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Sheng-Nan Wu

Professor

  • 3636 Citations
  • 30 h-Index
1989 …2019
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Research Output 1989 2019

  • 3636 Citations
  • 30 h-Index
  • 206 Article
  • 5 Letter
  • 3 Review article
  • 1 Conference article
2006
15 Citations (Scopus)

Diethyl pyrocarbonate, a histidine-modifying agent, directly stimulates activity of ATP-sensitive potassium channels in pituitary GH3 cells

Wu, S-N. & Chang, H. D., 2006 Feb 28, In : Biochemical Pharmacology. 71, 5, p. 615-623 9 p.

Research output: Contribution to journal › Article

Diethyl Pyrocarbonate
KATP Channels
Histidine
Action Potentials
Glyburide
18 Citations (Scopus)

Diosgenin, a plant-derived sapogenin, stimulates Ca2+-activated K+ current in human cortical HCN-1A neuronal cells

Wang, Y. J., Liu, Y-C., Chang, H. D. & Wu, S-N., 2006 Apr 1, In : Planta Medica. 72, 5, p. 430-436 7 p.

Research output: Contribution to journal › Article

Diosgenin
Sapogenins
Large-Conductance Calcium-Activated Potassium Channels
Neurons
Apamin
33 Citations (Scopus)

Electrophysiological mechanisms of ventricular arrhythmias in relation to Andersen-Tawil syndrome under conditions of reduced I K1: A simulation study

Sung, R. J., Wu, S-N., Wu, J. S., Chang, H. D. & Luo, C. H., 2006 Dec 18, In : American Journal of Physiology - Heart and Circulatory Physiology. 291, 6

Research output: Contribution to journal › Article

Andersen Syndrome
Cardiac Arrhythmias
Inwardly Rectifying Potassium Channel
Adrenergic Agents
Membrane Potentials
19 Citations (Scopus)

Glucocorticoids stimulate the activity of large-conductance Ca 2+-activated K+ channels in pituitary GH3 and AtT-20 cells via a non-genomic mechanism

Huang, M. H., So, E. C., Liu, Y-C. & Wu, S-N., 2006 Feb 1, In : Steroids. 71, 2, p. 129-140 12 p.

Research output: Contribution to journal › Article

Dexamethasone
Glucocorticoids
Mifepristone
Glyburide
Glucocorticoid Receptors
23 Citations (Scopus)

Pharmacological roles of the large-conductance calcium-activated potassium channel

Wu, S-N., Wu, A. Z. & Lin, M. W., 2006 May, In : Current Topics in Medicinal Chemistry. 6, 10, p. 1025-1030 6 p.

Research output: Contribution to journal › Review article

Large-Conductance Calcium-Activated Potassium Channels
Pharmacology
Muscle
Acetogenins
Cells
23 Citations (Scopus)

The opening effect of pregabalin on ATP-sensitive potassium channels in differentiated hippocampal neuron-derived H19-7 cells

Huang, C-W., Huang, C-C. & Wu, S-N., 2006 Apr 1, In : Epilepsia. 47, 4, p. 720-726 7 p.

Research output: Contribution to journal › Article

KATP Channels
Potassium Channels
Adenosine Triphosphate
Neurons
2,4-Dinitrophenol
23 Citations (Scopus)

Tramadol-induced blockade of delayed rectifier potassium current in NG108-15 neuronal cells

Tsai, T. Y., Tsai, Y-C., Wu, S-N. & Liu, Y-C., 2006 Oct 1, In : European Journal of Pain. 10, 7, p. 597-601 5 p.

Research output: Contribution to journal › Article

Tramadol
Potassium
Membrane Potentials
Action Potentials
Inhibitory Concentration 50
2005
8 Citations (Scopus)

BAY 41-2272, a potent activator of soluble guanylyl cyclase, stimulates calcium elevation and calcium-activated potassium current in pituitary GH 3 cells

Liu, Y-C. & Wu, S-N., 2005 Dec 1, In : Clinical and Experimental Pharmacology and Physiology. 32, 12, p. 1078-1087 10 p.

