• 1918 Citations
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1988 …2019
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Research Output 1988 2019

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Article
2019
1 Citation (Scopus)

An integrated microfluidic system with field-effect-transistor sensor arrays for detecting multiple cardiovascular biomarkers from clinical samples

Sinha, A., Tai, T. Y., Li, K. H., Gopinathan, P., Chung, Y. D., Sarangadharan, I., Ma, H. P., Huang, P. C., Shiesh, S-C., Wang, Y. L. & Lee, G. B., 2019 Mar 15, In : Biosensors and Bioelectronics. 129, p. 155-163 9 p.

Research output: Contribution to journalArticle

Microfluidics
Sensor arrays
Biomarkers
Field effect transistors
Cardiovascular Diseases
1 Citation (Scopus)

Design and Demonstration of Tunable Amplified Sensitivity of AlGaN/GaN High Electron Mobility Transistor (HEMT)-Based Biosensors in Human Serum

Tai, T. Y., Sinha, A., Sarangadharan, I., Pulikkathodi, A. K., Wang, S. L., Lee, G. Y., Chyi, J. I., Shiesh, S-C., Lee, G. B. & Wang, Y. L., 2019 May 7, In : Analytical chemistry. 91, 9, p. 5953-5960 8 p.

Research output: Contribution to journalArticle

High electron mobility transistors
Biosensors
Demonstrations
Sensors
Proteins
1 Citation (Scopus)

Optimization of an enzyme linked DNA aptamer assay for cardiac troponin i detection: Synchronous multiple sample analysis on an integrated microfluidic platform

Gopinathan, P., Sinha, A., Chung, Y. D., Shiesh, S-C. & Lee, G. B., 2019 Aug 21, In : Analyst. 144, 16, p. 4943-4951 9 p.

Research output: Contribution to journalArticle

Nucleotide Aptamers
Troponin
Troponin I
Microfluidics
Assays

Simultaneous detection of multiple NT-proBNP clinical samples utilizing an aptamer-based sandwich assay on an integrated microfluidic system

Sinha, A., Gopinathan, P., Chung, Y. D., Shiesh, S-C. & Lee, G. B., 2019 Jan 1, In : Lab on a Chip. 19, 9, p. 1676-1685 10 p.

Research output: Contribution to journalArticle

Microfluidics
Assays
Heart Failure
Brain Natriuretic Peptide
Biomarkers
2018
9 Citations (Scopus)

An integrated microfluidic platform to perform uninterrupted SELEX cycles to screen affinity reagents specific to cardiovascular biomarkers

Sinha, A., Gopinathan, P., Chung, Y., Lin, H., Li, K., Ma, H., Huang, P., Shiesh, S. & Lee, G., 2018 Dec 1, In : Biosensors and Bioelectronics. 122, p. 104-112

Research output: Contribution to journalArticle

1 Citation (Scopus)

Aptamer-functionalized AlGaN/GaN high-electron-mobility transistor for rapid diagnosis of fibrinogen in human plasma

Tai, T. Y., Sinha, A., Sarangadharan, I., Pulikkathodi, A. K., Wang, S. L., Shiesh, S-C., Lee, G. B. & Wang, Y. L., 2018 Jan 1, In : Sensors and Materials. 30, 10, p. 2321-2331 11 p.

Research output: Contribution to journalArticle

Plasma (human)
fibrinogen
High electron mobility transistors
high electron mobility transistors
bioinstrumentation
31 Citations (Scopus)

High sensitivity cardiac troponin I detection in physiological environment using AlGaN/GaN High Electron Mobility Transistor (HEMT) Biosensors

Sarangadharan, I., Regmi, A., Chen, Y. W., Hsu, C. P., Chen, P. C., Chang, W. H., Lee, G. Y., Chyi, J. I., Shiesh, S-C., Lee, G. B. & Wang, Y. L., 2018 Feb 15, In : Biosensors and Bioelectronics. 100, p. 282-289 8 p.

