• 3653 Citations
  • 31 h-Index
1989 …2019
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Research Output 1989 2019

  • 3653 Citations
  • 31 h-Index
  • 207 Article
  • 5 Letter
  • 3 Review article
  • 1 Conference article
Article
4 Citations (Scopus)

Huntington mice demonstrate diminished pain response in inflammatory pain model

Lin, Y. C., Hsiao, H. T., Wu, S-N. & Liu, Y-C., 2018 Jan 1, In : Anesthesia and analgesia. 126, 2, p. 661-669 9 p.

Research output: Contribution to journalArticle

Huntington Disease
Pain
Spinal Cord
Spinal Ganglia
Cytokines
29 Citations (Scopus)

IDENTIFICATION OF ADENOSINE RECEPTORS IN HUMAN SPERMATOZOA

Shen, M-R., Linden, J., Chen, SS. S. & Wu, S-N., 1993 Jan 1, In : Clinical and Experimental Pharmacology and Physiology. 20, 7-8, p. 527-534 8 p.

Research output: Contribution to journalArticle

Adenosine-5'-(N-ethylcarboxamide)
Purinergic P1 Receptors
Sperm Motility
Spermatozoa
Adenosine
2 Citations (Scopus)

Identification of minuscule inward currents as precursors to membrane electroporation-induced currents: Real-time prediction of pore appearance

So, E. C., Tsai, K. L., Wu, F. T., Hsu, M. C., Wu, K. C. & Wu, S-N., 2013 Jan 1, In : Cellular Physiology and Biochemistry. 32, 2, p. 402-416 15 p.

Research output: Contribution to journalArticle

Electroporation
Principal Component Analysis
Membranes
Carnitine
Isoflurane
15 Citations (Scopus)

Identification of two types of ATP-sensitive K+ channels in rat ventricular myocytes

Wu, S-N., Wu, A. Z. & Sung, R. J., 2007 Jan 2, In : Life Sciences. 80, 4, p. 378-387 10 p.

Research output: Contribution to journalArticle

KATP Channels
Muscle Cells
Rats
Adenosine Triphosphate
Dinitrophenols
3 Citations (Scopus)

Important modifications by sugammadex, a modified γ-cyclodextrin, of ion currents in differentiated NSC-34 neuronal cells

Hsu, H. T., Lo, Y. C., Huang, Y. M., Tseng, Y. T. & Wu, S-N., 2017 Jan 3, In : BMC Neuroscience. 18, 1, 6.

Research output: Contribution to journalArticle

Cyclodextrins
Ions
Sugammadex
Neuromuscular Blocking Agents
Membranes
14 Citations (Scopus)

Induction of Ca2+ oscillations by vasopressin in the presence of tetraethylammonium chloride in cultured vascular smooth muscle cells

Wu, S-N., Yu, H. S. & Seyama, Y., 1995 Feb 1, In : Journal of biochemistry. 117, 2, p. 309-314 6 p.

Research output: Contribution to journalArticle

Tetraethylammonium
Vasopressins
Vascular Smooth Muscle
Smooth Muscle Myocytes
Muscle
8 Citations (Scopus)

Influence of beta-adrenergic and vagal activity on the effect of exogenous adenosine on supraventricular tachycardia termination

Tai, C. T., Chen, S. A., Chiang, C. E., Lee, S. H., Wen, Z. C., Chang, M. S. & Wu, S-N., 1997 Jun 15, In : American Journal of Cardiology. 79, 12, p. 1628-1631 4 p.

Research output: Contribution to journalArticle

Supraventricular Tachycardia
Adrenergic Agents
Adenosine
Atropine
Isoproterenol
17 Citations (Scopus)

Inhibition of Ca2+-activated and voltage-dependent K+ currents by 2-mercaptophenyl-1,4-naphthoquinone in pituitary GH3 cells: Contribution to its antiproliferative effect

Huang, M. H., Wu, S-N., Chen, C. P. & Shen, A. Y., 2002 Jan 25, In : Life Sciences. 70, 10, p. 1185-1203 19 p.