Research output: Contribution to journal › Article

Somatotrophs
Potassium
Calcium
Soluble Guanylyl Cyclase
3-(4-Amino-5-cyclopropylpyrimidine-2-yl)-1-(2-fluorobenzyl)-1H-pyrazolo(3,4-b)pyridine
7 Citations (Scopus)

Characterization of chromanol 293B-induced block of the delayed-rectifier K+ current in heart-derived H9c2 cells

Lo, Y. C., Yang, S. R., Huang, M. H., Liu, Y-C. & Wu, S-N., 2005 Apr 1, In : Life Sciences. 76, 20, p. 2275-2286 12 p.

Research output: Contribution to journal › Article

Apamin
Quinidine
Myoblasts
6-cyano-4-(N-ethylsulfonyl-N-methylamino)-3-hydroxy-2,2-dimethylchromane
Inhibitory Concentration 50
29 Citations (Scopus)

Inhibitory action of L-type Ca2+ current by paeoniflorin, a major constituent of peony root, in NG108-15 neuronal cells

Tsai, T. Y., Wu, S-N., Liu, Y-C., Wu, A. Z. & Tsai, Y-C., 2005 Oct 31, In : European Journal of Pharmacology. 523, 1-3, p. 16-24 9 p.

Research output: Contribution to journal › Article

Paeonia
Action Potentials
peoniflorin
Ions
Purinergic P1 Receptors
11 Citations (Scopus)

Properties of BKCa channels in oral keratinocytes

Shieh, D-B., Yang, S. R., Shi, X. Y., Wu, Y. N. & Wu, S-N., 2005 May 1, In : Journal of Dental Research. 84, 5, p. 468-473 6 p.

Research output: Contribution to journal › Article

Keratinocytes
Propolis
Apamin
Patch-Clamp Techniques
Ion Channels

Sodium cyanate-induced opening of calcium-activated potassium currents in hippocampal neuron-derived H19-7 cells

Huang, C-W., Huang, C-C., Huang, M. H., Wu, S-N. & Hsieh, Y. J., 2005 Mar 29, In : Neuroscience Letters. 377, 2, p. 110-114 5 p.

Research output: Contribution to journal › Article

Potassium
Calcium
Neurons
Large-Conductance Calcium-Activated Potassium Channels
Poisons
12 Citations (Scopus)

Stimulatory actions of thymol, a natural product, on Ca2+- activated K+ current in pituitary GH3 cells

Huang, M. H., Wu, S-N. & Shen, A. Y., 2005 Dec 1, In : Planta Medica. 71, 12, p. 1093-1098 6 p.

Research output: Contribution to journal › Article

Thymol
Biological Products
Large-Conductance Calcium-Activated Potassium Channels
Menthol
Calcium-Activated Potassium Channels
10 Citations (Scopus)

Stretch-stimulated activity of large conductance calcium-activated potassium channels in human retinal pigment epithelial cells

Sheu, S. J., Wu, S-N. & Hu, D. N., 2005 Dec 1, In : Journal of Ocular Pharmacology and Therapeutics. 21, 6, p. 429-435 7 p.

Research output: Contribution to journal › Article

Large-Conductance Calcium-Activated Potassium Channels
Retinal Pigments
Epithelial Cells
Membranes
Riluzole
2004
21 Citations (Scopus)

Cilostazol, an Inhibitor of Type 3 Phosphodiesterase, Stimulates Large-Conductance, Calcium-Activated Potassium Channels in Pituitary GH 3 Cells and Pheochromocytoma PC12 Cells

Wu, S-N., Liu, S. I. & Huang, M. H., 2004 Mar 1, In : Endocrinology. 145, 3, p. 1175-1184 10 p.

Research output: Contribution to journal › Article

Phosphodiesterase 3 Inhibitors
Somatotrophs
Large-Conductance Calcium-Activated Potassium Channels
PC12 Cells
Pheochromocytoma
25 Citations (Scopus)

Inhibitory effect of lamotrigine on A-type potassium current in hippocampal neuron-derived H19-7 cells

Huang, C-W., Huang, C-C., Liu, Y-C. & Wu, S-N., 2004 Jul 1, In : Epilepsia. 45, 7, p. 729-736 8 p.

