• 3653 Citations
  • 31 h-Index
1989 …2019
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Research Output 1989 2019

  • 3653 Citations
  • 31 h-Index
  • 207 Article
  • 5 Letter
  • 3 Review article
  • 1 Conference article
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Article
2019
Bisoprolol
neurons
Neurons
Depolarization
Clamping devices

Characterization of Perturbing Actions by Verteporfin, a Benzoporphyrin Photosensitizer, on Membrane Ionic Currents

Huang, M. H., Liu, P. Y. & Wu, S. N., 2019 Aug 22, In : Frontiers in Chemistry. 7, 566.

Research output: Contribution to journalArticle

Open Access
Photosensitizing Agents
Membranes
Lighting
verteporfin
Dithiothreitol
1 Citation (Scopus)
ivabradine
Neurons
linopirdine
Endocrine Cells
Reducing Agents
Kaurane Diterpenes
Croton
Diterpenes
Euphorbiaceae
Euphorbia

Effectiveness of nalbuphine, a κ-opioid receptor agonist and μ-opioid receptor antagonist, in the inhibition of INa, IK(M), and IK(erg) unlinked to interaction with opioid receptors

Liu, Y. Y., Hsiao, H. T., Wang, J. C. F., Liu, Y. C. & Wu, S-N., 2019 Sep 1, In : Drug Development Research. 80, 6, p. 846-856 11 p.

Research output: Contribution to journalArticle

Nalbuphine
Narcotic Antagonists
Opioid Receptors
Inhibitory Concentration 50
Neurons
2 Citations (Scopus)

Evidence for effective multiple K+current inhibitions by Tolvaptan, a non-peptide antagonist of vasopressin V2 receptor

Lu, T. L., Chang, W. T., Chan, C. H. & Wu, S-N., 2019 Jan 1, In : Frontiers in Pharmacology. 10, FEB, 76.

Research output: Contribution to journalArticle

Open Access
Vasopressin Receptors
flupirtine
Inappropriate ADH Syndrome
Calcium-Activated Potassium Channels
Neuroendocrine Cells
4 Citations (Scopus)
Cyclooxygenase 2
Analgesics
Ions
parecoxib
Cyclooxygenase 2 Inhibitors
1 Citation (Scopus)

The biochemical and electrophysiological profiles of amniotic fluid-derived stem cells following Wnt signaling modulation cardiac differentiation

Liu, Y. W., Fang, Y. H., Su, C. T., Hwang, S. M., Liu, P. Y. & Wu, S-N., 2019 Dec 1, In : Cell Death Discovery. 5, 1, 59.

Research output: Contribution to journalArticle

Open Access
Amniotic Fluid
Stem Cells
Cardiac Myocytes
Action Potentials
Myosin Light Chains
2 Citations (Scopus)

The Protective Role of Peroxisome Proliferator-Activated Receptor-Gamma in Seizure and Neuronal Excitotoxicity

Hung, T. Y., Chu, F. L., Wu, D. C., Wu, S-N. & Huang, C-W., 2019 Aug 15, In : Molecular Neurobiology. 56, 8, p. 5497-5506 10 p.

Research output: Contribution to journalArticle

pioglitazone
Peroxisome Proliferator-Activated Receptors
PPAR gamma
Seizures
Pilocarpine
2018
Angiotensin II Type 1 Receptor Blockers
Cardiac Myocytes
Potassium
Sodium
Action Potentials
5 Citations (Scopus)

Defective trafficking of Kv2.1 channels in MPTP-induced nigrostriatal degeneration

Chao, R. Y., Cheng, C. H., Wu, S-N. & Chen, P., 2018 Feb 1, In : Journal of Neurochemistry. 144, 4, p. 483-497 15 p.

Research output: Contribution to journalArticle

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Parkinson Disease
Dopaminergic Neurons
Protein Transport
Neurons
2 Citations (Scopus)
Chemical activation
Cells
Cell Line
Neuroendocrine Cells
Monoterpenes
4 Citations (Scopus)

Huntington mice demonstrate diminished pain response in inflammatory pain model

Lin, Y. C., Hsiao, H. T., Wu, S-N. & Liu, Y-C., 2018 Jan 1, In : Anesthesia and analgesia. 126, 2, p. 661-669 9 p.

