• 3709 Citations
  • 31 h-Index
1989 …2019
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Research Output 1989 2019

  • 3709 Citations
  • 31 h-Index
  • 209 Article
  • 5 Letter
  • 3 Review article
  • 1 Conference article
2012
86 Citations (Scopus)
Phosphatidylinositol 3-Kinase
Berberine
Motor Neurons
Heme Oxygenase-1
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one
24 Citations (Scopus)

Characterizing the effects of Eugenol on neuronal ionic currents and hyperexcitability

Huang, C-W., Chow, J. C., Tsai, J. J. & Wu, S-N., 2012 Jun 1, In : Psychopharmacology. 221, 4, p. 575-587 13 p.

Research output: Contribution to journalArticle

Eugenol
Seizures
Pilocarpine
Action Potentials
Temporal Lobe
3 Citations (Scopus)

Contribution of blocked potassium current conductance and increased conductance of persistent sodium current to the afterdischarge in myelinated neuron

Wu, S-N., Lo, Y. C., Chen, B. S., Cheung So, E. & Chen, L. T., 2012 Aug 1, In : Muscle and Nerve. 46, 2, p. 297-299 3 p.

Research output: Contribution to journalLetter

Organoplatinum Compounds
Biological Models
Potassium Channels
Peripheral Nervous System Diseases
Potassium
5 Citations (Scopus)

Effects of ketamine and its metabolites on ion currents in differentiated hippocampal H19-7 neuronal cells and in HEK293T cells transfected with α-hslo subunit

Huang, M. H., Lin, K. H., Chen, S. J., Shen, A. Y., Wu, F. T. & Wu, S-N., 2012 Oct 1, In : NeuroToxicology. 33, 5, p. 1058-1066 9 p.

Research output: Contribution to journalArticle

Ketamine
Metabolites
Ions
Neurons
Calcium-Activated Potassium Channels
17 Citations (Scopus)

Electrophysiological characterization of sodium-activated potassium channels in NG108-15 and NSC-34 motor neuron-like cells

Wu, S-N., Yeh, C. C., Huang, H. C., So, E. C. & Lo, Y. C., 2012 Oct 1, In : Acta Physiologica. 206, 2, p. 120-134 15 p.

Research output: Contribution to journalArticle

Potassium Channels
Motor Neurons
Sodium
Riluzole
Tetrodotoxin
13 Citations (Scopus)

Evidence for inhibitory effects of flupirtine, a centrally acting analgesic, on delayed rectifier K + currents in motor neuron-like cells

Wu, S. N., Hsu, M. C., Liao, Y. K., Wu, F. T., Jong, Y. J. & Lo, Y. C., 2012 Aug 20, In : Evidence-based Complementary and Alternative Medicine. 2012, 148403.

Research output: Contribution to journalArticle

flupirtine
Motor Neurons
Analgesics
linopirdine
GABA Agents
7 Citations (Scopus)
Inwardly Rectifying Potassium Channel
Mitoxantrone
Osteoclasts
Lipopolysaccharides
Doxorubicin
7 Citations (Scopus)

Investigations into the Correlation Properties of Membrane Electroporation-Induced Inward Currents: Prediction of Pore Formation

Wu, S-N., Yeh, C. C., Wu, P. Y., Huang, H. C. & Tsai, M-L., 2012 Jan 1, In : Cell Biochemistry and Biophysics. 62, 1, p. 211-220 10 p.

Research output: Contribution to journalArticle

Electroporation
Induced currents
Membranes
Chloroquine
Somatotrophs
1 Citation (Scopus)

Possible effects of reduced conductance in delayed-rectifier K+ current on neuronal firing

Wu, S-N., Lo, Y. C., Chen, B. S., Wu, F. T. & So, E. C., 2012 Oct 1, In : Movement Disorders. 27, 12, p. 1581-1582 2 p.

