research output: Contribution to journalArticle

Neoplastic Stem Cells
Tumor Suppressor Genes
Mesenchymal Stromal Cells
Methylation
Adult Stem Cells
4 Citations (Scopus)

Using unsupervised patterns to extract gene regulation relationships for network construction

Tang, Y. T., Li, S. J., Kao, H. Y., Tsai, S. J. & Wang, H. C., 2011 May 17, In : PloS one. 6, 5, e19633.

Research output: Contribution to journalArticle

Gene expression
Gene Expression
gene expression
extracts
Genes
2010
20 Citations (Scopus)

AUF1 p42 isoform selectively controls both steady-state and PGE2-induced FGF9 mRNA decay

Chen, T. M., Hsu, C. H., Tsai, S. J. & Sun, H. S., 2010 Dec 1, In : Nucleic acids research. 38, 22, p. 8061-8071 11 p.

Research output: Contribution to journalArticle

Fibroblast Growth Factor 9
RNA Stability
Dinoprostone
Protein Isoforms
AU Rich Elements
41 Citations (Scopus)

DNA methylation of the Trip10 promoter accelerates mesenchymal stem cell lineage determination

Hsiao, S. H., Lee, K. D., Hsu, C. C., Tseng, M. J., Jin, V. X., Sun, W. S., Hung, Y. C., Yeh, K. T., Yan, P. S., Lai, Y. Y., Sun, H. S., Lu, Y. J., Chang, Y. S., Tsai, S. J., Huang, T. H. M. & Leu, Y. W., 2010 Sep 1, In : Biochemical and Biophysical Research Communications. 400, 3, p. 305-312 8 p.

Research output: Contribution to journalArticle

Cell Lineage
DNA Methylation
Stem cells
Mesenchymal Stromal Cells
Methylation
29 Citations (Scopus)

Fibroblast growth factor 9 stimulates steroidogenesis in postnatal Leydig cells

Lin, Y. M., Tsai, C. C., Chung, C. L., Chen, P. R., Sunny Sun, H., Tsai, S. J. & Huang, B. M., 2010 Jun 1, In : International Journal of Andrology. 33, 3, p. 545-553 9 p.

Research output: Contribution to journalArticle

Fibroblast Growth Factor 9
Leydig Cells
Testosterone
Gonadal Dysgenesis
Disorders of Sex Development
58 Citations (Scopus)

Inhibition of CD36-dependent phagocytosis by prostaglandin E2 contributes to the development of endometriosis

Chuang, P. C., Lin, Y. J., Wu, M-H., Wing, L. Y. C., Shoji, Y. & Tsai, S-J., 2010 Jan 1, In : American Journal of Pathology. 176, 2, p. 850-860 11 p.

Research output: Contribution to journalArticle

Endometriosis
Phagocytosis
Dinoprostone
Peritoneal Macrophages
Macrophages
16 Citations (Scopus)

Leptin on peritoneal macrophages of patients with endometriosis

Wu, M-H., Huang, M. F., Chang, F. M. & Tsai, S-J., 2010 Mar 1, In : American Journal of Reproductive Immunology. 63, 3, p. 214-221 8 p.

Research output: Contribution to journalArticle

Peritoneal Macrophages
Endometriosis
Leptin
Ascitic Fluid
Dinoprost
79 Citations (Scopus)

Prostaglandin E2: The master of endometriosis?

Wu, M-H., Lu, C. W., Chuang, P. C. & Tsai, S-J., 2010 Jun 1, In : Experimental Biology and Medicine. 235, 6, p. 668-677 10 p.

Research output: Contribution to journalShort survey

Endometriosis
Dinoprostone
Eicosanoids
Cell proliferation
Prostaglandins E
28 Citations (Scopus)

Testosterone synthesized in cultured human SZ95 sebocytes derives mainly from dehydroepiandrosterone

Chen, W. C., Tsai, S. J., Sheu, H. M., Tsai, J. C. & Zouboulis, C. C., 2010 May 1, In : Experimental Dermatology. 19, 5, p. 470-472 3 p.

