• 2043 Citations
  • 28 h-Index
1988 …2019

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Amperometric detection of morphine at a Prussian blue-modified indium tin oxide electrode

Ho, K. C., Chen, C. Y., Hsu, H. C., Chen, L. C., Shiesh, S. C. & Lin, X. Z., 2004 Jul 30, In : Biosensors and Bioelectronics. 20, 1, p. 3-8 6 p.

Research output: Contribution to journalArticle

78 Citations (Scopus)

An automatic microfluidic system for rapid screening of cancer stem-like cell-specific aptamers

Weng, C. H., Hsieh, I. S., Hung, L. Y., Lin, H. I., Shiesh, S. C., Chen, Y. L. & Lee, G. B., 2013 Jan 1, In : Microfluidics and Nanofluidics. 14, 3-4, p. 753-765 13 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)

An automatic microfluidic system that continuously performs the systematic evolution of ligands by exponential enrichment

Chen, Y. H., Lin, H. I., Huang, C. J., Shiesh, S. C. & Lee, G. B., 2012 Dec 1, In : Microfluidics and Nanofluidics. 13, 6, p. 929-939 11 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

An integrated microfluidic platform to perform uninterrupted SELEX cycles to screen affinity reagents specific to cardiovascular biomarkers

Sinha, A., Gopinathan, P., Chung, Y., Lin, H., Li, K., Ma, H., Huang, P., Shiesh, S. & Lee, G., 2018 Dec 1, In : Biosensors and Bioelectronics. 122, p. 104-112

Research output: Contribution to journalArticle

9 Citations (Scopus)

An integrated microfluidic system for C-reactive protein measurement

Yang, Y. N., Lin, H. I., Wang, J. H., Shiesh, S. C. & Lee, G. B., 2009 Jun 15, In : Biosensors and Bioelectronics. 24, 10, p. 3091-3096 6 p.

Research output: Contribution to journalArticle

57 Citations (Scopus)

An integrated microfluidic system for fast, automatic detection of C-reactive protein

Lee, W. B., Chen, Y. H., Lin, H. I., Shiesh, S. C. & Lee, G. B., 2011 Oct 20, In : Sensors and Actuators, B: Chemical. 157, 2, p. 710-721 12 p.

Research output: Contribution to journalArticle

56 Citations (Scopus)

An integrated microfluidic system for measurement of glycated hemoglobin Levels by using an aptamer-antibody assay on magnetic beads

Chang, K. W., Li, J., Yang, C. H., Shiesh, S. C. & Lee, G. B., 2015 Jun 5, In : Biosensors and Bioelectronics. 68, p. 397-403 7 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

An integrated microfluidic system for on-chip enrichment and quantification of circulating extracellular vesicles from whole blood

Chen, Y. S., Ma, Y. D., Chen, C., Shiesh, S. C. & Lee, G. B., 2019 Jan 1, In : Lab on a Chip. 19, 19, p. 3305-3315 11 p.

Research output: Contribution to journalArticle

An integrated microfluidic system for rapid screening of alpha-fetoprotein-specific aptamers

Huang, C. J., Lin, H. I., Shiesh, S. C. & Lee, G. B., 2012 May 15, In : Biosensors and Bioelectronics. 35, 1, p. 50-55 6 p.

Research output: Contribution to journalArticle

63 Citations (Scopus)

An integrated microfluidic system with field-effect-transistor sensor arrays for detecting multiple cardiovascular biomarkers from clinical samples

Sinha, A., Tai, T. Y., Li, K. H., Gopinathan, P., Chung, Y. D., Sarangadharan, I., Ma, H. P., Huang, P. C., Shiesh, S-C., Wang, Y. L. & Lee, G. B., 2019 Mar 15, In : Biosensors and Bioelectronics. 129, p. 155-163 9 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Apolipoprotein C-III is an amyloid-β-binding protein and an early marker for Alzheimer's disease

Shih, Y. H., Tsai, K. J., Lee, C. W., Shiesh, S. C., Chen, W. T., Pai, M. C. & Kuo, Y. M., 2014 Jan 1, In : Journal of Alzheimer's disease : JAD. 41, 3, p. 855-865 11 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Application of nonionic surfactants combining hydrophobic and hydrophilic cholelitholytic solvents on dissolution of gallstones