Research output: Contribution to journal › Article

Potassium
Neurons
4-Aminopyridine
lamotrigine
Tetraethylammonium
10 Citations (Scopus)

Simulations of the cardiac action potential based on the Hodgkin-Huxley kinetics with the use of Microsoft Excel spreadsheets

Wu, S-N., 2004 Mar 31, In : Chinese Journal of Physiology. 47, 1, p. 15-22 8 p.

Research output: Contribution to journal › Article

Action Potentials
Ion Channels
Membrane Potentials
Theoretical Models
Language
30 Citations (Scopus)

Stimulatory actions of caffeic acid phenethyl ester, a known inhibitor of NF-κB activation, on Ca2+-activated K+ current in pituitary GH3 cells

Lin, M. W., Yang, S. R., Huang, M. H. & Wu, S-N., 2004 Jun 25, In : Journal of Biological Chemistry. 279, 26, p. 26885-26892 8 p.

Research output: Contribution to journal › Article

Chemical activation
Membrane Potentials
Propolis
Membranes
tert-Butylhydroperoxide
6 Citations (Scopus)

The influence of hypotonicity on large-conductance calcium-activated potassium channels in human retinal pigment epithelial cells

Sheu, S. J., Wu, S-N., Hu, D. N. & Chen, J. F., 2004 Dec 1, In : Journal of Ocular Pharmacology and Therapeutics. 20, 6, p. 563-575 13 p.

Research output: Contribution to journal › Article

Large-Conductance Calcium-Activated Potassium Channels
Retinal Pigments
Epithelial Cells
Hypotonic Solutions
tetrandrine
2003
18 Citations (Scopus)

An Outbreak of Food-borne Illness Due to Methomyl Contamination

Tsai, M. J., Wu, S-N., Cheng, H. A., Wang, S. H. & Chiang, H. T., 2003 Dec 1, In : Journal of Toxicology - Clinical Toxicology. 41, 7, p. 969-973 5 p.

Research output: Contribution to journal › Article

Methomyl
Foodborne Diseases
Disease Outbreaks
Dizziness
Contamination
25 Citations (Scopus)

Behavior of nonselective cation channels and large-conductance Ca2+-activated K+ channels induced by dynamic changes in membrane stretch in cultured smooth muscle cells of human coronary artery

Wu, S-N., Lin, P. H., Hsieh, K. S., Liu, Y-C. & Chiang, H. T., 2003 Jan 1, In : Journal of Cardiovascular Electrophysiology. 14, 1, p. 44-51 8 p.

Research output: Contribution to journal › Article

Calcium-Activated Potassium Channels
Smooth Muscle Myocytes
Cations
Coronary Vessels
Membranes
26 Citations (Scopus)

Biological Study of Naphthalene Derivatives with Antiinflammatory Activities

Huang, M. H., Wu, S-N., Wang, J. P., Lin, C. H., Lu, S. I., Liao, L. F. & Shen, A. Y., 2003 Dec 1, In : Drug Development Research. 60, 4, p. 261-269 9 p.

Research output: Contribution to journal › Article

methionyl-leucyl-phenylalanine
Muramidase
Acetates
Neutrophils
Anti-Inflammatory Agents
20 Citations (Scopus)

Block of erg current by linoleoylamide, a sleep-inducing agent, in pituitary GH3 cells

Liu, Y-C. & Wu, S-N., 2003 Jan 1, In : European Journal of Pharmacology. 458, 1-2, p. 37-47 11 p.

Research output: Contribution to journal › Article

Sleep
Arachidonic Acid
Calcium-Activated Potassium Channels
linoleoylamide
Neuroblastoma
25 Citations (Scopus)

Differential effects of quercetin, a natural polyphenolic flavonoid, on L-type calcium current in pituitary tumor (GH3) cells and neuronal NG108-15 cells

Wu, S-N., Chiang, H. T., Shen, A. Y. & Lo, Y. K., 2003 May 1, In : Journal of Cellular Physiology. 195, 2, p. 298-308 11 p.

Research output: Contribution to journal › Article

Quercetin
Pituitary Neoplasms
Flavonoids
Tumors
Calcium
14 Citations (Scopus)

Effect of arvanil (N-arachidonoyl-vanillyl-amine), a nonpungent anandamide-capsaicin hybrid, on ion currents in NG108-15 neuronal cells

Lo, Y. K., Chiang, H. T. & Wu, S-N., 2003 Feb 15, In : Biochemical Pharmacology. 65, 4, p. 581-591 11 p.

