Sheng-Nan Wu &ndash; Research Output

2006

Changes in membrane cholesterol of pituitary tumor (GH ₃ ) cells regulate the activity of large-conductance Ca ²⁺ -activated K ⁺ channels

Lin, M. W., Wu, A. Z., Ting, W. H., Li, C. L., Cheng, K-S. & Wu, S-N., 2006 Jan 1, In : Chinese Journal of Physiology. 49, 1, p. 1-13 13 p.

Research output: Contribution to journal › Article

Cyclodextrins

Pituitary Neoplasms

Large-Conductance Calcium-Activated Potassium Channels

Cholesterol

Membranes

16 Citations (Scopus)

Cocaine-induced inhibition of ATP-sensitive K⁺ channels in rat ventricular myocytes and in heart-derived H9c2 cells

Wu, S-N., Chang, H. D. & Sung, R. J., 2006 May 1, In : Basic and Clinical Pharmacology and Toxicology. 98, 5, p. 510-517 8 p.

Research output: Contribution to journal › Article

KATP Channels

Cocaine

Muscle Cells

Rats

Adenosine Triphosphate

35 Citations (Scopus)

Contribution of BK_Ca-channel activity in human cardiac fibroblasts to electrical coupling of cardiomyocytes-fibroblasts

Wang, Y. J., Sung, R. J., Lin, M. W. & Wu, S-N., 2006 Sep 1, In : Journal of Membrane Biology. 213, 3, p. 175-185 11 p.

Research output: Contribution to journal › Article

Cardiac Myocytes

Human Activities

Fibroblasts

Action Potentials

Gap Junctions

15 Citations (Scopus)

Diethyl pyrocarbonate, a histidine-modifying agent, directly stimulates activity of ATP-sensitive potassium channels in pituitary GH₃ cells

Wu, S-N. & Chang, H. D., 2006 Feb 28, In : Biochemical Pharmacology. 71, 5, p. 615-623 9 p.

Research output: Contribution to journal › Article

Diethyl Pyrocarbonate

KATP Channels

Histidine

Action Potentials

Glyburide

19 Citations (Scopus)

Diosgenin, a plant-derived sapogenin, stimulates Ca²⁺-activated K⁺ current in human cortical HCN-1A neuronal cells

Wang, Y. J., Liu, Y-C., Chang, H. D. & Wu, S-N., 2006 Apr 1, In : Planta Medica. 72, 5, p. 430-436 7 p.

Research output: Contribution to journal › Article

Diosgenin

Sapogenins

Large-Conductance Calcium-Activated Potassium Channels

Neurons

Apamin

33 Citations (Scopus)

Electrophysiological mechanisms of ventricular arrhythmias in relation to Andersen-Tawil syndrome under conditions of reduced I _K1: A simulation study

Sung, R. J., Wu, S-N., Wu, J. S., Chang, H. D. & Luo, C. H., 2006 Dec 18, In : American Journal of Physiology - Heart and Circulatory Physiology. 291, 6

Research output: Contribution to journal › Article

Andersen Syndrome

Cardiac Arrhythmias

Inwardly Rectifying Potassium Channel

Adrenergic Agents

Membrane Potentials

19 Citations (Scopus)

Glucocorticoids stimulate the activity of large-conductance Ca ²⁺-activated K⁺ channels in pituitary GH₃ and AtT-20 cells via a non-genomic mechanism

Huang, M. H., So, E. C., Liu, Y-C. & Wu, S-N., 2006 Feb 1, In : Steroids. 71, 2, p. 129-140 12 p.

Research output: Contribution to journal › Article

Dexamethasone

Glucocorticoids

Mifepristone

Glyburide

Glucocorticoid Receptors

23 Citations (Scopus)

Pharmacological roles of the large-conductance calcium-activated potassium channel

Wu, S. N., Wu, A. Z. & Lin, M. W., 2006 May 1, In : Current Topics in Medicinal Chemistry. 6, 10, p. 1025-1030 6 p.