Research output: Contribution to journalLetter

Subthalamic Nucleus
Action Potentials
Parkinson Disease
Neurons
24 Citations (Scopus)
Mitochondrial Dynamics
Cardiac Myocytes
Membrane Potentials
Action Potentials
Ions
10 Citations (Scopus)
Magnetite Nanoparticles
Magnetite nanoparticles
Electroporation
Macrophages
Induced currents
7 Citations (Scopus)

The inhibition by di(2-ethylhexyl)-phthalate of erg-mediated K + current in pituitary tumor (GH 3) cells

Wu, S-N., Yang, W. H., Yeh, C. C. & Huang, H. C., 2012 May 1, In : Archives of Toxicology. 86, 5, p. 713-723 11 p.

Research output: Contribution to journalArticle

Diethylhexyl Phthalate
Pituitary Neoplasms
Tumors
Action Potentials
Esters
2011
19 Citations (Scopus)

Characterization of TRPM8-like channels activated by the cooling agent icilin in the macrophage cell line RAW 264.7

Wu, S-N., Wu, P. Y. & Tsai, M-L., 2011 May 1, In : Journal of Membrane Biology. 241, 1, p. 11-20 10 p.

Research output: Contribution to journalArticle

Macrophages
Cations
icilin
RAW 264.7 Cells
Apamin
7 Citations (Scopus)
Electroporation
Cyclodextrins
Pituitary Neoplasms
Cholesterol
Membranes
2 Citations (Scopus)
Oxidants
Action Potentials
Theoretical Models
Architectural Accessibility
Riluzole
5 Citations (Scopus)

Evidence for aconitine-induced inhibition of delayed rectifier K+ current in Jurkat T-lymphocytes

Wu, S-N., Chen, B. S. & Lo, Y. C., 2011 Oct 28, In : Toxicology. 289, 1, p. 11-18 8 p.

Research output: Contribution to journalArticle

Aconitine
T-cells
T-Lymphocytes
Ions
Jurkat Cells
17 Citations (Scopus)

Evidence for activation of BK Ca channels by a known inhibitor of focal adhesion kinase, PF573228

So, E. C., Wu, K. C., Liang, C. H., Chen, J. Y. & Wu, S. N., 2011 Nov 7, In : Life Sciences. 89, 19-20, p. 691-701 11 p.

Research output: Contribution to journalArticle

Large-Conductance Calcium-Activated Potassium Channels
Focal Adhesion Protein-Tyrosine Kinases
Chemical activation
Membrane Potentials
Cells
6 Citations (Scopus)
KATP Channel
ATP-sensitive Potassium Channel
KATP Channels
Adenosinetriphosphate
potassium channels
15 Citations (Scopus)

Inhibitory action of methadone and its metabolites on erg-mediated K+ current in GH3 pituitary tumor cells

Huang, M. H., Shen, A. Y., Wang, T. S., Wu, H. M., Kang, Y. F., Chen, C. T., Hsu, T. I., Chen, B. S. & Wu, S. N., 2011 Feb 4, In : Toxicology. 280, 1-2, p. 1-9 9 p.

Research output: Contribution to journalArticle

Methadone
Pituitary Neoplasms
Metabolites
Tumors
Cells
11 Citations (Scopus)

Inhibitory effect of memantine, an NMDA-receptor antagonist, on electoporation-induced inward currents in pituitary GH3 cells

Wu, S-N., Huang, H. C., Yeh, C. C., Yang, W. H. & Lo, Y. C., 2011 Feb 18, In : Biochemical and Biophysical Research Communications. 405, 3, p. 508-513 6 p.

Research output: Contribution to journalArticle

Memantine
Glyburide
Induced currents
N-Methyl-D-Aspartate Receptors
Adenosine Triphosphate
8 Citations (Scopus)
Cyclodextrins
Neurons
Neuroendocrine Cells
Bucladesine
Oligosaccharides
2010
15 Citations (Scopus)

Diazoxide reduces status epilepticus neuron damage in diabetes.

