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Research Output 1987 2019

2019

Dengue virus nonstructural protein 1 activates platelets via Toll-like receptor 4, leading to thrombocytopenia and hemorrhage

Chao, C. H., Wu, W. C., Lai, Y. C., Tsai, P. J., Perng, G-C., Lin, Y. S. & Yeh, T-M., 2019 Apr 1, In : PLoS pathogens. 15, 4, p. e1007625

Research output: Contribution to journalArticle

Open Access
Dengue Virus
Toll-Like Receptor 4
Thrombocytopenia
Blood Platelets
Hemorrhage

Inhibition of autophagy protects against sepsis by concurrently attenuating the cytokine storm and vascular leakage

Lu, L. H., Chao, C. H. & Yeh, T-M., 2019 Mar 1, In : Journal of Infection. 78, 3, p. 178-186 9 p.

Research output: Contribution to journalArticle

Autophagy
Blood Vessels
Sepsis
Cytokines
Lipopolysaccharides
2018
11 Citations (Scopus)

Dengue virus-induced ER stress is required for autophagy activation, viral replication, and pathogenesis both in vitro and in vivo

Lee, Y. R., Kuo, S. H., Lin, C. Y., Fu, P. J., Lin, Y-S., Yeh, T-M. & Liu, H-S., 2018 Dec 1, In : Scientific reports. 8, 1, 489.

Research output: Contribution to journalArticle

Virus Activation
Dengue Virus
Endoplasmic Reticulum Stress
Autophagy
Virus Diseases
1 Citation (Scopus)

Dengue virus non-structural protein 1: A pathogenic factor, therapeutic target, and vaccine candidate

Chen, H. R., Lai, Y. C. & Yeh, T-M., 2018 Jul 24, In : Journal of biomedical science. 25, 1, 58.

Research output: Contribution to journalReview article

Viral Structural Proteins
Severe Dengue
Dengue Virus
Viruses
Vaccines
5 Citations (Scopus)

Macrophage Migration Inhibitory Factor-Induced Autophagy Contributes to Thrombin-Triggered Endothelial Hyperpermeability in Sepsis

Chao, C. H., Chen, H. R., Chuang, Y. C. & Yeh, T-M., 2018 Jul 1, In : Shock. 50, 1, p. 103-111 9 p.

Research output: Contribution to journalArticle

Macrophage Migration-Inhibitory Factors
Autophagy
Thrombin
Sepsis
Blood Vessels
3 Citations (Scopus)

Macrophage migration inhibitory factor is critical for dengue NS1-induced endothelial glycocalyx degradation and hyperpermeability

Chen, H. R., Chao, C. H., Liu, C-C., Ho, T-S., Tsai, H. P., Perng, G-C., Lin, Y-S., Wang, J-R. & Yeh, T-M., 2018 Apr 1, In : PLoS pathogens. 14, 4, e1007033.

Research output: Contribution to journalArticle

Macrophage Migration-Inhibitory Factors
Glycocalyx
Dengue
Metalloproteases
Proteins
3 Citations (Scopus)

Minocycline suppresses dengue virus replication by down-regulation of macrophage migration inhibitory factor-induced autophagy

Lai, Y. C., Chuang, Y. C., Chang, C-P., Lin, Y-S., Perng, G-C., Wu, H. C., Hsieh, S. L. & Yeh, T-M., 2018 Jul 1, In : Antiviral Research. 155, p. 28-38 11 p.

Research output: Contribution to journalArticle

Macrophage Migration-Inhibitory Factors
Dengue Virus
Minocycline
Autophagy
Virus Replication

合成多肽、包含該合成多肽之疫苗組合物及其用途

Translated title of the contribution: SYNTHETIC POLYPEPTIDE, VACCINE COMPOSITION COMPRISING THE SAME, AND USES THEREOFYeh, T-M. & LAI, YEN-CHUNG., 2018 Aug 16, Patent No. (申請號)106136365, 2017 Oct 23