Research output: Contribution to journal › Review article

Large-Conductance Calcium-Activated Potassium Channels

Pharmacology

Muscle

Acetogenins

Cells

23 Citations (Scopus)

The opening effect of pregabalin on ATP-sensitive potassium channels in differentiated hippocampal neuron-derived H19-7 cells

Huang, C. W., Huang, C. C. & Wu, S. N., 2006 Apr 1, In : Epilepsia. 47, 4, p. 720-726 7 p.

Research output: Contribution to journal › Article

KATP Channels

Potassium Channels

Adenosine Triphosphate

Neurons

2,4-Dinitrophenol

23 Citations (Scopus)

Tramadol-induced blockade of delayed rectifier potassium current in NG108-15 neuronal cells

Tsai, T. Y., Tsai, Y-C., Wu, S-N. & Liu, Y-C., 2006 Oct 1, In : European Journal of Pain. 10, 7, p. 597-601 5 p.

Research output: Contribution to journal › Article

Tramadol

Potassium

Membrane Potentials

Action Potentials

Inhibitory Concentration 50

2005

8 Citations (Scopus)

BAY 41-2272, a potent activator of soluble guanylyl cyclase, stimulates calcium elevation and calcium-activated potassium current in pituitary GH ₃ cells

Liu, Y-C. & Wu, S-N., 2005 Dec 1, In : Clinical and Experimental Pharmacology and Physiology. 32, 12, p. 1078-1087 10 p.

Research output: Contribution to journal › Article

Somatotrophs

Potassium

Calcium

Soluble Guanylyl Cyclase

3-(4-Amino-5-cyclopropylpyrimidine-2-yl)-1-(2-fluorobenzyl)-1H-pyrazolo(3,4-b)pyridine

7 Citations (Scopus)

Characterization of chromanol 293B-induced block of the delayed-rectifier K⁺ current in heart-derived H9c2 cells

Lo, Y. C., Yang, S. R., Huang, M. H., Liu, Y-C. & Wu, S-N., 2005 Apr 1, In : Life Sciences. 76, 20, p. 2275-2286 12 p.

Research output: Contribution to journal › Article

Apamin

Quinidine

Myoblasts

6-cyano-4-(N-ethylsulfonyl-N-methylamino)-3-hydroxy-2,2-dimethylchromane

Inhibitory Concentration 50

29 Citations (Scopus)

Inhibitory action of L-type Ca²⁺ current by paeoniflorin, a major constituent of peony root, in NG108-15 neuronal cells

Tsai, T. Y., Sheng, N. W., Liu, Y. C., Wu, A. Z. & Tsai, Y. C., 2005 Oct 31, In : European Journal of Pharmacology. 523, 1-3, p. 16-24 9 p.

Research output: Contribution to journal › Article

Paeonia

Action Potentials

peoniflorin

Ions

Purinergic P1 Receptors

11 Citations (Scopus)

Properties of BK_Ca channels in oral keratinocytes

Shieh, D-B., Yang, S. R., Shi, X. Y., Wu, Y. N. & Wu, S-N., 2005 May 1, In : Journal of Dental Research. 84, 5, p. 468-473 6 p.

Research output: Contribution to journal › Article

Keratinocytes

Propolis

Apamin

Patch-Clamp Techniques

Ion Channels

Sodium cyanate-induced opening of calcium-activated potassium currents in hippocampal neuron-derived H19-7 cells

Huang, C-W., Huang, C-C., Huang, M. H., Wu, S-N. & Hsieh, Y. J., 2005 Mar 29, In : Neuroscience Letters. 377, 2, p. 110-114 5 p.

Research output: Contribution to journal › Article

Potassium

Calcium

Neurons

Large-Conductance Calcium-Activated Potassium Channels

Poisons

12 Citations (Scopus)

Stimulatory actions of thymol, a natural product, on Ca²⁺- activated K⁺ current in pituitary GH₃ cells

Huang, M. H., Wu, S. N. & Shen, A. Y., 2005 Dec 1, In : Planta Medica. 71, 12, p. 1093-1098 6 p.

Research output: Contribution to journal › Article

Thymol

Biological Products

Large-Conductance Calcium-Activated Potassium Channels

Menthol

Calcium-Activated Potassium Channels

11 Citations (Scopus)

Stretch-stimulated activity of large conductance calcium-activated potassium channels in human retinal pigment epithelial cells

Sheu, S. J., Wu, S-N. & Hu, D. N., 2005 Dec 1, In : Journal of Ocular Pharmacology and Therapeutics. 21, 6, p. 429-435 7 p.

