Shaw-Jenq Tsai

Professor

  • 4039 Citations
  • 39 h-Index
1992 …2019
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Research Output 1992 2019

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Article
2019
1 Citation (Scopus)

Fibroblast growth factor 9 activates anti-oxidative functions of Nrf2 through ERK signalling in striatal cell models of Huntington's disease

Yusuf, I. O., Chen, H. M., Cheng, P. H., Chang, C. Y., Tsai, S-J., Chuang, J-I., Wu, C-C., Huang, B-M., Sun, H-F. & Yang, S-H., 2019 Jan 1, In : Free Radical Biology and Medicine. 130, p. 256-266 11 p.

Research output: Contribution to journalArticle

Fibroblast Growth Factor 9
Corpus Striatum
Huntington Disease
Oxidative stress
Oxidative Stress

hnRNPM induces translation switch under hypoxia to promote colon cancer development

Chen, T. M., Lai, M. C., Li, Y. H., Chan, Y. L., Wu, C. H., Wang, Y. M., Chien, C. W., Huang, S. Y., Sun, H-F. & Tsai, S-J., 2019 Mar 1, In : EBioMedicine. 41, p. 299-309 11 p.

Research output: Contribution to journalArticle

Open Access
Colonic Neoplasms
Genes
Switches
Carcinogenesis
Proteins
1 Citation (Scopus)

Hypoxia: The force of endometriosis

Wu, M-H., Hsiao, K. Y. & Tsai, S-J., 2019 Mar 1, In : Journal of Obstetrics and Gynaecology Research. 45, 3, p. 532-541 10 p.

Research output: Contribution to journalArticle

Endometriosis
Gene Regulatory Networks
Uterus
Medical Electronics
Peritoneum
1 Citation (Scopus)
Cell Hypoxia
Stromal Cells
Apoptosis
Endometriosis
Oxygen Consumption
1 Citation (Scopus)

Targeting anthrax toxin receptor 2 ameliorates endometriosis progression

Lin, S-C., Lee, H. C., Hsu, C. T., Huang, Y. H., Li, W. N., Hsu, P. L., Wu, M-H. & Tsai, S-J., 2019 Jan 1, In : Theranostics. 9, 3, p. 620-632 13 p.

Research output: Contribution to journalArticle

Open Access
Endometriosis
Histone Code
Choristoma
Pathologic Processes
Stromal Cells
2018
3 Citations (Scopus)

Fibroblast Growth Factor 9 Suppresses Striatal Cell Death Dominantly Through ERK Signaling in Huntington's Disease

Yusuf, I. O., Cheng, P. H., Chen, H. M., Chang, Y. F., Chang, C. Y., Yang, H. I., Lin, C. W., Tsai, S-J., Chuang, J-I., Wu, C-C., Huang, B-M., Sun, H-F. & Yang, S-H., 2018 Aug 1, In : Cellular Physiology and Biochemistry. 48, 2, p. 605-617 13 p.

Research output: Contribution to journalArticle

Fibroblast Growth Factor 9
Corpus Striatum
Huntington Disease
Cell Death
MAP Kinase Signaling System
3 Citations (Scopus)

Suppression of COUP-TFII upregulates angiogenin and promotes angiogenesis in endometriosis

Fu, J. L., Hsiao, K. Y., Lee, H. C., Li, W. N., Chang, N., Wu, M-H. & Tsai, S-J., 2018 Jan 1, In : Human Reproduction. 33, 8, p. 1517-1527 11 p.

Research output: Contribution to journalArticle

COUP Transcription Factor II
Endometriosis
Up-Regulation
Stromal Cells
Down-Regulation
2017
17 Citations (Scopus)

Hypoxia-induced downregulation of DUSP-2 phosphatase drives colon cancer stemness

Hou, P. C., Li, Y. H., Lin, S-C., Lin, S-C., Lee, J-C., Lin, P-W., Liou, J. P., Chang, J-Y., Kuo, C. C., Liu, Y. M., Sun, H-F. & Tsai, S-J., 2017 Aug 15, In : Cancer Research. 77, 16, p. 4305-4316 12 p.