Lim, M. Y., Chou, T. C., Lin, X. Z., Chen, C. Y., Ling, T. R. & Shiesh, S. C., 2000 Apr 15, In : Colloids and Surfaces B: Biointerfaces. 17, 4, p. 265-274 10 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Aptamer-functionalized AlGaN/GaN high-electron-mobility transistor for rapid diagnosis of fibrinogen in human plasma

Tai, T. Y., Sinha, A., Sarangadharan, I., Pulikkathodi, A. K., Wang, S. L., Shiesh, S. C., Lee, G. B. & Wang, Y. L., 2018 Jan 1, In : Sensors and Materials. 30, 10, p. 2321-2331 11 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Ascitic fluid analysis in peritoneal carcinomatosis: comparison of various biochemical tests with ascitic cirrhotics.

Lu, C. W., Wang, S. S., Lee, S. D., Tsai, Y. T., Lee, F. Y., Shiesh, S-C., Wu, S. L., Lu, R. H. & Lo, K. J., 1991 Jan 1, In : Zhonghua yi xue za zhi = Chinese medical journal; Free China ed. 47, 5, p. 350-356 7 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Attenuation of argininosuccinate lyase inhibits cancer growth via cyclin A2 and nitric oxide

Huang, H. L., Hsu, H. P., Shieh, S. C., Chang, Y. S., Chen, W. C., Cho, C. Y., Teng, C. F., Su, I. J., Hung, W. C. & Lai, M. D., 2013 Nov, In : Molecular Cancer Therapeutics. 12, 11, p. 2505-2516 12 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Bacterial density of Helicobacter pylori predicts the success of triple therapy in bleeding duodenal ulcer

Sheu, B. S., Yang, H. B., Su, I. J., Shiesh, S. C., Chi, C. H. & Lin, X. Z., 1996 Jan 1, In : Gastrointestinal Endoscopy. 44, 6, p. 683-688 6 p.

Research output: Contribution to journalArticle

69 Citations (Scopus)

Beyond the Debye length in high ionic strength solution: Direct protein detection with field-effect transistors (FETs) in human serum

Chu, C. H., Sarangadharan, I., Regmi, A., Chen, Y. W., Hsu, C. P., Chang, W. H., Lee, G. Y., Chyi, J. I., Chen, C. C., Shiesh, S. C., Lee, G. B. & Wang, Y. L., 2017 Dec 1, In : Scientific reports. 7, 1, 5256.

Research output: Contribution to journalArticle

67 Citations (Scopus)

Bile acid profiles in neonatal intrahepatic cholestasis caused by citrin deficiency

Yang, C. H., Chen, C. Y., Chou, Y. Y., Chiu, H. C., Tsai, W. L. & Shiesh, S. C., 2017 Dec, In : Clinica Chimica Acta. 475, p. 28-35 8 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Biliary sludge and pigment stone formation in bile duct-ligated guinea pigs

Chen, C. Y., Shiesh, S. C. & Lin, X. Z., 1999 Feb 3, In : Digestive Diseases and Sciences. 44, 1, p. 203-209 7 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Carbon monoxide may enhance bile secretion by increasing glutathione excretion and Mrp2 expression in rats

Chen, C. Y., Kao, C. Y., Lin, P. J. & Shiesh, S. C., 2013 May 1, In : Journal of the Chinese Medical Association. 76, 5, p. 258-264 7 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Clinical application of 20 MHz endosonography and anti-Helicobacter pylori immunoblots to predict regression of low-grade gastric MALtoma by H. pylori eradication

Sheu, B. S., Shiesh, S. C., Wang, J. T., Yang, H. B., Lin, S. T. & Wu, J. J., 2003 Apr 12, In : Helicobacter. 8, 1, p. 36-45 10 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Clinical significance of ultrasonography, computed tomography, and biochemical tests in the rapid diagnosis of gallstone-related pancreatitis: A prospective study

Wang, S. S., Lin, X. Z., Tsai, Y. T., Lee, S. D., Pan, H. B., Chou, Y. H., Su, C. H., Lee, C. H., Shiesh, S. C., Lin, C. Y. & Lin, H. C., 1988 Apr, In : Pancreas. 3, 2, p. 153-158 6 p.

