• 3636 Citations
  • 30 h-Index
1989 …2019
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Research Output 1989 2019

  • 3636 Citations
  • 30 h-Index
  • 206 Article
  • 5 Letter
  • 3 Review article
  • 1 Conference article
2006
15 Citations (Scopus)
Diethyl Pyrocarbonate
KATP Channels
Histidine
Action Potentials
Glyburide
18 Citations (Scopus)

Diosgenin, a plant-derived sapogenin, stimulates Ca2+-activated K+ current in human cortical HCN-1A neuronal cells

Wang, Y. J., Liu, Y-C., Chang, H. D. & Wu, S-N., 2006 Apr 1, In : Planta Medica. 72, 5, p. 430-436 7 p.

Research output: Contribution to journalArticle

Diosgenin
Sapogenins
Large-Conductance Calcium-Activated Potassium Channels
Neurons
Apamin
33 Citations (Scopus)
Andersen Syndrome
Cardiac Arrhythmias
Inwardly Rectifying Potassium Channel
Adrenergic Agents
Membrane Potentials
19 Citations (Scopus)

Glucocorticoids stimulate the activity of large-conductance Ca 2+-activated K+ channels in pituitary GH3 and AtT-20 cells via a non-genomic mechanism

Huang, M. H., So, E. C., Liu, Y-C. & Wu, S-N., 2006 Feb 1, In : Steroids. 71, 2, p. 129-140 12 p.

Research output: Contribution to journalArticle

Dexamethasone
Glucocorticoids
Mifepristone
Glyburide
Glucocorticoid Receptors
23 Citations (Scopus)

Pharmacological roles of the large-conductance calcium-activated potassium channel

Wu, S-N., Wu, A. Z. & Lin, M. W., 2006 May, In : Current Topics in Medicinal Chemistry. 6, 10, p. 1025-1030 6 p.

Research output: Contribution to journalReview article

Large-Conductance Calcium-Activated Potassium Channels
Pharmacology
Muscle
Acetogenins
Cells
23 Citations (Scopus)
KATP Channels
Potassium Channels
Adenosine Triphosphate
Neurons
2,4-Dinitrophenol
23 Citations (Scopus)

Tramadol-induced blockade of delayed rectifier potassium current in NG108-15 neuronal cells

Tsai, T. Y., Tsai, Y-C., Wu, S-N. & Liu, Y-C., 2006 Oct 1, In : European Journal of Pain. 10, 7, p. 597-601 5 p.

Research output: Contribution to journalArticle

Tramadol
Potassium
Membrane Potentials
Action Potentials
Inhibitory Concentration 50
2005
8 Citations (Scopus)
Somatotrophs
Potassium
Calcium
Soluble Guanylyl Cyclase
3-(4-Amino-5-cyclopropylpyrimidine-2-yl)-1-(2-fluorobenzyl)-1H-pyrazolo(3,4-b)pyridine
7 Citations (Scopus)

Characterization of chromanol 293B-induced block of the delayed-rectifier K+ current in heart-derived H9c2 cells

Lo, Y. C., Yang, S. R., Huang, M. H., Liu, Y-C. & Wu, S-N., 2005 Apr 1, In : Life Sciences. 76, 20, p. 2275-2286 12 p.

Research output: Contribution to journalArticle

Apamin
Quinidine
Myoblasts
6-cyano-4-(N-ethylsulfonyl-N-methylamino)-3-hydroxy-2,2-dimethylchromane
Inhibitory Concentration 50
29 Citations (Scopus)

Inhibitory action of L-type Ca2+ current by paeoniflorin, a major constituent of peony root, in NG108-15 neuronal cells

Tsai, T. Y., Wu, S-N., Liu, Y-C., Wu, A. Z. & Tsai, Y-C., 2005 Oct 31, In : European Journal of Pharmacology. 523, 1-3, p. 16-24 9 p.

Research output: Contribution to journalArticle

Paeonia
Action Potentials
peoniflorin
Ions
Purinergic P1 Receptors
11 Citations (Scopus)

Properties of BKCa channels in oral keratinocytes

Shieh, D-B., Yang, S. R., Shi, X. Y., Wu, Y. N. & Wu, S-N., 2005 May 1, In : Journal of Dental Research. 84, 5, p. 468-473 6 p.