Research output: Contribution to journalArticle

Huntington Disease
Pain
Spinal Cord
Spinal Ganglia
Cytokines
3 Citations (Scopus)
Miniature Postsynaptic Potentials
Rotenone
Electron Transport
Neurons
Niflumic Acid
4 Citations (Scopus)
Acid Sensing Ion Channels
Somatotrophs
Neurons
Large-Conductance Calcium-Activated Potassium Channels
Chemical activation
5 Citations (Scopus)

Pioglitazone, a PPAR-γ activator, stimulates BK Ca but suppresses IK M in hippocampal neurons

Chen, T. S., Lai, M. C., Hung, T. Y., Lin, K. M., Huang, C-W. & Wu, S-N., 2018 Aug 29, In : Frontiers in Pharmacology. 9, AUG, 977.

Research output: Contribution to journalArticle

pioglitazone
Peroxisome Proliferator-Activated Receptors
Neurons
Large-Conductance Calcium-Activated Potassium Channels
Apamin
2 Citations (Scopus)

Sodium Metabisulfite: Effects on Ionic Currents and Excitotoxicity

Lai, M. C., Hung, T. Y., Lin, K. M., Sung, P-S., Wu, S. J., Yang, C. S., Wu, Y-J., Tsai, J. J., Wu, S-N. & Huang, C-W., 2018 Jul 1, In : Neurotoxicity Research. 34, 1

Research output: Contribution to journalArticle

Sodium Channels
Pilocarpine
Clamping devices
Neurons
Rats

Stimulatory action of telmisartan, an antagonist of angiotensin II receptor, on voltage-gated Na + current: Experimental and theoretical studies

Chang, T. T., Yang, C. J., Lee, Y. C. & Wu, S-N., 2018 Jan 1, In : Chinese Journal of Physiology. 61, 1, p. 1-13 13 p.

Research output: Contribution to journalArticle

Angiotensin Receptor Antagonists
Theoretical Models
Neurons
Neuroendocrine Cells
Peroxisome Proliferator-Activated Receptors
4 Citations (Scopus)

The comprehensive electrophysiological study of curcuminoids on delayed-rectifier K+ currents in insulin-secreting cells

Kuo, P-C., Yang, C. J., Lee, Y. C., Chen, P., Liu, Y-C. & Wu, S-N., 2018 Jan 15, In : European Journal of Pharmacology. 819, p. 233-241 9 p.

Research output: Contribution to journalArticle

Curcumin
Insulin-Secreting Cells
Insulin
Membrane Potentials
Nicorandil

The Novel Effect of Immunomodulator-Glatiramer Acetate on Epileptogenesis and Epileptic Seizures

Lai, M. C., Lin, K. M., Yeh, P. S., Wu, S-N. & Huang, C-W., 2018 Oct 1, In : Cellular Physiology and Biochemistry. 50, 1, p. 169-178 10 p.

Research output: Contribution to journalArticle

Immunologic Factors
Epilepsy
Seizures
Interleukin-1
Pilocarpine
2017
3 Citations (Scopus)

Important modifications by sugammadex, a modified γ-cyclodextrin, of ion currents in differentiated NSC-34 neuronal cells

Hsu, H. T., Lo, Y. C., Huang, Y. M., Tseng, Y. T. & Wu, S-N., 2017 Jan 3, In : BMC Neuroscience. 18, 1, 6.

Research output: Contribution to journalArticle

Cyclodextrins
Ions
Sugammadex
Neuromuscular Blocking Agents
Membranes
10 Citations (Scopus)

Stimulatory actions of a novel thiourea derivative on large-conductance, calcium-activated potassium channels

Wu, S-N., Chern, J. H., Shen, S., Chen, H. H., Hsu, Y. T., Lee, C. C., Chan, M. H., Lai, M. C. & Shie, F. S., 2017 Dec 1, In : Journal of Cellular Physiology. 232, 12, p. 3409-3421 13 p.

