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1988 …2019
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Research Output 1988 2019

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2019

Complete mapping of disulfide linkages for etanercept products by multi-enzyme digestion coupled with LC-MS/MS using multi-fragmentations including CID and ETD

Huang, L. J., Chiang, C. W., Chen, S. L., Wei, S. Y. & Chen, S-H., 2019 Apr 1, In : Journal of Food and Drug Analysis. 27, 2, p. 531-541 11 p.

Research output: Contribution to journalArticle

Chromosome Mapping
sulfides
Disulfides
electron transfer
Digestion

Fully galactosyl-fucosyl-bisected IgG 1 reduces anti-HBV efficacy and liver histological improvement

Ho, C. H., Chen, S-H., Tsai, H-W., Wu, I-C. & Chang, T-T., 2019 Mar 1, In : Antiviral Research. 163, p. 1-10 10 p.

Research output: Contribution to journalArticle

Hepatitis B virus
Immunoglobulin G
Liver
Hepatitis B e Antigens
Acetylglucosamine
2 Citations (Scopus)

Identifying reducing and capping sites of protein-encapsulated gold nanoclusters

Hsu, Y. C., Hung, M. J., Chen, Y. A., Wang, T. F., Ou, Y. R. & Chen, S-H., 2019 Apr 25, In : Molecules. 24, 8, 1630.

Research output: Contribution to journalArticle

Open Access
Nanoclusters
disulfides
nanoclusters
Gold
Disulfides
2018
3 Citations (Scopus)

In Situ Click Reaction Coupled with Quantitative Proteomics for Identifying Protein Targets of Catechol Estrogens

Liang, H., Liu, Y., Chen, H., Ku, M., Do, Q., Wang, C., Tzeng, S. & Chen, S-H., 2018 Aug 3, In : Journal of Proteome Research. 17, 8, p. 2590-2599

Research output: Contribution to journalArticle

1 Citation (Scopus)
Progesterone Receptors
Hepatocellular Carcinoma
Biomarkers
Membranes
Atlases
2017
7 Citations (Scopus)

Dimethyl Labeling Coupled with Mass Spectrometry for Topographical Characterization of Primary Amines on Monoclonal Antibodies

Jhan, S. Y., Huang, L. J., Wang, T. F., Chou, H-H. & Chen, S-H., 2017 Apr 4, In : Analytical Chemistry. 89, 7, p. 4255-4263 9 p.

Research output: Contribution to journalArticle

Labeling
Amines
Mass spectrometry
Monoclonal Antibodies
Lysine
1 Citation (Scopus)
Hepatitis B e Antigens
Immunoglobulin G
Hepatitis B virus
Serum
Therapeutics
2016
5 Citations (Scopus)

Characterization and comparability of stress-induced oxidation and deamidation on vulnerable sites of etanercept products

Huang, L. J., Chiang, C. W., Lee, Y. W., Wang, T. F., Fong, C. C. & Chen, S-H., 2016 Oct 1, In : Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 1032, p. 189-197 9 p.

Research output: Contribution to journalArticle

Bioactivity
Oxidation
Oxidative stress
Oxidative Stress
Liquid chromatography
5 Citations (Scopus)

RON nuclear translocation under hypoxia potentiates chemoresistance to DNA double-strand break-inducing anticancer drugs

Chang, H. Y., Chang, T. C., Huang, W-Y., Lee, C-T., Yen, C-J., Tsai, Y-S., Tzai, T. S., Chen, S-H. & Chow, N-H., 2016 Feb 1, In : Molecular Cancer Therapeutics. 15, 2, p. 276-286 11 p.

Research output: Contribution to journalArticle

Double-Stranded DNA Breaks
Pharmaceutical Preparations
DNA End-Joining Repair
DNA-Activated Protein Kinase
Epirubicin
7 Citations (Scopus)

Site-specific covalent modifications of human insulin by catechol estrogens: Reactivity and induced structural and functional changes

Ku, M. C., Fang, C. M., Cheng, J. T., Liang, H. C., Wang, T. F., Wu, C-H., Chen, C-C., Tai, J. H. & Chen, S-H., 2016 Jun 29, In : Scientific reports. 6, 28804.