Research output: Contribution to journalLetter

Dehydroepiandrosterone
Testosterone
Androgens
Fibroblast Growth Factor 9
3-Hydroxysteroid Dehydrogenases
2009
4 Citations (Scopus)

CDC25 protein expression and interaction with DAZL in human corpus luteum

Pan, H. A., Lee, Y. C., Teng, Y. N., Tsai, S. J., Lin, Y. M. & Kuo, P. L., 2009 Dec 1, In : Fertility and Sterility. 92, 6, p. 1997-2003 7 p.

Research output: Contribution to journalArticle

Azoospermia
Corpus Luteum
Luteal Cells
Proteins
Luteal Phase
52 Citations (Scopus)

Downregulation of CD36 results in reduced phagocytic ability of peritoneal macrophages of women with endometriosis

Chuang, P. C., Wu, M-H., Shoji, Y. & Tsai, S-J., 2009 Oct 1, In : Journal of Pathology. 219, 2, p. 232-241 10 p.

Research output: Contribution to journalArticle

Peritoneal Macrophages
Endometriosis
Down-Regulation
Macrophages
Immune System
11 Citations (Scopus)
Prostaglandin Receptors
Dinoprostone
Testosterone
Dinoprost
Prostaglandin E Receptors
2008
23 Citations (Scopus)
CCAAT-Enhancer-Binding Proteins
Response Elements
Stromal Cells
Prostaglandins E
Adenosine
16 Citations (Scopus)

Exposure to a mixture of Polychlorinated biphenyls and polychlorinated dibenzofurans resulted in a prolonged time to pregnancy in women

Yang, C. Y., Wang, Y. J., Chen, P. C., Tsai, S. J. & Guo, Y. L., 2008 May, In : Environmental Health Perspectives. 116, 5, p. 599-604 6 p.

Research output: Contribution to journalArticle

Time-to-Pregnancy
Polychlorinated Biphenyls
Fertility
Infertility
Polychlorinated Dibenzofurans
185 Citations (Scopus)

Induction of pyruvate dehydrogenase kinase-3 by hypoxia-inducible factor-1 promotes metabolic switch and drug resistance

Lu, C. W., Lin, S. C., Chen, K. F., Lai, Y. Y. & Tsai, S. J., 2008 Oct 17, In : Journal of Biological Chemistry. 283, 42, p. 28106-28114 9 p.

Research output: Contribution to journalArticle

Hypoxia-Inducible Factor 1
Drug Resistance
Switches
Cells
Assays
45 Citations (Scopus)

Regulation of CD151 by hypoxia controls cell adhesion and metastasis in colorectal cancer

Chien, C. W., Lin, S. C., Lai, Y. Y., Lin, B. W., Lin, S. C., Lee, J. C. & Tsai, S. J., 2008 Dec 15, In : Clinical Cancer Research. 14, 24, p. 8043-8051 9 p.

Research output: Contribution to journalArticle

Cell Adhesion
Colorectal Neoplasms
Neoplasm Metastasis
Neoplasms
Hypoxia-Inducible Factor 1
2007
77 Citations (Scopus)
Hypoxia-Inducible Factor 1
Stromal Cells
Leptin
Endometriosis
Gene Expression
70 Citations (Scopus)

Endometriosis: Disease pathophysiology and the role of prostaglandins

Wu, M. H., Shoji, Y., Chuang, P. C. & Tsai, S. J., 2007 Jan 1, In : Expert Reviews in Molecular Medicine. 9, 2, p. 1-20 20 p.

Research output: Contribution to journalReview article

Endometriosis
Prostaglandins
Public health
Dyspareunia
Dysmenorrhea
4 Citations (Scopus)

Expression of sex-determining genes in the scalp of men with androgenetic alopecia

Chen, W. C., Yang, C. C., Tsai, R. Y., Liao, C. Y., Yen, Y. T., Hung, C. L., Chen, K. F., Tsai, S. J. & Zouboulis, C. C., 2007 Mar 1, In : Dermatology. 214, 3, p. 199-204 6 p.

Research output: Contribution to journalArticle

Alopecia
Scalp
Genes
Messenger RNA
Skin
22 Citations (Scopus)

Microsatellite in the 3' untranslated region of human fibroblast growth factor 9 (FGF9) gene exhibits pleiotropic effect on modulating FGF9 protein expression.

Chen, T. M., Kuo, P-L., Hsu, C. H., Tsai, S-J., Chen, M. J., Lin, C. W. & Sun, H-F., 2007 Jan 1, In : Human mutation. 28, 1, 1 p.