Research output: Contribution to journal › Article

Capsaicin
Amines
Ions
Ether
Clamping devices
19 Citations (Scopus)

Inhibitory action of ICI-182,780, an estrogen receptor antagonist, on BKCa channel activity in cultured endothelial cells of human coronary artery

Liu, Y-C., Lo, Y. C., Huang, C-W. & Wu, S-N., 2003 Nov 15, In : Biochemical Pharmacology. 66, 10, p. 2053-2063 11 p.

Research output: Contribution to journal › Article

Endothelial cells
Cultured Cells
Coronary Vessels
Endothelial Cells
Masoprocol
96 Citations (Scopus)

Large-conductance Ca2+-activated K+ channels: Physiological role and pharmacology

Wu, S-N., 2003 Apr 1, In : Current Medicinal Chemistry. 10, 8, p. 649-661 13 p.

Research output: Contribution to journal › Review article

Calcium-Activated Potassium Channels
Endothelial cells
Neuroendocrine Cells
Endothelial Cells
vinpocetine
6 Citations (Scopus)

Mechanism of carvedilol-induced block of delayed rectifier K+ current in the NG108-15 neuronal cell line

Liu, C. P., Chiang, H. T., Jan, C. R. & Wu, S-N., 2003 Feb 1, In : Drug Development Research. 58, 2, p. 196-208 13 p.

Research output: Contribution to journal › Article

Cell Line
tert-Butylhydroperoxide
Carbonyl Cyanide m-Chlorophenyl Hydrazone
carvedilol
Diazoxide
24 Citations (Scopus)

Mechanism of inhibitory actions of oxidizing agents on calcium-activated potassium current in cultured pigment epithelial cells of the human retina

Sheu, S. J. & Wu, S-N., 2003 Mar 1, In : Investigative Ophthalmology and Visual Science. 44, 3, p. 1237-1244 8 p.

Research output: Contribution to journal › Article

Oxidants
Retina
Potassium
Epithelial Cells
Thimerosal
23 Citations (Scopus)

Stimulatory effects of chlorzoxazone, a centrally acting muscle relaxant, on large conductance calcium-activated potassium channels in pituitary GH3 cells

Liu, Y-C., Lo, Y. K. & Wu, S-N., 2003 Jan 3, In : Brain Research. 959, 1, p. 86-97 12 p.

Research output: Contribution to journal › Article

Central Muscle Relaxants
Chlorzoxazone
Large-Conductance Calcium-Activated Potassium Channels
Neuroendocrine Cells
Chlormezanone
18 Citations (Scopus)

Stimulatory effects of squamocin, an Annonaceous acetogenin, on Ca2+-activated K+ current in cultured smooth muscle cells of human coronary artery

Wu, S-N., Chiang, H. T., Chang, F. R., Liaw, C. C. & Wu, Y. C., 2003 Jan 1, In : Chemical Research in Toxicology. 16, 1, p. 15-22 8 p.

Research output: Contribution to journal › Article

Acetogenins
Smooth Muscle Myocytes
Muscle
Coronary Vessels
Cells
15 Citations (Scopus)

The mechanism of inhibitory actions of S-petasin, a sesquiterpene of Petasites formosanus, on L-type calcium current in NG108-15 neuronal cells

Wu, S-N., Chen, H. & Lin, Y. L., 2003 Feb 1, In : Planta Medica. 69, 2, p. 118-124 7 p.

Research output: Contribution to journal › Article

Petasites
Sesquiterpenes
Calcium
Electric potential
petasin
2002
29 Citations (Scopus)

Block of L-Type Ca2+ current by beauvericin, a toxic cyclopeptide, in the NG108-15 neuronal cell line

Wu, S-N., Chen, H., Liu, Y-C. & Chiang, H. T., 2002 Jul 2, In : Chemical Research in Toxicology. 15, 6, p. 854-860 7 p.