Research output: Contribution to journalArticle

Catechol Estrogens
Insulin
Proteins
MCF-7 Cells
Circular Dichroism
4 Citations (Scopus)

Steroid Probes Conjugated with Protein-Protected Gold Nanocluster: Specific and Rapid Fluorescence Imaging of Steroid Receptors in Target Cells

Tsai, C. Y., Li, C. W., Li, J-R., Jang, B. H. & Chen, S-H., 2016 Jul 1, In : Journal of Fluorescence. 26, 4, p. 1239-1248 10 p.

Research output: Contribution to journalArticle

Steroid Receptors
Nanoclusters
internalization
Optical Imaging
Bovine Serum Albumin
2015
11 Citations (Scopus)

Aberrant serum immunoglobulin g glycosylation in chronic hepatitis b is associated with histological liver damage and reversible by antiviral therapy

Ho, C. H., Chien, R. N., Cheng, P. N., Liu, J. H., Liu, C. K., Su, C. S., Wu, I. C., Li, I. C., Tsai, H. W., Wu, S. L., Liu, W. C., Chen, S. H. & Chang, T. T., 2015 Jan 1, In : Journal of Infectious Diseases. 211, 1, p. 115-124 10 p.

Research output: Contribution to journalArticle

Chronic Hepatitis
Glycosylation
Antiviral Agents
Immunoglobulins
Chronic Hepatitis B
17 Citations (Scopus)

Autophagic degradation of aquaporin-2 is an early event in hypokalemia-induced nephrogenic diabetes insipidus

Khositseth, S., Uawithya, P., Somparn, P., Charngkaew, K., Thippamom, N., Hoffert, J. D., Saeed, F., Payne, D. M., Chen, S. H., Fenton, R. A. & Pisitkun, T., 2015 Dec 17, In : Scientific reports. 5, 18311.

Research output: Contribution to journalArticle

Aquaporin 2
Nephrogenic Diabetes Insipidus
Hypokalemia
Potassium
Electron Microscopy
5 Citations (Scopus)

Identification of endogenous site-specific covalent binding of catechol estrogens to serum proteins in human blood

Fang, C. M., Ku, M. C., Chang, C. K., Liang, H. C., Wang, T. F., Wu, C-H. & Chen, S-H., 2015 Dec 1, In : Toxicological Sciences. 148, 2, p. 433-442 10 p.

Research output: Contribution to journalArticle

Catechol Estrogens
Blood Proteins
Blood
Estrogens
Biomarkers
4 Citations (Scopus)

In situ fabrication of cleavable peptide arrays on polydimethylsiloxane and applications for kinase activity assays

Chen, H. H., Hsiao, Y. C., Li, J-R. & Chen, S-H., 2015 Jan 1, In : Analytica Chimica Acta. 865, 1, p. 53-59 7 p.

Research output: Contribution to journalArticle

kemptide
peptide
Assays
Phosphotransferases
assay
10 Citations (Scopus)

SH3BGRL3 Protein as a Potential Prognostic Biomarker for Urothelial Carcinoma: A Novel Binding Partner of Epidermal Growth Factor Receptor

Chiang, C. Y., Pan, C. C., Chang, H. Y., Lai, M-D., Tzai, T. S., Tsai, Y-S., Ling, P., Liu, H-S., Lee, B-F., Cheng, H-L., Ho, C-L., Chen, S-H. & Chow, N-H., 2015 Dec 15, In : Clinical Cancer Research. 21, 24, p. 5601-5611 11 p.

