• 2043 Citations
  • 28 h-Index
1988 …2019

Research output per year

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Research Output

2019

An Aptamer Based Sandwich Assay for Simultaneous Detection of Multiple Cardiovascular Biomarkers on A Multilayered Integrated Microfluidic System

Sinha, A., Gopinathan, P., Chung, Y. D., Shiesh, S. C. & Lee, G. B., 2019 Jun, 2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems and Eurosensors XXXIII, TRANSDUCERS 2019 and EUROSENSORS XXXIII. Institute of Electrical and Electronics Engineers Inc., p. 1075-1077 3 p. 8808551. (2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems and Eurosensors XXXIII, TRANSDUCERS 2019 and EUROSENSORS XXXIII).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

An integrated microfluidic system for on-chip enrichment and quantification of circulating extracellular vesicles from whole blood

Chen, Y. S., Ma, Y. D., Chen, C., Shiesh, S. C. & Lee, G. B., 2019 Jan 1, In : Lab on a Chip. 19, 19, p. 3305-3315 11 p.

Research output: Contribution to journalArticle

An integrated microfluidic system with field-effect-transistor sensor arrays for detecting multiple cardiovascular biomarkers from clinical samples

Sinha, A., Tai, T. Y., Li, K. H., Gopinathan, P., Chung, Y. D., Sarangadharan, I., Ma, H. P., Huang, P. C., Shiesh, S-C., Wang, Y. L. & Lee, G. B., 2019 Mar 15, In : Biosensors and Bioelectronics. 129, p. 155-163 9 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Design and Demonstration of Tunable Amplified Sensitivity of AlGaN/GaN High Electron Mobility Transistor (HEMT)-Based Biosensors in Human Serum

Tai, T. Y., Sinha, A., Sarangadharan, I., Pulikkathodi, A. K., Wang, S. L., Lee, G. Y., Chyi, J. I., Shiesh, S. C., Lee, G. B. & Wang, Y. L., 2019 May 7, In : Analytical chemistry. 91, 9, p. 5953-5960 8 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Optimization of an enzyme linked DNA aptamer assay for cardiac troponin i detection: Synchronous multiple sample analysis on an integrated microfluidic platform

Gopinathan, P., Sinha, A., Chung, Y. D., Shiesh, S. C. & Lee, G. B., 2019 Aug 21, In : Analyst. 144, 16, p. 4943-4951 9 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Simultaneous detection of multiple NT-proBNP clinical samples utilizing an aptamer-based sandwich assay on an integrated microfluidic system

Sinha, A., Gopinathan, P., Chung, Y. D., Shiesh, S. C. & Lee, G. B., 2019 Jan 1, In : Lab on a Chip. 19, 9, p. 1676-1685 10 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2018

A fibrinogen assay using specific aptamer on an integrated microfluidic chip

Chung, Y. D., Sinha, A., Gopinathan, P., Lin, H. Y., Shiesh, S. C. & Lee, G. B., 2018 Jan 1, 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018. Chemical and Biological Microsystems Society, p. 1882-1885 4 p. (22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018; vol. 4).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

An integrated microfluidic platform to perform uninterrupted SELEX cycles to screen affinity reagents specific to cardiovascular biomarkers

Sinha, A., Gopinathan, P., Chung, Y., Lin, H., Li, K., Ma, H., Huang, P., Shiesh, S. & Lee, G., 2018 Dec 1, In : Biosensors and Bioelectronics. 122, p. 104-112

Research output: Contribution to journalArticle

9 Citations (Scopus)

Aptamer-functionalized AlGaN/GaN high-electron-mobility transistor for rapid diagnosis of fibrinogen in human plasma

Tai, T. Y., Sinha, A., Sarangadharan, I., Pulikkathodi, A. K., Wang, S. L., Shiesh, S. C., Lee, G. B. & Wang, Y. L., 2018 Jan 1, In : Sensors and Materials. 30, 10, p. 2321-2331 11 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