Research output: Contribution to journalArticle

Troponin I
Biosensing Techniques
High electron mobility transistors
Biosensors
Electrons
1 Citation (Scopus)

Microfluidic platforms for rapid screening of cancer affinity reagents by using tissue samples

Hung, L. Y., Fu, C. Y., Wang, C. H., Chuang, Y. J., Tsai, Y. C., Lo, Y. L., Hsu, P. H., Chang, H. Y., Shiesh, S-C., Hsu, K-F. & Lee, G. B., 2018 Sep 1, In : Biomicrofluidics. 12, 5, 054108.

Research output: Contribution to journalArticle

Microfluidics
Early Detection of Cancer
Ovarian Neoplasms
reagents
affinity
2017
49 Citations (Scopus)

Beyond the Debye length in high ionic strength solution: Direct protein detection with field-effect transistors (FETs) in human serum

Chu, C. H., Sarangadharan, I., Regmi, A., Chen, Y. W., Hsu, C. P., Chang, W. H., Lee, G. Y., Chyi, J. I., Chen, C. C., Shiesh, S-C., Lee, G. B. & Wang, Y. L., 2017 Dec 1, In : Scientific reports. 7, 1, 5256.

Research output: Contribution to journalArticle

Field effect transistors
Ionic strength
Proteins
Sensors
High electron mobility transistors
1 Citation (Scopus)

Bile acid profiles in neonatal intrahepatic cholestasis caused by citrin deficiency

Yang, C. H., Chen, C-Y., Chou, Y-Y., Chiu, H-C., Tsai, W. L. & Shiesh, S-C., 2017 Dec 1, In : Clinica Chimica Acta. 475, p. 28-35 8 p.

Research output: Contribution to journalArticle

Bile Acids and Salts
Plasmas
Neonatal-onset citrullinemia type 2
citrin
Citrullinemia
5 Citations (Scopus)

Detection of C-reactive protein on an integrated microfluidic system by utilizing field-effect transistors and aptamers

Kao, W. C., Chen, Y. W., Chu, C. H., Chang, W. H., Shiesh, S-C., Wang, Y. L. & Lee, G. B., 2017 Jul 1, In : Biomicrofluidics. 11, 4, 044105.

Research output: Contribution to journalArticle

Microfluidics
Field effect transistors
C-Reactive Protein
field effect transistors
proteins
6 Citations (Scopus)

Direct detection of fibrinogen in human plasma using electric-double-layer gated AlGaN/GaN high electron mobility transistors

Regmi, A., Sarangadharan, I., Chen, Y. W., Hsu, C. P., Lee, G. Y., Chyi, J. I., Shiesh, S-C., Lee, G. B. & Wang, Y. L., 2017 Aug 21, In : Applied Physics Letters. 111, 8, 082106.

Research output: Contribution to journalArticle

fibrinogen
high electron mobility transistors
sensors
proteins
blood plasma
8 Citations (Scopus)

Field-effect transistor-based biosensors and a portable device for personal healthcare

Chen, P. C., Chen, Y. W., Sarangadharan, I., Hsu, C. P., Chen, C. C., Shiesh, S-C., Lee, G. B. & Wang, Y. L., 2017 Jan 1, In : ECS Journal of Solid State Science and Technology. 6, 7, p. Q71-Q76

Research output: Contribution to journalArticle

Field effect transistors
Biosensors
C-Reactive Protein
Proteins
High electron mobility transistors
2016
26 Citations (Scopus)

On-chip, aptamer-based sandwich assay for detection of glycated hemoglobins via magnetic beads

Li, J., Chang, K. W., Wang, C. H., Yang, C. H., Shiesh, S-C. & Lee, G. B., 2016 May 15, In : Biosensors and Bioelectronics. 79, p. 887-893 7 p.

Research output: Contribution to journalArticle

Microfluidics
Hemoglobin
Glycosylated Hemoglobin A
Assays
Medical problems
2015
25 Citations (Scopus)

An integrated microfluidic system for measurement of glycated hemoglobin Levels by using an aptamer-antibody assay on magnetic beads

Chang, K. W., Li, J., Yang, C. H., Shiesh, S-C. & Lee, G. B., 2015 Jun 5, In : Biosensors and Bioelectronics. 68, p. 397-403 7 p.