Research output: Contribution to journalArticle

Fibroblast Growth Factor 9
Genetic Pleiotropy
3' Untranslated Regions
Microsatellite Repeats
Proteins
2006
9 Citations (Scopus)

Computational analysis and refinement of sequence structure on chromosome 22q11.2 region: Application to the development of quantitative real-time PCR assay for clinical diagnosis

Chen, Y. F., Kou, P. L., Tsai, S-J., Chen, K. F., Chan, H. H., Chen, C. M. & Sun, H-F., 2006 Feb 1, In : Genomics. 87, 2, p. 290-297 8 p.

Research output: Contribution to journalArticle

Chromosome Structures
Genomic Segmental Duplications
DiGeorge Syndrome
Sequence Analysis
Real-Time Polymerase Chain Reaction
22 Citations (Scopus)

Expression of sex-determining genes in human sebaceous glands and their possible role in the pathogenesis of acne

Chen, W., Yang, C-C., Liao, C. L., Hung, C. L., Tsai, S-J., Chen, K. F., Sheu, H. M. & Zouboulis, C. C., 2006 Aug 1, In : Journal of the European Academy of Dermatology and Venereology. 20, 7, p. 846-852 7 p.

Research output: Contribution to journalArticle

Sebaceous Glands
Acne Vulgaris
Genes
Messenger RNA
Skin
21 Citations (Scopus)

Higher levels of steroidogenic acute regulatory protein and type I 3β-hydroxysteroid dehydrogenase in the scalp of men with androgenetic alopecia [1]

Chen, W. C., Tsai, S. J., Liao, C. Y., Tsai, R. Y., Chen, Y. J., Pan, B. J., Hung, C. L. & Zouboulis, C. C., 2006 Oct 30, In : Journal of Investigative Dermatology. 126, 10, p. 2332-2335 4 p.

Research output: Contribution to journalLetter

17-Hydroxysteroid Dehydrogenases
Hydroxysteroid Dehydrogenases
Phosphoproteins
Alopecia
Scalp
43 Citations (Scopus)

Prostaglandin E2 induces fibroblast growth factor 9 via EPS-dependent protein kinase Cδ and Elk-1 signaling

Chuang, P. C., Sun, H. S., Chen, T. M. & Tsai, S. J., 2006 Nov 1, In : Molecular and Cellular Biology. 26, 22, p. 8281-8292 12 p.

Research output: Contribution to journalArticle

Fibroblast Growth Factor 9
Dinoprostone
Protein Kinase C
Stromal Cells
ets-Domain Protein Elk-1
2005
97 Citations (Scopus)

Distinct regulation of cyclooxygenase-2 by interleukin-1β in normal and endometriotic stromal cells

Wu, M. H., Wang, C. A., Lin, C. C., Chen, L. C., Chang, W. C. & Tsai, S. J., 2005 Jan 1, In : Journal of Clinical Endocrinology and Metabolism. 90, 1, p. 286-295 10 p.

Research output: Contribution to journalArticle

Cyclooxygenase 2
Stromal Cells
Interleukin-1
Endometriosis
RNA Stability
34 Citations (Scopus)
Functional analysis
Leiomyoma
Pituitary Neoplasms
Transforming Growth Factors
Oncogenes
6 Citations (Scopus)

Mild cutaneous manifestation in two young women with extraordinary hyperandrogenemia

Chen, W. C., Chen, G. Y., Tsai, S-J., Wang, P. W., Sheu, H. M., Shen, Y. S. & Chen, F. F., 2005 Jan 1, In : Dermatology. 210, 1, p. 49-52 4 p.

Research output: Contribution to journalArticle

Skin Manifestations
Alopecia
Acne Vulgaris
Testosterone
Hyperandrogenism
64 Citations (Scopus)

Suppression of matrix metalloproteinase-9 by prostaglandin E2 in peritoneal macrophage is associated with severity of endometriosis

Wu, M-H., Shoji, Y., Wu, M. C., Chuang, P. C., Lin, C. C., Huang, M. F. & Tsai, S-J., 2005 Jan 1, In : American Journal of Pathology. 167, 4, p. 1061-1069 9 p.

