• 3653 Citations
  • 31 h-Index
1989 …2019
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Research Output 1989 2019

  • 3653 Citations
  • 31 h-Index
  • 207 Article
  • 5 Letter
  • 3 Review article
  • 1 Conference article
2004
6 Citations (Scopus)

The influence of hypotonicity on large-conductance calcium-activated potassium channels in human retinal pigment epithelial cells

Sheu, S. J., Wu, S-N., Hu, D. N. & Chen, J. F., 2004 Dec 1, In : Journal of Ocular Pharmacology and Therapeutics. 20, 6, p. 563-575 13 p.

Research output: Contribution to journalArticle

Large-Conductance Calcium-Activated Potassium Channels
Retinal Pigments
Epithelial Cells
Hypotonic Solutions
tetrandrine
2005
8 Citations (Scopus)
Somatotrophs
Potassium
Calcium
Soluble Guanylyl Cyclase
3-(4-Amino-5-cyclopropylpyrimidine-2-yl)-1-(2-fluorobenzyl)-1H-pyrazolo(3,4-b)pyridine
7 Citations (Scopus)

Characterization of chromanol 293B-induced block of the delayed-rectifier K+ current in heart-derived H9c2 cells

Lo, Y. C., Yang, S. R., Huang, M. H., Liu, Y-C. & Wu, S-N., 2005 Apr 1, In : Life Sciences. 76, 20, p. 2275-2286 12 p.

Research output: Contribution to journalArticle

Apamin
Quinidine
Myoblasts
6-cyano-4-(N-ethylsulfonyl-N-methylamino)-3-hydroxy-2,2-dimethylchromane
Inhibitory Concentration 50
29 Citations (Scopus)

Inhibitory action of L-type Ca2+ current by paeoniflorin, a major constituent of peony root, in NG108-15 neuronal cells

Tsai, T. Y., Sheng, N. W., Liu, Y. C., Wu, A. Z. & Tsai, Y. C., 2005 Oct 31, In : European Journal of Pharmacology. 523, 1-3, p. 16-24 9 p.

Research output: Contribution to journalArticle

Paeonia
Action Potentials
peoniflorin
Ions
Purinergic P1 Receptors
11 Citations (Scopus)

Properties of BKCa channels in oral keratinocytes

Shieh, D-B., Yang, S. R., Shi, X. Y., Wu, Y. N. & Wu, S-N., 2005 May 1, In : Journal of Dental Research. 84, 5, p. 468-473 6 p.

Research output: Contribution to journalArticle

Keratinocytes
Propolis
Apamin
Patch-Clamp Techniques
Ion Channels

Sodium cyanate-induced opening of calcium-activated potassium currents in hippocampal neuron-derived H19-7 cells

Huang, C-W., Huang, C-C., Huang, M. H., Wu, S-N. & Hsieh, Y. J., 2005 Mar 29, In : Neuroscience Letters. 377, 2, p. 110-114 5 p.

Research output: Contribution to journalArticle

Potassium
Calcium
Neurons
Large-Conductance Calcium-Activated Potassium Channels
Poisons
12 Citations (Scopus)

Stimulatory actions of thymol, a natural product, on Ca2+- activated K+ current in pituitary GH3 cells

Huang, M. H., Wu, S. N. & Shen, A. Y., 2005 Dec 1, In : Planta Medica. 71, 12, p. 1093-1098 6 p.

Research output: Contribution to journalArticle

Thymol
Biological Products
Large-Conductance Calcium-Activated Potassium Channels
Menthol
Calcium-Activated Potassium Channels
10 Citations (Scopus)
Large-Conductance Calcium-Activated Potassium Channels
Retinal Pigments
Epithelial Cells
Membranes
Riluzole
2006
22 Citations (Scopus)

Changes in membrane cholesterol of pituitary tumor (GH 3 ) cells regulate the activity of large-conductance Ca 2+ -activated K + channels

Lin, M. W., Wu, A. Z., Ting, W. H., Li, C. L., Cheng, K-S. & Wu, S-N., 2006 Jan 1, In : Chinese Journal of Physiology. 49, 1, p. 1-13 13 p.