Research output: Contribution to journal › Article

Large-Conductance Calcium-Activated Potassium Channels

Retinal Pigments

Epithelial Cells

Membranes

Riluzole

2004

21 Citations (Scopus)

Cilostazol, an Inhibitor of Type 3 Phosphodiesterase, Stimulates Large-Conductance, Calcium-Activated Potassium Channels in Pituitary GH ₃ Cells and Pheochromocytoma PC12 Cells

Wu, S. N., Liu, S. I. & Huang, M. H., 2004 Mar 1, In : Endocrinology. 145, 3, p. 1175-1184 10 p.

Research output: Contribution to journal › Article

Phosphodiesterase 3 Inhibitors

Somatotrophs

Large-Conductance Calcium-Activated Potassium Channels

PC12 Cells

Pheochromocytoma

25 Citations (Scopus)

Inhibitory effect of lamotrigine on A-type potassium current in hippocampal neuron-derived H19-7 cells

Huang, C-W., Huang, C-C., Liu, Y-C. & Wu, S-N., 2004 Jul 1, In : Epilepsia. 45, 7, p. 729-736 8 p.

Research output: Contribution to journal › Article

Potassium

Neurons

4-Aminopyridine

lamotrigine

Tetraethylammonium

10 Citations (Scopus)

Simulations of the cardiac action potential based on the Hodgkin-Huxley kinetics with the use of Microsoft Excel spreadsheets

Wu, S-N., 2004 Mar 31, In : Chinese Journal of Physiology. 47, 1, p. 15-22 8 p.

Research output: Contribution to journal › Article

Action Potentials

Ion Channels

Membrane Potentials

Theoretical Models

Language

31 Citations (Scopus)

Stimulatory actions of caffeic acid phenethyl ester, a known inhibitor of NF-κB activation, on Ca²⁺-activated K⁺ current in pituitary GH₃ cells

Lin, M. W., Yang, S. R., Huang, M. H. & Wu, S. N., 2004 Jun 25, In : Journal of Biological Chemistry. 279, 26, p. 26885-26892 8 p.

Research output: Contribution to journal › Article

Chemical activation

Membrane Potentials

Propolis

Membranes

tert-Butylhydroperoxide

6 Citations (Scopus)

The influence of hypotonicity on large-conductance calcium-activated potassium channels in human retinal pigment epithelial cells

Sheu, S. J., Wu, S. N., Hu, D. N. & Chen, J. F., 2004 Dec 1, In : Journal of Ocular Pharmacology and Therapeutics. 20, 6, p. 563-575 13 p.

Research output: Contribution to journal › Article

Large-Conductance Calcium-Activated Potassium Channels

Retinal Pigments

Epithelial Cells

Hypotonic Solutions

tetrandrine

2003

18 Citations (Scopus)

An Outbreak of Food-borne Illness Due to Methomyl Contamination

Tsai, M. J., Wu, S. N., Cheng, H. A., Wang, S. H. & Chiang, H. T., 2003 Dec 1, In : Journal of Toxicology - Clinical Toxicology. 41, 7, p. 969-973 5 p.

Research output: Contribution to journal › Article

Methomyl

Foodborne Diseases

Disease Outbreaks

Dizziness

Contamination

25 Citations (Scopus)

Behavior of nonselective cation channels and large-conductance Ca²⁺-activated K⁺ channels induced by dynamic changes in membrane stretch in cultured smooth muscle cells of human coronary artery

Wu, S-N., Lin, P. H., Hsieh, K. S., Liu, Y-C. & Chiang, H. T., 2003 Jan 1, In : Journal of Cardiovascular Electrophysiology. 14, 1, p. 44-51 8 p.

Research output: Contribution to journal › Article

Calcium-Activated Potassium Channels

Smooth Muscle Myocytes

Cations

Coronary Vessels

Membranes

28 Citations (Scopus)

Biological Study of Naphthalene Derivatives with Antiinflammatory Activities

Huang, M. H., Wu, S-N., Wang, J. P., Lin, C. H., Lu, S. I., Liao, L. F. & Shen, A. Y., 2003 Dec 1, In : Drug Development Research. 60, 4, p. 261-269 9 p.