Huang, C-W., Wu, S-N., Cheng, J. T., Tsai, J. J. & Huang, C-C., 2010 Jan 1, In : Neurotoxicity research. 17, 4, p. 305-316 12 p.

Research output: Contribution to journalArticle

Diazoxide
Status Epilepticus
Streptozocin
Medical problems
Neurons
2 Citations (Scopus)
Action Potentials
Neurons
Capsaicin
Sensory Receptor Cells
Magnetic Fields
16 Citations (Scopus)

β-Adrenergic modulation of arrhythmogenesis and identification of targeted sites of antiarrhythmic therapy in Timothy (LQT8) syndrome: A theoretical study

Sung, R. J., Wu, Y. H., Lai, N. H. J., Teng, C. H., Luo, C. H., Tien, H. C., Lo, C. P. & Wu, S. N., 2010 Jan 1, In : American Journal of Physiology - Heart and Circulatory Physiology. 298, 1, p. H33-H44

Research output: Contribution to journalArticle

Adrenergic Agents
Theoretical Models
Action Potentials
Calcium-Transporting ATPases
Sarcoplasmic Reticulum
2009
12 Citations (Scopus)

Analytical studies of rapidly inactivating and noninactivating sodium currents in differentiated NG108-15 neuronal cells

Wu, S-N., Chen, B. S., Hsu, T. I., Peng, H., Wu, Y. H. & Lo, Y. C., 2009 Aug 21, In : Journal of Theoretical Biology. 259, 4, p. 828-836 9 p.

Research output: Contribution to journalArticle

Riluzole
action potentials
Sodium
neurons
sodium
39 Citations (Scopus)

Dexmedetomidine, an α2-adrenergic agonist, inhibits neuronal delayed-rectifier potassium current and sodium current

Chen, B. S., Peng, H. & Wu, S-N., 2009 Jan 1, In : British Journal of Anaesthesia. 103, 2, p. 244-254 11 p.

Research output: Contribution to journalArticle

Dexmedetomidine
Adrenergic Agonists
Potassium
Sodium
efaroxan
16 Citations (Scopus)

Diabetic hyperglycemia aggravates seizures and status epilepticus-induced hippocampal damage

Huang, C-W., Cheng, J. T., Tsai, J. J., Wu, S-N. & Huang, C-C., 2009 Feb 24, In : Neurotoxicity research. 15, 1, p. 71-81 11 p.

Research output: Contribution to journalArticle

Status Epilepticus
Streptozocin
Hyperglycemia
Seizures
Rats
17 Citations (Scopus)

Effects of ranolazine, a novel anti-anginal drug, on ion currents and membrane potential in pituitary tumor GH3 cells and NG108-15 neuronal cells

Chen, B. S., Lo, Y. C., Peng, H., Hsu, T. I. & Wu, S-N., 2009 Aug 3, In : Journal of Pharmacological Sciences. 110, 3, p. 295-305 11 p.

Research output: Contribution to journalArticle

Pituitary Neoplasms
Membrane Potentials
Ions
Pharmaceutical Preparations
Calcium-Activated Potassium Channels
13 Citations (Scopus)
etiracetam
Action Potentials
Potassium
Pyrrolidinones
Neurons
26 Citations (Scopus)

The mechanism of the actions of oxaliplatin on ion currents and action potentials in differentiated NG108-15 neuronal cells

Wu, S-N., Chen, B. S., Wu, Y. H., Peng, H. & Chen, L. T., 2009 Jul 1, In : NeuroToxicology. 30, 4, p. 677-685 9 p.