Research output: Contribution to journalArticle

src Homology Domains
Epidermal Growth Factor Receptor
Glutamic Acid
Biomarkers
Carcinoma
2014
4 Citations (Scopus)

Association of serum IgG N-glycome and transforming growth factor-β1 with hepatitis B virus e antigen seroconversion during entecavir therapy

Ho, C. H., Chien, R. N., Cheng, P. N., Liu, C. K., Su, C. S., Wu, I. C., Liu, W. C., Chen, S. H. & Chang, T. T., 2014 Jan 1, In : Antiviral Research. 111, p. 121-128 8 p.

Research output: Contribution to journalArticle

Hepatitis B e Antigens
Transforming Growth Factors
Hepatitis B virus
Immunoglobulin G
Chronic Hepatitis B
15 Citations (Scopus)

Identification of protein O-glycosylation site and corresponding glycans using liquid chromatography-tandem mass spectrometry via mapping accurate mass and retention time shift

Huang, L. J., Lin, J. H., Tsai, J. H., Chu, Y. Y., Chen, Y. W., Chen, S. L. & Chen, S-H., 2014 Dec 5, In : Journal of Chromatography A. 1371, p. 136-145 10 p.

Research output: Contribution to journalArticle

Glycosylation
Liquid chromatography
Tandem Mass Spectrometry
Liquid Chromatography
Mass spectrometry
8 Citations (Scopus)

In-depth comparative characterization of hemoglobin glycation in normal and diabetic bloods by LC-MSMS

Wang, S. H., Wang, T. F., Wu, C-H. & Chen, S-H., 2014 Jan 1, In : Journal of the American Society for Mass Spectrometry. 25, 5, p. 758-766 9 p.

Research output: Contribution to journalArticle

Hemoglobins
Blood
Globins
Molecular Conformation
Glucose
5 Citations (Scopus)

Signal transduction triggered by iron to induce the nuclear importation of a Myb3 transcription factor in the parasitic protozoan Trichomonas vaginalis

Hsu, H. M., Lee, Y., Hsu, P. H., Liu, H. W., Chu, C. H., Chou, Y. W., Chen, Y. R., Chen, S. H. & Tai, J. H., 2014 Oct 17, In : Journal of Biological Chemistry. 289, 42, p. 29334-29349 16 p.

Research output: Contribution to journalArticle

Trichomonas vaginalis
Signal transduction
Signal Transduction
Transcription Factors
Iron
3 Citations (Scopus)

Using hidden Markov models to predict DNA-binding proteins with sequence and structure information

Hsu, Y. Y., Chen, W. J., Chen, S-H. & Kao, H-Y., 2014 Jan 1, In : Soft Computing. 18, 12, p. 2365-2376 12 p.

Research output: Contribution to journalArticle

DNA-binding Protein
Information Structure
Hidden Markov models
Markov Model
DNA
2013
22 Citations (Scopus)

A global comparability approach for biosimilar monoclonal antibodies using LC-tandem MS based proteomics

Chen, S. L., Wu, S. L., Huang, L. J., Huang, J. B. & Chen, S-H., 2013 Jun 1, In : Journal of Pharmaceutical and Biomedical Analysis. 80, p. 126-135 10 p.

Research output: Contribution to journalArticle

Biosimilar Pharmaceuticals
Proteomics
Monoclonal Antibodies
Peptides
Peptide Mapping
19 Citations (Scopus)

Community and proteomic analysis of methanogenic consortia degrading terephthalate

Wu, J. H., Wu, F. Y., Chuang, H. P., Chen, W. Y., Huang, H. J., Chen, S. H. & Liu, W. T., 2013 Jan 1, In : Applied and environmental microbiology. 79, 1, p. 105-112 8 p.

Research output: Contribution to journalArticle

proteomics
Proteomics
butyrates
protein
Butyrates
18 Citations (Scopus)

Improved Nα-acetylated peptide enrichment following dimethyl labeling and SCX

Chen, S. H., Chen, C. R., Chen, S. H., Li, D. T. & Hsu, J. L., 2013 Jul 5, In : Journal of Proteome Research. 12, 7, p. 3277-3287 11 p.

