• 587 Citations
  • 11 h-Index
20012019
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Research Output 2001 2019

  • 587 Citations
  • 11 h-Index
  • 29 Article
  • 3 Review article
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Article
2019

Functional Relevance of Interleukin-1 Receptor Inter-domain Flexibility for Cytokine Binding and Signaling

Ge, J., Remesh, S. G., Hammel, M., Pan, S., Mahan, A. D., Wang, S-Y. & Wang, X., 2019 Aug 6, In : Structure. 27, 8, p. 1296-1307.e5

Research output: Contribution to journalArticle

Interleukin-1 Receptors
Cytokines
Signal Transduction
Ligands
2018
3 Citations (Scopus)

Dextromethorphan attenuates NADPH oxidase-regulated glycogen synthase kinase 3 and NF-B activation and reduces nitric oxide production in group a streptococcal infection

Chen, C. L., Cheng, M. H., Kuo, C. F., Cheng, Y. L., Li, M. H., Chang, C. P., Wu, J. J., Anderson, R., Wang, S., Tsai, P-J., Liu, C. C. & Linc, Y. S., 2018 Jun, In : Antimicrobial agents and chemotherapy. 62, 6, e02045-17.

Research output: Contribution to journalArticle

Dextromethorphan
Glycogen Synthase Kinase 3
Streptococcal Infections
NADPH Oxidase
Streptococcus

NAD-glycohydrolase depletes intracellular NAD+ and inhibits acidification of autophagosomes to enhance multiplication of group A Streptococcus in endothelial cells

Hsieh, C. L., Huang, H. M., Hsieh, S. Y., Zheng, P. X., Lin, Y-S., Chiang-Ni, C., Tsai, P-J., Wang, S-Y., Liu, C-C. & Wu, J. J., 2018 Aug 3, In : Frontiers in Microbiology. 9, AUG, 1733.

Research output: Contribution to journalArticle

NAD+ Nucleosidase
Streptococcus
NAD
Endothelial Cells
Vacuoles
7 Citations (Scopus)

Structural Definition of a Unique Neutralization Epitope on the Receptor-Binding Domain of MERS-CoV Spike Glycoprotein

Zhang, S., Zhou, P., Wang, P., Li, Y., Jiang, L., Jia, W., Wang, H., Fan, A., Wang, D., Shi, X., Fang, X., Hammel, M., Wang, S-Y., Wang, X. & Zhang, L., 2018 Jul 10, In : Cell Reports. 24, 2, p. 441-452 12 p.

Research output: Contribution to journalArticle

Functional analysis
Neutralizing Antibodies
Structural analysis
Epitopes
Glycoproteins

Structural insights into the duplex DNA processing of TREX2

Cheng, H. L., Lin, C. T., Huang, K. W., Wang, S-Y., Lin, Y. T., Toh, S. I. & Hsiao, Y. Y., 2018 Jan 1, In : Nucleic acids research. 46, 22, p. 12166-12176 11 p.

Research output: Contribution to journalArticle

Open Access
Exonucleases
DNA
Skin
Genomic Instability
Psoriasis
2017
15 Citations (Scopus)

Exophagy of annexin A2 via RAB11, RAB8A and RAB27A in IFN-γ-stimulated lung epithelial cells

Chen, Y. D., Fang, Y. T., Cheng, Y. L., Lin, C. F., Hsu, L-J., Wang, S-Y., Anderson, R., Chang, C-P. & Lin, Y-S., 2017 Dec 1, In : Scientific reports. 7, 1, 5676.

Research output: Contribution to journalArticle

Annexin A2
Annexins
Epithelial Cells
Lung
Multivesicular Bodies
3 Citations (Scopus)
Flagella
Helicobacter pylori
Genes
Sigma Factor
Glycosyltransferases
8 Citations (Scopus)

Therapeutic effects of monoclonal antibody against dengue virus NS1 in a STAT1 knockout mouse model of dengue infection

Wan, S. W., Chen, P. W., Chen, C. Y., Lai, Y. C., Chu, Y. T., Hung, C. Y., Lee, H., Wu, H. F., Chuang, Y. C., Lin, J., Chang, C-P., Wang, S-Y., Liu, C-C., Ho, T-S., Lin, C. F., Lee, C. K., Wu-Hsieh, B. A., Anderson, R., Yeh, T-M. & Lin, Y-S., 2017 Oct 15, In : Journal of Immunology. 199, 8, p. 2834-2844 11 p.

Research output: Contribution to journalArticle

Dengue Virus
Dengue
Therapeutic Uses
Knockout Mice
Monoclonal Antibodies
2016
4 Citations (Scopus)

Attenuation of cancer-initiating cells stemness properties by abrogating S100A4 calcium binding ability in head and neck cancers

Cheng, L. H., Hung, K. F., Huang, T. F., Hsieh, H. P., Wang, S-Y., Huang, C. Y. & Lo, J. F., 2016 Jan 1, In : Oncotarget. 7, 48, p. 78946-78957 12 p.