Research output: Contribution to journalArticle

Keratinocytes
Propolis
Apamin
Patch-Clamp Techniques
Ion Channels

Sodium cyanate-induced opening of calcium-activated potassium currents in hippocampal neuron-derived H19-7 cells

Huang, C-W., Huang, C-C., Huang, M. H., Wu, S-N. & Hsieh, Y. J., 2005 Mar 29, In : Neuroscience Letters. 377, 2, p. 110-114 5 p.

Research output: Contribution to journalArticle

Potassium
Calcium
Neurons
Large-Conductance Calcium-Activated Potassium Channels
Poisons
12 Citations (Scopus)

Stimulatory actions of thymol, a natural product, on Ca2+- activated K+ current in pituitary GH3 cells

Huang, M. H., Wu, S-N. & Shen, A. Y., 2005 Dec 1, In : Planta Medica. 71, 12, p. 1093-1098 6 p.

Research output: Contribution to journalArticle

Thymol
Biological Products
Large-Conductance Calcium-Activated Potassium Channels
Menthol
Calcium-Activated Potassium Channels
10 Citations (Scopus)
Large-Conductance Calcium-Activated Potassium Channels
Retinal Pigments
Epithelial Cells
Membranes
Riluzole
2004
21 Citations (Scopus)
Phosphodiesterase 3 Inhibitors
Somatotrophs
Large-Conductance Calcium-Activated Potassium Channels
PC12 Cells
Pheochromocytoma
25 Citations (Scopus)

Inhibitory effect of lamotrigine on A-type potassium current in hippocampal neuron-derived H19-7 cells

Huang, C-W., Huang, C-C., Liu, Y-C. & Wu, S-N., 2004 Jul 1, In : Epilepsia. 45, 7, p. 729-736 8 p.

Research output: Contribution to journalArticle

Potassium
Neurons
4-Aminopyridine
lamotrigine
Tetraethylammonium
10 Citations (Scopus)
Action Potentials
Ion Channels
Membrane Potentials
Theoretical Models
Language
30 Citations (Scopus)

Stimulatory actions of caffeic acid phenethyl ester, a known inhibitor of NF-κB activation, on Ca2+-activated K+ current in pituitary GH3 cells

Lin, M. W., Yang, S. R., Huang, M. H. & Wu, S-N., 2004 Jun 25, In : Journal of Biological Chemistry. 279, 26, p. 26885-26892 8 p.

Research output: Contribution to journalArticle

Chemical activation
Membrane Potentials
Propolis
Membranes
tert-Butylhydroperoxide
6 Citations (Scopus)

The influence of hypotonicity on large-conductance calcium-activated potassium channels in human retinal pigment epithelial cells

Sheu, S. J., Wu, S-N., Hu, D. N. & Chen, J. F., 2004 Dec 1, In : Journal of Ocular Pharmacology and Therapeutics. 20, 6, p. 563-575 13 p.

Research output: Contribution to journalArticle

Large-Conductance Calcium-Activated Potassium Channels
Retinal Pigments
Epithelial Cells
Hypotonic Solutions
tetrandrine
2003
18 Citations (Scopus)

An Outbreak of Food-borne Illness Due to Methomyl Contamination

Tsai, M. J., Wu, S-N., Cheng, H. A., Wang, S. H. & Chiang, H. T., 2003 Dec 1, In : Journal of Toxicology - Clinical Toxicology. 41, 7, p. 969-973 5 p.

Research output: Contribution to journalArticle

Methomyl
Foodborne Diseases
Disease Outbreaks
Dizziness
Contamination
25 Citations (Scopus)
Calcium-Activated Potassium Channels
Smooth Muscle Myocytes
Cations
Coronary Vessels
Membranes
26 Citations (Scopus)

Biological Study of Naphthalene Derivatives with Antiinflammatory Activities

Huang, M. H., Wu, S-N., Wang, J. P., Lin, C. H., Lu, S. I., Liao, L. F. & Shen, A. Y., 2003 Dec 1, In : Drug Development Research. 60, 4, p. 261-269 9 p.