Research output: Contribution to journalArticle

Labeling
Cations
Acetylation
Ion exchange
Peptides
5 Citations (Scopus)

Two new blue-phosphorescent Ir(III) cyclometalated complexes demonstrating the pushing-up effects of amino on levels of Pi-type molecular orbitals

Chen, W. T., Chen, Y. J., Wu, C. S., Lin, J. J., Su, W. L., Chen, S-H. & Wang, S. P., 2013 Jul 19, In : Inorganica Chimica Acta. 408, p. 225-229 5 p.

Research output: Contribution to journalArticle

pushing
destabilization
Molecular orbitals
Amines
molecular orbitals
2012
26 Citations (Scopus)
Glycosylated Hemoglobin A
Microarrays
Blood
Antibodies
Hemoglobins
2 Citations (Scopus)

Gold nanoparticle-based immuno dual probes for targeting proteomics

Chen, C. H., Hong, J. X., Wu, C. S. & Chen, S. H., 2012 Jul 6, In : Journal of Proteome Research. 11, 7, p. 3921-3928 8 p.

Research output: Contribution to journalArticle

Gold
Proteomics
Nanoparticles
Immunoglobulin G
Proteins
47 Citations (Scopus)

Magnetic bead-based hydrophilic interaction liquid chromatography for glycopeptide enrichments

Yeh, C. H., Chen, S-H., Li, D. T., Lin, H-P., Huang, H. J., Chang, C. I., Shih, W. L., Chern, C. L., Shi, F. K. & Hsu, J. L., 2012 Feb 10, In : Journal of Chromatography A. 1224, p. 70-78 9 p.

Research output: Contribution to journalArticle

Glycopeptides
Liquid chromatography
Hydrophobic and Hydrophilic Interactions
Liquid Chromatography
Nanoparticles
15 Citations (Scopus)

The effect of exogenous histone H1 on rat adipose-derived stem cell proliferation, migration, and osteogenic differentiation in vitro

Hsu, L. W., Goto, S., Nakano, T., Chen, K. D., Wang, C. C., Lai, C. Y., Hou, C. H., Chang, Y. C., Cheng, Y. F., Chiu, K. W., Chen, C. C., Chen, S. H. & Chen, C. L., 2012 Oct 1, In : Journal of Cellular Physiology. 227, 10, p. 3417-3425 9 p.

Research output: Contribution to journalArticle

Cell proliferation
Stem cells
Histones
Cell Movement
Rats
2011
5 Citations (Scopus)

Diverse macroporous spheres synthesized by multiple emulsion polymerization for protein analyses

Liang, S. S., Chen, S. L. & Chen, S-H., 2011 Aug 7, In : Chemical Communications. 47, 29, p. 8385-8387 3 p.

Research output: Contribution to journalArticle

Emulsion polymerization
Proteins
Trypsin
25 Citations (Scopus)

Heat shock protein 90 stabilizes nucleolin to increase mRNA stability in mitosis

Wang, S. A., Li, H. Y., Hsu, T. I., Chen, S. H., Wu, C. J., Chang, W. C. & Hung, J. J., 2011 Dec 23, In : Journal of Biological Chemistry. 286, 51, p. 43816-43829 14 p.

Research output: Contribution to journalArticle

HSP90 Heat-Shock Proteins
RNA Stability
Mitosis
Messenger RNA
Carcinogenesis
17 Citations (Scopus)
Liquid chromatography
Metabolites
Tandem Mass Spectrometry
Liquid Chromatography
Mass spectrometry
41 Citations (Scopus)
Isotope Labeling
Affinity chromatography
Phosphorylation
Liquid chromatography
Hydrophobic and Hydrophilic Interactions
22 Citations (Scopus)

Quantitative shot-gun proteomics and MS-based activity assay for revealing gender differences in enzyme contents for rat liver microsome

Huang, H. J., Tsai, M-L., Chen, Y. W. & Chen, S-H., 2011 Nov 18, In : Journal of Proteomics. 74, 12, p. 2734-2744 11 p.