Research output: Patent

評估個體之登革熱病毒感染嚴重程度的方法

Translated title of the contribution: METHOD FOR ASSESSING THE SEVERITY OF DENGUE VIRUS INFECTION IN A SUBJECTHO, TZONG. SHIANN., CHUANG, YUNG. CHUN., HSU, PO. CHIH., CHENG, YU. WEI., LIU, CHING. CHUANG. & Yeh, T-M., 2018 May 21, Patent No. I624668, 2017 May 12, Priority date 2037 May 11

Research output: Patent

2017
7 Citations (Scopus)

Antibodies Against Modified NS1 Wing Domain Peptide Protect Against Dengue Virus Infection

Lai, Y. C., Chuang, Y. C., Liu, C-C., Ho, T-S., Lin, Y-S., Anderson, R. & Yeh, T-M., 2017 Dec 1, In : Scientific reports. 7, 1, 6975.

Research output: Contribution to journalArticle

Dengue Virus
Virus Diseases
Antibodies
Proteins
Dengue
4 Citations (Scopus)

Honeysuckle aqueous extract and induced let-7a suppress dengue virus type 2 replication and pathogenesis

Lee, Y. R., Yeh, S. F., Ruan, X. M., Zhang, H., Hsu, S. D., Huang, H. D., Hsieh, C. C., Lin, Y-S., Yeh, T-M., Liu, H-S. & Gan, D. D., 2017 Feb 23, In : Journal of Ethnopharmacology. 198, p. 109-121 13 p.

Research output: Contribution to journalArticle

Lonicera
Dengue Virus
Virus Replication
MicroRNAs
High-Throughput Nucleotide Sequencing
8 Citations (Scopus)

Therapeutic effects of monoclonal antibody against dengue virus NS1 in a STAT1 knockout mouse model of dengue infection

Wan, S. W., Chen, P. W., Chen, C. Y., Lai, Y. C., Chu, Y. T., Hung, C. Y., Lee, H., Wu, H. F., Chuang, Y. C., Lin, J., Chang, C-P., Wang, S-Y., Liu, C-C., Ho, T-S., Lin, C. F., Lee, C. K., Wu-Hsieh, B. A., Anderson, R., Yeh, T-M. & Lin, Y-S., 2017 Oct 15, In : Journal of Immunology. 199, 8, p. 2834-2844 11 p.

Research output: Contribution to journalArticle

Dengue Virus
Dengue
Therapeutic Uses
Knockout Mice
Monoclonal Antibodies
2016
7 Citations (Scopus)

Anti-dengue virus nonstructural protein 1 antibodies contribute to platelet phagocytosis by macrophages

Wan, S. W., Yang, Y. W., Chu, Y. T., Lin, C. F., Chang, C-P., Yeh, T-M., Anderson, R. & Lin, Y-S., 2016 Jan 1, In : Thrombosis and Haemostasis. 115, 3, p. 646-656 11 p.

Research output: Contribution to journalArticle

Dengue Virus
Phagocytosis
Blood Platelets
Macrophages
Antibodies
15 Citations (Scopus)

Dengue virus nonstructural protein 1-induced antibodies cross-react with human plasminogen and enhance its activation

Chuang, Y. C., Lin, J., Lin, Y-S., Wang, S-Y. & Yeh, T-M., 2016 Feb 1, In : Journal of Immunology. 196, 3, p. 1218-1226 9 p.

Research output: Contribution to journalArticle

Severe Dengue
Dengue Virus
Plasminogen
Antibodies
Proteins
28 Citations (Scopus)
Macrophage Migration-Inhibitory Factors
Dengue Virus
Severe Dengue
Autophagy
Blood Vessels

SYNTHETIC POLYPEPTIDE, VACCINE COMPOSITION COMPRISING THE SAME, AND USES THEREOF

Yeh, T-M. & 賴彥仲, 2016 Oct 21, Patent No. (美國臨時專利)62411493

Research output: Patent

2015
6 Citations (Scopus)

Correlation between serum levels of anti-endothelial cell autoantigen and anti-dengue virus nonstructural protein 1 antibodies in dengue patients

Cheng, H. J., Luo, Y. H., Wan, S. W., Lin, C. F., Wang, S-T., Hung, N. T., Liu, C-C., Ho, T-S., Liu, H-S., Yeh, T-M. & Lin, Y-S., 2015 May 1, In : American Journal of Tropical Medicine and Hygiene. 92, 5, p. 989-995 7 p.