Research output: Contribution to journalArticle

methionyl-leucyl-phenylalanine
Muramidase
Acetates
Neutrophils
Anti-Inflammatory Agents
20 Citations (Scopus)

Block of erg current by linoleoylamide, a sleep-inducing agent, in pituitary GH3 cells

Liu, Y-C. & Wu, S-N., 2003 Jan 1, In : European Journal of Pharmacology. 458, 1-2, p. 37-47 11 p.

Research output: Contribution to journalArticle

Sleep
Arachidonic Acid
Calcium-Activated Potassium Channels
linoleoylamide
Neuroblastoma
25 Citations (Scopus)

Differential effects of quercetin, a natural polyphenolic flavonoid, on L-type calcium current in pituitary tumor (GH3) cells and neuronal NG108-15 cells

Wu, S-N., Chiang, H. T., Shen, A. Y. & Lo, Y. K., 2003 May 1, In : Journal of Cellular Physiology. 195, 2, p. 298-308 11 p.

Research output: Contribution to journalArticle

Quercetin
Pituitary Neoplasms
Flavonoids
Tumors
Calcium
14 Citations (Scopus)

Effect of arvanil (N-arachidonoyl-vanillyl-amine), a nonpungent anandamide-capsaicin hybrid, on ion currents in NG108-15 neuronal cells

Lo, Y. K., Chiang, H. T. & Wu, S-N., 2003 Feb 15, In : Biochemical Pharmacology. 65, 4, p. 581-591 11 p.

Research output: Contribution to journalArticle

Capsaicin
Amines
Ions
Ether
Clamping devices
19 Citations (Scopus)
Endothelial cells
Cultured Cells
Coronary Vessels
Endothelial Cells
Masoprocol
96 Citations (Scopus)

Large-conductance Ca2+-activated K+ channels: Physiological role and pharmacology

Wu, S-N., 2003 Apr 1, In : Current Medicinal Chemistry. 10, 8, p. 649-661 13 p.

Research output: Contribution to journalReview article

Calcium-Activated Potassium Channels
Endothelial cells
Neuroendocrine Cells
Endothelial Cells
vinpocetine
6 Citations (Scopus)

Mechanism of carvedilol-induced block of delayed rectifier K+ current in the NG108-15 neuronal cell line

Liu, C. P., Chiang, H. T., Jan, C. R. & Wu, S-N., 2003 Feb 1, In : Drug Development Research. 58, 2, p. 196-208 13 p.

Research output: Contribution to journalArticle

Cell Line
tert-Butylhydroperoxide
Carbonyl Cyanide m-Chlorophenyl Hydrazone
carvedilol
Diazoxide
24 Citations (Scopus)
Oxidants
Retina
Potassium
Epithelial Cells
Thimerosal
23 Citations (Scopus)
Central Muscle Relaxants
Chlorzoxazone
Large-Conductance Calcium-Activated Potassium Channels
Neuroendocrine Cells
Chlormezanone
18 Citations (Scopus)

Stimulatory effects of squamocin, an Annonaceous acetogenin, on Ca2+-activated K+ current in cultured smooth muscle cells of human coronary artery

Wu, S-N., Chiang, H. T., Chang, F. R., Liaw, C. C. & Wu, Y. C., 2003 Jan 1, In : Chemical Research in Toxicology. 16, 1, p. 15-22 8 p.

Research output: Contribution to journalArticle

Acetogenins
Smooth Muscle Myocytes
Muscle
Coronary Vessels
Cells
15 Citations (Scopus)

The mechanism of inhibitory actions of S-petasin, a sesquiterpene of Petasites formosanus, on L-type calcium current in NG108-15 neuronal cells

Wu, S-N., Chen, H. & Lin, Y. L., 2003 Feb 1, In : Planta Medica. 69, 2, p. 118-124 7 p.