Research output: Contribution to journal › Article

methionyl-leucyl-phenylalanine

Muramidase

Acetates

Neutrophils

Anti-Inflammatory Agents

20 Citations (Scopus)

Block of erg current by linoleoylamide, a sleep-inducing agent, in pituitary GH₃ cells

Liu, Y-C. & Wu, S-N., 2003 Jan 1, In : European Journal of Pharmacology. 458, 1-2, p. 37-47 11 p.

Research output: Contribution to journal › Article

Sleep

Arachidonic Acid

Calcium-Activated Potassium Channels

linoleoylamide

Neuroblastoma

27 Citations (Scopus)

Differential effects of quercetin, a natural polyphenolic flavonoid, on L-type calcium current in pituitary tumor (GH₃) cells and neuronal NG108-15 cells

Wu, S-N., Chiang, H. T., Shen, A. Y. & Lo, Y. K., 2003 May 1, In : Journal of Cellular Physiology. 195, 2, p. 298-308 11 p.

Research output: Contribution to journal › Article

Quercetin

Pituitary Neoplasms

Flavonoids

Tumors

Calcium

14 Citations (Scopus)

Effect of arvanil (N-arachidonoyl-vanillyl-amine), a nonpungent anandamide-capsaicin hybrid, on ion currents in NG108-15 neuronal cells

Lo, Y. K., Chiang, H. T. & Wu, S-N., 2003 Feb 15, In : Biochemical Pharmacology. 65, 4, p. 581-591 11 p.

Research output: Contribution to journal › Article

Capsaicin

Amines

Ions

Ether

Clamping devices

19 Citations (Scopus)

Inhibitory action of ICI-182,780, an estrogen receptor antagonist, on BK_Ca channel activity in cultured endothelial cells of human coronary artery

Liu, Y-C., Lo, Y. C., Huang, C-W. & Wu, S-N., 2003 Nov 15, In : Biochemical Pharmacology. 66, 10, p. 2053-2063 11 p.

Research output: Contribution to journal › Article

Endothelial cells

Cultured Cells

Coronary Vessels

Endothelial Cells

Masoprocol

96 Citations (Scopus)

Large-conductance Ca²⁺-activated K⁺ channels: Physiological role and pharmacology

Wu, S-N., 2003 Apr 1, In : Current Medicinal Chemistry. 10, 8, p. 649-661 13 p.

Research output: Contribution to journal › Review article

Calcium-Activated Potassium Channels

Endothelial cells

Neuroendocrine Cells

Endothelial Cells

vinpocetine

6 Citations (Scopus)

Mechanism of carvedilol-induced block of delayed rectifier K⁺ current in the NG108-15 neuronal cell line

Liu, C. P., Chiang, H. T., Jan, C. R. & Wu, S. N., 2003 Feb 1, In : Drug Development Research. 58, 2, p. 196-208 13 p.

Research output: Contribution to journal › Article

Cell Line

tert-Butylhydroperoxide

Carbonyl Cyanide m-Chlorophenyl Hydrazone

carvedilol

Diazoxide

24 Citations (Scopus)

Mechanism of inhibitory actions of oxidizing agents on calcium-activated potassium current in cultured pigment epithelial cells of the human retina

Sheu, S. J. & Wu, S-N., 2003 Mar 1, In : Investigative Ophthalmology and Visual Science. 44, 3, p. 1237-1244 8 p.

Research output: Contribution to journal › Article

Oxidants

Retina

Potassium

Epithelial Cells

Thimerosal

23 Citations (Scopus)

Stimulatory effects of chlorzoxazone, a centrally acting muscle relaxant, on large conductance calcium-activated potassium channels in pituitary GH₃ cells

Liu, Y-C., Lo, Y. K. & Wu, S-N., 2003 Jan 3, In : Brain Research. 959, 1, p. 86-97 12 p.