Research output: Contribution to journalArticle

Dengue Virus
Dengue
Autoantigens
Protein Disulfide-Isomerases
Immunoglobulin M
5 Citations (Scopus)
Macrophage Migration-Inhibitory Factors
Autophagy
Concanavalin A
Hepatocellular Carcinoma
Cell Death
21 Citations (Scopus)

Macrophage migration inhibitory factor induces vascular leakage via autophagy

Chen, H. R., Chuang, Y. C., Chao, C. H. & Yeh, T-M., 2015 Feb 15, In : Biology Open. 4, 2, p. 244-252 9 p.

Research output: Contribution to journalArticle

Macrophage Migration-Inhibitory Factors
autophagy
Autophagy
blood vessels
Blood Vessels
14 Citations (Scopus)

Pathogenic roles of macrophage migration inhibitory factor during dengue virus infection

Chuang, Y. C., Chen, H. R. & Yeh, T-M., 2015 Jan 1, In : Mediators of Inflammation. 2015, 547094.

Research output: Contribution to journalReview article

Macrophage Migration-Inhibitory Factors
Severe Dengue
Dengue Virus
Virus Diseases
Viral Hemorrhagic Fevers

抗登革熱病毒非結構性蛋白1之單株抗體及其用途

Translated title of the contribution: ANTI-DENGUE VIRUS NONSTRUCTURAL PROTEIN 1 MONOCLONAL ANTIBODY AND USE THEREOFLin, Y-S. & Yeh, T-M., 2015 Dec 11, Patent No. I511977, 2014 Feb 27, Priority date 2034 Feb 26

Research output: Patent

2014

Lessons learned from dengue: Focus on Taiwan

Ho, T-S., Lin, C. F., Liu, C-C., Yeh, T-M., Anderson, R. & Lin, Y-S., 2014 Feb 1, Clinical Insights: Dengue: Transmission, Diagnosis & Surveillance. Future Medicine Ltd., p. 49-64 16 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Dengue Vaccines
Dengue
Taiwan
Epidemiology
Viruses
13 Citations (Scopus)

Macrophage migration inhibitory factor triggers chemotaxis of CD74+CXCR2+NKT cells in chemically induced IFN-γ-Mediated skin inflammation

Hsieh, C. Y., Chen, C. L., Lin, Y-S., Yeh, T-M., Tsai, T. T., Hong, M-Y. & Lin, C. F., 2014 Oct 1, In : Journal of Immunology. 193, 7, p. 3693-3703 11 p.

Research output: Contribution to journalArticle

Macrophage Migration-Inhibitory Factors
Natural Killer T-Cells
Chemotaxis
Inflammation
Skin
14 Citations (Scopus)
molecular mimicry
Molecular Mimicry
fibrinolysis
Dengue virus
Dengue Virus
23 Citations (Scopus)

Protection against dengue virus infection in mice by administration of antibodies against modified nonstructural protein 1

Wan, S. W., Lu, Y. T., Huang, C. H., Lin, C. F., Anderson, R., Liu, H-S., Yeh, T-M., Yen, Y. T., Wu-Hsieh, B. A. & Lin, Y-S., 2014 Mar 21, In : PloS one. 9, 3, e92495.

Research output: Contribution to journalArticle

Dengue virus
Dengue Virus
Virus Diseases
Viruses
antibodies
3 Citations (Scopus)

Ripple structure-generated hybrid electrokinetics for on-chip mixing and separating of functionalized beads

Cheng, I. F., Chiang, S. C., Chung, C. C., Yeh, T-M. & Chang, H-C., 2014 Dec 30, In : Biomicrofluidics. 8, 6, 066501.