Research output: Contribution to journalArticle

Cyclodextrins
Pituitary Neoplasms
Large-Conductance Calcium-Activated Potassium Channels
Cholesterol
Membranes
16 Citations (Scopus)

Cocaine-induced inhibition of ATP-sensitive K+ channels in rat ventricular myocytes and in heart-derived H9c2 cells

Wu, S-N., Chang, H. D. & Sung, R. J., 2006 May 1, In : Basic and Clinical Pharmacology and Toxicology. 98, 5, p. 510-517 8 p.

Research output: Contribution to journalArticle

KATP Channels
Cocaine
Muscle Cells
Rats
Adenosine Triphosphate
35 Citations (Scopus)

Contribution of BKCa-channel activity in human cardiac fibroblasts to electrical coupling of cardiomyocytes-fibroblasts

Wang, Y. J., Sung, R. J., Lin, M. W. & Wu, S-N., 2006 Sep 1, In : Journal of Membrane Biology. 213, 3, p. 175-185 11 p.

Research output: Contribution to journalArticle

Cardiac Myocytes
Human Activities
Fibroblasts
Action Potentials
Gap Junctions
15 Citations (Scopus)
Diethyl Pyrocarbonate
KATP Channels
Histidine
Action Potentials
Glyburide
18 Citations (Scopus)

Diosgenin, a plant-derived sapogenin, stimulates Ca2+-activated K+ current in human cortical HCN-1A neuronal cells

Wang, Y. J., Liu, Y-C., Chang, H. D. & Wu, S-N., 2006 Apr 1, In : Planta Medica. 72, 5, p. 430-436 7 p.

Research output: Contribution to journalArticle

Diosgenin
Sapogenins
Large-Conductance Calcium-Activated Potassium Channels
Neurons
Apamin
33 Citations (Scopus)
Andersen Syndrome
Cardiac Arrhythmias
Inwardly Rectifying Potassium Channel
Adrenergic Agents
Membrane Potentials
19 Citations (Scopus)

Glucocorticoids stimulate the activity of large-conductance Ca 2+-activated K+ channels in pituitary GH3 and AtT-20 cells via a non-genomic mechanism

Huang, M. H., So, E. C., Liu, Y-C. & Wu, S-N., 2006 Feb 1, In : Steroids. 71, 2, p. 129-140 12 p.

Research output: Contribution to journalArticle

Dexamethasone
Glucocorticoids
Mifepristone
Glyburide
Glucocorticoid Receptors
23 Citations (Scopus)

Pharmacological roles of the large-conductance calcium-activated potassium channel

Wu, S. N., Wu, A. Z. & Lin, M. W., 2006 May 1, In : Current Topics in Medicinal Chemistry. 6, 10, p. 1025-1030 6 p.

Research output: Contribution to journalReview article

Large-Conductance Calcium-Activated Potassium Channels
Pharmacology
Muscle
Acetogenins
Cells
23 Citations (Scopus)
KATP Channels
Potassium Channels
Adenosine Triphosphate
Neurons
2,4-Dinitrophenol
23 Citations (Scopus)

Tramadol-induced blockade of delayed rectifier potassium current in NG108-15 neuronal cells

Tsai, T. Y., Tsai, Y-C., Wu, S-N. & Liu, Y-C., 2006 Oct 1, In : European Journal of Pain. 10, 7, p. 597-601 5 p.

Research output: Contribution to journalArticle

Tramadol
Potassium
Membrane Potentials
Action Potentials
Inhibitory Concentration 50
2007
22 Citations (Scopus)
zonisamide
Large-Conductance Calcium-Activated Potassium Channels
Anticonvulsants
Neurons
Ions
27 Citations (Scopus)

Glucose and hippocampal neuronal excitability: Role of ATP-sensitive potassium channels

Huang, C-W., Huang, C-C., Cheng, J. T., Tsai, J. J. & Wu, S-N., 2007 May 15, In : Journal of Neuroscience Research. 85, 7, p. 1468-1477 10 p.