Research output: Contribution to journalArticle

Large-Conductance Calcium-Activated Potassium Channels
Thiourea
Derivatives
Calcium-Activated Potassium Channels
Tolbutamide
4 Citations (Scopus)

Synergistic inhibition of delayed rectifier K + and voltage-gated Na + currents by artemisinin in pituitary tumor (GH 3 ) cells

So, E. C., Wu, S-N., Wu, P-C., Chen, H. Z. & Yang, C. J., 2017 Jun 1, In : Cellular Physiology and Biochemistry. 41, 5, p. 2053-2066 14 p.

Research output: Contribution to journalArticle

Pituitary Neoplasms
Action Potentials
Iloprost
Neuroendocrine Cells
Endocrine Cells
2016
15 Citations (Scopus)

Estrogen ameliorates microglial activation by inhibiting the Kir2.1 inward-rectifier K+ channel

Wu, S. Y., Chen, Y-W., Tsai, S. F., Wu, S-N., Shih, Y. H., Jiang-Shieh, Y. F., Yang, T. T. & Kuo, Y-M., 2016 Mar 10, In : Scientific reports. 6, 22864.

Research output: Contribution to journalArticle

Inwardly Rectifying Potassium Channel
Estradiol
Dopaminergic Neurons
Estrogens
Parkinson Disease
5 Citations (Scopus)

Evidence for the Inhibition by Temozolomide, an Imidazotetrazine Family Alkylator, of Intermediate-Conductance Ca 2+ -Activated K + Channels in Glioma Cells

Yeh, P. S., Wu, S. J., Hung, T. Y., Huang, Y. M., Hsu, C. W., Sze, C-I., Hsieh, Y. J., Huang, C-W. & Wu, S-N., 2016 Jan 1, In : Cellular Physiology and Biochemistry. 38, 5, p. 1727-1742 16 p.

Research output: Contribution to journalArticle

temozolomide
Alkylating Agents
Glioma
Small Interfering RNA
Chlorzoxazone
8 Citations (Scopus)

Resveratrol attenuates cortical neuron activity: Roles of large conductance calcium-activated potassium channels and voltage-gated sodium channels

Wang, Y. J., Chan, M. H., Chen, L., Wu, S-N. & Chen, H. H., 2016 May 21, In : Journal of biomedical science. 23, 1, 47.

Research output: Contribution to journalArticle

Large-Conductance Calcium-Activated Potassium Channels
Voltage-Gated Sodium Channels
Neurons
Action Potentials
Sodium
2015
7 Citations (Scopus)

Actions of KMUP-1, a xanthine and piperazine derivative, on voltage-gated Na+ and Ca2+-activated K+ currents in GH3 pituitary tumour cells

Lo, Y. C., Tseng, Y. T., Liu, C. M., Wu, B. N. & Wu, S-N., 2015 Nov 1, In : British Journal of Pharmacology. 172, 21, p. 5110-5122 13 p.

Research output: Contribution to journalArticle

Xanthine
Pituitary Neoplasms
Ions
Calcium-Activated Potassium Channels
Architectural Accessibility
6 Citations (Scopus)

Arecoline inhibits intermediate-conductance calcium-activated potassium channels in human glioblastoma cell lines

So, E. C., Huang, Y. M., Hsing, C. H., Liao, Y. K. & Wu, S-N., 2015 Jul 5, In : European Journal of Pharmacology. 758, p. 177-187 11 p.

Research output: Contribution to journalArticle

Intermediate-Conductance Calcium-Activated Potassium Channels
Arecoline
Glioblastoma
Cell Line
Calcium-Activated Potassium Channels
24 Citations (Scopus)

Defined MicroRNAs Induce Aspects of Maturation in Mouse and Human Embryonic-Stem-Cell-Derived Cardiomyocytes

Lee, D. S., Chen, J. H., Lundy, D. J., Liu, C. H., Hwang, S. M., Pabon, L., Shieh, R. C., Chen, C. C., Wu, S-N., Yan, Y. T., Lee, S. T., Chiang, P-M., Chien, S., Murry, C. E. & Hsieh, P. C. H., 2015 Sep 29, In : Cell Reports. 12, 12, p. 1960-1967 8 p.