Research output: Contribution to journal › Article

Cyclic Peptides
Poisons
Cells
Cell Line
Clamping devices
10 Citations (Scopus)

Enhanced activity of Ca2+-activated K+ channels by 1-[2-hydroxy-3-propyl-4-[(1H-tetrazol-5-yl) butoxyl]phenyl] ethanone (LY-171883) in neuroendocrine and neuroblastoma cell lines

Li, P. C., Liang, J. T., Huang, H. T., Lin, P. H. & Wu, S-N., 2002 Jul 20, In : Journal of Cellular Physiology. 192, 2, p. 188-199 12 p.

Research output: Contribution to journal › Article

LY 171883
Calcium-Activated Potassium Channels
Neuroendocrine Cells
Neuroblastoma
Cells
17 Citations (Scopus)

Inhibition of Ca2+-activated and voltage-dependent K+ currents by 2-mercaptophenyl-1,4-naphthoquinone in pituitary GH3 cells: Contribution to its antiproliferative effect

Huang, M. H., Wu, S-N., Chen, C. P. & Shen, A. Y., 2002 Jan 25, In : Life Sciences. 70, 10, p. 1185-1203 19 p.

Research output: Contribution to journal › Article

Electric potential
Vitamin K 3
Cell Proliferation
Cell proliferation
Inhibitory Concentration 50
24 Citations (Scopus)

Inhibitory effect of the plant-extract osthole on L-type calcium current in NG108-15 neuronal cells

Wu, S-N., Lo, Y. K., Chen, C. C., Li, H. F. & Chiang, H. T., 2002 Jan 15, In : Biochemical Pharmacology. 63, 2, p. 199-206 8 p.

Research output: Contribution to journal › Article

Plant Extracts
Calcium
Cyclic GMP
Clamping devices
Electric potential
38 Citations (Scopus)

Stimulation of the BKCa channel in cultured smooth muscle cells of human trachea by magnolol

Wu, S-N., Chen, C. C., Li, H. F., Lo, Y. K., Chen, S. A. & Chiang, H. T., 2002 Jan 30, In : Thorax. 57, 1, p. 67-74 8 p.

Research output: Contribution to journal › Article

Trachea
Smooth Muscle Myocytes
Anti-Asthmatic Agents
Patch-Clamp Techniques
magnolol
2001
28 Citations (Scopus)

Ceramide inhibits the inwardly rectifying potassium current in GH3 lactotrophs

Wu, S-N., Lo, Y. K., Kuo, B. I. T. & Chiang, H. T., 2001 Jan 1, In : Endocrinology. 142, 11, p. 4785-4794 10 p.

Research output: Contribution to journal › Article

Lactotrophs
Ceramides
Potassium
Calcium-Activated Potassium Channels
Dithiothreitol
15 Citations (Scopus)

Characterization of action potential waveform-evoked L-type calcium currents in pituitary GH3 cells

Lo, Y. K., Wu, S-N., Lee, C. T., Li, H. F. & Chiang, H. T., 2001 Aug 2, In : Pflugers Archiv European Journal of Physiology. 442, 4, p. 547-557 11 p.

Research output: Contribution to journal › Article

Action Potentials
Calcium
Bioelectric potentials
Clamping devices
Electric potential
25 Citations (Scopus)

Fenamates stimulate BKCa channel activity in the human osteoblast-like MG-63 cells

Wu, S-N., Jan, C. R. & Chiang, H. T., 2001 Jan 1, In : Journal of Investigative Medicine. 49, 6, p. 522-533 12 p.

Research output: Contribution to journal › Article

Fenamates
Niflumic Acid
Osteoblasts
Human Activities
Meclofenamic Acid
15 Citations (Scopus)

Functional coupling of voltage-dependent L-type Ca 2+ current to Ca 2+ -activated K + current in pituitary GH 3 cells

Wu, S-N., Lo, Y. K., Li, H. F. & Shen, A. Y., 2001 Jan 1, In : Chinese Journal of Physiology. 44, 4, p. 161-167 7 p.

Research output: Contribution to journal › Article

Somatotrophs
tetrandrine
3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester
Apamin
Nimodipine
24 Citations (Scopus)

Inhibition of large-conductance calcium-activated potassium channel by 2-methoxyestradiol in cultured vascular endothelial (HUV-EC-C) cells

Chiang, H. T. & Wu, S-N., 2001 Aug 1, In : Journal of Membrane Biology. 182, 3, p. 203-212 10 p.