Research output: Contribution to journalArticle

Electric potential
Vitamin K 3
Cell Proliferation
Cell proliferation
Inhibitory Concentration 50
46 Citations (Scopus)

Inhibition of Ca2+-activated K+ current by clotrimazole in rat anterior pituitary GH3 cells

Wu, S-N., Li, H. F., Jan, C. R. & Shen, A. Y., 1999 Jul 1, In : Neuropharmacology. 38, 7, p. 979-989 11 p.

Research output: Contribution to journalArticle

Clotrimazole
Large-Conductance Calcium-Activated Potassium Channels
Econazole
Ketoconazole
Patch-Clamp Techniques
8 Citations (Scopus)

Inhibition of intermediate-conductance Ca2+-activated K + channel and cytoprotective properties of 4-piperidinomethyl-2- isopropyl-5-methylphenol

Shen, A. Y., Tsai, J. H., Teng, H. C., Huang, M. H. & Wu, S-N., 2007 May 1, In : Journal of Pharmacy and Pharmacology. 59, 5, p. 679-685 7 p.

Research output: Contribution to journalArticle

Calcium-Activated Potassium Channels
Erythrocytes
Clotrimazole
Thymol
HL-60 Cells
24 Citations (Scopus)
Large-Conductance Calcium-Activated Potassium Channels
Blood Vessels
Evans Blue
Endothelial Cells
2-methoxyestradiol
19 Citations (Scopus)
Endothelial cells
Cultured Cells
Coronary Vessels
Endothelial Cells
Masoprocol
29 Citations (Scopus)

Inhibitory action of L-type Ca2+ current by paeoniflorin, a major constituent of peony root, in NG108-15 neuronal cells

Tsai, T. Y., Sheng, N. W., Liu, Y. C., Wu, A. Z. & Tsai, Y. C., 2005 Oct 31, In : European Journal of Pharmacology. 523, 1-3, p. 16-24 9 p.

Research output: Contribution to journalArticle

Paeonia
Action Potentials
peoniflorin
Ions
Purinergic P1 Receptors
15 Citations (Scopus)

Inhibitory action of methadone and its metabolites on erg-mediated K+ current in GH3 pituitary tumor cells

Huang, M. H., Shen, A. Y., Wang, T. S., Wu, H. M., Kang, Y. F., Chen, C. T., Hsu, T. I., Chen, B. S. & Wu, S-N., 2011 Feb 4, In : Toxicology. 280, 1-2, p. 1-9 9 p.

Research output: Contribution to journalArticle

Methadone
Pituitary Neoplasms
Metabolites
Tumors
Cells
3 Citations (Scopus)

Inhibitory actions by ibandronate sodium, a nitrogen-containing bisphosphonate, on calcium-activated potassium channels in Madin-Darby canine kidney cells

Wu, S-N., Chen, H. Z., Chou, Y. H., Huang, Y. M. & Lo, Y. C., 2015 Aug 1, In : Toxicology Reports. 2, p. 1182-1193 12 p.

Research output: Contribution to journalArticle

Calcium-Activated Potassium Channels
Madin Darby Canine Kidney Cells
Diphosphonates
Nitrogen
ibandronic acid
7 Citations (Scopus)
Smooth Muscle Myocytes
Potassium
Ethanol
Vasoconstrictor Agents
Patch-Clamp Techniques
25 Citations (Scopus)

Inhibitory effect of lamotrigine on A-type potassium current in hippocampal neuron-derived H19-7 cells

Huang, C-W., Huang, C-C., Liu, Y-C. & Wu, S-N., 2004 Jul 1, In : Epilepsia. 45, 7, p. 729-736 8 p.

Research output: Contribution to journalArticle

Potassium
Neurons
4-Aminopyridine
lamotrigine
Tetraethylammonium
10 Citations (Scopus)

Inhibitory effect of memantine, an NMDA-receptor antagonist, on electoporation-induced inward currents in pituitary GH3 cells

Wu, S-N., Huang, H. C., Yeh, C. C., Yang, W. H. & Lo, Y. C., 2011 Feb 18, In : Biochemical and Biophysical Research Communications. 405, 3, p. 508-513 6 p.

Research output: Contribution to journalArticle

Memantine
Glyburide
Induced currents
N-Methyl-D-Aspartate Receptors
Adenosine Triphosphate
24 Citations (Scopus)

Inhibitory effect of the plant-extract osthole on L-type calcium current in NG108-15 neuronal cells

Wu, S-N., Lo, Y. K., Chen, C. C., Li, H. F. & Chiang, H. T., 2002 Jan 15, In : Biochemical Pharmacology. 63, 2, p. 199-206 8 p.