Research output: Contribution to journalArticle

oxaliplatin
Action Potentials
Ions
Riluzole
Bucladesine
10 Citations (Scopus)

Tramadol-induced block of hyperpolarization-activated cation current in rat pituitary lactotrophs

Liu, Y-C., Wang, Y. J., Wu, P. Y. & Wu, S-N., 2009 Feb 1, In : Naunyn-Schmiedeberg's Archives of Pharmacology. 379, 2, p. 127-135 9 p.

Research output: Contribution to journalArticle

Lactotrophs
Tramadol
Cations
Dideoxyadenosine
Propofol
28 Citations (Scopus)
Pyrethrins
Pituitary Neoplasms
Insecticides
Gonadotropin-Releasing Hormone
Neurons
2008
3 Citations (Scopus)

Bronchodilatory effects of S-isopetasin, an antimuscarinic sesquiterpene of Petasites formosanus, on obstructive airway hyperresponsiveness

Lin, L. H., Huang, T. J., Wang, S. H., Lin, Y. L., Wu, S. N. & Ko, W. C., 2008 Apr 28, In : European Journal of Pharmacology. 584, 2-3, p. 398-404 7 p.

Research output: Contribution to journalArticle

Petasites
Muscarinic Antagonists
Sesquiterpenes
Ipratropium
Muscarinic Receptors
21 Citations (Scopus)

Characterization of aconitine-induced block of delayed rectifier K+ current in differentiated NG108-15 neuronal cells

Lin, M. W., Wang, Y. J., Liu, S. I., Lin, A. A., Lo, Y. C. & Wu, S-N., 2008 May 1, In : Neuropharmacology. 54, 6, p. 912-923 12 p.

Research output: Contribution to journalArticle

Aconitine
Action Potentials
Orphenadrine
Neurons
Poisons
13 Citations (Scopus)
Aconitine
aconitine
Action Potential
Depolarization
Potassium
25 Citations (Scopus)

Diabetic hyperglycemia is associated with the severity of epileptic seizures in adults

Huang, C-W., Tsai, J. J., Ou, H-Y., Wang, S-T., Cheng, J. T., Wu, S-N. & Huang, C-C., 2008 Mar 1, In : Epilepsy Research. 79, 1, p. 71-77 7 p.

Research output: Contribution to journalArticle

Hyperglycemia
Epilepsy
Seizures
Recurrence
Cluster Analysis
10 Citations (Scopus)

Evidence for state-dependent block of DPI 201-106, a synthetic inhibitor of NA+ channel inactivation, on delayed-rectifier K+ current in pituitary tumor (GH3) cells

Wang, Y. J., Lin, M. W., Lin, A. A., Peng, H. & Wu, S-N., 2008 Sep, In : Journal of Physiology and Pharmacology. 59, 3, p. 409-423 15 p.

Research output: Contribution to journalArticle

Pituitary Neoplasms
Action Potentials
Ions
Membrane Potentials
Inhibitory Concentration 50
13 Citations (Scopus)

Potent activation of large-conductance Ca2+-activated K + channels by the diphenylurea 1,3-bis-[2-hydroxy-5-(trifluoromethyl) phenyl]urea (NS1643) in pituitary tumor (GH3) cells

Wu, S. N., Peng, H., Chen, B. S., Wang, Y. J., Wu, P. Y. & Lin, M. W., 2008 Dec 1, In : Molecular Pharmacology. 74, 6, p. 1696-1704 9 p.

Research output: Contribution to journalArticle

Calcium-Activated Potassium Channels
Pituitary Neoplasms
Ether
1,3-bis(2-hydroxy-5-trifluoromethylphenyl)urea
N-phenylurea
37 Citations (Scopus)

Riluzole-induced block of voltage-gated Na+ current and activation of BKCa channels in cultured differentiated human skeletal muscle cells

Wang, Y. J., Lin, M. W., Lin, A. A. & Wu, S-N., 2008 Jan 2, In : Life Sciences. 82, 1-2, p. 11-20 10 p.