Research output: Contribution to journalArticle

Mutant Proteins
Head and Neck Neoplasms
Calcium
Neoplasms
Calcium-Binding Proteins
5 Citations (Scopus)

Conformational sampling and binding site assessment of suppression of tumorigenicity 2 ectodomain

Yang, C. Y., Delproposto, J., Chinnaswamy, K., Brown, W. C., Wang, S-Y., Stuckey, J. A. & Wang, X., 2016 Jan 6, In : PloS one. 11, 1, e0146522.

Research output: Contribution to journalArticle

crystal structure
Conformations
binding sites
Binding Sites
Sampling
15 Citations (Scopus)

Dengue virus nonstructural protein 1-induced antibodies cross-react with human plasminogen and enhance its activation

Chuang, Y. C., Lin, J., Lin, Y-S., Wang, S-Y. & Yeh, T-M., 2016 Feb 1, In : Journal of Immunology. 196, 3, p. 1218-1226 9 p.

Research output: Contribution to journalArticle

Severe Dengue
Dengue Virus
Plasminogen
Antibodies
Proteins
2 Citations (Scopus)

Epidemiology analysis of streptococcus pyogenes in a hospital in Southern Taiwan by use of the updated emm cluster typing system

Chiang-Ni, C., Zheng, P. X., Wang, S-Y., Tsai, P-J., Chuang, W-J., Lin, Y-S., Liu, C-C. & Wu, J. J., 2016 Jan 1, In : Journal of Clinical Microbiology. 54, 1, p. 157-162 6 p.

Research output: Contribution to journalArticle

Streptococcus pyogenes
Streptococcus
Taiwan
Epidemiology
Molecular Typing
1 Citation (Scopus)

Streptococcal pyrogenic exotoxin B inhibits apoptotic cell clearance by macrophages through protein S cleavage

Chen, C. L., Wu, Y. Y., Lin, C. F., Kuo, C. F., Han, C. L., Wang, S-Y., Chuang, W-J., Chen, C. Y., Wu, J. J., Tsai, P-J., Liu, C-C. & Lin, Y-S., 2016 May 16, In : Scientific reports. 6, 26026.

Research output: Contribution to journalArticle

Protein S
Macrophages
streptopain
Streptococcus
Phagocytosis
3 Citations (Scopus)

Structural insights into substrate recognition by Clostridium difficile sortase

Yin, J. C., Fei, C. H., Lo, Y. C., Hsiao, Y. Y., Chang, J. C., Nix, J. C., Chang, Y. Y., Yang, L. W., Huang, I-H. & Wang, S-Y., 2016 Nov 22, In : Frontiers in Cellular and Infection Microbiology. 6, NOV, 160.

Research output: Contribution to journalArticle

Clostridium difficile
Cell Wall
Peptidyl Transferases
Fluorescence Resonance Energy Transfer
Peptides
2015
1 Citation (Scopus)

Clustered regularly interspaced short palindromic repeats are emm type-specific in highly prevalent group A streptococci

Zheng, P. X., Chan, Y. C., Chiou, C. S., Chiang-Ni, C., Wang, S-Y., Tsai, P-J., Chuang, W-J., Lin, Y-S., Liu, C-C. & Wu, J. J., 2015 Dec 1, In : PloS one. 10, 12, e0145223.

Research output: Contribution to journalArticle

Clustered Regularly Interspaced Short Palindromic Repeats
Streptococcus
molecular epidemiology
loci
nucleic acids
2014
3 Citations (Scopus)
Clustered Regularly Interspaced Short Palindromic Repeats
Erythromycin
Streptococcus
Nucleic Acids
Streptococcus pyogenes
9 Citations (Scopus)

Distinct structural features of the peroxide response regulator from group A streptococcus drive DNA binding

Lin, C. S. H., Chao, S. Y., Hammel, M., Nix, J. C., Tseng, H. L., Tsou, C. C., Fei, C. H., Chiou, H. S., Jeng, U. S., Lin, Y-S., Chuang, W-J., Wu, J. J. & Wang, S-Y., 2014 Feb 21, In : PloS one. 9, 2, e89027.

Research output: Contribution to journalArticle

Streptococcus
Peroxides
peroxides
DNA
X ray scattering
5 Citations (Scopus)

Invasive hypermucoid variant of group A Streptococcus is defective in growth and susceptible to DNA-damaging treatments

Chiang-Ni, C., Zheng, P. X., Wang, S-Y., Tsai, P-J., Kuo, C. F., Chuang, W-J., Lin, Y-S., Liu, C-C. & Wu, J. J., 2014 Jan 1, In : Pathogens and Disease. 70, 2, p. 194-201 8 p.