Research output: Contribution to journalArticle

Dual-Specificity Phosphatases
Dual Specificity Phosphatase 2
Colonic Neoplasms
Down-Regulation
Neoplasms
6 Citations (Scopus)

Hypoxia-inhibited DUSP2 expression promotes IL-6/STAT3 signaling in endometriosis

Hsiao, K. Y., Chang, N., Tsai, J. L., Lin, S-C., Tsai, S-J. & Wu, M-H., 2017 Jan 1, In : American Journal of Reproductive Immunology. 78, 4, e12690.

Research output: Contribution to journalArticle

Dual Specificity Phosphatase 2
Endometriosis
Interleukin-6
Stromal Cells
Bromodeoxyuridine
11 Citations (Scopus)

Loss of dual-specificity phosphatase-2 promotes angiogenesis and metastasis via up-regulation of interleukin-8 in colon cancer

Lin, S-C., Hsiao, K. Y., Chang, N., Hou, P. C. & Tsai, S-J., 2017 Apr 1, In : Journal of Pathology. 241, 5, p. 638-648 11 p.

Research output: Contribution to journalArticle

Dual Specificity Phosphatase 2
Interleukin-8
Colonic Neoplasms
Up-Regulation
Neoplasm Metastasis
155 Citations (Scopus)

Noncoding effects of circular RNA CCDC66 promote colon cancer growth and metastasis

Hsiao, K. Y., Lin, Y. C., Gupta, S. K., Chang, N., Yen, L., Sun, H-F. & Tsai, S-J., 2017 May 1, In : Cancer Research. 77, 9, p. 2339-2350 12 p.

Research output: Contribution to journalArticle

Colonic Neoplasms
Neoplasm Metastasis
Growth
Neoplasms
Colorectal Neoplasms
5 Citations (Scopus)

Targeting hypoxia-mediated YAP1 nuclear translocation ameliorates pathogenesis of endometriosis without compromising maternal fertility

Lin, S-C., Lee, H. C., Hou, P. C., Fu, J. L., Wu, M-H. & Tsai, S-J., 2017 Aug 1, In : Journal of Pathology. 242, 4, p. 476-487 12 p.

Research output: Contribution to journalArticle

Endometriosis
Nuclear Proteins
Fertility
Mothers
Proteins
2016
28 Citations (Scopus)

Dysregulation of miRNAs-COUP-TFII-FOXM1-CENPF axis contributes to the metastasis of prostate cancer

Lin, S-C., Kao, C. Y., Lee, H. J., Creighton, C. J., Ittmann, M. M., Tsai, S-J., Tsai, S. Y. & Tsai, M. J., 2016 Apr 25, In : Nature communications. 7, 11418.

Research output: Contribution to journalArticle

metastasis
MicroRNAs
Prostatic Neoplasms
cancer
Neoplasm Metastasis
14 Citations (Scopus)

Targeting TYRO3 inhibits epithelial-mesenchymal transition and increases drug sensitivity in colon cancer

Chien, C. W., Hou, P. C., Wu, H. C., Chang, Y. L., Lin, S-C., Lin, S-C., Lin, P-W., Lee, J-C., Chang, Y. J., Sun, H-F. & Tsai, S-J., 2016 Nov 10, In : Oncogene. 35, 45, p. 5872-5881 10 p.

Research output: Contribution to journalArticle

Epithelial-Mesenchymal Transition
Colonic Neoplasms
Pharmaceutical Preparations
Oncogenes
Antibodies
3 Citations (Scopus)

The expression profiles of fibroblast growth factor 9 and its receptors in developing mice testes

Lai, M. S., Wang, C-Y., Yang, S-H., Wu, C-C., Sun, H-F., Tsai, S-J., Chuang, J-I., Chen, Y. C. & Huang, B-M., 2016 Apr 2, In : Organogenesis. 12, 2, p. 61-77 17 p.