Research output: Contribution to journalArticle

Plant Extracts
Calcium
Cyclic GMP
Clamping devices
Electric potential
44 Citations (Scopus)

Inhibitory effects of berberine on voltage- and calcium-activated potassium currents in human myeloma cells

Wu, S-N., Yu, H. S., Jan, C. R., Li, H. F. & Yu, C. L., 1998 May 15, In : Life Sciences. 62, 25, p. 2283-2294 12 p.

Research output: Contribution to journalArticle

Berberine
Potassium
Calcium
Electric potential
Inhibitory Concentration 50
7 Citations (Scopus)

Investigations into the Correlation Properties of Membrane Electroporation-Induced Inward Currents: Prediction of Pore Formation

Wu, S-N., Yeh, C. C., Wu, P. Y., Huang, H. C. & Tsai, M-L., 2012 Jan 1, In : Cell Biochemistry and Biophysics. 62, 1, p. 211-220 10 p.

Research output: Contribution to journalArticle

Electroporation
Induced currents
Membranes
Chloroquine
Somatotrophs
3 Citations (Scopus)

Investigations on contribution of glial inwardly-rectifying K+ current to membrane potential and ion flux: An experimental and theoretical study

Wu, S-N., Huang, Y. M., Kao, C. A., Chen, B. S. & Lo, Y. C., 2015 Jan 1, In : Kaohsiung Journal of Medical Sciences. 31, 1, p. 9-17 9 p.

Research output: Contribution to journalArticle

Neuroglia
Membrane Potentials
Theoretical Models
Ions
Neurons
25 Citations (Scopus)

ionic mechanisms of tetradrine in cultured rat aortic smooth muscle cells

Wu, S-N., Hwang, T. L., Jan, C. R. & Tseng, C. J., 1997 May 30, In : European Journal of Pharmacology. 327, 2-3, p. 233-238 6 p.

Research output: Contribution to journalArticle

tetrandrine
Smooth Muscle Myocytes
Vascular Smooth Muscle
Stephania
3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester
2 Citations (Scopus)

Kinetic studies of protein kinase A in rat liver during early sepsis

Sun, Y. M., Yang, S. L., Jin, Y. W., Wu, S-N., Hsu, H. K. & Liu, M. S., 1993 Jan 1, In : Gaoxiong yi xue ke xue za zhi = The Kaohsiung journal of medical sciences. 9, 2, p. 80-88 9 p.

Research output: Contribution to journalArticle

Cyclic AMP-Dependent Protein Kinases
Sepsis
Liver
Blood Glucose
Punctures

Kinetic studies of protein kinase A in rat liver during late sepsis

Jin, Y. W., Yang, S. L., Hsu, H. K., Wu, S-N. & Liu, M. S., 1992 Jan 1, In : Gaoxiong yi xue ke xue za zhi = The Kaohsiung journal of medical sciences. 8, 9, p. 460-470 11 p.

Research output: Contribution to journalArticle

Cyclic AMP-Dependent Protein Kinases
Sepsis
Cyclic AMP-Dependent Protein Kinase Type I
Liver
Adenosine Monophosphate
11 Citations (Scopus)

La 3+ Inhibits the UTP-induced Ca 2+ Mobilization in MDCK Cells

Jan, C. R., Ho, C. M., Wu, S-N., Huang, J. K. & Tseng, C. J., 1998 Mar 31, In : Chinese Journal of Physiology. 41, 1, p. 59-64 6 p.

Research output: Contribution to journalArticle

Uridine Triphosphate
Madin Darby Canine Kidney Cells
Fluorometry
Inositol 1,4,5-Trisphosphate
Thapsigargin
6 Citations (Scopus)

Mechanism of carvedilol-induced block of delayed rectifier K+ current in the NG108-15 neuronal cell line

Liu, C. P., Chiang, H. T., Jan, C. R. & Wu, S-N., 2003 Feb 1, In : Drug Development Research. 58, 2, p. 196-208 13 p.