Research output: Contribution to journalArticle

KATP Channels
Glucose
Adenosine Triphosphate
Action Potentials
Diazoxide
15 Citations (Scopus)

Identification of two types of ATP-sensitive K+ channels in rat ventricular myocytes

Wu, S-N., Wu, A. Z. & Sung, R. J., 2007 Jan 2, In : Life Sciences. 80, 4, p. 378-387 10 p.

Research output: Contribution to journalArticle

KATP Channels
Muscle Cells
Rats
Adenosine Triphosphate
Dinitrophenols
8 Citations (Scopus)

Inhibition of intermediate-conductance Ca2+-activated K + channel and cytoprotective properties of 4-piperidinomethyl-2- isopropyl-5-methylphenol

Shen, A. Y., Tsai, J. H., Teng, H. C., Huang, M. H. & Wu, S-N., 2007 May 1, In : Journal of Pharmacy and Pharmacology. 59, 5, p. 679-685 7 p.

Research output: Contribution to journalArticle

Calcium-Activated Potassium Channels
Erythrocytes
Clotrimazole
Thymol
HL-60 Cells
25 Citations (Scopus)
Calcium-Activated Potassium Channels
Pituitary Neoplasms
Protein Kinase C
Tumors
Chemical activation

Reliability analysis of physiological phenomena by cardiac action potential model

Luo, C. H., Chen, P. Y., Teng, C. H., Wu, S-N. & Sung, R. J., 2007 Sep 27, In : Proceedings - IEEE International Symposium on Circuits and Systems. p. 2890-2893 4 p., 4253282.

Research output: Contribution to journalConference article

Reliability analysis
Physiology
14 Citations (Scopus)

The activation by estrogen receptor agonists of the BKCa-channel in human cardiac fibroblasts

Wang, Y. J., Lin, M. W., Wu, S-N. & Sung, R. J., 2007 May 1, In : Biochemical Pharmacology. 73, 9, p. 1347-1357 11 p.

Research output: Contribution to journalArticle

Fibroblasts
Estrogens
Chemical activation
Estrogen Receptors
Calcium-Activated Potassium Channels
2008
3 Citations (Scopus)

Bronchodilatory effects of S-isopetasin, an antimuscarinic sesquiterpene of Petasites formosanus, on obstructive airway hyperresponsiveness

Lin, L. H., Huang, T. J., Wang, S. H., Lin, Y. L., Wu, S. N. & Ko, W. C., 2008 Apr 28, In : European Journal of Pharmacology. 584, 2-3, p. 398-404 7 p.

Research output: Contribution to journalArticle

Petasites
Muscarinic Antagonists
Sesquiterpenes
Ipratropium
Muscarinic Receptors
20 Citations (Scopus)

Characterization of aconitine-induced block of delayed rectifier K+ current in differentiated NG108-15 neuronal cells

Lin, M. W., Wang, Y. J., Liu, S. I., Lin, A. A., Lo, Y. C. & Wu, S-N., 2008 May 1, In : Neuropharmacology. 54, 6, p. 912-923 12 p.

Research output: Contribution to journalArticle

Aconitine
Action Potentials
Orphenadrine
Neurons
Poisons
12 Citations (Scopus)
Aconitine
aconitine
Action Potential
Depolarization
Potassium
24 Citations (Scopus)

Diabetic hyperglycemia is associated with the severity of epileptic seizures in adults

Huang, C-W., Tsai, J. J., Ou, H-Y., Wang, S-T., Cheng, J. T., Wu, S-N. & Huang, C-C., 2008 Mar 1, In : Epilepsy Research. 79, 1, p. 71-77 7 p.