Research output: Contribution to journalArticle

Riluzole
Muscle Cells
Muscle
Skeletal Muscle
Chemical activation
4 Citations (Scopus)
Pituitary Neoplasms
Tumors
Coloring Agents
Electric potential
Ions
7 Citations (Scopus)

The mechanisms of propofol-induced block on ion currents in differentiated H9c2 cardiac cells

Liu, Y-C., Wang, Y. J. & Wu, S-N., 2008 Aug 20, In : European Journal of Pharmacology. 590, 1-3, p. 93-98 6 p.

Research output: Contribution to journalArticle

Propofol
Ions
Anesthetics
Pinacidil
Intravenous Anesthetics
32 Citations (Scopus)
Potassium
Sodium
Neurons
Action Potentials
oxcarbazepine
14 Citations (Scopus)

Time-dependent block of ultrarapid-delayed rectifier K+ currents by aconitine, a potent cardiotoxin, in heart-derived H9c2 myoblasts and in neonatal rat ventricular myocytes

Wang, Y. J., Chen, B. S., Lin, M. W., Lin, A. A., Peng, H., Sung, R. J. & Wu, S-N., 2008 Nov 28, In : Toxicological Sciences. 106, 2, p. 454-463 10 p.

Research output: Contribution to journalArticle

Cardiotoxins
Aconitine
Myoblasts
Muscle Cells
Rats
2007
22 Citations (Scopus)
zonisamide
Large-Conductance Calcium-Activated Potassium Channels
Anticonvulsants
Neurons
Ions
27 Citations (Scopus)

Glucose and hippocampal neuronal excitability: Role of ATP-sensitive potassium channels

Huang, C-W., Huang, C-C., Cheng, J. T., Tsai, J. J. & Wu, S-N., 2007 May 15, In : Journal of Neuroscience Research. 85, 7, p. 1468-1477 10 p.

Research output: Contribution to journalArticle

KATP Channels
Glucose
Adenosine Triphosphate
Action Potentials
Diazoxide
15 Citations (Scopus)

Identification of two types of ATP-sensitive K+ channels in rat ventricular myocytes

Wu, S-N., Wu, A. Z. & Sung, R. J., 2007 Jan 2, In : Life Sciences. 80, 4, p. 378-387 10 p.

Research output: Contribution to journalArticle

KATP Channels
Muscle Cells
Rats
Adenosine Triphosphate
Dinitrophenols
9 Citations (Scopus)

Inhibition of intermediate-conductance Ca2+-activated K + channel and cytoprotective properties of 4-piperidinomethyl-2- isopropyl-5-methylphenol

Shen, A. Y., Tsai, J. H., Teng, H. C., Huang, M. H. & Wu, S. N., 2007 May 1, In : Journal of Pharmacy and Pharmacology. 59, 5, p. 679-685 7 p.

Research output: Contribution to journalArticle

Calcium-Activated Potassium Channels
Erythrocytes
Clotrimazole
Thymol
HL-60 Cells
25 Citations (Scopus)
Calcium-Activated Potassium Channels
Pituitary Neoplasms
Protein Kinase C
Tumors
Chemical activation

Reliability analysis of physiological phenomena by cardiac action potential model

Luo, C. H., Chen, P. Y., Teng, C. H., Wu, S. N. & Sung, R. J., 2007 Sep 27, In : Proceedings - IEEE International Symposium on Circuits and Systems. p. 2890-2893 4 p., 4253282.

Research output: Contribution to journalConference article

Reliability analysis
Physiology
14 Citations (Scopus)

The activation by estrogen receptor agonists of the BKCa-channel in human cardiac fibroblasts

Wang, Y. J., Lin, M. W., Wu, S-N. & Sung, R. J., 2007 May 1, In : Biochemical Pharmacology. 73, 9, p. 1347-1357 11 p.

Research output: Contribution to journalArticle

Fibroblasts
Estrogens
Chemical activation
Estrogen Receptors
Calcium-Activated Potassium Channels