Research output: Contribution to journalArticle

Fibroblast Growth Factor 9
Fibroblasts
Testis
Spermatids
Leydig Cells
2015
7 Citations (Scopus)
Human Genome
Genome
Genes
Gene
Transcription Initiation Site
20 Citations (Scopus)

Coordination of AUF1 and miR-148a destabilizes DNA methyltransferase 1 mRNA under hypoxia in endometriosis

Hsiao, K. Y., Wu, M-H., Chang, N., Yang, S-H., Wu, C. W., Sun, H-F. & Tsai, S-J., 2015 May 28, In : Molecular Human Reproduction. 21, 12, p. 894-904 11 p.

Research output: Contribution to journalArticle

Methyltransferases
Endometriosis
MicroRNAs
Messenger RNA
DNA
15 Citations (Scopus)
Fibroblast Growth Factor 9
Fibroblast Growth Factor Receptors
Cyclic AMP Response Element-Binding Protein
Heme Oxygenase-1
Oxidation-Reduction
2 Citations (Scopus)

Pathological functions of hypoxia in endometriosis

Hsiao, K. Y., Lin, S-C., Wu, M-H. & Tsai, S-J., 2015 Jan 15, In : Frontiers in Bioscience - Elite. 7E, 2, p. 352-366 15 p.

Research output: Contribution to journalArticle

Endometriosis
Cyclooxygenase 2
Dinoprostone
Estrogens
Genes
9 Citations (Scopus)

The non-canonical role of vascular endothelial growth factor-C axis in cancer progression

Wang, C. A. & Tsai, S-J., 2015 Jun 12, In : Experimental Biology and Medicine. 240, 6, p. 718-724 7 p.

Research output: Contribution to journalArticle

Vascular Endothelial Growth Factor C
Neoplasms
Tumors
Lymph Nodes
Cells
12 Citations (Scopus)

The potential regulatory mechanisms of MIR-196a in huntington's disease through bioinformatic analyses

Fu, M. H., Li, C. L., Lin, H. L., Tsai, S-J., Lai, Y. Y., Chang, Y. F., Cheng, P. H., Chen, C. M. & Yang, S-H., 2015 Sep 16, In : PloS one. 10, 9, A1247.

Research output: Contribution to journalArticle

Huntington Disease
Bioinformatics
cytoskeleton
Computational Biology
Cytoskeleton
2014
Literature
technical literature
Gene expression
Learning
regulation
20 Citations (Scopus)

Fibroblast growth factor 9 activates Akt and MAPK pathways to stimulate steroidogenesis in mouse leydig cells

Lai, M. S., Cheng, Y-S., Chen, P. R., Tsai, S-J. & Huang, B-M., 2014 Mar 6, In : PloS one. 9, 3, e90243.

Research output: Contribution to journalArticle

Fibroblast Growth Factor 9
fibroblast growth factors
steroidogenesis
Leydig cells
Leydig Cells
18 Citations (Scopus)

Hypoxia-regulated gene network in drug resistance and cancer progression

Lin, S-C., Liao, W. L., Lee, J-C. & Tsai, S-J., 2014 Jan 1, In : Experimental Biology and Medicine. 239, 7, p. 779-792 14 p.

Research output: Contribution to journalArticle

Gene Regulatory Networks
Drug Resistance
Tumors
Genes
Pharmaceutical Preparations
13 Citations (Scopus)

Overexpression of FGF9 in colon cancer cells is mediated by hypoxia-induced translational activation

Chen, T. M., Shih, Y. H., Tseng, T-C., Lai, M. C., Wu, C. H., Li, Y. H., Tsai, S-J. & Sun, H-F., 2014 Jan 1, In : Nucleic acids research. 42, 5, p. 2932-2944 13 p.