Research output: Contribution to journalArticle

Cell Line
tert-Butylhydroperoxide
Carbonyl Cyanide m-Chlorophenyl Hydrazone
carvedilol
Diazoxide
24 Citations (Scopus)
Oxidants
Retina
Potassium
Epithelial Cells
Thimerosal
81 Citations (Scopus)

Mechanism of lanthanum inhibition of extracellular ATP-evoked calcium mobilization in MDCK cells

Jan, C. R., Ho, C. M., Wu, S-N., Huang, J. K. & Tseng, C. J., 1998 Jan 2, In : Life Sciences. 62, 6, p. 533-540 8 p.

Research output: Contribution to journalArticle

Lanthanum
Madin Darby Canine Kidney Cells
Adenosine Triphosphate
Calcium
Purinergic P2 Receptors
26 Citations (Scopus)

Mechanism of rise and decay of 2,5-di-tert-butylhydroquinone-induced Ca2+ signals in Madin Darby canine kidney cells

Jan, C. R., Ho, C. M., Wu, S-N. & Tseng, C. J., 1999 Jan 15, In : European Journal of Pharmacology. 365, 1, p. 111-117 7 p.

Research output: Contribution to journalArticle

Madin Darby Canine Kidney Cells
Endoplasmic Reticulum
1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole
Thapsigargin
Oligomycins
61 Citations (Scopus)

Mechanism of rise and decay of thapsigargin-evoked calcium signals in MDCK cells

Jan, C. R., Ho, C. M., Wu, S-N. & Tseng, C. J., 1998 Dec 18, In : Life Sciences. 64, 4, p. 259-267 9 p.

Research output: Contribution to journalArticle

Madin Darby Canine Kidney Cells
Thapsigargin
Calcium
1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole
Econazole
7 Citations (Scopus)

Mechanisms of Rise and Decay of ADP-Evoked Calcium Signal in MDCK Cells

Jan, C. R., Ho, C. M., Wu, S-N. & Tseng, C. J., 1998 Jun 30, In : Chinese Journal of Physiology. 41, 2, p. 67-73 7 p.

Research output: Contribution to journalArticle

Madin Darby Canine Kidney Cells
Adenosine Diphosphate
Calcium
Adenosine Triphosphate
Fluorometry
8 Citations (Scopus)
Cyclodextrins
Neurons
Neuroendocrine Cells
Bucladesine
Oligosaccharides
32 Citations (Scopus)

Molecular mechanism of cibenzoline-induced anticholinergic action in single atrial myocytes: Comparison with effect of disopyramide

Wu, S-N., Nakajima, T., Yamashita, T., Hamada, E., Hazama, H., Iwasawa, K., Omata, M. & Kurachi, Y., 1994 Jan 1, In : Journal of Cardiovascular Pharmacology. 23, 4, p. 618-623 6 p.

Research output: Contribution to journalArticle

Disopyramide
Cholinergic Antagonists
Guanosine Triphosphate
Muscle Cells
Guanosine 5'-O-(3-Thiotriphosphate)
3 Citations (Scopus)
Miniature Postsynaptic Potentials
Rotenone
Electron Transport
Neurons
Niflumic Acid
49 Citations (Scopus)
1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole
Madin Darby Canine Kidney Cells
Thapsigargin
Endoplasmic Reticulum
imidazole
46 Citations (Scopus)
Econazole
Thapsigargin
Calcium Signaling
Calcium
Fura-2
4 Citations (Scopus)
Acid Sensing Ion Channels
Somatotrophs
Neurons
Large-Conductance Calcium-Activated Potassium Channels
Chemical activation
7 Citations (Scopus)

Negative dromotropism of adenosine under beta-adrenergic stimulation with isoproterenol

Lai, W. T., Wu, S-N. & Sung, R. J., 1992 Dec 1, In : The American Journal of Cardiology. 70, 18, p. 1427-1431 5 p.

Research output: Contribution to journalArticle

Isoproterenol
Adrenergic Agents
Adenosine
Atrioventricular Node
Supraventricular Tachycardia
10 Citations (Scopus)

Nifedipine, verapamil and diltiazem block shock-wave-induced rises in cytosolic calcium in MDCK cells

Jan, C. R., Chen, W. C., Wu, S-N. & Tseng, C. J., 1998 Jan 1, In : Chinese Journal of Physiology. 41, 4, p. 181-188 8 p.