Research output: Contribution to journalArticle

Electroosmosis
Convection
Microfluidics
electrokinetics
ripples

活化纖維蛋白溶酶原之抗體、其用途以及含有其之製劑

Translated title of the contribution: PLASMINOGEN-ACTIVATING ANTIBODY, USE THEREOF AND AGENT INCLUDING THE SAMEYeh, T-M. & CHUANG, YUNG. CHUN., 2014 Feb 21, Patent No. I427085, 2011 Dec 28, Priority date 2031 Dec 27

Research output: Patent

黃病毒科病毒感染之檢測方法

Translated title of the contribution: METHOD FOR DETECTING FLAVIVIRIDAE VIRUS INFECTIONYeh, T-M., CHUANG, YUNG. CHUN. & LIN, SHI. WEI., 2014 Mar 1, Patent No. I428598, 2011 Nov 23, Priority date 2031 Nov 22

Research output: Patent

2013
17 Citations (Scopus)

Absence of CXCL10 aggravates herpes stromal keratitis with reduced primary neutrophil influx in mice

Shen, F. H., Wang, S-W., Yeh, T-M., Tung, Y-Y., Hsu, S-M. & Chen, S., 2013 Jul 30, In : Journal of Virology. 87, 15, p. 8502-8510 9 p.

Research output: Contribution to journalArticle

Herpetic Keratitis
keratitis
Keratitis
neutrophils
cornea
12 Citations (Scopus)

Antibodies against thrombin in dengue patients contain both anti-thrombotic and pro-fibrinolytic activities

Chuang, Y. C., Lin, Y-S., Liu, H-S., Wang, J-R. & Yeh, T-M., 2013 Aug 2, In : Thrombosis and Haemostasis. 110, 2, p. 358-365 8 p.

Research output: Contribution to journalArticle

Dengue
Thrombin
Antibodies
Severe Dengue
Dengue Virus
21 Citations (Scopus)

Anti-dengue virus nonstructural protein 1 antibodies cause NO-mediated endothelial cell apoptosis via ceramide-regulated glycogen synthase kinase-3β and NF-κB activation

Chen, C. L., Lin, C. F., Wan, S. W., Wei, L. S., Chen, M. C., Yeh, T-M., Liu, H-S., Anderson, R. & Lin, Y-S., 2013 Aug 15, In : Journal of Immunology. 191, 4, p. 1744-1752 9 p.

Research output: Contribution to journalArticle

Glycogen Synthase Kinase 3
Dengue Virus
Ceramides
Endothelial Cells
Apoptosis
41 Citations (Scopus)

Autoimmunity in dengue pathogenesis

Wan, S. W., Lin, C. F., Yeh, T-M., Liu, C-C., Liu, H-S., Wang, S-Y., Ling, P., Anderson, R., Lei, H. Y. & Lin, Y-S., 2013 Jan 1, In : Journal of the Formosan Medical Association. 112, 1, p. 3-11 9 p.

Research output: Contribution to journalReview article

Dengue Virus
Dengue
Severe Dengue
Autoimmunity
Virus Diseases
48 Citations (Scopus)

Current progress in dengue vaccines

Wan, S. W., Lin, C. F., Wang, S-Y., Chen, Y-H., Yeh, T-M., Liu, H-S., Anderson, R. & Lin, Y-S., 2013 Jun 17, In : Journal of biomedical science. 20, 1, 37.

Research output: Contribution to journalReview article

Dengue Vaccines
Viruses
Severe Dengue
Attenuated Vaccines
Dengue
19 Citations (Scopus)

Dengue Virus Enhances Thrombomodulin and ICAM-1 Expression through the Macrophage Migration Inhibitory Factor Induction of the MAPK and PI3K Signaling Pathways

Yeh, T-M., Liu, S. H., Lin, K. C., Kuo, C., Kuo, S. Y., Huang, T. Y., Yen, Y. R., Wen, R. K., Chen, L. C. & Fu, T. F., 2013 Jan 28, In : PloS one. 8, 1, e55018.