Research output: Contribution to journalArticle

Fibroblast Growth Factor 9
Colonic Neoplasms
Proteins
Neoplasms
Messenger RNA
14 Citations (Scopus)

Suppression of COUP-TFII by proinflammatory cytokines contributes to the pathogenesis of endometriosis

Lin, S-C., Li, Y. H., Wu, M-H., Chang, Y. F., Lee, D. K., Tsai, S. Y., Tsai, M. J. & Tsai, S-J., 2014 Jan 1, In : Journal of Clinical Endocrinology and Metabolism. 99, 3

Research output: Contribution to journalArticle

COUP Transcription Factor II
Endometriosis
Cytokines
Cyclooxygenase 2
Stromal Cells
2013
46 Citations (Scopus)

Atrial Identity Is Determined by a COUP-TFII Regulatory Network

Wu, S. P., Cheng, C. M., Lanz, R. B., Wang, T., Respress, J. L., Ather, S., Chen, W., Tsai, S-J., Wehrens, X. H. T., Tsai, M. J. & Tsai, S. Y., 2013 May 28, In : Developmental Cell. 25, 4, p. 417-426 10 p.

Research output: Contribution to journalArticle

Genes
Cardiac Myocytes
Atrial Function
Chromatin Immunoprecipitation
Ablation
92 Citations (Scopus)

COUP-TFII inhibits TGF-β-induced growth barrier to promote prostate tumorigenesis

Qin, J., Wu, S. P., Creighton, C. J., Dai, F., Xie, X., Cheng, C. M., Frolov, A., Ayala, G., Lin, X., Feng, X. H., Ittmann, M. M., Tsai, S-J., Tsai, M. J. & Tsai, S. Y., 2013 Jan 10, In : Nature. 493, 7431, p. 236-240 5 p.

Research output: Contribution to journalArticle

Transforming Growth Factors
Phosphoric Monoester Hydrolases
Prostate
Carcinogenesis
Growth
24 Citations (Scopus)

Human DDX3 Interacts with the HIV-1 Tat Protein to Facilitate Viral mRNA Translation

Lai, M. C., Wang, S-W., Cheng, L., Tarn, W. Y., Tsai, S-J. & Sun, H-F., 2013 Jul 1, In : PloS one. 8, 7, e68665.

Research output: Contribution to journalArticle

Human Immunodeficiency Virus tat Gene Products
tat Gene Products
Protein Biosynthesis
Human immunodeficiency virus 1
translation (genetics)
86 Citations (Scopus)

In silico identification of oncogenic potential of fyn-related kinase in hepatocellular carcinoma

Chen, J. S., Hung, W. S., Chan, H. H., Tsai, S-J. & Sun, H-F., 2013 Feb 15, In : Bioinformatics. 29, 4, p. 420-427 8 p.

Research output: Contribution to journalArticle

Computer Simulation
Hepatocellular Carcinoma
Phosphotransferases
Genes
Cancer
47 Citations (Scopus)

MiR-196a ameliorates phenotypes of huntington disease in cell, transgenic mouse, and induced pluripotent stem cell models

Cheng, P. H., Li, C. L., Chang, Y. F., Tsai, S-J., Lai, Y. Y., Chan, A. W. S., Chen, C. M. & Yang, S-H., 2013 Aug 8, In : American Journal of Human Genetics. 93, 2, p. 306-312 7 p.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Huntington Disease
Transgenic Mice
Phenotype
MicroRNAs
22 Citations (Scopus)

Overexpression of integrin-β1 in leiomyoma promotes cell spreading and proliferation

Chen, H. M., Lin, Y. H., Cheng, Y-M., Wing, L. Y. C. & Tsai, S-J., 2013 May 1, In : Journal of Clinical Endocrinology and Metabolism. 98, 5

Research output: Contribution to journalArticle

Leiomyoma
Integrins
Cell Proliferation
Extracellular Matrix
Cell adhesion
20 Citations (Scopus)

Suppression of annexin A2 by prostaglandin E2 impairs phagocytic ability of peritoneal macrophages in women with endometriosis

Wu, M-H., Chuang, P. C., Lin, Y. J. & Tsai, S-J., 2013 Jan 1, In : Human Reproduction. 28, 4, p. 1045-1053 9 p.