Research output: Contribution to journalArticle

Madin Darby Canine Kidney Cells
Diltiazem
Nifedipine
Transferases
Verapamil
1 Citation (Scopus)

On the mechanism of selective action of probucol on the inwardly rectifying potassium current in GH3 lactotrophs

Chiang, H. T. & Wu, S-N., 2001 Jan 1, In : Drug Development Research. 54, 1, p. 1-11 11 p.

Research output: Contribution to journalArticle

Lactotrophs
Probucol
Potassium
Bepridil
Thimerosal
4 Citations (Scopus)
Cyclooxygenase 2
Analgesics
Ions
parecoxib
Cyclooxygenase 2 Inhibitors
5 Citations (Scopus)

Pioglitazone, a PPAR-γ activator, stimulates BK Ca but suppresses IK M in hippocampal neurons

Chen, T. S., Lai, M. C., Hung, T. Y., Lin, K. M., Huang, C-W. & Wu, S-N., 2018 Aug 29, In : Frontiers in Pharmacology. 9, AUG, 977.

Research output: Contribution to journalArticle

pioglitazone
Peroxisome Proliferator-Activated Receptors
Neurons
Large-Conductance Calcium-Activated Potassium Channels
Apamin
13 Citations (Scopus)

Potent activation of large-conductance Ca2+-activated K + channels by the diphenylurea 1,3-bis-[2-hydroxy-5-(trifluoromethyl) phenyl]urea (NS1643) in pituitary tumor (GH3) cells

Wu, S. N., Peng, H., Chen, B. S., Wang, Y. J., Wu, P. Y. & Lin, M. W., 2008 Dec 1, In : Molecular Pharmacology. 74, 6, p. 1696-1704 9 p.

Research output: Contribution to journalArticle

Calcium-Activated Potassium Channels
Pituitary Neoplasms
Ether
1,3-bis(2-hydroxy-5-trifluoromethylphenyl)urea
N-phenylurea

Potentiation of muscarinic K+ channel activity by PD 81,723 in rat atrial myocytes

Wu, S. N., Lee, H. F. & Tseng, C. J., 1998 Mar 20, In : FASEB Journal. 12, 5, p. A713

Research output: Contribution to journalArticle

potassium channels
adenosine
myocytes
Muscle Cells
Cholinergic Agents
25 Citations (Scopus)
Calcium-Activated Potassium Channels
Pituitary Neoplasms
Protein Kinase C
Tumors
Chemical activation
7 Citations (Scopus)

Pregabalin Attenuates Excitotoxicity in Diabetes

Huang, C-W., Lai, M. C., Cheng, J. T., Tsai, J. J., Huang, C-C. & Wu, S-N., 2013 Jun 13, In : PloS one. 8, 6, e65154.

Research output: Contribution to journalArticle

seizures
Medical problems
diabetes
Rats
Seizures
11 Citations (Scopus)

Properties of BKCa channels in oral keratinocytes

Shieh, D-B., Yang, S. R., Shi, X. Y., Wu, Y. N. & Wu, S-N., 2005 May 1, In : Journal of Dental Research. 84, 5, p. 468-473 6 p.

Research output: Contribution to journalArticle

Keratinocytes
Propolis
Apamin
Patch-Clamp Techniques
Ion Channels
9 Citations (Scopus)

Quantitative analysis of end-tidal carbon dioxide during mechanical and spontaneous ventilation in infants and young children

Hsieh, K. S., Lee, C. L., Lin, C. C., Wu, S. N., Ko, F. Y., Huang, Y. F. & Huang, T. C., 2001 Dec 18, In : Pediatric Pulmonology. 32, 6, p. 453-458 6 p.

Research output: Contribution to journalArticle

Mechanical Ventilators
Artificial Respiration
Carbon Dioxide
Capnography
Pediatrics
14 Citations (Scopus)

Rate-dependent properties of adenosine-induced negative dromotropism in humans

Lai, W. T., Lee, C. S. & Wu, S-N., 1994 Jan 1, In : Circulation. 90, 4 I, p. 1832-1839 8 p.

Research output: Contribution to journalArticle

Adenosine
Propranolol
Aminophylline
Intravenous Infusions
Heart Rate