Research output: Contribution to journalArticle

Matrix Metalloproteinase 9
Peritoneal Macrophages
Endometriosis
Dinoprostone
Macrophages
37 Citations (Scopus)
Fibroblast Growth Factor 9
Phosphatidylinositol 3-Kinase
Ribosomal Protein S6 Kinases
70-kDa Ribosomal Protein S6 Kinases
Cell proliferation
56 Citations (Scopus)

Transcriptional repression of human cad gene by hypoxia inducible factor-1α

Chen, K. F., Lai, Y. Y., Sun, H. S. & Tsai, S. J., 2005 Oct 31, In : Nucleic acids research. 33, 16, p. 5190-5198 9 p.

Research output: Contribution to journalArticle

Hypoxia-Inducible Factor 1
Genes
Response Elements
Dihydroorotase
Aspartate Carbamoyltransferase
2004
19 Citations (Scopus)

Effects of laparoscopic ovarian drilling on young adult women with polycystic ovarian syndrome

Wu, M. H., Huang, M. F., Tsai, S. J., Pan, H. A., Cheng, Y. C. & Lin, Y. S., 2004 May, In : Journal of the American Association of Gynecologic Laparoscopists. 11, 2, p. 184-190 7 p.

Research output: Contribution to journalArticle

Polycystic Ovary Syndrome
Luteinizing Hormone
Young Adult
Leptin
Follicle Stimulating Hormone
27 Citations (Scopus)

Upregulation of Steroidogenic Enzymes and Ovarian 17β-Estradiol in Human Granulosa-Lutein Cells by Cordyceps sinensis Mycelium

Huang, B. M., Hsiao, K. Y., Chuang, P. C., Wu, M. H., Pan, H. A. & Tsai, S. J., 2004 May 1, In : Biology of Reproduction. 70, 5, p. 1358-1364 7 p.

Research output: Contribution to journalArticle

Cordyceps
Luteal Cells
Mycelium
Estradiol
Up-Regulation
2003
93 Citations (Scopus)

Acute reduction in serum progesterone concentrations after feed intake in dairy cows

Vasconcelos, J. L. M., Sangsritavong, S., Tsai, S. J. & Wiltbank, M. C., 2003 Sep 15, In : Theriogenology. 60, 5, p. 795-807 13 p.

Research output: Contribution to journalArticle

blood serum
Progesterone
progesterone
dairy cows
feed intake
47 Citations (Scopus)
Fibroblast Growth Factor 9
Estrogens
Stromal Cells
Estradiol
Fibroblast Growth Factor Receptors
31 Citations (Scopus)

In vivo and in vitro stimulatory effects of Cordyceps sinensis on testosterone production in mouse Leydig cells

Hsu, C. C., Huang, Y. L., Tsai, S. J., Sheu, C. C. & Huang, B. M., 2003 Sep 5, In : Life Sciences. 73, 16, p. 2127-2136 10 p.

Research output: Contribution to journalArticle

Cordyceps
Leydig Cells
Testosterone
Polysaccharides
Water
36 Citations (Scopus)

Regulatory mechanism of Cordyceps sinensis mycelium on mouse Leydig cell steroidogenesis

Hsu, C. C., Tsai, S. J., Huang, Y. L. & Huang, B. M., 2003 May 22, In : FEBS Letters. 543, 1-3, p. 140-143 4 p.

Research output: Contribution to journalArticle

Cordyceps
Staurosporine
Leydig Cells
Mycelium
Mixed Function Oxygenases
11 Citations (Scopus)

The recovery of some components of the renin angiotensin system in the rat pancreas after chronic exposure to hypoxic condition

Ip, S. P., Wong, T. P., Tsai, S. J. & Leung, P. S., 2003 Dec 1, In : Journal of Molecular Endocrinology. 31, 3, p. 563-571 9 p.

Research output: Contribution to journalArticle

Renin-Angiotensin System
Pancreas
Angiotensin Type 1 Receptor
Peptidyl-Dipeptidase A
Polymerase Chain Reaction
39 Citations (Scopus)

Three-dimensional power Doppler imaging of ovarian stromal blood flow in women with endometriosis undergoing in vitro fertilization

Wu, M-H., Tsai, S-J., Pan, H. A., Hsiao, K. Y. & Chang, F. M., 2003 May 1, In : Ultrasound in Obstetrics and Gynecology. 21, 5, p. 480-485 6 p.