High sensitivity cardiac troponin I detection in physiological environment using AlGaN/GaN High Electron Mobility Transistor (HEMT) Biosensors

Sarangadharan, I., Regmi, A., Chen, Y. W., Hsu, C. P., Chen, P. C., Chang, W. H., Lee, G. Y., Chyi, J. I., Shiesh, S. C., Lee, G. B. & Wang, Y. L., 2018 Feb 15, In : Biosensors and Bioelectronics. 100, p. 282-289 8 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)

Microfluidic platforms for rapid screening of cancer affinity reagents by using tissue samples

Hung, L. Y., Fu, C. Y., Wang, C. H., Chuang, Y. J., Tsai, Y. C., Lo, Y. L., Hsu, P. H., Chang, H. Y., Shiesh, S. C., Hsu, K. F. & Lee, G. B., 2018 Sep 1, In : Biomicrofluidics. 12, 5, 054108.

Research output: Contribution to journalArticle

5 Citations (Scopus)
2017

Beyond the Debye length in high ionic strength solution: Direct protein detection with field-effect transistors (FETs) in human serum

Chu, C. H., Sarangadharan, I., Regmi, A., Chen, Y. W., Hsu, C. P., Chang, W. H., Lee, G. Y., Chyi, J. I., Chen, C. C., Shiesh, S. C., Lee, G. B. & Wang, Y. L., 2017 Dec 1, In : Scientific reports. 7, 1, 5256.

Research output: Contribution to journalArticle

67 Citations (Scopus)

Bile acid profiles in neonatal intrahepatic cholestasis caused by citrin deficiency

Yang, C. H., Chen, C. Y., Chou, Y. Y., Chiu, H. C., Tsai, W. L. & Shiesh, S. C., 2017 Dec, In : Clinica Chimica Acta. 475, p. 28-35 8 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Detection of C-reactive protein on an integrated microfluidic system by utilizing field-effect transistors and aptamers

Kao, W. C., Chen, Y. W., Chu, C. H., Chang, W. H., Shiesh, S. C., Wang, Y. L. & Lee, G. B., 2017 Jul 1, In : Biomicrofluidics. 11, 4, 044105.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Direct detection of fibrinogen in human plasma using electric-double-layer gated AlGaN/GaN high electron mobility transistors

Regmi, A., Sarangadharan, I., Chen, Y. W., Hsu, C. P., Lee, G. Y., Chyi, J. I., Shiesh, S. C., Lee, G. B. & Wang, Y. L., 2017 Aug 21, In : Applied Physics Letters. 111, 8, 082106.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Field-effect transistor-based biosensors and a portable device for personal healthcare

Chen, P. C., Chen, Y. W., Sarangadharan, I., Hsu, C. P., Chen, C. C., Shiesh, S-C., Lee, G. B. & Wang, Y. L., 2017 Jan 1, In : ECS Journal of Solid State Science and Technology. 6, 7, p. Q71-Q76

Research output: Contribution to journalArticle

11 Citations (Scopus)

Microfluidic platform capable of performing automatic tissue slide-based selex and phage display for rapid screening of affinity reagents specific to ovarian cancer

Hung, L. Y., Fu, C. Y., Wang, C. H., Chuang, Y. J., Tsai, Y. C., Lo, Y. L., Lee, W. B., Shiesh, S. C., Chang, H. Y., Hsu, K. F. & Lee, G. B., 2017 Jul 26, TRANSDUCERS 2017 - 19th International Conference on Solid-State Sensors, Actuators and Microsystems. Institute of Electrical and Electronics Engineers Inc., p. 568-571 4 p. 7994112. (TRANSDUCERS 2017 - 19th International Conference on Solid-State Sensors, Actuators and Microsystems).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)
2016

Integrated microfluidic systems for screening of aptamers specific to cardiovascular biomarkers