Research output: Contribution to journalArticle

Microfluidics
Hemoglobin
Glycosylated Hemoglobin A
Antibodies
Assays
6 Citations (Scopus)

Measurement of glycated hemoglobin levels using an integrated microfluidic system

Wu, C. C., Lin, H. I., Chang, K. W., Mai, J. D., Shiesh, S-C. & Lee, G. B., 2015 Jan 1, In : Microfluidics and Nanofluidics. 18, 4, p. 613-621 9 p.

Research output: Contribution to journalArticle

Hemoglobin
Glycosylated Hemoglobin A
hemoglobin
Microfluidics
diabetes mellitus
20 Citations (Scopus)

Selection of aptamers specific for glycated hemoglobin and total hemoglobin using on-chip SELEX

Lin, H. I., Wu, C. C., Yang, C. H., Chang, K. W., Lee, G. B. & Shiesh, S-C., 2015 Jan 21, In : Lab on a Chip. 15, 2, p. 486-494 9 p.

Research output: Contribution to journalArticle

SELEX Aptamer Technique
Hemoglobin
Glycosylated Hemoglobin A
Hemoglobins
Ligands
2014
21 Citations (Scopus)

Apolipoprotein C-III is an amyloid-β-binding protein and an early marker for Alzheimer's disease

Shih, Y. H., Tsai, K-J., Lee, C. W., Shiesh, S-C., Chen, W. T., Pai, M-C. & Kuo, Y-M., 2014 Jan 1, In : Journal of Alzheimer's disease : JAD. 41, 3, p. 855-865 11 p.

Research output: Contribution to journalArticle

Apolipoprotein C-III
Amyloidogenic Proteins
Carrier Proteins
Alzheimer Disease
Apolipoprotein A-I
2013
31 Citations (Scopus)

An automatic microfluidic system for rapid screening of cancer stem-like cell-specific aptamers

Weng, C. H., Hsieh, I. S., Hung, L. Y., Lin, H. I., Shiesh, S-C., Chen, Y-L. & Lee, G. B., 2013 Jan 1, In : Microfluidics and Nanofluidics. 14, 3-4, p. 753-765 13 p.

Research output: Contribution to journalArticle

stem cells
Microfluidics
Screening
screening
cancer
16 Citations (Scopus)

Attenuation of argininosuccinate lyase inhibits cancer growth via cyclin A2 and nitric oxide

Huang, H. L., Hsu, H-P., Shiesh, S-C., Chang, Y. S., Chen, W. C., Cho, C. Y., Teng, C. F., Su, I. J., Hung, W. C. & Lai, M-D., 2013 Jan 1, In : Molecular Cancer Therapeutics. 12, 11, p. 2505-2516 12 p.

Research output: Contribution to journalArticle

Cyclin A2
Argininosuccinate Lyase
Nitric Oxide
Growth
Small Interfering RNA
5 Citations (Scopus)

Carbon monoxide may enhance bile secretion by increasing glutathione excretion and Mrp2 expression in rats

Chen, C-Y., Kao, C. Y., Lin, P. J. & Shiesh, S-C., 2013 May 1, In : Journal of the Chinese Medical Association. 76, 5, p. 258-264 7 p.

Research output: Contribution to journalArticle

Methylene Chloride
Carbon Monoxide
Bile
Glutathione
Nitric Oxide Synthase
11 Citations (Scopus)

Glycine ameliorates liver injury and vitamin D deficiency induced by bile duct ligation

Chen, C-Y., Wang, B. T., Wu, Z. C., Yu, W. T., Lin, P. J., Tsai, W. L. & Shiesh, S-C., 2013 May 1, In : Clinica Chimica Acta. 420, p. 150-154 5 p.