Research output: Contribution to journalArticle

Firearms
Liver Microsomes
Liver
Proteomics
Mass spectrometry
10 Citations (Scopus)

Urinary CD14 as a potential biomarker for benign prostatic hyperplasia - discovery by combining MALDI-TOF-based biostatistics and ESI-MS/MS-based stable-isotope labeling

Cheng, H-L., Huang, H. J., Ou, B. Y., Chow, N-H., Chen, Y. W., Tzai, T. S., Wu, C. J. & Chen, S-H., 2011 Apr 1, In : Proteomics - Clinical Applications. 5, 3-4, p. 121-132 12 p.

Research output: Contribution to journalArticle

Biostatistics
Isotope Labeling
Matrix-Assisted Laser Desorption-Ionization Mass Spectrometry
Prostatic Hyperplasia
Biomarkers
2010
7 Citations (Scopus)

5-(Perfluorooctylthio)acetamidofluorescein (5-FOAF) as a convenient tag for inspecting the surface coverage of fluorinated coatings

Li, Y. T., Chen, H. H., Babu, B. H., Hsieh, Y. Y. & Chen, S-H., 2010 Sep 1, In : Applied Surface Science. 256, 22, p. 6908-6913 6 p.

Research output: Contribution to journalArticle

Coatings
Silicon Dioxide
Metals
Fluorescence
Silica
4 Citations (Scopus)

Functional fluorinated modifications on a polyelectrolyte coated polydimethylsiloxane substrate for fabricating antibody microarrays

Chen, H. H., Sung, W. C., Liang, S. S. & Chen, S. H., 2010 Sep 15, In : Analytical chemistry. 82, 18, p. 7804-7813 10 p.

Research output: Contribution to journalArticle

Microarrays
Polyelectrolytes
Antibodies
Substrates
Coatings
10 Citations (Scopus)

Mapping N-Terminus Phosphorylation Sites and Quantitation by Stable Isotope Dimethyl Labeling

Wu, C. J., Hsu, J. L., Huang, S. Y. & Chen, S-H., 2010 Mar 1, In : Journal of the American Society for Mass Spectrometry. 21, 3, p. 460-471 12 p.

Research output: Contribution to journalArticle

Isotope Labeling
Phosphorylation
Isotopes
Labeling
Ions
19 Citations (Scopus)

Nucleophosmin in the pathogenesis of arsenic-related bladder carcinogenesis revealed by quantitative proteomics

Chen, S. H., Wang, Y. W., Hsu, J. L., Chang, H. Y., Wang, C. Y., Shen, P. T., Chiang, C. W., Chuang, J. J., Tsai, H. W., Gu, P. W., Chang, F. C., Liu, H. S. & Chow, N. H., 2010 Jan 15, In : Toxicology and Applied Pharmacology. 242, 2, p. 126-135 10 p.

Research output: Contribution to journalArticle

Arsenic
Proteomics
Carcinogenesis
Urinary Bladder
Mass spectrometry
26 Citations (Scopus)

Quantitative nanoproteomics for protein complexes (QNanoPX) related to estrogen transcriptional action

Cheng, P. C., Chang, H. K. & Chen, S-H., 2010 Feb 1, In : Molecular and Cellular Proteomics. 9, 2, p. 209-224 16 p.

Research output: Contribution to journalArticle

Response Elements
Estrogens
Proteins
Estrogen Receptors
Proteomics
2009

Enhancement of vascular formation but not improvement of ventricular function of infarcted rat hearts by a high dose of adenovirus-carried VEGF transgene

Sung, R. J., Chen, S-H., Luo, C-Y., Wang, J-N., Wu, C-L., Chen, Y. H., Su, R. J., Li, H. J. & Tsai, M-L., 2009 Jan 1, In : Chinese Journal of Physiology. 52, SUPPL. 5, p. 384-394 11 p.