Sinha, A., Chung, Y. D., Gopinathan, P., Hung, L. Y., Yang, C. H., Shiesh, S. C. & Lee, G. B., 2016 Jan 1, 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016. Chemical and Biological Microsystems Society, p. 67-68 2 p. (20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

On-chip, aptamer-based sandwich assay for detection of glycated hemoglobins via magnetic beads

Li, J., Chang, K. W., Wang, C. H., Yang, C. H., Shiesh, S. C. & Lee, G. B., 2016 May 15, In : Biosensors and Bioelectronics. 79, p. 887-893 7 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Urine microchip sensing system

Luo, C. H., Syu, M. J., Shiesh, S. C., Lai, S. C., Ma, W. J., Juan, Y. H. & Juang, W. H., 2016 Jan 1, Smart Sensors and Systems: Innovations for Medical, Environmental, and IoT Applications. Springer International Publishing, p. 359-384 26 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2015

An integrated microfluidic system for measurement of glycated hemoglobin Levels by using an aptamer-antibody assay on magnetic beads

Chang, K. W., Li, J., Yang, C. H., Shiesh, S. C. & Lee, G. B., 2015 Jun 5, In : Biosensors and Bioelectronics. 68, p. 397-403 7 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Measurement of glycated hemoglobin levels using an integrated microfluidic system

Wu, C. C., Lin, H. I., Chang, K. W., Mai, J. D., Shiesh, S-C. & Lee, G. B., 2015 Jan 1, In : Microfluidics and Nanofluidics. 18, 4, p. 613-621 9 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Selection of aptamers specific for glycated hemoglobin and total hemoglobin using on-chip SELEX

Lin, H. I., Wu, C. C., Yang, C. H., Chang, K. W., Lee, G. B. & Shiesh, S. C., 2015 Jan 21, In : Lab on a Chip. 15, 2, p. 486-494 9 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)
2014

Apolipoprotein C-III is an amyloid-β-binding protein and an early marker for Alzheimer's disease

Shih, Y. H., Tsai, K. J., Lee, C. W., Shiesh, S. C., Chen, W. T., Pai, M. C. & Kuo, Y. M., 2014 Jan 1, In : Journal of Alzheimer's disease : JAD. 41, 3, p. 855-865 11 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Measurement of glycated hemoglobin using an aptamer/antibody assay on an integrated microfluidic system

Chang, K. W., Li, J. L., Yang, C. H., Shiesh, S. C. & Lee, G. B., 2014 Sep 23, 9th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE-NEMS 2014. Institute of Electrical and Electronics Engineers Inc., p. 647-650 4 p. 6908895. (9th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE-NEMS 2014).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Citations (Scopus)

On-Chip HbA1C detection utlizing a compact surface pla-smon grating sensor integrated on a microfldic system

Chang, K. W., Chou, H. T., Yang, C. H., Shiesh, S. C., Lee, M. C. & Lee, G. B., 2014 Jan 1, 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014. Chemical and Biological Microsystems Society, p. 2076-2078 3 p. (18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Rapid and sensitive measurement of glycated hemoglobin for diabetes monitoring by using a two-aptamer assay on an integrated microfluidic system

Li, J., Chang, K. W., Yang, C. H., Shiesh, S-C. & Lee, G. B., 2014, 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014. Chemical and Biological Microsystems Society, p. 1951-1953 3 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)
2013

An automatic microfluidic system for rapid screening of cancer stem-like cell-specific aptamers

Weng, C. H., Hsieh, I. S., Hung, L. Y., Lin, H. I., Shiesh, S. C., Chen, Y. L. & Lee, G. B., 2013 Jan 1, In : Microfluidics and Nanofluidics. 14, 3-4, p. 753-765 13 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)

An integrated microfluidic system for rapid HbA1c measurement

Wu, C. C., Chang, K. W., Lin, H. I., Shiesh, S-C. & Lee, G. B., 2013 Jan 1, 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013. Chemical and Biological Microsystems Society, p. 684-686 3 p. (17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013; vol. 1).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Attenuation of argininosuccinate lyase inhibits cancer growth via cyclin A2 and nitric oxide