Research output: Contribution to journalArticle

fertilization
Endometriosis
Fertilization in Vitro
blood flow
Leptin
82 Citations (Scopus)

Transactivation of steroidogenic acute regulatory protein in human endometriotic stromal cells is mediated by the prostaglandin EP2 receptor

Sun, H. S., Hsiao, K. Y., Hsu, C. C., Wu, M. H. & Tsai, S. J., 2003 Sep 1, In : Endocrinology. 144, 9, p. 3934-3942 9 p.

Research output: Contribution to journalArticle

Prostaglandin Receptors
Stromal Cells
Transcriptional Activation
Cyclic AMP Response Element-Binding Protein
Dinoprostone
2002
34 Citations (Scopus)

Chronic exercise increases both inducible and endothelial nitric oxide synthase gene expression in endothelial cells of rat aorta

Yang, A. L., Tsai, S-J., Jiang, M-J., Jen, C. J. & Chen, H. I., 2002 Apr 6, In : Journal of biomedical science. 9, 2, p. 149-155 7 p.

Research output: Contribution to journalArticle

Nitric Oxide Synthase Type III
Endothelial cells
Nitric Oxide Synthase Type II
Gene expression
Aorta
87 Citations (Scopus)

Distinct mechanisms regulate cyclooxygenase-1 and -2 in peritoneal macrophages of women with and without endometriosis

Wu, M. H., Sun, H. S., Lin, C. C., Hsiao, K. Y., Chuang, P. C., Pan, H. A. & Tsai, S. J., 2002 Dec 1, In : Molecular Human Reproduction. 8, 12, p. 1103-1110 8 p.

Research output: Contribution to journalArticle

Cyclooxygenase 1
Peritoneal Macrophages
Endometriosis
Cyclooxygenase 2
Prostaglandin-Endoperoxide Synthases
Nitric Oxide Synthase Type III
Endothelial cells
Nitric Oxide Synthase Type II
Gene expression
Rats
13 Citations (Scopus)

Expression of DAZL protein in the human corpus luteum

Pan, H. A., Tsai, S-J., Chen, C. W., Lee, Y. C., Lin, Y. & Kuo, P-L., 2002 Jul 20, In : Molecular Human Reproduction. 8, 6, p. 540-545 6 p.

Research output: Contribution to journalArticle

Corpus Luteum
Luteal Cells
Proteins
Luteal Phase
Germ Cells
79 Citations (Scopus)

Fibroblast growth factor-9 is an endometrial stromal growth factor

Tsai, S. J., Wu, M. H., Chen, H. M., Chuang, P. C. & Wing, L. Y. C., 2002 Jan 1, In : Endocrinology. 143, 7, p. 2715-2721 7 p.

Research output: Contribution to journalArticle

Fibroblast Growth Factor 9
Intercellular Signaling Peptides and Proteins
Stromal Cells
Estradiol
Epithelial Cells
69 Citations (Scopus)
Endometriosis
Stromal Cells
Leptin
Up-Regulation
Cell Proliferation
24 Citations (Scopus)

Presence of DAZL transcript and protein in mature human spermatozoa

Lin, Y., Chen, C. W., Sun, H-F., Tsai, S-J., Lin, J. S. N. & Kuo, P-L., 2002 Mar 9, In : Fertility and Sterility. 77, 3, p. 626-629 4 p.

Research output: Contribution to journalArticle

Spermatozoa
Staining and Labeling
Proteins
Western Blotting
Sperm-Ovum Interactions
102 Citations (Scopus)

Regulation of progesterone and prostaglandin F production in the CL

Diaz, F. J., Anderson, L. E., Wu, Y. L., Rabot, A., Tsai, S-J. & Wiltbank, M. C., 2002 May 31, In : Molecular and Cellular Endocrinology. 191, 1, p. 65-80 16 p.

Research output: Contribution to journalArticle

Dinoprost
Luteal Cells
Corpus Luteum
Progesterone
Luteinization
2001
17 Citations (Scopus)

Differential effects of prostaglandin F on in vitro luteinized bovine granulosa cells

Tsai, S-J. & Wiltbank, M. C., 2001 Jan 1, In : Reproduction. 122, 2, p. 245-253 9 p.

Research output: Contribution to journalArticle

Dinoprost
Granulosa Cells
Cyclooxygenase 2
Colforsin
Messenger RNA