Research output: Contribution to journalArticle

Vitamin D Deficiency
Bile Ducts
Vitamin D
Liver
Ducts
37 Citations (Scopus)

Increased aortic stiffness and attenuated lysyl oxidase activity in obesity

Chen, Z-Y., Tsai, P-J., Tai, H. C., Tsai, R. L., Chang, Y-T., Wang, M. C., Chiou, Y. W., Yeh, M-L., Tang, M-J., Lam, C. F., Shiesh, S-C., Li, Y-H., Tsai, W-C., Chou, C. H., Lin, L. J., Wu, H-L. & Tsai, Y-S., 2013 Apr 1, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 33, 4, p. 839-846 8 p.

Research output: Contribution to journalArticle

Protein-Lysine 6-Oxidase
Vascular Stiffness
Obesity
Elastin
Aorta
38 Citations (Scopus)

The Asian project for collaborative derivation of reference intervals: (1) strategy and major results of standardized analytes

Ichihara, K., Ceriotti, F., Tam, T. H., Sueyoshi, S., Poon, P. M. K., Thong, M. L., Higashiuesato, Y., Wang, X., Kataoka, H., Matsubara, A., Shiesh, S-C., Muliaty, D., Kim, J. H., Watanabe, M., Lam, C. W. K., Siekmann, L., Lopez, J. B. & Panteghini, M., 2013 Jul 1, In : Clinical Chemistry and Laboratory Medicine. 51, 7, p. 1429-1442 14 p.

Research output: Contribution to journalArticle

Clinical laboratories
Analysis of variance (ANOVA)
HDL Cholesterol
Japan
Hormones
2012
6 Citations (Scopus)

An automatic microfluidic system that continuously performs the systematic evolution of ligands by exponential enrichment

Chen, Y. H., Lin, H. I., Huang, C. J., Shiesh, S-C. & Lee, G. B., 2012 Dec 1, In : Microfluidics and Nanofluidics. 13, 6, p. 929-939 11 p.

Research output: Contribution to journalArticle

Microfluidics
Screening
DNA
screening
deoxyribonucleic acid
58 Citations (Scopus)

An integrated microfluidic system for rapid screening of alpha-fetoprotein-specific aptamers

Huang, C. J., Lin, H. I., Shiesh, S-C. & Lee, G. B., 2012 May 15, In : Biosensors and Bioelectronics. 35, 1, p. 50-55 6 p.

Research output: Contribution to journalArticle

SELEX Aptamer Technique
Microfluidics
alpha-Fetoproteins
Screening
Ligands
2011
53 Citations (Scopus)

An integrated microfluidic system for fast, automatic detection of C-reactive protein

Lee, W. B., Chen, Y. H., Lin, H. I., Shiesh, S-C. & Lee, G. B., 2011 Oct 20, In : Sensors and Actuators, B: Chemical. 157, 2, p. 710-721 12 p.

Research output: Contribution to journalArticle

Microfluidics
C-Reactive Protein
proteins
Proteins
Chemiluminescence
11 Citations (Scopus)

High resolution melting analysis for the detection of SLC25A13 gene mutations in Taiwan

Lin, J. T., Hsiao, K. J., Chen, C-Y., Wu, C. C., Lin, S. J., Chou, Y-Y. & Shiesh, S-C., 2011 Feb 20, In : Clinica Chimica Acta. 412, 5-6, p. 460-465 6 p.

Research output: Contribution to journalArticle

Taiwan
Freezing
Melting
Genes
Mutation
26 Citations (Scopus)

The value of serum ischemia-modified albumin for assessing liver function in patients with chronic liver disease

Chen, C-Y., Tsai, W. L., Lin, P. J. & Shiesh, S-C., 2011 Nov 1, In : Clinical Chemistry and Laboratory Medicine. 49, 11, p. 1817-1821 5 p.

Research output: Contribution to journalArticle

Serum Albumin
Liver
Liver Diseases
Chronic Disease
Albumins
2010
89 Citations (Scopus)

Integrated microfluidic system for rapid screening of CRP aptamers utilizing systematic evolution of ligands by exponential enrichment (SELEX)

Huang, C. J., Lin, H. I., Shiesh, S-C. & Lee, G. B., 2010 Mar 15, In : Biosensors and Bioelectronics. 25, 7, p. 1761-1766 6 p.