Research output: Contribution to journalArticle

Stem cells
MicroRNAs
Cardiac Myocytes
Embryonic Stem Cells
Endothelial cells

Evaluation of microvasculature at the auditory midbrain-the benefits of sectioning at a tangential angle

So, E. C., Lu, H. P., Hsing, C. H., Wu, S-N., Chang, Y. K. & Poon, P. W. F., 2015 Jan 1, In : Microscopy Research and Technique. 78, 1, p. 105-110 6 p.

Research output: Contribution to journalArticle

Inferior Colliculi
Mesencephalon
Microvessels
Blood Vessels
Brain
3 Citations (Scopus)

Inhibitory actions by ibandronate sodium, a nitrogen-containing bisphosphonate, on calcium-activated potassium channels in Madin-Darby canine kidney cells

Wu, S-N., Chen, H. Z., Chou, Y. H., Huang, Y. M. & Lo, Y. C., 2015 Aug 1, In : Toxicology Reports. 2, p. 1182-1193 12 p.

Research output: Contribution to journalArticle

Calcium-Activated Potassium Channels
Madin Darby Canine Kidney Cells
Diphosphonates
Nitrogen
ibandronic acid
3 Citations (Scopus)

Investigations on contribution of glial inwardly-rectifying K+ current to membrane potential and ion flux: An experimental and theoretical study

Wu, S-N., Huang, Y. M., Kao, C. A., Chen, B. S. & Lo, Y. C., 2015 Jan 1, In : Kaohsiung Journal of Medical Sciences. 31, 1, p. 9-17 9 p.

Research output: Contribution to journalArticle

Neuroglia
Membrane Potentials
Theoretical Models
Ions
Neurons
5 Citations (Scopus)
oxaliplatin
Platinum
Glioma
4 Citations (Scopus)

The inhibitory actions by lacosamide, a functionalized amino acid, on voltage-gated Na+ currents

Huang, C-W., Hung, T. Y. & Wu, S-N., 2015 Feb 6, In : Neuroscience. 287, p. 125-136 12 p.

Research output: Contribution to journalArticle

Amino Acids
lacosamide
Neurons
Convulsants
Drug Interactions
4 Citations (Scopus)
HSP90 Heat-Shock Proteins
Pancreatic Ducts
Cell Line
Epithelial Cells
Fluids and Secretions
2014
11 Citations (Scopus)
Motor Neurons
Flavonoids
Potassium
linopirdine
flupirtine
3 Citations (Scopus)
Intermediate-Conductance Calcium-Activated Potassium Channels
Diphosphonates
Osteoclasts
Nitrogen
Sodium
4 Citations (Scopus)

Effects of midazolam on ion currents and membrane potential in differentiated motor neuron-like NSC-34 and NG108-15 cells

So, E. C., Wu, K. C., Kao, F. C. & Wu, S-N., 2014 Feb 5, In : European Journal of Pharmacology. 724, 1, p. 152-160 9 p.

Research output: Contribution to journalArticle

Midazolam
Motor Neurons
Membrane Potentials
Ions
Action Potentials
3 Citations (Scopus)

High effectiveness of triptolide, an active diterpenoid triepoxide, in suppressing Kir-channel currents from human glioma cells

Cheung So, E., Lo, Y. C., Chen, L. T., Kao, C. A. & Wu, S-N., 2014 Sep 5, In : European Journal of Pharmacology. 738, p. 332-341 10 p.

Research output: Contribution to journalArticle

Diterpenes
Glioma
Ions
Inwardly Rectifying Potassium Channel
triptolide
2 Citations (Scopus)

Stimulation of electroporation-induced inward currents in glioblastoma cell lines by the heat shock protein inhibitor AUY922

Chiang, N. J., Wu, S-N., Kao, C. A., Huang, Y. M. & Chen, L. T., 2014 Oct 1, In : Clinical and Experimental Pharmacology and Physiology. 41, 10, p. 830-837 8 p.