Research output: Contribution to journalArticle

Macrophage Migration-Inhibitory Factors
Thrombomodulin
Dengue virus
Dengue Virus
phosphatidylinositol 3-kinase
45 Citations (Scopus)

Dengue virus infection induces autophagy: An in vivo study

Lee, Y. R., Hu, H. Y., Kuo, S. H., Lei, H. Y., Lin, Y-S., Yeh, T-M., Liu, C-C. & Liu, H-S., 2013 Sep 11, In : Journal of biomedical science. 20, 1, 65.

Research output: Contribution to journalArticle

Dengue Virus
Autophagy
Virus Diseases
Viruses
Virus Replication
17 Citations (Scopus)

Factors contributing to the disturbance of coagulation and fibrinolysis in dengue virus infection

Chuang, Y. C., Lin, Y-S., Liu, C-C., Liu, H-S., Liao, S. H., Shi, M. D., Lei, H. Y. & Yeh, T-M., 2013 Jan 1, In : Journal of the Formosan Medical Association. 112, 1, p. 12-17 6 p.

Research output: Contribution to journalReview article

Dengue Virus
Fibrinolysis
Virus Diseases
Hemorrhage
Severe Dengue
21 Citations (Scopus)

Propolis inhibits TGF-β1-induced epithelial-mesenchymal transition in human alveolar epithelial cells via PPARγ activation

Kao, H. F., Chang-Chien, P. W., Chang, W-T., Yeh, T-M. & Wang, J-Y., 2013 Mar 1, In : International Immunopharmacology. 15, 3, p. 565-574 10 p.

Research output: Contribution to journalArticle

Propolis
Alveolar Epithelial Cells
Epithelial-Mesenchymal Transition
PPAR gamma
Transforming Growth Factors
16 Citations (Scopus)

Re-evaluation of the pathogenic roles of nonstructural protein 1 and its antibodies during dengue virus infection

Chuang, Y. C., Wang, S-Y., Lin, Y-S., Chen, H. R. & Yeh, T-M., 2013 Jul 2, In : Journal of biomedical science. 20, 1, 42.

Research output: Contribution to journalReview article

Severe Dengue
Dengue Virus
Virus Diseases
Viruses
Antibodies
2012
45 Citations (Scopus)

Dengue virus nonstructural protein NS1 binds to prothrombin/thrombin and inhibits prothrombin activation

Lin, S. W., Chuang, Y. C., Lin, Y-S., Lei, H. Y., Liu, H-S. & Yeh, T-M., 2012 Mar 1, In : Journal of Infection. 64, 3, p. 325-334 10 p.

Research output: Contribution to journalArticle

Dengue Virus
Prothrombin
Thrombin
Dengue
Hemorrhage
41 Citations (Scopus)

Macrophage migration inhibitory factor induces autophagy via reactive oxygen species generation

Chuang, Y. C., Su, W. H., Lei, H. Y., Lin, Y-S., Liu, H-S., Chang, C-P. & Yeh, T-M., 2012 May 22, In : PloS one. 7, 5, e37613.

Research output: Contribution to journalArticle

Macrophage Migration-Inhibitory Factors
autophagy
Autophagy
reactive oxygen species
Reactive Oxygen Species
8 Citations (Scopus)

Macrophage migration inhibitory factor induces ICAM-1and thrombomobulin expression in vitro

Shyu, L. Y., Yeh, T-M., Chang, H. H., Lin, D. P. C., Teng, Y. H., Chen, L. C. & Lee, H. H., 2012 Jan 1, In : Thrombosis Research. 129, 1, p. 43-49 7 p.

Research output: Contribution to journalArticle

Macrophage Migration-Inhibitory Factors
Thrombomodulin
Intercellular Adhesion Molecule-1
Human Migration
Blood Coagulation Factors
2011
27 Citations (Scopus)

Dengue virus-induced autoantibodies bind to plasminogen and enhance its activation

Chuang, Y. C., Lei, H. Y., Lin, Y-S., Liu, H-S., Wu, H-L. & Yeh, T-M., 2011 Dec 15, In : Journal of Immunology. 187, 12, p. 6483-6490 8 p.