Research output: Contribution to journalArticle

Hyperglycemia
Epilepsy
Seizures
Recurrence
Cluster Analysis
9 Citations (Scopus)

Evidence for state-dependent block of DPI 201-106, a synthetic inhibitor of NA+ channel inactivation, on delayed-rectifier K+ current in pituitary tumor (GH3) cells

Wang, Y. J., Lin, M. W., Lin, A. A., Peng, H. & Wu, S-N., 2008 Sep, In : Journal of Physiology and Pharmacology. 59, 3, p. 409-423 15 p.

Research output: Contribution to journalArticle

Pituitary Neoplasms
Action Potentials
Ions
Membrane Potentials
Inhibitory Concentration 50
13 Citations (Scopus)

Potent activation of large-conductance Ca2+-activated K + channels by the diphenylurea 1,3-bis-[2-hydroxy-5-(trifluoromethyl) phenyl]urea (NS1643) in pituitary tumor (GH3) cells

Wu, S. N., Peng, H., Chen, B. S., Wang, Y. J., Wu, P. Y. & Lin, M. W., 2008 Dec 1, In : Molecular Pharmacology. 74, 6, p. 1696-1704 9 p.

Research output: Contribution to journalArticle

Calcium-Activated Potassium Channels
Pituitary Neoplasms
Ether
1,3-bis(2-hydroxy-5-trifluoromethylphenyl)urea
N-phenylurea
37 Citations (Scopus)

Riluzole-induced block of voltage-gated Na+ current and activation of BKCa channels in cultured differentiated human skeletal muscle cells

Wang, Y. J., Lin, M. W., Lin, A. A. & Wu, S-N., 2008 Jan 2, In : Life Sciences. 82, 1-2, p. 11-20 10 p.

Research output: Contribution to journalArticle

Riluzole
Muscle Cells
Muscle
Skeletal Muscle
Chemical activation
4 Citations (Scopus)
Pituitary Neoplasms
Tumors
Coloring Agents
Electric potential
Ions
7 Citations (Scopus)

The mechanisms of propofol-induced block on ion currents in differentiated H9c2 cardiac cells

Liu, Y-C., Wang, Y. J. & Wu, S-N., 2008 Aug 20, In : European Journal of Pharmacology. 590, 1-3, p. 93-98 6 p.

Research output: Contribution to journalArticle

Propofol
Ions
Anesthetics
Pinacidil
Intravenous Anesthetics
32 Citations (Scopus)
Potassium
Sodium
Neurons
Action Potentials
oxcarbazepine
13 Citations (Scopus)

Time-dependent block of ultrarapid-delayed rectifier K+ currents by aconitine, a potent cardiotoxin, in heart-derived H9c2 myoblasts and in neonatal rat ventricular myocytes

Wang, Y. J., Chen, B. S., Lin, M. W., Lin, A. A., Peng, H., Sung, R. J. & Wu, S-N., 2008 Nov 28, In : Toxicological Sciences. 106, 2, p. 454-463 10 p.

Research output: Contribution to journalArticle

Cardiotoxins
Aconitine
Myoblasts
Muscle Cells
Rats
2009
12 Citations (Scopus)

Analytical studies of rapidly inactivating and noninactivating sodium currents in differentiated NG108-15 neuronal cells

Wu, S-N., Chen, B. S., Hsu, T. I., Peng, H., Wu, Y. H. & Lo, Y. C., 2009 Aug 21, In : Journal of Theoretical Biology. 259, 4, p. 828-836 9 p.

Research output: Contribution to journalArticle

Riluzole
action potentials
Sodium
neurons
sodium
38 Citations (Scopus)

Dexmedetomidine, an α2-adrenergic agonist, inhibits neuronal delayed-rectifier potassium current and sodium current

Chen, B. S., Peng, H. & Wu, S-N., 2009 Jan 1, In : British Journal of Anaesthesia. 103, 2, p. 244-254 11 p.

Research output: Contribution to journalArticle

Dexmedetomidine
Adrenergic Agonists
Potassium
Sodium
efaroxan
15 Citations (Scopus)

Diabetic hyperglycemia aggravates seizures and status epilepticus-induced hippocampal damage

Huang, C-W., Cheng, J. T., Tsai, J. J., Wu, S-N. & Huang, C-C., 2009 Feb 24, In : Neurotoxicity research. 15, 1, p. 71-81 11 p.