Research output: Contribution to journalArticle

Petasites
Sesquiterpenes
Calcium
Electric potential
petasin
2002
29 Citations (Scopus)

Block of L-Type Ca2+ current by beauvericin, a toxic cyclopeptide, in the NG108-15 neuronal cell line

Wu, S-N., Chen, H., Liu, Y-C. & Chiang, H. T., 2002 Jul 2, In : Chemical Research in Toxicology. 15, 6, p. 854-860 7 p.

Research output: Contribution to journalArticle

Cyclic Peptides
Poisons
Cells
Cell Line
Clamping devices
10 Citations (Scopus)

Enhanced activity of Ca2+-activated K+ channels by 1-[2-hydroxy-3-propyl-4-[(1H-tetrazol-5-yl) butoxyl]phenyl] ethanone (LY-171883) in neuroendocrine and neuroblastoma cell lines

Li, P. C., Liang, J. T., Huang, H. T., Lin, P. H. & Wu, S-N., 2002 Jul 20, In : Journal of Cellular Physiology. 192, 2, p. 188-199 12 p.

Research output: Contribution to journalArticle

LY 171883
Calcium-Activated Potassium Channels
Neuroendocrine Cells
Neuroblastoma
Cells
17 Citations (Scopus)

Inhibition of Ca2+-activated and voltage-dependent K+ currents by 2-mercaptophenyl-1,4-naphthoquinone in pituitary GH3 cells: Contribution to its antiproliferative effect

Huang, M. H., Wu, S-N., Chen, C. P. & Shen, A. Y., 2002 Jan 25, In : Life Sciences. 70, 10, p. 1185-1203 19 p.

Research output: Contribution to journalArticle

Electric potential
Vitamin K 3
Cell Proliferation
Cell proliferation
Inhibitory Concentration 50
24 Citations (Scopus)

Inhibitory effect of the plant-extract osthole on L-type calcium current in NG108-15 neuronal cells

Wu, S-N., Lo, Y. K., Chen, C. C., Li, H. F. & Chiang, H. T., 2002 Jan 15, In : Biochemical Pharmacology. 63, 2, p. 199-206 8 p.

Research output: Contribution to journalArticle

Plant Extracts
Calcium
Cyclic GMP
Clamping devices
Electric potential
38 Citations (Scopus)

Stimulation of the BKCa channel in cultured smooth muscle cells of human trachea by magnolol

Wu, S-N., Chen, C. C., Li, H. F., Lo, Y. K., Chen, S. A. & Chiang, H. T., 2002 Jan 30, In : Thorax. 57, 1, p. 67-74 8 p.

Research output: Contribution to journalArticle

Trachea
Smooth Muscle Myocytes
Anti-Asthmatic Agents
Patch-Clamp Techniques
magnolol
2001
28 Citations (Scopus)

Ceramide inhibits the inwardly rectifying potassium current in GH3 lactotrophs

Wu, S-N., Lo, Y. K., Kuo, B. I. T. & Chiang, H. T., 2001 Jan 1, In : Endocrinology. 142, 11, p. 4785-4794 10 p.

Research output: Contribution to journalArticle

Lactotrophs
Ceramides
Potassium
Calcium-Activated Potassium Channels
Dithiothreitol
15 Citations (Scopus)

Characterization of action potential waveform-evoked L-type calcium currents in pituitary GH3 cells

Lo, Y. K., Wu, S-N., Lee, C. T., Li, H. F. & Chiang, H. T., 2001 Aug 2, In : Pflugers Archiv European Journal of Physiology. 442, 4, p. 547-557 11 p.

Research output: Contribution to journalArticle

Action Potentials
Calcium
Bioelectric potentials
Clamping devices
Electric potential
25 Citations (Scopus)

Fenamates stimulate BKCa channel activity in the human osteoblast-like MG-63 cells

Wu, S-N., Jan, C. R. & Chiang, H. T., 2001 Jan 1, In : Journal of Investigative Medicine. 49, 6, p. 522-533 12 p.