Research output: Contribution to journalArticle

Severe Dengue
Dengue Virus
Plasminogen
Autoantibodies
Fibrinolysin
46 Citations (Scopus)

Macrophage migration inhibitory factor induced by dengue virus infection increases vascular permeability

Chuang, Y. C., Lei, H. Y., Liu, H-S., Lin, Y-S., Fu, T-F. & Yeh, T-M., 2011 May 1, In : Cytokine. 54, 2, p. 222-231 10 p.

Research output: Contribution to journalArticle

Macrophage Migration-Inhibitory Factors
Dengue Virus
Capillary Permeability
Virus Diseases
Viruses
64 Citations (Scopus)

Molecular mimicry between virus and host and its implications for dengue disease pathogenesis

Lin, Y-S., Yeh, T-M., Lin, C. F., Wan, S. W., Chuang, Y. C., Hsu, T. K., Liu, H-S., Liu, C-C., Anderson, R. & Lei, H. Y., 2011 May 1, In : Experimental Biology and Medicine. 236, 5, p. 515-523 9 p.

Research output: Contribution to journalReview article

Molecular Mimicry
Dengue
Dengue Virus
Viruses
Proteins
3 Citations (Scopus)

Zebrafish Sp1-like protein is structurally and functionally comparable to human Sp1

Lin, C. J., Hsiao, T. H., Chung, Y. S., Chang, W. N., Yeh, T-M., Chen, B. H. & Fu, T-F., 2011 Mar 1, In : Protein Expression and Purification. 76, 1, p. 36-43 8 p.

Research output: Contribution to journalArticle

Zebrafish
Zebrafish Proteins
Recombinant Proteins
Proteins
Sp1 Transcription Factor
2010
10 Citations (Scopus)

Annexin A2 on lung epithelial cell surface is recognized by severe acute respiratory syndrome-associated coronavirus spike domain 2 antibodies

Fang, Y. T., Lin, C. F., Liao, P-C., Kuo, Y-M., Wang, S-Y., Yeh, T-M., Shieh, C-C., Su, I. J., Lei, H. Y. & Lin, Y-S., 2010 Feb 1, In : Molecular Immunology. 47, 5, p. 1000-1009 10 p.

Research output: Contribution to journalArticle

Annexin A2
Severe Acute Respiratory Syndrome
Coronavirus
Epithelial Cells
Lung
50 Citations (Scopus)

Characteristic of dengue disease in Taiwan: 2002-2007

Lin, C. C., Huang, Y. H., Shu, P. Y., Wu, H. S., Lin, Y-S., Yeh, T-M., Liu, H-S., Liu, C-C. & Lei, H. Y., 2010 Apr 1, In : American Journal of Tropical Medicine and Hygiene. 82, 4, p. 731-739 9 p.

Research output: Contribution to journalArticle

Dengue
Taiwan
Dengue Virus
Infection
Severe Dengue
8 Citations (Scopus)

The dengue virus envelope protein induced PAI-1 gene expression via MEK/ERK pathways

Shyu, H. W., Lin, Y. Y., Chen, L. C., Wang, Y. F., Yeh, T-M., Su, S. J., Cheng, W. C., Chen, C. Y., Lin, K. H. & Chou, M. C., 2010 Dec 1, In : Thrombosis and Haemostasis. 104, 6, p. 1219-1227 9 p.

Research output: Contribution to journalArticle

Viral Envelope Proteins
Dengue Virus
Plasminogen Activator Inhibitor 1
Mitogen-Activated Protein Kinase Kinases
Extracellular Signal-Regulated MAP Kinases
11 Citations (Scopus)

The envelope glycoprotein domain III of dengue virus type 2 induced the expression of anticoagulant molecules in endothelial cells

Chen, L. C., Yeh, T-M., Lin, Y. Y., Wang, Y. F., Su, S. J., Chen, C. Y., Lin, K. H., Chou, M. C. & Shyu, H. W., 2010 Sep 1, In : Molecular and Cellular Biochemistry. 342, 1-2, p. 215-221 7 p.

Research output: Contribution to journalArticle

Dengue Virus
Endothelial cells
Severe Dengue
Viruses
Anticoagulants