Research output: Contribution to journalArticle

Electroporation
Glioblastoma
Heat-Shock Proteins
Cell Line
tanespimycin
2013
2 Citations (Scopus)

Identification of minuscule inward currents as precursors to membrane electroporation-induced currents: Real-time prediction of pore appearance

So, E. C., Tsai, K. L., Wu, F. T., Hsu, M. C., Wu, K. C. & Wu, S-N., 2013 Jan 1, In : Cellular Physiology and Biochemistry. 32, 2, p. 402-416 15 p.

Research output: Contribution to journalArticle

Electroporation
Principal Component Analysis
Membranes
Carnitine
Isoflurane
7 Citations (Scopus)

Pregabalin Attenuates Excitotoxicity in Diabetes

Huang, C-W., Lai, M. C., Cheng, J. T., Tsai, J. J., Huang, C-C. & Wu, S-N., 2013 Jun 13, In : PloS one. 8, 6, e65154.

Research output: Contribution to journalArticle

seizures
Medical problems
diabetes
Rats
Seizures
17 Citations (Scopus)

The inhibition of inwardly rectifying K channels by memantine in macrophages and microglial cells

Tsai, K. L., Chang, H. F. & Wu, S-N., 2013 Jan 1, In : Cellular Physiology and Biochemistry. 31, 6, p. 938-951 14 p.

Research output: Contribution to journalArticle

Inwardly Rectifying Potassium Channel
Memantine
Macrophages
Patch-Clamp Techniques
Membranes
14 Citations (Scopus)
Diclofenac
Potassium Channels
Non-Steroidal Anti-Inflammatory Agents
Theoretical Models
Neurons
2012
77 Citations (Scopus)
Phosphatidylinositol 3-Kinase
Berberine
Motor Neurons
Heme Oxygenase-1
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one
24 Citations (Scopus)

Characterizing the effects of Eugenol on neuronal ionic currents and hyperexcitability

Huang, C-W., Chow, J. C., Tsai, J. J. & Wu, S-N., 2012 Jun 1, In : Psychopharmacology. 221, 4, p. 575-587 13 p.

Research output: Contribution to journalArticle

Eugenol
Seizures
Pilocarpine
Action Potentials
Temporal Lobe
5 Citations (Scopus)

Effects of ketamine and its metabolites on ion currents in differentiated hippocampal H19-7 neuronal cells and in HEK293T cells transfected with α-hslo subunit

Huang, M. H., Lin, K. H., Chen, S. J., Shen, A. Y., Wu, F. T. & Wu, S-N., 2012 Oct 1, In : NeuroToxicology. 33, 5, p. 1058-1066 9 p.

Research output: Contribution to journalArticle

Ketamine
Metabolites
Ions
Neurons
Calcium-Activated Potassium Channels
17 Citations (Scopus)

Electrophysiological characterization of sodium-activated potassium channels in NG108-15 and NSC-34 motor neuron-like cells

Wu, S-N., Yeh, C. C., Huang, H. C., So, E. C. & Lo, Y. C., 2012 Oct 1, In : Acta Physiologica. 206, 2, p. 120-134 15 p.

Research output: Contribution to journalArticle

Potassium Channels
Motor Neurons
Sodium
Riluzole
Tetrodotoxin
13 Citations (Scopus)

Evidence for inhibitory effects of flupirtine, a centrally acting analgesic, on delayed rectifier K + currents in motor neuron-like cells

Wu, S. N., Hsu, M. C., Liao, Y. K., Wu, F. T., Jong, Y. J. & Lo, Y. C., 2012 Aug 20, In : Evidence-based Complementary and Alternative Medicine. 2012, 148403.

Research output: Contribution to journalArticle

flupirtine
Motor Neurons
Analgesics
linopirdine
GABA Agents