Research output: Contribution to journal › Article

Central Muscle Relaxants

Chlorzoxazone

Large-Conductance Calcium-Activated Potassium Channels

Neuroendocrine Cells

Chlormezanone

18 Citations (Scopus)

Stimulatory effects of squamocin, an Annonaceous acetogenin, on Ca²⁺-activated K⁺ current in cultured smooth muscle cells of human coronary artery

Wu, S-N., Chiang, H. T., Chang, F. R., Liaw, C. C. & Wu, Y. C., 2003 Jan 1, In : Chemical Research in Toxicology. 16, 1, p. 15-22 8 p.

Research output: Contribution to journal › Article

Acetogenins

Smooth Muscle Myocytes

Muscle

Coronary Vessels

Cells

15 Citations (Scopus)

The mechanism of inhibitory actions of S-petasin, a sesquiterpene of Petasites formosanus, on L-type calcium current in NG108-15 neuronal cells

Wu, S-N., Chen, H. & Lin, Y. L., 2003 Feb 1, In : Planta Medica. 69, 2, p. 118-124 7 p.

Research output: Contribution to journal › Article

Petasites

Sesquiterpenes

Calcium

Electric potential

petasin

2002

30 Citations (Scopus)

Block of L-Type Ca²⁺ current by beauvericin, a toxic cyclopeptide, in the NG108-15 neuronal cell line

Wu, S-N., Chen, H., Liu, Y-C. & Chiang, H. T., 2002 Jul 2, In : Chemical Research in Toxicology. 15, 6, p. 854-860 7 p.

Research output: Contribution to journal › Article

Cyclic Peptides

Poisons

Cells

Cell Line

Clamping devices

10 Citations (Scopus)

Enhanced activity of Ca²⁺-activated K⁺ channels by 1-[2-hydroxy-3-propyl-4-[(1H-tetrazol-5-yl) butoxyl]phenyl] ethanone (LY-171883) in neuroendocrine and neuroblastoma cell lines

Li, P. C., Liang, J. T., Huang, H. T., Lin, P. H. & Wu, S-N., 2002 Jul 20, In : Journal of Cellular Physiology. 192, 2, p. 188-199 12 p.

Research output: Contribution to journal › Article

LY 171883

Calcium-Activated Potassium Channels

Neuroendocrine Cells

Neuroblastoma

Cells

17 Citations (Scopus)

Inhibition of Ca²⁺-activated and voltage-dependent K⁺ currents by 2-mercaptophenyl-1,4-naphthoquinone in pituitary GH₃ cells: Contribution to its antiproliferative effect

Huang, M. H., Wu, S-N., Chen, C. P. & Shen, A. Y., 2002 Jan 25, In : Life Sciences. 70, 10, p. 1185-1203 19 p.

Research output: Contribution to journal › Article

Electric potential

Vitamin K 3

Cell Proliferation

Cell proliferation

Inhibitory Concentration 50

24 Citations (Scopus)

Inhibitory effect of the plant-extract osthole on L-type calcium current in NG108-15 neuronal cells

Wu, S-N., Lo, Y. K., Chen, C. C., Li, H. F. & Chiang, H. T., 2002 Jan 15, In : Biochemical Pharmacology. 63, 2, p. 199-206 8 p.

Research output: Contribution to journal › Article

Plant Extracts

Calcium

Cyclic GMP

Clamping devices

Electric potential

38 Citations (Scopus)

Stimulation of the BK_Ca channel in cultured smooth muscle cells of human trachea by magnolol

Wu, S-N., Chen, C. C., Li, H. F., Lo, Y. K., Chen, S. A. & Chiang, H. T., 2002 Jan 30, In : Thorax. 57, 1, p. 67-74 8 p.

Research output: Contribution to journal › Article

Trachea

Smooth Muscle Myocytes

Anti-Asthmatic Agents

Patch-Clamp Techniques

magnolol

2001

28 Citations (Scopus)

Ceramide inhibits the inwardly rectifying potassium current in GH₃ lactotrophs

Wu, S-N., Lo, Y. K., Kuo, B. I. T. & Chiang, H. T., 2001 Jan 1, In : Endocrinology. 142, 11, p. 4785-4794 10 p.