Research output: Contribution to journalArticle

Streptococcus
Capsules
DNA
Growth
Virulence
2013
11 Citations (Scopus)
Necrotizing Fasciitis
Streptococcus pyogenes
Pandemics
Genome
10 Citations (Scopus)

Peroxide responsive regulator PerR of group A streptococcus is required for the expression of phage-associated DNase Sda1 under oxidative stress

Wang, C. H., Chiang-Ni, C., Kuo, H. T., Zheng, P. X., Tsou, C. C., Wang, S., Tsai, P. J., Chuang, W. J., Lin, Y. S., Liu, C. C. & Wu, J. J., 2013 Dec 3, In : PloS one. 8, 12, e81882.

Research output: Contribution to journalArticle

deoxyribonucleases
Bacteriophages
Oxidative stress
Deoxyribonucleases
Streptococcus
75 Citations (Scopus)

Structural insights into the interaction of IL-33 with its receptors

Liu, X., Hammel, M., He, Y., Tainer, J. A., Jeng, U. S., Zhang, L., Wang, S-Y. & Wang, X., 2013 Sep 10, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 37, p. 14918-14923 6 p.

Research output: Contribution to journalArticle

Interleukins
Interleukin-1
Ligands
Interleukin-1 Receptors
Interleukin-1 Receptor Accessory Protein
51 Citations (Scopus)

The truncated C-terminal RNA recognition motif of TDP-43 protein plays a key role in forming proteinaceous aggregates

Wang, Y. T., Kuo, P. H., Chiang, C. H., Liang, J. R., Chen, Y. R., Wang, S., Shen, J. C. K. & Yuan, H. S., 2013 Mar 29, In : Journal of Biological Chemistry. 288, 13, p. 9049-9057 9 p.

Research output: Contribution to journalArticle

Inclusion Bodies
Glycine
Frontotemporal Lobar Degeneration
RNA
Negative Staining
2012
8 Citations (Scopus)

Crystal structure of a human single domain antibody dimer formed through V H-V H non-covalent interactions

Baral, T. N., Chao, S. Y., Li, S., Tanha, J., Arbabi-Ghahroudi, M., Zhang, J. & Wang, S-Y., 2012 Jan 12, In : PloS one. 7, 1, e30149.

Research output: Contribution to journalArticle

Single-Domain Antibodies
crystal structure
Dimers
Crystal structure
antibodies
2010
10 Citations (Scopus)

Annexin A2 on lung epithelial cell surface is recognized by severe acute respiratory syndrome-associated coronavirus spike domain 2 antibodies

Fang, Y. T., Lin, C. F., Liao, P. C., Kuo, Y. M., Wang, S., Yeh, T. M., Shieh, C. C. K., Su, I. J., Lei, H. Y. & Lin, Y. S., 2010 Feb 1, In : Molecular Immunology. 47, 5, p. 1000-1009 10 p.

Research output: Contribution to journalArticle

Annexin A2
Severe Acute Respiratory Syndrome
Coronavirus
Epithelial Cells
Lung
2008
23 Citations (Scopus)

The Bacillus subtilis RNA helicase YxiN is distended in solution

Wang, S-Y., Overgaard, M. T., Hu, Y. X. & McKay, D. B., 2008 Jan 1, In : Biophysical Journal. 94, 1

Research output: Contribution to journalArticle

RNA Helicases
Bacillus subtilis
RNA
Proteins
X-Rays
2007
62 Citations (Scopus)
Molecular Chaperones
Peptidylprolyl Isomerase
Peptides
Aromatic Amino Acids
Calorimetry
2006
95 Citations (Scopus)

Structure of the Escherichia coli FlhDC complex, a prokaryotic heteromeric regulator of transcription

Wang, S-Y., Fleming, R. T., Westbrook, E. M., Matsumura, P. & McKay, D. B., 2006 Jan 27, In : Journal of Molecular Biology. 355, 4, p. 798-808 11 p.

Research output: Contribution to journalArticle

Escherichia coli
DNA
Protein Subunits
Operon
Base Pairing
50 Citations (Scopus)

The domain of the Bacillus subtilis DEAD-box helicase YxiN that is responsible for specific binding of 23S rRNA has an RNA recognition motif fold

Wang, S-Y., Hu, Y., Overgaard, M. T., Karginov, F. V., Uhlenbeck, O. C. & McKay, D. B., 2006 Jun 1, In : RNA. 12, 6, p. 959-967 9 p.

Research output: Contribution to journalArticle

Bacillus subtilis
RNA
23S Ribosomal RNA
DEAD-box RNA Helicases
Ribonucleoproteins
2001
2 Citations (Scopus)

Crystallization and preliminary x-ray crystallographic analysis of FlhD/FlhC complex from Escherichia coli

Wang, S-Y., Matsumura, P. & Westbrook, E. M., 2001 May 21, In : Acta Crystallographica Section D: Biological Crystallography. 57, 5, p. 734-736 3 p.

Research output: Contribution to journalArticle

Crystallization
X-Rays
Escherichia coli
Proteins
DNA