Research output: Contribution to journalArticle

SELEX Aptamer Technique
Microfluidics
C-Reactive Protein
Screening
Ligands
27 Citations (Scopus)

Low serum testosterone and frailty in older men and women

Wu, I. C., Lin, X-Z., Liu, P. F., Tsai, W. L. & Shiesh, S-C., 2010 Dec 1, In : Maturitas. 67, 4, p. 348-352 5 p.

Research output: Contribution to journalArticle

Testosterone
Serum
Odds Ratio
Confidence Intervals
Hand Strength
2009
57 Citations (Scopus)

An integrated microfluidic system for C-reactive protein measurement

Yang, Y. N., Lin, H. I., Wang, J. H., Shiesh, S-C. & Lee, G. B., 2009 Jun 15, In : Biosensors and Bioelectronics. 24, 10, p. 3091-3096 6 p.

Research output: Contribution to journalArticle

Microfluidics
C-Reactive Protein
Proteins
Nucleotide Aptamers
Chemiluminescence
63 Citations (Scopus)

High oxidative stress is correlated with frailty in elderly Chinese

Wu, I. C., Shiesh, S-C., Kuo, P. H. & Lin, X-Z., 2009 Sep 1, In : Journal of the American Geriatrics Society. 57, 9, p. 1666-1671 6 p.

Research output: Contribution to journalArticle

Oxidative Stress
Waist-Hip Ratio
C-Reactive Protein
Serum
Serum Albumin
5 Citations (Scopus)

Proficiency testing of Hb A1c: A 4-year experience in Taiwan and the Asian Pacific region

Shiesh, S-C., Wiedmeyer, H. M., Kao, J. T., Vasikaran, S. D. & Lopez, J. B., 2009 Oct 1, In : Clinical Chemistry. 55, 10, p. 1876-1880 5 p.

Research output: Contribution to journalArticle

Taiwan
Testing
Uncertainty
Hemoglobins
Diabetes Complications
2008
16 Citations (Scopus)

Diagnostic role of biliary pancreatic elastase for cholangiocarcinoma in patients with cholestasis

Chen, C-Y., Tsai, W. L., Wu, H. C., Syu, M-J., Wu, C. C. & Shiesh, S-C., 2008 Apr 1, In : Clinica Chimica Acta. 390, 1-2, p. 82-89 8 p.

Research output: Contribution to journalArticle

Cholangiocarcinoma
Pancreatic Elastase
Cholestasis
Bile
Biomarkers
4 Citations (Scopus)

Streptococcal pyrogenic exotoxin B cleaves human S-adenosylhomocysteine hydrolase and induces hypermethioninemia

Hsu, J. F., Chuang, W-J., Shiesh, S-C., Lin, Y-S., Liu, C-C., Wang, C. C., Fu, T-F., Tsai, J. H., Tsai, W. L., Huang, Y. J., Hsieh, Y. H., Wu, J. J., Lin, M. T. & Huang, W-Y., 2008 Aug 1, In : Journal of Infectious Diseases. 198, 3, p. 367-374 8 p.

Research output: Contribution to journalArticle

Adenosylhomocysteinase
Cysteine Proteases
Impetigo
Myositis
Pharyngitis
2006
128 Citations (Scopus)
Macrophage Migration-Inhibitory Factors
Severe Dengue
Dengue
Serum
Interleukin-10
15 Citations (Scopus)

Determination of C-reactive protein with an ultra-sensitivity immunochemiluminometric assay

Shiesh, S-C., Chou, T. C., Lin, X-Z. & Kao, P. C., 2006 Apr 20, In : Journal of Immunological Methods. 311, 1-2, p. 87-95 9 p.

Research output: Contribution to journalArticle

C-Reactive Protein
Blood Proteins
Acute-Phase Proteins
Polystyrenes
Latex
24 Citations (Scopus)

Ionic effect on the binding of bilirubin to the imprinted poly(methacrylic acid-co-ethylene glycol dimethylacrylate)

Syu, M-J., Nian, Y. M., Chang, Y. S., Lin, X-Z., Shiesh, S-C. & Chou, T. C., 2006 Jul 28, In : Journal of Chromatography A. 1122, 1-2, p. 54-62 9 p.