Research output: Contribution to journalArticle

Ventricular Function
Transgenes
Adenoviridae
Vascular Endothelial Growth Factor A
Blood Vessels
25 Citations (Scopus)

Functionalized 3D-hydrogel plugs covalently patterned inside hydrophilic poly(dimethylsiloxane) microchannels for flow-through immunoassays

Sung, W. C., Chen, H. H., Makamba, H. & Chen, S. H., 2009 Oct 1, In : Analytical chemistry. 81, 19, p. 7967-7973 7 p.

Research output: Contribution to journalArticle

Hydrogel
Microchannels
Polyelectrolytes
Microfluidics
Multilayers
6 Citations (Scopus)
Hemeproteins
Response Elements
Heme
Gold
Multilayers
16 Citations (Scopus)

Monolithic microextraction tips by emulsion photopolymerization

Liang, S. S. & Chen, S-H., 2009 Mar 20, In : Journal of Chromatography A. 1216, 12, p. 2282-2287 6 p.

Research output: Contribution to journalArticle

Photopolymerization
Emulsions
Caseins
Recovery
Rigid structures
2008
12 Citations (Scopus)

Fluorescein as a versatile tag for enhanced selectivity in analyzing cysteine-containing proteins/peptides using mass spectrometry

Chen, S-H., Hsu, J. L. & Lin, F. S., 2008 Jul 1, In : Analytical Chemistry. 80, 13, p. 5251-5259 9 p.

Research output: Contribution to journalArticle

Fluorescein
Mass spectrometry
Cysteine
Peptides
Proteins
22 Citations (Scopus)

Integrated isotachophoretic stacking and gel electrophoresis on a plastic substrate and variations in detection dynamic range

Lin, C. C., Hsu, B. K. & Chen, S-H., 2008 Mar 1, In : Electrophoresis. 29, 6, p. 1228-1236 9 p.

Research output: Contribution to journalArticle

Inosine Triphosphate
Electrophoresis
Plastics
Gels
Substrates
36 Citations (Scopus)

Long-term affinity modification on poly(dimethylsiloxane) substrate and its application for ELISA analysis

Sung, W. C., Chang, C-C., Makamba, H. & Chen, S-H., 2008 Mar 1, In : Analytical Chemistry. 80, 5, p. 1529-1535 7 p.

Research output: Contribution to journalArticle

Dimethylpolysiloxanes
Immunosorbents
Assays
Substrates
Enzymes
11 Citations (Scopus)

Photopatterning of tough single-walled carbon nanotube composites in microfluidic channels and their application in gel-free separations

Makamba, H., Huang, J. W., Chen, H. H. & Chen, S. H., 2008 Jun 1, In : Electrophoresis. 29, 12, p. 2458-2465 8 p.

Research output: Contribution to journalArticle

Nanocomposites
Carbon Nanotubes
Microfluidics
Single-walled carbon nanotubes (SWCN)
Hydrogels
13 Citations (Scopus)

The role of a nuclear protein, histone H1, on signalling pathways for the maturation of dendritic cells

Hsu, L. W., Chen, C. L., Nakano, T., Lai, C. Y., Chiang, K. C., Lin, Y. C., Kao, Y. H., Chen, S-H., Goto, T., Sung, W. C., Yang, C. H., Cheng, Y. F., Jawan, B., Chiu, K. W. & Goto, S., 2008 Jun 1, In : Clinical and Experimental Immunology. 152, 3, p. 576-584 9 p.

Research output: Contribution to journalArticle

Nuclear Proteins
Histones
Dendritic Cells
p38 Mitogen-Activated Protein Kinases
Cytoplasm
2 Citations (Scopus)
Firearms
Proteomics
Trypsin
Uterus
Rats