Research output: Contribution to journalArticle

77 Citations (Scopus)
29 Citations (Scopus)

Correlation of serum levels of macrophage migration inhibitory factor with disease severity and clinical outcome in dengue patients

Chen, L. C., Lei, H. Y., Liu, C-C., Shiesh, S-C., Chen, S., Liu, H-S., Lin, Y-S., Wang, S-T., Shyu, H. W. & Yeh, T-M., 2006 Jan 1, In : American Journal of Tropical Medicine and Hygiene. 74, 1, p. 142-147 6 p.

Research output: Contribution to journalArticle

131 Citations (Scopus)

C-reactive protein for the evaluation of acute abdominal pain

Chi, C. H., Shiesh, S. C., Chen, K. W., Wu, M. H. & Lin, X. Z., 1996 Jan 1, In : American Journal of Emergency Medicine. 14, 3, p. 254-256 3 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Design and Demonstration of Tunable Amplified Sensitivity of AlGaN/GaN High Electron Mobility Transistor (HEMT)-Based Biosensors in Human Serum

Tai, T. Y., Sinha, A., Sarangadharan, I., Pulikkathodi, A. K., Wang, S. L., Lee, G. Y., Chyi, J. I., Shiesh, S. C., Lee, G. B. & Wang, Y. L., 2019 May 7, In : Analytical chemistry. 91, 9, p. 5953-5960 8 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Detection of C-reactive protein on an integrated microfluidic system by utilizing field-effect transistors and aptamers

Kao, W. C., Chen, Y. W., Chu, C. H., Chang, W. H., Shiesh, S. C., Wang, Y. L. & Lee, G. B., 2017 Jul 1, In : Biomicrofluidics. 11, 4, 044105.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Determination of C-reactive protein with an ultra-sensitivity immunochemiluminometric assay

Shiesh, S. C., Chou, T. C., Lin, X. Z. & Kao, P. C., 2006 Apr 20, In : Journal of Immunological Methods. 311, 1-2, p. 87-95 9 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Diagnostic role of biliary pancreatic elastase for cholangiocarcinoma in patients with cholestasis

Chen, C. Y., Tsai, W. L., Wu, H. C., Syu, M. J., Wu, C. C. & Shiesh, S. C., 2008 Apr 1, In : Clinica Chimica Acta. 390, 1-2, p. 82-89 8 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Direct detection of fibrinogen in human plasma using electric-double-layer gated AlGaN/GaN high electron mobility transistors

Regmi, A., Sarangadharan, I., Chen, Y. W., Hsu, C. P., Lee, G. Y., Chyi, J. I., Shiesh, S. C., Lee, G. B. & Wang, Y. L., 2017 Aug 21, In : Applied Physics Letters. 111, 8, 082106.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Enhanced dissolution of gallstone by combining ethanol with two commonly used cholelitholytic solvents

Lim, M. Y., Chou, T. C., Lin, X. Z., Chen, C. Y., Shiesh, S. C. & Ling, T. R., 1999 May 25, In : Hepato-Gastroenterology. 46, 26, p. 758-761 4 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Evaluation of topographic gastric histology in H. pylori infection - A comparative study with CLO test and bacterial culture

Yang, H. B., Sheu, B-S., Chien, C. H., Huang, A. H., Shiesh, S-C., Lin, X-Z., Wu, J. J. & Su, I. J., 1998 Jan 1, In : Tzu Chi Medical Journal. 10, 3, p. 165-172 8 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)

Field-effect transistor-based biosensors and a portable device for personal healthcare

Chen, P. C., Chen, Y. W., Sarangadharan, I., Hsu, C. P., Chen, C. C., Shiesh, S-C., Lee, G. B. & Wang, Y. L., 2017 Jan 1, In : ECS Journal of Solid State Science and Technology. 6, 7, p. Q71-Q76

Research output: Contribution to journalArticle

11 Citations (Scopus)

Glycine ameliorates liver injury and vitamin D deficiency induced by bile duct ligation

Chen, C-Y., Wang, B. T., Wu, Z. C., Yu, W. T., Lin, P. J., Tsai, W. L. & Shiesh, S-C., 2013 May 1, In : Clinica Chimica Acta. 420, p. 150-154 5 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Heavy bacterial loads of H. pylori may precipitate duodenal ulcer bleeding but not bleeding severity

Sheu, B-S., Chih-Hsein, C., Hsiao-Bai, Y., Shiesh, S-C. & Lin, X-Z., 1998 Dec 1, In : Hepato-Gastroenterology. 45, 24, p. 2165-2170 6 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

High oxidative stress is correlated with frailty in elderly Chinese

Wu, I. C., Shiesh, S. C., Kuo, P. H. & Lin, X. Z., 2009 Sep 1, In : Journal of the American Geriatrics Society. 57, 9, p. 1666-1671 6 p.