Huang, H. L., Hsu, H. P., Shieh, S. C., Chang, Y. S., Chen, W. C., Cho, C. Y., Teng, C. F., Su, I. J., Hung, W. C. & Lai, M. D., 2013 Nov, In : Molecular Cancer Therapeutics. 12, 11, p. 2505-2516 12 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Carbon monoxide may enhance bile secretion by increasing glutathione excretion and Mrp2 expression in rats

Chen, C. Y., Kao, C. Y., Lin, P. J. & Shiesh, S. C., 2013 May 1, In : Journal of the Chinese Medical Association. 76, 5, p. 258-264 7 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Glycine ameliorates liver injury and vitamin D deficiency induced by bile duct ligation

Chen, C-Y., Wang, B. T., Wu, Z. C., Yu, W. T., Lin, P. J., Tsai, W. L. & Shiesh, S-C., 2013 May 1, In : Clinica Chimica Acta. 420, p. 150-154 5 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Increased aortic stiffness and attenuated lysyl oxidase activity in obesity

Chen, J. Y., Tsai, P. J., Tai, H. C., Tsai, R. L., Chang, Y. T., Wang, M. C., Chiou, Y. W., Yeh, M. L., Tang, M. J., Lam, C. F., Shiesh, S. C., Li, Y. H., Tsai, W. C., Chou, C. H., Lin, L. J., Wu, H. L. & Tsai, Y. S., 2013 Apr 1, In : Arteriosclerosis, thrombosis, and vascular biology. 33, 4, p. 839-846 8 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)

The Asian project for collaborative derivation of reference intervals: (1) strategy and major results of standardized analytes

Ichihara, K., Ceriotti, F., Tam, T. H., Sueyoshi, S., Poon, P. M. K., Thong, M. L., Higashiuesato, Y., Wang, X., Kataoka, H., Matsubara, A., Shiesh, S. C., Muliaty, D., Kim, J. H., Watanabe, M., Lam, C. W. K., Siekmann, L., Lopez, J. B. & Panteghini, M., 2013 Jul 1, In : Clinical Chemistry and Laboratory Medicine. 51, 7, p. 1429-1442 14 p.

Research output: Contribution to journalArticle

41 Citations (Scopus)
2012

An automatic microfluidic system that continuously performs the systematic evolution of ligands by exponential enrichment

Chen, Y. H., Lin, H. I., Huang, C. J., Shiesh, S. C. & Lee, G. B., 2012 Dec 1, In : Microfluidics and Nanofluidics. 13, 6, p. 929-939 11 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

An integrated microfluidic system for rapid screening of alpha-fetoprotein-specific aptamers

Huang, C. J., Lin, H. I., Shiesh, S. C. & Lee, G. B., 2012 May 15, In : Biosensors and Bioelectronics. 35, 1, p. 50-55 6 p.

Research output: Contribution to journalArticle

63 Citations (Scopus)

A rapid screening for hemoglobin-specific aptamers by using a continuous microfluidic system

Wu, C. C., Lin, H. I., Weng, C. H., Shiesh, S. C. & Lee, G. B., 2012 Jan 1, Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012. Chemical and Biological Microsystems Society, p. 353-355 3 p. (Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Citations (Scopus)

Rapid measurement of AFP using AFP-specific aptamer on a microfluidic chip

Huang, C. J., Lin, H. I., Shiesh, S. C. & Lee, G. B., 2012 May 7, 2012 IEEE 25th International Conference on Micro Electro Mechanical Systems, MEMS 2012. p. 874-877 4 p. 6170325. (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)
2011

An integrated microfluidic system for automating on-chip selex process to screen tumor cell-specific aptamers

Weng, C. H., Hung, L. Y., Lin, H. I., Hsieh, I. S., Shiesh, S. C., Chen, Y. L. & Lee, G. B., 2011, 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011. Vol. 3. p. 2086-2088 3 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

An integrated microfluidic system for fast, automatic detection of C-reactive protein

Lee, W. B., Chen, Y. H., Lin, H. I., Shiesh, S. C. & Lee, G. B., 2011 Oct 20, In : Sensors and Actuators, B: Chemical. 157, 2, p. 710-721 12 p.