Research output: Contribution to journal › Article

Large-Conductance Calcium-Activated Potassium Channels
Blood Vessels
Evans Blue
Endothelial Cells
2-methoxyestradiol
1 Citation (Scopus)

On the mechanism of selective action of probucol on the inwardly rectifying potassium current in GH3 lactotrophs

Chiang, H. T. & Wu, S-N., 2001 Jan 1, In : Drug Development Research. 54, 1, p. 1-11 11 p.

Research output: Contribution to journal › Article

Lactotrophs
Probucol
Potassium
Bepridil
Thimerosal
9 Citations (Scopus)

Quantitative analysis of end-tidal carbon dioxide during mechanical and spontaneous ventilation in infants and young children

Hsieh, K. S., Lee, C. L., Lin, C. C., Wu, S-N., Ko, F. Y., Huang, Y. F. & Huang, T. C., 2001 Dec 18, In : Pediatric Pulmonology. 32, 6, p. 453-458 6 p.

Research output: Contribution to journal › Article

Mechanical Ventilators
Artificial Respiration
Carbon Dioxide
Capnography
Pediatrics
34 Citations (Scopus)

Rutaecarpine-induced block of delayed rectifier K + current in NG108-15 neuronal cells

Wu, S-N., Lo, Y., Chen, H., Li, H. F. & Chiang, H. T., 2001 Nov 7, In : Neuropharmacology. 41, 7, p. 834-843 10 p.

Research output: Contribution to journal › Article

Action Potentials
rutecarpine
Quinidine
E 4031
dendrotoxin
22 Citations (Scopus)

Vinpocetine-induced stimulation of calcium-activated potassium currents in rat pituitary GH3 cells

Wu, S-N., Li, H. F. & Chiang, H. T., 2001 Apr 1, In : Biochemical Pharmacology. 61, 7, p. 877-892 16 p.

Research output: Contribution to journal › Article

vinpocetine
Rats
Potassium
Calcium
Clamping devices
2000
28 Citations (Scopus)

Actions of epoxyeicosatrienoic acid on large-conductance Ca2+-activated K+ channels in pituitary GH3 cells

Wu, S-N., Li, H. F. & Chiang, H. T., 2000 Jul 15, In : Biochemical Pharmacology. 60, 2, p. 251-262 12 p.

Research output: Contribution to journal › Article

Calcium-Activated Potassium Channels
Large-Conductance Calcium-Activated Potassium Channels
Acids
14,15-epoxy-5,8,11-eicosatrienoic acid
Neuroendocrine Cells
24 Citations (Scopus)

Characterization of ATP-sensitive potassium channels functionally expressed in pituitary GH3 cells

Wu, S-N., Li, H. F. & Chiang, H. T., 2000 Dec 1, In : Journal of Membrane Biology. 178, 3, p. 205-214 10 p.

Research output: Contribution to journal › Article

KATP Channels
Adenosine Triphosphate
Melitten
Diazoxide
Membrane Potentials
30 Citations (Scopus)

Characterization of inhibition by risperidone of the inwardly rectifying K+ current in pituitary GH3 cells

Wu, S-N., Jan, C. R., Li, H. F. & Chiang, H. T., 2000 Nov 1, In : Neuropsychopharmacology. 23, 6, p. 676-689 14 p.

Research output: Contribution to journal › Article

Risperidone
Large-Conductance Calcium-Activated Potassium Channels
Thioridazine
Metoclopramide
Clozapine
26 Citations (Scopus)

Characterization of tetrandrine-induced inhibition of large-conductance calcium-activated potassium channels in a human endothelial cell line (HUV- EC-C)

Wu, S-N., Li, H. F. & Lo, Y. C., 2000 Jan, In : Journal of Pharmacology and Experimental Therapeutics. 292, 1, p. 188-195 8 p.

Research output: Contribution to journal › Article

tetrandrine
Large-Conductance Calcium-Activated Potassium Channels
Endothelial Cells
Cell Line
Niflumic Acid