Research output: Contribution to journalArticle

71 Citations (Scopus)

High resolution melting analysis for the detection of SLC25A13 gene mutations in Taiwan

Lin, J. T., Hsiao, K. J., Chen, C. Y., Wu, C. C., Lin, S. J., Chou, Y. Y. & Shiesh, S. C., 2011 Feb 20, In : Clinica Chimica Acta. 412, 5-6, p. 460-465 6 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

High sensitivity cardiac troponin I detection in physiological environment using AlGaN/GaN High Electron Mobility Transistor (HEMT) Biosensors

Sarangadharan, I., Regmi, A., Chen, Y. W., Hsu, C. P., Chen, P. C., Chang, W. H., Lee, G. Y., Chyi, J. I., Shiesh, S. C., Lee, G. B. & Wang, Y. L., 2018 Feb 15, In : Biosensors and Bioelectronics. 100, p. 282-289 8 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)
11 Citations (Scopus)

Implications of Helicobacter pylori serological titer for the histological severity of antral gastritis

Sheu, B. S., Shiesh, S. C., Yang, H. B., Su, I. J., Chen, C. Y. & Lin, X. Z., 1997 Jan, In : Endoscopy. 29, 1, p. 27-30 4 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Increased aortic stiffness and attenuated lysyl oxidase activity in obesity

Chen, J. Y., Tsai, P. J., Tai, H. C., Tsai, R. L., Chang, Y. T., Wang, M. C., Chiou, Y. W., Yeh, M. L., Tang, M. J., Lam, C. F., Shiesh, S. C., Li, Y. H., Tsai, W. C., Chou, C. H., Lin, L. J., Wu, H. L. & Tsai, Y. S., 2013 Apr 1, In : Arteriosclerosis, thrombosis, and vascular biology. 33, 4, p. 839-846 8 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)
3 Citations (Scopus)

Integrated microfluidic system for rapid screening of CRP aptamers utilizing systematic evolution of ligands by exponential enrichment (SELEX)

Huang, C. J., Lin, H. I., Shiesh, S-C. & Lee, G. B., 2010 Mar 15, In : Biosensors and Bioelectronics. 25, 7, p. 1761-1766 6 p.

Research output: Contribution to journalArticle

94 Citations (Scopus)

Ionic effect on the binding of bilirubin to the imprinted poly(methacrylic acid-co-ethylene glycol dimethylacrylate)

Syu, M. J., Nian, Y. M., Chang, Y. S., Lin, X. Z., Shiesh, S. C. & Chou, T. C., 2006 Jul 28, In : Journal of Chromatography A. 1122, 1-2, p. 54-62 9 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)
88 Citations (Scopus)

Low serum testosterone and frailty in older men and women

Wu, I. C., Lin, X. Z., Liu, P. F., Tsai, W. L. & Shiesh, S. C., 2010 Dec 1, In : Maturitas. 67, 4, p. 348-352 5 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)

Measurement of creatine kinase isoforms by agarose gel electrophoresis in the diagnosis of myocardial infarction

Shiesh, S-C., Ting, W. K. & Jap, T. S., 1992 Jan 1, In : Clinical Biochemistry. 25, 4, p. 293-301 9 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Measurement of glycated hemoglobin levels using an integrated microfluidic system

Wu, C. C., Lin, H. I., Chang, K. W., Mai, J. D., Shiesh, S-C. & Lee, G. B., 2015 Jan 1, In : Microfluidics and Nanofluidics. 18, 4, p. 613-621 9 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Melatonin prevents pigment gallstone formation induced by bile duct ligation in guinea pigs

Shiesh, S-C., Chen, C-Y., Lin, X-Z., Liu, Z. A. & Tsao, H. C., 2000 Jan 1, In : Hepatology. 32, 3, p. 455-460 6 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)