Research output: Contribution to journal › Article

Lactotrophs

Ceramides

Potassium

Calcium-Activated Potassium Channels

Dithiothreitol

15 Citations (Scopus)

Characterization of action potential waveform-evoked L-type calcium currents in pituitary GH₃ cells

Lo, Y. K., Wu, S. N., Lee, C. T., Li, H. F. & Chiang, H. T., 2001 Aug 2, In : Pflugers Archiv European Journal of Physiology. 442, 4, p. 547-557 11 p.

Research output: Contribution to journal › Article

Action Potentials

Calcium

Bioelectric potentials

Clamping devices

Electric potential

25 Citations (Scopus)

Fenamates stimulate BK_Ca channel activity in the human osteoblast-like MG-63 cells

Wu, S-N., Jan, C. R. & Chiang, H. T., 2001 Jan 1, In : Journal of Investigative Medicine. 49, 6, p. 522-533 12 p.

Research output: Contribution to journal › Article

Fenamates

Niflumic Acid

Osteoblasts

Human Activities

Meclofenamic Acid

15 Citations (Scopus)

Functional coupling of voltage-dependent L-type Ca ²⁺ current to Ca ²⁺ -activated K ⁺ current in pituitary GH ₃ cells

Wu, S-N., Lo, Y. K., Li, H. F. & Shen, A. Y., 2001 Jan 1, In : Chinese Journal of Physiology. 44, 4, p. 161-167 7 p.

Research output: Contribution to journal › Article

Somatotrophs

tetrandrine

3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester

Apamin

Nimodipine

24 Citations (Scopus)

Inhibition of large-conductance calcium-activated potassium channel by 2-methoxyestradiol in cultured vascular endothelial (HUV-EC-C) cells

Chiang, H. T. & Wu, S. N., 2001 Aug 1, In : Journal of Membrane Biology. 182, 3, p. 203-212 10 p.

Research output: Contribution to journal › Article

Large-Conductance Calcium-Activated Potassium Channels

Blood Vessels

Evans Blue

Endothelial Cells

2-methoxyestradiol

1 Citation (Scopus)

On the mechanism of selective action of probucol on the inwardly rectifying potassium current in GH₃ lactotrophs

Chiang, H. T. & Wu, S-N., 2001 Jan 1, In : Drug Development Research. 54, 1, p. 1-11 11 p.

Research output: Contribution to journal › Article

Lactotrophs

Probucol

Potassium

Bepridil

Thimerosal

9 Citations (Scopus)

Quantitative analysis of end-tidal carbon dioxide during mechanical and spontaneous ventilation in infants and young children

Hsieh, K. S., Lee, C. L., Lin, C. C., Wu, S. N., Ko, F. Y., Huang, Y. F. & Huang, T. C., 2001 Dec 18, In : Pediatric Pulmonology. 32, 6, p. 453-458 6 p.

Research output: Contribution to journal › Article

Mechanical Ventilators

Artificial Respiration

Carbon Dioxide

Capnography

Pediatrics

34 Citations (Scopus)

Rutaecarpine-induced block of delayed rectifier K ⁺ current in NG108-15 neuronal cells

Wu, S-N., Lo, Y., Chen, H., Li, H. F. & Chiang, H. T., 2001 Nov 7, In : Neuropharmacology. 41, 7, p. 834-843 10 p.

Research output: Contribution to journal › Article

Action Potentials

rutecarpine

Quinidine

E 4031

dendrotoxin

22 Citations (Scopus)

Vinpocetine-induced stimulation of calcium-activated potassium currents in rat pituitary GH₃ cells

Wu, S-N., Li, H. F. & Chiang, H. T., 2001 Apr 1, In : Biochemical Pharmacology. 61, 7, p. 877-892 16 p.

Research output: Contribution to journal › Article

vinpocetine

Rats

Potassium

Calcium

Clamping devices

2000

28 Citations (Scopus)

Actions of epoxyeicosatrienoic acid on large-conductance Ca²⁺-activated K⁺ channels in pituitary GH₃ cells

Wu, S-N., Li, H. F. & Chiang, H. T., 2000 Jul 15, In : Biochemical Pharmacology. 60, 2, p. 251-262 12 p.

Research output: Contribution to journal › Article

Calcium-Activated Potassium Channels

Large-Conductance Calcium-Activated Potassium Channels

Acids

14,15-epoxy-5,8,11-eicosatrienoic acid

Neuroendocrine Cells