Research output: Contribution to journalArticle

56 Citations (Scopus)

An integrated microfluidic system for rapid screening of alpha-fetoprotein aptamers

Huang, C. J., Lin, H. I., Shiesh, S-C. & Lee, G. B., 2011 Apr 13, 2011 IEEE 24th International Conference on Micro Electro Mechanical Systems, MEMS 2011. p. 185-188 4 p. 5734392. (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

High resolution melting analysis for the detection of SLC25A13 gene mutations in Taiwan

Lin, J. T., Hsiao, K. J., Chen, C. Y., Wu, C. C., Lin, S. J., Chou, Y. Y. & Shiesh, S. C., 2011 Feb 20, In : Clinica Chimica Acta. 412, 5-6, p. 460-465 6 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

The value of serum ischemia-modified albumin for assessing liver function in patients with chronic liver disease

Chen, C. Y., Tsai, W. L., Lin, P. J. & Shiesh, S. C., 2011 Nov 1, In : Clinical Chemistry and Laboratory Medicine. 49, 11, p. 1817-1821 5 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)
2010

A magnetic-bead based microfluidic system for automatic C-reactive protein detection

Lee, W. B., Lin, H. I., Shiesh, S-C. & Lee, G. B., 2010 Jul 12, Proceedings of the ASME Micro/Nanoscale Heat and Mass Transfer International Conference 2009, MNHMT2009. p. 257-260 4 p. (Proceedings of the ASME Micro/Nanoscale Heat and Mass Transfer International Conference 2009, MNHMT2009; vol. 1).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

A microfluidic system integrated with optical detection devices for automatic detection of C-reactive protein

Lee, W. B., Chen, Y. H., Lin, H. I., Huang, C. J., Shiesh, S. C. & Lee, G. B., 2010 Jun 1, MEMS 2010 - The 23rd IEEE International Conference on Micro Electro Mechanical Systems, Technical Digest. p. 979-982 4 p. 5442372. (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Integrated microfluidic system for rapid screening of CRP aptamers utilizing systematic evolution of ligands by exponential enrichment (SELEX)

Huang, C. J., Lin, H. I., Shiesh, S-C. & Lee, G. B., 2010 Mar 15, In : Biosensors and Bioelectronics. 25, 7, p. 1761-1766 6 p.

Research output: Contribution to journalArticle

94 Citations (Scopus)

Low serum testosterone and frailty in older men and women

Wu, I. C., Lin, X. Z., Liu, P. F., Tsai, W. L. & Shiesh, S. C., 2010 Dec 1, In : Maturitas. 67, 4, p. 348-352 5 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)
2009

An integrated microfluidic system for C-reactive protein measurement

Yang, Y. N., Lin, H. I., Wang, J. H., Shiesh, S. C. & Lee, G. B., 2009 Jun 15, In : Biosensors and Bioelectronics. 24, 10, p. 3091-3096 6 p.

Research output: Contribution to journalArticle

57 Citations (Scopus)

High oxidative stress is correlated with frailty in elderly Chinese

Wu, I. C., Shiesh, S. C., Kuo, P. H. & Lin, X. Z., 2009 Sep 1, In : Journal of the American Geriatrics Society. 57, 9, p. 1666-1671 6 p.

Research output: Contribution to journalArticle

71 Citations (Scopus)

Integrated microfluidic system for rapid selection of CRP aptamers utilizing systematic evolution of ligands by exponentail enrichment

Huang, C. J., Lin, H. I., Shiesh, S-C. & Lee, G. B., 2009 Jan 1, Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Chemical and Biological Microsystems Society, p. 150-152 3 p. (Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)