Research output: Contribution to journalArticle

Status Epilepticus
Streptozocin
Hyperglycemia
Seizures
Rats
17 Citations (Scopus)

Effects of ranolazine, a novel anti-anginal drug, on ion currents and membrane potential in pituitary tumor GH3 cells and NG108-15 neuronal cells

Chen, B. S., Lo, Y. C., Peng, H., Hsu, T. I. & Wu, S-N., 2009 Aug 3, In : Journal of Pharmacological Sciences. 110, 3, p. 295-305 11 p.

Research output: Contribution to journalArticle

Pituitary Neoplasms
Membrane Potentials
Ions
Pharmaceutical Preparations
Calcium-Activated Potassium Channels
13 Citations (Scopus)
etiracetam
Action Potentials
Potassium
Pyrrolidinones
Neurons
25 Citations (Scopus)

The mechanism of the actions of oxaliplatin on ion currents and action potentials in differentiated NG108-15 neuronal cells

Wu, S-N., Chen, B. S., Wu, Y. H., Peng, H. & Chen, L. T., 2009 Jul 1, In : NeuroToxicology. 30, 4, p. 677-685 9 p.

Research output: Contribution to journalArticle

oxaliplatin
Action Potentials
Ions
Riluzole
Bucladesine
10 Citations (Scopus)

Tramadol-induced block of hyperpolarization-activated cation current in rat pituitary lactotrophs

Liu, Y-C., Wang, Y. J., Wu, P. Y. & Wu, S-N., 2009 Feb 1, In : Naunyn-Schmiedeberg's Archives of Pharmacology. 379, 2, p. 127-135 9 p.

Research output: Contribution to journalArticle

Lactotrophs
Tramadol
Cations
Dideoxyadenosine
Propofol
26 Citations (Scopus)
Pyrethrins
Pituitary Neoplasms
Insecticides
Gonadotropin-Releasing Hormone
Neurons
2010
15 Citations (Scopus)

Diazoxide reduces status epilepticus neuron damage in diabetes.

Huang, C-W., Wu, S-N., Cheng, J. T., Tsai, J. J. & Huang, C-C., 2010 Jan 1, In : Neurotoxicity research. 17, 4, p. 305-316 12 p.

Research output: Contribution to journalArticle

Diazoxide
Status Epilepticus
Streptozocin
Medical problems
Neurons
2 Citations (Scopus)
Action Potentials
Neurons
Capsaicin
Sensory Receptor Cells
Magnetic Fields
16 Citations (Scopus)

β-Adrenergic modulation of arrhythmogenesis and identification of targeted sites of antiarrhythmic therapy in Timothy (LQT8) syndrome: A theoretical study

Sung, R. J., Wu, Y. H., Lai, N. H. J., Teng, C. H., Luo, C. H., Tien, H. C., Lo, C. P. & Wu, S-N., 2010 Jan 1, In : American Journal of Physiology - Heart and Circulatory Physiology. 298, 1

Research output: Contribution to journalArticle

Adrenergic Agents
Theoretical Models
Sarcoplasmic Reticulum Calcium-Transporting ATPases
Action Potentials
Cardiac Arrhythmias
2011
19 Citations (Scopus)

Characterization of TRPM8-like channels activated by the cooling agent icilin in the macrophage cell line RAW 264.7

Wu, S-N., Wu, P. Y. & Tsai, M-L., 2011 May 1, In : Journal of Membrane Biology. 241, 1, p. 11-20 10 p.

Research output: Contribution to journalArticle

Macrophages
Cations
icilin
RAW 264.7 Cells
Apamin
7 Citations (Scopus)
Electroporation
Cyclodextrins
Pituitary Neoplasms
Cholesterol
Membranes
2 Citations (Scopus)
Oxidants
Action Potentials
Theoretical Models
Architectural Accessibility
Riluzole