Research output: Contribution to journalArticle

Annexin A2
Peritoneal Macrophages
Endometriosis
Dinoprostone
Macrophages
2 Citations (Scopus)
Transcription factors
Transcription Factors
Genes
Gene expression
Pattern recognition
2012
17 Citations (Scopus)
Hypoxia-Inducible Factor 1
Endometriosis
Stromal Cells
Estrogen Receptors
Estrogens
71 Citations (Scopus)
Phosphorylation
Stromal Cells
MicroRNAs
Gene expression
Gene Expression
17 Citations (Scopus)

Vitamin D receptor 1a promotor -1521 G/C and -1012 A/G polymorphisms in polycystic ovary syndrome

Lin, M. W., Tsai, S-J., Chou, P. Y., Huang, M. F., Sun, H-F. & Wu, M-H., 2012 Dec 1, In : Taiwanese Journal of Obstetrics and Gynecology. 51, 4, p. 565-571 7 p.

Research output: Contribution to journalArticle

Calcitriol Receptors
Polycystic Ovary Syndrome
Metformin
Genotype
Serum
2011
29 Citations (Scopus)

Hypoxia-inhibited dual-specificity phosphatase-2 expression in endometriotic cells regulates cyclooxygenase-2 expression

Wu, M-H., Lin, S-C., Hsiao, K. Y. & Tsai, S-J., 2011 Nov 1, In : Journal of Pathology. 225, 3, p. 390-400 11 p.

Research output: Contribution to journalArticle

Dual Specificity Phosphatase 2
Cyclooxygenase 2
Stromal Cells
Hypoxia-Inducible Factor 1
Extracellular Signal-Regulated MAP Kinases
4 Citations (Scopus)

Inference of transcriptional regulatory network by bootstrapping patterns

Wang, H-C., Chen, Y. HS., Kao, H-Y. & Tsai, S-J., 2011 May 1, In : Bioinformatics. 27, 10, p. 1422-1428 7 p., btr155.

Research output: Contribution to journalArticle

Transcription factors
Gene Regulatory Networks
Regulatory Networks
Bootstrapping
Transcription Factors
20 Citations (Scopus)

Interleukin-6 as an Early Chronic Inflammatory Marker in Polycystic Ovary Syndrome with Insulin Receptor Substrate-2 Polymorphism

Lin, Y. S., Tsai, S-J., Lin, M. W., Yang, C. T., Huang, M. F. & Wu, M-H., 2011 Dec 1, In : American Journal of Reproductive Immunology. 66, 6, p. 527-533 7 p.

Research output: Contribution to journalArticle

Insulin Receptor Substrate Proteins
Polycystic Ovary Syndrome
Interleukin-6
Metformin
Viperidae
58 Citations (Scopus)

Overexpression of pyruvate dehydrogenase kinase 3 increases drug resistance and early recurrence in colon cancer

Lu, C. W., Lin, S-C., Chien, C. W., Lin, S-C., Lee, C-T., Lin, P-W., Lee, J-C. & Tsai, S-J., 2011 Sep 1, In : American Journal of Pathology. 179, 3, p. 1405-1414 10 p.

Research output: Contribution to journalArticle

Drug Resistance
Colonic Neoplasms
Recurrence
Neoplasms
Hypoxia-Inducible Factor 1
51 Citations (Scopus)

Suppression of dual-specificity phosphatase-2 by hypoxia increases chemoresistance and malignancy in human cancer cells

Lin, S-C., Chien, C. W., Lee, J-C., Yeh, Y. C., Hsu, K-F., Lai, Y. Y., Lin, S-C. & Tsai, S-J., 2011 May 2, In : Journal of Clinical Investigation. 121, 5, p. 1905-1916 12 p.

Research output: Contribution to journalArticle

Dual Specificity Phosphatase 2
Hypoxia-Inducible Factor 1
Neoplasms
Dual Specificity Phosphatase 1
Hypoxia
65 Citations (Scopus)

Targeted methylation of two tumor suppressor genes is sufficient to transform mesenchymal stem cells into cancer stem/initiating cells

Teng, I. W., Hou, P. C., Lee, K. D., Chu, P. Y., Yeh, K. T., Jin, V. X., Tseng, M. J., Tsai, S-J., Chang, Y. S., Wu, C. S., Sun, H-F., Tsai, K. D., Jeng, L. B., Nephew, K. P., Huang, T. H. M., Hsiao, S. H. & Leu, Y. W., 2011 Jul 1, In : Cancer Research. 71, 13, p. 4653-4663 11 p.