Research output: Contribution to journalArticle

Ethylene Glycol
Bilirubin
ethylenediamine
Polymers
Bile
79 Citations (Scopus)

Serum total antioxidant capacity reflects severity of illness in patients with severe sepsis

Chuang, C-C., Shiesh, S-C., Chi, C-H., Tu, Y-F., Hor, L. I., Shieh, C-C. & Chen, M. F., 2006 Feb 20, In : Critical Care. 10, 1, R36.

Research output: Contribution to journalArticle

Sepsis
Antioxidants
Serum
APACHE
Uric Acid
2005
7 Citations (Scopus)
Amylases
Intestines
Pancreas
Gallstones
Bile
2004
76 Citations (Scopus)

Amperometric detection of morphine at a Prussian blue-modified indium tin oxide electrode

Ho, K. C., Chen, C. Y., Hsu, H. C., Chen, L. C., Shiesh, S-C. & Lin, X-Z., 2004 Jul 30, In : Biosensors and Bioelectronics. 20, 1, p. 3-8 6 p.

Research output: Contribution to journalArticle

Tin oxides
Indium
Morphine
Electrodes
Thin films
58 Citations (Scopus)
Peptide Nucleic Acids
Polymorphism
Constriction
Bile
Restriction Fragment Length Polymorphisms
2003
11 Citations (Scopus)

Clinical application of 20 MHz endosonography and anti-Helicobacter pylori immunoblots to predict regression of low-grade gastric MALtoma by H. pylori eradication

Sheu, B-S., Shiesh, S-C., Wang, J. T., Yang, H. B., Lin, S. T. & Wu, J. J., 2003 Apr 12, In : Helicobacter. 8, 1, p. 36-45 10 p.

Research output: Contribution to journalArticle

Endosonography
Helicobacter pylori
Stomach
Serum
Immunoglobulin Heavy Chain Genes
13 Citations (Scopus)

The value of biliary fibronectin for diagnosis of cholangiocarcinoma

Chen, C-Y., Lin, X-Z., Tsao, H. C. & Shiesh, S-C., 2003 Jul, In : Hepato-Gastroenterology. 50, 52, p. 924-927 4 p.

Research output: Contribution to journalArticle

Cholangiocarcinoma
Fibronectins
Gallstones
Bile
Biliary Tract Neoplasms
2002
67 Citations (Scopus)
Cholangiocarcinoma
Cholangitis
Cholestasis
Tumor Biomarkers
Drainage
19 Citations (Scopus)

Total antioxidant capacity and malondialdehyde in acute abdominal pain

Chi, C-H., Shiesh, S-C. & Lin, X-Z., 2002 Jan 1, In : American Journal of Emergency Medicine. 20, 2, p. 79-82 4 p.

Research output: Contribution to journalArticle

Acute Pain
Malondialdehyde
Abdominal Pain
Antioxidants
Oxidative Stress
2001
40 Citations (Scopus)
Oncogene Proteins
Bile
Cholangiocarcinoma
Intercellular Signaling Peptides and Proteins
Fibrosis
7 Citations (Scopus)

Protective effect of melatonin on renal injury of rats induced by bile duct ligation

Chen, C-Y., Shiesh, S-C., Tsao, H. C., Chen, F. F. & Lin, X-Z., 2001 Jan 1, In : Digestive Diseases and Sciences. 46, 4, p. 927-931 5 p.

Research output: Contribution to journalArticle

Melatonin
Bile Ducts
Ligation
Kidney
Gentamicins
2000
5 Citations (Scopus)

Application of nonionic surfactants combining hydrophobic and hydrophilic cholelitholytic solvents on dissolution of gallstones

Lim, M. Y., Chou, T. C., Lin, X-Z., Chen, C-Y., Ling, T. R. & Shiesh, S-C., 2000 Apr 15, In : Colloids and Surfaces B: Biointerfaces. 17, 4, p. 265-274 10 p.

Research output: Contribution to journalArticle

Nonionic surfactants
Gallstones
Surface-Active Agents
dissolving
Dissolution