Research output: Contribution to journalArticle

Fenamates
Niflumic Acid
Osteoblasts
Human Activities
Meclofenamic Acid
15 Citations (Scopus)

Functional coupling of voltage-dependent L-type Ca 2+ current to Ca 2+ -activated K + current in pituitary GH 3 cells

Wu, S-N., Lo, Y. K., Li, H. F. & Shen, A. Y., 2001 Jan 1, In : Chinese Journal of Physiology. 44, 4, p. 161-167 7 p.

Research output: Contribution to journalArticle

Somatotrophs
tetrandrine
3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester
Apamin
Nimodipine
24 Citations (Scopus)
Large-Conductance Calcium-Activated Potassium Channels
Blood Vessels
Evans Blue
Endothelial Cells
2-methoxyestradiol
1 Citation (Scopus)

On the mechanism of selective action of probucol on the inwardly rectifying potassium current in GH3 lactotrophs

Chiang, H. T. & Wu, S-N., 2001 Jan 1, In : Drug Development Research. 54, 1, p. 1-11 11 p.

Research output: Contribution to journalArticle

Lactotrophs
Probucol
Potassium
Bepridil
Thimerosal
9 Citations (Scopus)

Quantitative analysis of end-tidal carbon dioxide during mechanical and spontaneous ventilation in infants and young children

Hsieh, K. S., Lee, C. L., Lin, C. C., Wu, S-N., Ko, F. Y., Huang, Y. F. & Huang, T. C., 2001 Dec 18, In : Pediatric Pulmonology. 32, 6, p. 453-458 6 p.

Research output: Contribution to journalArticle

Mechanical Ventilators
Artificial Respiration
Carbon Dioxide
Capnography
Pediatrics
34 Citations (Scopus)

Rutaecarpine-induced block of delayed rectifier K + current in NG108-15 neuronal cells

Wu, S-N., Lo, Y., Chen, H., Li, H. F. & Chiang, H. T., 2001 Nov 7, In : Neuropharmacology. 41, 7, p. 834-843 10 p.

Research output: Contribution to journalArticle

Action Potentials
rutecarpine
Quinidine
E 4031
dendrotoxin
22 Citations (Scopus)

Vinpocetine-induced stimulation of calcium-activated potassium currents in rat pituitary GH3 cells

Wu, S-N., Li, H. F. & Chiang, H. T., 2001 Apr 1, In : Biochemical Pharmacology. 61, 7, p. 877-892 16 p.

Research output: Contribution to journalArticle

vinpocetine
Rats
Potassium
Calcium
Clamping devices
2000
28 Citations (Scopus)

Actions of epoxyeicosatrienoic acid on large-conductance Ca2+-activated K+ channels in pituitary GH3 cells

Wu, S-N., Li, H. F. & Chiang, H. T., 2000 Jul 15, In : Biochemical Pharmacology. 60, 2, p. 251-262 12 p.

Research output: Contribution to journalArticle

Calcium-Activated Potassium Channels
Large-Conductance Calcium-Activated Potassium Channels
Acids
14,15-epoxy-5,8,11-eicosatrienoic acid
Neuroendocrine Cells
24 Citations (Scopus)

Characterization of ATP-sensitive potassium channels functionally expressed in pituitary GH3 cells

Wu, S-N., Li, H. F. & Chiang, H. T., 2000 Dec 1, In : Journal of Membrane Biology. 178, 3, p. 205-214 10 p.

Research output: Contribution to journalArticle

KATP Channels
Adenosine Triphosphate
Melitten
Diazoxide
Membrane Potentials
30 Citations (Scopus)

Characterization of inhibition by risperidone of the inwardly rectifying K+ current in pituitary GH3 cells

Wu, S-N., Jan, C. R., Li, H. F. & Chiang, H. T., 2000 Nov 1, In : Neuropsychopharmacology. 23, 6, p. 676-689 14 p.

Research output: Contribution to journalArticle

Risperidone
Large-Conductance Calcium-Activated Potassium Channels
Thioridazine
Metoclopramide
Clozapine
26 Citations (Scopus)
tetrandrine
Large-Conductance Calcium-Activated Potassium Channels
Endothelial Cells
Cell Line
Niflumic Acid