Research output: Contribution to journalArticle

Neoplastic Stem Cells
Tumor Suppressor Genes
Mesenchymal Stromal Cells
Methylation
Adult Stem Cells
4 Citations (Scopus)

Using unsupervised patterns to extract gene regulation relationships for network construction

Tang, Y. T., Li, S. J., Kao, H-Y., Tsai, S-J. & Wang, H-C., 2011 May 17, In : PloS one. 6, 5, e19633.

Research output: Contribution to journalArticle

Gene expression
Gene Expression
gene expression
extracts
Genes
2010
20 Citations (Scopus)

AUF1 p42 isoform selectively controls both steady-state and PGE2-induced FGF9 mRNA decay

Chen, T. M., Hsu, C. H., Tsai, S-J. & Sun, H-F., 2010 Dec 1, In : Nucleic acids research. 38, 22, p. 8061-8071 11 p.

Research output: Contribution to journalArticle

Fibroblast Growth Factor 9
RNA Stability
Dinoprostone
Protein Isoforms
AU Rich Elements
40 Citations (Scopus)

DNA methylation of the Trip10 promoter accelerates mesenchymal stem cell lineage determination

Hsiao, S. H., Lee, K. D., Hsu, C. C., Tseng, M. J., Jin, V. X., Sun, W. S., Hung, Y. C., Yeh, K. T., Yan, P. S., Lai, Y. Y., Sun, H-F., Lu, Y. J., Chang, Y. S., Tsai, S-J., Huang, T. H. M. & Leu, Y. W., 2010 Sep 1, In : Biochemical and Biophysical Research Communications. 400, 3, p. 305-312 8 p.

Research output: Contribution to journalArticle

Cell Lineage
DNA Methylation
Stem cells
Mesenchymal Stromal Cells
Methylation
27 Citations (Scopus)

Fibroblast growth factor 9 stimulates steroidogenesis in postnatal Leydig cells

Lin, Y., Tsai, C. C., Chung, C. L., Chen, P. R., Sun, H-F., Tsai, S-J. & Huang, B-M., 2010 Jun 1, In : International Journal of Andrology. 33, 3, p. 545-553 9 p.

Research output: Contribution to journalArticle

Fibroblast Growth Factor 9
Leydig Cells
Testosterone
Gonadal Dysgenesis
Disorders of Sex Development
55 Citations (Scopus)

Inhibition of CD36-dependent phagocytosis by prostaglandin E2 contributes to the development of endometriosis

Chuang, P. C., Lin, Y. J., Wu, M-H., Wing, L. Y. C., Shoji, Y. & Tsai, S-J., 2010 Jan 1, In : American Journal of Pathology. 176, 2, p. 850-860 11 p.

Research output: Contribution to journalArticle

Endometriosis
Phagocytosis
Dinoprostone
Peritoneal Macrophages
Macrophages
16 Citations (Scopus)

Leptin on peritoneal macrophages of patients with endometriosis

Wu, M-H., Huang, M. F., Chang, F. M. & Tsai, S-J., 2010 Mar 1, In : American Journal of Reproductive Immunology. 63, 3, p. 214-221 8 p.

Research output: Contribution to journalArticle

Peritoneal Macrophages
Endometriosis
Leptin
Ascitic Fluid
Dinoprost
2009
4 Citations (Scopus)

CDC25 protein expression and interaction with DAZL in human corpus luteum

Pan, H. A., Lee, Y. C., Teng, Y. N., Tsai, S-J., Lin, Y. & Kuo, P-L., 2009 Dec 1, In : Fertility and Sterility. 92, 6, p. 1997-2003 7 p.

Research output: Contribution to journalArticle

Azoospermia
Corpus Luteum
Luteal Cells
Proteins
Luteal Phase